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COMT Val158Met

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https://www.readbyqxmd.com/read/28635556/executive-control-in-schizophrenia-a-preliminary-study-on-the-moderating-role-of-comt-val158met-for-comorbid-alcohol-and-substance-use-disorders
#1
Giuseppe Carrà, Gabriella Nicolini, Cristina Crocamo, Annamaria Lax, Francesca Amidani, Francesco Bartoli, Filippo Castellano, Alessia Chiorazzi, Giulia Gamba, Costanza Papagno, Massimo Clerici
BACKGROUND: A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis. METHODS: To explore the potential moderating effect of these factors, a cross-sectional study was conducted, randomly recruiting subjects with DSM-IV diagnosis of schizophrenia. AUD/SUD was rigorously assessed, as well as COMT Val158Met polymorphism. Executive control functioning was measured using the Intra-Extra Dimensional Set Shift (IED)...
February 14, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28625321/catechol-o-methyltransferase-gene-polymorphism-val158met-and-development-of-pre-eclampsia
#2
Ali Taravati, Fatemeh Tohidi, Mehrnaz Moniri, Kasra Kamali
OBJECTIVES: Catechol-O-methyltransferase (COMT) is a key enzyme in degradation pathways of estrogens and catecholamines. The present meta-analysis was done to elucidate the association of COMT Val158Met polymorphism with pre-eclampsia among pregnant women. METHODS: A literature search was conducted in electronic databases including PubMed, Scopus, Elsevier, Springer and Google Scholar to find eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals were calculated under dominant, recessive, co-dominant, and allelic models...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28610409/impact-of-catechol-o-methyltransferase-val-158met-rs4680-polymorphism-on-breast-cancer-susceptibility-in-asian-population
#3
Vandana Rai, Upendra Yadav, Pradeep Kumar
Background: Catechol-O-methyltransferase (COMT) is an important estrogen-metabolizing enzyme. Numerous case-control studies have evaluated the role COMT Val 158Met (rs4680;472G->A) polymorphism in the risk of breast cancer and provided inconclusive results, hence present meta-analysis was designed to get a more reliable assessment in Asian population. Methods: A total of 26 articles were identified through a search of four electronic databases- PubMed, Google Scholar, Science Direct and Springer link, up to March, 2016...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28608575/association-between-comt-val158met-and-psychiatric-disorders-a-comprehensive-meta-analysis
#4
Steven Taylor
Catechol-O-methyltransferase (COMT) Val158Met is widely regarded as potentially important for understanding the genetic etiology of many different psychiatric disorders. The present study appears to be the first comprehensive meta-analysis of COMT genetic association studies to cover all psychiatric disorders for which there were available data, published in any language, and with an emphasis on investigating disorder subtypes (defined clinically or by demographic or other variables). Studies were included if they reported one or more datasets (i...
June 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28608189/effect-of-catechol-o-methyltransferase-val158met-polymorphism-on-resting-state-brain-default-mode-network-after-acupuncture-stimulation
#5
Xuejuan Yang, Jie Gong, Lingmin Jin, Lin Liu, Jinbo Sun, Wei Qin
The effects of acupuncture can be characterized by clear individual differences. Several revealing studies suggest an underlying role of inherited genetic factor in interindividual variability in response to acupuncture treatment. It remains unclear, however, if the modulation of acupuncture on resting brain function is influenced by genetic factors. Catechol-o-methyltransferase (COMT) Val158Met polymorphism has been shown to regulate the resting brain network, especially in the default mode network (DMN), which is a target area that responds to acupuncture stimulation...
June 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28562378/lack-of-association-between-comt-val158met-and-zdhhc8-rs175174-polymorphisms-and-susceptibility-to-schizophrenia-in-a-brazilian-population
#6
Leopoldo S Moraes, Augusto C C Santos, Hygor Ferreira-Fernandes, France K N Yoshioka, Silmar S Teixeira, Adriana C Guimarães, Carlos A M da Rocha, Juan A Rey, Giovanny R Pinto, Rommel R Burbano
No abstract text is available yet for this article.
May 30, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28556887/comt-val158met-and-mthfr-c677t-moderate-risk-of-schizophrenia-in-response-to-childhood-adversity
#7
J-C Debost, M Debost, J Grove, O Mors, D M Hougaard, A D Børglum, P B Mortensen, L Petersen
OBJECTIVE: Mesolimbic dopamine sensitization has been hypothesized to be a mediating factor of childhood adversity (CA) on schizophrenia risk. Activity of catechol-O-methyltransferase (COMT) Val158Met increases mesolimbic dopamine signaling and may be further regulated by methylenetetrahydrofolate reductase (MTHFR) C677T. This study investigates the three-way interaction between CA, COMT, and MTHFR. METHODS: We conducted a nested case-control study on individuals born after 1981, linking population-based registers to study the three-way interaction...
May 29, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28544426/the-catechol-o-methyltransferase-comt-val158met-genotype-modulates-working-memory-related-dorsolateral-prefrontal-response-and-performance-in-bipolar-disorder
#8
K W Miskowiak, H L Kjaerstad, M M Støttrup, A M Svendsen, K M Demant, L K Hoeffding, T M Werge, K E Burdick, K Domschke, A F Carvalho, E Vieta, M Vinberg, L V Kessing, H R Siebner, J Macoveanu
OBJECTIVES: Cognitive dysfunction affects a substantial proportion of patients with bipolar disorder (BD), and genetic-imaging paradigms may aid in the elucidation of mechanisms implicated in this symptomatic domain. The Val allele of the functional Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene is associated with reduced prefrontal cortex dopamine and exaggerated working memory-related prefrontal activity. This functional magnetic resonance imaging (fMRI) study investigated for the first time whether the COMT Val158Met genotype modulates prefrontal activity during spatial working memory in BD...
May 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28523234/the-effect-of-comt-val158met-and-drd2-c957t-polymorphisms-on-executive-function-and-the-impact-of-early-life-stress
#9
Kristel Klaus, Kevin Butler, Simon J Durrant, Manir Ali, Chris F Inglehearn, Timothy L Hodgson, Humberto Gutierrez, Kyla Pennington
INTRODUCTION: Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. However, increasing evidence suggests environmental factors such as early life stress may interact with genetic variants in affecting these cognitive outcomes. This study investigated the effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress in healthy adults...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28522796/effects-of-%C3%AE-adrenoceptor-and-catechol-o-methyl-transferase-comt-polymorphism-on-postoperative-outcome-in-cardiac-surgery-patients
#10
Stefan Dhein, Pascal M Dohmen, Matthias Sauer, Julia Tews, Johannes Weickmann, Anne-Kathrin Funkat, Martin Misfeld, Michael A Borger, Friedrich W Mohr
BACKGROUND There is a long-standing debate about the role of beta-adrenoceptor polymorphisms in the cardiovascular system. We wanted to elucidate whether β1-adrenoceptor-polymorphisms affects the postoperative catecholamine consumption and the length of intermediate care unit stay in patients undergoing cardiac surgery, and whether this might be enhanced or attenuated by catechol-O-methyl-transferase (COMT) polymorphism. MATERIAL AND METHODS We included 116 patients (63±1.2 years; 34% females; 81±1 kg) undergoing cardiac surgery...
May 19, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28473194/association-of-catechol-o-methyltransferase-polymorphism-val158met-and-mammographic-density-a-meta-analysis
#11
Roope A Kallionpää, Elina Uusitalo, Juha Peltonen
OBJECTIVES: The Val158Met polymorphism in catechol-O-methyltransferase (COMT) enzyme reduces the methylation of catechol estrogens, which may affect mammographic density. High mammographic density is a known risk factor of breast cancer. Our aim was to perform meta-analysis of the effect of COMT Val158Met polymorphism on mammographic density. METHODS: Original studies reporting data on mammographic density, stratified by the presence of COMT Val158Met polymorphism, were identified and combined using genetic models Met/Val vs...
August 15, 2017: Gene
https://www.readbyqxmd.com/read/28452825/joint-impact-of-early-life-adversity-and-comt-val158met-rs4680-genotypes-on-the-adult-cortisol-response-to-psychological-stress
#12
William R Lovallo, Mary-Anne Enoch, Kristen H Sorocco, Andrea S Vincent, Ashley Acheson, Andrew J Cohoon, Colin A Hodgkinson, David Goldman
OBJECTIVE: Exposure to stress during critical periods of development can diminish stress reactivity by the hypothalamic-pituitary-adrenocortical axis. Genetic characteristics may further modify this effect of early adversity, leading to a gene-by-environment (G x E) interaction on stress reactivity in adulthood. Val-allele carriers of a common polymorphism of the COMT gene (Val158Met, rs4680) have rapid removal of catecholamines in the prefrontal cortex, limbic system, and reward centers...
April 27, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28416295/depressive-symptoms-in-schizophrenia-and-dopamine-and-serotonin-gene-polymorphisms
#13
Vjekoslav Peitl, Mario Štefanović, Dalibor Karlović
Although depressive symptoms seem to be frequent in schizophrenia they have received significantly less attention than other symptom domains. As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia. Other objectives of this study were to closely examine schizophrenia symptom domains by performing factor analysis of the two most used instruments in this setting (Positive and negative syndrome scale - PANSS and Calgary depression rating scale - CDSS) and to examine the influence of investigated gene polymorphisms on the schizophrenia symptom domains, focusing on depressive scores...
April 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28368213/association-between-comt-val158met-polymorphism-and-competition-results-of-competitive-swimmers
#14
Daisuke Abe, Hirokazu Doi, Taishi Asai, Mayuko Kimura, Tadashi Wada, Yuusuke Takahashi, Takaaki Matsumoto, Kazuyuki Shinohara
Recent studies have shown the contribution of genetic determinants to athletes' physical ability. However, despite the fact that cognitive abilities like self-control and stress-tolerance influence athletes' competitive performance, few studies to date have investigated the association between genetic polymorphism, which is linked to cognitive ability and athletic performance. The present study investigated the link between single-nucleotide polymorphisms (SNPs), which are known to exert influences on dopaminergic neural function and competitive performance of swimmers...
April 3, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28356882/protective-role-of-maternal-p-val158met-catechol-o-methyltransferase-polymorphism-against-early-onset-preeclampsia-and-its-complications
#15
Tijana Krnjeta, Ljiljana Mirković, Svetlana Ignjatović, Dragana Tomašević, Jelena Lukić, Drina Topalov, Ivan Soldatović, Nada Majkić-Singh
BACKGROUND: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestational-age (SGA) complicating PE. METHODS: The study included 47 early-onset PE patients and 47 control cases...
September 2016: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28288405/the-association-between-well-being-and-the-comt-gene-dispositional-gratitude-and-forgiveness-as-mediators
#16
Jinting Liu, Pingyuan Gong, Xiaoxue Gao, Xiaolin Zhou
BACKROUND: Previous studies have demonstrated the contributions of genetic variants and positive psychological traits (e.g. gratitude and forgiveness) to well-being. However, little is known about how genes interact with positive traits to affect well-being. METHODS: To investigate to what extent the COMT Val158Met polymorphism modulates well-being and to what extent dispositional gratitude and forgiveness mediate the individual differences in well-being, 445 participants were recruited and required to complete a battery of questionnaires...
May 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28262436/gene-environment-interaction-as-a-predictor-of-early-adjustment-in-first-episode-psychosis
#17
David Fraguas, Covadonga M Díaz-Caneja, Iluminada Corripio, Ana González-Pinto, Antonio Lobo, Miquel Bioque, Manuel J Cuesta, Julio Sanjuán, Elisa Rodríguez-Toscano, Bárbara Arias, Salvador Sarró, Bibiana Cabrera, Antoni Bulbena, Eduard Vieta, Josefina Castro-Fornieles, Celso Arango, Miquel Bernardo, Mara Parellada
BACKGROUND: This study aims to explore the gene-environment interaction hypothesis applied to pre-symptomatic neurodevelopmental phenotypes of first episode psychosis (FEP), that is, genetic factors might increase vulnerability to the effects of environmental adverse conditions occurring at later stages of development. METHODS: We constructed a schematic 'two-hit' model, with Val/Val homozygosity for the catechol-O-methyltransferase (COMT) Val158Met polymorphism as the 'first hit' and history of obstetric complications and parental socioeconomic status as 'second hits'...
March 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28252569/comt-val158met-polymorphism-and-symptom-improvement-following-a-cognitively-focused-intervention-for-irritable-bowel-syndrome
#18
Claire J Han, Ruth Kohen, Sangeun Jun, Monica E Jarrett, Kevin C Cain, Robert Burr, Margaret M Heitkemper
BACKGROUND: Our nurse-delivered comprehensive self-management (CSM) program, a cognitive behavioral therapy intervention, is effective in reducing gastrointestinal and psychological distress symptoms in patients with irritable bowel syndrome (IBS). Findings from non-IBS studies indicate that the catechol-O-methyltransferase (COMT) Val158Met polymorphism may moderate the efficacy of cognitive behavioral therapy. It is unknown whether this COMT polymorphism is associated with symptom improvements in patients with IBS...
March 2017: Nursing Research
https://www.readbyqxmd.com/read/28235603/val158met-polymorphism-in-the-comt-gene-is-associated-with-hypersomnia-and-mental-health-related-quality-of-life-in-a-colombian-sample
#19
Karen M Jiménez, Angela J Pereira-Morales, Diego A Forero
The identification of genes that are risk factors for major depressive disorder remains a main task for global psychiatric research. The Catechol-O-methyltransferase (COMT) gene has been an important candidate risk factor for several psychiatric disorders. Previous studies have shown that a functional polymorphism (Val158Met) in this gene has an effect on several brain circuits and endophenotypes of psychiatric relevance. The aim of this study was to explore the association of a functional polymorphism in the COMT gene with psychological distress, sleep problems and health-related quality of life...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28157646/polymorphism-in-xenobiotic-and-estrogen-metabolizing-genes-exposure-to-perfluorinated-compounds-and-subsequent-breast-cancer-risk-a-nested-case-control-study-in-the-danish-national-birth-cohort
#20
Mandana Ghisari, Manhai Long, Durita Mohr Røge, Jørn Olsen, Eva C Bonefeld-Jørgensen
In the present case-cohort study based on prospective data from Danish women, we aimed to estimate the main effect of polymorphisms in genes known to be involved in the steroid hormone metabolic pathway and xenobiotic metabolism on the risk of developing breast cancer. We also studied a possible effect measure modification between genotypes and levels of serum perfluoroalkylated substances (PFASs) on the risk to breast cancer. We have previously reported a weak association between serum PFASs levels and the risk of breast cancer for this study population of Danish pregnant nulliparous women as well as in a smaller case-control study of Greenlandic women...
April 2017: Environmental Research
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