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Conjugated linoleic acid

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https://www.readbyqxmd.com/read/27913584/nitro-fatty-acid-pharmacokinetics-in-the-adipose-tissue-compartment
#1
Marco Fazzari, Nicholas K H Khoo, Steven R Woodcock, Diane K Jorkasky, Lihua Li, Francisco J Schopfer, Bruce A Freeman
Electrophilic nitro-fatty acids (NO2-FAs) promote adaptive and anti-inflammatory cell signaling responses as a result of an electrophilic character that supports post-translational protein modifications. A unique pharmacokinetic profile is expected for NO2-FAs because of an ability to undergo reversible reactions including Michael additions with biological cysteine-containing proteins and esterification into complex lipids. Herein we report via quantitative whole-body autoradiography analysis of rats gavaged with radiolabeled 10-nitro-[14C]oleic acid, preferential accumulation in adipose tissue over two weeks...
December 2, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27898407/expression-pattern-and-regulatory-role-of-microrna-23a-in-conjugated-linoleic-acids-induced-apoptosis-of-adipocytes
#2
Renli Qi, Qi Wang, Jing Wang, Jinxiu Huang, Shan Jiang, Rong Xiao, Zuohua Liu, Feiyun Yang
BACKGROUND/AIMS: Conjugated linoleic acids (CLAs) are known to induce apoptosis in adipocytes; however, the cellular mechanisms involved remained illdefined. We explored the different apoptotic induction effects of two CLA isomers on adipocytes and then investigated the expression and function of microRNAs (miRNAs) related to the apoptosis. METHODS: TUNEL and FCM assays were used to detect CLAs-induced adipocyte apoptosis. Microarrays were used to compare the differential expression of miRNAs...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27897090/the-effect-of-commercial-conjugated-linoleic-acid-products-on-experimental-periodontitis-and-diabetes-mellitus-in-wistar-rats
#3
Hatice Balci Yuce, Nihat Akbulut, Seda Ocakli, Omer Kayir, Mahfuz Elmastas
OBJECTIVE: The aim of present study was to determine the effects of conjugated linoleic acid enriched milk on alveolar bone loss, hyperglycaemia, oxidative stress and apoptosis in ligature-induced periodontal disease in diabetic rat model. METHODS: Wistar rats were divided into six experimental groups: 1; non-ligated (NL, n = 6) group, 2; ligature only (LO, n = 6) group, 3; streptozotocin only (STZ, n = 8) group, 4; STZ and ligature (STZ + L, n = 8) group, 5; ligature and conjugated linoleic acid (CLA) (L + CLA, n = 8) group, 6; STZ, ligature and CLA group (STZ + L + CLA, n = 8) group...
November 29, 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27884102/gene-expression-profile-of-intramuscular-muscle-in-nellore-cattle-with-extreme-values-of-fatty-acid
#4
Mariana P Berton, Larissa F S Fonseca, Daniela F J Gimenez, Bruno L Utembergue, Aline S M Cesar, Luiz L Coutinho, Marcos Vinicius A de Lemos, Carolyn Aboujaoude, Angélica S C Pereira, Rafael M de O Silva, Nedenia B Stafuzza, Fabieli L B Feitosa, Hermenegildo L J Chiaia, Bianca F Olivieri, Elisa Peripolli, Rafael L Tonussi, Daniel M Gordo, Rafael Espigolan, Adrielle M Ferrinho, Lenise F Mueller, Lucia G de Albuquerque, Henrique N de Oliveira, Susan Duckett, Fernando Baldi
BACKGROUND: Fatty acid type in beef can be detrimental to human health and has received considerable attention in recent years. The aim of this study was to identify differentially expressed genes in longissimus thoracis muscle of 48 Nellore young bulls with extreme phenotypes for fatty acid composition of intramuscular fat by RNA-seq technique. RESULTS: Differential expression analyses between animals with extreme phenotype for fatty acid composition showed a total of 13 differentially expressed genes for myristic (C14:0), 35 for palmitic (C16:0), 187 for stearic (C18:0), 371 for oleic (C18:1, cis-9), 24 for conjugated linoleic (C18:2 cis-9, trans11, CLA), 89 for linoleic (C18:2 cis-9,12 n6), and 110 genes for α-linolenic (C18:3 n3) fatty acids...
November 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27878919/effect-of-health-status-on-fattening-performance-in-young-crossbred-polish-holstein-friesian-%C3%A3-limousin-bulls-and-steers
#5
Zofia Wielgosz-Groth, Monika Sobczuk-Szul, Zenon Nogalski, Paulina Pogorzelska-Przybyłek, Cezary Purwin
The aim of this study was to determine the effect of disease incidence on selected parameters of cattle fattening performance and carcass quality, and the fatty acid profile of beef. The experimental materials comprised 16 bulls and 16 steers, Polish Holstein-Friesian × Limousin crossbreeds (including 10 healthy and six treated animals of each category). At 5 weeks of age, bloodless castration was carried out using a rubber elastrator. The calves were fed milk replacer provided in automatic feeding stations...
November 23, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27878911/effect-of-increased-feeding-of-dietary-%C3%AE-linolenic-acid-by-grazing-on-formation-of-the-cis9-trans11-18-2-isoform-of-conjugated-linoleic-acid-in-bovine-milk
#6
Mio Yamaguchi, Taki Naito, Yoshikazu Nagao, Yukihito Kabuyama, Kei Hashimoto, Norihiro Azuma, Isamu Maeda
Feeding systems such as grazing affect the fatty acid profile of bovine milk fat. In addition, milk fat is formed as the product of fatty acid metabolism in cow bodies before being secreted into milk. However, how grazing influences milk fatty acid profile through the metabolism has not been completely characterized. When fatty acid concentrations in Holstein milk were compared between grazing and non-grazing periods, α-linolenic acid was significantly higher in the grazing period than in the non-grazing period...
November 23, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27875996/differences-in-the-skeletal-muscle-transcriptome-profile-associated-with-extreme-values-of-fatty-acids-content
#7
Aline S M Cesar, Luciana C A Regitano, Mirele D Poleti, Sónia C S Andrade, Polyana C Tizioto, Priscila S N Oliveira, Andrezza M Felício, Michele L do Nascimento, Amália S Chaves, Dante P D Lanna, Rymer R Tullio, Renata T Nassu, James E Koltes, Eric Fritz-Waters, Gerson B Mourão, Adhemar Zerlotini-Neto, James M Reecy, Luiz L Coutinho
BACKGROUND: Lipids are a class of molecules that play an important role in cellular structure and metabolism in all cell types. In the last few decades, it has been reported that long-chain fatty acids (FAs) are involved in several biological functions from transcriptional regulation to physiological processes. Several fatty acids have been both positively and negatively implicated in different biological processes in skeletal muscle and other tissues. To gain insight into biological processes associated with fatty acid content in skeletal muscle, the aim of the present study was to identify differentially expressed genes (DEGs) and functional pathways related to gene expression regulation associated with FA content in cattle...
November 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27873315/incorporation-of-conjugated-fatty-acids-into-nile-tilapia-oreochromis-niloticus
#8
Elton G Bonafé, Luana C de Figueiredo, Alessandro F Martins, Johny P Monteiro, Oscar O S Junior, Edmilson A Canesin, Swami Arêa Maruyama, Jesuí V Visentainer
The aim of this work was to improve the nutritional quality of Nile tilapia meat through enriched diets with conjugated isomers of linolenic acid from tung oil. The transfer process of conjugated fatty acids (CFA) into fish muscle tissue was evaluated by gas chromatography-flame ionization detection (GC-FID) and Easy Ambient Sonic-Spray Ionization Mass Spectrometry (EASI-MS). The results showed that conjugated fatty acids were transferred from enriched diet for muscle tissue of Nile tilapia. Conjugated linoleic acids biosynthesis from conjugated linolenic acids was also observed after ten days...
November 21, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27865506/synthesis-of-the-suspected-trans-11-cis-13-conjugated-linoleic-acid-isomer-in-ruminant-mammary-tissue-by-fads3-catalyzed-%C3%AE-13-desaturation-of-vaccenic-acid
#9
Cyrielle Garcia, Cécile Duby, Daniel Catheline, Pablo G Toral, Laurence Bernard, Philippe Legrand, Vincent Rioux
The octadecadienoic conjugated linoleic acid (CLA) isomer with trans-11 and cis-13 double bonds (trans-11,cis-13 CLA) has been described in ruminant milk. For now, this specific CLA is suspected to derive exclusively from ruminal biohydrogenation of dietary α-linolenic acid. However, in rodents, the fatty acid desaturase 3 (FADS3) gene was recently shown to code for an enzyme able to catalyze the unexpected Δ13-desaturation of vaccenic acid, producing a Δ11,13-CLA with all the structural characteristics of the trans-11,cis-13 isomer, although no commercial standard exists for complete conclusive identification...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27843307/the-effect-of-conjugated-linoleic-acid-supplementation-on-the-nutritional-status-of-copd-patients
#10
Hassan Ghobadi, Somaieh Matin, Ali Nemati, Abbas Naghizadeh-Baghi
BACKGROUND: COPD patients are susceptible to anorexia, reduction of caloric intake, weight loss, and malnutrition. One of the possible mechanisms is the increase of inflammatory markers such as interleukin 1β (IL1β), is highly correlated with anorexia. Considering the anti-inflammatory role of conjugated linoleic acid (CLA), this study aimed to investigate the effect of CLA supplementation on the nutritional status of COPD patients. PATIENTS AND METHODS: In a double-blind clinical trial, 93 COPD patients who volunteered to participate in the study and who filled out a written consent form, were randomly assigned to control or supplementation groups...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27834186/twelve-week-conjugated-linoleic-acid-supplementation-has-no-effects-on-the-selected-markers-of-atherosclerosis-in-obese-and-overweight-women
#11
Monika Dus-Zuchowska, Edyta Madry, Patrycja Krzyzanowska, Paweł Bogdanski, Jaroslaw Walkowiak
BACKGROUND: The antiatherogenic effect of conjugated linoleic acid (CLA) has been demonstrated in animal models. Although there are plenty of in vitro studies that suggest the profitable properties of CLA, the results in humans remain inconsistent. OBJECTIVE: In this study, we assessed the impact of CLA supplementation on the levels of atherosclerosis markers - high-sensitivity C-reactive protein (hs-CRP) and asymmetrical dimethylarginine (ADMA). DESIGN: Seventy-four adult female subjects with body mass index ≥25 kg/m(2) were enrolled in the double-blind, placebo-controlled nutritional intervention...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27815799/cla-has-a-useful-effect-on-bone-markers-in-patients-with-rheumatoid-arthritis
#12
N Aryaeian, F Shahram, M Djalali
: Rheumatoid arthritis is a systemic, chronic disease which may increase the risk of osteoporosis. This study was carried out in order to examine the effect of conjugated linoleic acid (CLA) on bone markers in rheumatoid arthritis disease which is the most common autoimmune disease. The present study is a randomized double-blind clinical trial. Subjects included 52 patients with active rheumatoid arthritis who were divided into two groups. Group I received standard treatment plus 2 daily 1...
November 4, 2016: Lipids
https://www.readbyqxmd.com/read/27812039/a-self-assembling-nanomedicine-of-conjugated-linoleic-acid-paclitaxel-conjugate-cla-ptx-with-higher-drug-loading-and-carrier-free-characteristic
#13
Ting Zhong, Xin Yao, Shuang Zhang, Yang Guo, Xiao-Chuan Duan, Wei Ren, Dan Huang, Yi-Fan Yin, Xuan Zhang
The main objective of this study was to demonstrate the proof-of-principle for the hypothesis that conjugated linoleic acid-paclitaxel conjugate (CLA-PTX), a novel fatty acid modified anti-cancer drug conjugate, could self-assemble forming nanoparticles. The results indicated that a novel self-assembling nanomedicine, CLA-PTX@PEG NPs (about 105 nm), with Cremophor EL (CrEL)-free and organic solvent-free characteristics, was prepared by a simple precipitation method. Being the ratio of CLA-PTX:DSPE-PEG was only 1:0...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27803494/preparation-of-conjugated-linoleic-acid-microemulsions-and-their-biodistribution
#14
Kazuaki Kishita, Kayo Ibaraki, Shoko Itakura, Yumi Yamasaki, Naoko Nishikata, Kenji Yamamoto, Masataka Shimizu, Kazuo Nishiyama, Masao Yamasaki
Conjugated linoleic acid (CLA) has several beneficial biological properties. Specifically, trans10, cis12-CLA, one of the CLA isomers, has strong physiologic activity against cancer and obesity. However, compared with cis9, trans11-CLA, a naturally occurring CLA isomer, trans10, cis12-CLA tends to be easily metabolized. Therefore, to make efficient use of its biological properties, it is necessary to overcome the rapid clearance of trans10, cis12-CLA from the blood. Here, we employed premix membrane emulsification to prepare two oil-in-water CLA microemulsions (CLA-ME), 100 nm CLA-ME and 200 nm CLA-ME, and investigated their pharmacokinetics in a mouse model...
2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27778642/conjugated-linoleic-acid-and-metformin-on-insulin-sensitivity-in-obese-children-randomized-clinical-trial
#15
Nayely Garibay-Nieto, Gloria Queipo-Garcia, Flor Alvarez-Huerta, Mayra Bustos-Esquivel, Erendira Villanueva-Ortega, Fernando Ramirez, Mireya Leon, Estibalitz Laresgoiti-Servitje, Ravindranath Duggirala, Teresa Macias, Sergio Cuevas, Abel Jalife, Miguel Fonseca-Sanchez, Fabiola Serratos, Juan Carlos Lopez-Alvarenga
CONTEXT: Insulin resistance precedes metabolic syndrome abnormalities and may promote cardiovascular disease and type 2 diabetes in children with obesity. Results of lifestyle modification programs have been discouraging, and the use of adjuvant strategies has been necessary. OBJECTIVE: This study aimed to evaluate the effects of metformin and conjugated linoleic acid (CLA) on insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp technique and insulin pathway expression molecules in muscle biopsies of children with obesity...
October 25, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27771086/quality-characteristics-chemical-composition-and-sensory-properties-of-butter-from-cows-on-pasture-versus-indoor-feeding-systems
#16
Tom F O'Callaghan, Hope Faulkner, Stephen McAuliffe, Maurice G O'Sullivan, Deirdre Hennessy, Pat Dillon, Kieran N Kilcawley, Catherine Stanton, R Paul Ross
This study evaluated the effects of 3 widely practiced cow feeding systems in the United States, Europe, and Southern Hemisphere regions on the characteristics, quality, and consumer perception of sweet cream butter. Fifty-four multiparous and primiparous Friesian cows were divided into 3 groups (n = 18) for an entire lactation. Group 1 was housed indoors and fed a total mixed ration diet (TMR) of grass silage, maize silage, and concentrates; group 2 was maintained outdoors on perennial ryegrass-only pasture (GRS); and group 3 was maintained outdoors on a perennial ryegrass/white clover pasture (CLV)...
October 19, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27769894/preparation-isolation-and-identification-of-non-conjugated-c18-2-fatty-acid-isomers
#17
Ali Reza Fardin-Kia
Non-conjugated geometric/positional isomers of linoleic acid (c9,c12-18:2) are often present in processed foods and oils. The following work presents a simple addition/elimination reaction for preparation of non-conjugated 18:2 fatty acid isomers. A mixture containing positional and geometric isomers of C18:2 fatty acids was produced by addition of hydrobromic acid to the fatty acid double bonds, followed by its elimination with a strong sterically hindered base. Pure 8,12-, 8,13-, 9,12-, and 9,13-18:2 fatty acid methyl esters were isolated from the synthetic mixture by a combination of sub-ambient RP-HPLC and Ag(+)-HPLC...
October 18, 2016: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/27766206/transcript-profiling-in-the-liver-of-early-lactating-dairy-cows-fed-conjugated-linoleic-acid
#18
Robert Ringseis, Wilhelm Windisch, Klaus Eder
In the present study, transcript profiling was carried out in liver biopsies from high-yielding dairy cows at week 5 of lactation in order to identify genes and pathways regulated by feeding rumen-protected conjugated linoleic acid (CLA) during the transition period. Analysis of a bovine whole genome microarray revealed a total number of 130 annotated differentially expressed genes (DEGs) in the liver between cows of the CLA group and the control group (filter: P < 0.05 and fold change (FC) ≥ 1.3 or ≤- 1...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27736732/conjugated-linoleic-acid-cla-promotes-endurance-capacity-via-peroxisome-proliferator-activated-receptor-%C3%AE-mediated-mechanism-in-mice
#19
Yoo Kim, Daeyoung Kim, Yeonhwa Park
Previously, it was reported that conjugated linoleic acid (CLA) with exercise training potentially improved endurance capacity via the peroxisome proliferator-activated receptor δ (PPARδ)-mediated mechanism in mice. This study determined the role of exercise and/or CLA in endurance capacity and PPARδ-associated regulators. Male 129Sv/J mice were fed either control (soybean oil) or CLA (0.5%) containing diets for 4 weeks and were further divided into sedentary or training regimes. CLA supplementation significantly reduced body weight and fat mass independent of exercise during the experimental period...
September 7, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27720161/effect-of-pasture-versus-indoor-feeding-systems-on-raw-milk-composition-and-quality-over-an-entire-lactation
#20
Tom F O'Callaghan, Deirdre Hennessy, Stephen McAuliffe, Kieran N Kilcawley, Michael O'Donovan, Pat Dillon, R Paul Ross, Catherine Stanton
The aim of this study was to investigate the effects of different feeding systems on milk quality and composition. Fifty-four multiparous and primiparous Friesian lactating cows were divided into 3 groups (n = 18) to study the effects of 3 feeding systems over a full lactation. Group 1 was housed indoors and offered a total mixed ration diet (TMR), group 2 was maintained outdoors on a perennial ryegrass pasture (referred to as grass), and group 3 was also grazed outdoors on a perennial ryegrass/white clover pasture (referred to as clover)...
October 5, 2016: Journal of Dairy Science
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