Yulia S Vershinina, George S Krasnov, David G Garbuz, Mikhail V Shaposhnikov, Maria S Fedorova, Elena A Pudova, Irina V Katunina, Alexey B Kornev, Nadezhda V Zemskaya, Alexander A Kudryavtsev, Elizaveta V Bulavkina, Anna A Matveeva, Natalia S Ulyasheva, Zulfiya G Guvatova, Artemiy A Anurov, Alexey A Moskalev, Anna V Kudryavtseva
Torin-2, a synthetic compound, is a highly selective inhibitor of both TORC1 and TORC2 (target of rapamycin) complexes as an alternative to the well-known immunosuppressor, geroprotector, and potential anti-cancer natural compound rapamycin. Torin-2 is effective at hundreds of times lower concentrations and prevents some negative side effects of rapamycin. Moreover, it inhibits the rapamycin-resistant TORC2 complex. In this work, we evaluated transcriptomic changes in D. melanogaster heads induced with lifetime diets containing Torin-2 and suggested possible neuroprotective mechanisms of Torin-2...
May 22, 2023: International Journal of Molecular Sciences