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https://www.readbyqxmd.com/read/28738168/role-of-age-and-injury-mechanism-in-cervical-spine-injury-tolerance-under-head-contact-loading
#1
Narayan Yoganandan, Sajal Chirvi, Liming Voo, Frank A Pintar, Anjishnu Banerjee
OBJECTIVE: To determine the influence of age on cervical spine tolerance to injury from head contact loading using survival analysis. METHODS: This study analyzed data from previously conducted experiments using Post Mortem Human Subject specimens (PMHS). Group A tests used the upright intact head-cervical column experimental model. The inferior end of the specimen was fixed, head was balanced by a mechanical system, and natural lordosis was removed. Specimens were placed on a testing device via a load cell...
July 24, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28738066/expansion-by-whole-genome-duplication-and-evolution-of-the-sox-gene-family-in-teleost-fish
#2
Emilien Voldoire, Frédéric Brunet, Magali Naville, Jean-Nicolas Volff, Delphine Galiana
It is now recognized that several rounds of whole genome duplication (WGD) have occurred during the evolution of vertebrates, but the link between WGDs and phenotypic diversification remains unsolved. We have investigated in this study the impact of the teleost-specific WGD on the evolution of the sox gene family in teleostean fishes. The sox gene family, which encodes for transcription factors, has essential role in morphology, physiology and behavior of vertebrates and teleosts, the current largest group of vertebrates...
2017: PloS One
https://www.readbyqxmd.com/read/28737577/vertebral-myeloma-mimicking-prostatic-carcinoma-metastasis-in-68ga-psma-pet-ct
#3
Esben Hoej Merrild, Steen Baerentzen, Kirsten Bouchelouche, Simon Buus
Ga-PSMA PET/CT was performed in a 75-year-old man with newly diagnosed prostate cancer because of an equivocal lesion in the spine both on Tc-bone-SPECT/CT and MRI. Because of increased PSMA activity on PET/CT, the bone lesion was interpreted as metastasis from prostate cancer. Later, the patient was diagnosed as having monoclonal gammopathy of unknown significance. A biopsy was performed, and histological examination revealed multiple myeloma with PSMA expression in the neovessels but no metastatic prostate cancer cells...
July 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28737193/-vertebral-fractures-in-children-with-type-i-osteogenesis-imperfecta
#4
Andrea M Sepúlveda, Claudia V Terrazas, Josefina Sáez, María L Reyes
Osteogenesis imperfecta (OI) is an hereditary disease affecting conective tissue, mainly associated to growth retardation and pathological fractures. OI type I (OI type I), is the mildest, most often, and homogeneous in its fenotype. Vertebral fractures are the most significant complications, associated to skeletical and cardiopulmonary morbidity. OBJECTIVES: To characterize clinically a cohort of children with OI type I. PATIENTS AND METHODS: A cohort of OI type I children younger than 20 year old was evaluated...
June 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28737063/genetic-diversity-and-antimicrobial-resistance-profile-of-enterococcus-faecalis-isolated-from-broilers-with-vertebral-osteomyelitis-in-southeast-brazil
#5
Juliana Fortes Vilarinho Braga, Carlos Augusto Gomes Leal, Camila Costa Silva, André Almeida Fernandes, Nelson Rodrigo da Silva Martins, Roselene Ecco
Vertebral osteomyelitis (VO) is a worldwide emerging disease that affects broilers. Recently, the isolation of Enterococcus faecalis in cases of the disease has been described. This study aimed at determining the genetic diversity and antimicrobial resistance profile of 12 Enterococcus faecalis strains isolated from broilers with VO. Strains were isolated from nine flocks from six farms in a high-density poultry production area in Southeast Brazil and were evaluated using multilocus sequence typing (MLST) and phylogenetic analysis...
July 24, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28737013/anatomic-variations-of-neck-vessels-and-the-course-of-pediatric-internal-jugular-veins
#6
Kai-Ming Yuan, En-Ci Liu, Ping Li, Wang-Ning Shangguan, Jun Li, Qing-Quan Lian
BACKGROUND: Landmark-guided internal jugular vein cannulation is difficult for pediatric patients but useful, especially when ultrasound equipment is unavailable. Therefore, it is important to define the adjacent anatomic characteristics of the pediatric internal jugular vein. METHODS: In 210 children the course of the internal jugular vein, and common carotid and vertebral arteries was measured from the level of the cricoid cartilage to the supraclavicular area using ultrasound...
July 24, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28736858/position-and-relative-size-of-the-vertebral-artery-according-to-age-implications-for-internal-jugular-vein-access
#7
Chul-Woo Jung, Gulomjon Jalilov, In-Kyung Song, Eun-Hee Kim, Hee-Soo Kim, Jin-Tae Kim, Ji-Hyun Lee
AIM: The purpose of this retrospective observational study was to investigate the anatomical characteristics of the vertebral artery in pediatric patients using computed tomography images. METHODS: We evaluated anatomical characteristics of the right and left vertebral artery at the cricoid level and at a lower level, which was mid-level between the cricoid cartilage and the origin of vertebral artery from the subclavian artery. At each level, the cross-sectional areas of the vertebral artery and internal jugular vein, the relative size of vertebral artery to internal jugular vein, the minimum distance between them, and the extent of overlap between them were investigated...
July 24, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28736621/percutaneous-cement-augmentation-for-osteoporotic-vertebral-fractures
#8
REVIEW
Amer Sebaaly, Maroun Rizkallah, Falah Bachour, Firas Atallah, Pierre Emmanuel Moreau, Ghassan Maalouf
Thoracolumbar vertebral fracture incidents usually occur secondary to a high velocity trauma in young patients and to minor trauma or spontaneously in older people.Osteoporotic vertebral fractures are the most common osteoporotic fractures and affect one-fifth of the osteoporotic population.Percutaneous fixation by 'vertebroplasty' is a tempting alternative for open surgical management of these fractures.Despite discouraging initial results of early trials for vertebroplasty, cement augmentation proved its superiority for the treatment of symptomatic osteoporotic vertebral fracture when compared with optimal medical treatment...
June 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28736437/dissecting-evolution-and-disease-using-comparative-vertebrate-genomics
#9
REVIEW
Jennifer R S Meadows, Kerstin Lindblad-Toh
With the generation of more than 100 sequenced vertebrate genomes in less than 25 years, the key question arises of how these resources can be used to inform new or ongoing projects. In the past, this diverse collection of sequences from human as well as model and non-model organisms has been used to annotate the human genome and to increase the understanding of human disease. In the future, comparative vertebrate genomics in conjunction with additional genomic resources will yield insights into the processes of genome function, evolution, speciation, selection and adaptation, as well as the quantification of species diversity...
July 24, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28736374/-low-cement-distribution-index-is-a-risk-factor-for-refracture-of-the-adjacent-segments-after-percutaneous-vertebroplasty
#10
Zhao-Zong Fu, Zhong-Xian Chen, Ying Qin, Zhi-Qiang Feng, Xiong-Jian Jiang, Qing-Hua Xie, Yi-Tao Liu
OBJECTIVE: To investigate the impact of cement distribution index on the occurrence of refracture in the adjacent segments after percutaneous vertebroplasty. METHODS: This retrospective analysis was conducted among 143 patients who received percutaneous vertebroplasty for osteoporotic vertebral compression fracture between April, 2011 and April, 2014. Of the 134 patients with complete follow-up data, 18 had adjacent segment fracture within 1 year following the surgeries (re-fracture group), and 116 patients without new fracture served as the control group...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28736355/c2-bone-erosion-secondary-to-iatrogenic-pseudomeningocele-a-case-report-and-description-of-a-novel-surgical-technique
#11
Stephan N Salzmann, Lukas P Lampe, Brian Fernholz, Roger Härtl, Athos Patsalides, Alexander P Hughes
BACKGROUND: Pseudomeningoceles are a rare cause of bone erosions. Development of such erosions in the C2 vertebral body and the odontoid process can lead to life-threatening instability. Treatment options to regain stability include atlantoaxial and occipitocervical fusion. For patients with a history of Chiari decompression and large C2 lesions, common fusion techniques are not always feasible. Additionally fusion surgery sacrifices physiologic motion and is therefore a disabling procedure, especially for young and active patients...
July 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28736226/rapid-effects-of-the-aromatase-inhibitor-fadrozole-on-steroid-production-and-gene-expression-in-the-ovary-of-female-fathead-minnows-pimephales-promelas
#12
Anthony L Schroeder, Gerald T Ankley, Tanwir Habib, Natalia Garcia-Reyero, Barbara L Escalon, Kathleen M Jensen, Michael D Kahl, Elizabeth J Durhan, Elizabeth A Makynen, Jenna E Cavallin, Dalma Martinovic-Weigelt, Edward J Perkins, Daniel L Villeneuve
Cytochrome P450 aromatase catalyzes conversion of C19 androgens to C18 estrogens and is critical for normal reproduction in female vertebrates. Fadrozole is a model aromatase inhibitor that has been shown to suppress estrogen production in the ovaries of fish. However, little is known about the early impacts of aromatase inhibition on steroid production and gene expression in fish. Adult female fathead minnows (Pimephales promelas) were exposed via water to 0, 5, or 50 µg fadrozole/L for a time-course of 0...
July 20, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28735973/in-vitro-study-on-the-regulation-of-cellular-mrna-levels-by-changes-in-transcription-rate-and-transcript-stability-in-fish-red-blood-cells
#13
Miriam Götting, Mikko Nikinmaa
The interplay of transcriptional and posttranscriptional processes in the regulation of gene expression has been extensively studied in mammals but little is known in other vertebrates so far. Most non-mammalian vertebrates are faced with environmental cues and stressors distinct from those experienced by mammals and thus it is likely that the gene expression strategies differ from those of mammals. Here we performed experiments to study in vitro the various levels of gene expression regulation in nucleated fish red blood cells...
July 20, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28735766/risk-factor-analysis-for-predicting-vertebral-body-re-collapse-after-posterior-instrumented-fusion-in-thoracolumbar-burst-fracture
#14
Hae-Dong Jang, Jae Chul Lee, Jae-Wan Soh, Sung-Woo Choi, Hyeung-Kyu Cho, Byung-Joon Shin
BACKGROUND CONTEXT: In the posterior instrumented fusion surgery for thoracolumbar (T-L) burst fracture, early postoperative re-collapse of well-reduced vertebral body fracture could induces critical complications such as correction loss, post-traumatic kyphosis, metal failure, often lead to revision surgery. Furthermore, re-collapse is quite difficult to predict because of the variety of risk factors and no widely accepted accurate prediction systems existed. Although load sharing classification (LSC) has been known to help to decide the need for additional anterior column support, this radiographic scoring system has several critical limitations...
July 20, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28735517/metallothionein-expression-and-synthesis-in-the-testis-of-the-lizard-podarcis-sicula-under-natural-conditions-and-following-estrogenic-exposure
#15
Mariailaria Verderame, Ermelinda Limatola, Rosaria Scudiero
Metallothionein (MT) is the main protein involved in the homeostasis of metallic micronutrients and in cellular defence against heavy metals and reactive oxygen species. Found in almost all vertebrate tissues, MT presence and localization in the testis has been controversial. In the present study, by using in situ hybridization and immunohistochemical analysis we assessed the localization of both MT transcript and protein in Podarcis sicula testes during two different phases of the reproductive cycle: the autumnal resumption and the spring-early summer mating period...
May 3, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28735443/retinoic-acid-regulates-avian-lung-branching-through-a-molecular-network
#16
Hugo Fernandes-Silva, Patrícia Vaz-Cunha, Violina Baranauskaite Barbosa, Carla Silva-Gonçalves, Jorge Correia-Pinto, Rute Silva Moura
Retinoic acid (RA) is of major importance during vertebrate embryonic development and its levels need to be strictly regulated otherwise congenital malformations will develop. Through the action of specific nuclear receptors, named RAR/RXR, RA regulates the expression of genes that eventually influence proliferation and tissue patterning. RA has been described as crucial for different stages of mammalian lung morphogenesis, and as part of a complex molecular network that contributes to precise organogenesis; nonetheless, nothing is known about its role in avian lung development...
July 22, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28735442/mechanisms-regulating-dendritic-arbor-patterning
#17
REVIEW
Fernanda Ledda, Gustavo Paratcha
The nervous system is populated by diverse types of neurons, each of which has dendritic trees with strikingly different morphologies. These neuron-specific morphologies determine how dendritic trees integrate thousands of synaptic inputs to generate different firing properties. To ensure proper neuronal function and connectivity, it is necessary that dendrite patterns are precisely controlled and coordinated with synaptic activity. Here, we summarize the molecular and cellular mechanisms that regulate the formation of cell type-specific dendrite patterns during development...
July 22, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28735136/spinal-instability-predictive-scoring-system-for-subsequent-fractures-after-bone-cement-augmentation-in-patients-with-osteoporotic-vertebral-compression-fractures
#18
Heun Sung Kim, Chang Il Ju
OBJECTIVE: Bone cement augmentation procedures (vertebroplasty and kyphoplasty) are the primary treatments for osteoporotic vertebral compression fractures (VCFs). However, these procedures are associated with various problems resulting in subsequent fractures. The purpose of this study was to evaluate the spinal instability factors related to subsequent fractures after vertebral augmentation procedures. METHODS: We retrospectively reviewed patients who underwent augmentation procedures for osteoporotic VCFs...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735128/a-ct-based-comparison-of-abnormal-vertebrae-pedicles-between-dystrophic-and-nondystrophic-scoliosis-in-neurofibromatosis-type-1
#19
Ying Li, Ming Luo, Wengang Wang, Mingkui Shen, Genzhong Xu, Jianbo Gao, Lei Xia
OBJECTIVE: To explore the prevalence and distribution of abnormal vertebral pedicles in scoliosis secondary to neurofibromatosis type 1 (NF1-S) and to compare the abnormal vertebrae pedicles between dystrophic and nondystrophic scoliosis. METHODS: We carefully measured 2,652 vertebral pedicles from 56 NF1-S patients with dystrophic scoliosis and 22 NF1-S patients with nondystrophic scoliosis using CT images. Pedicle morphology was classified as follows: type A, a cancellous channel of > 4 mm; type B, a cancellous channel of 2 to 4 mm; type C, a cancellous channel of < 2 mm with an entirely cortical channel of ≥ 2 mm; type D, a cortical channel of < 2 mm; or type E, absent pedicle...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28734934/analysis-of-rna-protein-interactions-in-vertebrate-embryos-using-uv-crosslinking-approaches
#20
Vladimir Despic, Mario Dejung, Falk Butter, Karla M Neugebauer
A decade ago, we believed that at least 300 RNA binding proteins (RBPs) were encoded in our genomes based on annotations of known or predicted RNA binding domains. Deciphering the roles of those RBPs in regulated gene expression was a vast frontier awaiting exploration. Since then, the field has developed a number of key tools that navigate the landscape of cellular RNA. These rely principally on UV crosslinking to create covalent bonds between RBPs and target RNAs in vivo, revealing not only target identities but also local binding sites upon RNA-Seq...
July 19, 2017: Methods: a Companion to Methods in Enzymology
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