keyword
MENU ▼
Read by QxMD icon Read
search

Rb

keyword
https://www.readbyqxmd.com/read/29332347/genetically-engineered-bone-marrow-derived-mesenchymal-stem-cells-co-expressing-ifn-%C3%AE-and-il-10-inhibit-hepatocellular-carcinoma-by-modulating-mapk-pathway
#1
Hao Wang, Jun Wang, Xiaolei Shi, Yitao Ding
PURPOSE: One of the major challenges in delivering cytokines for the treatment of hepatocellular carcinoma (HCC) is the mode of delivery. This study hypothesized that genetically engineered bone marrow derived mesenchymal stem cells (BMSCs) co-expressing IFN-γ and IL-10 can serve as a potential therapeutic strategy in the treatment of HCC by inhibiting cell proliferation. METHODS: Male Sprague-Dawley rats (n=5, 200-250 g) for BMSCs isolation and Nude/SCID mice (n=35,12-20g) to develop liver cancer xenograft model were used...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29330306/an-rb-family-independent-e2f3-transcription-factor-variant-impairs-stat5-signaling-and-mammary-gland-remodeling-during-pregnancy-in-mice
#2
Yang Liao, Wei Du
E2F transcription factors are regulated by binding to the retinoblastoma (Rb) tumor suppressor family of proteins. Previously, we reported an E2FLQ mutation that disrupts the binding with Rb proteins without affecting E2F's transcriptional activity. We also showed that mouse embryonic fibroblasts (MEFs) with an E2F3LQ mutation exhibit increased E2F activity and more rapid cell proliferation. In this report, we analyzed E2F3LQ mice to further characterize the in vivo consequences of Rb family-independent E2F3 activity...
January 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29328668/bis-dinitrogen-cobalt-i-complexes-with-nhc-ligation-synthesis-characterization-and-their-dinitrogen-functionalization-reactions-affording-side-on-bound-diazene-complexes
#3
Yafei Gao, Guangyu Li, Liang Deng
Late transition-metal-based catalysts are widely used in N2 fixation reactions, but the reactivity of late transition-metal N2 complexes, besides of iron N2 complexes, remained poorly understood as their N2 complexes were thought labile and hard to be functionalized. By employing a monodentate N-heterocyclic carbene (NHC), 1,3-dicyclohexyl-imidazol-2-ylidene (ICy) as ligand, the cobalt(0)- and cobalt(-1)-N2 complexes, [(ICy)3Co(N2)] (1) and [(ICy)2Co(N2)2M]n (M = K, 2a; Rb, 2b; Cs, 2c), respectively, were synthesized from the stepwise reduction of (ICy)3CoCl by the corresponding alkaline metals under a N2 atmosphere...
January 12, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29328530/fusing-planar-group-to-a-pi-bowl-electronic-and-molecular-structure-aromaticity-and-solid-state-packing-of-naphthocorannulene-and-its-anions
#4
Zheng Zhou, Sarah Spisak, Qi Xu, Andrey Rogachev, Zheng Wei, Massimo Marcaccio, Marina A Petrukhina
Molecular and electronic structure, reduction and coordination abilities of a PAH having a planar naphtho-group fused to the corannulene bowl have been investigated for the first time using a combination of theoretical and experimental tools. A direct comparison of naphtho[2,3-a]corannulene (C28H14, 1) with parent corannulene (C20H10, 2) revealed the effect of framework topology change on electronic properties and aromaticity of 1. Two reversible one-electron reduction processes with the formal reduction potentials at -2...
January 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29328447/high-mobility-group-protein%C3%A2-b1-silencing-promotes-susceptibility-of-retinoblastoma-cells-to-chemotherapeutic-drugs-through-downregulating-nuclear-factor-%C3%AE%C2%BAb
#5
Yong Chai, Juhua Xiao, Shouhua Zhang, Yunyan Du, Zhipeng Luo, Xin Zhou, Kai Huang
The aim of the present study was to investigate the effects of high-mobility group protein B1 (HMGB1) silencing on the susceptibility of retinoblastoma (RB) cells to chemotherapeutic drugs and the underlying molecular mechanisms. Western blot analysis revealed that vincristine (VCR), etoposide (ETO) and carboplatin (CBP) significantly increased the expression of HMGB1 in Weri‑Rb-1 and Y79 cells compared with the untreated control (P<0.01). siRNA HMGB1 and siRNA negative control (NC) were transfected to Y79 cells by Lipofectamine™ 2000 and, following VCR treatment, the expression of HMGB1 and nuclear factor-κB (NF-κB) was analyzed...
January 10, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29328113/spectroscopic-study-of-a-diffusion-bonded-sapphire-cell-for-hot-metal-vapors
#6
Naota Sekiguchi, Takumi Sato, Kiyoshi Ishikawa, Atsushi Hatakeyama
Characteristics of a diffusion-bonded sapphire cell for optical experiments with hot metal vapors were investigated. The sapphire cell consisted of sapphire-crystal plates and a borosilicate-glass tube, which were bonded to each other by diffusion bonding without any binders or glues. The glass tube was attached to a vacuum manifold using the standard method applied in glass processing, filled with a small amount of Rb metal by chasing with a torch, and then sealed. The cell was baked at high temperatures, and optical experiments were then performed using rubidium atoms at room temperature...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29328071/sumoylation-of-histone-deacetylase-1-regulates-myod-signaling-during-myogenesis
#7
Hosouk Joung, Sehee Kwon, Kyoung-Hoon Kim, Yun-Gyeong Lee, Sera Shin, Duk-Hwa Kwon, Yeong-Un Lee, Taewon Kook, Nakwon Choe, Jeong Chul Kim, Young-Kook Kim, Gwang Hyeon Eom, Hyun Kook
Sumoylation, the conjugation of a small ubiquitin-like modifier (SUMO) protein to a target, has diverse cellular effects. However, the functional roles of the SUMO modification during myogenesis have not been fully elucidated. Here, we report that basal sumoylation of histone deacetylase 1 (HDAC1) enhances the deacetylation of MyoD in undifferentiated myoblasts, whereas further sumoylation of HDAC1 contributes to switching its binding partners from MyoD to Rb to induce myocyte differentiation. Differentiation in C2C12 skeletal myoblasts induced new immunoblot bands above HDAC1 that were gradually enhanced during differentiation...
January 12, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29327187/does-biochar-affect-the-availability-and-chemical-fractionation-of-phosphate-in-soils
#8
Can Hong, Shenggao Lu
Biochar as a soil amendment has been reported to affect the content and availability of soil nutrients. In this study, we aimed to test whether the biochar addition to soils would change the availability and chemical fractionation of phosphate in soils. Two soils (Ultisol and Alfisol) were amended with five kinds of biochars at application rate of 0, 1, and 2% (w/w). After 3-month incubation, availability and chemical forms of P were measured to investigate the potential effect and role of biochar in improving P availability in soils...
January 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29327008/an-upconversion-nanoparticle-based-fluorescence-resonance-energy-transfer-system-for-effectively-sensing-caspase-3-activity
#9
Lin Liu, Hua Zhang, Daqian Song, Zhenxin Wang
We report a new fluorescence resonance energy transfer (FRET) sensing platform for the sensitive detection of caspase-3 activity in vitro and in cells using NaGdF4:Yb3+,Er3+@NaGdF4 upconversion nanoparticles (UCNPs) as the energy donor and Rhodamine B (RB) as the energy acceptor. The phosphorylated RB-modified peptide containing a caspase-3 cleavage site and cell-penetrating peptide (CPP) motif (sequence, (RB)-DEVDGGS(p)GCGT(p)GRKKRRQRRRPQ) is immobilized on the UCNP surface via the strong coordination interaction between Gd3+ ions with phosphate...
January 12, 2018: Analyst
https://www.readbyqxmd.com/read/29326006/digestate-application-in-landfill-bioreactors-to-remove-nitrogen-of-old-landfill-leachate
#10
Wei Peng, Alberto Pivato, Maria Cristina Lavagnolo, Roberto Raga
Anaerobic digestion of organics is one of the most used solution to gain renewable energy from waste and the final product, the digestate, still rich in putrescible components and nutrients, is mainly considered for reutilization (in land use) as a bio-fertilizer or a compost after its treatment. Alternative approaches are recommended in situations where conventional digestate management practices are not suitable. Aim of this study was to develop an alternative option to use digestate to enhance nitrified leachate treatment through a digestate layer in a landfill bioreactor...
January 8, 2018: Waste Management
https://www.readbyqxmd.com/read/29325896/gut-flora-dependent-metabolite-trimethylamine-n-oxide-accelerates-endothelial-cell-senescence-and-vascular-aging-through-oxidative-stress
#11
Yilang Ke, Dang Li, Mingming Zhao, Changjie Liu, Jia Liu, Aiping Zeng, Xiaoyun Shi, Si Cheng, Bing Pan, Lemin Zheng, Huashan Hong
Trimethylamine-N-oxide (TMAO), gut microbiota-dependent metabolites, has been shown to be associated with cardiovascular diseases. However, little is known about the relationship between TMAO and vascular aging. Here, we observed a change in TMAO during the aging process and the effects of TMAO on vascular aging and endothelial cell (EC) senescence. We analyzed age-related plasma levels of TMAO in young adults (18-44 years old), older adults (≥65 years old), and 1-month-old, 3-month-old, 6-month-old and 10-month-old senescence-accelerated mouse prone 8 (SAMP8) and age-matched senescence-accelerated mouse resistance 1 (SAMR1) models...
January 8, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29325551/relationship-between-cardiac-microvascular-dysfunction-measured-with-82rubidium-pet-and-albuminuria-in-patients-with-diabetes-mellitus
#12
Louis Potier, Renata Chequer, Ronan Roussel, Kamel Mohammedi, Souad Sismail, Agnès Hartemann, Chloé Amouyal, Michel Marre, Dominique Le Guludec, Fabien Hyafil
BACKGROUND: Albuminuria is of one the strongest predictors of cardiovascular disease (CVD) in diabetes. Diabetes is associated with cardiac microvascular dysfunction (CMD), a powerful, independent prognostic factor for cardiac mortality. The aim of this study was to evaluate the relationship between CMD and microvascular complications in patients without known CVD. METHODS: In this monocentric study, myocardial flow reserve (MFR) was measured with cardiac 82Rubidium positron emission tomography (Rb-PET) in 311 patients referred to nuclear medicine department of Bichat University Hospital for screening of coronary artery disease from 2012 to 2014...
January 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29324346/synthesis-and-biological-characterization-of-novel-rose-bengal-derivatives-with-improved-amphiphilicity-for-sono-photodynamic-therapy
#13
Hai-Jun Chen, Xiao-Bin Zhou, Ai-Lan Wang, Bi-Yuan Zheng, Chih-Kuang Yeh, Jian-Dong Huang
Sono-Photodynamic therapy (SPDT) utilizing ultrasound and light has been demonstrated that this novel approach can lower dosage resulting in reduction of the potential side effects caused by sensitizers. Recently, a new formulation of rose bengal (RB) as an intralesional injection has completed clinical trials phase II for PDT treatment of melanoma cancer. However, the inherent unfavorable pharmacological properties of RB hindered its extensive clinical development. With the aim to identify new RB derivatives (RBDs) with enhanced photodynamic and sonodynamic anticancer efficiency, a series of amphiphilic RBDs have been designed, synthesized and biological characterized...
January 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29322691/raspberry-supplementation-improves-insulin-signaling-and-promotes-brown-like-adipocyte-development-in-white-adipose-tissue-of-obese-mice
#14
Tong Xing, Yifei Kang, Xinglian Xu, Bo Wang, Min Du, Mei-Jun Zhu
SCOPE: Excessive lipid accumulation in white adipose tissue (WAT) leads to chronic inflammation and metabolic dysfunction. Raspberry (RB) contains high amount of polyphenolics and dietary fibers. The objective of the study is to evaluate effects of RB supplementation on WAT morphology, inflammation and insulin signaling in high fat diet (HFD)-induced obese mice, and further explore the underlying mechanisms. METHODS AND RESULTS: C57BL/6J mice were fed with a control diet or a HFD supplemented with 0 or 5% freeze dried RB for 12 weeks...
January 10, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29321667/the-management-of-retinoblastoma
#15
REVIEW
Ido D Fabian, Zerrin Onadim, Esin Karaa, Catriona Duncan, Tanzina Chowdhury, Irene Scheimberg, Shin-Ichi Ohnuma, M Ashwin Reddy, Mandeep S Sagoo
Retinoblastoma (Rb) is the most common primary intraocular malignancy of childhood, but an uncommon paediatric cancer, with a constant incidence worldwide of 1:15,000-1:20,000 live births. Despite its rarity, Rb has served as a cornerstone in the field of oncology in many of the aspects that comprise cancer management, including classification schemes, treatment modalities, genetic testing and screening. Until just over half a century ago, the major treatment for Rb was eye removal, and prognosis was poor with outcome fatal for most children...
January 11, 2018: Oncogene
https://www.readbyqxmd.com/read/29320880/gas-phase-relative-stabilities-of-tl-crown-ether-complexes-and-rb-crown-ether-complexes
#16
Magdalena Frańska, Anna Michalak
The gas-phase stabilities of Tl+-crown ether complexes and Rb+-crown ether complexes were studied using the electrospray ionization-collision-induced dissociation-tandem mass spectrometry. Tl+ and Rb+ have identical ionic radii, thus a comparison of the properties of the crown ether complexes with these two cations seems to be justified. The selected crown ethers were 12C4 (it has a cavity smaller than the cation radius), 18C6 (it has a cavity of size similar to the cation radius), 24C8 (it has a cavity greater than the cation radius) and their conjugates...
January 1, 2018: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29318305/geographical-origin-characterization-of-slovenian-organic-garlic-using-stable-isotope-and-elemental-composition-analyses
#17
Anja Mahne Opatić, Marijan Nečemer, David Kocman, Sonja Lojen
In the present research, the applicability of stable isotope (δ13C, δ15N, δ34S, δ18O) and multi-element (P, S, Cl, K, Ca, Zn, Br, Rb, Sr) data for determining the geographical origin of garlic (Allium sativum L.) at the scale of Slovenia was examined. Slovenia is a rather small country (20273 km2) with significant geological and biological diversity. Garlic, valued for its medicinal properties, was collected from Slovenian farms with certified organic production and analyzed by elemental analyzer isotope ratio mass spectrometry combined with energy dispersive X- ray fluorescence spectrometry...
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29317752/epstein-barr-virus-encoded-rnas-ebers-complement-the-loss-of-herpesvirus-telomerase-rna-vtr-in-virus-induced-tumor-formation
#18
Ahmed Kheimar, Benedikt B Kaufer
Marek's disease virus (MDV) is an alphaherpesvirus that causes fatal lymphomas in chickens and is used as a natural virus-host model for herpesvirus-induced tumorigenesis. MDV encodes a telomerase RNA subunit (vTR) that is crucial for efficient MDV-induced lymphoma formation; however, the mechanism is not completely understood. Similarly, Epstein Barr-virus (EBV) encodes two RNAs (EBER-1 and EBER-2) that are highly expressed in EBV-induced tumor cells, however their role in tumorigenesis remains unclear. Intriguingly, vTR and EBER-1 have interaction partners in common that are highly conserved in humans and chickens...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316132/cation-tuned-synthesis-of-fluorooxoborates-approaching-the-optimal-deep-ultraviolet-nonlinear-optical-materials
#19
Ying Wang, Bingbing Zhang, Zhihua Yang, Shilie Pan
Developing new nonlinear optical (NLO) materials for deep-ultraviolet (DUV) applications is in great demand. However, it is still a serious material discovery challenge to synthesize an ideal DUV NLO crystal. Here, three new alkali metal fluorooxoborates in a family, AB4O6F (A = K, Rb, and Cs, and mixed cation between two of them), were successfully synthesized by cation regulation. It is found that all reported compounds exhibit short UV absorption edges (<190 nm), and show second harmonic generation (SHG) responses ranging from 0...
January 8, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29316109/a-comparative-study-on-the-photophysics-and-photochemistry-of-xanthene-dyes-in-the-presence-of-pamam-dendrimers
#20
Ernesto Arbeloa, Carlos Mario Previtali, Sonia Graciela Bertolotti
The photophysical and photochemical properties of the xanthene dyes Eosin-Y (Eos), Erythrosin-B (Ery) and Rose Bengal (RB) were evaluated in the presence of amino-terminated polyamido-amine (PAMAM) dendrimers of relatively high generations (G3-G5), in alkaline aqueous solution. UV-Vis absorption and fluorescence spectra of the dyes showed bathochromic shifts, which correlated with the size of the dendrimer. From absorption data binding constant (Kbind) were calculated. High Kbind values resulted, indicating a strong interaction between both molecules...
January 7, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
keyword
keyword
62077
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"