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COMT Val158Met

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https://www.readbyqxmd.com/read/29627597/genetic-pathways-to-posttraumatic-stress-disorder-and-depression-in-children-investigation-of-catechol-o-methyltransferase-comt-val158met-using-different-ptsd-diagnostic-models
#1
BreAnne A Danzi, Annette M La Greca
The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been linked to PTSD, although findings have been inconsistent. Recently, different diagnostic criteria for PTSD have been introduced by ICD-11 and DSM-5, including separate criteria for adults and for young children (i.e., the preschool criteria). The preschool criteria may be applicable to older children as well. This study is the first to examine COMT associations with depression and PTSD, using new diagnostic models, in school-age children (7-11 years) exposed to a natural disaster...
March 27, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29594134/the-comt-val158met-polymorphism-and-exploratory-behavior-in-bipolar-mania
#2
Arpi Minassian, Jared W Young, Mark A Geyer, John R Kelsoe, William Perry
Background: The catechol-O-methyltransferase (COMT) Val158Met gene influences cognition and behavior in psychiatric illnesses; its low-activity allele, methionine (Met), may be associated with behavior reflecting catecholamine overactivity. Heightened motor activity and increased positive valence are central features of bipolar disorder (BD) and have been quantified in the human Behavioral Pattern Monitor (hBPM), an exploration paradigm based upon the rodent open field. We examined whether hBPM behavior was related to the COMT gene in a small sample of manic BD patients...
February 2018: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29574383/interplay-between-comt-val158met-childhood-adversities-and-sex-in-predicting-panic-pathology-findings-from-a-general-population-sample
#3
Eva Asselmann, Johannes Hertel, Katja Beesdo-Baum, Carsten-Oliver Schmidt, Georg Homuth, Matthias Nauck, Hans-Jörgen Grabe, Christiane A Pané-Farré
BACKGROUND: The single nucleotide polymorphism rs4680 of the catechol-O-methyltransferase (COMT) gene has been implicated to be involved in the etiopathogenesis of panic. However, it remains unresolved whether rs4680 modifies the risk-association between early life stress and subsequent development of panic pathology. METHODS: The genotype of rs4680 was determined for n = 2242 adults with European ancestry from the Study of Health in Pomerania (SHIP, a regional longitudinal cohort study from northeastern Germany)...
March 8, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29546858/cloninger-s-temperament-and-character-dimensions-and-dopaminergic-genes-dat1-vntr-and-comt-val158met-polymorphisms
#4
Ivana Glavina Jelaš, Ivan Dević, Dalibor Karlović
BACKGROUND: the objective of this study was to examine the associations between Cloninger temperament and character dimensions with the DAT1 VNTR and COMT Val158Met polymorphisms. SUBJECTS AND METHODS: The study was conducted on 101 subjects, consisting of students of the Police College in Zagreb and staff of the Sestre Milosrdnice University Hospital in Zagreb. The Cloninger Temperament and Character Inventory (TCI) was used to test personality traits. RESULTS: A main effect of the DAT1 VNTR polymorphism was found on the subscale self-directedness - SD2 (F=5...
March 2018: Psychiatria Danubina
https://www.readbyqxmd.com/read/29525179/genetic-markers-of-dopaminergic-transmission-predict-performance-for-older-males-but-not-females
#5
Kathleen E Hupfeld, David E Vaillancourt, Rachael D Seidler
Mobility and memory declines with aging can limit independence. Several single-nucleotide polymorphisms have been associated with cognitive performance, but studies investigating motor function are scant. We examined 4 single-nucleotide polymorphisms involved in dopaminergic metabolism: BDNF (Val66Met), DRD3 (Ser9Gly), DBH (C>T), and COMT (Val158Met) for their relationship to motor and cognitive function in healthy older adults (n = 4605 and n = 7331) who participated in the U.S. Health and Retirement Study...
February 10, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29510000/genetic-variations-exposure-to-persistent-organic-pollutants-and-breast-cancer-risk-a-greenlandic-case-control-study
#6
Maria Wielsøe, Hans Eiberg, Mandana Ghisari, Peder Kern, Ole Lind, Eva Cecilie Bonefeld-Jørgensen
The present study investigated the effects of single nucleotide polymorphisms (SNPs) in xenobiotic and steroid hormone-metabolizing genes in relation to breast cancer risk and explored possible effect modifications on persistent organic pollutants (POPs) and breast cancer associations. The study also assessed effects of Greenlandic BRCA1 founder mutations. Greenlandic Inuit women (77 cases and 84 controls) were included. We determined two founder mutations in BRCA1: Cys39Gly (rs80357164) and 4684delCC, and five SNPs in xenobiotic and oestrogen-metabolizing genes: CYP17A1 -34T>C (rs743572), CYP19A1 *19C>T (rs10046), CYP1A1 Ile462Val (rs1048943), CYP1B Leu432Val (rs1056836) and COMT Val158Met (rs4680)...
March 6, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29484256/catechol-o-methyltransferase-val158met-polymorphism-associates-with-affect-and-cortisol-levels-in-women
#7
Lauren D Hill, Margaret S Lorenzetti, Sarah M Lyle, Ana I Fins, Aurélien Tartar, Jaime L Tartar
Introduction: We tested the extent to which the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with affective state and evening cortisol levels. We limited our study to women as previous research suggests that the link between COMT genotype and psychological health is entangled by sex differences. Materials and Methods: The participants were assessed on measures of anxiety, mood disturbance, depressive symptomatology, and perceived stress...
February 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29472953/catechol-o-methyltransferase-comt-gene-val158met-and-brain-derived-neurotropic-factor-bdnf-val66met-genes-polymorphism-in-schizophrenia-a-case-control-study
#8
Ramin Saravani, Hamid Reza Galavi, Marzieh Lotfian Sargazi
Objective: Several studies have shown that some polymorphisms of genes encoding catechol-O-methyltransferase (COMT), the key enzyme in degrading dopamine, and norepinephrine and the human brain-derived neurotropic factor (BDNF), a nerve growth factor, are strong candidates for risk of schizophrenia (SCZ). In the present study, we aimed at examining the effects of COMT Val158Met (G>A) and BDNF Val66Met (G>A) polymorphisms on SCZ risk in a sample of Iranian population. Method: This case- control study included 92 SCZ patients and 92 healthy controls (HCs)...
October 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29472644/effects-of-comt-genotype-and-tolcapone-on-lapses-of-sustained-attention-after-sleep-deprivation-in-healthy-young-men
#9
Amandine Valomon, Sebastian C Holst, Alessandro Borrello, Susanne Weigend, Thomas Müller, Wolfgang Berger, Michael Sommerauer, Christian R Baumann, Hans-Peter Landolt
Tolcapone, a brain penetrant selective inhibitor of catechol-O-methyltransferase (COMT) devoid of psychostimulant properties, improves cognition and cortical information processing in rested volunteers, depending on the genotype of the functional Val158Met polymorphism of COMT. The impact of this common genetic variant on behavioral and neurophysiological markers of increased sleep need after sleep loss is controversial. Here we investigated the potential usefulness of tolcapone to mitigate consequences of sleep deprivation on lapses of sustained attention, and tested the hypothesis that dopamine signaling in the prefrontal cortex (PFC) causally contributes to neurobehavioral and neurophysiological markers of sleep homeostasis in humans...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29455339/analysis-of-comt-val158met-polymorphisms-and-methylation-in-chinese-male-schizophrenia-patients-with-homicidal-behavior
#10
Yikai Hu, Chenghu Li, Yangfan Wang, Qinhan Li, Yidong Liu, Shengde Liao, Peiqing Cao, Hongmei Xu
Schizophrenia is a severe mental disorder, and its mechanisms have not been fully elucidated. A functional single nucleotide polymorphism (SNP) present in the catechol-O-methyltransferase (COMT) gene, Val158Met (rs4680) (Chr22: 19,963,498), is possibly related to the violent behavior of schizophrenia patients. However, the specific variant that causes violent behavior is still unknown. Since the Val variation of Val158Met (rs4680) introduces a CG site into the sequence, the methylation level of the Val158Met (rs4680) region may also have an association with the homicidal behavior of schizophrenia patients...
February 17, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29444152/the-interaction-between-cannabis-use-and-the-val158met-polymorphism-of-the-comt-gene-in-psychosis-a-transdiagnostic-meta-analysis
#11
Thomas Stephanus Johannes Vaessen, Lea de Jong, Annika Theresia Schäfer, Thomas Damen, Aniek Uittenboogaard, Pauline Krolinski, Chinyere Vicky Nwosu, Florentina Maria Egidius Pinckaers, Iris Leah Marije Rotee, Antonius Petrus Wilhelmus Smeets, Ayşegül Ermiş, James L Kennedy, Dorien H Nieman, Arun Tiwari, Jim van Os, Marjan Drukker
BACKGROUND: Neither environmental nor genetic factors are sufficient to predict the transdiagnostic expression of psychosis. Therefore, analysis of gene-environment interactions may be productive. OBJECTIVE: A meta-analysis was performed using papers investigating the interaction between cannabis use and catechol-O-methyl transferase (COMT) polymorphism Val158Met (COMTVal158Met). DATA SOURCES: PubMed, Embase, PsychInfo. STUDY ELIGIBILITY CRITERIA: All observational studies assessing the interaction between COMTVal158Met and cannabis with any psychosis or psychotic symptoms measure as an outcome...
2018: PloS One
https://www.readbyqxmd.com/read/29427081/effects-of-tolcapone-and-bromocriptine-on-cognitive-stability-and-flexibility
#12
Ian G M Cameron, Deanna L Wallace, Ahmad Al-Zughoul, Andrew S Kayser, Mark D'Esposito
RATIONALE: The prefrontal cortex (PFC) and basal ganglia (BG) have been associated with cognitive stability and cognitive flexibility, respectively. We hypothesized that increasing PFC dopamine tone by administering tolcapone (a catechol-O-methyltransferase (COMT) inhibitor) to human subjects should promote stability; conversely, increasing BG dopamine tone by administering bromocriptine (a D2 receptor agonist) should promote flexibility. OBJECTIVE: We assessed these hypotheses by administering tolcapone, bromocriptine, and a placebo to healthy subjects who performed a saccadic eye movement task requiring stability and flexibility...
February 9, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29402857/association-between-comt-polymorphism-val158met-and-opioid-consumption-in-patients-with-postoperative-pain-a-meta-analysis
#13
Bo Hu, Xiaomin Zhang, Guangtao Xu, Qinmei Zhang, Ping Qian, Shengbing Liu, Jia Zhu, Ruilin Shen
BACKGROUND/AIMS: Several factors influencing postoperative pain and the effect of opioid analgesics have been investigated on an individual level. The aim of this study was to clarify the impact of catecholamine-O-methyltransferase (COMT) gene Val158Met on opioid consumption in postoperative patients. METHODS: A systematic review and meta-analysis of the literature up to September 30, 2017, were performed by using PubMed, Cochrane Library, ISI Web of Science, and Chinese National Knowledge Infrastructure (CNKI) database...
January 25, 2018: Neuro-Signals
https://www.readbyqxmd.com/read/29333880/pharmacogenetic-analysis-of-opioid-dependence-treatment-dose-and-dropout-rate
#14
Richard C Crist, James Li, Glenn A Doyle, Alex Gilbert, Bryan M Dechairo, Wade H Berrettini
BACKGROUND: Currently, no pharmacogenetic tests for selecting an opioid-dependence pharmacotherapy have been approved by the US Food and Drug Administration. OBJECTIVES: Determine the effects of variants in 11 genes on dropout rate and dose in patients receiving methadone or buprenorphine/naloxone (ClinicalTrials.gov Identifier: NCT00315341). METHODS: Variants in six pharmacokinetic genes (CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4) and five pharmacodynamic genes (HTR2A, OPRM1, ADRA2A, COMT, SLC6A4) were genotyped in samples from a 24-week, randomized, open-label trial of methadone and buprenorphine/naloxone for the treatment of opioid dependence (n = 764; 68...
January 15, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29314589/effect-of-the-comt-val158met-genotype-on-lateral-prefrontal-activations-in-young-children
#15
Yusuke Moriguchi, Ikuko Shinohara
Low executive function (EF) during early childhood is a major risk factor for developmental delay, academic failure, and social withdrawal. Susceptible genes may affect the molecular and biological mechanisms underpinning EF. More specifically, genes associated with the regulation of prefrontal dopamine may modulate the response of prefrontal neurons during executive control. Several studies with adults and older children have shown that variants of the catechol-O-methyltransferase (COMT) gene are associated with behavioral performance and prefrontal activations in EF tasks...
January 4, 2018: Developmental Science
https://www.readbyqxmd.com/read/29249680/dopaminergic-polymorphisms-associated-with-medication-responsiveness-of-gait-in-parkinson-s-disease
#16
Nathaniel S Miller, Kelvin L Chou, Nicolaas I Bohnen, Martijn L T M Müller, Rachael D Seidler
BACKGROUND: Gait dysfunction is a common symptom of Parkinson's disease that can cause significant disability and put patients at risk for falls. These symptoms show variable responsiveness to dopaminergic therapy. OBJECTIVE: To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease...
March 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29248857/catechol-o-methyltransferase-comt-genotype-affects-cognitive-control-during-total-sleep-deprivation
#17
Brieann C Satterfield, John M Hinson, Paul Whitney, Michelle A Schmidt, Jonathan P Wisor, Hans P A Van Dongen
Adaptive decision making is profoundly impaired by total sleep deprivation (TSD). This suggests that TSD impacts fronto-striatal pathways involved in cognitive control, where dopamine is a key neuromodulator. In the prefrontal cortex (PFC), dopamine is catabolized by the enzyme catechol-O-methyltransferase (COMT). A functional polymorphism (Val158Met) influences COMT's enzymatic activity, resulting in markedly different levels of prefrontal dopamine. We investigated the effect of this polymorphism on adaptive decision making during TSD...
February 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29247072/vascular-and-dopaminergic-contributors-to-mild-parkinsonian-signs-in-older-adults
#18
Andrea L Rosso, Nicolaas I Bohnen, Lenore J Launer, Howard J Aizenstein, Kristine Yaffe, Caterina Rosano
OBJECTIVE: Mild parkinsonian signs (MPS) are an underappreciated neurologic condition in older adults; we assessed associations of MPS with measures of dopaminergic (catechol-O-methyltransferase [COMT] genotype, an indicator of synaptic dopamine levels) and vascular (white matter hyperintensities [WMH], an indicator of cerebral small vessel disease) factors. METHODS: In a cohort of older adults (mean age 82.6 years [SD 2.6]; 58.0% female; 38.8% black), we assessed cross-sectional associations of WMH volume and COMT Val158Met (rs4680) genotype (n = 35 Met/Met, n = 180 Val carriers) with MPS by regression models adjusted for demographic and health characteristics...
January 16, 2018: Neurology
https://www.readbyqxmd.com/read/29222971/the-divergent-impact-of-catechol-o-methyltransferase-comt-val-158-met-genetic-polymorphisms-on-executive-function-in-adolescents-with-discrete-patterns-of-childhood-adversity
#19
Huihui Zhang, Jie Li, Bei Yang, Tao Ji, Zhouting Long, Qiquan Xing, Di Shao, Huayu Bai, Jiwei Sun, Fenglin Cao
PURPOSE: Catechol-O-methyltransferase (COMT) Val158 Met functional polymorphisms play a crucial role in the development of executive function (EF), but their effect may be moderated by environmental factors such as childhood adversity. The present study aimed at testing the divergent impact of the COMT Val158 Met genotype on EF in non-clinical adolescents with discrete patterns of childhood adversity. METHODS: A total of 341 participants completed the Childhood Trauma Questionnaire, the self-reported version of the Behavior Rating Inventory of Executive Function, and self-administered questionnaires on familial function...
February 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29201551/investigation-of-the-comt-val158met-variant-association-with-age-of-onset-of-psychosis-adjusting-for-cannabis-use
#20
Rohit J Lodhi, Yabing Wang, David Rossolatos, Georgina MacIntyre, Alexandra Bowker, Candice Crocker, Hongyan Ren, Aleksandra Dimitrijevic, Darren A Bugbee, Alexandra Loverock, Brett Majeau, Sudhakar Sivapalan, Virginia M Newton, Philip Tibbo, Scot E Purdon, Katherine J Aitchison
Objective: COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample. Methods: One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structured Clinical Interview for DSM-IV. Cannabis use data were collected using a self-report computerized questionnaire...
November 2017: Brain and Behavior
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