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https://www.readbyqxmd.com/read/29169229/novel-vertebral-indices-in-normal-and-spinal-disorder-dogs-using-computed-tomography
#1
Jongsu Lim, Youngmin Yoon, Taesung Hwang, Hee Chun Lee
This study was carried out to derive reference value of normal spine indices, and to evaluate the feasibility of the indices for computed tomography (CT). CT images and magnetic resonance imaging were acquired from clinically normal 12 beagle dogs for normal group and 50 dogs with 56 spinal disorders for patient group. Image acquisition regions were cervical spine (C2 to T1), thoracic spine (T1-T13) and lumbar spine (L1-L7). The measured indices are as follows; the ratio of width to height of spinal cord include dura matter (CR) and vertebral foramen (FR), and the ratio of cross sectional area of spinal cord to vertebral foramen (CFAR)...
November 23, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29169117/3d-correction-over-2years-with-anterior-vertebral-body-growth-modulation-a-finite-element-analysis-of-screw-positioning-cable-tensioning-and-postoperative-functional-activities
#2
Nikita Cobetto, Stefan Parent, Carl-Eric Aubin
BACKGROUND: Anterior vertebral body growth modulation is a fusionless instrumentation to correct scoliosis using growth modulation. The objective was to biomechanically assess effects of cable tensioning, screw positioning and post-operative position on tridimensional correction. METHODS: The design of experiments included two variables: cable tensioning (150/200N) and screw positioning (lateral/anterior/triangulated), computationally tested on 10 scoliotic cases using a personalized finite element model to simulate spinal instrumentation, and 2years growth modulation with the device...
November 16, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29169050/utility-of-post-mortem-computed-tomography-in-clivus-fracture-diagnosis-case-illustration-and-literature-review
#3
S Zerbo, A Di Piazza, G Lo Re, G L Aronica, S Salerno, R Lagalla
Clivus fractures are usually associated with head blunt trauma due to traffic accident and falls. A 23 - year-old man died immediately after a smash-up while he was stopping on his motorcycle. Post-mortem Computed tomography (PMCT), performed before autopsy, revealed a complex basilar skull base fractures associated with brainstem and cranio-vertebral junction injuries, improving the diagnostic performance of conventional autopsy. Imaging data were re-assessable and PMCT offers the possibility to perform multiplanar and volume rendered reconstructions, increasing forensic medicine knowledge related to traumatic injuries...
November 16, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29168789/lead-emissions-and-population-vulnerability-in-the-detroit-michigan-usa-metropolitan-area-2006-2013-a-spatial-and-temporal-analysis
#4
Heather Moody, Sue C Grady
Objective: The purpose of this research is to geographically model airborne lead emission concentrations and total lead deposition in the Detroit Metropolitan Area (DMA) from 2006 to 2013. Further, this study characterizes the racial and socioeconomic composition of recipient neighborhoods and estimates the potential for IQ (Intelligence Quotient) loss of children residing there. Methods: Lead emissions were modeled from emitting facilities in the DMA using AERMOD (American Meteorological Society/Environmental Protection Agency Regulatory Model)...
November 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29168762/dual-roles-of-fer-kinase-are-required-for-proper-hematopoiesis-and-vascular-endothelium-organization-during-zebrafish-development
#5
Emily M Dunn, Elizabeth J Billquist, Amy L VanderStoep, Phillip G Bax, Laura M Westrate, Lisa K McLellan, Shelby C Peterson, Jeffrey P MacKeigan, Aaron P Putzke
Fer kinase, a protein involved in the regulation of cell-cell adhesion and proliferation, has been shown to be required during invertebrate development and has been implicated in leukemia, gastric cancer, and liver cancer. However, in vivo roles for Fer during vertebrate development have remained elusive. In this study, we bridge the gap between the invertebrate and vertebrate realms by showing that Fer kinase is required during zebrafish embryogenesis for normal hematopoiesis and vascular organization with distinct kinase dependent and independent functions...
November 23, 2017: Biology
https://www.readbyqxmd.com/read/29168619/gut-microbes-limit-growth-in-house-sparrows-nestlings-passer-domesticus-but-not-through-limitations-in-digestive-capacity
#6
Kevin D Kohl, Antonio Brun, Seth R Bordenstein, Enrique Caviedes-Vidal, William H Karasov
Recent research often lauds the services and beneficial effects of host-associated microbes on animals. However, hosting these microbes may come at a cost. For example, germ-free and antibiotic-treated birds generally grow faster than their conventional counterparts. In the wild, juvenile body size is correlated with survival, so hosting a microbiota may incur a fitness cost. Avian altricial nestlings represent an interesting study system in which to investigate these interactions, given that they exhibit the fastest growth rates among vertebrates, and growth is limited by their digestive capacity...
November 23, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/29168617/carnivore-stable-carbon-isotope-niches-reflect-predator-prey-size-relationships-in-african-savannas
#7
Jacqueline Codron, Nico L Avenant, Corli Wigley-Coetsee, Daryl Codron
Predator-prey size relationships are among the most important patterns underlying the structure and function of ecological communities. Indeed, these relationships have already been shown to be important for understanding patterns of macroevolution and differential extinction in the terrestrial vertebrate fossil record. Stable isotope analysis (SIA) is a powerful remote approach to examining animal diets and palaeodiets. The approach is based on the principle that isotope compositions of consumer tissues reflect those of their prey...
November 23, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/29168448/a-competitive-enzyme-linked-immunosorbent-assay-for-rapid-detection-of-antibodies-against-trichinella-spiralis-and-t-britovi-one-test-for-humans-and-swine
#8
M Gnjatovic, A Gruden-Movsesijan, N Miladinovic-Tasic, N Ilic, S Vasilev, J Cvetkovic, Lj Sofronic-Milosavljevic
Infection with parasites from the Trichinella genus occurs in many vertebrates but disease only occurs in humans (trichinellosis). Humans are infected after the consumption of raw or undercooked meat from infected wild or domestic animals (usually swine or horses). Using the monoclonal antibody (mAb) 7C2C5, specific for an epitope unique to the muscle larvae of the genus Trichinella, we have developed a competitive enzyme-linked immunosorbent assay (c-ELISA) that enables the rapid detection of Trichinella-specific antibodies in sera originating from two different host species (human, swine) infected with either Trichinella spiralis or Trichinella britovi...
November 23, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/29168009/dietary-lipophilic-iron-accelerates-regional-brain-iron-load-in-c57bl6-mice
#9
Douglas G Peters, Carson J Purnell, Michael P Haaf, Qing X Yang, James R Connor, Mark D Meadowcroft
Impaired brain iron homeostatic mechanisms, independent of pathological hallmarks, are harmful to the brain because excess free iron can cause DNA, protein, and lipid damage via oxidative stress. The goal of this study was to evaluate the longitudinal effect of chronic iron overload and deficiency in the vertebrate brain. Ten-week-old C57BL6 male mice were randomly assigned to one of four unique dietary regiments for 1 year: iron-deficient, normal iron, and two different concentrations of lipophilic iron diet containing 3,5,5-trimethylhexanoyl ferrocene (TMHF)...
November 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29167971/abaloparatide-sc-improves-trabecular-microarchitecture-as-assessed-by-trabecular-bone-score-tbs-a-24-week-randomized-clinical-trial
#10
J P Bilezikian, G Hattersley, L A Fitzpatrick, A G Harris, E Shevroja, K Banks, B Z Leder, J R Zanchetta, D Hans
In a phase 2 trial of 222 postmenopausal women with osteoporosis aged 55 to 85 years randomized to one of three different doses of abaloparatide-SC, subcutaneous teriparatide, or placebo for 24 weeks, abaloparatide-SC resulted in improvements in skeletal microarchitecture as measured by the trabecular bone score. INTRODUCTION: Subcutaneous abaloparatide (abaloparatide-SC) increases total hip and lumbar spine bone mineral density and reduces vertebral and non-vertebral fractures. In this study, we analyzed the extent to which abaloparatide-SC improves skeletal microarchitecture, assessed indirectly by trabecular bone score (TBS)...
November 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29167970/independent-association-of-bone-mineral-density-and-trabecular-bone-score-to-vertebral-fracture-in-male-subjects-with-chronic-obstructive-pulmonary-disease
#11
R Watanabe, N Tai, J Hirano, Y Ban, D Inoue, R Okazaki
Osteoporosis is a major comorbidity of chronic obstructive pulmonary disease (COPD), but the mechanism of bone fragility is unknown. We demonstrated that trabecular bone score, a parameter of bone quality, was associated with systemic inflammation and was a significant determinant of vertebral fracture independent of bone mineral density. INTRODUCTION: COPD is a major cause of secondary osteoporosis. However, the mechanism of bone fragility is unclear. We previously reported that vertebral fracture was highly prevalent in male COPD patients...
November 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29167930/planarian-cholinesterase-molecular-and-functional-characterization-of-an-evolutionarily-ancient-enzyme-to-study-organophosphorus-pesticide-toxicity
#12
Danielle Hagstrom, Siqi Zhang, Alicia Ho, Eileen S Tsai, Zoran Radić, Aryo Jahromi, Kelson J Kaj, Yingtian He, Palmer Taylor, Eva-Maria S Collins
The asexual freshwater planarian Dugesia japonica has emerged as a medium-throughput alternative animal model for neurotoxicology. We have previously shown that D. japonica are sensitive to organophosphorus pesticides (OPs) and characterized the in vitro inhibition profile of planarian cholinesterase (DjChE) activity using irreversible and reversible inhibitors. We found that DjChE has intermediate features of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Here, we identify two candidate genes (Djche1 and Djche2) responsible for DjChE activity...
November 22, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29167503/structural-analyses-of-adenylate-kinases-from-antarctic-and-tropical-fishes-for-understanding-cold-adaptation-of-enzymes
#13
Sojin Moon, Junhyung Kim, Euiyoung Bae
Psychrophiles are extremophilic organisms capable of thriving in cold environments. Proteins from these cold-adapted organisms can remain physiologically functional at low temperatures, but are structurally unstable even at moderate temperatures. Here, we report the crystal structure of adenylate kinase (AK) from the Antarctic fish Notothenia coriiceps, and identify the structural basis of cold adaptation by comparison with homologues from tropical fishes including Danio rerio. The structure of N. coriiceps AK (AKNc) revealed suboptimal hydrophobic packing around three Val residues in its central CORE domain, which are replaced with Ile residues in D...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167383/c-terminal-src-kinase-csk-regulates-the-tricellular-junction-protein-gliotactin-independent-of-src
#14
G D N Gayathri Samarasekera, Vanessa Jane Auld
Tricellular junctions (TCJs) are uniquely placed permeability barriers formed at the corners of polarized epithelia where tight junctions (TJ) in vertebrates or septate junctions (SJ) in invertebrates from three cells converge. Gliotactin is a Drosophila TCJ protein and loss of Gliotactin results in SJ and TCJ breakdown, and permeability barrier loss. When overexpressed, Gliotactin spreads away from the TCJs resulting in disrupted epithelial architecture including over-proliferation, cell delamination and migration...
November 22, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29167368/perception-of-contextual-size-illusions-by-honeybees-in-restricted-and-unrestricted-viewing-conditions
#15
Scarlett R Howard, Aurore Avarguès-Weber, Jair E Garcia, Devi Stuart-Fox, Adrian G Dyer
How different visual systems process images and make perceptual errors can inform us about cognitive and visual processes. One of the strongest geometric errors in perception is a misperception of size depending on the size of surrounding objects, known as the Ebbinghaus or Titchener illusion. The ability to perceive the Ebbinghaus illusion appears to vary dramatically among vertebrate species, and even populations, but this may depend on whether the viewing distance is restricted. We tested whether honeybees perceive contextual size illusions, and whether errors in perception of size differed under restricted and unrestricted viewing conditions...
November 29, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29167367/embryonic-origin-of-the-gnathostome-vertebral-skeleton
#16
Katharine E Criswell, Michael I Coates, J Andrew Gillis
The vertebral column is a key component of the jawed vertebrate (gnathostome) body plan, but the primitive embryonic origin of this skeleton remains unclear. In tetrapods, all vertebral components (neural arches, haemal arches and centra) derive from paraxial mesoderm (somites). However, in teleost fishes, vertebrae have a dual embryonic origin, with arches derived from somites, but centra formed, in part, by secretion of bone matrix from the notochord. Here, we test the embryonic origin of the vertebral skeleton in a cartilaginous fish (the skate, Leucoraja erinacea) which serves as an outgroup to tetrapods and teleosts...
November 29, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29167335/%C3%AE-d-n-4-hydroxycytidine-is-a-potent-anti-alphavirus-compound-that-induces-high-level-of-mutations-in-viral-genome
#17
Nadya Urakova, Valeriya Kuznetsova, David K Crossman, Arpine Sokratian, David B Guthrie, Alexander A Kolykhalov, Mark A Lockwood, Michael G Natchus, Michael R Crowley, George R Painter, Elena I Frolova, Ilya Frolov
Venezuelan equine encephalitis virus (VEEV) is a representative member of the New World alphaviruses. It is transmitted by mosquito vectors and causes highly debilitating disease in humans, equides and other vertebrate hosts. Despite a continuous public health threat, very few compounds with anti-VEEV activity in cell culture and in mouse models have been identified to date, and rapid development of virus resistance to some of them has been recorded. In this study, we investigated the possibility of using a modified nucleoside analog, β-D-N(4)-hydroxycytidine (NHC), as an anti-VEEV agent and defined the mechanism of its anti-VEEV activity...
November 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29167230/absence-of-cd59-in-guinea-pigs-analysis-of-the-cavia-porcellus-genome-suggests-the-evolution-of-a-cd59-pseudogene
#18
Hani Boshra, Wioleta M Zelek, Timothy R Hughes, Santiago Rodriguez de Cordoba, B Paul Morgan
CD59 is a membrane-bound regulatory protein that inhibits the assembly of the terminal membrane attack complex (C5b-9) of complement. From its original discovery in humans almost 30 years ago, CD59 has been characterized in a variety of species, from primates to early vertebrates, such as teleost fish. CD59 is ubiquitous in mammals; however, we have described circumstantial evidence suggesting that guinea pigs (Cavia porcellus) lack CD59, at least on erythrocytes. In this study, we have used a combination of phylogenetic analyses with syntenic alignment of mammalian CD59 genes to identify the only span of genomic DNA in C...
November 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29167220/iatrogenic-injury-of-vertebral-artery-resulting-in-stroke-after-central-venous-line-insertion
#19
Vindya Abeysinghe, Jie Hua Xu, Kishore Sieunarine
There are many complications of central venous catheter insertion. Iatrogenic injury of the vertebral artery is a rare complication that can result in severe morbidity and mortality. The case presented describes the complication of an acute ischaemic stroke after cannulation of the vertebral artery. There are various techniques when obtaining central access, however the best practice as described by the evidence based guidelines produced by the American Society of Anesthesiologists utilises real-time ultrasound guidance to minimise adverse events...
November 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29166572/territorial-aggression-in-urban-and-rural-song-sparrows-is-correlated-with-corticosterone-but-not-testosterone
#20
Scott Davies, Michelle L Beck, Kendra B Sewall
Urban songbirds of several species more vigorously defend their territories in response to conspecific song playback than do their rural counterparts, but the hormonal basis of this behavioral difference is unclear. It is well established in vertebrates that both testosterone and corticosterone affect the intensity of territoriality. Previous studies have found no evidence that initial (i.e., immediately follow territorial challenge, but prior to restraint) plasma testosterone accounts for the elevated territorial aggression of urban birds...
November 19, 2017: Hormones and Behavior
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