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troponin I heart failure

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https://www.readbyqxmd.com/read/29775410/apelin-and-apj-orchestrate-complex-tissue-specific-control-of-cardiomyocyte-hypertrophy-and-contractility-in-the-hypertrophy-heart-failure-transition
#1
Victoria Nicole Parikh, Jing Liu, Ching Shang, Christopher Woods, Alex Chia Yu Chang, Mingming Zhao, David N Charo, Zachary Grunwald, Yong Huang, Kinya Seo, Philip S Tsao, Daniel Bernstein, Pilar Ruiz-Lozano, Thomas Quertermous, Euan A Ashley
The G protein coupled receptor APJ is a promising therapeutic target for heart failure. Constitutive deletion of APJ in the mouse is protective against the hypertrophy-heart failure transition via elimination of ligand-independent, β-arrestin dependent stretch transduction. However, the cellular origin of this stretch transduction and the details of its interaction with apelin signaling remain unknown. We generated mice with conditional elimination of APJ in the endothelium (APJendo-/- ) and myocardium (APJmyo-/- )...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29737180/copeptin-to-rule-out-myocardial-infarction-in-blacks-versus-caucasians
#2
Neil Beri, Lori B Daniels, Allan Jaffe, Christian Mueller, Inder Anand, W Frank Peacock, Judd E Hollander, Christopher DeFilippi, Donald Schreiber, James McCord, Alexander T Limkakeng, Alan H B Wu, Fred S Apple, Deborah B Diercks, John T Nagurney, Richard M Nowak, Chad M Cannon, Paul Clopton, Sean-Xavier Neath, Robert H Christenson, Christopher Hogan, Gary Vilke, Alan Maisel
BACKGROUND: Copeptin in combination with troponin has been shown to have incremental value for the early rule-out of myocardial infarction, but its performance in Black patients specifically has never been examined. In light of a potential for wider use, data on copeptin in different relevant cohorts are needed. This is the first study to determine whether copeptin is equally effective at ruling out myocardial infarction in Black and Caucasian races. METHODS: This analysis of the CHOPIN trial included 792 Black and 1075 Caucasian patients who presented to the emergency department with chest pain and had troponin-I and copeptin levels drawn...
May 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29731073/pretransplantation-cystatin-c-but-not-creatinine-predicts-30-day-cardiovascular-events-and-mortality-in-liver-transplant-recipients-with-normal-serum-creatinine-levels
#3
H-M Kwon, Y-J Moon, K-W Jung, I-G Jun, J-G Song, G-S Hwang
BACKGROUND: The connection between renal dysfunction and cardiovascular dysfunction has been consistently shown. In patients with liver cirrhosis, renal dysfunction shows a tight correlation with prognosis after liver transplantation (LT); therefore, precise renal assessment is mandatory. Cystatin C, a sensitive biomarker for assessing renal function, has shown superiority in detecting mild renal dysfunction compared to classical biomarker creatinine. In this study, we aimed to compare cystatin C and creatinine in predicting 30-day major cardiovascular events (MACE) and all-cause mortality in LT recipients with normal serum creatinine levels...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29730195/transient-myocardial-thickening-in-a-bartonella-henselae-positive-cat
#4
J L Joseph, E M Oxford, R A Santilli
A 3-year-old castrated male domestic shorthair presented to the Cornell University Hospital for Animals for acute onset respiratory distress. Thoracic radiographs, echocardiogram, and electrocardiogram (ECG) revealed left-sided congestive heart failure, myocardial thickening with left atrial dilation, and sinus rhythm conducted with a left bundle branch block, respectively. Cardiac troponin I was elevated and continued to increase over 36 h (1.9 ng/mL, 3.1 ng/mL, and 3.5 ng/mL, sequentially every 12 h)...
May 2, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29721849/sunitinib-does-not-acutely-alter-left-ventricular-systolic-function-but-induces-diastolic-dysfunction
#5
Takeshi Wada, Kentaro Ando, Atsuhiko T Naito, Yuji Nakamura, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Xin Cao, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Yuji Nakazato, Atsushi Sugiyama
PURPOSE: Cancer chemotherapies have improved the prognosis of cancer patients in recent years; however, their side effects on the cardiovascular systems have emerged as a major concern in the field of both cardiology and oncology. In particular, multi-targeted tyrosine kinase inhibitors are known to induce various types of cardiovascular adverse events including hypertension, QT-interval prolongation and heart failure, but their underlying mechanisms remain elusive. To explore how to better predict such drug-induced cardiovascular adverse events, we assessed the electropharmacological effects of sunitinib using the halothane-anesthetized dogs (n = 5), while plasma concentrations of cardiac enzymes including aspartate aminotransferase, lactate dehydrogenase, creatinine kinase and cardiac troponin I  were measured...
May 2, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29721000/association-between-preoperative-high-sensitive-troponin-i-levels-and-cardiovascular-events-after-hip-fracture-surgery-in-the-elderly
#6
Bum Sung Kim, Tae-Hoon Kim, Jeong-Hwan Oh, Chang Hee Kwon, Sung Hea Kim, Hyun-Joong Kim, Heung Kon Hwang, Sang-Man Chung
Objective: Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery (HFS). We used high sensitive troponin I (hs-TnI) assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events (MACE) in elderly hip fracture patients. Method: From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry...
March 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29713851/assessment-of-complementary-treatment-with-yiqi-fumai-lyophilized-injection-on-acute-decompensated-ischemic-heart-failure-act-adihf-rationale-and-design-of-a-multicenter-randomized-controlled-trial
#7
Xianliang Wang, Zhiqiang Zhao, Yazhu Hou, E Tang, Guoyuan Zhao, Shuai Wang, Yingfei Bi, Chengliang Zhong, Ming Ren, Junhua Zhang, Jingyuan Mao, Boli Zhang
BACKGROUND: Heart failure (HF) is the end stage of many heart diseases, and ischemic heart disease (IHD) is the primary cause. Yiqi Fumai lyophilized injection, a contemporary Chinese medicine preparation, widely used in the treatment of IHF patients, shows clinical efficacy on improving symptoms and cardiac function, but the quality of the current literature does not address multiple important issues. This article describes a protocol for assessment of complementary treatment with Yiqi Fumai lyophilized injection in acute decompensated IHD...
April 30, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29710336/association-of-fibroblast-growth-factor-23-with-recurrent-cardiovascular-events-in-patients-after-an-acute-coronary-syndrome-a-secondary-analysis-of-a-randomized-clinical-trial
#8
Brian A Bergmark, Jacob A Udell, David A Morrow, Christopher P Cannon, Dylan L Steen, Petr Jarolim, Andrzej Budaj, Christian Hamm, Jianping Guo, KyungAh Im, Julia F Kuder, Eugene Braunwald, Marc S Sabatine, Michelle L O'Donoghue
Importance: Elevated fibroblast growth factor 23 (FGF-23) concentrations are associated with myocardial fibrosis and renin-angiotensin system upregulation, potentially providing prognostic information distinct from standard cardiovascular (CV) biomarkers. Objective: To evaluate the association of FGF-23 with recurrent CV events in patients after an acute coronary syndrome (ACS). Design, Setting, and Participants: C-terminal FGF-23 was measured in plasma samples using an established enzyme-linked immunosorbent assay system for 4947 patients within 30 days of ACS (median, 14 days) and with 1 additional CV risk factor in the Stabilization of Plaques Using Darapladib-Thrombolysis in Myocardial Infarction 52 (SOLID-TIMI 52) trial of the lipoprotein-associated phospholipase A2 inhibitor darapladib vs placebo performed from December 1, 2009, to April 24, 2014 (median follow-up, 2...
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29710196/long-term-outcomes-of-pediatric-onset-hypertrophic-cardiomyopathy-and-age-specific-risk-factors-for-lethal-arrhythmic-events
#9
Niccolò Maurizi, Silvia Passantino, Gaia Spaziani, Francesca Girolami, Anna Arretini, Mattia Targetti, Iva Pollini, Alessia Tomberli, Silvia Pradella, Giovanni Battista Calabri, Veronica Vinattieri, Bruno Bertaccini, Ornella Leone, Luciano De Simone, Claudio Rapezzi, Niccolò Marchionni, Franco Cecchi, Silvia Favilli, Iacopo Olivotto
Importance: Predictors of lethal arrhythmic events (LAEs) after a pediatric diagnosis of hypertrophic cardiomyopathy (HCM) are unresolved. Existing algorithms for risk stratification are limited to patients older than 16 years because of a lack of data on younger individuals. Objective: To describe the long-term outcome of pediatric-onset HCM and identify age-specific arrhythmic risk factors. Design, Setting, and Participants: This study assessed patients with pediatric-onset hypertrophic cardiomyopathy diagnosed from 1974 to 2016 in 2 national referral centers for cardiomyopathies in Florence, Italy...
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29706818/multiple-admissions-to-the-coronary-care-unit-due-to-falsely-elevated-cardiac-troponin
#10
Mohamed Ayan, Zaid Gheith, Aneesha Ananthula, Mohsin Salih, Srikanth Vallurupalli, Jawahar L Mehta
The measurement of cardiac troponin, released from injured cardiomyocytes, is of paramount importance in the diagnosis of acute myocardial infarction. Elevated troponin can be encountered, however, in patients with cardiomyopathy, significant cardiac arrhythmias, vasculitis, right-sided heart strain, critical systemic illnesses, stroke, drug toxicity (such as Adriamycin), poisons (such as snake venoms), renal failure, seizure, and rhabdomyolysis. If the clinical picture is not consistent with any of these causes, a false-positive result should be considered...
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29660794/diagnostic-utility-of-cardiac-troponin-i-in-cats-with-hypertrophic-cardiomyopathy
#11
Yasutomo Hori, Masayuki Iguchi, Yasuhiro Heishima, Yohei Yamashita, Kensuke Nakamura, Atsushi Hirakawa, Akihito Kitade, Toshiki Ibaragi, Michio Katagi, Tamotsu Sawada, Masashi Yuki, Nobuyuki Kanno, Haruki Inaba, Noriko Isayama, Hideyuki Onodera, Naoki Iwasa, Mikio Kino, Mikihiro Narukawa, Syuhei Uchida
BACKGROUND: Cardiac troponin I (cTnI) is useful for assessing hypertrophic cardiomyopathy (HCM) in cats. OBJECTIVE: To measure plasma cTnI concentrations in healthy cats and evaluate the clinical utility of cTnI in determining the severity of HCM. ANIMALS: Clinically healthy cats (n = 88) and cats with HCM (n = 93). METHODS: Multicenter prospective study. Cats with HCM, including hypertrophic obstructive cardiomyopathy at various stages, were diagnosed using echocardiography...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29622976/patients-with-non-obstructive-coronary-artery-disease-admitted-with-acute-myocardial-infarction-carry-a-better-outcome-compared-to-those-with-obstructive-coronary-artery-disease
#12
Yasser Yazied Abdelmonem, Adel Abdelgawad Bakr, Hossam Ghanem El-Hossary, Mohammed Mahmoud Abdel Ghany
Background: The characterization of patients who have acute myocardial infarction (AMI) and insignificant coronary stenosis is unclear. Aim: The present study aimed to investigate the clinical profile, in-hospital and 3-month outcome of AMI patients with insignificant coronary stenosis in comparison with those with significant disease. Methods: This prospective observational study included 200 consecutive patients admitted with AMI. Group I (100 patients) included patients with insignificant CAD (all lesions <50% stenosis)...
September 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29611320/high-fibroblast-growth-factor-23-concentrations-in-experimental-renal-failure-impair-calcium-handling-in-cardiomyocytes
#13
Melissa Verkaik, Maarten Oranje, Desiree Abdurrachim, Max Goebel, Zeineb Gam, Jeanine J Prompers, Michiel Helmes, Pieter M Ter Wee, Jolanda van der Velden, Diederik W Kuster, Marc G Vervloet, Etto C Eringa
The overwhelming majority of patients with chronic kidney disease (CKD) die prematurely before reaching end-stage renal disease, mainly due to cardiovascular causes, of which heart failure is the predominant clinical presentation. We hypothesized that CKD-induced increases of plasma FGF23 impair cardiac diastolic and systolic function. To test this, mice were subjected to 5/6 nephrectomy (5/6Nx) or were injected with FGF23 for seven consecutive days. Six weeks after surgery, plasma FGF23 was higher in 5/6Nx mice compared to sham mice (720 ± 31 vs...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29581714/congenital-left-ventricular-aneurysms-and-diverticula-an-entity-in-search-of-an-identity
#14
REVIEW
Marc-Alexander Ohlow
Congenital left ventricular aneurysm or diverticulum are rare cardiac malformations described in 809 cases since the first description in 1816, being associated with other cardiac, vascular or thoraco-abdominal abnormalities in about 70%. It appears to be a developmental anomaly, starting in the 4th embryonic week. In an experimental study, targeted knockdown of cardiac troponin T in the chick was performed at day 3, after the heart tube has formed. Morpholino treatment of gene TNNT2 at this stage led to the development of left ventricular diverticula (LVD) in the primitive left ventricular wall...
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29580633/relation-of-testosterone-levels-to-mortality-in-men-with-heart-failure
#15
Akiomi Yoshihisa, Satoshi Suzuki, Yu Sato, Yuki Kanno, Satoshi Abe, Makiko Miyata, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
We aimed to investigate the impact of testosterone on the prognosis of heart failure (HF), as well as the underlying cardiac function, cardiac damage, and exercise capacity. We analyzed consecutive 618 men with HF (age 65.9 years). These patients were divided into quartiles based on their serum levels of total testosterone (TT): first (TT > 631 ng/dl, n = 154), second (462 < TT ≤ 631 ng/dl, n = 155), third (300 < TT ≤ 462 ng/dl, n = 156), and fourth (TT ≤ 300 ng/dl, n = 153) quartiles...
March 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29580629/rates-of-echocardiography-coronary-angiography-and-coronary-intervention-associated-with-troponin-testing-in-hospitalized-patients
#16
Gibbs Wilson, Kevin Kurian, Syed Zamin, Jonathan Urbanczyk, Travis Haneke, Cameron Simonsen, Sachin Mehta, Mitta Suresh, Jeffrey Michel
Diagnosis of acute myocardial infarction (AMI) often depends on detection of cardiac troponin elevation >99th percentile. However, troponin elevation is commonly found in patients without AMI. We have previously reported an association between troponin elevation and rates of electrocardiogram (ECG), echocardiography (ECHO), and coronary angiography (CAG) in patients with a primary diagnosis of sepsis. We hypothesized that elevated troponin might be associated with greater use of ECHO and CAG in primary diagnoses other than sepsis and that this correlation might also include percutaneous coronary intervention (PCI)...
March 2, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29561151/4-6-diaminopyrimidines-as-highly-preferred-troponin-i-interacting-kinase-tnni3k-inhibitors
#17
Joanne Philp, Brian G Lawhorn, Alan P Graves, Lisa Shewchuk, Katrina L Rivera, Larry J Jolivette, Dennis A Holt, Gregory J Gatto, Lara S Kallander
Structure-guided progression of a purine-derived series of TNNI3K inhibitors directed design efforts that produced a novel series of 4,6-diaminopyrimidine inhibitors, an emerging kinase binding motif. Herein, we report a detailed understanding of the intrinsic conformational preferences of the scaffold, which impart high specificity for TNNI3K. Further manipulation of the template based on the conformational analysis and additional structure-activity relationship studies provided enhancements in kinase selectivity and pharmacokinetics that furnished an advanced series of potent inhibitors...
March 21, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29554376/high-sensitivity-cardiac-troponin-i-is-a-biomarker-for-occult-coronary-plaque-burden-and-cardiovascular-events-in-patients-with-rheumatoid-arthritis
#18
George A Karpouzas, Joel Estis, Panteha Rezaeian, John Todd, Matthew J Budoff
Objectives: Patients with RA display greater occult coronary atherosclerosis burden and experience higher cardiovascular morbidity and mortality compared with controls. We here explored whether pro-inflammatory cytokines and high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, correlated with plaque burden and cardiovascular events (CVEs) in RA. Methods: We evaluated 150 patients with 64-slice coronary CT angiography. Coronary artery calcium, number of segments with plaque (segment involvement score), stenotic severity and plaque burden were assessed...
March 14, 2018: Rheumatology
https://www.readbyqxmd.com/read/29523179/a-young-female-presenting-with-heart-failure-secondary-to-eosinophilic-myocarditis-a-case-report-and-review-of-the-literature
#19
Dissanayake Mudiyanselage Priyantha Udaya Kumara Ralapanawa, Kulatunga Wijekoon Mudiyanselage Pramitha Prabhashini Kumarihamy, Miriyalini Sundararajah, Widana Arachchilage Thilak Ananda Jayalath
BACKGROUND: Eosinophilic myocarditis is one of the fatal complications of idiopathic hypereosinophilic syndromes. Given the rarity of this form of myocarditis, it is often under-recognized. We describe a young girl who presented with features of heart failure. To our knowledge, this is the first reported case of eosinophilic myocarditis in a young Sri Lankan female. CASE PRESENTATION: A previously healthy 21 year old Sri Lankan female admitted with shortness of breath for 1 week duration with associated low grade fever and profuse sweating...
March 9, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29516192/randomized-controlled-trial-of-remote-ischaemic-conditioning-in-st-elevation-myocardial-infarction-as-adjuvant-to-primary-angioplasty-ric-stemi
#20
António Gaspar, André P Lourenço, Miguel Álvares Pereira, Pedro Azevedo, Roberto Roncon-Albuquerque, Jorge Marques, Adelino F Leite-Moreira
To test whether remote ischaemic conditioning (RIC) as adjuvant to standard of care (SOC) would prevent progression towards heart failure (HF) after ST-elevation myocardial infarction (STEMI). Single-centre parallel 1:1 randomized trial (computerized block-randomization, concealed allocation) to assess superiority of RIC (3 cycles of intermittent 5 min lower limb ischaemia) over SOC in consecutive STEMI patients (NCT02313961, clinical trials.gov). From 258 patients randomized to RIC or SOC, 9 and 4% were excluded because of unconfirmed diagnosis and previously unrecognized exclusion criteria, respectively...
March 7, 2018: Basic Research in Cardiology
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