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recurrent risk factors hepatocellular carcinoma

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https://www.readbyqxmd.com/read/27923614/antiviral-therapy-inhibits-viral-reactivation-and-improves-survival-after-repeat-hepatectomy-for-hepatitis-b-virus-related-recurrent-hepatocellular-carcinoma
#1
Shengyu Huang, Yong Xia, Zhengqing Lei, Qifei Zou, Jun Li, Tian Yang, Kui Wang, Zhenlin Yan, Xuying Wan, Feng Shen
BACKGROUND: To explore the impact of antiviral therapy (AVT) on short- and long-term outcomes after re-hepatectomy for patients with recurrent HBV-related hepatocellular carcinoma (HCC). STUDY DESIGN: The data of 583 consecutive patients who underwent re-hepatectomy for intrahepatic recurrence of HBV-related HCC after initial hepatectomy between 2006 and 2011 at the Eastern Hepatobiliary Surgery Hospital were analyzed. Tumor re-recurrence, recurrence to death survival (RTDS) and overall survival (OS) were compared using the Kaplan-Meier method and log-rank test...
December 3, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27916167/post-resection-recurrence-of-hepatocellular-carcinoma-in-cirrhotic-patients-is-thrombocytopenia-a-risk-factor-for-recurrence
#2
Ahmed Shehta, Ho-Seong Han, Soyeon Ahn, Yoo-Seok Yoon, Jai Young Cho, Young Rok Choi
PURPOSE: Liver resection is the main treatment for hepatocellular carcinoma (HCC) patients with sufficient liver reserve. However, the long-term outcomes are dismal because the recurrence rate is high, especially in cirrhotic patients. The role of platelets as a predictive factor for HCC recurrence is still controversial. The aim of this study was to assess the influence of the preoperative platelet count on HCC recurrence after liver resection in patients with liver cirrhosis. STUDY DESIGN: Between 2004 and 2013, 233 HCC patients with pathologically proven liver cirrhosis underwent liver resection and were enrolled in this study...
December 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27896409/post-resection-prognosis-of-combined-hepatocellular-carcinoma-cholangiocarcinoma-according-to-the-2010-who-classification
#3
Dong-Hwan Jung, Shin Hwang, Seung-Mo Hong, Yong-Kyu Chung, Gi-Won Song, Young-Joo Lee, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gil-Chun Park, Han Chu Lee, Young-Suk Lim, Eun Sil Yu, Sung-Gyu Lee
BACKGROUND: Combined hepatocellular carcinoma and cholangiocarcinoma (cHC) has wide histological diversity. We intended to investigate the prognostic influence of tumor types of cHC. METHODS: We analyzed the clinical and pathological features of cHC along 2010 WHO classification. Study group was 100 cHC patients who underwent primary resection. Control group comprised 200 propensity score-matched patients with intrahepatic cholangiocarcinoma (ICC). RESULTS: In cHC group, tumor diameter was 4...
November 28, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27894667/nuclear-pkm2-expression-an-independent-risk-factor-for-er-after-curative-resection-of-hepatocellular-carcinoma
#4
Fangtian Fan, Hongyan Wu, Zhaoguo Liu, Xianbang Hou, Wenxin Chen, Aiyun Wang, Yin Lu
Surgical resection, providing a long-term survival of hepatocellular carcinoma (HCC) patients, is regarded as one of the standard curative treatments of HCC if the tumor is resectable. However, 50% patients develop early recurrence (ER) during the first two years after operation, which are more diffuse and rarely treatable with unsatisfactory long-term survival. Unfortunately, the underlying mechanisms of ER after curative resection and the molecular markers with predictive and prognostic significance have never been identified yet...
November 25, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27882419/pleural-effusion-after-hepatectomy-for-hepatocellular-carcinoma-risk-factor-analyses-and-its-impact-on-oncological-outcomes
#5
Hideaki Uchiyama, Norifumi Harimoto, Shinji Itoh, Tomoharu Yoshizumi, Toru Ikegami, Yoshihiko Maehara
BACKGROUND: Although posthepatectomy pleural effusion (PHPE) is a commonly observed phenomenon, its precise etiology and the impact of its emergence on oncological outcomes have still unknown. The aim of the current study was to retrospectively investigate risk factors for PHPE and its impact on oncological outcomes of hepatocellular carcinoma (HCC). METHODS: Medical records of 330 patients who underwent primary curative hepatectomy for HCC were reviewed. All 330 patients had CT around day 7 after hepatectomy, and the emergence of PHPE on CT was examined...
November 23, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27872682/prophylactic-liver-transplantation-for-high-risk-recurrent-hepatocellular-carcinoma
#6
REVIEW
Po-Chih Yang, Cheng-Maw Ho, Rey-Heng Hu, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. Radical treatment of HCC in early stages results in a long disease-free period and improved overall survival. The choice of optimal management strategy for HCC mainly depends on the severity of the underlying liver disease. For patients with decompensated liver cirrhosis and HCC within Milan criteria (MC), liver transplant (LT) is the choice of treatment. However, for patients with good residual liver reserve and HCC within MC, selection of other curative treatments such as liver resection (LR) or radiofrequency ablation may be a reasonable alternative...
November 8, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27818858/prognosis-for-recipients-with-hepatocellular-carcinoma-of-salvage-liver-transplantation-versus-those-of-primary-liver-transplantation-a-retrospective-single-center-study
#7
Pusen Wang, Ying Pu, Hao Li, Baojie Shi, Shengnai Zheng, Lin Zhong
PURPOSE: The prognosis for recipients with hepatocellular carcinoma (HCC) of salvage liver transplantation (SLT) versus those of primary liver transplantation (PLT) remains controversial. The objective of this study was to evaluate the clinical features and survival rate of SLT recipients. METHODS: Three hundred seventy-one patients with HCC transplanted at Shanghai General Hospital, China, between October 2001 and October 2011 were separated into PLT (n = 295) and SLT (n = 76) groups...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27815759/distinct-recurrence-risk-factors-for-intrahepatic-metastasis-and-multicenter-occurrence-after-surgery-in-patients-with-hepatocellular-carcinoma
#8
Shenghua Hao, Ping Fan, Shaofei Chen, Caixue Tu, Chidan Wan
BACKGROUND AND OBJECTIVES: Intrahepatic recurrence after hepatectomy for hepatocellular carcinoma (HCC) includes intrahepatic metastasis (IM) and multicenter occurrence (MO). The risk factors for these two types of intrahepatic recurrence have not been well defined. METHODS: The type of intrahepatic recurrence was determined based on histopathological features of 93 HCC patients who underwent a repeat hepatectomy for recurrent HCC. Various clinical and pathological factors were analyzed to define distinct risk factors for different types of intrahepatic recurrence...
November 4, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27806426/significance-of-preoperative-fluorodeoxyglucose-positron-emission-tomography-in-prediction-of-tumor-recurrence-after-liver-transplantation-for-hepatocellular-carcinoma-patients-a-japanese-multicenter-study
#9
Yasutsugu Takada, Toshimi Kaido, Ken Shirabe, Hiroaki Nagano, Hiroto Egawa, Yasuhiko Sugawara, Akinobu Taketomi, Takeshi Takahara, Go Wakabayashi, Chikashi Nakanishi, Naoki Kawagishi, Akira Kenjo, Mitsukazu Gotoh, Yoshikazu Toyoki, Kenichi Hakamada, Masayuki Ohtsuka, Nobuhisa Akamatsu, Norihiro Kokudo, Kazuhisa Takeda, Itaru Endo, Hiroyuki Takamura, Hideaki Okajima, Hiroshi Wada, Shoji Kubo, Kaoru Kuramitsu, Yonson Ku, Kohei Ishiyama, Hideki Ohdan, Eitaro Ito, Yoshihiko Maehara, Masaki Honda, Yukihiro Inomata, Hiroyuki Furukawa, Shinji Uemoto, Hiroki Yamaue, Masaru Miyazaki, Tadahiro Takada
BACKGROUND/AIMS: In the present study, we conducted a multicenter nationwide survey to investigate the effects of preoperative fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the prediction of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). METHODS: From 16 Japanese LT centers, data were collected on 182 recipients with HCC who underwent living donor liver transplantation (LDLT) between February 2005 and November 2013...
November 2, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27798927/inflammation-based-prognostic-score-in-patients-with-living-donor-liver-transplantation-for-hepatocellular-carcinoma
#10
Norifumi Harimoto, Tomoharu Yoshizumi, Tomonari Shimagaki, Akihisa Nagatsu, Takashi Motomura, Noboru Harada, Hirohisa Okabe, Shinji Itoh, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Inflammation-besed prognostic score including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies. PATIENTS AND METHODS: We retrospectively investigated their prognostic value in 213 patients with living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Disease-free survival (DFS) following LDLT was calculated; NLR, PLR, PNI and mGPS values in patients with and without recurrence were compared...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27787908/presence-of-non-hypervascular-hypointense-nodules-on-gd-eob-dtpa-enhanced-mri-in-patients-with-hepatocellular-carcinoma
#11
Masanori Inoue, Sadahisa Ogasawara, Tetsuhiro Chiba, Yoshihiko Ooka, Toru Wakamatsu, Kazufumi Kobayashi, Eiichiro Suzuki, Akinobu Tawada, Osamu Yokosuka
BACKGROUND AND AIMS: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) performed before curative therapy for hepatocellular carcinoma (HCC) can distinguish between intrahepatic distant recurrence and hypervascularization. We aimed to retrospectively evaluate the presence of non-hypervascular hypointense nodules on hepatobiliary phase images (HBPI) from Gd-EOB-DTPA-enhanced MRI as a risk factor of the intrahepatic distant recurrence of early-stage HCC following radiofrequency ablation (RFA)...
October 27, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27771158/incidence-and-risk-factors-of-hepatocellular-carcinoma-after-orthotopic-liver-transplantation
#12
E Dudley Colhoun, C Gunnar Forsberg, Kenneth D Chavin, Prabhakar K Baliga, David J Taber
BACKGROUND: The incidence of hepatocellular carcinoma has doubled over the past 2 decades, becoming the fifth most common cancer worldwide. Orthotopic liver transplant is the gold standard treatment for those with hepatocellular carcinoma meeting eligibility criteria, although recurrence rates of hepatocellular carcinoma after orthotopic liver transplant still remain an understudied obstacle. METHODS: We performed a single-center, retrospective, longitudinal study with the aim of determining the predominant baseline and follow-up variables associated with hepatocellular carcinoma recurrence...
October 19, 2016: Surgery
https://www.readbyqxmd.com/read/27748052/irregular-vascular-pattern-by-contrast-enhanced-ultrasonography-and-high-serum-lens-culinaris-agglutinin-reactive-fraction-of-alpha-fetoprotein-level-predict-poor-outcome-after-successful-radiofrequency-ablation-in-patients-with-early-stage-hepatocellular-carcinoma
#13
Hitomi Takada, Kaoru Tsuchiya, Yutaka Yasui, Natsuko Nakakuki, Nobuharu Tamaki, Shoko Suzuki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Yasuhiro Asahina, Nobuyuki Enomoto, Namiki Izumi
Radiofrequency ablation (RFA) is considered the most effective treatment for early-stage hepatocellular carcinoma (HCC) patients unsuitable for resection. However, poor outcome after RFA has occasionally been reported worldwide. To predict such an outcome, we investigated imaging findings using contrast-enhanced ultrasonography (CEUS) with Sonazoid and serum tumor markers before RFA. This study included 176 early-stage HCC patients who had initially achieved successful RFA. Patients were examined using CEUS; their levels of alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and des-gamma-carboxy prothrombin before RFA were measured...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27743138/novel-microvascular-invasion-based-prognostic-nomograms-to-predict-survival-outcomes-in-patients-after-r0-resection-for-hepatocellular-carcinoma
#14
Long-Hai Feng, Hui Dong, Wan-Yee Lau, Hua Yu, Yu-Yao Zhu, Yun Zhao, Yu-Xi Lin, Jia Chen, Meng-Chao Wu, Wen-Ming Cong
PURPOSE: To propose a novel histopathological classification system for microvascular invasion (MVI) and to establish nomograms to predict postoperative survival and early tumor recurrence in patients with hepatocellular carcinoma (HCC) after R0 liver resection. METHODS: The clinicopathological and follow-up data of 686 consecutive patients with HCC who underwent R0 liver resection in our hospital between December 2009 and April 2010 were retrospectively reviewed...
October 14, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27742104/radiofrequency-ablation-and-transarterial-chemoembolisation-as-first-line-treatment-for-recurrent-hepatocellular-carcinoma-or-isolated-intrahepatic-recurrent-hepatocellular-carcinoma-in-transplanted-livers
#15
S S Kim, T W Kang, K D Song, S K Cho, M W Lee, H Rhim, D H Sinn, S-H Jung
AIM: To evaluate the efficacy of radiofrequency ablation (RFA) and transarterial chemoembolisation (TACE) as a first-line treatment for isolated intrahepatic recurrent hepatocellular carcinoma (IIR-HCC) after liver transplantation (LT). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board. Between January 2005 and January 2015, 588 consecutive patients underwent LT for the treatment of HCC. Among them, 27 patients with IIR-HCCs after LT who were treated with RFA (n=6) or TACE (n=21) as a first-line treatment were retrospectively included in this study...
October 11, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27730399/elevated-serum-carcinoembryonic-antigen-is-associated-with-a-worse-survival-outcome-of-patients-after-liver-resection-for-hepatocellular-carcinoma-a-propensity-score-matching-analysis
#16
Jianwei Liu, Yong Xia, Lehua Shi, Xifeng Li, Lu Wu, Zhenlin Yan
BACKGROUND: The relationship between serum carcinoembryonic antigen (CEA) and postoperative prognosis in hepatocellular carcinoma (HCC) has not been reported. METHODS: Data of 5410 consecutive HCC patients who underwent hepatectomy was retrospectively reviewed. Survival curves for overall survival (OS) and tumor recurrence (TR) were depicted using the Kaplan-Meier method and compared using the log-rank test. Independent risk factors of OS and TR were analyzed with Cox hazard regression model...
December 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27729623/prognostic-value-of-a-novel-risk-classification-of-microvascular-invasion-in-patients-with-hepatocellular-carcinoma-after-resection
#17
Hui Zhao, Chuang Chen, Xu Fu, Xiaopeng Yan, Wenjun Jia, Liang Mao, Huihan Jin, Yudong Qiu
OBJECTIVES: The present research aimed to evaluate the prognostic value of a novel risk classification of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) after resection. METHODS: A total of 295 consecutive HCC patients underwent hepatectomy were included in our study. We evaluated the degree of MVI according to the following three features: the number of invaded microvessels (≤5 vs >5), the number of invading carcinoma cells (≤ 50 vs >50), the distance of invasion from tumor edge (≤1 cm vs >1 cm)...
October 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27722159/nash-cirrhosis-the-new-burden-in-liver-transplantation-how-should-it-be-managed
#18
REVIEW
Ali Canbay, Jan-Peter Sowa, Wing-Kin Syn, Jürgen Treckmann
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a continuously increasing cause of chronic liver disease and a health burden in all populations affected by the obesity and metabolic syndrome pandemic. Cirrhotic alterations or hepatocellular carcinoma developing from NAFLD may require liver transplantation (LTx). METHODS: Current literature was screened for data on LTx in the setting of NAFLD. RESULTS: NAFLD-associated LTx is expected to increase in number and relevance during the next decade...
August 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27678133/the-impact-of-clinically-significant-portal-hypertension-on-the-prognosis-of-patients-with-hepatocellular-carcinoma-after-radiofrequency-ablation-a-propensity-score-matching-analysis
#19
Kuan-Chieh Fang, Chien-Wei Su, Yi-You Chiou, Pei-Chang Lee, Nai-Chi Chiu, Chien-An Liu, Ping-Hsien Chen, Wei-Yu Kao, Yi-Hsiang Huang, Teh-Ia Huo, Ming-Chih Hou, Han-Chieh Lin, Jaw-Ching Wu
OBJECTIVES: To assess the impact of clinically significant portal hypertension (CSPH) on the prognosis of patients with hepatocellular carcinoma (HCC) undergoing radiofrequency ablation (RFA). METHODS: We retrospectively enrolled 280 treatment-naïve early-stage HCC patients who had Child-Pugh grade A or B and received upper gastrointestinal endoscopy at the time of HCC diagnosis. CSPH was defined as (1) a platelet count < 100,000/mm(3) associated with splenomegaly and/or (2) the presence of oesophageal/gastric varices by endoscopy...
September 27, 2016: European Radiology
https://www.readbyqxmd.com/read/27673508/effect-of-bridging-local-regional-therapy-on-recurrence-of-hepatocellular-carcinoma-and-survival-after-orthotopic-liver-transplantation
#20
Hayley C Oligane, Minzhi Xing, Hyun S Kim
Purpose To evaluate the influence of bridging local-regional therapy (LRT) on hepatocellular carcinoma (HCC) recurrence and overall survival after orthotopic liver transplantation and to identify factors that predict HCC recurrence after orthotopic liver transplantation. Materials and Methods The United Network for Organ Sharing database was used to identify patients with HCC who underwent liver transplantation between 2002 and 2013. Patients with complete explant data within the Milan criteria for whom a Model for End-Stage Liver Disease exception was approved were retrospectively analyzed...
September 27, 2016: Radiology
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