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dual energy bone metastasis

P Ferreira Poloni, H De Luca Vespoli, B de Sousa Almeida-Filho, F Bueloni-Dias, J Nahas-Neto, E Aguiar Petri Nahas
OBJECTIVE: To evaluate risk factors for low bone mineral density (BMD) in postmenopausal breast cancer survivors compared with postmenopausal women without breast cancer (controls). METHOD: In this study, 112 breast cancer survivors were compared to 224 women (controls). Inclusion criteria were amenorrhea ≥12 months, age 45-75 years, treated for breast cancer, and metastasis-free for at least 5 years. The control group consisted of women without breast cancer, matched by age and menopause status (in a proportion of 1: 2 as sample calculation)...
June 1, 2017: Climacteric: the Journal of the International Menopause Society
Pianpian Fan, Qin Wang, Chunyan Lu, Decai Chen
Generalized high bone mineral density (BMD) on Dual-energy X-ray absorptiometry (DXA) scanning most commonly reflects metabolic bone disease. However, some malignancies could also stimulate the underlying processes. We reported that a 41-year-old female was referred for lumbago. She did not complain of any symptoms in the digestive system. DXA revealed high BMD in the lumbar vertebras. Marked increase in bone mass was observed in an X-ray of chest compared with one conducted 6 months previously. Additionally, an X-ray of the axial skeleton showed diffuse sclerotic change...
March 2017: Postgraduate Medicine
Seung Hyun Lee, Young Han Lee, Seok Hahn, Jin-Suck Suh
PURPOSE: This study aims to compare fat fraction of lumbar vertebrae between cancer and non-cancer patients, using the two-point modified Dixon (mDixon) turbo spin-echo (TSE) MRI with flexible echo times and multipeak fat spectral model. MATERIALS AND METHODS: Fat fraction was calculated from fat and water images reconstructed by the mDixon TSE technique. Fat fraction of fat-water phantoms measured with the mDixon TSE method was compared with actual fat percentages...
October 2016: Magnetic Resonance Imaging
Yubin Lee, Ari Kim, Heung Yeol Kim, Wan Kyu Eo, Eun Sil Lee, Sungwook Chun
OBJECTIVE: To evaluate the bone mineral density (BMD) in the lumbar spine and femur in postmenopausal women with cervical cancer and endometrial cancer without bone metastasis in comparison with that in healthy control postmenopausal women, and to assess the loss of BMD according to the cancer stage. MATERIALS AND METHODS: We analyzed the BMD of the lumbar spine and femur using dual-energy X-ray absorptiometry (DXA) in 218 patients with cervical cancer, 85 patients with endometrial cancer, and 259 healthy controls...
2015: Journal of Cancer
Young Lim Oh, Man Soo Yoon, Dong Soo Suh, Ari Kim, Min Joung Kim, Ji Young Lee, Yong Jung Song, Yong Il Ji, Ki Hyung Kim, Sungwook Chun
OBJECTIVE: This study aimed to evaluate the impact of cancer treatment on bone mineral density (BMD) in the lumbar spine (LS) and femur in the postmenopausal women with cervical or endometrial cancer without bone metastasis compared to normal control postmenopausal women. METHODS: We retrospectively evaluated the BMD data in the LS, femur neck (FN) and trochanter (FT) by dual-energy X-ray absorptiometry and laboratory data of bone turnover markers at baseline and after one year in 130 patients with cervical cancer, 68 patients with endometrial cancer, and 225 healthy controls...
2015: Journal of Cancer
Young Han Lee, Sungjun Kim, Daekeon Lim, Jin-Suck Suh, Ho-Taek Song
BACKGROUND: Dual-energy computed tomography (DECT) images may be underutilized for the evaluation of skeletal metastasis. Spectral parametric segmentation of DECT can produce bone-iodine separated images, which have the potential to detect bone metastases. PURPOSE: To evaluate the potential of bone-iodine separation in the detection of bone metastasis with spectral parametric segmentation of DECT images which are acquired at clinical follow-up for patients with prior malignancy...
April 2015: Acta Radiologica
S Chun, Y I Ji
Objective To compare the bone mineral density (BMD) of the lumbar spine and femur in postmenopausal women with cervical and endometrial cancer without bone metastasis with that in normal control postmenopausal women Methods We retrospectively analyzed the BMD of the lumbar spine and femur using dual-energy X-ray absorptiometry in 130 patients with cervical cancer, 68 patients with endometrial cancer, and 225 healthy controls. Results The serum levels of calcium, phosphorus, osteocalcin, total alkaline phosphatase and urine deoxypyridinoline were measured in all participants...
December 5, 2013: Climacteric: the Journal of the International Menopause Society
Keo Tabane, Daniel A Vorobiof
Bisphosphonates have emerged as an important tool in the supportive care of women with early breast cancer. Whereas traditionally, these drugs have been part of the treatment of osseous metastasis, the key role of bisphosphonates in preserving bone health in patients with early breast cancer cannot be overemphasised. Currently the most established use of bisphosphonates in early breast cancer patients is in women receiving hormonal blockade, mostly aromatase inhibitors (AI), with concomitant osteopenia. To that end, it is recommended that every woman undergo a Dual Energy X-Ray absorptiometry (DEXA) scan before commencement of an AI and annually during the treatment duration...
December 2011: Current Treatment Options in Oncology
Chi-hang Yee, Chi-fai Ng, Annie Y F Wong, Chi-kowk Chan, See-ming Hou, Sidney K H Yip
AIM: To explore the bone mineral density (BMD) preservation effect of zoledronic acid and its renal safety and tolerability in Chinese patients with prostate cancer on androgen deprivation therapy (ADT). METHODS: Overall 26 prostate cancer patients with ADT were given zoledronic acid 4 mg by a 15-min i.v. infusion every 3 months for up to 12 months. Assessment was made at baseline and at 3, 6, 9 and 12 months. Dual-energy X-ray absorptiometry was used to measure the BMD of the lumbar spine and the femoral neck at baseline and 12 months...
June 2011: Asia-Pacific Journal of Clinical Oncology
A Janane, F Hajji, T Ismail, C Jawad, J Crepin-Elondo, M Ghadouane, A Ameur, M Abbar, A Albouzidi
AIM: To evaluate total body bone mineral density and regional bone mineral density in patients with prostate cancer with and without metastases, and to correlate them with bone scintigraphy findings. PATIENTS AND METHODS: 135 patients with prostatic carcinoma and 50 healthy subjects were investigated with bone scintigraphy and dual-energy X-ray absorptiometry. The bone scintigraphic findings were classified as normal (score 0: n=55), abnormal but not typical for metastases (score 1: n=45), and typical pattern of metastases (score 2: n=35)...
July 2011: Actas Urologicas Españolas
Youssef A Al-Tonbary, Magdy A El-Ziny, Ashraf A Elsharkawy, Amany K El-Hawary, Rasha El-Ashry, Ashraf E Fouda
BACKGROUND: Neuroblastoma is the second most common extracranial malignant tumor of childhood and the most common solid tumor of infancy which is characterized by bone metastasis. Previous reports on bone mineral density (BMD) in patients with leukemia and solid malignancies concentrate on long-term survivors and on the effect of chemotherapeutic agents and irradiation. Also, evaluation of BMD in neuroblastoma was reported in few studies which were conducted upon adult survivors of childhood cancer...
February 2011: Pediatric Blood & Cancer
Takeshi Yuasa, Shinya Maita, Norihiko Tsuchiya, Zhiyong Ma, Shintaro Narita, Yohei Horikawa, Shinya Yamamoto, Junji Yonese, Iwao Fukui, Shunji Takahashi, Kiyohiko Hatake, Tomonori Habuchi
OBJECTIVES: To examine Japanese patients who had received androgen-deprivation therapy (ADT) for longer periods, as it is known that ADT of patients with prostate cancer reduces their bone mineral density (BMD). However, our previous cross-sectional study revealed that short-term ADT (average, 23.5 months) does not significantly increase the prevalence of osteoporosis in Japanese patients. METHODS: The subjects consisted of 201 native Japanese patients with prostate cancer...
May 2010: Urology
Payam S Pahlavan, William D Leslie
SAPHO syndrome is an acronym for a clinical entity characterized by synovitis, acne, palmoplantar pustulosis, hyperostosis, and osteitis. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome, even though not all components always coexist. We report a case of a 62-year-old female presenting with a lytic manubrial lesion. Diagnoses of metastasis or infection were initially entertained but excluded on open biopsy, and SAPHO syndrome was confirmed on additional investigation and follow-up...
December 2008: Clinical Nuclear Medicine
Hakki Perk, Mustafa Yildiz, Alim Kosar, Sureyya Cerci, Feray Soyupek, Alper Ozorak, Cem Dilmen
OBJECTIVE: Bone metastasis is a major cause of morbidity in prostatic cancer. Therefore, detecting and monitoring bone lesions are crucial for treatment of prostatic carcinoma. We aimed to evaluate total body bone mineral density and regional bone mineral density in patients with prostate cancer with and without metastases, and to compare them with bone scintigraphy. METHODS: Fifty-four patients with prostatic carcinoma and 20 healthy subjects were investigated with bone scintigraphy and dual-energy X-ray absorptiometry...
May 2008: Urologic Oncology
N A Shkumat, J H Siewerdsen, S Richard, N S Paul, J Yorkston, R Van Metter
Experiments were conducted to determine optimal acquisition techniques for bone image decompositions for a prototype dual-energy (DE) imaging system. Technique parameters included kVp pair (denoted [kVp(L)/kVp(H)]) and dose allocation (the proportion of dose in low- and high-energy projections), each optimized to provide maximum signal difference-to-noise ratio in DE images. Experiments involved a chest phantom representing an average patient size and containing simulated ribs and lung nodules. Low- and high-energy kVp were varied from 60-90 and 120-150 kVp, respectively...
February 2008: Medical Physics
Dimitrios A Linos
The management of adrenalomas should include the following: 1. A detailed history and physical examination to detect subtle evidence of hormonal hypersecretion or the possibility of metastatic carcinoma. 2. Hormonal studies: Short dexamethasone suppression test (2 mg of dexamethasone) followed by a high-dose dexamethasone suppression test (8 mg), CRH assay and analysis of the diurnal cortisol rhythm if serum cortisol value post dexamethasone is greater than 3 microg/dL, 24-hour (or spot) urinary catecholamine metabolites (metanephrine and normetanephrine), In the hypertensive or normotensive patient with serum potassium less than 3...
January 2003: Hormones: International Journal of Endocrinology and Metabolism
Tawee Tanvetyanon
BACKGROUND: Androgen deprivation therapy (ADT) is a strong risk factor for osteoporosis. The current study identified physician practices in preventing or treating osteoporosis during ADT. The practices of interest are the uses of dual-energy X-ray absorptiometry (DXA) scans, bisphosphonates, calcium or vitamin D supplement, calcitonin, or estrogen. METHODS: A retrospective medical record review was conducted. Patients were included if they had received ADT with goserelin injection for >/= 1 year...
January 15, 2005: Cancer
M Ozgür Tan, Cenk Yilmaz, M Cemil Uygur, Burcu Duyur, Demokan Erol
OBJECTIVE: To investigate whether combined androgen blockade (CAB) produces any adverse effects on bone metabolism and mineral density in patients with locally advanced prostate cancer. MATERIALS AND METHODS: The study group consisted of 17 stage T4 prostate cancer patients treated with CAB and had no evidence of bone metastasis on bone scintigraphy. The mean duration of CAB and final total prostate specific antigen (PSA) level at the time of study were found at 28...
2002: International Urology and Nephrology
Yao-Ching Hung, Lian-Shung Yeh, Wei-Chun Chang, Cheng-Chieh Lin, Chia-Hung Kao
BACKGROUND: In women, osteoporosis is a common chronic disease that induces spinal compression and femoral neck fractures, resulting in life-threatening complications. It is very important to identify risk factors in order to prevent this disorder. Bone destruction is a well-recognized complication in a variety of neoplasms without bone metastasis. Therefore, in the present study, we investigated the spinal bone mineral density (BMD) in patients with cervical cancer without bone metastases...
October 2002: Japanese Journal of Clinical Oncology
C L Shapiro, J Keating, J E Angell, M Janicek, R Gelman, D Hayes, M S LeBoff
Response to systemic therapy in breast cancer patients with lytic skeletal metastases manifests as a shift from increased bone resorption to new bone formation. We hypothesized that dual-energy x-ray absorptiometry (DXA) could be used to prospectively quantitate changes in bone mineral density (BMD) in metastatic skeletal lesions in breast cancer patients receiving systemic therapy. Nine metastatic breast cancer patients with one or more assessable lytic skeletal metastases receiving systemic therapy were prospectively evaluated with DXA, skeletal radiographs, computed tomography (CT), and radionuclide bone scans at baseline (t = 0 months, 2 months, and 6 months)...
1999: Cancer Investigation
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