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Abelardo García de Lorenzo Y Mateos
Following any aggression, the body starts an infl ammatory response, mediated by humoral and cellular factors, intended to limit the process and eventually to heal. In some cases, either due to the intensity or the duration of the aggression or due to an inadequate response of the host, secondary to genetic polymorphisms, malnutrition or other causes, a state of hyper activation of infl ammatory cells is originated, with liberation of immature cells and activation of monocytes and macrophages, which liberate very powerful pro infl ammatory mediators that induce a state of generalized systemic infl ammation...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
K Lian, X Guo, Q Huang, Z Tan, C Xia, R Wang, F Yi, W Li, J Liu, Y Li, S Guo, H Wang, Q Ji, L Tao
Aim: This study was to investigate the change of high-molecula-weight (HMW) adiponectin (APN) isoform, the association between type 2 diabetes mellitus (T2DM) and HMW APN isoform, the variation of Disulfide-bond A oxidoreductase-like protein (DsbA-L), the effect of HMW APN isoform on AMP-dependent protein kinase (AMPK) and endothelial nitric oxide synthase (eNOS) in Chinese T2DM. Method: 169 patients aged at (48.7±9.4) years and 107 healthy control subjects aged at (42.6±7.8) years took part in this study...
October 2016: Experimental and Clinical Endocrinology & Diabetes
Jesús Mingorance, Benito Regueiro, Juan Luis Muñoz-Bellido
La espectrometría de masas (EM) es una técnica de análisis que permite caracterizar muestras midiendo las masas (estrictamente las razones masa-carga) de las moléculas componentes. Cuenta con más de un siglo de historia y evolución tecnológica y a lo largo de los años ha ampliado su alcance desde los isótopos a moléculas pequeñas, moléculas orgánicas más complejas y, en las últimas décadas, macromoléculas (ácidos nucleicos y proteínas). La EM MALDI-TOF (matrix-assisted laser desorption ionization time-of-flight) es una variante que permite el análisis de mezclas complejas de proteínas y que se ha aplicado recientemente a la identificación de microorganismos en cultivo, convirtiéndose en una herramienta rápida y eficaz para el diagnóstico microbiológico que ha conseguido entrar en poco tiempo en la rutina de muchos servicios de microbiología clínica...
June 2016: Enfermedades Infecciosas y Microbiología Clínica
C Balmaceda, M A Espinoza
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Ambar López-Macay, Edgar Josúe Ruiz-Medina, José Luis Ventura-Gallegos, Fabián Arechavaleta-Velasco, Luis Enrique Gómez-Quiroz, Mina Konigsberg-Fainstein, Alejandro Zentella-Dehesa
Inflammation is recognized as part of the etiology of numerous diseases. The interaction among cells of the immunological system with local cells and molecules, such as cytokines and chemokines, allows cellular activation and response amplification. The importance of several physicochemical factors like frictional force, vascular flow, shear stress, and pressure is now recognized because they are known to modulate genetic expression and endothelial activation; however, there are very few studies that recreate such cellular microenvironments...
March 2015: Gaceta Médica de México
Ana Gabriela Conceição-Vertamatti, Luiz Alberto Ferreira Ramos, Ivy Calandreli, Aline Nunes Chiba, Douglas Wagner Franco, Elia Tfouni, Dora Maria Grassi-Kassisse
BACKGROUND: Ruthenium (Ru) tetraamines are being increasingly used as nitric oxide (NO) carriers. In this context, pharmacological studies have become highly relevant to better understand the mechanism of action involved. OBJECTIVE: To evaluate the vascular response of the tetraamines trans-[Ru(II)(NH3)4(Py)(NO)](3+), trans-[Ru(II)(Cl)(NO) (cyclan)](PF6)2, and trans-[Ru(II)(NH3)4(4-acPy)(NO)](3+). METHODS: Aortic rings were contracted with noradrenaline (10(-6) M)...
March 2015: Arquivos Brasileiros de Cardiologia
Chuan-Chih Hsu, Sheng-Hsien Chen, Cheng-Hsien Lin, Ming-Chi Yung
Intolerance to heat exposure is believed to be associated with hypothalamo-pituitary-adrenocortical (HPA) axis impairment [reflected by decreases in blood concentrations of both adrenocorticotrophic-hormone (ACTH) and corticosterone]. The purpose of this study was to determine the effect of human recombinant factor VIIa (rfVIIa) on heat intolerance, HPA axis impairment, and hypothalamic inflammation, ischemic and oxidative damage, and apoptosis in mice under heat stress. Immediately after heat stress (41.2 °C for 1 h), mice were treated with vehicle (1 mL/kg of body weight) or rfVIIa (65-270 µg/kg of body weight) and then returned to room temperature (26 °C)...
October 2014: Apoptosis: An International Journal on Programmed Cell Death
A A Basov, I M Bykov
The effect of nutritional correction (a diet high in foods with antioxidant content) on blood parameters in laboratory animals with metabolic disorders associated with oxidative stress has been studied. In experimental models of laboratory animals (male rabbits weighing 3.5-4.0 kg, n = 40) with purulent septic diseases it has been demonstrated that the use of nutritive correction (replacement of 100 g of the cereal mixture through day on a mixture of cabbage 50 g, carrots 50 g, beet 25 g, apple 25 g, kiwi 10 g and garnet 10 g per 1 rabbit) is not inferior to its efficiency of glutathione use (2 g per day)...
2013: Voprosy Pitaniia
N G Bakhshiev, M B Kiselev
The influence of selective nonspecific solvation on the fluorescence spectra of three substitutedN-methylphthalimides in a binary solvent system consisting of a nonpolar (n-heptane) and a polar (pyridine) component has been studied under conditions close to dielectric saturation. The substantially nonlinearity of the effect is confirmation that the spectral shifts of fluorescence bands depend on the number of polar solvent molecules involved in solvating the dye molecule. The measured fluorescence spectral shifts determined by substituting one nonpolar solvent molecula with a polar one in the proximity of the dye molecule agree quantitatively with the forecasts of the previously proposed semiempirical theory which describes this nonlinear solvation phenomenon...
September 1991: Journal of Fluorescence
Beatriz Suárez-Álvarez, Antonio López-Vázquez, Carlos López-Larrea
Hematopoietic stem cells (HSC) are a population of precursor cells that posses the capacity for self-renewal and multilineage differentiation. In the bone marrow (BM), HSCs warrant blood cell homeostasis, but at the same time a stable pool of functional cells must be constantly maintained. For this, HSCs constitute a model in which subpopulations of quiescent and active adult stem cells co-exist in the same tissue, in specific microenvironment called stem-cell "niches." These microenvironments keep the stem cells at quiescent (osteoblastic niche) for its self-renewal and activate the stem cells (vascular niche) for proliferation and/or injury repair, maintaining a dynamic balance between self-renewal and differentiation...
2012: Advances in Experimental Medicine and Biology
M Longeri, M Polli, W Ponti, M Zanotti
From a sample of 119 Friesian calves, serologically typed for BoLA class I, 47 subjects were chosen expressing 9 different MHC types (A6, A6.9, A10, A11, A14, A15, A30, W16, M103) with the same age and reared in the same farm conditions. The animals were s.c. injected with a water in oil suspension of killed M. bovis and the treatment was repeated two days later. Before the treatment and 21 days later, calves were bled and on PBM (peripheral blood mononuclear leucocytes) were performed the following tests: 1...
January 12, 1993: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
O E Osadchiĭ
The review coveres the features of neurotensin receptor, functional role ot its structural elements, nature of conjugation with effectoral cell systems, and mechanisms of receptor decensitization developing as results of prolonged effect of agonist. The author provides pharmacological description of neurotensin antagonists and special features of three subtypes of its receptors. The author reviews the research results establishing a correlation between structural modification of various section of neurotensin molecula and manifestations of its physiological activity...
April 2006: Uspekhi Fiziologicheskikh Nauk
Zsolt Szabo, Jinsong Xia, William B Mathews, Phillip R Brown
Positron emission tomography (PET) is perfectly suited for quantitative imaging of the kidneys, and the recent improvements in detector technology, computer hardware, and image processing software add to its appeal. Multiple positron emitting radioisotopes can be used for renal imaging. Some, including carbon-11, nitrogen-13, and oxygen-15, can be used at institutions with an on-site cyclotron. Other radioisotopes that may be even more useful in a clinical setting are those that either can be obtained from radionuclide generators (rubidium-82, copper-62) or have a sufficiently long half-life for transportation (fluorine-18)...
January 2006: Seminars in Nuclear Medicine
S V Suchkov, A G Gabibov
The last decade of the 20th century was marked by appearance of a new field at the interfaces between modern immunology, biochemistry, molecular biology, and pathology. The name of this field, abzymology, descends from the terms "antibody" and "enzymes". The new direction is concerned with obtaining and study of abzymes, catalytic antibodies. This new class of biocatalyzers may be obtained artificially, by immunization of animals with transition state analogs, or by induction of anti-idiotypic antibodies to enzymes...
2005: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Tracey L Graham, Claudette Mookherjee, Keith E Suckling, Colin N A Palmer, Lisa Patel
Several lines of evidence suggest a biological role for peroxisome proliferator-activated receptor (PPARdelta) in the pathogenesis of atherosclerosis. Administration of synthetic PPARdelta agonists to obese rhesus monkeys elevates serum high-density lipoprotein (HDL) cholesterol as a result of increased reverse cholesterol transport whilst in vitro studies have suggested a role for PPARdelta in lipid uptake into macrophages. Recent studies have found that PPARdelta depletion from macrophages in LDL receptor (LDLR(-/-)) mice decreases lesion area via modulation of the inflammatory status of the macrophage, an effect also seen on pharmacological activation of PPARdelta in vitro...
July 2005: Atherosclerosis
H Zeisler, J C Livingston, C Schatten, C Tempfer, M Knöfler, P Husslein
In a matched pair study, we investigated the serum levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), platelet endothelial cell adhesion moleculae-1 (PECAM-1) and P-selectin in 40 nulliparous patients with pregnancy-induced hypertension (PIH) and in 40 normotensive pregnant controls by using an enzyme-linked immunosorbent assay (ELISA). Multivariate logistic regression models were used to analyze the influence of elevated serum levels of adhesion molecules on the occurrence of PIH and on the association with the severe form of the disease...
August 16, 2001: Wiener Klinische Wochenschrift
M. Gonzalez-Moles, I. Ruiz-Avila, S. Muwaquet-Rodriguez, J. Fernandez-Martinez, I. Bravo, F. Esteban-Ortega
No abstract text is available yet for this article.
January 1997: Medicina Oral
M A Rebelo, N C Araujo
PURPOSE: To divulge information on the chemical composition and physical-chemical features of some mineral waters from Brazilian natural sources that will be of useful protocol investigation and patient advice. METHODS: The survey was based on bottle labels of non-gaseous mineral waters commercially available in the city of Rio de Janeiro. The íon concentration of each mineral was calculated from the salt content. RESULTS: 36 springs were enralled from different states of the country...
July 1999: Revista da Associação Médica Brasileira
A Hrívó, I Péter, B Bánkúti, G Péley, F Baska, I Besznyák
Amyloid goitre is at an extremely rare occurrence. Authors review the origin of disease and its symptoms, diagnostic and therapeutic tools. The disease may be due to either primary or secondary systemic or local amyloidosis. Diagnosis may be made even before surgery on anamnestic data, on very rapid growth of thyroid glands, on diffuse appearance, on other symptoms of systemic amyloidosis, on findings of iconographic procedures and on detection of amyloid in aspirates. Final diagnosis is based on histology...
March 21, 1999: Orvosi Hetilap
A N Noskov, T B Kravchenko, V P Noskova
Three functional domains were revealed in the molecule of the lethal factor of B. anthracis. They are located in the linear structure of the molecula as follows: the associative domain occupies the area from Lys39 to Met242, the stabilizing domain from Leu517 to Lys614, and the effector domain still further to the COOH-terminal Lys mino acid.
July 1996: Molekuliarnaia Genetika, Mikrobiologiia i Virusologiia
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