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JOURNAL ARTICLE
Sarah Lahire, Caroline Fichel, Océane Rubaszewski, Cédric Lereverend, Sandra Audonnet, Vincent Visneux, Jeanne-Marie Perotin, Gaëtan Deslée, Sébastien Le Jan, Stéphane Potteaux, Richard Le Naour, Arnaud Pommier
Chronic obstructive pulmonary disease (COPD) is a condition characterized by chronic airway inflammation and obstruction, primarily caused by tobacco smoking. Although the involvement of immune cells in COPD pathogenesis is well established, the contribution of innate lymphoid cells (ILC) remains poorly understood. ILC are a type of innate immune cells that participate in tissue remodeling processes, but their specific role in COPD has not been fully elucidated. During COPD, the breakdown of pulmonary elastin generates elastin peptides that elicit biological activities on immune cells...
May 7, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
#2
JOURNAL ARTICLE
Mary Katherine Donovan, Abdel A Abdel-Rahman
BACKGROUND: Current research on ethanol-induced cardiovascular anomalies has focused on left ventricular (LV) function and blood pressure. To extend this area of research, we sought to determine whether ethanol-induced alterations in the structure and function of the right cardiac ventricle (RV) and pulmonary artery (PA) lead to pulmonary arterial hypertension (PAH). METHODS: Two groups of male Sprague-Dawley rats received a balanced liquid diet containing 5% ethanol (w/v) or a pair-fed isocaloric liquid diet for 8 weeks...
May 6, 2024: Alcohol Clin Exp Res (Hoboken)
#3
JOURNAL ARTICLE
Marie Lundberg, Helena Voutilainen, Annina Lyly, Jussi Karjalainen, Heini Huhtala, Tanya M Laidlaw, Stella E Lee, Mikko Nuutinen, Sanna Toppila-Salmi
BACKGROUND: The adoption of avoidance diets by adult-onset asthmatics has not previously been studied. We hypothesized that avoidance diets would associate with adult-onset asthma, allergy, and aspirin-exacerbated respiratory disease (AERD). METHODS: A total of 1247 subjects with adult-onset asthma (age range: 31-91) from the Finnish national registry, and age- and sex-matched controls ( n = 1970) participated in a questionnaire study in 1997. We estimated the association between asthma/allergy/AERD and avoidance diets, adjusting for potential confounding factors and validated the results in two retrospective cohorts of 5080 rhinitis/rhinosinusitis patients and 167 AERD patients from 2019 to 2020...
2024: European Clinical Respiratory Journal
#4
JOURNAL ARTICLE
Shen Zhang, Mikaël Simard, Andréanne Lapointe, Édith Filion, Marie-Pierre Campeau, Thi Trinh Thuc Vu, David Roberge, Jean-François Carrier, Danis Blais, Stéphane Bedwani, Houda Bahig
PURPOSE: There is interest in using dual-energy computed tomography (DECT) to evaluate organ function before and after radiotherapy. The purpose of this study (trial identifier: XXXX) is to assess longitudinal changes in lung perfusion using iodine maps derived from DECT in lung cancer patients treated with conventional or stereotactic radiotherapy (RT). METHODS: For 48 prospectively enrolled lung cancer patients, a contrast-enhanced DECT using a dual-source CT simulator was acquired pre-treatment and at 6 and 12 months post-treatment...
May 3, 2024: International Journal of Radiation Oncology, Biology, Physics
#5
JOURNAL ARTICLE
Benjamin J Lang, Kristina M Holton, Martin E Guerrero-Gimenez, Yuka Okusha, Patrick T Magahis, Amy Shi, Mary Neguse, Shreya Venkatesh, Anh M Nhu, Jason E Gestwicki, Stuart K Calderwood
This study identified tumorigenic processes most dependent on murine HSP72 in the MMTV-PyMT mammary tumor model, which give rise to spontaneous mammary tumors that exhibit HSP72-dependent metastasis to the lung. RNA-seq expression profiling of Hspa1a/Hspa1b (Hsp72) WT and Hsp72-/- primary mammary tumors discovered significantly lower expression of genes encoding components of the extracellular matrix (ECM) in Hsp72 knockout mammary tumors compared to WT controls. In vitro studies found that genetic or chemical inhibition of HSP72 activity in cultured collagen-expressing human or murine cells also reduces mRNA and protein levels of COL1A1 and several other ECM-encoding genes...
May 2, 2024: Cell Stress & Chaperones
#6
JOURNAL ARTICLE
Maria J Knol, Raymond A Poot, Tavia E Evans, Claudia L Satizabal, Aniket Mishra, Muralidharan Sargurupremraj, Sandra van der Auwera, Marie-Gabrielle Duperron, Xueqiu Jian, Isabel C Hostettler, Dianne H K van Dam-Nolen, Sander Lamballais, Mikolaj A Pawlak, Cora E Lewis, Amaia Carrion-Castillo, Theo G M van Erp, Céline S Reinbold, Jean Shin, Markus Scholz, Asta K Håberg, Anders Kämpe, Gloria H Y Li, Reut Avinun, Joshua R Atkins, Fang-Chi Hsu, Alyssa R Amod, Max Lam, Ami Tsuchida, Mariël W A Teunissen, Nil Aygün, Yash Patel, Dan Liang, Alexa S Beiser, Frauke Beyer, Joshua C Bis, Daniel Bos, R Nick Bryan, Robin Bülow, Svenja Caspers, Gwenaëlle Catheline, Charlotte A M Cecil, Shareefa Dalvie, Jean-François Dartigues, Charles DeCarli, Maria Enlund-Cerullo, Judith M Ford, Barbara Franke, Barry I Freedman, Nele Friedrich, Melissa J Green, Simon Haworth, Catherine Helmer, Per Hoffmann, Georg Homuth, M Kamran Ikram, Clifford R Jack, Neda Jahanshad, Christiane Jockwitz, Yoichiro Kamatani, Annchen R Knodt, Shuo Li, Keane Lim, W T Longstreth, Fabio Macciardi, Outi Mäkitie, Bernard Mazoyer, Sarah E Medland, Susumu Miyamoto, Susanne Moebus, Thomas H Mosley, Ryan Muetzel, Thomas W Mühleisen, Manabu Nagata, Soichiro Nakahara, Nicholette D Palmer, Zdenka Pausova, Adrian Preda, Yann Quidé, William R Reay, Gennady V Roshchupkin, Reinhold Schmidt, Pamela J Schreiner, Kazuya Setoh, Chin Yang Shapland, Stephen Sidney, Beate St Pourcain, Jason L Stein, Yasuharu Tabara, Alexander Teumer, Anne Uhlmann, Aad van der Lugt, Meike W Vernooij, David J Werring, B Gwen Windham, A Veronica Witte, Katharina Wittfeld, Qiong Yang, Kazumichi Yoshida, Han G Brunner, Quentin Le Grand, Kang Sim, Dan J Stein, Donald W Bowden, Murray J Cairns, Ahmad R Hariri, Ching-Lung Cheung, Sture Andersson, Arno Villringer, Tomas Paus, Sven Cichon, Vince D Calhoun, Fabrice Crivello, Lenore J Launer, Tonya White, Peter J Koudstaal, Henry Houlden, Myriam Fornage, Fumihiko Matsuda, Hans J Grabe, M Arfan Ikram, Stéphanie Debette, Paul M Thompson, Sudha Seshadri, Hieab H H Adams
The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants...
May 3, 2024: Cell reports medicine
#7
JOURNAL ARTICLE
Niccolette Schaunaman, Diana Cervantes, Taylor Nichols, Mari Numata, Julie G Ledford, Monica Kraft, Hong Wei Chu
BACKGROUND: Influenza A virus (IAV) infection is a significant risk factor for respiratory diseases, but the host defense mechanisms against IAV remain to be defined. Immune regulators such as surfactant protein A (SP-A) and Toll-interacting protein (Tollip) have been shown to be involved in IAV infection, but whether SP-A and Tollip cooperate in more effective host defense against IAV infection has not been investigated. METHODS: Wild-type (WT), Tollip knockout (KO), SP-A KO, and Tollip/SP-A double KO (dKO) mice were infected with IAV for four days...
May 3, 2024: Respiratory Research
#8
REVIEW
Alexander Lynge Reese-Petersen, Signe Holm Nielsen, Jannie Marie Bülow Sand, Jörn M Schattenberg, Elisabetta Bugianesi, Morten A Karsdal
Fibrosis is a common feature of more than 50 different diseases and the cause of more than 35% of deaths worldwide, of which liver, kidney, skin, heart and, recently, lungs are receiving the most attention. Tissue changes, resulting in loss of organ function, are both a cause and consequence of disease and outcome. Fibrosis is caused by an excess deposition of extracellular matrix proteins, which over time results in impaired organ function and organ failure, and the pathways leading to increased fibroblast activation are many...
May 3, 2024: Diabetes, Obesity & Metabolism
#9
JOURNAL ARTICLE
Yu Chen, Lung-Yi Mak, Mary H Y Tang, Jingyi Yang, Chun Bong Chow, Ai-Ming Tan, Tao Lyu, Juan Wu, Qingjuan Huang, Hai-Bo Huang, Ka-Shing Cheung, Man-Fung Yuen, Wai-Kay Seto
BACKGROUND & AIMS: Peripartum prophylaxis (PP) with tenofovir disoproxil fumarate (TDF) is the standard of care to prevent mother-to-child transmission of chronic hepatitis B (CHB) infection in mothers who are highly viremic. We investigated the maternal and infant outcomes in a large Chinese cohort of TDF-treated CHB pregnant participants. METHODS: In this prospective study, treatment-naive mothers with CHB and highly viremic (HBV DNA ≥200,000 IU/ml) but without cirrhosis were treated with TDF at 24-28 weeks of pregnancy...
May 2024: JHEP reports: innovation in hepatology
#10
REVIEW
Malik A Althobiani, Anne-Marie Russell, Joseph Jacob, Yatharth Ranjan, Amos A Folarin, John R Hurst, Joanna C Porter
Interstitial lung diseases (ILDs) refer to a heterogeneous and complex group of conditions characterized by inflammation, fibrosis, or both, in the interstitium of the lungs. This results in impaired gas exchange, leading to a worsening of respiratory symptoms and a decline in lung function. While the etiology of some ILDs is unclear, most cases can be traced back to factors such as genetic predispositions, environmental exposures (including allergens, toxins, and air pollution), underlying autoimmune diseases, or the use of certain medications...
2024: Frontiers in Medicine
#11
Hiroaki Matsuura, Hisao Higo, Tadahiro Kuribayashi, Akihiko Tamaoki, Takamasa Nakasuka, Mari Uno, Go Makimoto, Kiichiro Ninomiya, Masanori Fujii, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Nobuaki Miyahara, Masahiro Tabata, Yoshinobu Maeda, Katsuyuki Kiura, Kadoaki Ohashi
The concurrent incidence of lung cancer and tuberculosis is expected to escalate due to the projected growth in the older population. Combination therapy with osimertinib and antituberculosis drugs has not been well-established. We report a case of successful treatment involving the concomitant administration of osimertinib and antituberculosis drugs in an older patient, an 89-year-old female, diagnosed with epidermal growth factor receptor (EGFR)-mutant lung cancer and pulmonary tuberculosis. Accumulating evidence is warranted to develop an optimal treatment strategy for patients with lung cancer and tuberculosis...
May 2, 2024: Thoracic Cancer
#12
JOURNAL ARTICLE
Breanne Golemiec, Madison Robertson, Vincent Poon, Mary Foley, Christopher M Parker, Craig McGann, Nicole O'Callaghan, Geneviève C Digby
PURPOSE: In Southeastern Ontario, increased patient distance from the regional lung cancer diagnostic assessment program (LDAP) is associated with a lower likelihood of patient care via LDAP while receiving care via LDAP is associated with improved survival. We implemented an LDAP outreach clinic to provide specialist assessment for patients with suspected lung cancer at a regional community hospital and assessed the impact on timeliness and accessibility of care. MATERIALS AND METHODS: The Kingston Health Sciences Centre LDAP team engaged with community hospital partners to develop and launch the LDAP outreach clinic...
May 2, 2024: JCO oncology practice
#13
Alicia Mastrocco, Jennifer Prittie, Ann Marie Zollo
OBJECTIVE: To describe the successful conservative management of chemical pneumonitis and presumed acute respiratory distress syndrome in a cat secondary to inadvertent pulmonary polyethylene glycol-electrolyte solution (PEG-ELS) instillation. CASE SUMMARY: PEG-ELS is commonly used in small animals for bowel cleansing and to treat constipation. There have been several instances of aspiration or accidental instillation of this solution into the lungs of both people and dogs...
May 2, 2024: Journal of Veterinary Emergency and Critical Care
#14
REVIEW
Mary Beth Beasley
Interstitial lung abnormalities (ILA) is a radiographic term, which has recently undergone clarification of definition with creation of 3 subtypes. ILA is defined as incidental identification of computed tomography abnormalities in a patient who is not suspected of having an interstitial lung disease (ILD). A subset of ILA may progress to clinically significant ILD and is associated with morbidities not related to progression such as an increased incidence of sepsis-related acute respiratory distress syndrome (ARDS)...
June 2024: Surgical Pathology Clinics
#15
JOURNAL ARTICLE
Kathleen L Grady, Michael A Kallen, David Cella, Larry A Allen, JoAnn Lindenfeld, Colleen K McIlvennan, David G Beiser, Mary Norine Walsh, Quin E Denfeld, Christopher S Lee, Bernice Ruo, Catherine Murks, Josef Stehlik, James K Kirklin, Jeffrey Teuteberg, Eric Adler, Michael Kiernan, Jonathan Rich, Katy Bedjeti, Elizabeth A Hahn
BACKGROUND: Patient-reported outcome (PRO) measures of distinct concepts are often put together into patient profile assessments. When brief, profile assessments can decrease respondent burden and increase measure completion rates. In this report, we describe creation of five self-reported 4-item short forms and the MCS A-QOL 20-item profile to assess PROs specific to adjustment and health-related quality of life (HRQOL) among patients who undergo left ventricular assist device (LVAD) implantation...
April 29, 2024: Journal of Heart and Lung Transplantation
#16
RANDOMIZED CONTROLLED TRIAL
Matthew R Lammi, Monica Mukherjee, Lesley Ann Saketkoo, Kyle Carey, Laura Hummers, Steven Hsu, Amita Krishnan, Marie Sandi, Ami A Shah, Stefan L Zimmerman, Paul M Hassoun, Steven C Mathai
BACKGROUND: Pulmonary hypertension (PH) is a leading cause of death in patients with systemic sclerosis (SSc). An important component of SSc patient management is early detection and treatment of PH. Recently the threshold for the diagnosis of PH has been lowered to a mean pulmonary artery pressure (mPAP) threshold of > 20 mmHg on right heart catheterization (RHC). However, it is unknown if PH-specific therapy is beneficial in SSc patients with mildly elevated pressure (SSc-MEP, mPAP 21-24 mmHg)...
April 30, 2024: BMC Pulmonary Medicine
#17
JOURNAL ARTICLE
Maggie Fong, Amy Liu, Bryan Lung, Ibrahim Alayche, Shahab Sayfi, Ryan Yuhi Kirenga, Marie Hélène Chomienne, Ammar Saad, Jean Grenier, Azaad Kassam, Rukhsana Ahmed, Kevin Pottie
BACKGROUND AND OBJECTIVES: Newcomers (immigrants, refugees, and international students) face many personal, gender, cultural, environmental and health system barriers when integrating into a new society. These struggles can affect their health and social care, reducing access to mental health care. This study explores the lived experiences of African and Middle Eastern newcomers to Ontario, Canada. An understanding of newcomer integration challenges, successes and social justice issues is needed to improve health equity and social services...
2024: PloS One
#18
JOURNAL ARTICLE
Donald McLean, Olivia Delfino, Marie Vozzo, Rachael Moorin
INTRODUCTION: While there are many papers on maternal and foetal radiation doses from computed tomography pulmonary angiography (CTPA) and ventilation/perfusion (V/Q) lung scanning examinations for diagnosing pulmonary embolism in pregnant patients, few have used clinical data to examine the patient lifetime attributable risk (LAR) of different cancer types. This paper aims to estimate the cancer risk from maternal radiation doses from CTPA and V/Q examinations and associated foetal doses...
April 30, 2024: Journal of Medical Imaging and Radiation Oncology
#19
JOURNAL ARTICLE
Mari Miki, Keisuke Miki, Eri Akiba, Hiroyuki Kagawa, Yohei Oshitani, Takanori Matsuki, Kazuyuki Tsujino, Seigo Kitada, Ryoji Maekura, Hiroshi Kida
BACKGROUND: Measurement of exhaled nitric oxide (FeNO) is a potentially useful diagnostic test for asthma. However, no study has explored the relationship between FeNO and respiratory symptoms of nontuberculous mycobacterial pulmonary disease (NTM-PD) complicated with asthma. The objective of this study was to assess the utility of measuring FeNO levels in patients with NTM-PD complicated by asthma. METHODS: In this single-center retrospective cohort study, 140 NTM-PD patients with FeNO measured were enrolled...
April 29, 2024: BMC Pulmonary Medicine
#20
JOURNAL ARTICLE
Zsuzsanna Bordan, Robert Batori, Stephen Haigh, Xueyi Li, Mary Louise Meadows, Zach L Brown, Madison A West, Kunzhe Dong, Weihong Han, Yunchao Su, Qian Ma, Yuqing Huo, Jiliang Zhou, Mahmoud Abdelbary, Jennifer Sullivan, Neal L Weintraub, David W Stepp, Feng Chen, Scott A Barman, David J R Fulton
BACKGROUND: Pulmonary arterial hypertension (PAH) is high blood pressure in the lungs that originates from structural changes in small resistance arteries. A defining feature of PAH is the inappropriate remodeling of pulmonary arteries (PA) leading to right ventricle failure and death. Although treatment of PAH has improved, the long-term prognosis for patients remains poor, and more effective targets are needed. METHODS: Gene expression was analyzed by microarray, RNA sequencing, quantitative polymerase chain reaction, Western blotting, and immunostaining of lung and isolated PA in multiple mouse and rat models of pulmonary hypertension (PH) and human PAH...
April 29, 2024: Circulation
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