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COMT Val158Met

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https://www.readbyqxmd.com/read/28288405/the-association-between-well-being-and-the-comt-gene-dispositional-gratitude-and-forgiveness-as-mediators
#1
Jinting Liu, Pingyuan Gong, Xiaoxue Gao, Xiaolin Zhou
BACKROUND: Previous studies have demonstrated the contributions of genetic variants and positive psychological traits (e.g. gratitude and forgiveness) to well-being. However, little is known about how genes interact with positive traits to affect well-being. METHODS: To investigate to what extent the COMT Val158Met polymorphism modulates well-being and to what extent dispositional gratitude and forgiveness mediate the individual differences in well-being, 445 participants were recruited and required to complete a battery of questionnaires...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28262436/gene-environment-interaction-as-a-predictor-of-early-adjustment-in-first-episode-psychosis
#2
David Fraguas, Covadonga M Díaz-Caneja, Iluminada Corripio, Ana González-Pinto, Antonio Lobo, Miquel Bioque, Manuel J Cuesta, Julio Sanjuán, Elisa Rodríguez-Toscano, Bárbara Arias, Salvador Sarró, Bibiana Cabrera, Antoni Bulbena, Eduard Vieta, Josefina Castro-Fornieles, Celso Arango, Miquel Bernardo, Mara Parellada
BACKGROUND: This study aims to explore the gene-environment interaction hypothesis applied to pre-symptomatic neurodevelopmental phenotypes of first episode psychosis (FEP), that is, genetic factors might increase vulnerability to the effects of environmental adverse conditions occurring at later stages of development. METHODS: We constructed a schematic 'two-hit' model, with Val/Val homozygosity for the catechol-O-methyltransferase (COMT) Val158Met polymorphism as the 'first hit' and history of obstetric complications and parental socioeconomic status as 'second hits'...
March 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28252569/comt-val158met-polymorphism-and-symptom-improvement-following-a-cognitively-focused-intervention-for-irritable-bowel-syndrome
#3
Claire J Han, Ruth Kohen, Sangeun Jun, Monica E Jarrett, Kevin C Cain, Robert Burr, Margaret M Heitkemper
BACKGROUND: Our nurse-delivered comprehensive self-management (CSM) program, a cognitive behavioral therapy intervention, is effective in reducing gastrointestinal and psychological distress symptoms in patients with irritable bowel syndrome (IBS). Findings from non-IBS studies indicate that the catechol-O-methyltransferase (COMT) Val158Met polymorphism may moderate the efficacy of cognitive behavioral therapy. It is unknown whether this COMT polymorphism is associated with symptom improvements in patients with IBS...
March 2017: Nursing Research
https://www.readbyqxmd.com/read/28235603/val158met-polymorphism-in-the-comt-gene-is-associated-with-hypersomnia-and-mental-health-related-quality-of-life-in-a-colombian-sample
#4
Karen M Jiménez, Angela J Pereira-Morales, Diego A Forero
The identification of genes that are risk factors for major depressive disorder remains a main task for global psychiatric research. The Catechol-O-methyltransferase (COMT) gene has been an important candidate risk factor for several psychiatric disorders. Previous studies have shown that a functional polymorphism (Val158Met) in this gene has an effect on several brain circuits and endophenotypes of psychiatric relevance. The aim of this study was to explore the association of a functional polymorphism in the COMT gene with psychological distress, sleep problems and health-related quality of life...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28157646/polymorphism-in-xenobiotic-and-estrogen-metabolizing-genes-exposure-to-perfluorinated-compounds-and-subsequent-breast-cancer-risk-a-nested-case-control-study-in-the-danish-national-birth-cohort
#5
Mandana Ghisari, Manhai Long, Durita Mohr Røge, Jørn Olsen, Eva C Bonefeld-Jørgensen
In the present case-cohort study based on prospective data from Danish women, we aimed to estimate the main effect of polymorphisms in genes known to be involved in the steroid hormone metabolic pathway and xenobiotic metabolism on the risk of developing breast cancer. We also studied a possible effect measure modification between genotypes and levels of serum perfluoroalkylated substances (PFASs) on the risk to breast cancer. We have previously reported a weak association between serum PFASs levels and the risk of breast cancer for this study population of Danish pregnant nulliparous women as well as in a smaller case-control study of Greenlandic women...
April 2017: Environmental Research
https://www.readbyqxmd.com/read/28142064/cannabis-use-comt-bdnf-and-age-at-first-episode-psychosis
#6
Anna Mané, Daniel Bergé, Maria Jose Penzol, Mara Parellada, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Iluminada Corripio, Bibiana Cabrera, Ana Maria Sánchez-Torres, Jerónimo Saiz-Ruiz, Miguel Bernardo, PEPs Group
Although an interaction between COMT Val158Met and BDNF Val66Met polymorphisms with cannabis use has been proposed with respect to the risk of psychosis emergence, findings remain inconclusive. The aim of the present study was to evaluate the different possible associations between these polymorphisms and early cannabis use and the age at the first episode of psychosis. The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated...
April 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28120105/age-differences-in-arterial-and-venous-extra-cerebral-blood-flow-in-healthy-adults-contributions-of-vascular-risk-factors-and-genetic-variants
#7
Naftali Raz, Ana M Daugherty, Sean K Sethi, Muzamil Arshad, E Mark Haacke
Sufficient cerebral blood flow (CBF) and venous drainage are critical for normal brain function, and their alterations can affect brain aging. However, to date, most studies focused on arterial CBF (inflow) with little attention paid to the age differences in venous outflow. We measured extra-cerebral arterial and venous blood flow rates with phase-contrast MRI and assessed the influence of vascular risk factors and genetic polymorphisms (ACE insertion/deletion, COMT val158met, and APOEε4) in 73 adults (age 18-74 years)...
January 24, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28089731/investigation-of-polymorphisms-in-genes-involved-in-estrogen-metabolism-in-menstrual-migraine
#8
Heidi G Sutherland, Morgane Champion, Amelie Plays, Shani Stuart, Larisa M Haupt, Alison Frith, E Anne MacGregor, Lyn R Griffiths
Migraine is a common, disabling headache disorder, which is influenced by multiple genes and environmental triggers. After puberty, the prevalence of migraine in women is three times higher than in men and >50% of females suffering from migraine report a menstrual association, suggesting hormonal fluctuations can influence the risk of migraine attacks. It has been hypothesized that the drop in estrogen during menses is an important trigger for menstrual migraine. Catechol-O-methyltransferase (COMT) and Cytochrome P450 (CYP) enzymes are involved in estrogen synthesis and metabolism...
April 5, 2017: Gene
https://www.readbyqxmd.com/read/27930497/the-comt-val158met-polymorphism-is-associated-with-response-to-add-on-dextromethorphan-treatment-in-bipolar-disorder
#9
Sheng-Yu Lee, Shiou-Lan Chen, Tzu-Yun Wang, Yun-Hsuan Chang, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Kao Ching Chen, Yen Kuang Yang, Ru-Band Lu
PURPOSE/BACKGROUND: We previously conducted a randomized, double-blind, controlled, 12-week study evaluating the effect of add-on dextromethorphan (DM), a noncompetitive N-methyl-D-aspartate receptor antagonist, on patients with bipolar disorder (BD) treated using valproate (VPA), which showed negative clinical differences. The genetic variation between each individual may be responsible for interindividual differences. The catechol-O-methyltransferase (COMT) gene has been a candidate gene for BD...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27909011/age-dependent-effects-of-catechol-o-methyltransferase-comt-gene-val158met-polymorphism-on-language-function-in-developing-children
#10
Lisa Sugiura, Tomoko Toyota, Hiroko Matsuba-Kurita, Yoshimi Iwayama, Reiko Mazuka, Takeo Yoshikawa, Hiroko Hagiwara
The genetic basis controlling language development remains elusive. Previous studies of the catechol-O-methyltransferase (COMT) Val(158)Met genotype and cognition have focused on prefrontally guided executive functions involving dopamine. However, COMT may further influence posterior cortical regions implicated in language perception. We investigated whether COMT influences language ability and cortical language processing involving the posterior language regions in 246 children aged 6-10 years. We assessed language ability using a language test and cortical responses recorded during language processing using a word repetition task and functional near-infrared spectroscopy...
November 30, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27898499/comt-and-bdnf-gene-variants-help-to-predict-alcohol-consumption-in-alcohol-dependent-patients
#11
Anna Klimkiewicz, Anna Mach, Andrzej Jakubczyk, Jakub Klimkiewicz, Anna Wnorowska, Maciej Kopera, Sylwia Fudalej, Margit Burmeister, Kirk Brower, Marcin Wojnar
BACKGROUND: The neurobiology of alcohol dependence (AD) involves alterations in neurotransmitters and the stress response. We hypothesized that an interaction between functional variants of dopaminergic and neurotrophic genes may influence drinking in AD. METHODS: The relationship between alcohol consumption and single-nucleotide polymorphisms, Val66Met in the brain-derived neurotrophic factor (BDNF), and Val158Met in the catechol-O-methyltransferase (COMT), was analyzed among 281 alcohol-dependent individuals...
March 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27826992/the-val158met-polymorphism-in-comt-gene-and-cancer-risk-role-of-endogenous-and-exogenous-catechols
#12
Katrin Sak
Catechol-O-methyltransferase, COMT, is an important phase II enzyme catalyzing the transfer of a methyl-group from S-adenosylmethionine to a catechol-containing substrate molecule. A genetic variant Val158Met in the COMT gene leads to a several-fold decrease in the enzymatic activity giving rise to the accumulation of potentially carcinogenic endogenous catechol estrogens and their reactive intermediates and increasing thus the risk of tumorigenesis. However, numerous association studies between the COMT genotype and susceptibility to various malignancies have shown inconsistent and controversial findings indicating that additional gene-gene and gene-environment interactions might be crucial in modulating the physiological role of the COMT...
November 23, 2016: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27825784/does-comt-val158met-polymorphism-influence-p50-sensory-gating-eye-tracking-or-saccadic-inhibition-dysfunctions-in-schizophrenia
#13
Caroline Demily, Sandrine Louchart-de-la-Chapelle, Irène Nkam, Nicolas Ramoz, Pierre Denise, Alain Nicolas, Caroline Savalle, Florence Thibaut
Three electrophysiological endophenotypes are routinely studied in schizophrenia (SCZ): smooth pursuit eye movement (SPEM) dysfunction, deficits in P50 auditory-evoked potential inhibition, and saccadic inhibition deficits. The current study aimed to investigate the relationship between the COMT val158met polymorphism and these three endophenotypes. One hundred four SCZ patients (DSM-IV-R criteria) and 89 healthy controls were included in this study. P50 auditory-evoked potential inhibition, antisaccade paradigm and SPEM were analyzed...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27785396/association-between-the-catechol-o-methyltransferase-val158met-polymorphism-with-susceptibility-and-severity-of-carpal-tunnel-syndrome
#14
E Erkol İnal, P Eroğlu, O Görükmez, Ş Özemri Sağ, T Yakut
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity. In this study, we aimed to clarify the relationships between the catechol-O-methyltransferase (COMT) gene Val158Met (rs4680) polymorphism and development, functional and clinical status of CTS. Ninety-five women with electro diagnostically confirmed CTS and 95 healthy controls were enrolled in the study. The functional and clinical status of the patients was measured by the Turkish version of the Boston Questionnaire and intensity of pain related to the past 2 weeks was evaluated on a visual analog scale (VAS)...
December 1, 2015: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/27664968/prefrontal-volume-mediates-effect-of-comt-polymorphism-on-interference-resolution-capacity-in-healthy-male-adults
#15
Jiayuan Xu, Wen Qin, Qiaojun Li, Wei Li, Feng Liu, Bing Liu, Tianzi Jiang, Chunshui Yu
There exist gender differences in the modulation of catechol-O-methyltransferase (COMT) Val158Met polymorphism on cognitive performance; however, the underlying gene-anatomy-cognition pathways remain unknown. Here we hypothesize that prefrontal volume may mediate the modulation of COMT Val158Met polymorphism on interference resolution capacity in a gender-dependent manner. In 261 healthy young human subjects (143 males and 118 females), a 2-way analysis of variance showed a COMT × gender interaction (P = 0...
September 24, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27646972/association-between-comt-val158met-polymorphism-and-preeclampsia-in-the-chinese-han-population
#16
Xiaohua Zhao, Jingjing Liu, Cuisheng Zhao, Ping Ye, Jing Ji, Jingli Wang, Weiqing Song, Jine Xu, Shiguo Liu
OBJECTIVE: Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women. METHOD: A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR ...
November 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27522491/catechol-o-methyltransferase-comt-gene-modulates-private-self-consciousness-and-self-flexibility
#17
Bei Wang, Wenzhao Ru, Xing Yang, Lu Yang, Pengpeng Fang, Xu Zhu, Guomin Shen, Xiaocai Gao, Pingyuan Gong
Dopamine levels in the brain influence human consciousness. Inspired by the role of Catechol-O-methyltransferase (COMT) in inactivating dopamine in the brain, we investigated to what extent COMT could modulate individual's self-consciousness dispositions and self-consistency by genotyping the COMT Val158Met (rs4680) polymorphism and measuring self-consciousness and self-consistency and congruence in a college student population. The results indicated that COMT Val158Met polymorphism significantly modulated the private self-consciousness...
August 2016: Consciousness and Cognition
https://www.readbyqxmd.com/read/27491313/catechol-o-methyltransferase-val158met-polymorphism-is-associated-with-increased-risk-of-multiple-uterine-leiomyomas-either-positive-or-negative-for-med12-exon-2-mutations
#18
Lyailya Kh Dzhemlikhanova, Olga A Efimova, Natalia S Osinovskaya, Sergey E Parfenyev, Dariko A Niauri, Iskender Yu Sultanov, Olga V Malysheva, Anna A Pendina, Natalia Yu Shved, Tatyana E Ivashchenko, Maria I Yarmolinskaya, Maka I Kakhiani, Ekaterina A Gorovaya, Antonina N Tkachenko, Vladislav S Baranov
AIMS: To study the possible association of catechol-O-methyltransferase (COMT) Val158Met polymorphism with multiple and solitary uterine leiomyomas (ULs) and to check whether the COMT Val/Val genotype is associated with MED12 exon 2 mutations in fibroids. METHODS: The COMT Val158Met allele and genotype frequencies were compared between age-matched women with ULs (n=104) and controls (n=59). Patients with UL were subcategorised by diagnosis of solitary (n=59) or multiple (n=45) fibroids and by the presence of somatic MED12 exon 2 mutations in at least one fibroid (n=32) or in neither fibroid (n=26)...
March 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27462283/disorganization-comt-and-children-s-social-behavior-the-norwegian-hypothesis-of-legacy-of-disorganized-attachment
#19
Zhi Li, Beate W Hygen, Keith F Widaman, Turid S Berg-Nielsen, Lars Wichstrøm, Jay Belsky
Why is disorganized attachment associated with punitive-controlling behavior in some, but caregiving-controlling in others? Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect. We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development. As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27445927/catechol-o-methyltransferase-val-158-met-polymorphism-interacts-with-sex-to-affect-face-recognition-ability
#20
Yvette N Lamb, Nicole S McKay, Shrimal S Singh, Karen E Waldie, Ian J Kirk
The catechol-O-methyltransferase (COMT) val158met polymorphism affects the breakdown of synaptic dopamine. Consequently, this polymorphism has been associated with a variety of neurophysiological and behavioral outcomes. Some of the effects have been found to be sex-specific and it appears estrogen may act to down-regulate the activity of the COMT enzyme. The dopaminergic system has been implicated in face recognition, a form of cognition for which a female advantage has typically been reported. This study aimed to investigate potential joint effects of sex and COMT genotype on face recognition...
2016: Frontiers in Psychology
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