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Lingli Hu, Zhencheng Liao, Qiqi Hu, Katherine G Maffucci, Yan Qu
Dissolving microneedles (MNs) have been widely studied for their applications in effective transdermal drug delivery due to their ability to dissolve within the skin. This study details the first reported successful preparation of novel dissolving MNs using Bletilla striata polysaccharide (BSP), a natural glucomannan material, and investigates the potential for using such MNs as a transdermal drug delivery vector. The prepared dissolving Bletilla striata polysaccharide microneedles (BMNs) had excellent moldability and were easily detached from the mold...
May 15, 2018: International Journal of Biological Macromolecules
Philip J Cobb, David J Moulding, Fabrizio Ortu, Simon Randall, Ashley J Wooles, Louise S Natrajan, Stephen T Liddle
We report the preparation of a range of alkali metal uranyl(VI) tri- bis(silyl)amide complexes [{M(THF) x }{(μ-O)U(O)(N″)3 }] (1M) (N″ = {N(SiMe3 )2 }- , M = Li, Na, x = 2; M = K, x = 3; M = K, Rb, Cs, x = 0) containing electrostatic alkali metal uranyl-oxo interactions. Reaction of 1M with 2,2,2-cryptand or 2 equiv of the appropriate crown ether resulted in the isolation of the separated ion pair species [U(O)2 (N″)3 ][M(2,2,2-cryptand)] (3M, M = Li-Cs) and [U(O)2 (N″)3 ][M(crown)2 ] (4M, M = Li, crown = 12-crown-4 ether; M = Na-Cs, crown = 15-crown-5 ether)...
May 18, 2018: Inorganic Chemistry
Thomas Rasmussen, Bjarke Follin, Jens Kastrup, Malene Brandt-Larsen, Jacob Madsen, Thomas Emil Christensen, Morten Juhl, Smadar Cohen, Karsten Pharao Hammelev, Christian Holdflod Møller, Jens Peter Goetze, Philip Hasbak, Andreas Kjær
Angiogenesis is considered integral to the reparative process after ischemic injury. The αv β₃ integrin is a critical modulator of angiogenesis and highly expressed in activated endothelial cells. 68 Ga-NODAGA-E[(cRGDyK)]₂ (RGD) is a positron-emission-tomography (PET) ligand targeted towards αv β₃ integrin. The aim was to present data for the uptake of RGD and correlate it with histology and to further illustrate the differences in angiogenesis due to porcine adipose-derived mesenchymal stromal cell (pASC) or saline treatment in minipigs after induction of myocardial infarction (MI)...
May 16, 2018: Diagnostics
Marta Obara-Michlewska, Fengfei Ding, Mariusz Popek, Alexei Verkhratsky, Maiken Nedergaard, Magdalena Zielinska, Jan Albrecht
Acute toxic liver failure (ATLF) rapidly leads to brain oedema and neurological decline. We evaluated the ability of ATLF-affected brain to control the ionic composition and acid-base balance of the interstitial fluid. ATLF was induced in 10-12 weeks old male C57Bl mice by single intraperitoneal (i.p.) injection of 100 μg/g azoxymethane (AOM). Analyses were carried out in cerebral cortex of precomatous mice 20-24 h after AOM administration. Brain fluid status was evaluated by measuring apparent diffusion coefficient [ADC] using NMR spectroscopy, Evans Blue extravasation, and accumulation of an intracisternally-injected fluorescent tracer...
May 14, 2018: Neurochemistry International
Kyle K Biggar, Kenneth B Storey
In many cases, the DNA-binding activity of a transcription factor does not change, while its transcriptional activity is greatly influenced by the make-up of bound proteins. In this study, we assessed the protein composition and DNA-binding ability of the E2F transcription factor complex to provide insight into cell cycle control in an anoxia tolerant turtle through the use of a modified ELISA protocol. This modification also permits the use of custom DNA probes that are tailored to a specific DNA binding region, introducing the ability to design capture probes for non-model organisms...
2018: PeerJ
O E Kale, O B Akinpelu, A A Bakare, F O Yusuf, R Gomba, D C Araka, T O Ogundare, A C Okolie, O Adebawo, O Odutola
BACKGROUND: This present study sought to assess the modulatory effects of five Nigerian traditional polyherbal in high fructose-fed, streptozotocin-induced (HF-STZ) Type 2 diabetes (T2D) in rats. T2D was achieved via fructose feeding (20%W/V ) ad libitum for 2 weeks and streptozotocin (STZ, 40 mg/kg) (15th Day) intraperitoneally. METHODS: Seventy-two hours after STZ injection, fourty-eight diabetic rats were divided into eight of 6 rats/group: Diabetic normal untreated, glibenclamide (GBLI, 0...
May 16, 2018: BMC Complementary and Alternative Medicine
Yu Du, Tian Yu, Zhijing Fu, Lihua Bi
Herein, two mixed-valence Mn16-containing polyanions, (Mn16) [MnIII10MnII6O6(OH)6(PO4)4(A-a-SiW9O34)4]28- (Mn16-Cs) and [MnIII4MnII12(OH)12(PO4)4(A-a-SiW9O34)4]28- (Mn16-Rb), were successfully fabricated on an indium tin oxide (ITO)-coated glass electrode and a glass carbon electrode (GCE) by a layer-by-layer assembly method. Moreover, four composite films, i.e. [PDDA/Mn16-Cs]n, [PDDA/Mn16-Rb]n, [Mn16-Cs/Rubpy]n, and [Mn16-Rb/Rubpy]n (PDDA: poly(diallyldimethylammonium chloride); Rubpy: tris(2,2'-bipyridyl)ruthenium(ii) chloride; n = 1-10), were constructed for comparison and characterized by UV-visible spectroscopy, cyclic voltammetry (CV), and X-ray photoelectron spectroscopy (XPS)...
May 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Leonard Bezinge, Richard M Maceiczyk, Ioannis Lignos, Maksym V Kovalenko, Andrew J deMello
Recent advances in the development of hybrid organic-inorganic lead halide perovskite (LHP) nanocrystals (NCs) have demonstrated their versatility and potential application as photovoltaics and light emitters through compositional tuning of optical properties. That said, due to their compositional complexity, the targeted synthesis of mixed-cation, mixed-halide LHP NCs still represents an immense challenge for traditional batch scale chemistry. To address this limitation, we herein report the integration of a high-throughput segmented-flow microfluidic reactor and self-optimizing algorithm for the synthesis of nanocrystals with defined emission properties...
May 16, 2018: ACS Applied Materials & Interfaces
Chenlong Zhao, Minghui Liu, Yongwen Li, Hongbing Zhang, Ying Li, Hao Gong, Yin Yuan, Weiting Li, Hongyu Liu, Jun Chen
BACKGROUND: Angiogenesis is an important process in the development of tumor. PD 0332991, a cell cycle inhibitor, can specifically inhibit CD4/6 phosphorylation and cell cycle progression. In xeongraft mice models, PD 0332991 treated mice had significantly decreased angiogenesis and vascular density compared with the control group, but the mechanism remains unknown. The purpose of this study is to investigate the role and molecular mechanism of PD 0332991 on vascular endothelial cells...
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Sanjay Kumar Saroj, Rajamani Nagarajan
With the dual objective of investigating the site preferences of larger sized activator ions and to append luminescence property to the perovskite structured RbZnF3 , doping of manganese(II), cerium(III), europium(III) and terbium(III) ions (5 mol%) was carried out. Although cubic symmetry of RbZnF3 was preserved for all the doped samples, site preference of rare-earth ions for the A-site Rb+ leading to an inverse perovskite arrangement has been noticed from careful analysis of lattice parameters from refinement of powder X-ray diffraction data...
May 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Federico A Gorelli, Simone De Panfilis, Taras Bryk, Lorenzo Ulivi, Gaston Garbarino, Paraskevas Parisiades, Mario Santoro
We investigated the atomic structure of liquid Rb along an isothermal path at 573 K, up to 23 GPa, by x-ray diffraction measurements. By rising pressure, we observed a liquid-liquid transformation between a simple metallic liquid, to a complex one. The transition occurs at 7.5 ± 1 GPa which is slightly above the first maximum of the T-P melting line. This transformation is traced back to the density induced hybridization of highest electronic orbitals leading to the accumulation of valence electrons between Rb atoms and to the formation of interstitial atomic shells, a behavior that Rb shares with Cs and is likely to be common to all alkali metals...
May 15, 2018: Journal of Physical Chemistry Letters
Guohong Zou, Hongil Jo, Seong-Ji Lim, Tae-Soo You, Kang Min Ok
A novel nonlinear optical (NLO) carbonatoperoxovanadate, Rb3VO(O2)2CO3, was synthesized through a simple solution-evaporation method in phase pure form. Single-crystal X-ray diffraction revealed that the structure of Rb3VO(O2)2CO3 consists of important noncentrosymmetric (NCS) chromophores, i.e., π-delocalized (CO3)2- groups, second-order Jahn-Teller (SOJT) distortive V5+ cation, and π-localized distorted O22- groups, as well as charge balancing polarizable Rb+ ions. The powder second-harmonic generation (SHG) measurements indicated that Rb3VO(O2)2CO3 is phase-matchable (Type I) and exhibits a remarkably strong SHG response of approximately 21...
May 15, 2018: Angewandte Chemie
Angeliki Marietou, Roger Chastain, Felix Beulig, Alberto Scoma, Terry C Hazen, Douglas H Bartlett
The Deepwater Horizon oil spill was one of the largest and deepest oil spills recorded. The wellhead was located at approximately 1500 m below the sea where low temperature and high pressure are key environmental characteristics. Using cells collected 4 months following the Deepwater Horizon oil spill at the Gulf of Mexico, we set up Macondo crude oil enrichments at wellhead temperature and different pressures to determine the effect of increasing depth/pressure to the in situ microbial community and their ability to degrade oil...
2018: Frontiers in Microbiology
Lei Feng, Li Chen, Junwen Yun, Zhixiang Bi, Yinghua Tang, Peipei Wu, Jibo Hou
Inclusion body hepatitis and hydropericardium-hepatitis syndrome caused by serotype 4 fowl adenovirus (FAdV-4) have emerged in China since 2013. FAdV is usually propagated in primary chicken embryonic liver cells or embryo yolk sac. The aim of this work was to develop an immortalized CEL cell line by stable expression of human mitochondrial ribosomal protein 18S-2, named CEL-hMRP18S-2 cells, for the propagation of FAdV-4. The maximum cell density of CEL-hMRP18S-2 cells could reach 2.65 × 106  cells/ml in four-days culture...
May 8, 2018: Biologicals: Journal of the International Association of Biological Standardization
El-Refaie Kenawy, Ayman A Ghfar, Saikh Mohammad Wabaidur, Moonis Ali Khan, Masoom Raza Siddiqui, Zeid A Alothman, Ayoub Abdullah Alqadami, Muhammad Hamid
Herein, Cetyltrimethyl ammonium bromide (CTAB) intercalated and branched polyhydroxystyrene (BPS) functionalized montmorillonite (MMT) nano-composite (BPS-CTAB-MMT) was developed, characterized, and its potential as an adsorbent was tested in sequestering cationic dyes viz. rhodamine B (RB), crystal violet (CV), and methylene blue (MB) from aqueous environment. N2 adsorption/desorption isotherm showed mesoporous BPS-CTAB-MMT surface with a BET surface area of 273.8 m2 /g. The appearance of sharp spikes at 2855 and 2925 cm-1 (associated with symmetric and asymmetric tensions of C - H bonds) in infra-red spectrum of BPS-CTAB-MMT indicates successful intercalation of MMT with CTAB and functionalization with BPS...
May 8, 2018: Journal of Environmental Management
Garam Kim, Jin-Young Kim, Sung-Chul Lim, Kwang Youl Lee, Okyun Kim, Hong Seok Choi
Melanoma is among the most aggressive and treatment-resistant human cancers. Aberrant histone H3 methylation at Lys 9 (H3K9) correlates with carcinogenic gene silencing, but the significance of suppressor of variegation 3-9 homolog 1 (SUV39H1), an H3K9-specific methyltransferase, in melanoma initiation and progression remains unclear. Here, we show that SUV39H1-mediated H3K9 trimethylation facilitates retinoblastoma ( RB) 1 promoter CpG island methylation by interacting with DNA methyltransferase 3A and decreasing RB mRNA and protein in melanoma cells...
May 11, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Eunhee Chung, Kaylan M Haizlip, Leslie A Leinwand
During pregnancy, the heart undergoes significant and numerous changes, including hypertrophy that are usually described as physiological and reversible. Two aspects of the cardiac response to pregnancy are relatively understudied: advanced maternal age and multiple pregnancies (multiparity). Repeated breeder mice (RB) that have undergone 5 to 7 consecutive pregnancies were sacrificed 21 days after the weaning of their last pups and were compared to age-matched primiparous, one-time pregnant mice (O1P). The ages of the old mouse groups were similar (12 {plus minus} 1 month)...
May 11, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Dongdong Wei, Yingbin Miao, Lianxia Yu, Degong Wang, Yingli Wang
A number of studies have highlighted that aberrantly expressed microRNAs (miRNAs/miRs) serve crucial roles in the tumorigenesis and tumor development of retinoblastoma (RB). Hence, a full investigation of the biological roles and regulatory mechanisms of miRNAs in RB may provide novel therapeutic targets for patients with this malignancy. miR‑198 is frequently abnormally expressed in various types of human cancers. However, the expression level, biological roles and underlying mechanisms of miR‑198 in RB remain to be elucidated...
May 7, 2018: Molecular Medicine Reports
Dongxue Chen, Jianjie Dong, Jianji Yang, Yilei Hua, Guixin Li, Chuanfei Guo, Changqing Xie, Ming Liu, Qian Liu
Materials used for outdoor radiative cooling technologies need not only be transparent in the solar spectral region, but also need to have a broadband perfect absorption in the infrared atmospheric transparency window (infrared-ATW). Silicon carbide (SiC) has been thought to be a potential candidate for such materials. However, due to the near-perfect reflection of electromagnetic waves in the whole reststrahlen band (RB) of SiC, which is within the infrared-ATW, perfect absorption in the whole RB remains a challenge...
May 11, 2018: Nanoscale
Praveen Kumar Jaiswal, Sweaty Koul, Prakash S T Shanmugam, Hari K Koul
eIF4G1, a critical component of the eIF4F complex, is required for cap-dependent mRNA translation, a process necessary for tumor growth and survival. However, the role of eIF4G1 has not been evaluated in Prostate Cancer (PCa). We observed an increased eIF4G1 protein levels in PCa tissues as compared to normal tissues. Analysis of the TCGA data revealed that eIF4G1 gene expression positively correlated with higher tumor grade and stage. Furthermore, eIF4G1 was over-expressed and or amplified, in 16% patients with metastatic PCa (SU2C/PCF Dream Team dataset) and in 59% of castration-resistant prostate cancer (CRPC) patients (Trento/Cornell/Broad dataset)...
May 10, 2018: Scientific Reports
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