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Conjugated linoleic acid

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https://www.readbyqxmd.com/read/28434739/the-effect-of-conjugated-linoleic-acid-acetate-and-their-interaction-on-adipose-tissue-lipid-metabolism-in-nonlactating-cows
#1
N Urrutia, Y Ying, K J Harvatine
During biohydrogenation-induced milk fat depression, adipose tissue lipogenesis may be increased through nutrients spared from milk fat synthesis. However, the direct effect of trans-10, cis-12 conjugated linoleic acid (CLA) and the indirect effect of spared nutrients on adipose tissue lipogenesis during milk fat depression is not clear. The objective of this study was to determine the direct effect of CLA, spared acetate, and their interaction on adipose tissue lipogenesis using nonlactating dairy cows as an experimental model, which allows separation of the effect of CLA and nutrient sparing...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28433853/addition-of-an-extract-of-lucerne-medicago-sativa-l-to-cattle-diets-effects-on-fatty-acid-profile-meat-quality-and-eating-quality-of-the-m-longissimus-muscle
#2
Siân B MacKintosh, Ian Richardson, Eun Joong Kim, Dirk Dannenberger, Didier Coulmier, Nigel D Scollan
There is considerable interest in enhancing beneficial fatty acids, particularly 18:3n-3, conjugated linoleic acid and long chain n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in beef to provide benefits to human health. Here, the potential to enhance these fatty acids by feeding a n-3 polyunsaturated fatty acid (PUFA)-rich plant extract (PX) from lucerne is presented. Cattle (n=8/diet) were assigned to the following finishing diets: straw and concentrate (S-CC); straw and concentrate containing 25% PX and 2000IUvitaminE/kg PX-concentrate (S-PXC); grass silage (GS); GS plus 75gPX/kg dry matter intake (DMI) (GS-LPX) or GS plus 150g PX/kg DMI (GS-HPX)...
April 8, 2017: Meat Science
https://www.readbyqxmd.com/read/28424210/ucp2-attenuates-apoptosis-of-tubular-epithelial-cells-in-renal-ischemia-reperfusion-injury
#3
Yang Zhou, Ting Cai, Jing Xu, Lei Jiang, Jining Wu, Qi Sun, Ke Zen, Junwei Yang
Uncoupling protein 2 (UCP2) plays critical roles in energy metabolism and cell survival. Previous investigations showed that UCP2 regulated the production of extracellular matrix and renal fibrosis. However, little is known about UCP2 in acute kidney injury. Here, we used UCP2 knockout mice to investigate the role of UCP2 in AKI model generated by renal ischemia/reperfusion (I/R) injury. The UCP2 global knockout mice were born and growth normal without kidney histological abnormality or renal dysfunctions. As compared with littermates, deletion of UCP2 exacerbated I/R-induced AKI while increase of UCP2 by conjugated linoleic acid (CLA) attenuated I/R injury...
April 19, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28409336/dietary-docosahexaenoic-acid-and-trans-10-cis-12-conjugated-linoleic-acid-differentially-alter-oxylipin-profiles-in-mouse-periuterine-adipose-tissue
#4
Yuriko Adkins, Benjamin J Belda, Theresa L Pedersen, Dawn M Fedor, Bruce E Mackey, John W Newman, Darshan S Kelley
Diets containing high n-3 polyunsaturated fatty acids (PUFA) decrease inflammation and the incidence of chronic diseases including cardiovascular disease and nonalcoholic fatty liver disease while trans-fatty acids (TFA) intake increases the incidence of these conditions. Some health benefits of n-3 PUFA are mediated through the impact of their oxygenated metabolites, i.e. oxylipins. The TFA, trans-10, cis-12-conjugated linoleic acid (CLA; 18:2n-6) is associated with adipose tissue (AT) inflammation, oxidative stress, and wasting...
April 13, 2017: Lipids
https://www.readbyqxmd.com/read/28394396/effects-of-immunomodulatory-nutrients-on-growth-performance-and-immune-related-gene-expression-in-layer-chicks-challenged-with-lipopolysaccharide
#5
E L Wils-Plotz, K C Klasing
Immunomodulatory nutrients alter the immune response to pathogens. This study was conducted to determine the effects of immunomodulatory nutrients on the immune response to a lipopolysaccharide (LPS) challenge of layer chicks fed supplemental corn oil (control; 3%), fish oil (3%), conjugated linoleic acid (CLA; 1%), lutein (0.05 g/kg), or vitamin E (90 I.U./ kg). Four-week-old layer chicks were allotted to 10 treatment groups arranged as a 2 × 5 factorial with 2 sexes and 5 dietary treatments (TRT; 5 replicate pens of 2 male and 2 female chicks per TRT)...
March 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28387243/linoleic-acid-isomerase-gene-fglai12-affects-sensitivity-to-salicylic-acid-mycelial-growth-and-virulence-of-fusarium-graminearum
#6
Ya-Zhou Zhang, Zhen-Zhen Wei, Cai-Hong Liu, Qing Chen, Bin-Jie Xu, Zhen-Ru Guo, Yong-Li Cao, Yan Wang, Ya-Nan Han, Chen Chen, Xiang Feng, Yuan-Yuan Qiao, Lu-Juan Zong, Ting Zheng, Mei Deng, Qian-Tao Jiang, Wei Li, You-Liang Zheng, Yu-Ming Wei, Peng-Fei Qi
Fusarium graminearum is the major causal agent of fusarium head blight in wheat, a serious disease worldwide. Linoleic acid isomerase (LAI) catalyses the transformation of linoleic acid (LA) to conjugated linoleic acid (CLA), which is beneficial for human health. We characterised a cis-12 LAI gene of F. graminearum (FGSG_02668; FgLAI12), which was downregulated by salicylic acid (SA), a plant defence hormone. Disruption of FgLAI12 in F. graminearum resulted in decreased accumulation of cis-9,trans-11 CLA, enhanced sensitivity to SA, and increased accumulation of LA and SA in wheat spikes during infection...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28380598/dietary-whole-and-cracked-linseed-increases-the-proportion-of-oleic-and-%C3%AE-linolenic-acids-in-adipose-tissues-and-decreases-stearoyl-coenzyme-a-desaturase-acetyl-coenzyme-a-carboxylase-and-fatty-acid-synthase-gene-expression-in-the-longissimus-thoracis-muscle
#7
X Z Li, C G Yan, J Yu, Q S Gao, S H Choi, J S Shin, S B Smith
We hypothesized that supplementation of linseed in a beef cattle fattening diet would increase PUFA concentrations in intramuscular adipose tissue and depress (), (), and () gene expression by decreasing () expression. Conversely, supplemental linseed would upregulate expression of () and () in muscle of Yanbian Yellow steers. Thirty steers were assigned at random to 3 groups of 10 steers fed either the basal diet (corn grain and corn silage-based commercial concentrate [CON]), the CON diet plus 8% whole linseed (WLS; DM basis), or the CON diet plus 8% cracked linseed (CLS; DM basis) for 6 mo...
February 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28370816/effect-of-supplemental-%C3%AE-carotene-compared-to-retinyl-palmitate-on-fatty-acid-profile-and-expression-of-mrna-from-genes-involved-in-vitamin-a-metabolism-in-beef-feedlot-cattle
#8
Kaitlin N Condron, Jolena N Waddell, Matt C Claeys, Ronald P Lemenager, Jon P Schoonmaker
To examine the effects of dietary β-carotene (βC) or retinyl palmitate (RP) on fatty acid (FA) profile and mRNA expression, samples were collected from 24 Angus-cross calves that were allotted to four treatments consisting of RP supplemented at 2200 IU/kg, and synthetic β-carotene (SβC) supplemented at one, five or 10 times RP. Longissimus muscle (LM) cis-9, trans-11 conjugated linoleic acid was greater in RP compared to SβC1X (P = 0.04). The polyunsaturated:saturated FA increased linearly (P = 0.04) in the LM as dietary SβC increased...
March 30, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28359203/distinct-fatty-acid-composition-of-some-edible-by-products-from-bovines-fed-high-or-low-silage-diets
#9
Cristina M Alfaia, Susana P Alves, José M Pestana, Marta S Madeira, Olga Moreira, José Santos-Silva, Rui Jb Bessa, Fidel Toldrá, José Am Prates
In the present study, it was hypothesized that the incorporation of fatty acids is distinct among ruminant tissues and that it could be modulated by diet composition. To test this hypothesis, fatty acid composition, including conjugated linoleic acid isomers, of the most relevant beef by-products (brain, heart, kidney, liver, pancreas and tongue) from young bulls those fed distinct silage levels was assessed. Data indicated a large variation in fatty acid profile and conjugated linoleic acid composition among edible by-products...
April 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28357546/a-metabolic-engineering-strategy-for-producing-conjugated-linoleic-acids-using-the-oleaginous-yeast-yarrowia-lipolytica
#10
Nabila Imatoukene, Jonathan Verbeke, Athanasios Beopoulos, Abdelghani Idrissi Taghki, Brigitte Thomasset, Claude-Olivier Sarde, Maurice Nonus, Jean-Marc Nicaud
Conjugated linoleic acids (CLAs) have been found to have beneficial effects on human health when used as dietary supplements. However, their availability is limited because pure, chemistry-based production is expensive, and biology-based fermentation methods can only create small quantities. In an effort to enhance microbial production of CLAs, four genetically modified strains of the oleaginous yeast Yarrowia lipolytica were generated. These mutants presented various genetic modifications, including the elimination of β-oxidation (pox1-6∆), the inability to store lipids as triglycerides (dga1∆ dga2∆ are1∆ lro1∆), and the overexpression of the Y...
March 29, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28347782/aggregation-of-t10-c12-conjugated-linoleic-acid-in-presence-of-natural-and-modified-cyclodextrins-a-physicochemical-thermal-and-computational-analysis
#11
Adrián Matencio, Francisco García-Carmona, José Manuel López-Nicolás
In this work the aggregation behavior of t10,c12 Conjugated linoleic acid (t10,c12-CLA) is presented for first time. The results show a c.m.c. of 25μM at pH 8 and 25°C. The encapsulation process with cyclodextrins (CDs) presented a 1:1 stoichiometry in all cases studied but the complexation constants were strongly dependent on the type of CDs used, the pH and temperature. Hydroxypropyl-beta-Cyclodextrin (HPβCD) was the best CD studied for encapsulating t10,c12-CLA. The resulting t10,c12-CLA-HPβCD complex showed a very high dependency on pH, which explains why a pKa of 4...
March 25, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28342600/temporal-changes-in-milk-fatty-acid-distribution-due-to-feeding-different-levels-of-rolled-safflower-seeds-to-lactating-holstein-cows
#12
Amir Ahmadpour, Hassan Aliarabi, Mohammad Ghelich Khan, Robert A Patton, Rupert M Bruckmaier
The objective of this experiment was to follow the time-course changes of the milk fatty acids (FA) and particularly conjugated linoleic acid (CLA), n-3, and n-6 FA in response to feeding whole rolled safflower seed (SS). Eighteen cows were blocked by milk production, days in milk, and parity, and randomly assigned to 1 of 3 diets by replacing whole cottonseed with SS. The control diet contained no SS (SS0), whereas the other diets contained 3% of dry matter as SS (SS3) or 6% SS (SS6). The study was conducted for 8 wk...
March 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28330160/characterization-of-cla-producing-butyrivibrio-spp-reveals-strain-specific-variations
#13
S K Asraf Hussain, Anima Srivastava, Ashish Tyagi, Umesh Kumar Shandilya, Ashwani Kumar, Sachin Kumar, Surbhi Panwar, Amrish Kumar Tyagi
Conjugated Linoleic Acid (CLA), a fatty acid with high nutraceutical value is produced in rumen by resident bacterial species, especially Butyrivibrio spp. The present study was undertaken to examine the diversity of indigenous Butyrivibrio spp. from rumen liquor of Indian ruminants. The isolates were screened for their CLA production capability at different level of linoleic acid (LA) (0, 200, 400, 600, 800 μg/ml) at different time intervals (0, 2, 4, 6, 12, and 24 h). A total of more than 300 anaerobic cultures were isolated and 31 of them were identified as Butyrivibrio spp...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28299528/dietary-conjugated-linoleic-acid-c9t11-prevents-collagen-induced-arthritis-whereas-conjugated-linoleic-acid-t10c12-increases-arthritic-severity
#14
Jessica A Muhlenbeck, Daniel E Butz, Jake M Olson, Daniela Uribe-Cano, Mark E Cook
Two conjugated linoleic acid (CLA) isomers, cis-9, trans-11 (CLAc9t11) and trans-10, cis-12 (CLAt10c12), reduce inflammation in a number of animal models, including collagen-induced arthritis (CA). However, little is known about the ability of individual CLA isomers to prevent autoimmune disease onset. Evidence that mixed isomer CLA drives T helper cell (Th) 1 responses suggests that CLA, or a specific isomer, exacerbates onset of Th1 autoimmune diseases. In two experiments, we examined if prior dietary exposure to CLAt10c12 (experiment 1) or CLAc9t11 (experiment 2) affected the incidence or severity of CA...
March 15, 2017: Lipids
https://www.readbyqxmd.com/read/28298694/isolation-molecular-characterization-and-screening-of-indigenous-lactobacilli-for-their-abilities-to-produce-bioactive-conjugated-linoleic-acid-cla
#15
Dinesh Kumar Dahiya, Anil Kumar Puniya
Ingestion of conjugated linoleic acid poised many health benefits; however, amount of CLA one can get through generalized diet in is inadequate in exerting the desired benefits. Therefore, presence of CLA producing lactobacilli in dairy fermented foods has a tremendous potential to increase the CLA content. Therefore, present study was focused to isolate and characterize CLA producing lactobacilli from different dairy products and human faeces. Arguably, 283 lactobacilli were isolated from various sources and tested for CLA production...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28283797/influence-of-nrf2-activators-on-subcellular-skeletal-muscle-protein-and-dna-synthesis-rates-after-6%C3%A2-weeks-of-milk-protein-feeding-in-older-adults
#16
Adam R Konopka, Jaime L Laurin, Robert V Musci, Christopher A Wolff, Justin J Reid, Laurie M Biela, Qian Zhang, Fredrick F Peelor, Christopher L Melby, Karyn L Hamilton, Benjamin F Miller
In older adults, chronic oxidative and inflammatory stresses are associated with an impaired increase in skeletal muscle protein synthesis after acute anabolic stimuli. Conjugated linoleic acid (CLA) and Protandim have been shown to activate nuclear factor erythroid-derived 2-like 2 (Nrf2), a transcription factor for the antioxidant response element and anti-inflammatory pathways. This study tested the hypothesis that compared to a placebo control (CON), CLA and Protandim would increase skeletal muscle subcellular protein (myofibrillar, mitochondrial, cytoplasmic) and DNA synthesis in older adults after 6 weeks of milk protein feeding...
March 10, 2017: GeroScience
https://www.readbyqxmd.com/read/28281023/modification-of-fatty-acid-selectivity-of-candida-antarctica-lipase-a-by-error-prone-pcr
#17
Dagmara Głód
OBJECTIVE: To generate Candida antarctica lipase A (CAL-A) mutants with modified fatty acid selectivities and improved lipolytic activities using error-prone PCR (epPCR). RESULTS: A Candida antarctica lipase A mutant was obtained in three rounds of epPCR. This mutant showed a 14 times higher ability to hydrolyze triacylglycerols containing conjugated linoleic acids, and was 12 and 14 times more selective towards cis-9, trans-11 and trans-10, cis-12 isomers respectively, compared to native lipase...
March 9, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28278390/classification-of-human-milks-based-on-their-trans-18-1-fatty-acid-profile-and-effect-of-maternal-diet
#18
Pilar Gómez-Cortés, Miguel Angel de la Fuente
BACKGROUND: The diet of breastfeeding women influences the trans fatty acid (TFA) composition of the milk excreted. However, the effects associated to TFA are isomer-dependent and diverse TFA profiles may have different nutritional implications. OBJECTIVE: The aim of this research was to evaluate whether certain TFA patterns in human milk fat can be used as indicators of TFA intake from different sources. METHODS: Milk fat from 60 women were examined and classified based on their TFA profile and conjugated linoleic acid (CLA) contents by principal component analysis (PCA)...
March 9, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28276610/the-trans-10-cis-12-conjugated-linoleic-acid-increases-triacylglycerol-hydrolysis-in-yeast-saccharomyces-cerevisiae
#19
Sanna Hokkanen, Simo Laakso, Claudia M Senn, Alexander D Frey
AIMS: The trans-10,cis-12 conjugated linoleic acid (CLA) is known for its antilipogenic effect but the mechanism is not fully clear. In this study, potential of yeast (Saccharomyces cerevisiae) metabolism to offer evidence for the mechanism was investigated. METHODS AND RESULTS: Inhibitory effect of CLA on lipid accumulation was studied by analyzing the transcript abundance of selected genes involved in TAG synthesis (LRO1, DGA1, ARE1 and ARE2) in the presence of the two bioactive CLA isomers: trans-10,cis-12 and the cis-9,trans-11 CLA...
March 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28273203/liver-metabolic-changes-induced-by-conjugated-linoleic-acid-in-calorie-restricted-rats
#20
Camila de Moraes, Camila Andrea de Oliveira, Maria Esméria Corezola do Amaral, Gabriela Arcurio Landini, Rosana Catisti
Objective: Complexes like conjugated linoleic acid (CLA) reduce the percentage of body fat by increasing energy expenditure, fat oxidation, or both. The aim of this study was to verify if CLA is able to mimic caloric restriction (CR), and determine the effects of CLA on liver metabolic profile of young adult male Wistar rats. Materials and methods: We divided 36 animals into the following groups: 1) Control; 2) CLA (1% of daily food intake, 21 days, orogastric intubation); 3) Restr (fed 60% of the diet offered to controls); and 4) CLA Restr...
January 2017: Archives of Endocrinology and Metabolism
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