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Conjugated linoleic acid

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https://www.readbyqxmd.com/read/28342600/temporal-changes-in-milk-fatty-acid-distribution-due-to-feeding-different-levels-of-rolled-safflower-seeds-to-lactating-holstein-cows
#1
Amir Ahmadpour, Hassan Aliarabi, Mohammad Ghelich Khan, Robert A Patton, Rupert M Bruckmaier
The objective of this experiment was to follow the time-course changes of the milk fatty acids (FA) and particularly conjugated linoleic acid (CLA), n-3, and n-6 FA in response to feeding whole rolled safflower seed (SS). Eighteen cows were blocked by milk production, days in milk, and parity, and randomly assigned to 1 of 3 diets by replacing whole cottonseed with SS. The control diet contained no SS (SS0), whereas the other diets contained 3% of dry matter as SS (SS3) or 6% SS (SS6). The study was conducted for 8 wk...
March 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28330160/characterization-of-cla-producing-butyrivibrio-spp-reveals-strain-specific-variations
#2
S K Asraf Hussain, Anima Srivastava, Ashish Tyagi, Umesh Kumar Shandilya, Ashwani Kumar, Sachin Kumar, Surbhi Panwar, Amrish Kumar Tyagi
Conjugated Linoleic Acid (CLA), a fatty acid with high nutraceutical value is produced in rumen by resident bacterial species, especially Butyrivibrio spp. The present study was undertaken to examine the diversity of indigenous Butyrivibrio spp. from rumen liquor of Indian ruminants. The isolates were screened for their CLA production capability at different level of linoleic acid (LA) (0, 200, 400, 600, 800 μg/ml) at different time intervals (0, 2, 4, 6, 12, and 24 h). A total of more than 300 anaerobic cultures were isolated and 31 of them were identified as Butyrivibrio spp...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28299528/dietary-conjugated-linoleic-acid-c9t11-prevents-collagen-induced-arthritis-whereas-conjugated-linoleic-acid-t10c12-increases-arthritic-severity
#3
Jessica A Muhlenbeck, Daniel E Butz, Jake M Olson, Daniela Uribe-Cano, Mark E Cook
Two conjugated linoleic acid (CLA) isomers, cis-9, trans-11 (CLAc9t11) and trans-10, cis-12 (CLAt10c12), reduce inflammation in a number of animal models, including collagen-induced arthritis (CA). However, little is known about the ability of individual CLA isomers to prevent autoimmune disease onset. Evidence that mixed isomer CLA drives T helper cell (Th) 1 responses suggests that CLA, or a specific isomer, exacerbates onset of Th1 autoimmune diseases. In two experiments, we examined if prior dietary exposure to CLAt10c12 (experiment 1) or CLAc9t11 (experiment 2) affected the incidence or severity of CA...
March 15, 2017: Lipids
https://www.readbyqxmd.com/read/28298694/isolation-molecular-characterization-and-screening-of-indigenous-lactobacilli-for-their-abilities-to-produce-bioactive-conjugated-linoleic-acid-cla
#4
Dinesh Kumar Dahiya, Anil Kumar Puniya
Ingestion of conjugated linoleic acid poised many health benefits; however, amount of CLA one can get through generalized diet in is inadequate in exerting the desired benefits. Therefore, presence of CLA producing lactobacilli in dairy fermented foods has a tremendous potential to increase the CLA content. Therefore, present study was focused to isolate and characterize CLA producing lactobacilli from different dairy products and human faeces. Arguably, 283 lactobacilli were isolated from various sources and tested for CLA production...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28283797/influence-of-nrf2-activators-on-subcellular-skeletal-muscle-protein-and-dna-synthesis-rates-after-6%C3%A2-weeks-of-milk-protein-feeding-in-older-adults
#5
Adam R Konopka, Jaime L Laurin, Robert V Musci, Christopher A Wolff, Justin J Reid, Laurie M Biela, Qian Zhang, Fredrick F Peelor, Christopher L Melby, Karyn L Hamilton, Benjamin F Miller
In older adults, chronic oxidative and inflammatory stresses are associated with an impaired increase in skeletal muscle protein synthesis after acute anabolic stimuli. Conjugated linoleic acid (CLA) and Protandim have been shown to activate nuclear factor erythroid-derived 2-like 2 (Nrf2), a transcription factor for the antioxidant response element and anti-inflammatory pathways. This study tested the hypothesis that compared to a placebo control (CON), CLA and Protandim would increase skeletal muscle subcellular protein (myofibrillar, mitochondrial, cytoplasmic) and DNA synthesis in older adults after 6 weeks of milk protein feeding...
March 10, 2017: Geroscience
https://www.readbyqxmd.com/read/28281023/modification-of-fatty-acid-selectivity-of-candida-antarctica-lipase-a-by-error-prone-pcr
#6
Dagmara Głód
OBJECTIVE: To generate Candida antarctica lipase A (CAL-A) mutants with modified fatty acid selectivities and improved lipolytic activities using error-prone PCR (epPCR). RESULTS: A Candida antarctica lipase A mutant was obtained in three rounds of epPCR. This mutant showed a 14 times higher ability to hydrolyze triacylglycerols containing conjugated linoleic acids, and was 12 and 14 times more selective towards cis-9, trans-11 and trans-10, cis-12 isomers respectively, compared to native lipase...
March 9, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28278390/classification-of-human-milks-based-on-their-trans-18-1-fatty-acid-profile-and-effect-of-maternal-diet
#7
Pilar Gómez-Cortés, Miguel Angel de la Fuente
BACKGROUND: The diet of breastfeeding women influences the trans fatty acid (TFA) composition of the milk excreted. However, the effects associated to TFA are isomer-dependent and diverse TFA profiles may have different nutritional implications. OBJECTIVE: The aim of this research was to evaluate whether certain TFA patterns in human milk fat can be used as indicators of TFA intake from different sources. METHODS: Milk fat from 60 women were examined and classified based on their TFA profile and conjugated linoleic acid (CLA) contents by principal component analysis (PCA)...
March 9, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28276610/the-trans-10-cis-12-conjugated-linoleic-acid-increases-triacylglycerol-hydrolysis-in-yeast-saccharomyces-cerevisiae
#8
Sanna Hokkanen, Simo Laakso, Claudia M Senn, Alexander D Frey
AIMS: The trans-10,cis-12 conjugated linoleic acid (CLA) is known for its antilipogenic effect but the mechanism is not fully clear. In this study, potential of yeast (Saccharomyces cerevisiae) metabolism to offer evidence for the mechanism was investigated. METHODS AND RESULTS: Inhibitory effect of CLA on lipid accumulation was studied by analyzing the transcript abundance of selected genes involved in TAG synthesis (LRO1, DGA1, ARE1 and ARE2) in the presence of the two bioactive CLA isomers: trans-10,cis-12 and the cis-9,trans-11 CLA...
March 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28273203/liver-metabolic-changes-induced-by-conjugated-linoleic-acid-in-calorie-restricted-rats
#9
Camila de Moraes, Camila Andrea de Oliveira, Maria Esméria Corezola do Amaral, Gabriela Arcurio Landini, Rosana Catisti
Objective: Complexes like conjugated linoleic acid (CLA) reduce the percentage of body fat by increasing energy expenditure, fat oxidation, or both. The aim of this study was to verify if CLA is able to mimic caloric restriction (CR), and determine the effects of CLA on liver metabolic profile of young adult male Wistar rats. Materials and methods: We divided 36 animals into the following groups: 1) Control; 2) CLA (1% of daily food intake, 21 days, orogastric intubation); 3) Restr (fed 60% of the diet offered to controls); and 4) CLA Restr...
January 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28265110/bifidobacterium-breve-with-%C3%AE-linolenic-acid-alters-the-composition-distribution-and-transcription-factor-activity-associated-with-metabolism-and-absorption-of-fat
#10
Elaine Patterson, Rebecca Wall, Sara Lisai, R Paul Ross, Timothy G Dinan, John F Cryan, Gerald F Fitzgerald, Sebastiano Banni, Eamonn M Quigley, Fergus Shanahan, Catherine Stanton
This study focused on the mechanisms that fatty acid conjugating strains - Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in combination with B. breve NCIMB 702258 or B. breve DPC 6330 (10(9) CFU/day) or unsupplemented control diet for six weeks. The overall n-3 PUFA score was increased in all groups receiving the ALA enriched diet...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28246442/effects-of-different-vegetable-oils-on-rumen-fermentation-and-conjugated-linoleic-acid-concentration-in-vitro
#11
Amitava Roy, Guru Prasad Mandal, Amlan Kumar Patra
AIM: The objective of this study was to investigate the effect of different vegetable oils on rumen fermentation and concentrations of beneficial cis-9 trans-11 C18:2 conjugated linoleic acid (CLA) and trans-11 C18:1 fatty acid (FA) in the rumen fluid in an in vitro condition. MATERIALS AND METHODS: Six vegetable oils including sunflower, soybean, sesame, rice bran, groundnut, and mustard oils were used at three dose levels (0%, 3% and 4% of substrate dry matter [DM] basis) in three replicates for each treatment in a completely randomized design using 6 × 3 factorial arrangement...
January 2017: Veterinary World
https://www.readbyqxmd.com/read/28245284/metabolically-distinct-weight-loss-by-10-12-cla-and-caloric-restriction-highlight-the-importance-of-subcutaneous-white-adipose-tissue-for-glucose-homeostasis-in-mice
#12
Laura J den Hartigh, Shari Wang, Leela Goodspeed, Tomasz Wietecha, Barbara Houston, Mohamed Omer, Kayoko Ogimoto, Savitha Subramanian, G A Nagana Gowda, Kevin D O'Brien, Karl J Kaiyala, Gregory J Morton, Alan Chait
BACKGROUND: Widely used as a weight loss supplement, trans-10,cis-12 conjugated linoleic acid (10,12 CLA) promotes fat loss in obese mice and humans, but has also been associated with insulin resistance. OBJECTIVE: We therefore sought to directly compare weight loss by 10,12 CLA versus caloric restriction (CR, 15-25%), an acceptable healthy method of weight loss, to determine how 10,12 CLA-mediated weight loss fails to improve glucose metabolism. METHODS: Obese mice with characteristics of human metabolic syndrome were either supplemented with 10,12 CLA or subjected to CR to promote weight loss...
2017: PloS One
https://www.readbyqxmd.com/read/28245153/strategies-for-producing-and-incorporating-conjugated-linoleic-acid-rich-oils-in-foods
#13
Sara E Shinn, Chuan Min Ruan, Andrew Proctor
Conjugated linoleic acid (CLA) is in ruminant-derived foods and is known to combat obesity-related diseases. However, CLA levels in a healthy diet are too low to produce a clinical effect. Therefore, CLA has been produced by linoleic isomerization through fermentation and chemical catalysis. Many of these techniques are not practical for food production, but a recent development has enabled production of CLA-rich triglyceride vegetable oils from high linoleic acid oils by a minor modification of conventional food-oil processing techniques...
February 28, 2017: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/28237598/characterization-of-major-and-trace-minerals-fatty-acid-composition-and-cholesterol-content-of-protected-designation-of-origin-cheeses
#14
C L Manuelian, S Currò, M Penasa, M Cassandro, M De Marchi
Cheese provides essential nutrients for human nutrition and health, such as minerals and fatty acids (FA). Its composition varies according to milk origin (e.g., species and breed), rearing conditions (e.g., feeding and management), and cheese-making technology (e.g., coagulation process, addition of salt, ripening period). In recent years, cheese production has increased worldwide. Italy is one of the main producers and exporters of cheese. This study aimed to describe mineral, FA, and cholesterol content of 133 samples from 18 commercial cheeses from 4 dairy species (buffalo, cow, goat, and sheep) and from 3 classes of moisture content (hard, <35% moisture; semi-hard, 35-45%; and soft, >45%)...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28235903/effects-of-supplementation-with-docosahexaenoic-acid-on-reproduction-of-dairy-cows
#15
Leticia D P Sinedino, Paula M Honda, Letícia Ramos Lucena Souza, Adam L Lock, Maurice P Boland, Cr Staples, William W Thatcher, Jose E P Santos
Objectives were to determine the effects of supplementing docosahexaenoic acid (DHA)-rich algae on reproduction of dairy cows. Holstein cows were assigned randomly to either a control (n = 373) or the same diet supplemented daily with 100 g/cow of an algae product containing 10% DHA (Algae, n = 366) from 27 to 147 days postpartum. Measurements included yields of milk and milk components, fatty acids (FA) profiles in milk fat and plasma phospholipids, resumption of ovulation by 57 days postpartum, pregnancy per artificial insemination (AI), and expression of interferon-stimulated genes in leukocytes...
February 24, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28194261/gelidium-amansii-extract-ameliorates-obesity-by-down-regulating-adipogenic-transcription-factors-in-diet-induced-obese-mice
#16
Ji-Hye Kang, Hyun-Ah Lee, Hak-Ju Kim, Ji-Sook Han
BACKGROUND/OBJECTIVES: In this study, we investigated whether Gelidium amansii extract (GAE) ameliorates obesity in diet-induced obese (DIO) mice. MATERIALS/METHODS: The mice were maintained on a high-fat diet (HD) for 5 weeks to generate the DIO mouse model. And then mice fed HD plus 0.5% (GAE1), 1% (GAE2) or 2% (GAE3) for 8 weeks. RESULTS: After the experimental period, GAE-supplemented groups were significantly lower than the HD group in body weight gain and liver weight...
February 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28176632/effect-of-conjugated-linoleic-acid-as-a-supplement-or-enrichment-in-foods-on-blood-glucose-and-waist-circumference-in-humans-a-meta-analysis
#17
Ali Reza Rahbar, Afshin Ostvar, Seyedeh-Masomeh Derakhshandeh-Rishehri, Leila Janani, Amin Rahbar
BACKGROUND: Controversy persists regarding the effect of mixtures of conjugated linoleic acids (c9,t11- and t12,c10-CLA) in fasting blood glucose (FBG) and waist circumference (WC) in humans. OBJECTIVE: The aim of this meta-analysis is to explore the effect of CLA on FBG and WC. METHOD: PubMed, Google Scholar, Cochrane Library, Science Direct, Pro-Quest and Ovid were searched up to January 2015. Studies that examined the effect of CLA supplementation or foods enriched with CLA on FBG and WC in healthy adults were included...
February 7, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28176378/effects-of-supplemental-conjugated-linoleic-acids-cla-on-fresh-and-post-thaw-sperm-quality-of-holstein-bulls
#18
R Karimi, A Towhidi, S Zeinoaldini, K Rezayazdi, M Mousavi, H Safari, F Martinez-Pastor
This study was designed to investigate the effects of feeding-protected conjugated linoleic acid (CLA) on the semen production and sperm freezability in Holstein bulls. Twelve bulls were randomly assigned to two groups (n = 6 per group). Bulls received the normal diet (control group) or the normal diet top-dressed with 50 g of CLA (treated group) for 10 weeks. The control group received 40 g/day calcium soap of fatty acid. Fresh and post-thaw semen quality was assessed on ejaculates collected at the 0, 4, 6, 8 and 10 week of supplementation...
February 7, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28161177/influence-of-conjugated-linoleic-acid-and-vitamin-e-on-performance-energy-metabolism-and-change-of-fat-depot-mass-in-transitional-dairy-cows
#19
S Schäfers, D von Soosten, U Meyer, C Drong, J Frahm, J Kluess, C Raschka, J Rehage, A Tröscher, W Pelletier, S Dänicke
The objective of this experiment was to determine the effects of conjugated linoleic acid (CLA) and vitamin E as well as their interaction on performance variables and lipomobilization during late pregnancy and early lactation (wk 6 antepartum until wk 10 postpartum). For this purpose, 59 pluriparous German Holstein cows were assigned to 4 dietary groups in a 2 × 2 design with the factors CLA and vitamin E at 2 levels. For this trial, we selected cows with a high body condition score because they are more likely to mobilize fat and consequently are at a higher risk of developing ketosis...
February 1, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28125600/conjugated-linoleic-acid-administration-induces-amnesia-in-male-sprague-dawley-rats-and-exacerbates-recovery-from-functional-deficits-induced-by-a-controlled-cortical-impact-injury
#20
Rastafa I Geddes, Kentaro Hayashi, Quinn Bongers, Marlyse Wehber, Icelle M Anderson, Alex D Jansen, Chase Nier, Emily Fares, Gabrielle Farquhar, Amita Kapoor, Toni E Ziegler, Sivan VadakkadathMeethal, Ian M Bird, Craig S Atwood
Long-chain polyunsaturated fatty acids like conjugated linoleic acids (CLA) are required for normal neural development and cognitive function and have been ascribed various beneficial functions. Recently, oral CLA also has been shown to increase testosterone (T) biosynthesis, which is known to diminish traumatic brain injury (TBI)-induced neuropathology and reduce deficits induced by stroke in adult rats. To test the impact of CLA on cognitive recovery following a TBI, 5-6 month old male Sprague Dawley rats received a focal injury (craniectomy + controlled cortical impact (CCI; n = 17)) or Sham injury (craniectomy alone; n = 12) and were injected with 25 mg/kg body weight of Clarinol® G-80 (80% CLA in safflower oil; n = 16) or saline (n = 13) every 48 h for 4 weeks...
2017: PloS One
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