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Peripheral vascular disease

B M Biccard, A Sigamani, M T V Chan, D I Sessler, A Kurz, J G Tittley, T Rapanos, J Harlock, D Szalay, M E Tiboni, E Popova, S M Vásquez, B Kabon, M Amir, M Mrkobrada, B R Mehra, H El Beheiry, E Mata, B Tena, S Sabaté, M K Zainal Abidin, V R Shah, K Balasubramanian, P J Devereaux
BACKGROUND: In the POISE-2 (PeriOperative ISchemic Evaluation 2) trial, perioperative aspirin did not reduce cardiovascular events, but increased major bleeding. There remains uncertainty regarding the effect of perioperative aspirin in patients undergoing vascular surgery. The aim of this substudy was to determine whether there is a subgroup effect of initiating or continuing aspirin in patients undergoing vascular surgery. METHODS: POISE-2 was a blinded, randomized trial of patients having non-cardiac surgery...
July 18, 2018: British Journal of Surgery
Bruce S Sachais, Beth H Shaz
BACKGROUND: Therapeutic apheresis is a term used to describe a group of treatments where blood components are separated in real time, and one component is removed, exchanged, and/or treated to remove pathogenic substances from the circulation. Plasma exchange, which removed all plasma components, and lipid apheresis which selectively removes lipoproteins from circulation, have both been used to treat atherosclerotic vascular diseases. METHODS: To review the literature regarding the application of therapeutic apheresis for atherosclerotic vascular diseases...
July 16, 2018: American Journal of Hypertension
Kai K Kummer, Theodora Kalpachidou, Miodrag Mitrić, Michiel Langeslag, Michaela Kress
Fabry disease is an X-chromosome linked hereditary disease that is caused by loss of function mutations in the α-galactosidase A (α-Gal A) gene, resulting in defective glycolipid degradation and subsequent accumulation of globotriaosylceramide (Gb3) in different tissues, including vascular endothelial cells and neurons in the peripheral and central nervous system. We recently reported a differential gene expression profile of α-Gal A(-/0) mouse dorsal root ganglia, an established animal model of Fabry disease, thereby providing new gene targets that might underlie the neuropathic pain related symptoms...
2018: Frontiers in Molecular Neuroscience
Irene Baldi, Mirko Belcastro, Maja Rossi, Armando Rossi, Chiara Minacci, Armando Natale
Rosai-Dorfman (-Destombes) disease (RDDD) is a rare idiopathic disorder of histiocyte proliferation, usually involving lymph node stations. The most common clinical finding is a bilateral cervical lymphadenopathy, fever and weight loss. Arterial or venous structures are notably not involved. We hereby present a case of a 78- year-old male Caucasian, presenting with symptoms of progressive arterial insufficiency and right lower-limb edema, along with a non- pulsatile mass at the middle third of the thigh. Initial diagnostic hypothesis was a superficial femoral artery aneurysm thrombosis with a secondary post-compressive superficial femoral vein thrombosis...
July 13, 2018: Annals of Vascular Surgery
Erik N K Cressman, Chunxiao Guo, Niloofar Karbasian
RATIONALE: Advances in image-guided drug delivery for liver cancer have shown a significant survival benefit. However, incomplete treatment is common and residual disease is often found in explanted liver specimens. In addition, the need to treat a malignancy from multiple mechanisms at the same time for optimal outcomes is becoming more widely appreciated. To address this, we hypothesized that an exothermic chemical reaction could be performed in situ. Such a strategy could in principle combine several angles of attack, including ischemia, hyperthermia, acidic protein denaturation, and metabolic modulation of the local environment...
2018: PloS One
Dariush Kamali, Matthew Thomas, Peter Van Loo, Ian Nichol
BACKGROUND: Transmetatarsal amputation (TMA) has a reputation for failure, centred around wound breakdown. No study has looked at the direct association between the patency of individual crural arteries and the healing of TMA. TMA relies on a posterior skin flap which derives its blood supply from the posterior tibial (PT) artery. We investigated the association between PT patency and achievement of successful TMA. METHODS: A retrospective review of all patients undergoing TMA for complications of peripheral arterial occlusive disease in a regional vascular tertiary referral centre over a 9 year period (2006-2015)...
June 2018: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
Jaroslaw Gorol, Mateusz Tajstra, Bartosz Hudzik, Andrzej Lekston, Mariusz Gąsior
Introduction: Revascularization of patients with heavily calcified coronary arteries can be a challenge for interventional cardiologists. The procedural success rate in these patients can be improved by using rotational atherectomy (RA). Aim: To compare in-hospital outcomes and those at 12-month follow-up between patients who underwent RA as a bailout procedure secondary to failed conventional angioplasty or as an elective procedure. Material and methods: This is a retrospective analysis of 156 consecutive patients hospitalized at a high-volume percutaneous coronary intervention (PCI) center who underwent RA...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Esther D Kim, Hirofumi Tanaka, Shoshana H Ballew, Yingying Sang, Gerardo Heiss, Josef Coresh, Kunihiro Matsushita
RATIONALE & OBJECTIVE: Arterial stiffness is suggested as a mediator of cardiorenal interaction. However, previous studies reported inconsistent associations between chronic kidney disease (CKD) and arterial stiffness and were limited by using either estimated glomerular filtration rate (eGFR) or albumin-creatinine ratio (ACR) and examining arterial stiffness at limited segments. STUDY DESIGN: Cross-sectional. SETTING & PARTICIPANTS: 3,424 Atherosclerosis in Communities (ARIC) Study participants aged 66 to 90 years during 2011 to 2013...
July 11, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Takuya Sakamoto, Wakana Ohashi, Kengo Tomita, Kohshi Hattori, Naoyuki Matsuda, Yuichi Hattori
Cilostazol, a selective inhibitor of phosphodiesterase type III with anti-platelet, anti-mitogenic, and vasodilating properties, is widely used to treat ischemic symptoms of peripheral vascular disease. Ample evidence has suggested that cilostazol also exhibits an anti-inflammatory effect, but its anti-inflammatory mechanism is not fully understood. Here, we showed that cilostazol specifically inhibited expression of cytokines, which are induced by nuclear factor-κB (NF-κB) activation, in RAW264.7 macrophage cells stimulated with different Toll-like receptor (TLR) ligands...
July 10, 2018: International Immunopharmacology
Lisa Riesinger, Michael Saemisch, Markus Nickmann, Heiko Methe
Bone marrow-derived endothelial progenitor cells (EPC) are released into the peripheral blood in situations of vascular repair/angiogenesis. Regulation of vascular repair and angiogenesis by EPC depends not only on the number of circulating EPC but also on their functionality. As endothelial cells can act as antigen-presenting cells in coronary artery disease (CAD), we postulated that EPC can be immune activated here as well. CD34+ -EPC were isolated from peripheral blood of patients with ST-elevation myocardial infarction (STEMI, n = 12), non-STEMI/unstable angina (UA, n = 15), and stable CAD (SA, n = 18)...
July 12, 2018: Heart and Vessels
Dan B Swartzlander, Nicholas E Propson, Ethan R Roy, Takashi Saito, Takaomi Saido, Baiping Wang, Hui Zheng
Nonneuronal cell types in the CNS are increasingly implicated as critical players in brain health and disease. While gene expression profiling of bulk brain tissue is routinely used to examine alterations in the brain under various conditions, it does not capture changes that occur within single cell types or allow interrogation of crosstalk among cell types. To this end, we have developed a concurrent brain cell type acquisition (CoBrA) methodology, enabling the isolation and profiling of microglia, astrocytes, endothelia, and oligodendrocytes from a single adult mouse forebrain...
July 12, 2018: JCI Insight
Oh Chan Kwon, Sang-Won Lee, Yong-Beom Park, Ji Seon Oh, Sang Hoon Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
BACKGROUND: Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to identify the association between vascular and extravascular manifestations of TAK. METHODS: TAK patients from two independent cohorts between January 2012 and October 2017 were included in the study...
July 11, 2018: Arthritis Research & Therapy
Roman Deev, Igor Plaksa, Ilia Bozo, Nina Mzhavanadze, Igor Suchkov, Yuriy Chervyakov, Ilia Staroverov, Roman Kalinin, Artur Isaev
BACKGROUND: The effective treatment of chronic lower limb ischemia is one of the most challenging issues confronting vascular surgeons. Current pharmacological therapies play an auxiliary role and cannot prevent disease progression, and new treatment methods are needed. In 2011, a plasmid VEGF65-gene therapy drug was approved in Russia for the treatment of chronic lower limb ischemia ( identifier: NCT03068585). The objective of this follow-up study was to evaluate the long-term safety and efficacy of gene therapy in patients with limb ischemia of atherosclerotic genesis...
July 1, 2018: Therapeutic Advances in Cardiovascular Disease
Chen-Yu Li, Chee-Jen Chang, Wen-Jung Chung, Cheng-Jui Lin, Shu-Kai Hsueh, Chien-Ho Lee, Chiung-Jen Wu, Tzu-Hsien Tsai, Cheng-I Cheng
Although established guidelines currently recommend the use of the CHA2DS2-VASc score for evaluating embolic risk in AF patients, few studies have evaluated the use of the CHA2DS2-VASc score for predicting cardiovascular outcomes in patients with acute myocardial infarction (AMI). The aim of this study was to determine whether CHA2DS2-VASc score is a predictor of a major adverse cardiocerebral vascular event (MACCE) in AMI patients.This study analyzed data in the Taiwan National Health Insurance Research Database from January 2008 to December 2012...
July 2018: Medicine (Baltimore)
Dinah S Khatir, Michael Pedersen, Per Ivarsen, Kent L Christensen, Bente Jespersen, Niels H Buus
AIM: Progression of chronic kidney disease (CKD) may be accelerated by tissue hypoxia due to impaired blood supply. This could be induced by small artery narrowing resulting in abnormally high intrarenal vascular resistance (RVR). We investigated whether a reduction in RVR achieved by adding vasodilating medical therapy (AVT) is superior to adding nonvasodilating medical therapy (AnonVT) regarding tissue oxygenation and preservation of kidney function. METHODS: Eighty-three grade 3 and 4 CKD patients [estimated glomerular filtration rate (GFR) 34...
July 10, 2018: Journal of Hypertension
Mikko Peltokangas, Velipekka Suominen, Damir Vakhitov, Janne Korhonen, Jarmo Verho, Ville M Mattila, Pekka Romsi, Jukka Lekkala, Antti Vehkaoja, Niku Oksala
We analyze the changes in upper and lower limb pulse transit times (PTT) caused by peripheral artery disease (PAD) and its treatment with percutaneous transluminal angioplasty (PTA) of the superficial femoral artery. PTTs were extracted from the photoplethysmograms (PPG) recorded from an index finger and 2nd toes. PTTs were defined between the R-peaks of the ECG and different reference points of the (PPG): foot and peak points, maxima of 1st and 2nd derivative, and by means of intersecting tangents method. Also the PTTs between the toe and finger pulses were analyzed...
June 28, 2018: IEEE Journal of Biomedical and Health Informatics
Michele Sorelli, Antonia Perrella, Leonardo Bocchi
Vascular ageing is known to be accompanied by arterial stiffening and vascular endothelial dysfunction, and represents an independent factor contributing to the development of cardiovascular disease. The microvascular pulse is affected by the biomechanical alterations of the circulatory system, and has been the focus of studies aiming at the development of non-invasive methods able to extract physiologically relevant features. OBJECTIVE: proposing an approach for the assessment of vascular ageing based on a support vector machine (SVM) learning from features of the pulse contour...
March 9, 2018: IEEE Transactions on Bio-medical Engineering
Julia Merkle, Anton Sabashnikov, Carolyn Weber, Georg Schlachtenberger, Johanna Maier, Anna Spieker, Kaveh Eghbalzadeh, Antje-Christin Deppe, Mohamed Zeriouh, Parwis B Rahmanian, Navid Madershahian, Christian Rustenbach, Yeong-Hoon Choi, Ferdinand Kuhn-Régnier, Oliver Liakopoulos, Thorsten Wahlers
OBJECTIVES: Stanford A acute aortic dissection (AAD) is a life-threatening emergency, typically occurring in older patients and requiring immediate surgical repair. The aim of this study was to evaluate early outcome and short- and long-term survival of patients under and above 65 years of age. METHODS: Two hundred and forty patients with Stanford A AAD underwent aortic surgical repair from January 2006 to April 2015 in our center. After statistical analysis and logistic regression analysis, Kaplan-Meier survival estimation was performed, with up to 9-year follow-up, comprising patients under and above 65 years of age...
July 1, 2018: Perfusion
Didem Mullaaziz, Aslı Kaptanoğlu, Emel Erdal Çalıkoğlu, Hanife Özkayalar
Lipomembranous panniculitis (LP) is a peculiar type of fat necrosis and is reported with various clinical conditions, mostly with peripheral vascular diseases. Here, a case of a 57-year-old woman with a painful erythematous swelling of the right leg in association with venous insufficiency has been reported. Although LP is frequently associated with venous insufficiency, to the best of our knowledge, this is the first report on the beneficial effect of venous insufficiency treatment in LP.
April 23, 2018: Dermatology Reports
Lisa Farndon, John Stephenson, Oliver Binns-Hall, Kayleigh Knight, Sally Fowler-Davis
Background: Peripheral arterial disease affects the lower limb and is associated with diabetes, high cholesterol, smoking and obesity. It increases the risk of cardiovascular morbidity and mortality. It can be symptomatic causing intermittent claudication, but often there are few clinical signs. Podiatrists are able to detect the presence of peripheral arterial disease as part of their lower limb assessment and are well placed to give advice on lifestyle changes to help reduce disease progression...
2018: Journal of Foot and Ankle Research
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