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https://www.readbyqxmd.com/read/28816384/intracellular-delivery-of-functional-native-antibodies-under-hypoxic-conditions-by-using-a-biodegradable-silica-nanoquencher
#1
Shao Q Yao, Peiyan Yuan, Hailong Zhang, Linghui Qian, Xin Mao, Shubo Du, Changmin Yu, Bo Peng
Antibodies are important biopharmaceuticals, but almost all antibody-based drugs are limited to targeting antigens located at the cell exterior due to their inability to enter the cell interior. Available methods for intracellular delivery of antibodies have major shortcomings. Herein we report an approach to encapsulate native antibodies in a biodegradable silica nanoquencher (BS-qNP) which could undergo efficient cellular uptake and intracellular degradation to release antibodies under hypoxic conditions...
August 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28816218/continuing-professional-development-of-doctors
#2
Tejinder Singh
After graduating from medical school, all doctors need to undertake some training activities lifelong to maintain, update or develop their knowledge, skills and attitudes towards their professional practice. Continuing professional development (CPD) refers to continuing development of medical and non- medical competencies including professionalism, and interpersonal, managerial and communication skills. There is no single correct way of doing CPD. Most learning in CPD is self-directed and based on one's own learning needs...
March 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28812747/identifying-the-charge-generation-dynamics-in-cs-based-triple-cation-mixed-perovskite-solar-cells
#3
Manuel Salado, Ramesh K Kokal, Laura Calio, Samrana Kazim, Melepurath Deepa, Shahzada Ahmad
Triple cation based perovskite solar cells offer enhanced moisture tolerance and stability compared to mixed perovskites. Slight substitution of methyl ammonium or formamidinium cation by cesium (Cs(+)), was also reported to eliminate halide segregation due to its smaller size. To elucidate the device kinetics and understand the role of the Cs, we undertook different modes of scanning probe microscopy and electrochemical impedance spectroscopy (EIS) experiments. Kelvin probe force microscopy revealed that the incorporation of the Cs cation increases the contact potential difference (CPD), this CPD further increases when Spiro-OMeTAD is used as a hole transport material...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28812504/practising-mindfulness
#4
Irene Gilsenan
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The article examined the use of mindfulness techniques and how by learning to care for themselves, nurses can enhance the care they provide for patients. The concept of mindfulness has had widespread publicity, from meditation courses to adult colouring books, but I wanted to learn how mindfulness can be applied to nursing.
August 16, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28809462/multiple-electronic-and-structural-factors-control-cpd-and-6-4-thymine-thymine-photodimerization-in-dna-duplex
#5
Irene Conti, Lara Martinez Fernandez, Luciana Esposito, Siegfried Hofinger, Artur Nenov, Marco Garavelli, Roberto Improta
The T-T photodimerization paths leading to the formation of cyclobutane pyrimidine dimer (CPD) and 6-4 pyrimidine pyrimidone (64-PP), the two main DNA photolesions, have been resolved for a T-T step in a DNA duplex by two complementary state-of-the art quantum mechanical approaches: QM(CASPT2//CASSCF)/MM and TD-DFT/PCM. Based on the analysis of several different representative structures, we define a new-ensemble of cooperating geometrical and electronic factors (besides the distance between the reacting bonds) ruling T-T photodimerization in DNA...
August 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28802828/photolyase-dynamics-and-electron-transfer-mechanisms-of-dna-repair
#6
REVIEW
Meng Zhang, Lijuan Wang, Dongping Zhong
Photolyase, a flavoenzyme containing flavin adenine dinucleotide (FAD) molecule as a catalytic cofactor, repairs UV-induced DNA damage of cyclobutane pyrimidine dimer (CPD) and pyrimidine-pyrimidone (6-4) photoproduct using blue light. The FAD cofactor, conserved in the whole protein superfamily of photolyase/cryptochromes, adopts a unique folded configuration at the active site that plays a critical functional role in DNA repair. Here, we review our comprehensive characterization of the dynamics of flavin cofactor and its repair photocycles by different classes of photolyases on the most fundamental level...
August 9, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28802017/volatile-composition-and-sensory-profile-of-shiitake-mushrooms-as-affected-by-drying-method
#7
Joanna Politowicz, Krzysztof Lech, Leontina Lipan, Adam Figiel, Ángel A Carbonell-Barrachina
BACKGROUND: One of the best preservation method for long-term storage is drying. In this work, the influence of different drying methods on aroma and sensory profile of shiitake mushroom was evaluated. The drying methods tested were: convective drying (CD), freeze-drying (FD), vacuum-microwave drying (VMD), and a combination of convective pre-drying and vacuum-microwave finish-drying (CPD-VMFD). RESULTS: The volatile composition of fresh and dried shiitake mushrooms was analyzed by SPME, GC-MS and GC-FID, and showed the presence of 71 volatile compounds, most of them present in all dried samples but with quantitative variation...
August 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28801362/trends-in-cigarette-consumption-and-time-to-first-cigarette-on-awakening-from-2002-to-2015-in-the-usa-new-insights-into-the-ongoing-tobacco-epidemic
#8
Renee D Goodwin, Melanie M Wall, Misato Gbedemah, Mei-Chen Hu, Andrea H Weinberger, Sandro Galea, Michael J Zvolensky, Elizabeth Hangley, Deborah S Hasin
OBJECTIVE: The current study estimates trends in the number of cigarettes smoked per day (CPD) and percentage of smokers having their first CPD within 30 min of waking (time to first cigarette (TTFC)<30 min) among smokers from 2002 to 2015 in the USA overall, and adjusting for demographics. Trends in TTFC<30 min were also estimated by varying levels of cigarette consumption. METHODS: Data were drawn from the National Household Survey on Drug Use, an annual nationally representative cross-sectional study of the US population aged 12 and older (n=54 079-58 397 per year)...
August 10, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28797905/evidence-for-the-role-of-bmnpv-bm65-protein-in-the-repair-of-ultraviolet-induced-dna-damage
#9
Qi Tang, Peng Wu, Zhaoyang Hu, Yanhua Yang, Lipeng Qiu, Hanqing Liu, Shanying Zhu, Zhongjian Guo, Hengchuan Xia, Keping Chen, Guohui Li
It is unclear how, or to what extent, baculovirus DNA that has been damaged by ultraviolet (UV) light is repaired during infection and replication. In our previous study, expression of Bombyx mori nucleopolyhedrovirus (BmNPV) ORF Bm65, a homolog of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac79, correlated with decreased inactivation of virus by UV irradiation. In the current study, we accumulated more evidence pointing to a role for Bm65 in repair of UV-induced DNA damage. The localization of Bm65 was studied using enhanced green fluorescent protein (EGFP) fusion constructs expressed in BmN cells transfected with a Bm65 expression plasmid...
August 8, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28795358/psychophysical-measurements-of-luminance-contrast-sensitivity-and-color-discrimination-with-transparent-and-blue-light-filter-intraocular-lenses
#10
Marcelo Fernandes da Costa, Augusto Paranhos Júnior, Claudio Luiz Lottenberg, Leonardo Cunha Castro, Dora Fix Ventura
INTRODUCTION: The purpose of this study was to measure luminance contrast sensitivity and color vision thresholdfs in normal subjects using a blue light filter lens and transparent intraocular lens material. METHODS: Monocular luminance grating contrast sensitivity was measured with Psycho for Windows (version 2.36; Cambridge Research Systems) at 3.0, 6.0, 12.0, 20.0, and 30.0 cycles per degree of visual angle (cpd) in 15 normal subjects (eight female), with a mean age of 21...
August 9, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28793799/undergraduate-dermatology-education-in-canada-a-national-survey
#11
Angela Hu, Ron Vender
BACKGROUND: Canadian dermatology curriculum was reviewed in 1983, 1987, 1996, and 2008. All these surveys highlighted the disproportionately low level of dermatology teaching in relation to the significant amount of skin disease seen by physicians. Since the official adoption and dissemination of the Canadian Professors of Dermatology (CPD) core curriculum and competencies, there has been no assessment of how these changes have influenced dermatology curriculum. OBJECTIVE: This survey gathered information on the current status of undergraduate dermatology education across Canadian medical schools...
August 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28792335/altered-body-image
#12
Rose Gallacher
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The article discussed psychological support for patients with altered body image resulting from illness, injury or disability. These changes may affect appearance or function of the patient's body.
August 9, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28780954/continuing-professional-development-cpd-in-radiography-a%C3%A2-collaborative-european-meta-ethnography-literature-review
#13
REVIEW
A Wareing, C Buissink, D Harper, M Gellert Olesen, M Soto, S Braico, P Van Laer, I Gremion, L Rainford
OBJECTIVES: The aim of the study was to complete a collaborative review of Radiography continuing professional development (CPD) research material to support the production of European Federation of Radiographer Societies (EFRS) CPD recommendations. A meta-ethnography approach to literature review was applied focussing upon commonalities rather than discrepancies between research outcomes. This facilitated exploration of context across the geographical region of Europe with national variations in CPD governance...
September 2017: Radiography
https://www.readbyqxmd.com/read/28780195/calcium-mitochondrial-dysfunction-and-slowing-the-progression-of-parkinson-s-disease
#14
REVIEW
D James Surmeier, Glenda M Halliday, Tanya Simuni
Parkinson's disease is characterized by progressively distributed Lewy pathology and neurodegeneration. The motor symptoms of cPD are unequivocally linked to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Several features of these neurons appear to make them selectively vulnerable to factors thought to cause cPD, like aging, genetic mutations and environmental toxins. Among these features, Ca(2+) entry through Cav1 channels is particularly amenable to pharmacotherapy in early stage cPD patients...
August 2, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28774520/partnering-to-develop-a-continuing-professional-development-program-in-a-low-resource-setting-cambodia
#15
Heather G Mack, Ngy Meng, Tanya Parsons, Gerhard Schlenther, Neil Murray, Richard Hart
OBJECTIVE: To design and implement a continuing professional development (CPD) program for Cambodian ophthalmologists. DESIGN: Partnering (twinning) between the Royal Australian and New Zealand College of Ophthalmologists (RANZCO) and the Cambodian Ophthalmological Society (COS). PARTICIPANTS: Practicing ophthalmologists in Cambodia. METHODS: A conjoint committee comprising 4 ophthalmologists from RANZCO and 3 ophthalmologists from COS was established, supported by a RANZCO administrative team experienced in CPD administration...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28772248/evaluating-the-utility-of-subjective-effects-measures-for-predicting-product-sampling-enrollment-and-retention-in-a-clinical-trial-of-a-smokeless-tobacco-product
#16
Richard J O'Connor, Bruce R Lindgren, Liane M Schneller, Peter G Shields, Dorothy K Hatsukami
INTRODUCTION: Subjective effects of drugs, representing pharmacological and non-pharmacological effects, have been shown to be associated with future use and abuse. This also is the case for tobacco products and so measuring subjective effects, such as liking, satisfaction, and aversion, is crucial to gaining an understanding of consumer perception leading to increased use. This study examined the predictive validity of subjective drug and product effects with respect to product adoption...
July 14, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28767542/factors-influencing-physicians-selection-of-continuous-professional-development-activities-a-cross-specialty-national-survey
#17
David A Cook, David W Price, Christopher M Wittich, Colin P West, Morris J Blachman
INTRODUCTION: We sought to understand what influences physicians' decisions about participation in continuous professional development (CPD) activities, and how often physicians engage in specific CPD activities. METHODS: From September 2015 to April 2016, we administered a survey to 4648 randomly sampled licensed US physicians. Survey items addressed perceived barriers to CPD, factors that might influence participation in four prototypical CPD activities (reading an article, or completing a local activity, online course, or far-away course), and frequency of CPD engagement...
July 27, 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28766423/implantable-cardioverter-defibrillators
#18
Helen Ballantyne
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The article discussed the factors associated with health-related quality of life in patients with an implantable cardioverter defibrillator (ICD). In my practice, I discuss ICDs regularly with patients who have these devices and with those who may require them imminently. The article provided information that will enable me to ensure these discussions are person-centred.
August 2, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28765405/continuing-professional-development-and-irish-hospital-doctors-a-survey-of-current-use-and-future-needs
#19
Bridget Maher, Adnan Faruqui, Mary Horgan, Colm Bergin, Colm O Tuathaigh, Deirdre Bennett
Doctors rate clinical relevance and applicability as the most important determinants of continuing professional development (CPD) course selection. This study examined patterns of current CPD practice and perceived CPD needs among hospital doctors in Ireland across various clinical specialties. A cross-sectional survey was administered to doctors, focusing on the areas of training needs analysis, CPD course content and preferred course format. In total, 547 doctors identified doctor-patient communication as the skill ranked highest for importance and level of current performance...
July 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28759945/scotopic-contrast-sensitivity-and-glare-after-accelerated-corneal-cross-linking
#20
Soheila Asgari, Hassan Hashemi, Alireza Mohamadi, Ebrahim Jafarzadehpur, Mohammad Miraftab, Saied Shahhoseini, Shiva Mehravaran, Akbar Fotouhi
BACKGROUND: The aim was to assess one-year changes in uncorrected and corrected contrast sensitivity (CS) and glare under scotopic conditions after accelerated cross-linking (CXL) using the 18 mW/cm(2) protocol for the treatment of progressive keratoconus and compare results with unoperated controls. METHODS: In this non-randomised clinical trial, 30 eyes were enrolled in the CXL group and 30 were assigned to the control group. Scotopic CS at spatial frequencies (SFs) of 0...
July 31, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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