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Dual energy bone marrow

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https://www.readbyqxmd.com/read/29740803/du-zhong-eucommia-ulmoides-oliv-cortex-extract-alleviates-lead-acetate-induced-bone-loss-in-rats
#1
Shanshan Qi, Hongxing Zheng, Chen Chen, Hai Jiang
The purpose of this study was to evaluate the protective effect of Du-Zhong cortex extract (DZCE) on lead acetate-induced bone loss in rats. Forty female Sprague-Dawley rats were randomly divided into four groups: group I (control) was provided with distilled water. Group II (PbAc) received 500 ppm lead acetate in drinking water for 60 days. Group III (PbAc+DZCE) received 500 ppm lead acetate in drinking water, and given intragastric DZCE (100 mg/kg body weight) for 60 days. Group IV (DZCE) was given intragastric DZCE (100 mg/kg body weight) for 60 days...
May 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29704696/evaluation-of-cross-sectional-and-longitudinal-changes-in-volumetric-bone-mineral-density-in-postmenopausal-women-using-single-versus-dual-energy-quantitative-computed-tomography
#2
Jad G Sfeir, Matthew T Drake, Elizabeth J Atkinson, Sara J Achenbach, Jon J Camp, Amanda J Tweed, Louise K McCready, Lifeng Yu, Mark C Adkins, Shreyasee Amin, Sundeep Khosla
Central quantitative computed tomography (QCT) is increasingly used in clinical trials and practice to assess bone mass or strength and to evaluate longitudinal changes in response to drug treatment. Current studies utilize single-energy (SE) QCT scans, which may be confounded both by the amount of bone marrow fat at baseline and changes in marrow fat over time. However, the extent to which marrow fat changes either underestimate volumetric BMD (vBMD) measurements at baseline or under-/overestimate longitudinal changes in vivo in humans remains unclear...
April 25, 2018: Bone
https://www.readbyqxmd.com/read/29679212/diagnostic-performance-of-dual-energy-ct-for-the-detection-of-bone-marrow-oedema-a-systematic-review-and-meta-analysis
#3
Chong Hyun Suh, Seong Jong Yun, Wook Jin, Sun Hwa Lee, So Young Park, Chang-Woo Ryu
OBJECTIVES: The aim of this systematic review and meta-analysis was to assess the sensitivity and specificity of dual-energy CT (DECT) for the detection of bone marrow oedema (BME). METHODS: An electronic search of the PubMed and EMBASE databases was conducted. Bivariate modelling and hierarchical summary receiver-operating characteristic modelling were performed to evaluate the overall diagnostic performance of DECT for BME. Subgroup analysis was performed according to the assessment type (qualitative vs...
April 20, 2018: European Radiology
https://www.readbyqxmd.com/read/29662787/steroid-associated-osteonecrosis-animal-model-in-rats
#4
Li-Zhen Zheng, Jia-Li Wang, Ling Kong, Le Huang, Li Tian, Qian-Qian Pang, Xin-Luan Wang, Ling Qin
Objective: Established preclinical disease models are essential for not only studying aetiology and/or pathophysiology of the relevant diseases but more importantly also for testing prevention and/or treatment concept(s). The present study proposed and established a detailed induction and assessment protocol for a unique and cost-effective preclinical steroid-associated osteonecrosis (SAON) in rats with pulsed injections of lipopolysaccharide (LPS) and methylprednisolone (MPS). Methods: Sixteen 24-week-old male Sprague-Dawley rats were used to induce SAON by one intravenous injection of LPS (0...
April 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29528816/dual-energy-ct-for-abdominal-and-pelvic-trauma
#5
Jeremy R Wortman, Jennifer W Uyeda, Urvi P Fulwadhva, Aaron D Sodickson
Computed tomography (CT) is key to the assessment of hemodynamically stable patients with blunt or penetrating trauma to the abdomen and pelvis. Dual-energy (DE) CT is a technology that allows acquisition of data at both high and low kilovolt peaks, allowing materials that have different x-ray absorption behaviors as a function of kilovolt peak (such as iodine) to be differentiated and quantified. DE CT has a variety of postprocessing applications that may be helpful in abdominal and pelvic trauma, including iodine-selective imaging, virtual monenergetic imaging, and virtual noncalcium imaging...
March 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29492589/-foot-and-ankle-tumours-part-ii-malignant-bone-tumours-and-soft-tissue-tumours-of-the-foot-with-differential-diagnostic-hints
#6
REVIEW
T Grieser
CLINICAL ISSUE: Both benign and malignant tumours are encountered in the foot and ankle. Due to their rarity, however, diagnosis is often uncertain. Usual criteria such as tumour size, invasiveness or pain fail to differentiate benign from malignant neoplasias. STANDARD RADIOLOGICAL METHODS: Plain radiography and-due to the complex foot anatomy-CT are important in the diagnostic evaluation of primary bone tumours. In the case of soft tissue tumours, ultrasonography is used to identify ganglion cysts...
May 2018: Der Radiologe
https://www.readbyqxmd.com/read/29489596/effect-of-leptin-on-marrow-adiposity-in-ovariectomized-rabbits-assessed-by-proton-magnetic-resonance-spectroscopy
#7
Shaojun Li, Hongning Jiang, Bo Wang, Mingjun Gu, Ning Zhang, Wenwen Liang, Yu Wang
OBJECTIVE: Leptin acts to influence bone metabolism through indirect hypothalamic relay and direct peripheral pathways. Leptin enhances the differentiation of mesenchymal stem cells to the osteoblast rather than the adipocyte lineage, but the in vivo impacts of leptin on ovariectomy (OVX)-induced marrow adiposity are poorly understood. In this work, we aimed to address this question. METHODS: Forty-five female New Zealand rabbits were divided into sham + vehicle, OVX + vehicle, and OVX + leptin for 5 months...
February 27, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29489595/the-ability-of-dual-energy-computed-tomography-to-distinguish-normal-bone-marrow-from-metastases-using-bone-marrow-color-maps
#8
Ghada Issa, Derik Davis, Michael E Mulligan
OBJECTIVE: The objective of this study was to determine if dual-energy computed-tomography bone marrow color maps can improve sensitivity, specificity, accuracy, and confidence of detection of bone metastases. METHODS: Institutional review board approved this retrospective review of a consecutive series of cancer patients. Two radiologists first evaluated the fused 120 kV computed tomography images and recorded a number of suspicious lesions, confidence level, and Hounsfield units for each lesion...
February 27, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29489560/dual-energy-computed-tomography-based-display-of-bone-marrow-edema-in-incidental-vertebral-compression-fractures-diagnostic-accuracy-and-characterization-in-oncological-patients-undergoing-routine-staging-computed-tomography
#9
Claudia Frellesen, Mehrnoush Azadegan, Simon S Martin, Katharina Otani, Tommaso DʼAngelo, Christian Booz, Katrin Eichler, Bita Panahi, Moritz Kaup, Ralf W Bauer, Thomas J Vogl, Julian L Wichmann
PURPOSE: The aim of this study was to evaluate the diagnostic performance of virtual noncalcium (VNCa) dual-energy computed tomography (DECT) reconstructions enabling visualization of bone marrow edema for characterization of incidental thoracolumbar compression fractures in routine thoracoabdominal staging computed tomography (CT). MATERIALS AND METHODS: We retrospectively analyzed 51 oncological patients without suspected fracture or indicative complaints presenting at least 1 thoracolumbar compression fracture on routine thoracoabdominal staging DECT who had been examined between October 2015 and June 2017 using third-generation dual-source CT, had a previous CT within 3 months before, and also had undergone additional magnetic resonance imaging within 14 days, which served as the standard of reference...
February 27, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29470155/clinical-utility-of-dual-energy-ct-analysis-of-bone-marrow-edema-in-acute-wrist-fractures
#10
Ismail T Ali, William D Wong, Teresa Liang, Faisal Khosa, Memoona Mian, Sabeena Jalal, Savvas Nicolaou
OBJECTIVE: The purpose of this study is to determine the utility of dual-energy CT (DECT) for assessing carpal fractures and to obtain an attenuation value cutoff (in Hounsfield units) to identify bone marrow edema due to an acute carpal fracture. MATERIALS AND METHODS: In this retrospective study, 24 patients who presented with wrist fractures from September 3, 2014, through March 9, 2015, underwent imaging with DECT (80 and 140 kVp). Using the three-material decomposition algorithm specific for virtual noncalcium to construct images, two radiologists identified carpal fractures and associated bone marrow edema...
April 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29362142/diagnostic-accuracy-of-dual-energy-computed-tomography-in-bone-marrow-edema-with-vertebral-compression-fractures-a-meta-analysis
#11
Pei Yang, Guangyao Wu, Xiaodan Chang
PURPOSE: This meta-analysis aimed to evaluate the diagnostic performance of dual-energy computed tomography (DECT) for the bone marrow edema (BME) in patients with vertebral compression fractures. METHODS: The PubMed, EMBASE, and the Cochrane Library database were searched up to July 2017 for relevant original studies. Data were extracted to calculate the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive and negative likelihood ratios (PLR and NLR), and areas under summary receiver operating characteristic (SROC) curves for analysis...
February 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29360704/association-between-insulin-resistance-and-the-magnetic-resonance-spectroscopy-determined-marrow-fat-fraction-in-nondiabetic-postmenopausal-women
#12
Guanwu Li, Zheng Xu, Haiyang Lin, Yilei Chen, Xuefeng Li, Shixin Chang
OBJECTIVE: The clinical consequences of insulin resistance and hyperinsulinemia on marrow lipid remain elusive. We aimed to explore the effects of anthropometric and biochemical measures, that is, estimates of insulin resistance, on marrow lipid accumulation in nondiabetic postmenopausal women using magnetic resonance (MR) spectroscopy. METHODS: The study participants were 91 nondiabetic postmenopausal women. Marrow fat fraction (FF) at the L3 vertebral body by single-voxel MR spectroscopy and bone mineral density (BMD) by dual-energy x-ray absorptiometry were measured...
January 22, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29331301/marrow-adipose-tissue-imaging-in-humans
#13
Vibha Singhal, Miriam A Bredella
Bone strength is affected not only by bone mineral density (BMD) and bone microarchitecture but also its microenvironment. Recent studies have focused on the role of marrow adipose tissue (MAT) in the pathogenesis of bone loss. Osteoblasts and adipocytes arise from a common mesenchymal stem cell within bone marrow and many osteoporotic states, including aging, medication use, immobility, over - and undernutrition are associated with increased marrow adiposity. Advancements in imaging technology allow the non-invasive quantification of MAT...
January 10, 2018: Bone
https://www.readbyqxmd.com/read/29261468/can-dual-energy-ct-challenge-mr-imaging-in-the-diagnosis-of-focal-infiltrative-bone-marrow-lesions
#14
William E Palmer, F Joseph Simeone
No abstract text is available yet for this article.
January 2018: Radiology
https://www.readbyqxmd.com/read/29240803/bone-edema-on-magnetic-resonance-imaging-is-highly-associated-with-low-bone-mineral-density-in-patients-with-ankylosing-spondylitis
#15
Danmin Wang, Zhiduo Hou, Yao Gong, Subiao Chen, Ling Lin, Zhengyu Xiao
OBJECTIVE: This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). METHODS: The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29138859/17%C3%AE-estradiol-attenuates-ovariectomy%C3%A2-induced-bone-deterioration-through-the-suppression-of-the-epha2-ephrina2-signaling-pathway
#16
Lianyong Liu, Lin Zhou, Xiaorong Yang, Qi Liu, Ling Yang, Chao Zheng, Yongling Zhao, Zhenlin Zhang, Xiaohong Luo
The present study aimed to investigate whether 17β‑estradiol (E2) exerts protective effects on bone deterioration induced by ovariectomy (OVX) through the ephA2/ephrinA2 signaling pathway in rats. Female rats were subjected to OVX, sham surgeryor OVX+E2 treatment. Levels of biomarkers were measured in serum and urine. Hematoxylin and eosin staining was performed on paraffin‑embedded bone sections. Expression of genes and proteins was analyzed by reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively...
January 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28987656/meta-analysis-of-dual-energy-computed-tomography-virtual-non-calcium-imaging-to-detect-bone-marrow-edema
#17
Mou Li, Yali Qu, Bin Song
OBJECTIVE: This meta-analysis aimed to evaluate the accuracy of dual-energy CT (DECT) virtual non-calcium (VNC) imaging for the detection of bone marrow edema (BME). METHODS: A systematic literature search up to March 2017 was performed to find relevant original studies. Two reviewers independently selected studies, assessed literature quality, and extracted data. Pooled sensitivity, specificity, area under receiver operating characteristic (AUROC) curve, and other measures of DECT accuracy for detecting BME were calculated using random effects models...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28977604/metformin-affects-cortical-bone-mass-and-marrow-adiposity-in-diet-induced-obesity-in-male-mice
#18
Sheila Bornstein, Michele Moschetta, Yawara Kawano, Antonio Sacco, Daisy Huynh, Daniel Brooks, Salomon Manier, Heather Fairfield, Carolyne Falank, Aldo M Roccaro, Kenichi Nagano, Roland Baron, Mary Bouxein, Calvin Vary, Irene M Ghobrial, Clifford J Rosen, Michaela R Reagan
Obesity during maturation can affect the growing skeleton directly and indirectly, although these effects and the mechanisms behind them are not fully understood. Our objective was to determine how a high-fat diet with or without metformin treatment affects skeletal development. We also sought to characterize changes that occur in white adipose tissue, circulating metabolites, lipids, and gut microbiota. A diet-induced obesity C57BL/6J mouse model was used to test the effects of obesity and metformin on bone using bone histomorphometry and microcomputed tomography...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28948859/whole-body-distribution-of-leukemia-and-functional-total-marrow-irradiation-based-on-flt-pet-and-dual-energy-ct
#19
Taiki Magome, Jerry Froelich, Shernan G Holtan, Yutaka Takahashi, Michael R Verneris, Keenan Brown, Kathryn Dusenbery, Jeffrey Wong, Susanta K Hui
This report describes a multimodal whole-body 3'-deoxy-3'[(18)F]-fluorothymidine positron emission tomography (FLT-PET) and dual-energy computed tomography (DECT) method to identify leukemia distribution within the bone marrow environment (BME) and to develop disease- and/or BME-specific radiation strategies. A control participant and a newly diagnosed patient with acute myeloid leukemia prior to induction chemotherapy were scanned with FLT-PET and DECT. The red marrow (RM) and yellow marrow (YM) of the BME were segmented from DECT using a basis material decomposition method...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28900555/the-utility-of-dual-energy-computed-tomography-in-musculoskeletal-imaging
#20
REVIEW
Sachin Khanduri, Aakshit Goyal, Bhumika Singh, Mriganki Chaudhary, Tushar Sabharwal, Shreshtha Jain, Hritik Sharma
The objective of this article is to review the mechanisms, advantages and disadvantages of dual energy computed tomography (DECT) over conventional tomography (CT) in musculoskeletal imaging as DECT provides additional information about tissue composition and artifact reduction. This provides clinical utility in detection of urate crystals, bone marrow edema, reduction of beam hardening metallic artifact, and ligament and tendon analysis.
2017: Journal of Clinical Imaging Science
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