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recurrent risk factors hepatocellular carcinoma

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https://www.readbyqxmd.com/read/28936708/impact-of-visceral-adiposity-as-well-as-sarcopenic-factors-on-outcomes-in-patients-undergoing-liver-resection-for-colorectal-liver-metastases
#1
Atsushi Kobayashi, Toshimi Kaido, Yuhei Hamaguchi, Shinya Okumura, Hisaya Shirai, Naoko Kamo, Shintaro Yagi, Kojiro Taura, Hideaki Okajima, Shinji Uemoto
OBJECTIVES: We have reported preoperative low skeletal muscularity as an independent risk factor for poor outcomes after liver transplantation, resection of hepatocellular carcinoma, pancreatic cancer and extrahepatic biliary malignancies. However, the impacts of visceral adiposity and muscularity on outcomes after liver resection for colorectal liver metastases (CLM) have not been fully investigated. METHODS: We retrospectively analyzed 124 patients undergoing primary liver resection for CLM between 2005 and 2014...
September 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28927498/drug-treatment-for-chronic-hepatitis-c-infection-and-cancer-risk
#2
Marcus-Alexander Wörns, Peter Robert Galle, Stefan Zeuzem, Peter Schirmacher, Michael Manns, Arndt Vogel
BACKGROUND: In patients with chronic hepatitis C infection, a sustained virologic response (SVR) to interferon-based therapy markedly decreases the incidence of hepatocellular carcinoma (HCC) over the long term. This is also true for patients who have hepatic cirrhosis, as well as for those with HCC-with or without cirrhosis-who have undergone resection or ablation with curative intent. Recent publications, however, have reported a higher incidence of HCC among patients in both of these subgroups who were treated with direct antiviral agents (DAA) rather than interferon-based therapy...
September 4, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28923632/liver-transplantation-in-patients-with-complete-portal-vein-thrombosis-renoportal-or-varicoportal-anastomosis-using-cryopreserved-vein-grafts
#3
H Aktas, A Ozer, O S Guner, E Gurluler, R Emiroglu
BACKGROUND: Despite technical developments in transplantation surgery, complete portal vein thrombosis still remains a challenge for restoration of adequate portal vein inflow. Renoportal or varicoportal anastomosis provides an effective alternative solution for patients with complete portal vein thrombosis. This study describes our experience with renoportal and varicoportal anastomosis during liver transplantation. PATIENTS AND METHODS: Between January 2014 and May 2016, 5 patients with complete portal vein thrombosis underwent extra-anatomic portal anastomosis...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28918833/recurrence-of-barcelona-clinic-liver-cancer-stage-a-hepatocellular-carcinoma-after-hepatectomy
#4
Hao Zou, Cheng-Zhan Zhu, Chang Wang, Zu-Sen Wang, Xiang Ma, Bing Han, Li-Qun Wu
BACKGROUND: The Barcelona Clinic Liver Cancer (BCLC) staging system is widely used to classify hepatocellular carcinoma (HCC). This study was performed to investigate the prognostic factors for patients with BCLC stage A HCC after R0 hepatectomy. METHODS: A total of 592 patients with BCLC stage A HCC following R0 hepatectomy from 1997-2012 were enrolled in this study. Kaplan-Meier analysis and Cox regression were used to analyze the risk factors associated with recurrence...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28916899/impact-of-surgical-complications-on-the-risk-of-hepatocellular-carcinoma-recurrence-after-hepatic-resection
#5
Riccardo Pravisani, Umberto Baccarani, Miriam Isola, Gianluigi Adani, Dario Lorenzin, Giovanni Terrosu, Andrea Risaliti
Surgery-related morbidity has been identified as prognostic risk factor for tumor recurrence for several tumor types, but data regarding hepatocellular carcinoma (HCC) are limited and controversial. The aim of this study was to analyze the impact of surgical complications on the risk of HCC recurrence after hepatic resection (HR). A Retrospective study was conducted on a cohort of patients submitted to HR in a tertiary teaching hospital, between January 2006 and December 2015. 112 patients were submitted to HR during the study period...
September 15, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28881553/-association-between-a-kinase-anchor-proteins-12-methylation-and-recurrence-of-hepatocellular-carcinoma
#6
Z J Liu, W Liu, C H Cui, L K Gu, B C Xing, D J Deng
Objective: To study the association between the AKAP12 promoter methylation and recurrence of hepatocellular carcinoma. Methods: A total of 142 primary liver cancer patients underwent surgery in department of Hepatobiliary surgery in Peking University Cancer Hospital from 2003 to 2009 were selected as subjects in the survey; with the inclusion criteria as hepatocellular carcinoma, no cancer cells were observed in the surgical margin(SM) samples. All patients had neither lymph nor distant metastasis at the time of surgery, and receiving complete follow-up data for at least 3 years...
September 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28875240/potential-predictive-factors-for-microvascular-invasion-in-hepatocellular-carcinoma-classified-within-the-milan-criteria
#7
Satoru Imura, Hiroki Teraoku, Masato Yoshikawa, Daichi Ishikawa, Shinichiro Yamada, Yu Saito, Shuichi Iwahashi, Tetsuya Ikemoto, Yuji Morine, Mitsuo Shimada
BACKGROUND: Microvascular invasion (mvi) is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. However, mvi is difficult to detect preoperatively. The aim of this study was to clarify the risk factors of postoperative recurrence and investigate predictive factors of mvi before hepatectomy for HCC classified within the Milan criteria. METHODS: One hundred fifty-nine patients with hepatocellular carcinoma (HCC) classified within the Milan criteria, who underwent hepatectomy, were enrolled in this study...
September 5, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28869445/clinical-significance-of-serum-14-3-3-beta-in-patients-with-hepatocellular-carcinoma
#8
Hai Lin, Xuelong Jiao, Benxia Yu, Jiangdong Du, HaiYan Xu, Aiping Dong, Chunsheng Wan
OBJECTIVE: The 14-3-3 family of conserved regulatory proteins comprises the isoforms beta (β), gamma (γ), zeta (ζ), sigma (ε), tau (η), and delta (σ), which are overexpressed and associated with a high risk of metastasis and poor survival in hepatocellular carcinoma (HCC). In the present study, we investigated whether serum 14-3-3 isoforms are related to HCC progression and patient survival. METHODS: Serum samples from 63 HCC patients who underwent surgical reSection 104 HCC patients who received non-surgical anti-HCC treatments, 50 patients with liver cirrhosis alone, 45 patients with chronic hepatitis alone, and 50 healthy subjects were collected between January 2006 and December 2010...
August 23, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28863781/downregulation-of-gpr155-as-a-prognostic-factor-after-curative-resection-of-hepatocellular-carcinoma
#9
Shinichi Umeda, Mitsuro Kanda, Hiroyuki Sugimoto, Haruyoshi Tanaka, Masamichi Hayashi, Suguru Yamada, Tsutomu Fujii, Hideki Takami, Yukiko Niwa, Naoki Iwata, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: Molecular biomarkers capable of predicting recurrence patterns and prognosis are helpful for risk stratification and providing appropriate treatment to patients with hepatocellular carcinoma (HCC). In this study, we focused on G protein-coupled receptor 155 (GPR155), a cell surface signaling protein, as a candidate biomarker. METHODS: We analyzed GPR155 expression, DNA methylation, and copy number in HCC cell lines. The clinical significance of GPR155 expression was evaluated using 144 pairs of surgically resected liver and normal tissues with subgroup analysis based on hepatitis virus infection...
September 1, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28857208/temporal-trends-clinical-patterns-and-outcomes-of-nafld-related-hcc-in-patients-undergoing-liver-resection-over-a-20-year-period
#10
R Pais, L Fartoux, C Goumard, O Scatton, D Wendum, O Rosmorduc, V Ratziu
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of hepatocellular carcinoma (HCC) worldwide. NAFLD-HCC often occurs in noncirrhotic liver raising important surveillance issues. AIM: To determine the temporal trends for prevalence, clinical characteristics and outcomes of NAFLD-HCC in patients undergoing liver resection. METHODS: Consecutive patients with histologically confirmed HCC who underwent liver resection over a 20-year period (1995-2014)...
August 31, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28855589/sorcin-predicts-poor-prognosis-and-promotes-metastasis-by-facilitating-epithelial-mesenchymal-transition-in-hepatocellular-carcinoma
#11
Xiong Lei, Yahang Liang, Jian Chen, Shuai Xiao, Jian Lei, Jianfeng Li, Jinzhong Duanmu, Qunguang Jiang, Dongning Liu, Cheng Tang, Taiyuan Li
Metastasis-associated recurrence is the main cause for the poor prognosis of hepatocellular carcinoma (HCC). However, the detailed molecular mechanisms underlying HCC metastasis remain elusive. Though some data indicated the oncogenic role of Sorcin in tumors, the prognostic value and biological role of Sorcin in HCC is still unknown. In this study, it demonstrated that Sorcin expression levels were significantly upregulated in HCC tumor tissues compared with matched adjacent nontumorous liver tissues and normal liver tissues, and such expression level correlated with HCC metastasis...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837444/small-hepatocellular-carcinoma-with-low-tumor-marker-expression-benefits-more-from-anatomical-resection-than-tumors-with-aggressive-biology
#12
Dong-Hwan Jung, Shin Hwang, Young-Joo Lee, Ki-Hun Kim, Gi-Won Song, Chul-Soo Ahn, Deok-Bog Moon, Sung-Gyu Lee
OBJECTIVE: We assessed prognostic advantage of anatomical resection (AR) over nonanatomical resection (NAR) for hepatocellular carcinoma (HCC) according to multiplication of α-fetoprotein, des-γ-carboxyprothrombin, and tumor volume (ADV) scores. BACKGROUND: Superiority of AR over NAR is debated. ADV score is surrogate marker of postresection prognosis for solitary HCC. METHODS: This study included 1572 patients who underwent curative resection for solitary HCC of 2...
August 23, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28830473/survival-outcomes-of-hepatectomy-for-stage-b-hepatocellular-carcinoma-in-the-bclc-classification
#13
Toshiya Kamiyama, Tatsuya Orimo, Kenji Wakayama, Shingo Shimada, Akihisa Nagatsu, Hideki Yokoo, Hirofumi Kamachi, Kenichiro Yamashita, Tsuyoshi Shimamura, Akinobu Taketomi
BACKGROUND: Because hepatectomy is not recommended in patients with stage B hepatocellular carcinoma (HCC) of the Barcelona Clinic Liver Cancer (BCLC) staging, we evaluated the survival outcomes of hepatectomy for stage B in the BCLC system. METHODS: Data were collected from 297 consecutive adult stage B patients who underwent curative hepatectomy for HCC between 1996 and 2014 in Hokkaido University Hospital. Overall survival (OS), disease-free survival (DFS), and risk factors were analyzed using the Kaplan-Meier method...
August 22, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28827903/predictors-of-outcome-of-living-donor-liver-transplantation-for-hepatocellular-carcinoma
#14
Hazem Mohamed Zakaria, Ahmed N Sallam, Islam I Ayoub, Sherif M Saleh, Doha Maher, Hazem Omar, Mohamed Abou-Shady, Ibrahim A Salama, El-Sayed A Soliman, Khaled Abou El-Ella, Tarek M Ibrahim, Essam M Hammad
The aim of this work is to study the different factors that affect the outcome of living donor liver transplantation for patients with hepatocellular carcinoma (HCC). Between April 2003 to November 2014, 62 patients with liver cirrhosis and HCC underwent living donor liver transplantation (LDLT) in the National Liver Institute, Menoufia University, Egypt. The preoperative, operative, and postoperative data were analyzed. After studying the pathology of explanted liver; 44 (71 %) patients were within the Milan criteria, and 18 (29 %) patients were beyond Milan; 13 (21...
August 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28821282/down-regulation-of-the-tumour-suppressor-%C3%AE%C2%BA-opioid-receptor-predicts-poor-prognosis-in-hepatocellular-carcinoma-patients
#15
Dongtai Chen, Yonghua Chen, Yan Yan, Jiahao Pan, Wei Xing, Qiang Li, Weian Zeng
BACKGROUND: Opioid receptors have become increasingly implicated in cancer progression and long-term patient outcomes. However, the expression and significance of the κ-opioid receptor (KOR) in hepatocellular carcinoma (HCC) remain unclear. METHODS: In this study, KOR mRNA expression was analysed by real-time quantitative PCR in 64 pairs of HCC tumour tissues and adjacent non-tumour tissues, and KOR protein expression was analysed by immunohistochemistry in 174 HCC patients...
August 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28819409/a-retrospective-discussion-of-the-prognostic-value-of-combining-prothrombin-time-pt-and-fibrinogen-fbg-in-patients-with-hepatocellular-carcinoma
#16
Xue-Ping Wang, Min-Jie Mao, Zhong-Lian He, Lin Zhang, Pei-Dong Chi, Jia-Rui Su, Shu-Qin Dai, Wan-Li Liu
Aims: The levels of coagulation system tests have been studied in various cancers. In this study, our aim is to evaluate the prognostic value of pretreatment plasma coagulation tests in hepatocellular carcinoma (HCC) patients. Patient and methods: A retrospective study was performed in 539 patients with HCC, and follow-up period was at least 60 months until recurrence or death. The prognostic significance of coagulation system tests (prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen) were determined by univariate and multivariate Cox hazard models...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28816953/peritumoral-decreased-uptake-area-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging-and-tumor-recurrence-after-surgical-resection-in-hepatocellular-carcinoma-a-strobe-compliant-article
#17
Seung Kak Shin, Yun Soo Kim, Young Sup Shim, Seung Joon Choi, So Hyun Park, Dong Hae Jung, Oh Sang Kwon, Duck Joo Choi, Ju Hyun Kim
Recently, it has been suggested that peritumoral decreased uptake area (PDUA) in the hepatobiliary phase (HBP) of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) was associated with vascular invasion in hepatocellular carcinoma (HCC). We aimed to investigate correlations between microvascular invasion and PDUA, and elucidate the predictability of PDUA for tumor recurrence after resection.We retrospectively analyzed clinicopathological and radiological data from 126 consecutive patients with single HCC ≤5 cm without macrovascular invasion who underwent preoperative Gd-EOB-DTPA-enhanced MRI and surgical resection...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816936/adjuvant-transarterial-chemoembolization-after-radical-resection-contributed-to-the-outcomes-of-hepatocellular-carcinoma-patients-with-high-risk-factors
#18
Zhendong Gao, Gang Du, Yuguang Pang, Zhihao Fu, Chongzhong Liu, Yi Liu, Binghai Zhou, Du Kong, Binyao Shi, Zhengcheng Jiang, Bin Jin
We aim to investigate the effects of postoperative adjuvant transarterial chemoembolization (TACE) on survival and recurrence in hepatocellular carcinoma (HCC) patients after radical resection. A total of 320 HCC patients underwent radical resection between January 2010 and January 2014 in Qilu Hospital, Shandong University were divided into 4 groups according to the frequency of postoperative adjuvant TACE. Patients were further stratified into subgroups (tumor diameter ≤5 or >5 cm) with low or high risk factors for recurrence or death...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28815223/hepatocellular-carcinoma-when-is-liver-transplantation-oncologically-futile
#19
REVIEW
André Viveiros, Heinz Zoller, Armin Finkenstedt
Selection criteria of patients with hepatocellular carcinoma (HCC) for liver transplantation (LT) have been progressively expanded since the introduction of the Milan criteria. Transplanting patients with unfavourable tumor characteristics increases the risk of tumor recurrence and impacts post-transplant survival. Although tumor number and size are the basis of widely accepted selection criteria and correlate with tumor grading and microvascular invasion, stronger predictors of tumor recurrence have been recently identified...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28810252/the-impact-of-the-hepatitis-b-core-antibody-status-on-recurrence-in-patients-with-non-b-non-c-hepatocellular-carcinoma-after-curative-surgery
#20
Yukiyasu Okamura, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhiko Uesaka
BACKGROUND: The serum antibody to hepatitis B core antigen (HBcAb) is considered a risk factor of liver carcinogenesis. This study aimed to reveal whether HBcAb status is a prognostic factor after hepatectomy is performed for treating hepatocellular carcinoma (HCC). METHODS: This retrospective study enrolled 272 patients who underwent hepatectomy as the initial treatment for HCC and who were followed up over 5 years after surgery. The types of HCC were classified into the following 3 types according to the hepatitis virus infection status and the patients without hepatitis virus infection non-B non-C HCC (NBNC-HCC) were further classified into 2 groups...
August 16, 2017: Digestive Surgery
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