keyword
https://read.qxmd.com/read/38221123/revision-of-brazilian-species-of-aleochara-gravenhorst-of-the-subgenus-xenochara-mulsant-rey-coleoptera-staphylinidae-aleocharinae
#21
JOURNAL ARTICLE
Bruna Caroline Buss, Edilson Caron
Aleochara species occur in fly-infested habitats. The larvae feed on the pupae of cyclorraphous Diptera. In Brazil, four subgenera and approximately 30 species have been found. This study provides a taxonomic revision of the Brazilian species of the subgenus Xenochara. Eight species are recognized: A. (X.) puberula Klug, 1833, A. (X.) verberans Erichson, 1839, A. (X.) simulatrix Sharp, 1883, A. (X.) taeniata Erichson, 1839, A. (X.) capitinigra sp. nov., A. (X.) repetita Sharp, 1887, A. (X.) lapidicola (Sahlberg, 1844) and A...
August 17, 2023: Zootaxa
https://read.qxmd.com/read/38221081/review-of-chalcovietnamicus-marusik-1991-with-description-of-four-new-species-araneae-salticidae-euophryini
#22
JOURNAL ARTICLE
Kun Yu, Quang Duy Hoang, Wayne P Maddison, Junxia Zhang
The euophryine genus Chalcovietnamicus Marusik, 1991, a member of the Laufeia group of genera, is reviewed, and four new species from southern China and Southeast Asia are described with both sexes: Chalcovietnamicus logunovi Yu, Maddison & Zhang, sp. nov., C. marusiki Yu, Maddison & Zhang, sp. nov., C. terbakar Yu, Maddison & Zhang, sp. nov. and C. weihangi Yu & Zhang, sp. nov.. The monotypic genus Junxattus Prszyski & Deeleman-Reinhold, 2012 syn. nov. is considered as a junior synonym of Chalcovietnamicus Marusik, 1991, and Parvattus Zhang & Maddison, 2012 is revalidated and removed from synonymy with Chalcovietnamicus Marusik, 1991...
August 24, 2023: Zootaxa
https://read.qxmd.com/read/38178069/reliability-and-validity-of-the-patient-experiences-questionnaire-for-interdisciplinary-treatment-for-substance-dependence-continuous-electronic-measurement-peq-itsd-cem
#23
JOURNAL ARTICLE
Hilde Hestad Iversen, Mona Haugum, Lina Harvold Ellingsen-Dalskau, Oyvind Bjertnaes
BACKGROUND: Inpatient experiences with interdisciplinary treatment for substance dependence and mental health care are measured using continuous electronic measurements in Norway. Major changes in data collection from cross-sectional surveys to continuous measurements necessitated the revalidation of the instrument. The main purpose of the present study was to determine the psychometric properties of the Patient Experiences Questionnaire for Interdisciplinary Treatment for Substance Dependence - Continuous Electronic Measurement (PEQ-ITSD - CEM)...
January 4, 2024: BMC Health Services Research
https://read.qxmd.com/read/38164072/the-correlation-between-albumin-corrected-anion-gap-and-prognosis-in-patients-with-acute-myocardial-infarction
#24
JOURNAL ARTICLE
Haiying Sheng, Jianhong Lu, Lei Zhong, Beiping Hu, Xu Sun, Huifeng Dong
AIMS: Acute myocardial infarction (AMI) is a cardiovascular disease with high morbidity and mortality. We collected patients with AMI from the Medical Information Mart for Intensive Care IV (v2.0) database and explored the association between serum albumin-corrected anion gap (ACAG) level and mortality in patients with AMI. METHODS AND RESULTS: Data of adult patients with AMI were collected. According to the 360 day prognosis, patients were divided into survival and non-survival groups...
January 2, 2024: ESC Heart Failure
https://read.qxmd.com/read/38162201/improving-international-medical-graduates-understanding-of-the-uk-appraisal-system-an-interventional-study
#25
JOURNAL ARTICLE
Priyanka Nageswaran, Pratheeshaa Nageswaran, Kantappa Gajanan
International medical graduates (IMGs) face countless challenges when migrating to a new healthcare system, of which understanding the UK appraisal and revalidation system is one. We investigated whether provision of educational material on appraisals would improve IMGs' confidence in their understanding of the UK appraisal system. A prospective pre-post interventional study aimed at IMGs was carried out between 25 February 2022 and 9 March 2022. A mixed-methods survey was undertaken pre (n=519) and post (n=63) intervention...
November 2023: Future Healthcare Journal
https://read.qxmd.com/read/38145916/should-we-correct-hypospadias-during-childhood-decision-regret-and-quality-of-life-assessment-draqula-study
#26
JOURNAL ARTICLE
Johannes Wirmer, Mohamed Fawzy, Michael Sennert, Ahmed T Hadidi
AIM OF THE WORK: To evaluate patient's satisfaction, Decision Regret And QUality of Life Assessment (DRAQULA) among adolescents (older than 15 years) and adults after hypospadias surgery in childhood. PATIENTS AND METHODS: 234 Patients operated on hypospadias as children in our center and their parents were contacted after they reached the age of 15 years to complete a questionnaire survey to assess satisfaction with the operative result, the regret with the operative decision and the health related quality of life (HRQOL)...
December 14, 2023: Journal of Pediatric Urology
https://read.qxmd.com/read/38141889/sod3-regulates-flt1-to-affect-bone-metabolism-by-promoting-osteogenesis-and-inhibiting-adipogenesis-through-pi3k-akt-and-mapk-pathways
#27
JOURNAL ARTICLE
Ke Xu, Wenchao Fei, Wenxue Gao, Changxiu Fan, Yinghua Li, Yang Hong, Ran Cui
Osteoporosis is a chronic disease that seriously affects the quality of life and longevity of the elderly, so exploring the mechanism of osteoporosis is crucial for drug development and treatment. Bone marrow mesenchymal stem cells are stem cells with multiple differentiation potentials in bone marrow, and changing their differentiation direction can change bone mass. As an extracellular superoxide dismutase, Superoxide Dismutase 3 (SOD3) has been proved to play an important role in multiple organs, but the detailed mechanism of action in bone metabolism is still unclear...
December 21, 2023: Free Radical Biology & Medicine
https://read.qxmd.com/read/38117459/evaluation-of-age-related-changes-in-teneligliptin-pharmacokinetics-in-japanese-and-european-descent-subjects-using-a-physiologically-based-pharmacokinetic-model
#28
JOURNAL ARTICLE
Hiroaki Iijima, Hidetoshi Shimizu, Kazumi Mori-Anai, Atsuhiro Kawaguchi, Yoji Mochida, Toshimasa Yamauchi, Takashi Kadowaki
INTRODUCTION: Drugs often show differing pharmacokinetic (PK) profiles, such as higher plasma concentrations, in older people than in younger people owing to age-related decreases in physiological functions. However, it is difficult to evaluate the PK in older populations. Therefore, we simulated the plasma age-related changes in the PK of teneligliptin, a dipeptidyl peptidase-4 inhibitor, using physiologically based PK (PBPK) models. METHODS: The previously developed PBPK model was revalidated by comparison between simulated data and clinical study data that included older subjects (up to 75 years old)...
December 20, 2023: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38084917/integration-of-yeast-episomal-integrative-plasmid-causes-genotypic-and-phenotypic-diversity-and-improved-sesquiterpene-production-in-metabolically-engineered-saccharomyces-cerevisiae
#29
JOURNAL ARTICLE
Bingyin Peng, Sarah J Weintraub, Zeyu Lu, Samuel Evans, Qianyi Shen, Liam McDonnell, Manuel Plan, Thomas Collier, Li Chen Cheah, Lei Ji, Christopher B Howard, Will Anderson, Matt Trau, Geoff Dumsday, Erin L Bredeweg, Eric M Young, Robert Speight, Claudia E Vickers
The variability in phenotypic outcomes among biological replicates in engineered microbial factories presents a captivating mystery. Establishing the association between phenotypic variability and genetic drivers is important to solve this intricate puzzle. We applied a previously developed auxin-inducible depletion of hexokinase 2 as a metabolic engineering strategy for improved nerolidol production in Saccharomyces cerevisiae , and biological replicates exhibit a dichotomy in nerolidol production of either 3...
December 12, 2023: ACS Synthetic Biology
https://read.qxmd.com/read/38074902/%C3%AF-further-notes-on-the-afrotropical-genus-festucula-simon-1901-araneae-salticidae
#30
JOURNAL ARTICLE
Galina N Azarkina, Stefan H Foord
Notes on four Festucula species are provided. One species, F.botswana sp. nov. , is described as new to science (♀, Botswana). The name F.monticola is revalidated and the male of this species is assigned. The female of F.lawrencei is described for the first time. A new record of F.leroyae is provided.
2023: ZooKeys
https://read.qxmd.com/read/38064307/identification-of-potential-drug-molecules-against-fibroblast-growth-factor-receptor-3-fgfr3-by-multi-stage-computational-biophysics-correlate
#31
JOURNAL ARTICLE
Sajjad Ahmad, Taghreed N Almanaa, Saifullah Khan, Salma Mohammed Aljahdali, Yasir Waheed, Mohammad Abdullah Aljasir, Wafa Abdullah I Al-Megrin, Aamir Aziz, Muhammad Ateeq, Fazli Amin, Saeed Ullah Khattak, Samira Sanami
The fibroblast growth factor receptor 3 (FGFR3) is warranted as a promising therapeutic target in bladder cancer as it is described in 75% of papillary bladder tumors. Considering this, the present study was conducted to use different approaches of computer-aided drug discovery (CADD) to identify the best binding compounds against the active pocket of FGFR3. Compared to control pyrimidine derivative, the study identified three promising lead structures; BDC_24037121, BDC_21200852, and BDC_21206757 with binding energy value of -14...
December 8, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38063556/building-consensus-on-the-point-of-care-ultrasound-skills-required-for-effective-healthcare-service-delivery-at-district-hospitals-in-south-africa-a-delphi-study
#32
JOURNAL ARTICLE
Pierre-Andre Mans, Parimalaranie Yogeswaran, Oladele Vincent Adeniyi
BACKGROUND: Despite the widespread availability of ultrasound machines in South African district hospitals, there are no guidelines on the competency in point-of-care ultrasound (POCUS) use required by generalist doctors in this setting. This study aimed to define the required POCUS competencies by means of consensus via the Delphi method. METHODS: An online Delphi process was initiated in June 2022, using the existing American Academy of Family Physicians' ultrasound curriculum (84 skillsets) as the starting questionnaire...
November 30, 2023: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38059263/temperature-shapes-language-sonority-revalidation-from-a-large-dataset
#33
JOURNAL ARTICLE
Tianheng Wang, Søren Wichmann, Quansheng Xia, Qibin Ran
Multiple factors of the natural environment have been found to impact and mold the phonetic patterns of human speech, among which the potential correlation between sonority and temperature has garnered significant attention. We leverage a large database containing basic vocabularies of 5,293 languages and calculate the average sonority for each language by adopting a universal sonority scale. Our findings confirm a positive correlation between sonority and temperature across macroareas and language families, whereas this relationship cannot be discerned within language families...
December 2023: PNAS Nexus
https://read.qxmd.com/read/38054253/belgian-recommendations-for-analytical-verification-and-validation-of-immunohistochemical-tests-in-laboratories-of-anatomic-pathology
#34
JOURNAL ARTICLE
Hannelien Verbeke, Donald Van Hecke, Caroline Bauraing, Anne Marie Dierick, Orphal Colleye, Ignace Dalle, Kathleen Dewachter, Yves Guiot, Raphael Lequeu, Nancy Vanderheyden, Karen Zwaenepoel, Romaric Croes
Analytical verification and validation of immunohistochemical (IHC) tests and their equipment are common practices for today's anatomic pathology laboratories. Few references or guidelines are available on how this should be performed. The study of Sciensano (the Belgian national competent authority regarding licensing of medical laboratories) performed in 2016, demonstrated a significant interlaboratory variation in validation procedures of IHC tests among Belgian laboratories. These results suggest the unavailability of practical information on the approach to the verification and validation of these tests...
January 1, 2024: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://read.qxmd.com/read/38050898/patients-involvement-in-the-discharge-process-from-hospital-to-home-a-patient-s-journey
#35
JOURNAL ARTICLE
Güven Alarslan, Rosa Mennes, Renate Kieft, Maud Heinen
AIMS: The aims of the study were to gain insight in the transfer process from hospital to homecare or rehabilitation centre from a patient's perspectives and to describe the experienced involvement, information provision and information needs patients. DESIGN: A multiple case study with a phenomenological approach. METHODS: Observations and interviews were employed, between May 2019 and August 2019, to capture the patient's perspectives and experiences on involvement, information provision and needs...
December 5, 2023: Journal of Advanced Nursing
https://read.qxmd.com/read/38028270/assessing-the-effectiveness-of-real-time-online-parent-training-for-parents-of-children-with-diverse-neurodevelopmental-disorders-residing-in-the-community
#36
JOURNAL ARTICLE
Tomohisa Yamanaka, Kengo Yuruki, Yuto Sanabe, Maki Yasutake, Masahiko Inoue
BACKGROUND: Parents residing in the community have children with diverse neurodevelopmental disorders. Thus, developing online parent training that is effective for various types of neurodevelopmental disorders, not just for a single one, is essential. This study investigated the effects of real-time online group parent training developed for parents of children with various neurodevelopmental disorders. METHODS: Twenty-two parents (two males and 20 females) of children with diagnosed or suspected neurodevelopmental disorders participated...
November 2023: Yonago Acta Medica
https://read.qxmd.com/read/38020795/health-staff-s-job-motivation-post-covid-19-pandemic-a-case-study-in-vietnam
#37
JOURNAL ARTICLE
Nguyen Duc Thanh, Pham Quynh Anh, Pham Thi Huyen Chang, Hoang Van Dung, Chu Huyen Xiem, Le Bao Chau
OBJECTIVES: Vietnam has witnessed a severe shortage of qualified staff in the public health sector after the COVID-19 pandemic. Our cross-sectional study aimed to identify job motivation and associated factors among experienced frontline health staff working in public health in order to have preventive measures in the event of future pandemics. METHODS: A cross-sectional study, from March 2022 to November 2022 at a Vietnamese public hospital, on the job motivation and the predicted factors of 381 healthcare workers who participated in the frontlines of the COVID-19 pandemic from 2020 to 2021...
2023: SAGE Open Medicine
https://read.qxmd.com/read/37993937/myrislignan-targets-extracellular-signal-regulated-kinase-erk-and-modulates-mitochondrial-function-to-dampen-osteoclastogenesis-and-ovariectomy-induced-osteoporosis
#38
JOURNAL ARTICLE
Tao Yang, Weiwei Chen, Kai Gan, Chaofeng Wang, Xiaoxiao Xie, Yuangang Su, Haoyu Lian, Jiake Xu, Jinmin Zhao, Qian Liu
BACKGROUND: Activated osteoclasts cause excessive bone resorption, and disrupt bone homeostasis, leading to osteoporosis. The extracellular signal-regulated kinase (ERK) signaling is the classical pathway related to osteoclast differentiation, and mitochondrial reactive oxygen species are closely associated with the differentiation of osteoclasts. Myrislignan (MRL), a natural product derived from nutmeg, has multiple pharmacological activities; however, its therapeutic effect on osteoporosis is unclear...
November 22, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37944334/femoral-metastatic-pathological-fractures-impending-and-actual-fractures-a-patient-survival-study
#39
JOURNAL ARTICLE
Oded Hershkovich, Mojahed Sakhnini, Gal Barkay, Boaz Liberman, Alon Friedlander, Raphael Lotan
INTRODUCTION: The skeleton is a common site for metastases. Prostate, breast, lung, renal and thyroid carcinomas account for 80 % of the original cancers, with the femur being the most affected long bone. With improved oncological treatments, prolonged patient survival leads to an increased prevalence of osseous metastases. This study examines the impact of preventive surgery for impending femoral pathological fracture (IFF), versus treatment of pathological femur fracture (PFF) on patient mortality and morbidity...
December 2023: Surgical Oncology
https://read.qxmd.com/read/37871196/revealing-the-missing-puzzle-piece-of-concentration-in-regulating-zn-electrodeposition
#40
JOURNAL ARTICLE
Zhongxi Zhao, Yi He, Wentao Yu, Wenxu Shang, Yanyi Ma, Peng Tan
Despite achievements in suppressing dendrites and regulating Zn crystal growth, secondary aqueous Zn batteries are still rare in the market. Existing strategies mainly focus on electrode modification and electrolyte optimization, while the essential role of ion concentration in liquid-to-solid electrodeposition is neglected for a long time. Herein, the mechanism of concentration regulation in Zn electrodeposition is investigated in depth by combining electrochemical tests, post hoc characterization, and multiscale simulations...
October 31, 2023: Proceedings of the National Academy of Sciences of the United States of America
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