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recurrent risk factors hepatocellular carcinoma

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https://www.readbyqxmd.com/read/28718980/an-endogenous-dna-adduct-as-a-prognostic-biomarker-for-hepatocarcinogenesis-and-its-prevention-by-theaphenon-e-in-mice
#1
Ying Fu, Shana Silverstein, Justine N McCutcheon, Marcin Dyba, Raghu G Nath, Monika Aggarwal, Heidi Coia, Angela Bai, Jishen Pan, Jiji Jiang, Bhaskar Kallakury, Hongkun Wang, Yu-Wen Zhang, Giuseppe Giaccone, Aiwu Ruth He, Fung-Lung Chung
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, mainly because of its poor prognosis. A valid mechanism-based prognostic biomarker is urgently needed. γ-hydroxy-1,N(2) -propanodeoxyguanosine (γ-OHPdG) is an endogenously formed mutagenic DNA adduct derived from lipid peroxidation (LPO). We examined the relationship of γ-OHPdG with hepatocarcinogenesis in two animal models and its potential role as a prognostic biomarker for recurrence in HCC patients. Bioassays were conducted in the Xeroderma pigmentosum group A knockout mice (Xpa(-/-) ), and the diethylnitrosamine (DEN)-injected mice, both prone to HCC development...
July 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28717870/laparoscopic-liver-resections-for-hepatocellular-carcinoma-can-we-extend-the-surgical-indication-in-cirrhotic-patients
#2
Federica Cipriani, Corrado Fantini, Francesca Ratti, Roberto Lauro, Hadrien Tranchart, Mark Halls, Vincenzo Scuderi, Leonid Barkhatov, Bjorn Edwin, Roberto I Troisi, Ibrahim Dagher, Paolo Reggiani, Giulio Belli, Luca Aldrighetti, Mohammad Abu Hilal
BACKGROUND: Evidence on the value of laparoscopic liver resections (LLR) for hepatocellular carcinoma (HCC) and severe cirrhosis is still lacking. The aim of this study is to assess surgical and oncological outcomes of LLR in cirrhotic HCC patients. METHODS: The analysis included 403 LLR for HCC from seven European centres. 333 cirrhotic and 70 non-cirrhotic patients were compared. A matched comparison was performed between 100 Child-Pugh A and 25 Child-Pugh B patients...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28711925/prediction-of-early-recurrence-of-hepatocellular-carcinoma-within-the-milan-criteria-after-radical-resection
#3
Jiliang Feng, Junmei Chen, Ruidong Zhu, Lu Yu, Yan Zhang, Dezhao Feng, Heli Kong, Chenzhao Song, Hui Xia, Jushan Wu, Dawei Zhao
Approximately 50% hepatocellular carcinoma patients meeting the Milan criteria utilized to develop an improved prognostic model for predicting the recurrence in these patients. Using univariate and multivariate analysis, cytokeratin-19 and glypican-3 expression patterns, tumor number and histological grading from eight putative prognostic factors comprised the risk factor scoring model to predict the tumor recurrence. In the training cohort, the area under roc curve (AUC) value of the model was 0.715 [95% confidence interval (CI) = 0...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28705491/proposal-of-selection-criteria-for-operative-resection-of-hepatocellular-carcinoma-with-inferior-vena-cava-tumor-thrombus-incorporating-hepatic-arterial-infusion-chemotherapy
#4
Yosuke Kasai, Etsuro Hatano, Satoru Seo, Kojiro Taura, Kentaro Yasuchika, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
BACKGROUND: Because operative resection of hepatocellular carcinoma with inferior vena cava tumor thrombus has been associated with a substantial risk of recurrence and postoperative morbidity, adequate patient selection for resection is necessary. Our aim was to propose selection criteria for resection of hepatocellular carcinoma with inferior vena cava tumor thrombus. METHODS: Long-term outcomes were analyzed retrospectively in 39 operative cases of hepatocellular carcinoma with inferior vena cava tumor thrombus (1996-2015)...
July 10, 2017: Surgery
https://www.readbyqxmd.com/read/28696046/survival-impacts-of-lymphocyte-infiltration-into-the-tumor-of-hepatocellular-carcinoma-in-hbv-positive-or-non-b-non-c-patients-who-underwent-curative-resection
#5
Shigeki Nakagawa, Naoki Umezaki, Takanobu Yamao, Takayoshi Kaida, Hirohisa Okabe, Kosuke Mima, Katsunori Imai, Daisuke Hashimoto, Yo-Ichi Yamashita, Takatoshi Ishiko, Akira Chikamoto, Hideo Baba
AIM: The prognostic value of lymphocyte infiltration into hepatocellular carcinoma (HCC) is still controversial, and it has not been reported in HBV- and non-B non-C HCC. The aim of this study is to assess the prognostic significance of lymphocyte infiltrate in tumor for the patients of HBV positive and non-B non-C (NBNC) HCC patients. METHODS: This study investigated 145 HBV positive or NBNC patients who underwent hepatectomy for HCC between January 2001 and May 2009...
July 11, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28679433/long-term-survival-of-hepatocellular-carcinoma-after-percutaneous-radiofrequency-ablation-guided-by-ultrasound
#6
Weimin Zhang, Erping Luo, Jianhe Gan, Xiaomin Song, Zuowei Bao, Huiping Zhang, Minhua Chen
BACKGROUND: The risk factors for recurrence and death after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) remain poorly known. This study was aimed to study the 10-year overall survival (OS) of HCC treated by ultrasound (US)-guided RFA and the risk factors for recurrence and death. METHODS: Between June 2005 and June 2016, 1000 patients with HCC treated by US-guided RFA at 4 hospitals in China; among them, 525 patients met the criteria for radical ablation and 410 had high AFP levels before RFA treatment...
July 5, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28654545/impact-of-pretransplant-bridging-locoregional-therapy-for-patients-with-hepatocellular-carcinoma-within-milan-criteria-undergoing-liver-transplantation-analysis-of-3601-patients-from-the-us-multicenter-hcc-transplant-consortium
#7
Vatche G Agopian, Michael P Harlander-Locke, Richard M Ruiz, Goran B Klintmalm, Srinath Senguttuvan, Sander S Florman, Brandy Haydel, Maarouf Hoteit, Matthew H Levine, David D Lee, C Burcin Taner, Elizabeth C Verna, Karim J Halazun, Rita Abdelmessih, Amit D Tevar, Abhinav Humar, Federico Aucejo, William C Chapman, Neeta Vachharajani, Mindie H Nguyen, Marc L Melcher, Trevor L Nydam, Constance Mobley, R Mark Ghobrial, Beth Amundsen, James F Markmann, Alan N Langnas, Carol A Carney, Jennifer Berumen, Alan W Hemming, Debra L Sudan, Johnny C Hong, Joohyun Kim, Michael A Zimmerman, Abbas Rana, Michael L Kueht, Christopher M Jones, Thomas M Fishbein, Ronald W Busuttil
OBJECTIVE: To evaluate the effect of pretransplant bridging locoregional therapy (LRT) on hepatocellular carcinoma (HCC) recurrence and survival after liver transplantation (LT) in patients meeting Milan criteria (MC). SUMMARY BACKGROUND DATA: Pre-LT LRT mitigates tumor progression and waitlist dropout in HCC patients within MC, but data on its impact on post-LT recurrence and survival remain limited. METHODS: Recurrence-free survival and post-LT recurrence were compared among 3601 MC patients with and without bridging LRT utilizing competing risk Cox regression in consecutive patients from 20 US centers (2002-2013)...
June 26, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28651644/a-new-use-for-an-old-index-preoperative-high-density-lipoprotein-predicts-recurrence-in-patients-with-hepatocellular-carcinoma-after-curative-resections
#8
Lu Tian, Qian Yu, Xing-Hui Gao, Jiong Wu, Xiao-Lu Ma, Qian Dai, Chun-Yan Zhang, Yan Zhou, Yi-Chi Zhang, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
BACKGROUND: Hepatocellular carcinoma has high incidence and mortality worldwide. Liver is the site of most metabolic biotransformation, which could reflect the status of cells. Most plasma apolipoproteins, endogenous lipids and lipoproteins are synthesized in the liver. Therefore, the effects of lipid metabolites on prognosis of HCC deserved to be explored. METHODS: We prospectively included 58 healthy donors (HD), 50 chronic hepatitis (CH) patients and a training cohort of 189 patients with HCC who underwent curative resections at Zhongshan Hospital from January 2012 to August 2012...
June 26, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28650354/prediction-of-hepatocellular-carcinoma-recurrence-beyond-milan-criteria-after-resection-validation-of-a-clinical-risk-score-in-an-international-cohort
#9
Jian Zheng, Joanne F Chou, Mithat Gönen, Neeta Vachharajani, William C Chapman, Maria B Majella Doyle, Simon Turcotte, Franck Vandenbroucke-Menu, Réal Lapointe, Stefan Buettner, Bas Groot Koerkamp, Jan N M Ijzermans, Chung Yip Chan, Brian K P Goh, Jin Yao Teo, Juinn Huar Kam, Prema R Jeyaraj, Peng Chung Cheow, Alexander Y F Chung, Pierce K H Chow, London L P J Ooi, Vinod P Balachandran, T Peter Kingham, Peter J Allen, Michael I D'Angelica, Ronald P DeMatteo, William R Jarnagin, Ser Yee Lee
OBJECTIVE: This study aims to validate a previously reported recurrence clinical risk score (CRS). SUMMARY OF BACKGROUND DATA: Salvage transplantation after hepatocellular carcinoma (HCC) resection is limited to patients who recur within Milan criteria (MC). Predicting recurrence patterns may guide treatment recommendations. METHODS: An international, multicenter cohort of R0 resected HCC patients were categorized by MC status at presentation...
July 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28639906/preoperative-platelet-to-lymphocyte-ratio-is-a-valuable-prognostic-biomarker-in-patients-with-hepatocellular-carcinoma-undergoing-curative-liver-resection
#10
Hao-Jie Yang, Jing-Hang Jiang, Qing-An Liu, Cheng-Mao Zhou, Yang-Feng Du, Tao Wu, Neng-Zhi Chen, Bang-De Xiang
The Platelet to lymphocyte ratio (PLR) has been reported to predict prognosis of patients with hepatocellular carcinoma (HCC). This study examined the prognostic potential of stratified PLR for HCC patients undergoing curative liver resection. Medical records were retrospectively analyzed for 778 HCC patients undergoing curative liver resection at the Affiliated Tumor Hospital of Guangxi Medical University and the First People's Hospital of Changde between April 2010 and October 2013. Patients were stratified based on quintile analysis of their preoperative PLR, and patients in different quintiles were analyzed for overall survival (OS) and disease-free survival (DFS) using Kaplan-Meier analysis...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28634055/an-insight-on-the-association-of-glycation-with-hepatocellular-carcinoma
#11
REVIEW
Nasimudeen R Jabir, Saheem Ahmad, Shams Tabrez
Hepato-cellular carcinoma (HCC) is one of the frequent cause of cancer-related death worldwide and dominant form of primary liver cancer. However, the reason behind a steady increase in the incidence of this form of cancer remains elusive. Glycation has been reported to play a significant role in the induction of several chronic diseases including cancer. Several risk factors that could induce HCC have been reported in the literature. Deciphering the complex patho-physiology associated with HCC is expected to provide new targets for the early detection, prevention, progression and recurrence...
June 17, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28628564/risk-of-post-transplant-hepatocellular-carcinoma-recurrence-is-higher-in-recipients-of-livers-from-male-than-female-living-donors
#12
Sangbin Han, Ju Dong Yang, Dong Hyun Sinn, Jong Man Kim, Gyu Sung Choi, Gangha Jung, Joong Hyun Ahn, Seonwoo Kim, Justin S Ko, Mi Sook Gwak, Choon Hyuck D Kwon, Michael D Leise, Geum-Youn Gwak, Julie K Heimbach, Gaab Soo Kim
OBJECTIVE: To evaluate the relationship between donor sex and hepatocellular carcinoma (HCC) recurrence after living donor liver transplantation. BACKGROUND: HCC shows a male predominance in incidence and recurrence after tumor resection due to sex differences in hepatic sex hormone receptors. There have been no studies evaluating the importance of donor sex on post-transplant HCC recurrence. METHODS: Of 384 recipients of livers, from living donors, for HCC: 104/120 who received grafts from female donors were matched with 246/264 who received grafts from male donors using propensity score matching, with an unfixed matching ratio based on factors like tumor biology...
June 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28624108/modification-of-immunosuppressive-therapy-as-risk-factor-for-complications-after-liver-transplantation
#13
REVIEW
Paolo De Simone, Paola Carrai, Laura Coletti, Davide Ghinolfi, Stefania Petruccelli, Franco Filipponi
Management of complications post-liver transplantation (LT) includes immunosuppressive manipulations with the aim to reduce the overall burden of immunologic suppression and compensate for renal, cardiovascular, metabolic toxicities, and for the increased oncologic risk. Two approaches can be implemented to reduce immunosuppression-related adverse events: upfront schedules tailored to the pretransplant individual patient's risk profile versus downstream modifications in the event of immunosuppression-related complications...
April 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28615138/wide-versus-narrow-margins-after-partial-hepatectomy-for-hepatocellular-carcinoma-balancing-recurrence-risk-and-liver-function
#14
Wesley B S Field, Jack W Rostas, Prejesh Philps, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
BACKGROUND: The goal of this study was to compare the outcome after partial hepatectomy for hepatocellular carcinoma (HCC) in which a margin less than or equal to 5 mm or greater than 5 mm was achieved. METHODS: A review of our 3300-patient prospective HPB database was performed from 12/2002 to 4/2015. Patients were stratified into two groups: resection margins ≤5 ("narrow") and >5 mm ("wide") as measured on final pathologic assessment. RESULTS: One-hundred thirty patients were included in the analysis (margin ≤5 mm, n = 41 and margin >5 mm, n = 89)...
June 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28603096/patients-with-early-recurrence-of-hepatocellular-carcinoma-have-poor-prognosis
#15
Tomoki Kobayashi, Hiroshi Aikata, Tsuyoshi Kobayashi, Hideki Ohdan, Koji Arihiro, Kazuaki Chayama
BACKGROUND: Early recurrence (ER) after hepatic resection (HR) is a poor prognostic factor for patients with hepatocellular carcinoma (HCC). This study aimed to identify the clinicopathological features, outcomes, and risk factors for ER after HR for small HCC in order to clarify the reasons why ER is a worse recurrence pattern. METHODS: We retrospectively examined 130 patients who underwent HR for small HCC (≤30 mm). Recurrence was classified into ER (<2 years) and late recurrence (LR) (≥2 years)...
June 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28599412/dna-topoisomerase-ii%C3%AE-and-ki67-are-prognostic-factors-in-patients-with-hepatocellular-carcinoma
#16
Yi Cao, Ruisheng Ke, Shaohu Wang, Xu Zhu, Jianwei Chen, Chao Huang, Yi Jiang, Lizhi Lv
The present study was designed to determine the significance of DNA topoisomerase IIa (TopoIIα) and Ki67 in hepatocellular carcinoma cells (HCCs). The present study included 353 patients with HCC. The association of clinicopathological data with the expression of TopoIIα and Ki67 by immunohistochemistry was analyzed by χ(2) test. Cox multivariate proportional hazards regression analysis and Kaplan-Meier analysis were performed with all the variables to derive risk estimates associated with overall survival (OS)/recurrence-free survival (RFS) and to control for confounders...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28591740/prognostic-value-and-preoperative-predictors-of-microvascular-invasion-in-solitary-hepatocellular-carcinoma-%C3%A2-5-cm-without-macrovascular-invasion
#17
Hui Zhao, Ye Hua, Zhihua Lu, Shen Gu, Laifa Zhu, Yuan Ji, Yudong Qiu, Tu Dai, Huihan Jin
OBJECTIVES: The aim of this study was to investigate the prognostic value and preoperative predictors of microvascular invasion (MVI) in solitary hepatocellular carcinoma (HCC) ≤ 5 cm without macrovascular invasion. METHODS: A total of 233 consecutive HCC patients underwent curative hepatectomy were included in our study. Independent risk factors influencing the prognosis were identified, and preoperative predictors for MVI were determined. RESULTS: Multivariate regression analysis identified ICG-R15, BCLC staging and MVI as independent risk factors for the overall survival rate...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28589639/significance-of-presence-of-microvascular-invasion-in-specimens-obtained-after-surgical-treatment-of-hepatocellular-carcinoma
#18
REVIEW
Xiaofeng Zhang, Jun Li, Feng Shen, Wan Yee Lau
Partial hepatectomy and liver transplantation are potentially curative treatments in selected patients with hepatocellular carcinoma (HCC). Unfortunately, a high postoperative tumor recurrence rate significantly decreases long-term survival outcomes. Among multiple prognostic factors, the presence of microvascular invasion (MVI) has increasingly been recognized to reflect enhanced abilities of local invasion and distant metastasis of HCC. Unfortunately, MVI can only currently be identified through histopathological studies on resected surgical specimens...
June 6, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28583823/regulator-of-calcineurin-1-gene-isoform-4-down-regulated-in-hepatocellular-carcinoma-prevents-proliferation-migration-and-invasive-activity-of-cancer-cells-and-growth-of-orthotopic-tumors-by-inhibiting-nuclear-translocation-of-nfat1
#19
Haojie Jin, Cun Wang, Guangzhi Jin, Haoyu Ruan, Dishui Gu, Lin Wei, Hui Wang, Ning Wang, Einthavy Arunachalam, Yurong Zhang, Xuan Deng, Chen Yang, Yi Xiong, Hugang Feng, Ming Yao, Jingyuan Fang, Jianren Gu, Wenming Cong, Wenxin Qin
BACKGROUND & AIMS: Individuals with Down syndrome have a low risk for many solid tumors, prompting the search for tumor suppressor genes on human chromosome 21 (HSA21). We aimed to identify and explore potential mechanisms of suppressors on HSA21 in hepatocellular carcinoma (HCC). METHODS: We compared expression of HSA21 genes in 14 pairs of primary HCC and adjacent noncancer liver tissue using the Affymetrix HG-U133 Plus 2.0 array (Affymetrix, Santa Clara, CA)...
June 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28583536/primary-living-donor-liver-transplantation-is-not-the-optimal-treatment-choice-in-patients-with-early-hepatocellular-carcinoma-with-poor-tumor-biology
#20
M-S Park, K-W Lee, H Kim, Y R Choi, G Hong, N-J Yi, K-S Suh
OBJECTIVE: Liver resection (LR) and living-donor liver transplantation (LDLT) are considered the two potentially curative treatments for hepatocellular carcinoma (HCC). The aim of this study was to investigate whether there is a difference in the oncologic outcomes between LR and LDLT according to tumor biology. METHODS: Patients (137 LDLTs and 199 LRs) were stratified into four groups by tumor biology according to the number of risk factors for recurrence (preoperative alpha-fetoprotein >200 ng/mL, Edmonson grade 3 or 4, tumor size >3 cm, and presence of microvascular invasion)...
June 2017: Transplantation Proceedings
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