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recurrent risk factors hepatocellular carcinoma

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https://www.readbyqxmd.com/read/28334430/radiofrequency-ablation-using-a-10-mm-target-margin-for-small-hepatocellular-carcinoma-in-patients-with-liver-cirrhosis-a-prospective-randomized-trial
#1
Mingheng Liao, Xiaofei Zhong, Jingyi Zhang, Yangyang Liu, Zexin Zhu, Hong Wu, Yong Zeng, Jiwei Huang
BACKGROUND AND OBJECTIVES: To compare 3-year clinical outcomes of radiofrequency ablation (RFA) targeting 5- or 10-mm margins for small hepatocellular carcinomas (HCCs) in cirrhotic patients. METHODS: In total, 96 cirrhotic patients with a small solitary HCC (diameter ≤3 cm) were included in this prospective trial (ChiCTRTRC-10000954). Patients were stratified by Child-Pugh class and randomly allocated into groups targeting either wide margins (≥10 mm, WM) or narrow margins (≥5 mm but <10 mm, NM)...
March 23, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28332314/the-mitochondrial-hinge-protein-uqcrh-is-a-novel-prognostic-factor-for-hepatocellular-carcinoma
#2
Eun-Ran Park, Sang-Bum Kim, Jee-San Lee, Yang-Hyun Kim, Dong-Hyoung Lee, Eung-Ho Cho, Sun-Hoo Park, Chul Ju Han, Bu-Yeo Kim, Dong Wook Choi, Young Do Yoo, Ami Yu, Jae Won Lee, Ja June Jang, Young Nyun Park, Kyung-Suk Suh, Kee-Ho Lee
Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol-cytochrome c reductase hinge protein (UQCRH) consists of the cytochrome bc1 complex serving respiration in mitochondria. In the present study, we analyzed UQCRH abnormalities in hepatocellular carcinoma (HCC) and its association with clinical outcomes of patients. UQCRH expression in HCC was determined via semiquantitative and quantitative real-time reverse transcriptase polymerase chain reaction of 96 surgically resected HCC tissues positive for hepatitis B virus surface antigen...
March 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28326886/recurrence-of-hepatocellular-carcinoma-after-laparoscopic-hepatectomy-risk-factors-and-treatment-strategies
#3
Xiaodong Xu, Jiahui Chen, Feiran Wang, Qinggan Ni, Ullah Naimat, Zhong Chen
PURPOSE: To investigate the risk factors for recurrence and treatment strategies after patients with hepatocellular carcinoma (HCC) undergo total laparoscopic hepatectomy (LH). METHODS: The study included 109 patients who underwent LH (laparoscopy resection [LR] group, n = 50) or open hepatectomy [OH] (open resection [OR] group, n = 59) for HCC in our hospital between March 2011 and June 2016. Perioperative outcomes, disease recurrence, survival, and risk factors for recurrence were analyzed...
March 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28326662/prediction-of-recurrence-following-hepatectomy-in-patients-with-hepatitis-c-virus-infection-related-hepatocellular-carcinoma-who-achieved-a-sustained-virological-response
#4
Sho Okimoto, Tsuyoshi Kobayashi, Shintaro Kuroda, Kohei Ishiyama, Kentaro Ide, Masahiro Ohira, Hiroyuki Tahara, Seiichi Shimizu, Hiroshi Iwako, Michinori Hamaoka, Naruhiko Honmyo, Megumi Yamaguchi, Hideki Ohdan
AIM: The risk of hepatitis C virus infection-related hepatocellular carcinoma (HCC) is lower, with a better prognosis, in patients who achieve a sustained virological response (SVR) than in those who do not. We aimed to identify risk factors of post-hepatectomy HCC recurrence in patients who achieved a SVR. METHODS: This retrospective study included 349 HCC patients who underwent an initial radical hepatectomy at our institution between January 2005 and December 2014...
March 21, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28296727/prognostic-nomogram-for-patients-with-hepatocellular-carcinoma-underwent-adjuvant-transarterial-chemoembolization-following-curative-resection
#5
Chu-Yu Jing, Yi-Peng Fu, Su-Su Zheng, Yong Yi, Hu-Jia Shen, Jin-Long Huang, Xin Xu, Jia-Jia Lin, Jian Zhou, Jia Fan, Zheng-Gang Ren, Shuang-Jian Qiu, Bo-Heng Zhang
Adjuvant transarterial chemoembolization (TACE) is a major option for postoperative hepatocellular carcinoma (HCC) patients with recurrence risk factors. However, individualized predictive models for subgroup of these patients are limited. This study aimed to develop a prognostic nomogram for patients with HCC underwent adjuvant TACE following curative resection.A cohort comprising 144 HCC patients who received adjuvant TACE following curative resection in the Zhongshan Hospital were analyzed. The nomogram was formulated based on independent prognostic indicators for overall survival (OS)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28294176/salvage-liver-transplantation-leads-to-poorer-outcome-in-hepatocellular-carcinoma-compared-with-primary-liver-transplantation
#6
Yuhua Shan, Lifeng Huang, Qiang Xia
Hepatocellular carcinoma is the most common liver malignancy. Salvage liver transplantation (SLT) is viewed as a feasible cure for recurrence of HCC after resectomy, but the effect is under dispute. A retrospective study examined data at Renji Hospital for 239 transplants from January 2006 to December 2015, including 211 who received primary liver transplantation (PLT) and 28 who underwent SLT. A multivariable cox regression model was employed to pick out relative factors to overall survival (OS) and recurrence free survival (RFS)...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28288626/hepatitis-c-related-hepatocellular-carcinoma-in-the-era-of-new-generation-antivirals
#7
REVIEW
Thomas F Baumert, Frank Jühling, Atsushi Ono, Yujin Hoshida
Hepatitis C virus infection is a major cause of hepatocellular carcinoma worldwide. Interferon has been the major antiviral treatment, yielding viral clearance in approximately half of patients. New direct-acting antivirals substantially improved the cure rate to above 90%. However, access to therapies remains limited due to the high costs and under-diagnosis of infection in specific subpopulations, e.g., baby boomers, inmates, and injection drug users, and therefore, hepatocellular carcinoma incidence is predicted to increase in the next decades even in high-resource countries...
March 14, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28276470/simple-risk-score-for-prediction-of-early-recurrence-of-hepatocellular-carcinoma-within-the-milan-criteria-after-orthotopic-liver-transplantation
#8
Jiliang Feng, Jushan Wu, Ruidong Zhu, Dezhao Feng, Lu Yu, Yan Zhang, Dayu Bu, Chenlei Li, Yuyan Zhou, Lianghao Si, Yuhan Liu, Ziwei Liang, Jianing Xu, Tianjun Wu
Ten to twenty percent of the hepatocellular carcinoma (HCC) patients fulfilling the Milan criteria (MC) recurred within three years after orthotopic liver transplantation (OLT). We therefore utilize a training cohort to develop an improved prognostic model for predicting the recurrence in these patients. By univariate and multivariate analysis, AFP level [cut-off value: 321 ng/mL, area under the curve (AUC) = 0.724, 95% confidence interval (CI) = 0.604-0.843, P < 0.001] and cytokeratin-19 (CK19) and glypican-3 (GPC3) expression pattern from nine putative prognostic factors were entered in risk factor scoring model to conjecture the tumor recurrence...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28258663/diabetes-mellitus-not-as-an-unfavorable-factor-on-the-prognosis-of-hepatitis-c-virus-related-hepatocellular-carcinoma
#9
Naoki Yoshida, Yutaka Midorikawa, Tokio Higaki, Hisashi Nakayama, Shingo Tsuji, Shunichi Matsuoka, Hisamitsu Ishihara, Mitsuhiko Moriyama, Tadatoshi Takayama
AIM: Diabetes mellitus (DM) is a potential risk factor for hepatocarcinogenesis, especially in patients with hepatitis C virus (HCV) infection. We aimed to elucidate whether DM influences the surgical outcomes of patients with hepatocellular carcinoma (HCC). METHODS: Our patients were routinely controlled to keep urinary glucose excretion to less than 3.0 g/day before surgery, and the serum glucose level under 200 mg/dl after surgery. The surgical outcomes and postoperative complications of 112 patients with HCV-related HCC with DM (DM Group) were compared to those of 112 propensity-matched patients without DM (non-DM Group)...
March 4, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28205284/prognostic-impact-of-complications-after-resection-of-early-stage-hepatocellular-carcinoma
#10
Georgios Antonios Margonis, Kazunari Sasaki, Nikolaos Andreatos, Yujiro Nishioka, Toshitaka Sugawara, Neda Amini, Stefan Buettner, Masaji Hashimoto, Junichi Shindoh, Timothy M Pawlik
BACKGROUND: Resection is the most effective treatment for HCC. However, postoperative morbidity is common and its impact on long-term oncological outcome remains unclear. METHODS: Long-term outcomes of 774 patients who underwent curative resection for early stage HCC at Johns Hopkins Hospital and Toranomon Hospital were investigated after stratifying by the development of postoperative overall and infectious complications. RESULTS: A minor or major postoperative complication developed in 281 and 65 patients, respectively, while postoperative mortality was 1...
February 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28197709/glasgow-prognostic-score-and-prognosis-after-hepatectomy-for-hepatocellular-carcinoma
#11
Tomoyuki Abe, Hirotaka Tashiro, Tsuyoshi Kobayashi, Minoru Hattori, Shintaro Kuroda, Hideki Ohdan
BACKGROUND: Systemic inflammation can promote tumor growth. The Glasgow Prognostic Score (GPS), a simple assessment of systemic inflammation status, could be useful to predict the prognosis of hepatocellular carcinoma (HCC) patients after hepatectomy. METHODS: Consecutive HCC patients were enrolled following hepatectomy at our institution between 2005 and 2012. Univariate and multivariate analyses were performed to identify variables associated with overall survival (OS) and recurrence-free survival...
February 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28192617/huge-hepatocellular-carcinoma-greater-than-10%C3%A2-cm-in-diameter-worsens-prognosis-by-causing-distant-recurrence-after-curative-resection
#12
Kenji Wakayama, Toshiya Kamiyama, Hideki Yokoo, Tatsuya Orimo, Shingo Shimada, Takahiro Einama, Hirofumi Kamachi, Akinobu Taketomi
BACKGROUND AND OBJECTIVES: This study aimed to evaluate the impact of huge (≥10 cm) hepatocellular carcinoma (HCC) to the recurrence pattern and the prognosis after hepatectomy. METHODS: 574 patients who underwent hepatectomy by 17 surgeons (Open 536 and Laparoscopic 38) for HCC without major vascular invasion from 1990 to 2013 at single institute were retrospectively analyzed. RESULTS: Huge tumor, age, HCV, multiple tumors and microscopic portal invasion are independent risk factors for overall survival (OS), and huge tumor, ICGR15 ≥16%, multiple tumors, moderate/poor histology, microscopic portal invasion and a positive pathological margin are risk factors for relapse-free survival (RFS)...
March 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28182353/prognostic-value-of-ki67-expression-for-patients-with-surgically-resected-hepatocellular-carcinoma-perspectives-from-a-high-incidence-area
#13
Kai Bai, Yi Cao, Qiaojia Huang, Yi Jiang, Lizhi Lv
BACKGROUND: Antigen Ki-67 (Ki67) is a documented tumor biomarker known to be aberrantly expressed in many human cancers. However, to our knowledge, its prognostic value for surgically resected hepatocellular carcinoma (HCC) for high incidence areas of China has not been described. METHODS: We retrospectively investigated 339 patients with HCC who underwent surgery to remove the primary cancer at one center in Fujian, China, an area with a high incidence of HCC from 2004 to 2012...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28182337/serum-insulin-like-growth-factor-1-igf-1-a-novel-prognostic-factor-for-early-recurrence-of-hepatocellular-carcinoma-hcc
#14
Yifan Yao, Weilin Mao, Minya Dong, Donglei Yang, Wenpeng Li, Yu Chen
BACKGROUND: Early recurrence within 1 year is the leading cause of early death in patients with hepatocellular carcinoma (HCC) after liver resection. Circulating levels of insulin-like growth factor-1 (IGF-1) reflect the liver function and prognosis of patients with HCC. In the present study, we aimed to evaluate whether baseline and dynamic changes in serum IGF-1 were associated with early recurrence in patients with HCC who underwent liver resection. METHODS: A total of 144 HCC patients who underwent liver resection were included in this study...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28181486/high-expression-of-akr1b10-predicts-low-risk-of-early-tumor-recurrence-in-patients-with-hepatitis-b-virus-related-hepatocellular-carcinoma
#15
Yan-Yan Wang, Lu-Nan Qi, Jian-Hong Zhong, Hong-Gui Qin, Jia-Zhou Ye, Shi-Dong Lu, Liang Ma, Bang-De Xiang, Le-Qun Li, Xue-Mei You
To clarify the relationship between aldo-keto reductase family 1 member B10 (AKR1B10) expression and early hepatocellular carcinoma (HCC) recurrence, this study detected AKR1B10 expression in tumor and adjacent non-tumor tissues from 110 patients with hepatitis B virus (HBV)-related HCC underwent liver resection and analyzed its correlations with clinicopathological characteristics and prognosis of these patients. Detected by quantitative reverse transcription polymerase chain reaction, AKR1B10 mRNA expression showed significantly higher in HCC tissues than in adjacent non-tumor tissues, with a low level in normal liver tissues...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28159835/mir-135a-5p-mediated-downregulation-of-protein-tyrosine-phosphatase-receptor-delta-is-a-candidate-driver-of-hcv-associated-hepatocarcinogenesis
#16
Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger
BACKGROUND AND AIMS: HCV infection is a leading risk factor of hepatocellular carcinoma (HCC). However, even after viral clearance, HCC risk remains elevated. HCV perturbs host cell signalling to maintain infection, and derailed signalling circuitry is a key driver of carcinogenesis. Since protein phosphatases are regulators of signalling events, we aimed to identify phosphatases that respond to HCV infection with relevance for hepatocarcinogenesis. METHODS: We assessed mRNA and microRNA (miRNA) expression profiles in primary human hepatocytes, liver biopsies and resections of patients with HCC, and analysed microarray and RNA-seq data from paired liver biopsies of patients with HCC...
February 3, 2017: Gut
https://www.readbyqxmd.com/read/28147320/association-of-vegfa-polymorphisms-with-susceptibility-and-clinical-outcome-of-hepatocellular-carcinoma-in-a-chinese-han-population
#17
Fei Liu, Limei Luo, Yonggang Wei, Wentao Wang, Tianfu Wen, Jiayin Yang, Mingqing Xu, Bo Li
Vascular endothelial growth factor A (VEGFA) is an important angiogenesis regulator, which plays an important role in angiogenesis and progression of tumor, including hepatocellular carcinoma (HCC). We aimed at determining whether single nucleotide polymorphisms of VEGFA gene influence the development and clinical outcomes of HCC. We analyzed four potential functional polymorphisms (936C/T, 634G/C, 1612G/A, 2578C/A) of VEGFA gene in 476 HCC patients and 526 controls using matrix-assisted laser desorption ionization time-of-flight mass spectrometry method...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28124000/preoperative-prognostic-values-of-%C3%AE-fetoprotein-afp-and-protein-induced-by-vitamin-k-absence-or-antagonist-ii-pivka-ii-in-patients-with-hepatocellular-carcinoma-for-living-donor-liver-transplantation
#18
Seok-Hwan Kim, Deok-Bog Moon, Wan-Joon Kim, Woo-Hyoung Kang, Jae Hyun Kwon, Eun Kyung Jwa, Hwui-Dong Cho, Su-Min Ha, Yong-Kyu Chung, Sung-Gyu Lee
BACKGROUND: Adult living donor liver transplantation (LDLT) is one of the best treatments for hepatocellular carcinoma (HCC). However, when recurrence of HCC after LDLT occurs, the prognosis is poor because of rapid progression. Preoperative level of α-fetoprotein (AFP) and protein induced by vitamin K antagonist-II (PIVKA-II) reportedly correlate with recurrence of HCC after LDLT. METHODS: We examined AFP and PIVKA-II preoperatively as predictors of HCC recurrence in 461 patients who underwent LDLT using right liver graft for HCC from May 2007 to December 2013...
December 2016: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28123725/assessing-the-feasibility-of-clinicopathological-features-of-hepatic-resection-for-hepatocellular-carcinoma-in-patients-over-80-years-of-age
#19
Hiroya Iida, Masaki Kaibori, Kosuke Matsui, Morihiko Ishizaki, Masanori Kon
The aim of the present study was to evaluate the clinicopathological features, benefits and problems associated with hepatic resection of hepatocellular carcinoma in patients aged ≥80 years. Between 2006 and 2013, hepatic resection was performed in 395 hepatocellular carcinoma patients, including 351 patients aged <80 years and 44 patients aged ≥80 years. Clinicopathological examination revealed that the tumor size was significantly larger among patients of ≥80 years of age. However, recurrence-free and cumulative survival rates were similar between the two age groups...
January 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28114226/predictive-value-of-18f-fdg-pet-ct-for-vascular-invasion-in-patients-with-hepatocellular-carcinoma-before-liver-transplantation
#20
Chun-Yi Lin, Chiung-Wei Liao, Lu-Yen Chu, Kuo-Yang Yen, Long-Bin Jeng, Cheng-Nan Hsu, Cheng-Li Lin, Chia-Hung Kao
BACKGROUND: Positron emission tomography-computed tomography using F-fluorodeoxyglucose (F-FDG PET/CT) has been widely used in oncology. Vascular invasion of hepatocellular carcinoma (HCC) is associated with a high risk of tumor recurrence and low survival rates after liver transplantation (LT). This retrospective study determined the predictive value of F-FDG PET/CT for vascular invasion in patients with HCC before LT. METHODS: Sixty-five patients with HCC who underwent F-FDG PET/CT before LT were retrospectively included between January 2010 and July 2012...
January 20, 2017: Clinical Nuclear Medicine
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