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https://www.readbyqxmd.com/read/28639906/preoperative-platelet-to-lymphocyte-ratio-is-a-valuable-prognostic-biomarker-in-patients-with-hepatocellular-carcinoma-undergoing-curative-liver-resection
#1
Hao-Jie Yang, Jing-Hang Jiang, Qing-An Liu, Cheng-Mao Zhou, Yang-Feng Du, Tao Wu, Neng-Zhi Chen, Bang-De Xiang
The Platelet to lymphocyte ratio (PLR) has been reported to predict prognosis of patients with hepatocellular carcinoma (HCC). This study examined the prognostic potential of stratified PLR for HCC patients undergoing curative liver resection. Medical records were retrospectively analyzed for 778 HCC patients undergoing curative liver resection at the Affiliated Tumor Hospital of Guangxi Medical University and the First People's Hospital of Changde between April 2010 and October 2013. Patients were stratified based on quintile analysis of their preoperative PLR, and patients in different quintiles were analyzed for overall survival (OS) and disease-free survival (DFS) using Kaplan-Meier analysis...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28634055/an-insight-on-the-association-of-glycation-with-hepatocellular-carcinoma
#2
REVIEW
Nasimudeen R Jabir, Saheem Ahmad, Shams Tabrez
Hepato-cellular carcinoma (HCC) is one of the frequent cause of cancer-related death worldwide and dominant form of primary liver cancer. However, the reason behind a steady increase in the incidence of this form of cancer remains elusive. Glycation has been reported to play a significant role in the induction of several chronic diseases including cancer. Several risk factors that could induce HCC have been reported in the literature. Deciphering the complex patho-physiology associated with HCC is expected to provide new targets for the early detection, prevention, progression and recurrence...
June 17, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28628564/risk-of-post-transplant-hepatocellular-carcinoma-recurrence-is-higher-in-recipients-of-livers-from-male-than-female-living-donors
#3
Sangbin Han, Ju Dong Yang, Dong Hyun Sinn, Jong Man Kim, Gyu Sung Choi, Gangha Jung, Joong Hyun Ahn, Seonwoo Kim, Justin S Ko, Mi Sook Gwak, Choon Hyuck D Kwon, Michael D Leise, Geum-Youn Gwak, Julie K Heimbach, Gaab Soo Kim
OBJECTIVE: To evaluate the relationship between donor sex and hepatocellular carcinoma (HCC) recurrence after living donor liver transplantation. BACKGROUND: HCC shows a male predominance in incidence and recurrence after tumor resection due to sex differences in hepatic sex hormone receptors. There have been no studies evaluating the importance of donor sex on post-transplant HCC recurrence. METHODS: Of 384 recipients of livers, from living donors, for HCC: 104/120 who received grafts from female donors were matched with 246/264 who received grafts from male donors using propensity score matching, with an unfixed matching ratio based on factors like tumor biology...
June 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28624108/modification-of-immunosuppressive-therapy-as-risk-factor-for-complications-after-liver-transplantation
#4
REVIEW
Paolo De Simone, Paola Carrai, Laura Coletti, Davide Ghinolfi, Stefania Petruccelli, Franco Filipponi
Management of complications post-liver transplantation (LT) includes immunosuppressive manipulations with the aim to reduce the overall burden of immunologic suppression and compensate for renal, cardiovascular, metabolic toxicities, and for the increased oncologic risk. Two approaches can be implemented to reduce immunosuppression-related adverse events: upfront schedules tailored to the pretransplant individual patient's risk profile versus downstream modifications in the event of immunosuppression-related complications...
April 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28615138/wide-versus-narrow-margins-after-partial-hepatectomy-for-hepatocellular-carcinoma-balancing-recurrence-risk-and-liver-function
#5
Wesley B S Field, Jack W Rostas, Prejesh Philps, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
BACKGROUND: The goal of this study was to compare the outcome after partial hepatectomy for hepatocellular carcinoma (HCC) in which a margin less than or equal to 5 mm or greater than 5 mm was achieved. METHODS: A review of our 3300-patient prospective HPB database was performed from 12/2002 to 4/2015. Patients were stratified into two groups: resection margins ≤5 ("narrow") and >5 mm ("wide") as measured on final pathologic assessment. RESULTS: One-hundred thirty patients were included in the analysis (margin ≤5 mm, n = 41 and margin >5 mm, n = 89)...
June 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28603096/patients-with-early-recurrence-of-hepatocellular-carcinoma-have-poor-prognosis
#6
Tomoki Kobayashi, Hiroshi Aikata, Tsuyoshi Kobayashi, Hideki Ohdan, Koji Arihiro, Kazuaki Chayama
BACKGROUND: Early recurrence (ER) after hepatic resection (HR) is a poor prognostic factor for patients with hepatocellular carcinoma (HCC). This study aimed to identify the clinicopathological features, outcomes, and risk factors for ER after HR for small HCC in order to clarify the reasons why ER is a worse recurrence pattern. METHODS: We retrospectively examined 130 patients who underwent HR for small HCC (≤30 mm). Recurrence was classified into ER (<2 years) and late recurrence (LR) (≥2 years)...
June 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28599412/dna-topoisomerase-ii%C3%AE-and-ki67-are-prognostic-factors-in-patients-with-hepatocellular-carcinoma
#7
Yi Cao, Ruisheng Ke, Shaohu Wang, Xu Zhu, Jianwei Chen, Chao Huang, Yi Jiang, Lizhi Lv
The present study was designed to determine the significance of DNA topoisomerase IIa (TopoIIα) and Ki67 in hepatocellular carcinoma cells (HCCs). The present study included 353 patients with HCC. The association of clinicopathological data with the expression of TopoIIα and Ki67 by immunohistochemistry was analyzed by χ(2) test. Cox multivariate proportional hazards regression analysis and Kaplan-Meier analysis were performed with all the variables to derive risk estimates associated with overall survival (OS)/recurrence-free survival (RFS) and to control for confounders...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28591740/prognostic-value-and-preoperative-predictors-of-microvascular-invasion-in-solitary-hepatocellular-carcinoma-%C3%A2-5-cm-without-macrovascular-invasion
#8
Hui Zhao, Ye Hua, Zhihua Lu, Shen Gu, Laifa Zhu, Yuan Ji, Yudong Qiu, Tu Dai, Huihan Jin
OBJECTIVES: The aim of this study was to investigate the prognostic value and preoperative predictors of microvascular invasion (MVI) in solitary hepatocellular carcinoma (HCC) ≤ 5 cm without macrovascular invasion. METHODS: A total of 233 consecutive HCC patients underwent curative hepatectomy were included in our study. Independent risk factors influencing the prognosis were identified, and preoperative predictors for MVI were determined. RESULTS: Multivariate regression analysis identified ICG-R15, BCLC staging and MVI as independent risk factors for the overall survival rate...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28589639/significance-of-presence-of-microvascular-invasion-in-specimens-obtained-after-surgical-treatment-of-hepatocellular-carcinoma
#9
REVIEW
Xiaofeng Zhang, Jun Li, Feng Shen, Wan Yee Lau
Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long-term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens...
June 6, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28583823/regulator-of-calcineurin-1-gene-isoform-4-downregulated-in-hepatocellular-carcinoma-prevents-proliferation-migration-and-invasive-activity-of-cancer-cells-and-growth-of-orthotopic-tumors-by-inhibiting-nuclear-translocation-of-nfat1
#10
Haojie Jin, Cun Wang, Guangzhi Jin, Haoyu Ruan, Dishui Gu, Lin Wei, Hui Wang, Ning Wang, Einthavy Arunachalam, Yurong Zhang, Xuan Deng, Chen Yang, Yi Xiong, Hugang Feng, Ming Yao, Jingyuan Fang, Jianren Gu, Wenming Cong, Wenxin Qin
BACKGROUND & AIMS: Individuals with Down syndrome have a low risk for many solid tumors, prompting the search for tumor suppressor genes on human chromosome 21 (HSA21). We aimed to identify and explore potential mechanisms of suppressors on HSA21 in hepatocellular carcinoma (HCC). METHODS: We compared expression of HSA21 genes in 14 pairs of primary HCC and adjacent noncancer liver tissue using the Affymetrix HG-U133 Plus 2.0 array. HCC tissues and adjacent normal liver tissues were collected from 108 patients at a hospital in China for real-time PCR and immunohistochemical analyses; expression levels of regulator of calcineurin 1 (RCAN1) isoform 4 (RCAN1...
June 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28583536/primary-living-donor-liver-transplantation-is-not-the-optimal-treatment-choice-in-patients-with-early-hepatocellular-carcinoma-with-poor-tumor-biology
#11
M-S Park, K-W Lee, H Kim, Y R Choi, G Hong, N-J Yi, K-S Suh
OBJECTIVE: Liver resection (LR) and living-donor liver transplantation (LDLT) are considered the two potentially curative treatments for hepatocellular carcinoma (HCC). The aim of this study was to investigate whether there is a difference in the oncologic outcomes between LR and LDLT according to tumor biology. METHODS: Patients (137 LDLTs and 199 LRs) were stratified into four groups by tumor biology according to the number of risk factors for recurrence (preoperative alpha-fetoprotein >200 ng/mL, Edmonson grade 3 or 4, tumor size >3 cm, and presence of microvascular invasion)...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28559922/association-of-hepatitis-status-with-surgical-outcomes-in-patients-with-dual-hepatitis-b-and-c-related-hepatocellular-carcinoma
#12
Xiu-Tao Fu, Ying-Hong Shi, Jian Zhou, Yuan-Fei Peng, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Kang Song, Jia Fan, Zhen-Bin Ding
BACKGROUND: The conception that serological hepatitis markers determined surgical prognosis of hepatocellular carcinoma (HCC) associated with hepatitis B (HBV) or hepatitis C (HCV) has been well defined. However, little is known about the relationship between surgical outcomes and serological hepatitis markers in patients with dual HBV and HCV related HCC. METHODS: A retrospective analysis of the clinical data of 39 HCC patients with HBV-HCV coinfection who underwent curative hepatectomy between 2001 and 2011 was performed...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28555436/relationship-of-hepatitis-b-virus-infection-to-the-recurrence-of-hepatocellular-carcinoma-after-direct-acting-antivirals
#13
Hirohito Shimizu, Keiji Matsui, Shogo Iwabuchi, Tomoaki Fujikawa, Mitsuru Nagata, Kentaro Takatsuka, Hiroyuki Tanemura, Haruhiro Nakazaki, Masayuki Nakano, Tsunamasa Watanabe
Recently, two conflicting articles about recurrence of hepatocellular carcinoma (HCC) after direct acting antivirals (DAA) against hepatitis C virus (HCV) were published. We investigated the relationship between DAA and HCC recurrence. Eligible patients were (1) history of HCC and treated curatively with interventions, and (2) interferon-free DAA therapy was initiated after eradication of HCC. We analyzed contributing factor for HCC recurrence. Ten out of 23 participants (43%) encountered recurrence of HCC...
May 30, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28554743/edmondson-steiner-grade-a-crucial-predictor-of-recurrence-and-survival-in-hepatocellular-carcinoma-without-microvascular-invasio
#14
Li Zhou, Jing-An Rui, Wei-Xun Zhou, Shao-Bin Wang, Shu-Guang Chen, Qiang Qu
BACKGROUND: Microvascular invasion (MVI), an important pathologic parameter, has been proven to be a powerful predictor of long-term prognosis in hepatocellular carcinoma (HCC). However, prognostic factors in HCC without MVI remain unknown. The present study aimed to identify the risk factors of recurrence and poor post-resectional survival in this type of HCC. METHODS AND METHODS: A total of 109 patients with MVI-absent HCC underwent radical hepatectomy were enrolled...
March 8, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28540985/predictors-of-micrometastases-in-patients-with-barcelona-clinic-liver-cancer-classification-b-hepatocellular-carcinoma
#15
Suk Won Suh, Yoo Shin Choi
PURPOSE: Transarterial chemoembolization (TACE) is indicated for Barcelona Clinic Liver Cancer (BCLC) B hepatocellular carcinoma (HCC). Whether TACE provides any long-term survival benefits remains unclear. We aimed to investigate micrometastases predictors with which to identify patients who would benefit from surgical resection (SR). MATERIALS AND METHODS: First, we analyzed risk factors of micrometastases, microvascular invasion, and poor histologic grade in 38 patients with newly diagnosed resectable BCLC stage B HCC limited to one or two segments with well-preserved liver function and who underwent SR between January 2006 and December 2013...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28501131/microrna-203-promotes-liver-regeneration-after-partial-hepatectomy-in-cirrhotic-rats
#16
Xiao-Bo Chen, Xiao-Bo Zheng, Zhen-Xing Cai, Xian-Jian Lin, Ming-Qing Xu
BACKGROUND: Liver resection or partial hepatectomy (PH) is still the most commonly used therapeutic option for hepatocellular carcinoma (HCC) at present. However, the impaired regenerative ability induced by the accompanied liver cirrhosis is an important risk factor of posthepatectomy liver failure, and posthepatectomy liver failure is a feared complication that accounts for up to 75% of mortality after extensive liver resection. MicroRNA(miR)-203 is a tumor suppressor of HCC and may act as a positive intermediary in A20-enhanced interleukin (IL-6)/signal transducer and activator of transcription 3 (STAT3) pro-proliferative signals, which may promote liver regeneration after PH...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28480517/the-clinical-outcomes-of-patients-with-portal-vein-tumor-thrombi-after-living-donor-liver-transplantation
#17
Ho Joong Choi, Dong Goo Kim, Gun Hyung Na, Tae Ho Hong, Si Hyun Bae, Young Kyoung You, Jong Young Choi, Seung Kew Yoon
INTRODUCTION: The purpose of this study was to evaluate the feasibility of living-donor liver transplantation (LDLT) for treatment of patients with hepatocellular carcinoma (HCC) and segmental portal vein tumor thrombi (PVTT) below the second-order branch. PATIENTS AND METHODS: Between January 2005 and December 2015, we retrospectively analyzed 242 patients in a control group (n = 184), a microvascular invasion (MVI) group (n = 24), and a PVTT group (n = 34). To assess the risks associated with PVTT, we evaluated recurrence, the disease-free survival rate (DFS), the overall survival rate (OS), and various other factors based on the characteristics of patients and tumors...
May 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28464845/hepatitis-b-virus-infection-and-active-replication-promote-the-formation-of-vascular-invasion-in-hepatocellular-carcinoma
#18
Xubiao Wei, Nan Li, Shanshan Li, Jie Shi, Weixing Guo, Yaxin Zheng, Shuqun Cheng
BACKGROUND: Vascular invasion, including microvascular invasion (MVI) and portal vein tumor thrombus (PVTT), is associated with the postoperative recurrence of hepatocellular carcinoma (HCC). We aimed to investigate the potential impact of hepatitis B virus (HBV) activity on the development of vascular invasion. METHODS: Patients with HBV and tumor-related factors of HCC who had undergone hepatectomy were retrospectively enrolled and analyzed to identify the risk factors for developing vascular invasion...
May 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28457412/factors-related-to-hepatocellular-carcinoma-recurrence-after-liver-transplantation-a-brazilian-multicenter-study
#19
M Bina Possatto, E C de Ataíde, C A Fazzio Escanhoela, T Sevá-Pereira, R de Cassia Martins Alves da Silva, H Felicio, L R de Navarro Amado, R Ferreira da Silva, A Soares Lima, I F S F Boin
BACKGROUND: Liver transplantation (LT) is a curative treatment option for hepatocellular carcinoma (HCC); recurrent HCC after liver transplantation (HCC-R) is diagnosed in 9%-16%. The objective of this study was to evaluate which factors are associated with R-HCC after liver transplantation. METHODS: This retrospective real-life study analyzed 278 LTs from 3 reference centers (2,093 LTs) in Brazil from 1988 to 2015. HCC-R with histologic confirmation was seen in 40 patients (14...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28457411/immunoexpression-of-heat-shock-protein-70-glypican-3-glutamine-synthetase-and-beta-catenin-in-hepatocellular-carcinoma-after-liver-transplantation-association-between-positive-glypican-3-and-beta-catenin-with-the-presence-of-larger-nodules
#20
E C Ataide, S R Perales, M G Silva, F C Filho, A C Sparapani, P F Latuf Filho, R S B Stucchi, J Vassallo, C A F Escanhoela, I F S F Boin
BACKGROUND: Hepatocellular carcinoma (HCC) is the 6th leading cause of cancer worldwide. Its recurrence ranges from 6% to 26%. In the literature, many factors are associated with higher risk of recurrence, without a clear definition of the best method that could predict this highly lethal event. OBJECTIVE: The aim of this study was to evaluate the immunoexpression of immunohistochemical markers: HSP70, glypican 3, glutamine synthetase, and beta-catenin, as well as studying their association with tumor characteristics and prognosis of patients undergoing liver transplantation for HCC...
May 2017: Transplantation Proceedings
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