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https://www.readbyqxmd.com/read/28869277/polymorphisms-in-dopamine-associated-genes-and-cognitive-decline-in-parkinson-s-disease
#1
D Bäckström, M Eriksson Domellöf, G Granåsen, J Linder, S Mayans, E Elgh, H Zetterberg, K Blennow, L Forsgren
OBJECTIVES: Cognitive decline is common in Parkinson's disease (PD), but the underlying mechanisms for this complication are incompletely understood. Genotypes affecting dopamine transmission may be of importance. This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2-receptor availability (Catechol-O-methyltransferase [COMT] Val(158) Met genotype and DRD2 C(957) T genotype) affect the development of cognitive deficits in PD...
September 4, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28803562/dopamine-receptor-d2-drd2-dopamine-transporter-solute-carrier-family-c6-member-4-slc6a3-and-catechol-o-methyltransferase-comt-genes-as-moderators-of-the-relation-between-maternal-history-of-maltreatment-and-infant-emotion-regulation
#2
Vanessa Villani, Jaclyn Ludmer, Andrea Gonzalez, Robert Levitan, James Kennedy, Mario Masellis, Vincenzo S Basile, Christine Wekerle, Leslie Atkinson
Although infants less than 18 months old are capable of engaging in self-regulatory behavior (e.g., avoidance, withdrawal, and orienting to other aspects of their environment), the use of self-regulatory strategies at this age (as opposed to relying on caregivers) is associated with elevated behavioral and physiological distress. This study investigated infant dopamine-related genotypes (dopamine receptor D2 [DRD2], dopamine transporter solute carrier family C6, member 4 [SLC6A3], and catechol-O-methyltransferase [COMT]) as they interact with maternal self-reported history of maltreatment to predict observed infant independent emotion regulation behavior...
August 14, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28744152/pharmacodynamic-genetic-polymorphisms-affect-adverse-drug-reactions-of-haloperidol-in-patients-with-alcohol-use-disorder
#3
Mikhail Sergeevich Zastrozhin, Vadim Markovich Brodyansky, Valentin Yurievich Skryabin, Elena Anatolievna Grishina, Dmitry Vladimirovich Ivashchenko, Kristina Anatolievna Ryzhikova, Ludmila Mikhaylovna Savchenko, Alexander Olegovich Kibitov, Evgeny Alekseevich Bryun, Dmitry Alekseevich Sychev
BACKGROUND: Antipsychotic action of haloperidol is due to blockade of D2 receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D2 receptor blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these receptors and associated structures (catechol-O-methyltransferase [COMT], glycine transporter and gene encoding the density of D2 receptors on the neuronal membrane) are described. OBJECTIVE: The objectives of this study were to evaluate the correlation between DRD2, SLC6A3 (DAT) and COMT genetic polymorphisms and to investigate their effect on the development of adverse drug reactions in patients with alcohol-use disorder who received haloperidol...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/28708709/genetics-influence-neurocognitive-performance-at-baseline-but-not-concussion-history-in-collegiate-student-athletes
#4
Graham D Cochrane, Mark H Sundman, Eric E Hall, Matthew C Kostek, Kirtida Patel, Kenneth P Barnes, Caroline J Ketcham
OBJECTIVE: This study investigates 4 single-nucleotide polymorphisms [Apolipoprotein E (APOE), APOE promoter, catechol-O-methyl transferase (COMT), and dopamine D2 receptor] that have been implicated in concussion susceptibility and/or cognitive ability in collegiate student-athletes. DESIGN: Cross-sectional study. SETTING: Neuroscience laboratory at Elon University. PARTICIPANTS: Two hundred fifty division I collegiate student-athletes (66 women, 184 men) from various sports...
July 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28523234/the-effect-of-comt-val158met-and-drd2-c957t-polymorphisms-on-executive-function-and-the-impact-of-early-life-stress
#5
Kristel Klaus, Kevin Butler, Simon J Durrant, Manir Ali, Chris F Inglehearn, Timothy L Hodgson, Humberto Gutierrez, Kyla Pennington
INTRODUCTION: Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. However, increasing evidence suggests environmental factors such as early life stress may interact with genetic variants in affecting these cognitive outcomes. This study investigated the effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress in healthy adults...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28323555/influence-of-dopamine-related-genes-on-neurobehavioral-recovery-after-traumatic-brain-injury-during-early-childhood
#6
Amery Treble-Barna, Shari L Wade, Lisa J Martin, Valentina Pilipenko, Keith Owen Yeates, H Gerry Taylor, Brad G Kurowski
The present study examined the association of dopamine-related genes with short- and long-term neurobehavioral recovery, as well as neurobehavioral recovery trajectories over time, in children who had sustained early childhood traumatic brain injuries (TBI) relative to children who had sustained orthopedic injuries (OI). Participants were recruited from a prospective, longitudinal study evaluating outcomes of children who sustained a TBI (n = 68) or OI (n = 72) between the ages of 3 and 7 years. Parents completed ratings of child executive function and behavior at the immediate post-acute period (0-3 months after injury); 6, 12, and 18 months after injury; and an average of 3...
June 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27886638/preliminary-evidence-that-negative-symptom-severity-relates-to-multilocus-genetic-profile-for-dopamine-signaling-capacity-and-d2-receptor-binding-in-healthy-controls-and-in-schizophrenia
#7
Sarah A Eisenstein, Ryan Bogdan, Ling Chen, Stephen M Moerlein, Kevin J Black, Joel S Perlmutter, Tamara Hershey, Deanna M Barch
Deficits in central, subcortical dopamine (DA) signaling may underlie negative symptom severity, particularly anhedonia, in healthy individuals and in schizophrenia. To investigate these relationships, we assessed negative symptoms with the Schedule for the Assessment of Negative Symptoms and the Brief Negative Symptom Scale (BNSS) and self-reported anhedonia with the Scales for Physical and Social Anhedonia (SPSA), Temporal Experience of Pleasure Scale, and Snaith-Hamilton Pleasure Scale in 36 healthy controls (HC), 27 siblings (SIB) of individuals with schizophrenia, and 66 individuals with schizophrenia or schizoaffective disorder (SCZ)...
March 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27883923/gilles-de-la-tourette-syndrome-is-associated-with-hypermethylation-of-the-dopamine-d2-receptor-gene
#8
Kirsten R Müller-Vahl, Gesa Loeber, Alexandra Kotsiari, Linda Müller-Engling, Helge Frieling
Several lines of evidence support a "dopaminergic hypothesis" in the pathophysiology of Gilles de la Tourette syndrome (TS). The aim of this study was to investigate for the first time epigenetic changes in DNA methylation in different dopamine genes in adult patients with TS. We included 51 well characterized adult patients with TS (41 males, 10 females, mean age = 35 ± 12.6 years, range, 18-71 years) and compared results with data from a group of 51 sex- and age-matched healthy controls. Bisulfite sequencing was used to measure peripheral DNA methylation of the dopamine transporter (DAT), the dopamine D2 receptor (DRD2), and the catechol-O-methyltransferase (COMT) genes...
March 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27620551/binge-like-alcohol-exposure-during-adolescence-disrupts-dopaminergic-neurotransmission-in-the-adult-prelimbic-cortex
#9
Heather Trantham-Davidson, Samuel W Centanni, S Corrin Garr, Natasha N New, Patrick J Mulholland, Justin T Gass, Elizabeth J Glover, Stan B Floresco, Fulton T Crews, Harish R Krishnan, Subhash C Pandey, L Judson Chandler
Repeated binge-like exposure to alcohol during adolescence has been reported to perturb prefrontal cortical development, yet the mechanisms underlying these effects are unknown. Here we report that adolescent intermittent ethanol exposure induces cellular and dopaminergic abnormalities in the adult prelimbic cortex (PrL-C). Exposing rats to alcohol during early-mid adolescence (PD28-42) increased the density of long/thin dendritic spines of layer 5 pyramidal neurons in the adult PrL-C. Interestingly, although AIE exposure did not alter the expression of glutamatergic proteins in the adult PrL-C, there was a pronounced reduction in dopamine (DA) D1 receptor modulation of both intrinsic firing and evoked NMDA currents in pyramidal cells, whereas D2 receptor function was unaltered...
April 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27490263/the-association-of-dopamine-pathway-gene-score-nicotine-dependence-and-smoking-cessation-in-a-rural-male-population-of-shandong-china
#10
Suyun Li, Qiang Wang, Lulu Pan, Huijie Li, Xiaorong Yang, Fan Jiang, Nan Zhang, Mingkui Han, Chongqi Jia
BACKGROUND AND OBJECTIVES: Smoking and smoking cessation are both psychological and physiological traits. We aimed to investigate the interaction between dopamine pathway gene scores and nicotine dependence on smoking cessation in a rural Chinese male population. METHODS: Participants were recruited from 17 villages in Shandong, China. DNA was extracted from blood sample of 819 participants. 25 single nucleotide polymorphisms (SNPs) in 8 dopamine (DA) pathway genes were genotyped...
September 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/27446594/genotype-frequencies-for-polymorphisms-related-to-chemotherapy-induced-nausea-and-vomiting-in-a-japanese-population
#11
Aya Goto, Haruka Kotani, Masayuki Miyazaki, Kiyofumi Yamada, Kazuhiro Ishikawa, Yasuhiko Shimoyama, Toshimitsu Niwa, Yoshinori Hasegawa, Yukihiro Noda
BACKGROUND: Genotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects. METHODS: We analyzed 10 genotype frequencies for following polymorphisms associated with the development of CINV: serotonin 5-HT3 receptors (HTR3); neurokinin-1 receptors (Tachykinin-1 receptors, TACR1); dopamine D2 receptors (DRD2); and catechol-O-methyltransferase (COMT). RESULTS: All polymorphisms were successfully genotyped in 200 Japanese subjects and were in Hardy-Weinberg equilibrium...
2016: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/27322568/cortical-dopamine-transmission-as-measured-with-the-11c-flb-457-amphetamine-pet-imaging-paradigm-is-not-influenced-by-comt-genotype
#12
Rajesh Narendran, Divya Tumuluru, Maureen A May, Kodavali V Chowdari, Michael L Himes, Kelli Fasenmyer, W Gordon Frankle, Vishwajit L Nimgaonkar
Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex. Previous PET studies have documented the relationship between COMT Val158Met polymorphism and D1 and D2/3 receptor binding potential (BP), and interpreted them in terms of dopaminergic tone. The use of baseline dopamine D1 and D2/3 receptor binding potential (BPND) as a proxy for dopaminergic tone is problematic because they reflect both endogenous dopamine levels (a change in radiotracer's apparent affinity) and receptor density...
2016: PloS One
https://www.readbyqxmd.com/read/27241058/comt-val158met-moderation-of-dopaminergic-drug-effects-on-cognitive-function-a-critical-review
#13
REVIEW
J P Schacht
The relationship between dopamine (DA) tone in the prefrontal cortex (PFC) and PFC-dependent cognitive functions (for example, working memory, selective attention, executive function) may be described by an inverted-U-shaped function, in which both excessively high and low DA is associated with impairment. In the PFC, the COMT val158met single nucleotide polymorphism (rs4680) confers differences in catechol-O-methyltransferase (COMT) efficacy and DA tone, and individuals homozygous for the val allele display significantly reduced cortical DA...
October 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/26926580/interactive-effects-of-age-and-multi-gene-profile-on-motor-learning-and-sensorimotor-adaptation
#14
Fatemeh Noohi, Nate B Boyden, Youngbin Kwak, Jennifer Humfleet, Martijn L T M Müller, Nicolaas I Bohnen, Rachael D Seidler
The interactive association of age and dopaminergic polymorphisms on cognitive function has been studied extensively. However, there is limited research on whether age interacts with the association between genetic polymorphisms and motor learning. We examined a group of young and older adults' performance in three motor tasks: explicit sequence learning, visuomotor adaptation, and grooved pegboard. We assessed whether individuals' motor learning and performance were associated with their age and genotypes...
April 2016: Neuropsychologia
https://www.readbyqxmd.com/read/26808641/dopamine-receptor-d2-and-catechol-o-methyltransferase-gene-polymorphisms-associated-with-anorexia-nervosa-in-chinese-han-population-drd2-and-comt-gene-polymorphisms-were-associated-with-an
#15
Sufang Peng, Shunying Yu, Qian Wang, Qing Kang, Yanxia Zhang, Ran Zhang, Wenhui Jiang, Yiping Qian, Haiyin Zhang, Mingdao Zhang, Zeping Xiao, Jue Chen
Dopamine receptor D2 (DRD2) and catechol-O-methyltransferase (COMT) are important in dopamine system which is proved to be associated with food-anticipatory behavior, food restriction, reward and motivation. This has made them good candidates for anorexia nervosa (AN). The aim of this work is to explore the roles of DRD2 (rs1800497) and COMT (rs4680, rs4633, rs4818) gene polymorphisms in the susceptibility of AN within the Chinese Han population. We recruited 260AN patients with DSM-IV diagnosis criteria, and 247 unrelated, normal weight controls...
March 11, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26535948/child-maltreatment-impulsivity-and-antisocial-behavior-in-african-american-children-moderation-effects-from-a-cumulative-dopaminergic-gene-index
#16
Eric L Thibodeau, Dante Cicchetti, Fred A Rogosch
A model examining the effects of an increasing number of maltreatment subtypes experienced on antisocial behavior, as mediated by impulsivity and moderated by a polygenic index of dopaminergic genotypes, was investigated. An African American sample of children (N = 1,012, M age = 10.07) with and without maltreatment histories participated. Indicators of aggression, delinquency, and disruptive peer behavior were obtained from peer- and counselor-rated measures to form a latent variable of antisocial behavior; impulsivity was assessed by counselor report...
November 2015: Development and Psychopathology
https://www.readbyqxmd.com/read/26474929/sport-physiology-dopamine-and-nitric-oxide-some-speculations-and-hypothesis-generation
#17
J G Landers, Tobias Esch
Elite Spanish professional soccer players surprisingly showed a preponderance of an allele coding for nitric oxide synthase (NOS) that resulted in lower nitric oxide (NO) compared with Spanish endurance and power athletes and sedentary men. The present paper attempts a speculative explanation. Soccer is an "externally-paced" (EP) sport and team work dependent, requiring "executive function skills". We accept that time interval estimation skill is, in part, also an executive skill. Dopamine (DA) is prominent among the neurotransmitters with a role in such skills...
December 2015: Medical Hypotheses
https://www.readbyqxmd.com/read/26277034/mesocorticolimbic-dopamine-functioning-in-primary-psychopathy-%C3%A2-a-source-of-within-group-heterogeneity
#18
REVIEW
Bariş O Yildirim, Jan J L Derksen
Despite similar emotional deficiencies, primary psychopathic individuals can be situated on a continuum that spans from controlled to disinhibited. The constructs on which primary psychopaths are found to diverge, such as self-control, cognitive flexibility, and executive functioning, are crucially regulated by dopamine (DA). As such, the goal of this review is to examine which specific alterations in the meso-cortico-limbic DA system and corresponding genes (e.g., TH, DAT, COMT, DRD2, DRD4) might bias development towards a more controlled or disinhibited expression of primary psychopathy...
October 30, 2015: Psychiatry Research
https://www.readbyqxmd.com/read/26253211/the-comt-val-158-met-polymorphism-in-ultra-endurance-athletes
#19
Keelyn van Breda, Malcolm Collins, Dan J Stein, Laurie Rauch
UNLABELLED: Chronic levels of physical activity have been associated with increased dopamine (D2) receptors resulting in increased sensitivity to dopamine release. The catechol-O-methyltransferase enzyme, responsible for dopamine degradation, contains a functional polymorphism, which plays an important role in dopamine regulation within the prefrontal cortex. This polymorphism has previously been shown to affect human cognition and personality. However, the effect of this polymorphism has not been shown in ultra-endurance athletes...
November 1, 2015: Physiology & Behavior
https://www.readbyqxmd.com/read/26119471/functional-genetic-variation-in-dopamine-signaling-moderates-prefrontal-cortical-activity-during-risky-decision-making
#20
Milky Kohno, Erika L Nurmi, Christopher P Laughlin, Angelica M Morales, Emma H Gail, Gerhard S Hellemann, Edythe D London
Brain imaging has revealed links between prefrontal activity during risky decision-making and striatal dopamine receptors. Specifically, striatal dopamine D2-like receptor availability is correlated with risk-taking behavior and sensitivity of prefrontal activation to risk in the Balloon Analogue Risk Task (BART). The extent to which these associations, involving a single neurochemical measure, reflect more general effects of dopaminergic functioning on risky decision making, however, is unknown. Here, 65 healthy participants provided genotypes and performed the BART during functional magnetic resonance imaging...
February 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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