Caroline C Picoli, Patrícia Rocha Martins, Xiao Lin Casey Wong, Thamires Righi, Pedro P G Guimarães, Mauro C X Pinto, Jaime H Amorim, Vasco A C Azevedo, Silma Regina Pereira, Alexandre Kanashiro, Fabio Cardoso Cruz, Rodrigo R Resende, Akiva Mintz, Paul S Frenette, Alexander Birbrair
Hematopoietic stem cells are maintained in a specialized microenvironment, known as the 'niche', within the bone marrow. Understanding the contribution of cellular and molecular components within the bone marrow niche for the maintenance of hematopoietic stem cells is crucial for the success of therapeutic applications. So far, the roles of crucial mechanisms within the bone marrow niche have been explored in transgenic animals in which genetic modifications are ubiquitously introduced in the whole body. The lack of precise tools to explore genetic alterations exclusively within the bone marrow prevents our determination of whether the observed outcomes result from confounding effects from other organs...
December 31, 2022: Stem cell reviews and reports