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https://www.readbyqxmd.com/read/29871910/lgl-reduces-endosomal-vesicle-acidification-and-notch-signaling-by-promoting-the-interaction-between-vap33-and-the-v-atpase-complex
#1
Marta Portela, Liu Yang, Sayantanee Paul, Xia Li, Alexey Veraksa, Linda M Parsons, Helena E Richardson
Epithelial cell polarity is linked to the control of tissue growth and tumorigenesis. The tumor suppressor and cell polarity protein lethal-2-giant larvae (Lgl) promotes Hippo signaling and inhibits Notch signaling to restrict tissue growth in Drosophila melanogaster Notch signaling is greater in lgl mutant tissue than in wild-type tissue because of increased acidification of endosomal vesicles, which promotes the proteolytic processing and activation of Notch by γ-secretase. We showed that the increased Notch signaling and tissue growth defects of lgl mutant tissue depended on endosomal vesicle acidification mediated by the vacuolar adenosine triphosphatase (V-ATPase)...
June 5, 2018: Science Signaling
https://www.readbyqxmd.com/read/29775737/deltex-interacts-with-eiger-and-consequently-influences-the-cell-death-in-drosophila-melanogaster
#2
Debdeep Dutta, Ankita Singh, Maimuna Sali Paul, Vartika Sharma, Mousumi Mutsuddi, Ashim Mukherjee
TNF-JNK signaling is one of the highly conserved signaling pathways that regulate a broad spectrum of cellular processes including proliferation and apoptosis. Eiger, the sole homologue of TNF in Drosophila, initiates the TNF-JNK pathway to induce cell death. Previously, Deltex (Dx) has been identified as a Notch signaling component that regulates vesicular trafficking of Notch. In the present study, we have investigated the interaction between these two proteins in order to identify how Dx influences the activity of Eiger...
May 15, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29773559/serrate-notch-signaling-regulates-the-size-of-the-progenitor-cell-pool-in-drosophila-imaginal-rings
#3
Sheng-An Yang, Wu-Min Deng
Drosophila imaginal rings are larval tissues composed of progenitor cells that are essential for the formation of adult foreguts, hindguts and salivary glands. Specified from subsets of ectoderm in the embryo, imaginal ring cells are kept quiescent until mid-second larval instar, and undergo rapid proliferation during the third instar to attain adequate numbers of cells that will replace apoptotic larval tissues for adult organ formation. Here we show that Notch signaling is activated in all three imaginal rings from middle embryonic stage to early pupal stage and that Notch signaling positively controls cell proliferation in all three imaginal rings during the third larval instar...
May 17, 2018: Genetics
https://www.readbyqxmd.com/read/29764857/lineage-guided-notch-dependent-gliogenesis-by-drosophila-multi-potent-progenitors
#4
Qingzhong Ren, Takeshi Awasaki, Yu-Chun Wang, Yu-Fen Huang, Tzumin Lee
Macroglial cells in the central nervous system exhibit regional specialization and carry out region-specific functions. Diverse glial cells arise from specific progenitors in specific spatiotemporal patterns. This raises an interesting possibility that there exist glial precursors with distinct developmental fates, which govern region-specific gliogenesis. Here we mapped the glial progeny produced by the Drosophila type II neuroblasts, which, like vertebrate radial glia cells, yield both neurons and glia via intermediate neural progenitors (INPs)...
May 15, 2018: Development
https://www.readbyqxmd.com/read/29755433/-de-novo-dna-synthesis-in-aedes-aegypti-midgut-cells-as-a-complementary-strategy-to-limit-dengue-viral-replication
#5
Javier Serrato-Salas, Salvador Hernández-Martínez, Jesús Martínez-Barnetche, Renaud Condé, Alejandro Alvarado-Delgado, Federico Zumaya-Estrada, Humberto Lanz-Mendoza
Aedes aegypti is the main vector of Dengue Virus, carrying the virus during the whole mosquito life post-infection. Few mosquito fitness costs have been associated to the virus infection, thereby allowing for a swift dissemination. In order to diminish the mosquito population, public health agency use persistent chemicals with environmental impact for disease control. Most countries barely use biological controls, if at all. With the purpose of developing novel Dengue control strategies, a detailed understanding of the unexplored virus-vector interactions is urgently needed...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29681543/the-pou-oct-transcription-factor-nubbin-controls-the-balance-of-intestinal-stem-cell-maintenance-and-differentiation-by-isoform-specific-regulation
#6
Xiongzhuo Tang, Yunpo Zhao, Nicolas Buchon, Ylva Engström
Drosophila POU/Oct transcription factors are required for many developmental processes, but their putative regulation of adult stem cell activity has not been investigated. Here, we show that Nubbin (Nub)/Pdm1, homologous to mammalian OCT1/POU2F1 and related to OCT4/POU5F1, is expressed in gut epithelium progenitor cells. We demonstrate that the nub-encoded protein isoforms, Nub-PB and Nub-PD, play opposite roles in the regulation of intestinal stem cell (ISC) maintenance and differentiation. Depletion of Nub-PB in progenitor cells increased ISC proliferation by derepression of escargot expression...
May 8, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29677185/patterning-mechanisms-diversify-neuroepithelial-domains-in-the-drosophila-optic-placode
#7
Abhishek Kumar Mishra, F Javier Bernardo-Garcia, Cornelia Fritsch, Tim-Henning Humberg, Boris Egger, Simon G Sprecher
The central nervous system develops from monolayered neuroepithelial sheets. In a first step patterning mechanisms subdivide the seemingly uniform epithelia into domains allowing an increase of neuronal diversity in a tightly controlled spatial and temporal manner. In Drosophila, neuroepithelial patterning of the embryonic optic placode gives rise to the larval eye primordium, consisting of two photoreceptor (PR) precursor types (primary and secondary), as well as the optic lobe primordium, which during larval and pupal stages develops into the prominent optic ganglia...
April 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29661224/notch-signals-modulate-lgl-mediated-tumorigenesis-by-the-activation-of-jnk-signaling
#8
Maimuna Sali Paul, Ankita Singh, Debdeep Dutta, Mousumi Mutsuddi, Ashim Mukherjee
OBJECTIVES: Oncogenic potential of Notch signaling and its cooperation with other factors to affect proliferation are widely established. Notch exhibits a cooperative effect with loss of a cell polarity gene, scribble to induce neoplastic overgrowth. Oncogenic Ras also show cooperative effect with loss of cell polarity genes such as scribble (scrib), lethal giant larvae (lgl) and discs large to induce neoplastic overgrowth and invasion. Our study aims at assessing the cooperation of activated Notch with loss of function of lgl in tumor overgrowth, and the mode of JNK signaling activation in this context...
April 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29629869/a-population-of-adult-satellite-like-cells-in-drosophila-is-maintained-through-a-switch-in-rna-isoforms
#9
Hadi Boukhatmi, Sarah Bray
Adult stem cells are important for tissue maintenance and repair. One key question is how such cells are specified and then protected from differentiation for a prolonged period. Investigating the maintenance of Drosophila muscle progenitors (MPs) we demonstrate that it involves a switch in zfh1/ZEB1 RNA-isoforms. Differentiation into functional muscles is accompanied by expression of miR-8/miR-200 , which targets the major zfh1-long RNA isoform and decreases Zfh1 protein. Through activity of the Notch pathway, a subset of MPs produce an alternate zfh1-short isoform, which lacks the miR-8 seed site...
April 9, 2018: ELife
https://www.readbyqxmd.com/read/29587629/comparative-analysis-of-fkbp-family-protein-evaluation-structure-and-function-in-mammals-and-drosophila-melanogaster
#10
REVIEW
George Ghartey-Kwansah, Zhongguang Li, Rui Feng, Liyang Wang, Xin Zhou, Frederic Z Chen, Meng Meng Xu, Odell Jones, Yulian Mu, Shawn Chen, Joseph Bryant, Williams B Isaacs, Jianjie Ma, Xuehong Xu
BACKGROUND: FK506-binding proteins (FKBPs) have become the subject of considerable interest in several fields, leading to the identification of several cellular and molecular pathways in which FKBPs impact prenatal development and pathogenesis of many human diseases. MAIN BODY: This analysis revealed differences between how mammalian and Drosophila FKBPs mechanisms function in relation to the immunosuppressant drugs, FK506 and rapamycin. Differences that could be used to design insect-specific pesticides...
March 27, 2018: BMC Developmental Biology
https://www.readbyqxmd.com/read/29576455/development-of-concurrent-retinotopic-maps-in-the-fly-motion-detection-circuit
#11
Filipe Pinto-Teixeira, Clara Koo, Anthony Michael Rossi, Nathalie Neriec, Claire Bertet, Xin Li, Alberto Del-Valle-Rodriguez, Claude Desplan
Understanding how complex brain wiring is produced during development is a daunting challenge. In Drosophila, information from 800 retinal ommatidia is processed in distinct brain neuropiles, each subdivided into 800 matching retinotopic columns. The lobula plate comprises four T4 and four T5 neuronal subtypes. T4 neurons respond to bright edge motion, whereas T5 neurons respond to dark edge motion. Each is tuned to motion in one of the four cardinal directions, effectively establishing eight concurrent retinotopic maps to support wide-field motion...
April 5, 2018: Cell
https://www.readbyqxmd.com/read/29514083/pi3k-akt-cooperates-with-oncogenic-notch-by-inducing-nitric-oxide-dependent-inflammation
#12
Santiago Nahuel Villegas, Rita Gombos, Lucia García-López, Irene Gutiérrez-Pérez, Jesús García-Castillo, Diana Marcela Vallejo, Vanina Gabriela Da Ros, Esther Ballesta-Illán, József Mihály, Maria Dominguez
The PI3K/Akt signaling pathway, Notch, and other oncogenes cooperate in the induction of aggressive cancers. Elucidating how the PI3K/Akt pathway facilitates tumorigenesis by other oncogenes may offer opportunities to develop drugs with fewer side effects than those currently available. Here, using an unbiased in vivo chemical genetic screen in Drosophila, we identified compounds that inhibit the activity of proinflammatory enzymes nitric oxide synthase (NOS) and lipoxygenase (LOX) as selective suppressors of Notch-PI3K/Akt cooperative oncogenesis...
March 6, 2018: Cell Reports
https://www.readbyqxmd.com/read/29509808/complex-genetic-interactions-of-novel-suppressor-of-hairless-alleles-deficient-in-co-repressor-binding
#13
Anette Preiss, Anja C Nagel, Heiko Praxenthaler, Dieter Maier
Throughout the animal kingdom, the Notch signalling pathway allows cells to acquire diversified cell fates. Notch signals are translated into activation of Notch target genes by CSL transcription factors. In the absence of Notch signals, CSL together with co-repressors functions as a transcriptional repressor. In Drosophila, repression of Notch target genes involves the CSL homologue Suppressor of Hairless (Su(H)) and the Notch (N) antagonist Hairless (H) that together form a repressor complex. Guided by crystal structure, three mutations Su(H)LL, Su(H)LLF and Su(H)LLL were generated that specifically affect interactions with the repressor H, and were introduced into the endogenous Su(H) locus by gene engineering...
2018: PloS One
https://www.readbyqxmd.com/read/29504896/transcriptome-analysis-reveals-mechanisms-of-geroprotective-effects-of-fucoxanthin-in-drosophila
#14
Alexey Moskalev, Mikhail Shaposhnikov, Nadezhda Zemskaya, Alexey Belyi, Eugenia Dobrovolskaya, Anna Patova, Zulfiya Guvatova, Elena Lukyanova, Anastasiya Snezhkina, Anna Kudryavtseva
BACKGROUND: We have previously showed that the carotenoid fucoxanthin can increase the lifespan in Drosophila melanogaster and Caenorhabditis elegans. However, the molecular mechanisms of the geroprotective effect of fucoxanthin have not been studied so far. RESULTS: Here, we studied the effects of fucoxanthin on the Drosophila aging process at the molecular and the whole organism levels. At the organismal level, fucoxanthin increased the median lifespan and had a positive effect on fecundity, fertility, intestinal barrier function, and nighttime sleep...
February 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29467404/basal-condensation-of-numb-and-pon-complex-via-phase-transition-during-drosophila-neuroblast-asymmetric-division
#15
Zelin Shan, Yuting Tu, Ying Yang, Ziheng Liu, Menglong Zeng, Huisha Xu, Jiafu Long, Mingjie Zhang, Yu Cai, Wenyu Wen
Uneven distribution and local concentration of protein complexes on distinct membrane cortices is a fundamental property in numerous biological processes, including Drosophila neuroblast (NB) asymmetric cell divisions and cell polarity in general. In NBs, the cell fate determinant Numb forms a basal crescent together with Pon and is segregated into the basal daughter cell to initiate its differentiation. Here we discover that Numb PTB domain, using two distinct binding surfaces, recognizes repeating motifs within Pon in a previously unrecognized mode...
February 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29453546/a-drosophila-model-to-decipher-the-toxicity-of-nanoparticles-taken-through-oral-routes
#16
S Aurosman Pappus, Monalisa Mishra
In recent era, nanoparticles (NPs) are widely used in food, medicine and body implants. Besides it's wide use being a foreign particle it may have some noxious effect on the body. To understand the mechanistic role of NPs toxicity, Drosophila appeared to be a superior model organism. Toxicity of several nanoparticles were accessed using Drosophila. The NPs, after oral route of exposure enter into the gut, crosses the barrier of peritrophic membrane and induces apoptosis. The toxicity of NPs within gut resulted in developmental delay, with decrease in pupa count, fly hatching along with weight loss...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29437009/the-bhlh-protein-nulp1-is-essential-for-femur-development-via-acting-as-a-cofactor-in-wnt-signaling-in-drosophila
#17
Q Zeng, Y Wan, P Zhu, M Zhao, F Jiang, J Chen, M Tang, X Zhu, Y Li, H Zha, Y Wang, M Hu, X Mo, Y Zhang, Y Chen, Y Chen, X Ye, R Bodmer, K Ocorr, Z Jiang, J Zhuang, W Yuan, X Wu
BACKGROUND: The basic helix-loop-helix (bHLH) protein families are a large class of transcription factors, which are associated with cell proliferation, tissue differentiation, and other important development processes. We reported that the Nuclear localized protein-1 (Nulp1) might act as a novel bHLH transcriptional factor to mediate cellular functions. However, its role in development in vivo remains unknown. METHODS: Nulp1 (dNulp1) mutants are generated by CRISPR/Cas9 targeting the Domain of Unknown Function (DUF654) in its C terminal...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29408269/aedes-aegypti-antiviral-adaptive-response-against-denv-2
#18
Javier Serrato-Salas, Javier Izquierdo-Sánchez, Martha Argüello, Renáud Conde, Alejandro Alvarado-Delgado, Humberto Lanz-Mendoza
Priming is the conceptual term defining memory phenomenon in innate immune response. Numerous examples of enhanced secondary immune response have been described in diverse taxa of invertebrates; which naturally lacks memory response. In mosquitoes, a previous non-lethal challenge with some specific pathogens modify their immune response against the same microorganism; developing an improved antimicrobial reaction. In this work, we explore the ability of Aedes aegypti to mount a higher antiviral response upon a second oral DENV challenge...
July 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29374056/a-dual-role-of-the-extracellular-domain-of-drosophila-crumbs-for-morphogenesis-of-the-embryonic-neuroectoderm
#19
Shradha Das, Elisabeth Knust
Epithelia are highly polarised tissues and several highly conserved polarity protein complexes serve to establish and maintain polarity. The transmembrane protein Crumbs (Crb), the central component of the Crb protein complex, is required, among others, for the maintenance of polarity in most epithelia in the Drosophila embryo. However, different epithelia exhibit different phenotypic severity upon loss of crb Using a transgenomic approach allowed us to more accurately define the role of crb in different epithelia...
January 26, 2018: Biology Open
https://www.readbyqxmd.com/read/29364239/cell-aggregation-assays-to-evaluate-the-binding-of-the-drosophila-notch-with-trans-ligands-and-its-inhibition-by-cis-ligands
#20
Ashutosh Pandey, Hamed Jafar-Nejad
Notch signaling is an evolutionarily conserved cell-cell communication system used broadly in animal development and adult maintenance. Interaction of the Notch receptor with ligands from neighboring cells induces activation of the signaling pathway (trans-activation), while interaction with ligands from the same cell inhibits signaling (cis-inhibition). Proper balance between trans-activation and cis-inhibition helps establish optimal levels of Notch signaling in some contexts during animal development. Because of the overlapping expression domains of Notch and its ligands in many cell types and the existence of feedback mechanisms, studying the effects of a given post-translational modification on trans- versus cis-interactions of Notch and its ligands in vivo is difficult...
January 2, 2018: Journal of Visualized Experiments: JoVE
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