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Conjugated linoleic acid

Robert Ringseis, Wilhelm Windisch, Klaus Eder
In the present study, transcript profiling was carried out in liver biopsies from high-yielding dairy cows at week 5 of lactation in order to identify genes and pathways regulated by feeding rumen-protected conjugated linoleic acid (CLA) during the transition period. Analysis of a bovine whole genome microarray revealed a total number of 130 annotated differentially expressed genes (DEGs) in the liver between cows of the CLA group and the control group (filter: P < 0.05 and fold change (FC) ≥ 1.3 or ≤- 1...
December 2016: Genomics Data
Yoo Kim, Daeyoung Kim, Yeonhwa Park
Previously, it was reported that conjugated linoleic acid (CLA) with exercise training potentially improved endurance capacity via the peroxisome proliferator-activated receptor δ (PPARδ)-mediated mechanism in mice. This study determined the role of exercise and/or CLA in endurance capacity and PPARδ-associated regulators. Male 129Sv/J mice were fed either control (soybean oil) or CLA (0.5%) containing diets for 4 weeks and were further divided into sedentary or training regimes. CLA supplementation significantly reduced body weight and fat mass independent of exercise during the experimental period...
September 7, 2016: Journal of Nutritional Biochemistry
Tom F O'Callaghan, Deirdre Hennessy, Stephen McAuliffe, Kieran N Kilcawley, Michael O'Donovan, Pat Dillon, R Paul Ross, Catherine Stanton
The aim of this study was to investigate the effects of different feeding systems on milk quality and composition. Fifty-four multiparous and primiparous Friesian lactating cows were divided into 3 groups (n = 18) to study the effects of 3 feeding systems over a full lactation. Group 1 was housed indoors and offered a total mixed ration diet (TMR), group 2 was maintained outdoors on a perennial ryegrass pasture (referred to as grass), and group 3 was also grazed outdoors on a perennial ryegrass/white clover pasture (referred to as clover)...
October 5, 2016: Journal of Dairy Science
L Della Casa, E Rossi, C Romanelli, L Gibellini, A Iannone
BACKGROUND: The individual genetic variations, as a response to diet, have recently caught the attention of several researchers. In addition, there is also a trend to assume food containing beneficial substances, or to supplement food with specific compounds. Among these, there is the conjugated linoleic acid (CLA), which has been demonstrated to reduce fat mass and to increase lean mass, even though its mechanism of action is still not known. We investigated the effect of CLA isomers (CLA c9,t11 and CLA t10,c12) on the proteomic profile of liver, adipose tissue, and muscle of mouse, with the aim of verifying the presence of a modification in fat and lean mass, and to explore the mechanism of action...
2016: Genes & Nutrition
Ilsa C Barbosa, Maria E G Oliveira, Marta S Madruga, Beatriz Gullón, Maria T B Pacheco, Ana M P Gomes, Ana S M Batista, Maria M E Pintado, Evandro L Souza, Rita C R E Queiroga
The effects of the addition of Lactobacillus acidophilus LA-05, Bifidobacterium animalis subsp. lactis BB-12 and inulin on the quality characteristics of creamy goat cheese during refrigerated storage were evaluated. The manufactured cheeses included the addition of starter culture (Lactococcus lactis subsp. lactis and Lactococcus lactis subsp. cremoris - R-704) (CC); starter culture, L. acidophilus LA-05 and inulin (CLA); starter culture, B. lactis BB-12 and inulin (CBB); or starter culture, L. acidophilus LA-05, B...
October 12, 2016: Food & Function
X Z Li, S H Choi, C G Yan, J S Shin, S B Smith
Supplementary dietary plant oils have the potential to alter milk fatty acid composition in ruminants as a result of changes in the amount and kind of fatty acid precursors. We hypothesized that linseed oil in combination with malate (a key propionate precursor in the rumen) would increase ∆9 unsaturated fatty acids and specific gene expression in somatic cells and mammary glands of lactating goats. Twelve lactating goats were used in a 3 × 3 Latin square design. Treatments included the basal diet (CON), the CON plus 4% linseed oil (LO), and the CON plus 4% linseed oil and 2% -malate (LOM)...
August 2016: Journal of Animal Science
Patrícia Aparecida Vieira de Barros, Simone de Vasconcelos Generoso, Maria Emília Rabelo Andrade, Marco Antonio Sundfeld da Gama, Fernando Cesar Ferraz Lopes, Éricka Lorenna de Sales E Souza, Flaviano Dos Santos Martins, Sued Eustáquio Mendes Miranda, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso
Mucositis is the most common side effect due to chemotherapy or radiotherapy. It refers to the inflammation of intestinal mucous membranes, and it is associated with complications such as diarrhea, weight loss, and increased intestinal permeability (IP). This study was designed to evaluate the effect of diet containing conjugated linoleic acid (CLA)-enriched butter on intestinal damage and inflammatory response after 24 h of 5-fluorouracil (5-FU)-induced mucositis. Mice were divided into four groups: CTL; CLA; 5-FU, and CLA 5-FU, and they were fed for 31 days...
September 28, 2016: Nutrition and Cancer
M Mele, N P P Macciotta, A Cecchinato, G Conte, S Schiavon, G Bittante
We investigated the potential of using multivariate factor analysis to extract metabolic information from data on the quantity and quality of milk produced under different management systems. We collected data from individual milk samples taken from 1,158 Brown Swiss cows farmed in 85 traditional or modern herds in Trento Province (Italy). Factor analysis was carried out on 47 individual fatty acids, milk yield, and 5 compositional milk traits (fat, protein, casein, and lactose contents, somatic cell score)...
September 21, 2016: Journal of Dairy Science
Melissa L Bainbridge, Emily Egolf, John W Barlow, Juan P Alvez, Joe Roman, Jana Kraft
The demand for dairy products from grass-fed cows is driven, in part, by their more desirable fatty acid (FA) profile, containing more n-3 FA and conjugated linoleic acids (CLA) than conventionally produced dairy products. This study investigated the effects of pearl millet (PM) vs. cool-season pasture (CSP) on animal performance and milk FA in a grazing system. Eight Holstein dairy cows were used in a repeated measures design with four-week periods. Forage type had no effect on animal performance (estimated dry matter intake, milk production, fat, or protein)...
February 15, 2017: Food Chemistry
Rosa M Pérez-Serrano, M Laura González-Dávalos, Carlos Lozano-Flores, Armando Shimada, Anaid Antaramian, Alfredo Varela-Echavarría, Ofelia Mora
PURPOSE: The aim of this work was to evaluate the effect of PPAR agonists on the differentiation and metabolic features of porcine mesenchymal stem cells induced to the adipogenic or myogenic lineages. METHODS: Bone marrow MSCs from neonate pigs were isolated and identified by cell proliferation, cell surface markers or the gene expression of stem cells (CD44, CD90, CD105 or Oct4 and Nanog, respectively). Cells were differentiated into adipose or muscle cells and treated with the PPAR agonists; adipogenic and myogenic differentiation was promoted by adding these compounds...
September 20, 2016: Cells, Tissues, Organs
Gitane Fuke, José Laerte Nornberg
The term CLA (conjugated linoleic acid) corresponds to a mixture of positional and geometric isomers of linoleic acid. Two of these isomers (9c, 11t and 10t, 12c) have biological activity. The milk and dairy products are the most abundant source of conjugated linoleic acid, which refers to a group of positional and geometric isomers of CLA (CLA 18:2 cis-9, cis-12). The following research aims to approach aspects regarding the CLA, as well as its relationship with diseases. Conjugated linoleic acids have been studied for their beneficial effects in the prevention and treatment of many diseases, including obesity, cancer, diabetes, and cardiovascular diseases...
January 2, 2017: Critical Reviews in Food Science and Nutrition
Roya Kolahdouz Mohammadi, Minoo Bagheri, Mina Kolahdouz Mohammadi, Farzad Shidfar
INTRODUCTION: R-TFA (ruminant trans-fatty acids) especially cis9, trans11-conjugated linoleic acid (c9,t11-CLA) and trans11-18:1 vaccenic acid (t11-18:1 VA) appear to have anticarcinogenic activity against breast cancer in animal and in vitro experiments. However, the results remain inconsistent. We therefore conducted a systematic review and meta- analysis to assess the association of c9,t11-CLA, and t11-18:1 VA (intake or serum levels) with breast cancer risk. EVIDENCE ACQUISITION: Relevant studies were identified by a search of PubMed, OVID, SCOPUS and Google scholar databases through 25 May 2015...
September 14, 2016: Minerva Endocrinologica
Silvia Arboleya, Claire Watkins, Catherine Stanton, R Paul Ross
The intestinal microbiota has increasingly been shown to have a vital role in various aspects of human health. Indeed, several studies have linked alterations in the gut microbiota with the development of different diseases. Among the vast gut bacterial community, Bifidobacterium is a genus which dominates the intestine of healthy breast-fed infants whereas in adulthood the levels are lower but relatively stable. The presence of different species of bifidobacteria changes with age, from childhood to old age...
2016: Frontiers in Microbiology
Mehrangiz Ebrahimi-Mameghani, Haleh Jamali, Reza Mahdavi, Farzad Kakaei, Rana Abedi, Bita Kabir-Mamdooh
AIM: To investigate if conjugated linoleic acid supplementation (CLA) affects metabolic factors and oxidative stress in non-alcoholic fatty liver disease (NAFLD). METHODS: The study was a randomized, controlled clinical trial conducted in specialized and subspecialized clinics of Tabriz University of Medical Sciences from January 2014 to March 2015. 38 obese NAFLD patients were randomly allocated into either the intervention group, receiving three 1000 mg softgel of CLA with a weight loss diet and 400 IU vitamin E, or into the control group, receiving only weight loss diet and 400 IU vitamin E for eight weeks...
August 31, 2016: Croatian Medical Journal
Qin Guo, Feng Wang, Fan He, Yi-Ming Ha, Qing-Peng Li, Jing Jin, Zhao-Xuan Deng
The effects of technical cashew nut shell liquid (TCNSL) on the trans isomerization of edible oils during heating are investigated. Edible oils were subjected to thermal treatment at various heating times and temperatures. Our results show that the addition of TCNSL to edible oils at the appropriate concentration during heating suppresses trans fatty acid formation and induces formation of conjugated linoleic acid (CLA) isomers. A concentration of 0.2 % TCNSL demonstrates the best ability to inhibit formation of trans-oleic acid, trans-linoleic acid, and trans-linolenic acid isomers as well as increase the formation of 9 t,11 t-CLA and 10 t,12 t-CLA isomers...
March 2016: Journal of Food Science and Technology
S Schiavon, G Cesaro, A Cecchinato, C Cipolat-Gotet, F Tagliapietra, G Bittante
The aim of this study was to investigate the consequences of reducing the dietary crude protein content, with or without a supply of protected conjugated linoleic acid (CLA), on the milk fatty acid (FA) yield and recovery in 90 d ripened cheese. Twenty mid-lactation Friesian dairy cows were reared for 4 periods of 3 wk each in groups of 5, following a 4 × 4 Latin square design. Cows were fed 4 different rations, consisting of a combination of the 2 dietary crude protein levels [150 (CP15) or 123 (CP12) g of crude protein/kg of dry matter], with or without a conjugated linoleic acid supply (80 g/d, providing 5...
August 24, 2016: Journal of Dairy Science
Nathaniel D M Jenkins, Terry J Housh, Amelia A Miramonti, Brianna D McKay, Noelle M Yeo, Cory M Smith, Ethan C Hill, Kristen C Cochrane, Joel T Cramer
The purpose of this study was to investigate the effects of 8weeks at 6g per day of RAR CLA versus placebo on cognitive function and handgrip performance in older men and women. Sixty-five (43 women, 22 men) participants (mean±SD; age=72.4±5.9yrs; BMI=26.6±4.2kg·m(-2)) were randomly assigned to a RAR CLA (n=30: 10 men, 20 women) or placebo (PLA; high oleic sunflower oil; n=35: 12 men, 23 women) group in double-blind fashion and consumed 6g·d(-1) of their allocated supplement for 8weeks. Before (Visit 1) and after supplementation (Visit 2), subjects completed the Serial Sevens Subtraction Test (S7), Trail Making Test Part A (TMA) and Part B (TMB), and Rey's Auditory Verbal Learning Test (RAVLT) to measure cognitive function...
November 2016: Experimental Gerontology
Baixi Zhang, Yuhang Song, Haiqin Chen, Hao Zhang, Wei Chen
OBJECTIVE: To improve the production of trans-10,cis-12-conjugated linoleic acid (t10,c12-CLA) from linoleic acid in recombinant Yarrowia lipolytica. RESULTS: Cells of the yeast were permeabilized by freeze/thawing. The optimal conditions for t10,c12-CLA production by the permeabilized cells were at 28 °C, pH 7, 200 rpm with 1.5 g sodium acetate l(-1), 100 g wet cells l(-1), and 25 g LA l(-1). Under these conditions, the permeabilized cells produced 15.6 g t10,c12-CLA l(-1) after 40 h, with a conversion yield of 62 %...
November 2016: Biotechnology Letters
Arman Arab, Shahab Aldin Akbarian, Reza Ghiyasvand, Maryam Miraghajani
Recently prevention strategies for breast cancer are focused on lifestyle modification such as diet. Some dietary factors such as Conjugated linoleic acid (CLA) can lower the risk of breast cancer, metastasis and some factors concerning this malignancy. Many studies have been established in this field, but their results are inconsistent. Therefore, we evaluated this association based on systematic review among published scientific literature. We performed an electronic search using PubMed, Cochrane, Scopus, Google Scholar and Persian database (Iran Medex, magiran) to identify relevant studies...
2016: Advanced Biomedical Research
Rashmi Holur Kadirareddy, Sujana Ghanta Vemuri, Uma Maheswari Devi Palempalli
Conjugated linoleic acid, a functional lipid, produced from Lactobacillus plantarum (LPCLA), has been demonstrated to possess apoptotic activity. The antiproliferative and apoptotic potential of LPCLA was here evaluated in vitro using the MDAMB231 human breast cancer cell line as a model system. Proliferation of MDA MB231 cells was inhibited with increasing concentrations of LPCLA with altered morphological features like cell detachment, rounding of cells and oligonucleosomal fragmentation of DNA. Flow cytometry confirmed the apoptotic potential of LPCLA by ANNEXIN V/PI double staining...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
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