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B-vitamins

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https://www.readbyqxmd.com/read/29786139/one-carbon-metabolite-ratios-as-functional-b-vitamin-markers-and-in-relation-to-colorectal-cancer-risk
#1
Björn Gylling, Robin Myte, Arve Ulvik, Per M Ueland, Øivind Midttun, Jörn Schneede, Göran Hallmans, Jenny Häggström, Ingegerd Johansson, Bethany Van Guelpen, Richard Palmqvist
One-carbon metabolism biomarkers are easily measured in plasma, but analyzing them one at a time in relation to disease does not take into account the interdependence of the many factors involved. The relative dynamics of major one-carbon metabolism branches can be assessed by relating the functional B-vitamin marker total homocysteine (tHcy) to transsulfuration (total cysteine) and methylation (creatinine) outputs. We validated the ratios of tHcy to total cysteine (Hcy:Cys), tHcy to creatinine (Hcy:Cre), and tHcy to cysteine to creatinine (Hcy:Cys:Cre) as functional markers of B-vitamin status...
May 22, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29777237/dna-methylation-variant-b-vitamins-intake-and-longitudinal-change-in-body-mass-index
#2
Xiang Li, Tiange Wang, Min Zhao, Tao Huang, Dianjianyi Sun, Liyuan Han, Hoirun Nisa, Xiaoyun Shang, Yoriko Heianza, Lu Qi
BACKGROUND: Growing evidence has implicated DNA methylation (DNAm) in the regulation of body adiposity; a recent epigenome-wide association study (EWAS) identified a genetic variant determining DNAm at the SREBF1 gene that affected body mass index (BMI). OBJECTIVE: In the present study, we tested interactions between DNAm variant rs752579 and methylation metabolism-related B-vitamins (folate, vitamin B2 , vitamin B6 , and vitamin B12 ) on longitudinal change in BMI in the Women's Health Initiative Memory Study (WHIMS)...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29752770/one-carbon-cycle-support-rescues-sperm-damages-in-experimentally-induced-varicocele-in-rats
#3
Parisa Mohammadi, Hassan Hassani Bafrani, Marziyeh Tavalaee, Maurizio Dattilo, Mohammad Hossein Nasr-Esfahani
OBJECTIVES: To demonstrate that micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage following surgical varicocele in rats and that this effect is achieved without suffering a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS: Surgical varicocele was induced in adult male Wistar rats and resulted in significant damage to testis and sperm cells measured 2 and 4 months post-surgery...
May 11, 2018: BJU International
https://www.readbyqxmd.com/read/29747835/b-vitamins-for-stroke-prevention-interaction-of-low-platelet-count-and-high-plasma-total-homocysteine
#4
EDITORIAL
J David Spence, Vladimir Hachinski
No abstract text is available yet for this article.
May 15, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29739477/selected-b-vitamins-and-their-possible-link-to-the-aetiology-of-age-related-sarcopenia-relevance-of-uk-dietary-recommendations
#5
N Aytekin, K N Mileva, A D Cunliffe
The possible roles of selected B vitamins in the development and progression of sarcopenia are reviewed. Age-related declines in muscle mass and function are associated with huge and increasing costs to healthcare providers. Falls and loss of mobility and independence due to declining muscle mass/function are associated with poor clinical outcomes and their prevention and management are attractive research targets. Nutritional status appears a key modifiable and affordable intervention. There is emerging evidence of sarcopenia being the result not only of diminished anabolic activity but also of declining neurological integrity in older age, which is emerging as an important aspect of the development of age-related decline in muscle mass/function...
May 9, 2018: Nutrition Research Reviews
https://www.readbyqxmd.com/read/29737316/perioperative-complications-of-sleeve-gastrectomy-review-of-the-literature
#6
REVIEW
Antonio Iannelli, Patrick Treacy, Lionel Sebastianelli, Luigi Schiavo, Francesco Martini
Sleeve gastrectomy (SG) has known a spectacular rise worldwide during the last decade. The absence of digestive anastomosis simplifies the surgical technique, reducing anastomosis-related complications such as fistula, stricture and marginal ulcer. Furthermore, the respect for digestive continuity preserves the functions of pylorus, that regulates gastric emptying, and duodenum, where calcium, B vitamins and iron are absorbed. Despite the multiple advantages, SG also has specific complications such as bleeding, stenosis, portal thrombosis and leak...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29737293/effect-of-sedative-drugs-with-vitamin-b6-combined-with-other-b-vitamins-in-the-anti-stress-of-captive-amur-tiger
#7
Qiao Zhenglei, Ma Jianzhang
In order to reduce the stress response of animals in animal transportation, it is often used to feed the animals with sedative drugs combined with compound vitamin B. In this article, we will randomly divide 16 amur tiger into the control group and the experimental group. The drug intervention is carried out in the experimental group. The sedative is mainly dexmedetomidine, combined with compound vitamin B, while control group did not feed the drug. The urine of two groups of individuals was collected before and after transportation and the cortisol content in urine was determined by radioimmunoassay as an indication of stress...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29735460/effect-of-sedative-drugs-with-vitamin-b6-combined-with-other-b-vitamins-in-the-anti-stress-of-captive-amur-tiger
#8
Qiao Zhenglei, Ma Jianzhang
In order to reduce the stress response of animals in animal transportation, it is often used to feed the animals with sedative drugs combined with compound vitamin B. In this article, we will randomly divide 16 amur tiger into the control group and the experimental group. The drug intervention is carried out in the experimental group. The sedative is mainly dexmedetomidine, combined with compound vitamin B, while control group did not feed the drug. The urine of two groups of individuals was collected before and after transportation and the cortisol content in urine was determined by radioimmunoassay as an indication of stress...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29728702/elevated-levels-of-brain-homocysteine-directly-modulate-the-pathological-phenotype-of-a-mouse-model-of-tauopathy
#9
Antonio Di Meco, Jian-Guo Li, Carlos Barrero, Salim Merali, Domenico Praticò
A high circulating level of homocysteine (Hcy), also known as hyperhomocysteinemia, is a risk factor for Alzheimer's disease (AD). Previous studies show that elevated Hcy promotes brain amyloidosis and behavioral deficits in mouse models of AD. However, whether it directly modulates the development of tau neuropathology independently of amyloid beta in vivo is unknown. Herein, we investigate the effect of diet-induced elevated levels of brain Hcy on the phenotype of a relevant mouse model of human tauopathy...
May 4, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29728335/plasma-cystathionine-and-risk-of-acute-myocardial-infarction-among-patients-with-coronary-heart-disease-results-from-two-independent-cohorts
#10
Indu Dhar, Gard F T Svingen, Eva R Pedersen, Barbara DeRatt, Arve Ulvik, Elin Strand, Per M Ueland, Kaare H Bønaa, Jesse F Gregory, Ottar K Nygård
BACKGROUND: Cystathionine is a thio-ether and a metabolite formed from homocysteine during transsulfuration. Elevated plasma cystathionine levels are reported in patients with cardiovascular disease; however prospective relationships with acute myocardial infarction (AMI) are unknown. We investigated associations between plasma cystathionine and AMI among patients with suspected and/or verified coronary heart disease (CHD). METHODS: Subjects from two independent cohort studies, the Western Norway Coronary Angiography Cohort (WECAC) (3033 patients with stable angina pectoris; 263 events within 4...
April 21, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29705446/the-effects-of-different-combinations-of-perceptual-motor-exercises-music-and-vitamin-d-supplementation-on-the-nerve-growth-factor-in-children-with-high-functioning-autism
#11
Hadi Moradi, Mehdi Sohrabi, Hamidreza Taheri, Ezzat Khodashenas, Ahmadreza Movahedi
The present study investigated the effects of different combinations of perceptual-motor exercises, music, and Vitamin D consumption on the nerve growth factor (NGF) in children with high-functioning autism. 48 children with autism, aged between six and nine years, were divided into four groups: Group A- perceptual-motor activities along with music (n = 12); Group B-Vitamin D supplementation (n = 12); Group C-perceptual-motor activities along with music and Vitamin D (n = 12); and Group D-control (n = 12)...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29698861/lc-ms-based-urinary-metabolomics-study-of-the-intervention-effect-of-aloe-emodin-on-hyperlipidemia-rats
#12
Hongyu Ji, Yu Liu, Fang He, Ran An, Zhimin Du
Hyperlipidemia has been highlighted to be one of the most prominent and global chronic condition nowadays. Daming capsule (DMC), a traditional Chinese medicine (TCM) preparation, has treated hyperlipidemia on clinic in China for decades. Our recent study showed that aloe-emodin (AE) is one of the main bioactive components in DMC. Therefore, the present study aims to further investigate the lipid-lowering effect by serum biochemistry and histopathological examination, and reveal the underlying mechanisms by urinary metabolomics approach...
April 16, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29685716/homocysteine-and-incident-atrial-fibrillation-the-atherosclerosis-risk-in-communities-study-and-the-multi-ethnic-study-of-atherosclerosis
#13
Yasuhiko Kubota, Alvaro Alonso, Susan R Heckbert, Faye L Norby, Aaron R Folsom
BACKGROUND: Although many studies have investigated the association of blood homocysteine with major cardiovascular diseases such as coronary heart disease and stroke, research on its association with atrial fibrillation (AF) is scarce. METHODS: We analysed data from Atherosclerosis Risk in Communities (ARIC) Study (n=492, age 45-64 years) and Multi-Ethnic Study of Atherosclerosis (MESA) (n=6,641, age 45-84 years). RESULTS: During the 10,106 and 67,613 person-years of follow-up, we identified 85 and 351 AF events in ARIC and MESA, respectively...
March 21, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29681913/toward-eradication-of-b-vitamin-deficiencies-considerations-for-crop-biofortification
#14
REVIEW
Simon Strobbe, Dominique Van Der Straeten
'Hidden hunger' involves insufficient intake of micronutrients and is estimated to affect over two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause an alarming number of casualties, even in the developed world. Many staple crops, although serving as the main dietary component for large population groups, deliver inadequate amounts of micronutrients. Biofortification, the augmentation of natural micronutrient levels in crop products through breeding or genetic engineering, is a pivotal tool in the fight against micronutrient malnutrition (MNM)...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29674265/relationship-between-plasma-levels-of-homocysteine-and-the-related-b-vitamins-in-patients-with-hemodialysis-adequacy-or-inadequacy
#15
En-Ling Yeh, Yi-Chia Huang, Shang-Feng Tsai, Tong-Min Yu, Ming-Ju Wu, Cheng-Hsu Chen
OBJECTIVES: Hemodialysis (HD) with dialysis adequacy could increase the excretion of B vitamins (folate, vitamin B6 , and B12 ) and raise the plasma level of homocysteine. Here we determined the associations of plasma homocysteine with B vitamins in patients with HD adequacy or inadequacy. METHODS: We recruited 68 patients who had received HD treatments (three times a week, 4 h each). Based on the individual's hemogram and quarterly urea reduction rate (Kt/V), patients were pooled into one of the following two groups: the first group with dialysis adequacy (Kt/V > 1...
February 14, 2018: Nutrition
https://www.readbyqxmd.com/read/29672394/effects-of-vitamin-b-complex-and-vitamin-c-on-human-skin-cells-is-the-perceived-effect-measurable
#16
Julian-Dario Rembe, Carolin Fromm-Dornieden, Ewa Klara Stuermer
OBJECTIVE: Vitamins are essential for human health. In terms of local application for wound healing, vitamins' positive effect remains unclear. However, because of the regular appearance of nutritional deficiency in chronic wound patients, a favorable impact of locally applied vitamins can be hypothesized. METHODS: Vitamins B3, B5, B6, B7, B9, B10, B12, and C individually as well as different combinations of B vitamins were investigated regarding their ability to promote proliferation and migration of human skin fibroblasts and keratinocytes...
May 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29665762/effects-of-vitamin-b6-pyridoxine-and-a-b-complex-preparation-on-dreaming-and-sleep
#17
Denholm J Aspy, Natasha A Madden, Paul Delfabbro
Anecdotal evidence indicates that supplementation with vitamin B6 (pyridoxine) before bed can enhance dream vividness and recall. In a single pilot study, Ebben, Lequerica, and Spielman (2002) found that vitamin B6 had a dose-dependent effect of increasing scores on a composite measure of dream vividness, bizarreness, emotionality, and color. The present research replicated this study using a larger and more diverse sample of 100 participants from across Australia. We conducted a randomized, double-blind, placebo-controlled investigation of the effects on dreaming and sleep of ingesting 240 mg vitamin B6 (pyridoxine hydrochloride) before bed for five consecutive days...
January 1, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29659156/mosaic-patterns-of-b-vitamin-synthesis-and-utilization-in-a-natural-marine-microbial-community
#18
Laura Gómez-Consarnau, Rohan Sachdeva, Scott M Gifford, Lynda S Cutter, Jed A Fuhrman, Sergio A Sañudo-Wilhelmy, Mary Ann Moran
Aquatic environments contain large communities of microorganisms whose synergistic interactions mediate the cycling of major and trace nutrients, including vitamins. B-vitamins are essential coenzymes that many organisms cannot synthesize. Thus their exchange among de-novo synthesizers and auxotrophs is expected to play an important role in the microbial consortia and explain some of the temporal and spatial changes observed in diversity. In this study, we analyzed metatranscriptomes of a natural marine coastal microbial community, diel sampled quarterly over one year to try to identify the potential major B-vitamin synthesizers and consumers...
April 16, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29650710/plasma-concentrations-and-dietary-intakes-of-choline-and-betaine-in-association-with-atrial-fibrillation-risk-results-from-3-prospective-cohorts-with-different-health-profiles
#19
Hui Zuo, Gard F T Svingen, Grethe S Tell, Per M Ueland, Stein E Vollset, Eva R Pedersen, Arve Ulvik, Klaus Meyer, Jan E Nordrehaug, Dennis W T Nilsen, Kaare H Bønaa, Ottar Nygård
BACKGROUND: Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac arrhythmias. METHODS AND RESULTS: We evaluated associations of plasma concentrations and dietary intakes of choline and betaine with long-term atrial fibrillation (AF) risk in a community-based cohort, HUSK ([the Hordaland Health Study] n=6949), and validated the findings in 2 patient cohorts: the Western Norway Coronary Angiography Cohort (n=4164) and the NORVIT (Norwegian B-Vitamin) Trial (n=3733)...
April 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29575448/comparison-of-closely-related-uncultivated-coxiella-tick-endosymbiont-population-genomes-reveals-clues-about-the-mechanisms-of-symbiosis
#20
Despina Tsementzi, Juan Castro Gordillo, Mustafa Mahagna, Yuval Gottlieb, Konstantinos T Konstantinidis
Understanding the symbiotic interaction between Coxiella-like endosymbionts (CLE) and their tick hosts is challenging due to lack of isolates and difficulties in tick functional assays. Here we sequenced the metagenome of a CLE population from wild Rhipicephalus sanguineus ticks (CRs) and compared it to the previously published genome of its close relative, CLE of R. turanicus (CRt). The tick hosts are closely related sympatric species, and their two endosymbiont genomes are highly similar with only minor differences in gene content...
March 24, 2018: Environmental Microbiology
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