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https://www.readbyqxmd.com/read/28098833/role-of-electron-driven-proton-transfer-processes-in-the-ultrafast-deactivation-of-photoexcited-anionic-8-oxoguanine-adenine-and-8-oxoguanine-cytosine-base-pairs
#1
Xiuxiu Wu, Tolga N V Karsili, Wolfgang Domcke
It has been reported that 8-oxo-7,8-dihydro-guanosine (8-oxo-G), which is the main product of oxidative damage of DNA, can repair cyclobutane pyrimidine dimer (CPD) lesions when incorporated into DNA or RNA strands in proximity to such lesions. It has therefore been suggested that the 8-oxo-G nucleoside may have been a primordial precursor of present-day flavins in DNA or RNA repair. Because the electron transfer leading to the splitting of a thymine-thymine pair in a CPD lesion occurs in the photoexcited state, a reasonably long excited-state lifetime of 8-oxo-G is required...
January 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098014/pressure-ulcer-prevention
#2
Malgorzata Zdzioch
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The CPD article discussed the importance of preventing pressure ulcers in frail older people. It outlined the risk factors, classification and effects of pressure ulcers, and the methods used to prevent their development.
January 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28094622/cuts-to-cpd-funding-undermine-nursing
#3
Sheila McQueen
It is worrying that for 2016-17, Health Education England's (HEE) funding for continuing professional development has suffered significant cuts of up to 45%, with little discussion about strategic plans for CPD at a national level.
January 4, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28094618/diabetes
#4
Heather Lovitt
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The CPD article provided an overview of diabetes. It outlined the differences between type 1 and type 2 diabetes, and included information about the diagnosis, causes and treatment of the condition.
January 4, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28091673/conformational-and-electronic-effects-on-the-formation-of-anti-cyclobutane-pyrimidine-dimers-in-g-quadruplex-structures
#5
Wook Lee, Spiridoula Matsika
Cyclobutane pyrimidine dimers (CPDs) are the most commonly formed photochemical products when nucleic acids interact with UV radiation. In duplex DNA, the relative inflexible structure allows for only the cis, syn CPD isomer to be formed. G-quadruplex structures, however, have loops that are more flexible and allow for different orientations of the bases to interact. As a result, the highly unusual formation of an anti CPD has been observed in these structures. Due to the close proximity between two opposing loops containing the TTA sequence in two G-quadruplex structures (called "form-3" and "basket"), a high yield of anti CPD formation was expected in these structures...
January 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28075301/revalidation
#6
Linda Thorley
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The article discussed the Nursing and Midwifery Council (NMC) revalidation process, which replaced the post-registration education and practice requirements in April 2016. It stated that nurses and midwives must undertake revalidation every three years to renew their NMC registration.
January 11, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28061864/identification-of-brassinosteroid-genes-in-brachypodium-distachyon
#7
Claudia Corvalán, Sunghwa Choe
BACKGROUND: Brassinosteroids (BRs) are steroidal phytohormones that are involved in diverse physiological processes and affect many important traits, such as plant stature, stress tolerance, leaf angle, fertility, and grain filling. BR signaling and biosynthetic pathways have been studied in various plants, such as the model dicot Arabidopsis thaliana; however, relatively little is known about these pathways in monocots. RESULTS: To characterize BR-related processes in the model grass Brachypodium distachyon, we studied the response of these plants to the specific BR biosynthesis inhibitor, propiconazole (Pcz)...
January 6, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28060924/the-effector-domain-region-of-the-vibrio-vulnificus-martx-toxin-confers-biphasic-epithelial-barrier-disruption-and-is-essential-for-systemic-spread-from-the-intestine
#8
Hannah E Gavin, Nike T Beubier, Karla J F Satchell
Vibrio vulnificus causes highly lethal bacterial infections in which the Multifunctional Autoprocessing Repeats-in-Toxins (MARTX) toxin product of the rtxA1 gene is a key virulence factor. MARTX toxins are secreted proteins up to 5208 amino acids in size. Conserved MARTX N- and C-terminal repeat regions work in concert to form pores in eukaryotic cell membranes, through which the toxin's central region of modular effector domains is translocated. Upon inositol hexakisphosphate-induced activation of the of the MARTX cysteine protease domain (CPD) in the eukaryotic cytosol, effector domains are released from the holotoxin by autoproteolytic activity...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28060126/pediatric-acquired-von-willebrand-syndrome-in-cardiopulmonary-disorders-do-laboratory-abnormalities-predict-bleeding-risk
#9
Saman K Hashmi, Mireya P Velasquez, Donald L Yee, Shiu-Ki Hui, Donald Mahoney, Lakshmi V Srivaths
There are conflicting reports on whether or not laboratory abnormalities in pediatric acquired von Willebrand syndrome (AVWS) predict bleeding manifestations in patients with cardiopulmonary disorders (CPD). We retrospectively reviewed charts of patients with AVWS and CPD (n=16) seen at Texas Children's Hospital from 2003 to 2012. The most common CPD were valve stenoses, ventricular septal defects, and pulmonary hypertension. All patients had loss of high molecular weight multimers. Fifteen (94%) patients presented with bleeding symptoms, with menorrhagia and epistaxis being the most common...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28056928/new-ligation-independent-cloning-vectors-for-expression-of-recombinant-proteins-with-a-self-cleaving-cpd-6xhis-tag
#10
Marco Biancucci, Jazel S Dolores, Jennifer Wong, Sarah Grimshaw, Wayne F Anderson, Karla J F Satchell, Keehwan Kwon
BACKGROUND: Recombinant protein purification is a crucial step for biochemistry and structural biology fields. Rapid robust purification methods utilize various peptide or protein tags fused to the target protein for affinity purification using corresponding matrices and to enhance solubility. However, affinity/solubility-tags often need to be removed in order to conduct functional and structural studies, adding complexities to purification protocols. RESULTS: In this work, the Vibrio cholerae MARTX toxin Cysteine Protease Domain (CPD) was inserted in a ligation-independent cloning (LIC) vector to create a C-terminal 6xHis-tagged inducible autoprocessing enzyme tag, called "the CPD-tag"...
January 5, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28056219/antimicrobial-resistant-escherichia-coli-and-enterococcus-spp-isolated-from-miranda-donkey-equus-asinus-an-old-problem-from-a-new-source-with-a-different-approach
#11
Isabel Carvalho, Rosa Del Campo, Margarida Sousa, Nuno Silva, João Carrola, Catarina Marinho, Tiago Santos, Silvia Carvalho, Miguel Nóvoa, Miguel Quaresma, José Eduardo Pereira, Marta Cobo, Gilberto Igrejas, Patricia Poeta
The Miranda Donkey (Equus asinus) is an endangered asinine from Miranda do Douro region, located in North East of Portugal. We study the antimicrobial resistance (AMR) and virulence genes in Escherichia coli and Enterococcus spp. isolates from these animals. In March 2014, a total of 66 faecal samples were recovered from independent animals. Antibiotic resistance was determined by the disk diffusion method. Carriage of genes codifying for antibiotic resistant and virulent factors was analyzed by polymerase chain reaction (PCR)...
January 5, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28049853/genetic-stability-of-genome-scale-deoptimized-rna-virus-vaccine-candidates-under-selective-pressure
#12
Cyril Le Nouën, Thomas McCarty, Michael Brown, Melissa Laird Smith, Roberto Lleras, Michael A Dolan, Masfique Mehedi, Lijuan Yang, Cindy Luongo, Bo Liang, Shirin Munir, Joshua M DiNapoli, Steffen Mueller, Eckard Wimmer, Peter L Collins, Ursula J Buchholz
Recoding viral genomes by numerous synonymous but suboptimal substitutions provides live attenuated vaccine candidates. These vaccine candidates should have a low risk of deattenuation because of the many changes involved. However, their genetic stability under selective pressure is largely unknown. We evaluated phenotypic reversion of deoptimized human respiratory syncytial virus (RSV) vaccine candidates in the context of strong selective pressure. Codon pair deoptimized (CPD) versions of RSV were attenuated and temperature-sensitive...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28045046/an-allosteric-conduit-facilitates-dynamic-multisite-substrate-recognition-by-the-scf-cdc4-ubiquitin-ligase
#13
Veronika Csizmok, Stephen Orlicky, Jing Cheng, Jianhui Song, Alaji Bah, Neda Delgoshaie, Hong Lin, Tanja Mittag, Frank Sicheri, Hue Sun Chan, Mike Tyers, Julie D Forman-Kay
The ubiquitin ligase SCF(Cdc4) mediates phosphorylation-dependent elimination of numerous substrates by binding one or more Cdc4 phosphodegrons (CPDs). Methyl-based NMR analysis of the Cdc4 WD40 domain demonstrates that Cyclin E, Sic1 and Ash1 degrons have variable effects on the primary Cdc4(WD40) binding pocket. Unexpectedly, a Sic1-derived multi-CPD substrate (pSic1) perturbs methyls around a previously documented allosteric binding site for the chemical inhibitor SCF-I2. NMR cross-saturation experiments confirm direct contact between pSic1 and the allosteric pocket...
January 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/28003982/assessment-of-contrast-sensitivity-loss-after-intrastromal-femtosecond-laser-and-lasik-procedure
#14
Elsa L C Mai, Ie-Bin Lian, David C K Chang
AIM: To assess the loss of contrast sensitivity (CS) function for INTRACOR or intrastromal femtosecond laser presbyopia procedure to conventional LASIK procedures. METHODS: Patients were recruited from a refractive surgery center for either INTRACOR or conventional LASIK. INTRACOR was performed on 8 eyes and LASIK was performed for 40 eyes in an overlapping period. Pre-operative evaluation and post-operative follow up for up to three months was done. Drops of CS in 4 spatial frequency (3 cpd, 6 cpd, 12 cpd and 18 cpd) right before and 3mo after the surgery were compared by Wilcoxon signed ranks test...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003981/phakic-posterior-chamber-intraocular-lens-for-unilateral-high-myopic-amblyopia-in-chinese-pediatric-patients
#15
Jing Zhang, Jin-Rong Li, Zi-Dong Chen, Min-Bin Yu, Ke-Ming Yu
AIM: To assess the outcomes of posterior chamber implantable collamer lens (ICL) implantation in Chinese pediatric patients with unilateral high myopic amblyopia. METHODS: Eleven eyes of 11 amblyopic patients aged 11.02±3.34y underwent ICL (model V4, Staar Surgical Inc.) implantation to treat unilateral anisometropia were studied. Visual acuity, cycloplegic refraction, contrast sensitivity, stereopsis, intraocular pressure (IOP), vaulting, corneal endothelial cell count and complications were evaluated...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003977/combination-of-toric-and-multifocal-intraocular-lens-implantation-in-bilateral-cataract-patients-with-unilateral-astigmatism
#16
Jing-Li Liang, Fang Tian, Hong Zhang, He Teng
AIM: To assess the binocular visual function in bilateral cataract patients with unilateral astigmatism after combined implantations of Toric with multifocal intraocular lens (IOL), and to compare with that of Toric and monofocal IOL implantation. METHODS: All the 30 patients with unilateral astigmatism suffered bilateral cataract were randomly divided into two groups: Toric plus multifocal IOL group and Toric plus monofocal IOL group. Uncorrected and corrected visual acuity at distance (5...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003901/bilateral-anterior-ischaemic-optic-neuropathy-in-a-child-on-continuous-peritoneal-dialysis-case-report-and-literature-review
#17
Abdullah Al-Kaabi, Agha S Haider, Mohammed O Shafeeq, Mohammed A El-Naggari, Ibtisam El-Nour, Anuradha Ganesh
Non-arteritic anterior ischaemic optic neuropathy (NAION) is a serious complication of continuous peritoneal dialysis (CPD) which can lead to poor vision and blindness. We report a five-year-old girl who had undergone a bilateral nephrectomy at the age of one year and was on home CPD. She was referred to the Paediatric Ophthalmology Unit of Sultan Qaboos University Hospital, Muscat, Oman, in 2013 with acute bilateral vision loss, preceded by a three-day history of poor oral intake. At presentation, the patient had severe systemic hypotension...
November 2016: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28003509/the-importance-of-relevant-emotional-arousal-in-the-efficacy-of-pictorial-health-warnings-for-cigarettes
#18
Zhenhao Shi, An-Li Wang, Lydia F Emery, Kaitlin M Sheerin, Daniel Romer
INTRODUCTION: Warning labels for cigarettes proposed by Food and Drug Administration (FDA) were rejected by the courts partly because they were thought to be emotionally evocative but have no educational value. To address this issue, we compared three types of smoking warnings: (1) FDA-proposed warnings with pictures illustrating the smoking hazards; (2) warnings with the same text information paired with equally aversive but smoking-irrelevant images; and (3) text-only warnings. METHODS: Smokers recruited through Amazon's Mechanical Turk were randomly assigned to one of the three conditions...
December 21, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28001911/sustained-professional-development-on-cooperative-learning-impact-on-six-teachers-practices-and-students-learning
#19
Victoria A Goodyear
PURPOSE: It has been argued, extensively and internationally, that sustained school-based continuous professional development (CPD) has the potential to overcome some of the shortcomings of traditional one-off CPD programs. Yet, the evidence base on more effective or less effective forms of CPD is contradictory. The mechanisms by which sustained support should be offered are unclear, and the impacts on teachers' and students' learning are complex and difficult to track. The purpose of this study was to examine the impact of a sustained school-based, tailored, and supported CPD program on teachers' practices and students' learning...
December 21, 2016: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28000658/evaluation-of-left-ventricular-ejection-fractions-in-breast-cancer-patients-undergoing-long-term-trastuzumab-treatment
#20
Yong Sun, Tao Li, Yuanpeng Zhang, Qiwen Zhang
BACKGROUND The aim of this study was to assess the long-term clinical tolerance and cardiac safety during trastuzumab treatment for patients diagnosed as having breast cancer with human epidermal growth factor receptor 2 (HER2) overexpression. MATERIAL AND METHODS A total 105 female cases diagnosed as having breast cancer with high expression of Her2, were treated with trastuzumab (T). All of them underwent electrocardiography monitoring in the process of T treatment. Left ventricular ejection fractions (LVEFs) were estimated using echocardiography before the T treatment and every 3 months...
December 21, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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