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https://www.readbyqxmd.com/read/27910506/assessment-of-the-measurement-performance-of-the-in-vessel-system-of-gap-6-of-the-iter-plasma-position-reflectometer-using-a-finite-difference-time-domain-maxwell-full-wave-code
#1
F da Silva, S Heuraux, E Ricardo, P Quental, J Ferreira
We conducted a first assessment of the measurement performance of the in-vessel components at gap 6 of the ITER plasma position reflectometry with the aid of a synthetic Ordinary Mode (O-mode) broadband frequency-modulated continuous-wave reflectometer implemented with REFMUL, a 2D finite-difference time-domain full-wave Maxwell code. These simulations take into account the system location within the vacuum vessel as well as its access to the plasma. The plasma case considered is a baseline scenario from Fusion for Energy...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910095/a-comparison-of-methods-for-estimating-the-incidence-of-human-immunodeficiency-virus-infection-in-repeat-blood-donors
#2
Donald J Brambilla, Michael P Busch, Roger Y Dodd, Simone A Glynn, Steven H Kleinman
BACKGROUND: The incidence of human immunodeficiency virus (HIV) in repeat blood donors has been estimated using seven methods. Although incidence is always calculated as cases per person-time, approaches to selecting cases and calculating person-time vary. Incidence estimates have not been compared among methods. STUDY DESIGN AND METHODS: The seven methods were compared in a simulation study. Because three methods used information from donations made before an estimation interval, 8 years of donation and infection history were simulated, and Years 7 and 8 were treated as the estimation interval for all methods...
December 1, 2016: Transfusion
https://www.readbyqxmd.com/read/27909943/simulating-different-dosing-scenarios-for-a-child-appropriate-valproate-er-formulation-in-a-new-pediatric-two-stage-dissolution-model
#3
Frank Karkossa, Antonia Krueger, Jana Urbaniak, Sandra Klein
Predictive in vitro test methods addressing the parameters relevant to drug release in the pediatric gastrointestinal tract could be an appropriate means for reducing the number of in vivo studies in children. However, dissolution models addressing the particular features of pediatric gastrointestinal physiology and typical pediatric dosing scenarios have not yet been described. The objective of the present study was to combine the knowledge on common vehicle types and properties and current information on pediatric gastrointestinal physiology to design a dissolution model that enables a biorelevant simulation of the gastrointestinal conditions in young children...
December 1, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27907192/adaptive-test-schemes-for-control-of-paratuberculosis-in-dairy-cows
#4
Carsten Kirkeby, Kaare Græsbøll, Søren Saxmose Nielsen, Lasse Engbo Christiansen, Nils Toft, Tariq Halasa
Paratuberculosis is a chronic infection that in dairy cattle causes reduced milk yield, weight loss, and ultimately fatal diarrhea. Subclinical animals can excrete bacteria (Mycobacterium avium ssp. paratuberculosis, MAP) in feces and infect other animals. Farmers identify the infectious animals through a variety of test-strategies, but are challenged by the lack of perfect tests. Frequent testing increases the sensitivity but the costs of testing are a cause of concern for farmers. Here, we used a herd simulation model using milk ELISA tests to evaluate the epidemiological and economic consequences of continuously adapting the sampling interval in response to the estimated true prevalence in the herd...
2016: PloS One
https://www.readbyqxmd.com/read/27907024/utility-evaluation-based-on-one-to-n-mapping-in-the-prisoner-s-dilemma-game-for-interdependent-networks
#5
Juan Wang, Wenwen Lu, Lina Liu, Li Li, Chengyi Xia
In the field of evolutionary game theory, network reciprocity has become an important means to promote the level of promotion within the population system. Recently, the interdependency provides a novel perspective to understand the widespread cooperation behavior in many real-world systems. In previous works, interdependency is often built from the direct or indirect connections between two networks through the one-to-one mapping mode. However, under many realistic scenarios, players may need much more information from many neighboring agents so as to make a more rational decision...
2016: PloS One
https://www.readbyqxmd.com/read/27906604/statistical-considerations-regarding-to-correlated-lots-in-analytical-biosimilar-equivalence-test
#6
Meiyu Shen, Tianhua Wang, Yi Tsong
In the evaluation of the analytical similarity data, an equivalence testing approach for most critical and quantitative quality attributes, that are assigned to Tier 1 in their proposed three-tier approach, was proposed (Tsong, Dong, and Shen, 2016). Food and Drug Administration (FDA) has recommended the proposed equivalence testing approach to sponsors through meeting comments for Pre-Investigational New Drug Applications (PINDs) and Investigational New Drug Applications (INDs) since 2014. FDA has received some feedbacks on statistical issues of potentially correlated reference lot values subjected to the equivalence testing since independent and identical observations (lot values) from the proposed biosimilar product and the reference product are assumed...
December 1, 2016: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/27905942/a-novel-method-for-estimating-distributions-of-body-mass-index
#7
Marie Ng, Patrick Liu, Blake Thomson, Christopher J L Murray
BACKGROUND: Understanding trends in the distribution of body mass index (BMI) is a critical aspect of monitoring the global overweight and obesity epidemic. Conventional population health metrics often only focus on estimating and reporting the mean BMI and the prevalence of overweight and obesity, which do not fully characterize the distribution of BMI. In this study, we propose a novel method which allows for the estimation of the entire distribution. METHODS: The proposed method utilizes the optimization algorithm, L-BFGS-B, to derive the distribution of BMI from three commonly available population health statistics: mean BMI, prevalence of overweight, and prevalence of obesity...
March 12, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905066/a-multiscale-approach-to-the-migration-of-cancer-stem-cells-mathematical-modelling-and-simulations
#8
Nikolaos Sfakianakis, Niklas Kolbe, Nadja Hellmann, Mária Lukáčová-Medvid'ová
We propose a multiscale model for the invasion of the extracellular matrix by two types of cancer cells, the differentiated cancer cells and the cancer stem cells. We investigate the epithelial mesenchymal-like transition between them being driven primarily by the epidermal growth factors. We moreover take into account the transdifferentiation program of the cancer stem cells towards the cancer-associated fibroblast cells as well as the fibroblast-driven remodelling of the extracellular matrix. The proposed haptotaxis model combines the macroscopic phenomenon of the invasion of the extracellular matrix by both types of cancer cells with the microscopic dynamics of the epidermal growth factors...
November 30, 2016: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/27903211/participant-perceptions-of-a-rapid-response-team-training-course
#9
Richard Chalwin, Sam Radford, Alex Psirides, Russell Laver, Petra Bierer, Sumeet Rai, Cameron Knott, John Dyett, Daryl Jones
BACKGROUND: Rapid response team (RRT) responders would benefit from training, to ensure competent and efficient management of the deteriorating patient. DESIGN, SETTING AND PARTICIPANTS: We obtained delegate feedback on a pilot training course for RRTs, commissioned by the Australian and New Zealand Intensive Care Society (ANZICS), at the second ANZICS: The Deteriorating Patient Conference. METHODS: We surveyed participants on their perceptions of the course overall, and their perceptions of sessions containing presentations and videotaped and live demonstrations of simulated scenarios of patients whose conditions were deteriorating...
December 2016: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/27902924/simple-mechanisms-of-early-life-simulation-model-on-the-origin-of-semi-cells
#10
Adrian Klein, Martin Bock, Wolfgang Alt
The development of first cellular structures played an important role in the early evolution of life. Early evolution of life probably took place on a molecular level in a reactive environment. The iron-sulfur theory postulates the formation of cell-like structures on catalytic surfaces. Experiments show that H2S together with FeS and other metallic centers drive auto-catalytic surface reactions, in which organic molecules such as pyruvic and amino acids occur. It is questionable which mechanisms are needed to form cell-like structures under these conditions...
November 27, 2016: Bio Systems
https://www.readbyqxmd.com/read/27902693/the-long-term-benefits-of-increased-aspirin-use-by-at-risk-americans-aged-50-and-older
#11
David B Agus, Étienne Gaudette, Dana P Goldman, Andrew Messali
BACKGROUND: The usefulness of aspirin to defend against cardiovascular disease in both primary and secondary settings is well recognized by the medical profession. Multiple studies also have found that daily aspirin significantly reduces cancer incidence and mortality. Despite these proven health benefits, aspirin use remains low among populations targeted by cardiovascular prevention guidelines. This article seeks to determine the long-term economic and population-health impact of broader use of aspirin by older Americans at higher risk for cardiovascular disease...
2016: PloS One
https://www.readbyqxmd.com/read/27902533/using-simulation-in-global-health-considerations-for-design-and-implementation
#12
Michael B Pitt, Walter J Eppich, Margaret L Shane, Sabrina M Butteris
Providers and educators increasingly participate in global health work during their careers. Simulation can play an important role in both preparing learners for work in resource-limited settings and training providers in these countries. However, little guidance exists for educators interested in creating and implementing scenarios for these settings. We discuss several key considerations unique to global health simulation ranging from addressing common cultural differences surrounding healthcare and varied regional approaches to disease identification and management to understanding precisely what resources exist in the setting and what strategies can be used to provide care when the expected resources are not available...
November 29, 2016: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/27902466/long-non-coding-rna-urothelial-carcinoma-associated-1-uca1-mediates-radiation-response-in-prostate-cancer
#13
Alireza Fotouhi Ghiam, Samira Taeb, Xiaoyong Huang, Vincent Huang, Jessica Ray, Seville Scarcello, Christianne Hoey, Sahar Jahangiri, Emmanouil Fokas, Andrew Loblaw, Robert G Bristow, Danny Vesprini, Paul Boutros, Stanley K Liu
Radioresistance remains a significant obstacle in the treatment of Prostate Cancer (PCa). To simulate the clinical scenario of irradiation resistance (IRR), we created DU145-IRR PCa cell lines by treatment with 2 Gy daily IR for 59 fractions. DU145-IRR cells acquired an aggressive phenotype as evidenced by increased clonogenic survival, tumorigenic potential and invasiveness. We performed transcriptome profiling to discover dysregulated genes in DU145-IRR cells and identified the long non-coding RNA (lncRNA), Urothelial carcinoma-associated 1 (UCA1)...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27900789/a-general-approach-to-testing-for-pleiotropy-with-rare-and-common-variants
#14
Sharon M Lutz, Tasha E Fingerlin, John E Hokanson, Christoph Lange
Through genome-wide association studies, numerous genes have been shown to be associated with multiple phenotypes. To determine the overlap of genetic susceptibility of correlated phenotypes, one can apply multivariate regression or dimension reduction techniques, such as principal components analysis, and test for the association with the principal components of the phenotypes rather than the individual phenotypes. However, as these approaches test whether there is a genetic effect for at least one of the phenotypes, a significant test result does not necessarily imply pleiotropy...
November 30, 2016: Genetic Epidemiology
https://www.readbyqxmd.com/read/27900475/microclimatic-effects-of-planted-hydroponic-structures-in-urban-environment-measurements-and-simulations
#15
N Katsoulas, D Antoniadis, I L Tsirogiannis, E Labraki, T Bartzanas, C Kittas
The objectives of this effort was to study the effect of vertical (green wall) and horizontal (pergola) green structures on the microclimate conditions of the building surroundings and estimate the thermal perception and heat stress conditions near the two structures. The experimental data were used to validate the results simulated by the recent version (V4.0 preview III) of ENVI-met software which was used to simulate the effect of different design parameters of a pergola and a green façade on microclimate and heat stress conditions...
November 29, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27899826/an-elective-course-in-cardiovascular-electrophysiology-for-pharmacy-learners
#16
Diptiman D Bose
Objective. To implement an integrated, comprehensive, and learner-centered elective course focused at exposing learners to the interpretation of electrocardiograms and highlighting the mechanisms underlining the abnormal electrophysiological events. Design. Learners were presented with foundational information on the mechanisms underlying electrophysiological changes associated with the development of arrhythmias. They then discussed the interpretation of electrocardiogram (ECG) recordings and diagnosis of cardiovascular events...
October 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27898927/effect-of-feeding-strategy-on-environmental-impacts-of-pig-fattening-in-different-contexts-of-production-evaluation-through-life-cycle-assessment
#17
A N T R Monteiro, F Garcia-Launay, L Brossard, A Wilfart, J-Y Dourmad
Life cycle assessment (LCA) has been used in many studies to evaluate the effect of feeding strategy on the environmental impact of pig production. However, because most studies have been conducted in European conditions, the question of possible interactions with the context of production is still under debate. The objective of this study was to evaluate these effects in 2 contrasted geographic contexts of production, South America (Brazil) and Europe (France). The LCA considered the process of pig fattening, including production and transport of feed ingredients and feed, raising of fattening pigs, and manure storage, transport, and spreading...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898005/validation-and-parameter-sensitivity-tests-for-reconstructing-swell-field-based-on-an-ensemble-kalman-filter
#18
Xuan Wang, Pierre Tandeo, Ronan Fablet, Romain Husson, Lei Guan, Ge Chen
The swell propagation model built on geometric optics is known to work well when simulating radiated swells from a far located storm. Based on this simple approximation, satellites have acquired plenty of large samples on basin-traversing swells induced by fierce storms situated in mid-latitudes. How to routinely reconstruct swell fields with these irregularly sampled observations from space via known swell propagation principle requires more examination. In this study, we apply 3-h interval pseudo SAR observations in the ensemble Kalman filter (EnKF) to reconstruct a swell field in ocean basin, and compare it with buoy swell partitions and polynomial regression results...
November 25, 2016: Sensors
https://www.readbyqxmd.com/read/27897988/reciprocally-benefited-secure-transmission-for-spectrum-sensing-based-cognitive-radio-sensor-networks
#19
Dawei Wang, Pinyi Ren, Qinghe Du, Li Sun, Yichen Wang
The rapid proliferation of independently-designed and -deployed wireless sensor networks extremely crowds the wireless spectrum and promotes the emergence of cognitive radio sensor networks (CRSN). In CRSN, the sensor node (SN) can make full use of the unutilized licensed spectrum, and the spectrum efficiency is greatly improved. However, inevitable spectrum sensing errors will adversely interfere with the primary transmission, which may result in primary transmission outage. To compensate the adverse effect of spectrum sensing errors, we propose a reciprocally-benefited secure transmission strategy, in which SN's interference to the eavesdropper is employed to protect the primary confidential messages while the CRSN is also rewarded with a loose spectrum sensing error probability constraint...
November 25, 2016: Sensors
https://www.readbyqxmd.com/read/27896984/methods-for-clustering-time-series-data-acquired-from-mobile-health-apps
#20
Nicole Tignor, Pei Wang, Nicholas Genes, Linda Rogers, Steven G Hershman, Erick R Scott, Micol Zweig, Yu-Feng Yvonne Chan, Eric E Schadt
In our recent Asthma Mobile Health Study (AMHS), thousands of asthma patients across the country contributed medical data through the iPhone Asthma Health App on a daily basis for an extended period of time. The collected data included daily self-reported asthma symptoms, symptom triggers, and real time geographic location information. The AMHS is just one of many studies occurring in the context of now many thousands of mobile health apps aimed at improving wellness and better managing chronic disease conditions, leveraging the passive and active collection of data from mobile, handheld smart devices...
2016: Pacific Symposium on Biocomputing
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