keyword
https://read.qxmd.com/read/33722397/pain-manifestations-of-covid-19-and-their-association-with-mortality-a-multicenter-prospective-observational-study
#21
MULTICENTER STUDY
Nigel Knox, Chang-Soon Lee, Jee Youn Moon, Steven P Cohen
OBJECTIVES: To determine the prevalence and breakdown of pain symptoms among patients with coronavirus disease 2019 (COVID-19) infection admitted for nonpain symptoms and the association between the presence of pain and intensive care unit (ICU) admission and death. PATIENTS AND METHODS: In this multicenter prospective study, data on the intensity and type of pain were collected on 169 patients with active severe acute respiratory syndrome coronavirus 2 infection at 2 teaching hospitals in the United States and Korea and on 8 patients with acute pain at another large teaching hospital between February 1, 2020, and June 15, 2020...
April 2021: Mayo Clinic Proceedings
https://read.qxmd.com/read/32897461/a-randomized-comparison-of-training-programs-using-a-pelvic-model-designed-to-enhance-pelvic-floor-examination-in-patients-presenting-with-chronic-pelvic-pain
#22
JOURNAL ARTICLE
Maria Giroux, Suzanne Funk, Erwin Karreman, Huse Kamencic, Rashmi Bhargava
INTRODUCTION: Pelvic floor myalgia is a common cause and contributor to chronic pelvic pain [Neurourol Urodyn 4:984-1008 (2017)]. The purpose of this study was to compare in-person versus video-based teaching methods of a comprehensive assessment of the pelvic floor musculature on a pelvic model. METHODS: A randomized controlled trial of 46 participants was conducted. The participants were randomized into two groups. Both groups were taught by the same pelvic floor physiotherapist using two different teaching methods on a pelvic model...
September 8, 2020: International Urogynecology Journal
https://read.qxmd.com/read/32477874/glycogenin-1-deficiency-mimicking-limb-girdle-muscular-dystrophy
#23
Claire Lefeuvre, Stéphane Schaeffer, Robert-Yves Carlier, Maxime Fournier, Françoise Chapon, Valérie Biancalana, Guillaume Nicolas, Edoardo Malfatti, Pascal Laforêt
Glycogen storage disease type XV (GSD XV) is a recently described muscle glycogenosis due to glycogenin-1 ( GYG1 ) deficiency characterized by the presence of polyglucosan bodies on muscle biopsy (Polyglucosan body myopathy-2, PGBM2). Here we describe a 44 year-old man with limb-girdle muscle weakness mimicking a limb-girdle muscular dystrophy (LGMD), and early onset exertional myalgia. Neurologic examination revealed a waddling gait with hyperlordosis, bilateral asymmetric scapular winging, mild asymmetric deltoid and biceps brachii weakness, and pelvic-girdle weakness involving the gluteal muscles and, to a lesser extent, the quadriceps...
September 2020: Molecular Genetics and Metabolism Reports
https://read.qxmd.com/read/32128454/chc-for-pelvic-pain-in-women-with-endometriosis-ineffectiveness-or-discontinuation-due-to-side-effects
#24
JOURNAL ARTICLE
Paul J Yong, Najla Alsowayan, Heather Noga, Christina Williams, Catherine Allaire, Sarka Lisonkova, Mohamed A Bedaiwy
STUDY QUESTION: What are the use patterns and factors associated with combined hormonal contraception (CHC) ineffectiveness or discontinuation due to side-effects in patients with endometriosis and pelvic pain? SUMMARY ANSWER: Worse chronic pelvic pain (CPP) severity and pelvic floor myalgia were associated with continuous CHC ineffectiveness, while poorer quality-of-life was associated with continuous CHC discontinuation due to side-effects. WHAT IS KNOWN ALREADY: CHC is a first line of therapy for endometriosis-associated pelvic pain in women...
2020: Human Reproduction Open
https://read.qxmd.com/read/32014489/a-new-report-of-autoinflammation-and-plcg2-associated-antibody-deficiency-and-immune-dysregulation-aplaid-with-a-homozygous-pattern-from-iran
#25
JOURNAL ARTICLE
Alireza Khabbazi, Haniyeh Rahbar Kafshboran, Maryam Nasiri Aghdam, Jafar Nouri Nojadeh, Hossein Daghagh, Yousef Daneshmandpour, Mina Kazemzadeh, Hamid Hamzeiy, Ebrahim Sakhinia
Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation (APLAID) is an autosomal dominant autoinflammatory disease characterized by episodic skin, musculoskeletal, ophthalmic and gastrointestinal tract symptoms. Here we report an 11-year-old girl with a history of repeated episodes of fever, myalgia, arthralgia, abdominal pain, and urticarial rash in the trunk and limbs. Chest and pelvic X-Ray, sacroiliac joints MRI, brain MRI and abdominal CT scan were normal. Anti-nuclear antibody, Rheumatoid factor, cryoglobulin, ANCA/PR3, p-ANCA/MPO, anti-smooth muscle antibody and anti-mitochondrial antibody were negative...
May 2020: Immunology Letters
https://read.qxmd.com/read/31804367/secondary-lower-limbs-lymphedema-in-patients-with-chikungunya-fever
#26
JOURNAL ARTICLE
Catarina Coelho Almeida, Esdras Marques Lins, Simone Cristina Soares Brandão, Flavia Cristina Morone Pinto, José Lamartine de Andrade Aguiar, José Luiz de Lima Filho, Fernanda Appolônio Rocha
Chikungunya fever (CHIKF) is an arbovirus characterized by acute fever, myalgia and polyarthralgia. Lymphedema in the lower limbs (LL) was observed in several patients during an outbreak of CHIKF in the state of Pernambuco (Brazil) in 2016. No reports on lymphatic vessels disease due to CHIKF have been described. The aim of the study was to follow lymphatic abnormalities in the LL of 16 patients with CHIKF, using lymphoscintigraphy.An observational, prospective study with patients in the acute phase of CHIKF (confirmed serological diagnosis) with LL edema submitted to clinical evaluation and lymphoscintigraphy at baseline and after 90 days...
December 2019: Medicine (Baltimore)
https://read.qxmd.com/read/31174820/autoinflammatory-autoimmunity-syndrome-induced-by-adjuvants-shoenfeld-s-syndrome-in-patients-after-a-polypropylene-mesh-implantation
#27
REVIEW
Jan Willem Cohen Tervaert
In both hernia repair and pelvic organ prolapse surgery, polypropylene (PP) meshes are increasingly used. Although these technologies offer tremendous clinical benefits, the efficacy of these implants can be hindered by the body's immunologic reaction to the implanted material. Undesirable local effects such as chronic pain have been extensively described. Systemic effects, however, are not yet reported. Because systemic effects after implantation of other biomaterials have been described, we evaluated patients with implanted PP meshes for signs and symptoms of biomaterial-related systemic illnesses...
August 2018: Best Practice & Research. Clinical Rheumatology
https://read.qxmd.com/read/31010782/vaginal-diazepam-for-nonrelaxing-pelvic-floor-dysfunction-the-pharmacokinetic-profile
#28
JOURNAL ARTICLE
Alyssa M Larish, Rozalin R Dickson, Rachel A Kudgus, Renee M McGovern, Joel M Reid, W Michael Hooten, Wayne T Nicholson, Lisa E Vaughan, Tatnai L Burnett, Shannon K Laughlin-Tommaso, Stephanie S Faubion, Isabel C Green
BACKGROUND: Vaginal diazepam is frequently used to treat pelvic floor tension myalgia and pelvic pain despite limited knowledge of systemic absorption. AIM: To determine the pharmacokinetic and adverse event profile of diazepam vaginal suppositories. METHODS: We used a prospective pharmacokinetic design with repeated assessments of diazepam levels. Eight healthy volunteers were administered a 10-mg compounded vaginal diazepam suppository in the outpatient gynecologic clinic...
June 2019: Journal of Sexual Medicine
https://read.qxmd.com/read/30981616/streptococcal-toxic-shock-syndrome-after-insertion-of-a-levonorgestrel-intrauterine-device
#29
JOURNAL ARTICLE
Jacques Balayla, Yaron Gil, James Mattina, Eman Al-Shehri, Cleve Ziegler
BACKGROUND: The insertion of intrauterine devices (IUDs) is associated with a small increased risk of pelvic inflammatory disease and ascending infection, particularly in patients with risk factors. However, the risk of sepsis and toxic shock syndrome after insertion of an IUD is a rare event, described only through case reports in the literature. CASE: This report describes the case of a 40-year-old woman who presented with high fever, myalgias, and abdominal pain 2 days following the insertion of a levonorgestrel-releasing IUD...
April 10, 2019: Journal of Obstetrics and Gynaecology Canada: JOGC
https://read.qxmd.com/read/30588074/chronic-pain-clinic-efficiency-analysis-optimization-through-use-of-the-gantt-diagram-and-visit-diagnoses
#30
JOURNAL ARTICLE
Hayden E Hundley, Mark E Hudson, Ajay D Wasan, Trent D Emerick
Objective: The aim of this study is to identify scheduling inefficiencies and to develop a personalized schedule based on diagnosis, service time (face-to-face time between the patient and the provider), and patient wait time using a Gantt diagram in a chronic pain clinic. Design: This is an observational prospective cohort quality improvement (QI) study. Setting: This study was carried out at a single outpatient multidisciplinary pain management clinic in a university teaching hospital...
2019: Journal of Pain Research
https://read.qxmd.com/read/29642533/rhabdomyolysis-in-a-young-girl-with-van-wyk-grumbach-syndrome-due-to-severe-hashimoto-thyroiditis
#31
Alberto Leonardi, Laura Penta, Marta Cofini, Lucia Lanciotti, Nicola Principi, Susanna Esposito
Background: Autoimmune hypothyroidism (Hashimoto thyroiditis; HT) is the most common postnatal thyroid disease. Clinical manifestations of HT vary according to disease severity. Due to the pleiotropic effects of thyroid hormone, less common signs and symptoms of HT can occur, leading to a delay in diagnosis. Case presentation: A 9-year-old girl of Indian origin was admitted for a one-week history of widespread myalgia, fatigue, muscle weakness, difficulty walking, and a significant increase in weight (approximately 2 kg) without any changes in daily habits...
April 9, 2018: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/29031895/chronic-pelvic-pain-in-an-interdisciplinary-setting-1-year-prospective%C3%A2-cohort
#32
JOURNAL ARTICLE
Catherine Allaire, Christina Williams, Sonja Bodmer-Roy, Sean Zhu, Kristina Arion, Kristin Ambacher, Jessica Wu, Ali Yosef, Fontayne Wong, Heather Noga, Susannah Britnell, Holly Yager, Mohamed A Bedaiwy, Arianne Y Albert, Sarka Lisonkova, Paul J Yong
BACKGROUND: Chronic pelvic pain affects ∼15% of women, and presents a challenging problem for gynecologists due to its complex etiology involving multiple comorbidities. Thus, an interdisciplinary approach has been proposed for chronic pelvic pain, where these multifactorial comorbidities can be addressed by different interventions at a single integrated center. Moreover, while cross-sectional studies can provide some insight into the association between these comorbidities and chronic pelvic pain severity, prospective longitudinal cohorts can identify comorbidities associated with changes in chronic pelvic pain severity over time...
January 2018: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/28881388/autosomal-dominant-calpainopathy-due-to-heterozygous-capn3-c-643_663del21
#33
JOURNAL ARTICLE
Jennifer M Martinez-Thompson, Zhiyv Niu, Jennifer A Tracy, Steven A Moore, Andrea Swenson, Eric D Wieben, Margherita Milone
INTRODUCTION: A calpain-3 (CAPN3) gene heterozygous deletion (c.643_663del21) was recently linked to autosomal dominant (AD) limb-girdle muscular dystrophy. However, the possibility of digenic disease was raised. We describe 3 families with AD calpainopathy carrying this isolated mutation. METHODS: Probands heterozygous for CAPN3 c.643_663del21 were identified by targeted next generation or whole exome sequencing. Clinical findings were collected for probands and families...
April 2018: Muscle & Nerve
https://read.qxmd.com/read/28502713/an-autopsy-case-of-fatal-acute-peritonitis-complicated-by-illegal-acupuncture-therapy
#34
JOURNAL ARTICLE
DongJa Kim, SangHan Lee
Acupuncture is an alternative medical therapy and widely practiced in Northeast Asia. Although it is known as a safe procedure, complications including infection, pneumothorax, hemorrhage, and cardiac tamponade have been reported. The authors present a rare case of fatal acute peritonitis due to penetration of acupuncture needles directly into the abdominal and pelvic cavity. The victim was a 55-year-old woman who had a recent history of chemo-radiotherapy due to breast cancer. She was collapsed three days after receiving acupuncture...
July 2017: Forensic Science International
https://read.qxmd.com/read/28488622/family-with-ehlers-danlos-syndrome-combined-classic-and-vascular-type-with-rare-presentation-of-progressive-myopathy-and-unusual-association-of-severe-facial-and-trigeminal-motor-weakness
#35
A Nalini, N Devaraddi, N Gayathri, Chandrajit Prasad, V Preethish-Kumar, K Polavarapu, S Shantanu
We report the clinical, radiological, biochemical, muscle histology, and electron microscopic features of two members of a family with combined Ehlers-Danlos syndrome (EDS) [classic and vascular type] and progressive myopathy as the primary manifestation. A 35-year old lady presented with severe gluteal and thigh muscle pain and easy fatigability for 5 years. She developed weakness and wasting of pelvic and pectoral girdles and thighs for 3 years and severe neck flexor and truncal weakness for 6 months. She had a history of recurrent jaw dislocation, easy bruising with hyperpigmentation, hyperextensibility of joints, translucent skin, and papyraceous scars...
May 2017: Neurology India
https://read.qxmd.com/read/28381078/sexual-pain-in-women-quality-of-sex-life-and-marital-relations
#36
REVIEW
Anna Ghizzani, Cinzia Orlandini, Maria G Bernardi, Gabriele Cevenini, Stefano Luisi
Common gynecological and dermatological conditions resulting in sexual pain are often observed in gynecological practice and are easily diagnosed with visual observation and laboratory tests. The lower genital tract diseases we are referring to are vaginitis, vaginoses, dermatoses, hypoestrogenism and endometriosis. All of them affect the vaginal mucosa with diverse mechanisms, their effects lasting for only few days or many months. Furthermore, they change the women's sense of wellbeing sometimes significantly and for a long period...
August 2017: Minerva Ginecologica
https://read.qxmd.com/read/27403751/persistent-postoperative-pain-pathophysiology-risk-factors-and-prevention
#37
REVIEW
Charles W Butrick
OBJECTIVE: Persistent postoperative pain (PPOP) is the second most common reason for a patient to seek care at a chronic pain center. Many of the patients seen with prolapse or incontinence are at risk for developing PPOP as a result of the surgeries done for these problems. The pathophysiology of this disabling pain disorder is well understood, and the risk factors are easy to identify. Once identified, perioperative interventions can be offered to attempt to prevent PPOP. METHODS AND RESULTS: Evaluation of articles obtained using a MEDLINE search involving chronic pain and PPOP, including prevalence, pathophysiology, and prevention was reviewed...
September 2016: Female Pelvic Medicine & Reconstructive Surgery
https://read.qxmd.com/read/25935914/primary-mediastinal-thymic-b-cell-lymphoma-presenting-as-cutaneous-vasculitis
#38
JOURNAL ARTICLE
Adriana De Sousa Lages, Helder Esperto, Lèlita Santos, Armando Carvalho
Cutaneous small vessel vasculitis is a severe neutrophilic vascular inflammation mediated by immune complexes that involves the dermal postcapillary venules. Neoplasms represent 2-5% of all causes of secondary cutaneous vasculitis. We present a case of a 52-year-old man who was admitted due to a 10-day history of respiratory symptoms and myalgia. From the third day of symptoms onwards, the patient noticed the appearance of cutaneous lesions in the lower limbs with palpable purpura and erythematous papules. Additionally, he reported of asthenia, anorexia and weight loss during the prior month...
May 2, 2015: BMJ Case Reports
https://read.qxmd.com/read/25660431/-menstruation-inflammation-and-comorbidities-implications-for-woman-health
#39
REVIEW
A Graziottin, P P Zanello
Menstruation is the genital sign of systemic endocrine events. Heterogeneity of perimenstrual symptoms is associated with levels of inflammation, triggered by the fall of estrogens at genital and systemic level. Aim of the review is to concisely analyze the evidence on: 1) genital and systemic endocrine and inflammatory events associated with periods and perimenstrual symptoms; 2) rationale of intervention to reduce their intensity and impact on women's lives. This review of the literature, selected with a clinical perspective, supports the inflammatory basis of the menstrual event, triggered by the estrogens' and progesterone' fall...
February 2015: Minerva Ginecologica
https://read.qxmd.com/read/25527482/a-pilot-randomized-trial-of-levator-injections-versus-physical-therapy-for-treatment-of-pelvic-floor-myalgia-and-sexual-pain
#40
RANDOMIZED CONTROLLED TRIAL
Dani Zoorob, Mary South, Mickey Karram, Julie Sroga, Rose Maxwell, Aparna Shah, James Whiteside
INTRODUCTION AND HYPOTHESIS: Our aim was to determine the effects of pelvic floor physical therapy (PT) and levator-directed trigger-point injections (LTPI) on sexual function and levator-related pelvic pain. STUDY DESIGN: A randomized trial among women with pelvic floor myalgia (PFM) was performed wherein participants received either PT or LTPI. Pain was assessed and 1 month posttreatment completion. Levator-based pain was assessed using a numeric rating scale (NRS) and the Patient Global Impression of Improvement (PGI-I) scale...
June 2015: International Urogynecology Journal
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