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Nancy Howard
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The CPD article explored the importance of sleep and its functions. It also discussed the physical and emotional consequences of inadequate sleep, and how to promote healthy sleep behaviours.
February 15, 2017: Nursing Standard
Xiaoqian Zhang, Xiao-Xi Li, Yufang Liu, Yong Wang
N-benzyl-N-cyclopropylamine (BCA) has been attracting great interests for decades for its partial suicide inactivation role to cytochrome P450 (P450) via a ring-opening mechanism besides acting as a role of normal substrates. Understanding the mechanism of such partial inactivation is vital to the clinical drug design. Thus, density functional theoretical (DFT) calculations were carried out on such P450-catalyzed reactions, not only on the metabolic pathway, but on the ring-opening inactivation one. Our theoretical results demonstrated that, in the metabolic pathway, besides the normal carbinolamine, an unexpected enamine was formed via the dual hydrogen abstraction (DHA) process, in which the competition between rotation of the H-abstracted substrate radical and the rotation of hydroxyl group of the protonated Cpd II moiety plays a significant role in product branch; In the inactivation pathway, the well-noted single electron transfer (SET) mechanism-involved process was invalidated for its high energy barrier, a proton-coupled electron transfer [PCET(ET)] mechanism plays a role...
2017: Frontiers in Chemistry
Ana C N Marques Gomes, Shereen Nabhani-Gebara, Reem Kayyali, Federico Buonocore, Gianpiero Calabrese
OBJECTIVES: To seek community pharmacists' perception on use, safety and possible effectiveness of e-cigarettes as quit smoking tools, and their future regulation. SETTING: A survey of a sample of 154 community pharmacies across London, UK. CONTEXT: E-cigarettes have exclusively established themselves in the market through consumers-led demand. To date, e-cigarettes still remain unregulated and can be easily purchased in shops, over the internet, but more controversially also in pharmacies in the UK...
November 10, 2016: BMJ Open
(no author information available yet)
No abstract text is available yet for this article.
February 11, 2017: Veterinary Record
(no author information available yet)
No abstract text is available yet for this article.
February 11, 2017: Veterinary Record
Joseph Goerres, Ali Uneri, Tharindu De Silva, Michael Ketcha, Sureerat Reaungamornrat, Matthew Jacobson, Sebastian Vogt, Gerhard Kleinszig, Greg Osgood, Jean-Paul Wolinsky, Jeffrey Siewerdsen
Spinal screw placement is a challenging task due to small bone corridors and high risk of neurological or vascular complications, benefiting from precision guidance / navigation and quality assurance (QA). Implicit to both guidance and QA is the definition of a surgical plan - i.e., the desired trajectories and device selection for target vertebrae - conventionally requiring time-consuming manual annotations by a skilled surgeon. We propose automation of such planning by deriving the pedicle trajectory and device selection from a patient's preoperative CT or MR...
February 8, 2017: Physics in Medicine and Biology
(no author information available yet)
There was an error in our CPD article Chronic heart failure part 2: treatment and management (11 January). On page 55, the first sentence in the angiotensin receptor neprilysin inhibitor section should read: Valsartan with sacubitril is an angiotensin receptor neprilysin inhibitor that has recently been approved for use as a replacement for ACE inhibitors, to further reduce the risk of hospitalisation and death in ambulatory patients with heart failure and an ejection fraction ≤35% who remain symptomatic despite optimal treatment with an ACE inhibitor, a beta-blocker and an aldersterone antagonist (Ponikowski et al 2016)...
February 8, 2017: Nursing Standard
Olatunde Ajayi
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The article discussed some of the challenges associated with the self-management of type 1 and type 2 diabetes, and the strategies that can be used to improve patient outcomes.
February 8, 2017: Nursing Standard
Guipan Wang, Congling Zhao, Qiang Ding, Ping Wang
Both visual acuity (VA) and contrast sensitivity (CS) are important parameters for measuring visual function. In this research, we investigated the CS of patients with ametropic or anisometropic amblyopia, whose corrected visual acuity (CVA) recovered to 1.0. Fifty-five cases with amblyopia and 22 control cases with a normal visual acuity of 1.0 were enrolled. The CS of the patients whose ametropic amblyopia had recovered to a CVA of 1.0 at 18 cpd spatial frequency was still lower than that of the normal control group under both photopic and scotopic conditions (P = 0...
February 7, 2017: Scientific Reports
Xin Wang, Susan Hellerstein, Lei Hou, Liying Zou, Yan Ruan, Weiyuan Zhang
BACKGROUND: The caesarean section rate has risen rapidly in China. The purpose of this retrospective study was to estimate caesarean section rates and indications by hospital facility level in Mainland China to investigate reasons contributing to the high rate. METHODS: This cross-sectional hospital-based study collected data from 39 hospitals in three geographical regions in China, covering 14 different provinces, municipalities, and autonomous regions, including 20 tertiary health hospitals and 19 secondary hospitals...
February 6, 2017: BMC Pregnancy and Childbirth
Nathalie Tzourio-Mazoyer, B Mazoyer
In a large sample of 428 healthy adults balanced for gender and manual preference (MP), we investigated planum temporale (PT) surface area variability in relation with Heschl's gyrus (HG) duplication pattern, MP, and familial sinistrality (FS), considering different PT definitions. In a sub-sample of 362 participants, we also investigated whether variability of PT asymmetry was associated with differences in verbal abilities. On each participant brain hemisphere MRI, we delineated a posterior PT area (PTpost), excluding the second Heschl gyrus in case of either complete posterior duplication (CPD) or common stem partial duplication (CSD)...
February 6, 2017: Brain Structure & Function
(no author information available yet)
BVA Congress and CPD courses have been the subject of discussion on the BVA blog.
February 4, 2017: Veterinary Record
Rebecca Keown
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The CPD article discussed the symptoms of catheter-associated urinary tract infections (CAUTIs), the risks involved with catheter use and how to manage catheters safely.
February 1, 2017: Nursing Standard
Paola Torricelli, Milena Fini, Pier Alessandro Fanti, Emi Dika, Massimo Milani
Polypodium leucotomos (PL) exerts potent antioxidant, photo-protective and immune-modulatory activities. A reconstructed human epidermis (RHE) (Episkin) is a suitable model for the evaluation of acute UV-induced cell damage. No data regarding the photo-protective action of PL in this model are available. We evaluated the effects of PL on the prevention of UVB-induced cell damage assessing sunburn cells, CPD formation, p53, Ki-67, p21 expression, and Epidermal Growth Factor (EGF) production. RHE was incubated in standard conditions...
January 31, 2017: Photodermatology, Photoimmunology & Photomedicine
Jingpei Hu, Xiaonan Zhao, Yu Lin, Aijiao Zhu, Xiaojun Zhu, Peiji Guo, Bing Cao, Chinhua Wang
We propose and experimentally demonstrate a high efficient circularly polarizing dichroism waveplate (CPDW) using a Si-based all-dielectric 2Dchiral metasurface. We demonstrate that the CPDW exhibits a unique dichroism in that it functions as a transmissive quarter waveplate for one of either left-or right-handed circularly polarized incident lightand a reflective mirror for the opposite polarization. The circular polarization dichroism (CPD = IRCP - ILCP) in transmission at wavelength ~1.5 μm reaches 97% and the extinction ratio (ER = IRCP/ILCP) is as high as 345:1...
January 31, 2017: Scientific Reports
Alexander Knips, Martin Zacharias
The photo-induced cis-syn-cyclobutane pyrimidine (CPD) dimer is a frequent DNA lesion. In bacteria photolyases efficiently repair dimers employing a light-driven reaction after flipping out the CPD damage to the active site. How the repair enzyme identifies a damaged site and how the damage is flipped out without external energy is still unclear. Employing molecular dynamics free energy calculations, the CPD flipping process was systematically compared to flipping undamaged nucleotides in various DNA global states and bound to photolyase enzyme...
January 27, 2017: Scientific Reports
John Goldie
No abstract text is available yet for this article.
February 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Rachel Makombe
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The CPD article outlined the differences between care plans and care planning. It discussed various nursing theories, tools and models, and how these may be applied to care planning to enhance patient-centred care.
January 25, 2017: Nursing Standard
Bin Sun, Shutao Li, Xiao-Ping Zhang, Jun Sun
Scanned images of historical documents often suffer from bleed-through, which refers to the ink on one side seeping through the paper and appearing on the other side. In this paper, a new conditional random fields (CRF) based method is proposed to remove the bleed-through from the scanned images of historical images. The proposed method only requires the scanned image of one side , referred as a blind method. Generally, the scanned historical document image is composed of three components: foreground, bleed-through and background...
September 27, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Jakob Spiegelberg, Ján Rusz, Kristiaan Pelckmans
A selection of tensor decomposition techniques is presented for the detection of weak signals in electron energy loss spectroscopy (EELS) data. The focus of the analysis lies on the correct representation of the simulated spatial structure. An analysis scheme for EEL spectra combining two-dimensional and n-way decomposition methods is proposed. In particular, the performance of robust principal component analysis (ROBPCA), Tucker Decompositions using orthogonality constraints (Multilinear Singular Value Decomposition (MLSVD)) and Tucker decomposition without imposed constraints, canonical polyadic decomposition (CPD) and block term decompositions (BTD) on synthetic as well as experimental data is examined...
January 11, 2017: Ultramicroscopy
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