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COMT Val158Met

Jiayuan Xu, Wen Qin, Qiaojun Li, Wei Li, Feng Liu, Bing Liu, Tianzi Jiang, Chunshui Yu
There exist gender differences in the modulation of catechol-O-methyltransferase (COMT) Val158Met polymorphism on cognitive performance; however, the underlying gene-anatomy-cognition pathways remain unknown. Here we hypothesize that prefrontal volume may mediate the modulation of COMT Val158Met polymorphism on interference resolution capacity in a gender-dependent manner. In 261 healthy young human subjects (143 males and 118 females), a 2-way analysis of variance showed a COMT × gender interaction (P = 0...
September 24, 2016: Cerebral Cortex
Xiaohua Zhao, Jingjing Liu, Cuisheng Zhao, Ping Ye, Jing Ji, Jingli Wang, Weiqing Song, Jine Xu, Shiguo Liu
OBJECTIVE: Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women. METHOD: A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR ...
September 19, 2016: Hypertension in Pregnancy
Bei Wang, Wenzhao Ru, Xing Yang, Lu Yang, Pengpeng Fang, Xu Zhu, Guomin Shen, Xiaocai Gao, Pingyuan Gong
Dopamine levels in the brain influence human consciousness. Inspired by the role of Catechol-O-methyltransferase (COMT) in inactivating dopamine in the brain, we investigated to what extent COMT could modulate individual's self-consciousness dispositions and self-consistency by genotyping the COMT Val158Met (rs4680) polymorphism and measuring self-consciousness and self-consistency and congruence in a college student population. The results indicated that COMT Val158Met polymorphism significantly modulated the private self-consciousness...
August 2016: Consciousness and Cognition
Lyailya Kh Dzhemlikhanova, Olga A Efimova, Natalia S Osinovskaya, Sergey E Parfenyev, Dariko A Niauri, Iskender Yu Sultanov, Olga V Malysheva, Anna A Pendina, Natalia Yu Shved, Tatyana E Ivashchenko, Maria I Yarmolinskaya, Maka I Kakhiani, Ekaterina A Gorovaya, Antonina N Tkachenko, Vladislav S Baranov
AIMS: To study the possible association of catechol-O-methyltransferase (COMT) Val158Met polymorphism with multiple and solitary uterine leiomyomas (ULs) and to check whether the COMT Val/Val genotype is associated with MED12 exon 2 mutations in fibroids. METHODS: The COMT Val158Met allele and genotype frequencies were compared between age-matched women with ULs (n=104) and controls (n=59). Patients with UL were subcategorised by diagnosis of solitary (n=59) or multiple (n=45) fibroids and by the presence of somatic MED12 exon 2 mutations in at least one fibroid (n=32) or in neither fibroid (n=26)...
August 4, 2016: Journal of Clinical Pathology
Zhi Li, Beate W Hygen, Keith F Widaman, Turid S Berg-Nielsen, Lars Wichstrøm, Jay Belsky
Why is disorganized attachment associated with punitive-controlling behavior in some, but caregiving-controlling in others? Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect. We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development. As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis...
2016: Frontiers in Psychology
Yvette N Lamb, Nicole S McKay, Shrimal S Singh, Karen E Waldie, Ian J Kirk
The catechol-O-methyltransferase (COMT) val158met polymorphism affects the breakdown of synaptic dopamine. Consequently, this polymorphism has been associated with a variety of neurophysiological and behavioral outcomes. Some of the effects have been found to be sex-specific and it appears estrogen may act to down-regulate the activity of the COMT enzyme. The dopaminergic system has been implicated in face recognition, a form of cognition for which a female advantage has typically been reported. This study aimed to investigate potential joint effects of sex and COMT genotype on face recognition...
2016: Frontiers in Psychology
Rajesh Narendran, Divya Tumuluru, Maureen A May, Kodavali V Chowdari, Michael L Himes, Kelli Fasenmyer, W Gordon Frankle, Vishwajit L Nimgaonkar
Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex. Previous PET studies have documented the relationship between COMT Val158Met polymorphism and D1 and D2/3 receptor binding potential (BP), and interpreted them in terms of dopaminergic tone. The use of baseline dopamine D1 and D2/3 receptor binding potential (BPND) as a proxy for dopaminergic tone is problematic because they reflect both endogenous dopamine levels (a change in radiotracer's apparent affinity) and receptor density...
2016: PloS One
J P Schacht
The relationship between dopamine (DA) tone in the prefrontal cortex (PFC) and PFC-dependent cognitive functions (for example, working memory, selective attention, executive function) may be described by an inverted-U-shaped function, in which both excessively high and low DA is associated with impairment. In the PFC, the COMT val158met single nucleotide polymorphism (rs4680) confers differences in catechol-O-methyltransferase (COMT) efficacy and DA tone, and individuals homozygous for the val allele display significantly reduced cortical DA...
October 2016: Pharmacogenomics Journal
Jaclyn A Stephens, Marian E Berryhill
BACKGROUND: Aging is associated with decline in executive function (EF), upper-level cognitive abilities such as planning, problem solving, and working memory (WM). This decline is associated with age-related volume loss and reduced functional connectivity in the frontal lobes. Cognitive training interventions aim to counter these losses, but often fail to elicit benefits beyond improvements on trained tasks. Recent interventions pairing WM training with transcranial direct current stimulation (tDCS) have improved WM and elicited transfer to untrained EF tasks...
July 2016: Brain Stimulation
Yao-Jun Liao, Jing-Ru Jiang, San-Qing Jin
BACKGROUND: The COMT Val158Met polymorphism has long been regarded as a risk factor for migraine. The possible association between COMT Val158Met polymorphism and migraine has been evaluated in several studies, but the results are not consistent. Therefore, we conduct this meta-analysis to address these issues. METHODS: The WEB OF SCIENCE and EMBASE databases were searched for eligible studies. The odds ratio (OR) with the corresponding 95% confidence interval (CI) was calculated to estimate the strength of the association between COMT Val158Met polymorphism and migraine...
May 6, 2016: Cephalalgia: An International Journal of Headache
John M Myrga, Shannon B Juengst, Michelle D Failla, Yvette P Conley, Patricia M Arenth, Anthony A Grace, Amy K Wagner
OBJECTIVE: Genetic variations in the dopamine (DA) system are associated with cortical-striatal behavior in multiple populations. This study assessed associations of functional polymorphisms in the ankyrin repeat and kinase domain (ANKK1; Taq1a) and catechol-O-methyltransferase (COMT; Val158Met) genes with behavioral dysfunction following traumatic brain injury (TBI). PARTICIPANTS: This was a prospective study of 90 survivors of severe TBI recruited from a level 1 trauma center...
May 6, 2016: Neurorehabilitation and Neural Repair
Philippe Jawinski, Sophie Tegelkamp, Christian Sander, Madlen Häntzsch, Jue Huang, Nicole Mauche, Markus Scholz, Janek Spada, Christine Ulke, Ralph Burkhardt, Andreas Reif, Ulrich Hegerl, Tilman Hensch
Dopamine has been implicated in the regulation of sleep-wake states and the circadian rhythm. However, there is no consensus on the impact of two established dopaminergic gene variants: the catechol-O-methyltransferase Val158Met (COMT Val158Met; rs4680) and the dopamine D4 receptor Exon III variable-number-of-tandem-repeat polymorphism (DRD4 VNTR). Pursuing a multi-method approach, we examined their potential effects on circadian preferences, arousal regulation and sleep. Subjects underwent a 7-day actigraphy assessment (SenseWear Pro3), a 20-minute resting EEG (analyzed using VIGALL 2...
2016: Chronobiology International
N S Corral-Frías, D A Pizzagalli, J M Carré, L J Michalski, Y S Nikolova, R H Perlis, J Fagerness, M R Lee, E Drabant Conley, T M Lancaster, S Haddad, A Wolf, J W Smoller, A R Hariri, R Bogdan
Identifying mechanisms through which individual differences in reward learning emerge offers an opportunity to understand both a fundamental form of adaptive responding as well as etiological pathways through which aberrant reward learning may contribute to maladaptive behaviors and psychopathology. One candidate mechanism through which individual differences in reward learning may emerge is variability in dopaminergic reinforcement signaling. A common functional polymorphism within the catechol-O-methyl transferase gene (COMT; rs4680, Val(158) Met) has been linked to reward learning, where homozygosity for the Met allele (linked to heightened prefrontal dopamine function and decreased dopamine synthesis in the midbrain) has been associated with relatively increased reward learning...
June 2016: Genes, Brain, and Behavior
Onder Ozturk, Huseyin Alacam, Burge Kabukcu Basay, Omer Basay, Ahmet Buber, Ozlem Izci Ay, Kadir Agladıoglu, Mehmet Emin Erdal, Hasan Herken
OBJECTIVE: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Thus, the present study aimed to determine the effects of a single dose of methylphenidate (Mph) on neurometabolite levels according to polymorphisms of the catechol-O-methyltransferase (COMT) gene. METHODS: This study evaluated the neurometabolite levels including N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) of ADHD patients, before and after treatment with Mph (10 mg) according to the presence of COMT polymorphisms...
May 31, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Bulent Turan, Tamara Sims, Sasha E Best, Laura L Carstensen
The catechol-O-methyltransferase (COMT_Val158Met) genetic polymorphism has been linked to variation in affective well-being. Compared with Val carriers, Met carriers experience lower affective well-being. In parallel, research on aging and affective experience finds that younger adults experience poorer affective well-being than older adults. This study examined how COMT and age may interact to shape daily affective experience across the life span. Results suggest that Met (vs. Val) carriers experience lower levels of affective well-being in younger but not in older ages...
May 2016: Psychology and Aging
Denise D Correa, Jaya Satagopan, Kenneth Cheung, Arshi K Arora, Maria Kryza-Lacombe, Youming Xu, Sasan Karimi, John Lyo, Lisa M DeAngelis, Irene Orlow
BACKGROUND: Cognitive dysfunction is common among patients with brain tumors and can be associated with the disease and treatment with radiotherapy and chemotherapy. However, little is known about genetic risk factors that may moderate the vulnerability for developing cognitive dysfunction. In this study, we examined the association of single nucleotide polymorphisms (SNPs) in the catechol-O-methyl transferase (COMT), brain-derived neurotrophic factor (BDNF), and dystrobrevin-binding protein 1 (DTNBP1) genes with cognitive functions and neuroimaging outcomes in patients with brain tumors...
October 2016: Neuro-oncology
Janine J Benson-Martin, Dan J Stein, David S Baldwin, Katharina Domschke
Electroconvulsive therapy (ECT) is known to be one of the most effective treatments for managing depression and other severe mental illnesses. Nevertheless, the exact mechanisms underlying response to ECT remain uncertain. This mini-review presents clinical findings regarding the role of genetic factors in the aetiology of the ECT response. Studies on the role of variation in the catechol-O-methyltransferase (COMT) gene; other dopamine-, serotonin-, and G-protein-related genes; brain-derived neurotrophic factor (BDNF); apolipoprotein E (APOE); angiotensin I-converting enzyme (ACE) and vascular endothelial growth factor (VEGF) genes in mediating response to ECT are summarized...
May 2016: Human Psychopharmacology
Yang Chen, Xiaoxiang Yu, Tianyu Li, Haibiao Yan, Zengnan Mo
BACKGROUND: Urological cancers occur worldwide. Many factors, among which the catechol-O-methyltransferase (COMT) Val158Met polymorphism, are said to be associated with the cancer risk. We conducted a meta-analysis to investigate the association between urological cancer susceptibility and COMT Val158Met in different genetic models. METHODS: This study was based on material obtained from the PubMed, HuGENet and Embase databases. Four models including dominant (AA + AG vs...
2016: International Journal of Biological Markers
Jessica S Damoiseaux, Raymond P Viviano, Peng Yuan, Naftali Raz
Aging is associated with declines in cognitive performance and multiple changes in the brain, including reduced default mode functional connectivity (FC). However, conflicting results have been reported regarding age differences in FC between hippocampal and default mode regions. This discrepancy may stem from the variation in selection of hippocampal regions. We therefore examined the effect of age on resting state FC of anterior and posterior hippocampal regions in an adult life-span sample. Advanced age was associated with lower FC between the posterior hippocampus and three regions: the posterior cingulate cortex, medial prefrontal cortex, and lateral parietal cortex...
June 2016: NeuroImage
Abhay A Shukla, Manish Jha, Thomas Birchfield, Shibani Mukherjee, Kelly Gleason, Salim Abdisalaam, Aroumougame Asaithamby, Beverley Adams-Huet, Carol A Tamminga, Subroto Ghose
The single nucleotide val158met polymorphism in catechol o-methyltransferase (COMT) influences prefrontal cortex function. Working memory, dependent on the dorsolateral prefrontal cortex (DLPFC), has been repeatedly shown to be influenced by this COMT polymorphism. The high activity COMT val isoform is associated with lower synaptic dopamine levels. Altered synaptic dopamine levels are expected to lead to molecular adaptations within the synapse and within DLPFC neural circuitry. In this human post mortem study using high quality DLPFC tissue, we first examined the influence of the COMT val158met polymorphism on markers of dopamine neurotransmission, N-methyl-d-aspartate (NMDA) receptor subunits and glutamatic acid decarboxylase 67 (GAD67), all known to be critical to DLPFC circuitry and function...
May 2016: Schizophrenia Research
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