Carolina Maldonado-Díaz, Satomi Hiya, Raquel T Yokoda, Kurt Farrell, Gabriel A Marx, Justin Kauffman, Elena V Daoud, Mitzi M Gonzales, Alicia S Parker, Leyla Canbeldek, Lakshmi Shree Kulumani Mahadevan, John F Crary, Charles L White, Jamie M Walker, Timothy E Richardson
Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), and cerebrovascular disease (CVD) frequently coexist, but little is known about the exact contribution of each pathology to cognitive decline and dementia in subjects with mixed pathologies. We explored the relative cognitive impact of concurrent common and rare neurodegenerative pathologies employing multivariate logistic regression analysis adjusted for age, gender, and level of education...
March 23, 2024: Acta Neuropathologica