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https://www.readbyqxmd.com/read/28212547/resveratrol-induces-cell-cycle-arrest-and-apoptosis-with-docetaxel-in-prostate-cancer-cells-via-a-p53-p21waf1-cip1-and-p27kip1-pathway
#1
Santosh Kumar Singh, Saswati Banerjee, Edward P Acosta, James W Lillard, Rajesh Singh
Resveratrol (RES) is the most effective natural products used for the treatment of a variety of cancers. In this study, we tested the effect of RES in enhancing the efficacy of docetaxel (DTX) treatment in prostate cancer (PCa) cells. The C4-2B and DU-145 cell lines were treated with RES, DTX and combination followed by evaluating the apoptosis and cell cycle progression. The combined drug treatment up-regulates the pro-apoptotic genes (BAX, BID, and BAK), cleaved PARP and down regulates the anti-apoptotic genes (MCL-1, BCL-2, BCL-XL) promoting apoptosis...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28211871/expression-level-is-a-key-determinant-of-e2f1-mediated-cell-fate
#2
Igor Shats, Michael Deng, Adam Davidovich, Carolyn Zhang, Jungeun S Kwon, Dinesh Manandhar, Raluca Gordân, Guang Yao, Lingchong You
The Rb/E2F network has a critical role in regulating cell cycle progression and cell fate decisions. It is dysfunctional in virtually all human cancers, because of genetic lesions that cause overexpression of activators, inactivation of repressors, or both. Paradoxically, the downstream target of this network, E2F1, is rarely strongly overexpressed in cancer. E2F1 can induce both proliferation and apoptosis but the factors governing these critical cell fate decisions remain unclear. Previous studies have focused on qualitative mechanisms such as differential cofactors, posttranslational modification or state of other signaling pathways as modifiers of the cell fate decisions downstream of E2F1 activation...
February 17, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28211617/phosphorylation-of-prb-mechanism-for-rb-pathway-inactivation-in-mycn-amplified-retinoblastoma
#3
Kathryn G Ewens, Tricia R Bhatti, Kimberly A Moran, Jennifer Richards-Yutz, Carol L Shields, Ralph C Eagle, Arupa Ganguly
A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification. This manuscript investigated alternate pathways of inactivating pRb, the encoded protein in these tumors. We analyzed the mutation status of the RB1 gene and MYCN copy number in a series of 245 unilateral retinoblastomas, and the phosphorylation status of pRb in a subset of five tumors using immunohistochemistry. There were 203 tumors with two mutations in RB1 (RB1(-/-) , 83%), 29 with one (RB1(+/-) , 12%) and 13 with no detectable mutations (RB1(+/+) , 5%)...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28210099/study-of-polymorphisms-in-the-tp53-and-rb1-genes-in-children-with-retinoblastoma-in-northern-mexico
#4
Edwin J Anaya-Pava, Jesús Nares-Cisneros, Rubén I Cárdenas-Hernández, Yolanda Jaramillo-Rodríguez, Graciela Zambrano-Galván
PURPOSE: To determine the frequency and association of polymorphisms in the TP53 and RB1 genes with clinical characteristics in a group of children with retinoblastoma (RB) in northern Mexico. METHODS: A prospective, longitudinal, and analytical study of 11 patients diagnosed with RB was conducted. Endpoint PCR and high-resolution real-time PCR were performed. Chi-square and Student t tests were used to evaluate associations between variables. Allelic frequencies, as well as genotypic and Hardy-Weinberg equilibriums, were evaluated using Guo and Thompson's method...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28206752/columnar-self-assemblies-of-triarylamines-as-scaffolds-for-artificial-biomimetic-channels-for-ion-and-for-water-transport
#5
Susanne Schneider, Erol-Dan Licsandru, Istvan Kocsis, Arnaud Gilles, Florina Dumitru, Emilie Moulin, Junjun Tan, Jean-Marie Lehn, Nicolas Giuseppone, Mihail Barboiu
Triarylamine molecules appended with crown-ethers or carboxylic moieties form self-assembled supramolecular channels within lipid bilayers. Fluorescence assays and voltage clamp studies reveal that the self-assemblies incorporating the crown ethers work as single channels for the selective transport of K+ or Rb+. The X-ray crystallographic structures confirm the mutual columnar self-assembly of triarylamines and crown-ethers. The dimensional fit of K+ cations within the 18-crown-6, leads to a partial dehydration and to the formation of alternating K+ cation-water wires within the channel...
February 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28205113/cardiac-pet-ct-with-rb-82-optimization-of-image-acquisition-and-reconstruction-parameters
#6
P Chilra, S Gnesin, G Allenbach, M Monteiro, J O Prior, L Vieira, J A Pires Jorge
BACKGROUND: Our aim was to characterize the influence of time-of-flight (TOF) and point spread function (PSF) recovery corrections, as well as ordered subset expectation maximization (OSEM) reconstruction parameters, in (82)Rb PET/CT quantification of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Rest and stress list-mode dynamic (82)Rb PET acquisition data from 10 patients without myocardial flow defects and 10 patients with myocardial blood flow defects were reconstructed retrospectively...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28203658/ionic-conductivity-and-mixed-ion-effect-in-mixed-alkali-metaphosphate-glasses
#7
Jefferson Esquina Tsuchida, Fabio Aparecido Ferri, Paulo Sergio Pizani, Ana Candida Martins Rodrigues, Swarup Kundu, José Fabián Schneider, Edgar Dutra Zanotto
In this work, mixed alkali metaphosphate glasses based on K-Na, Rb-Na, Rb-Li, Cs-Na and Cs-Li combinations were studied by differential scanning calorimetry (DSC), complex impedance spectroscopy, and Raman spectroscopy. DSC analyses show that both the glass transition (Tg) and melting temperatures (Tm) exhibit a clear mixed-ion effect. The ionic conductivity shows a strong mixed-ion effect and decreases by more than six orders of magnitude at room temperature for Rb-Na or Cs-Li alkali pairs. This study confirms that the mixed-ion effect may be explained as a natural consequence of random ion mixing because ion transport is favoured between well-matched energy sites and is impeded due to the structural mismatch between neighbouring sites for dissimilar ions...
February 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28203301/progress-with-palbociclib-in-breast-cancer-latest-evidence-and-clinical-considerations
#8
REVIEW
Andrea Rocca, Alessio Schirone, Roberta Maltoni, Sara Bravaccini, Lorenzo Cecconetto, Alberto Farolfi, Giuseppe Bronte, Daniele Andreis
Deregulation of the cell cycle is a hallmark of cancer, and research on cell cycle control has allowed identification of potential targets for anticancer treatment. Palbociclib is a selective inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6), which are involved, with their coregulatory partners cyclin D, in the G1-S transition. Inhibition of this step halts cell cycle progression in cells in which the involved pathway, including the retinoblastoma protein (Rb) and the E2F family of transcription factors, is functioning, although having been deregulated...
February 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/28203076/light-triggered-liposomal-cargo-delivery-platform-incorporating-photosensitizers-and-gold-nanoparticles-for-enhanced-singlet-oxygen-generation-and-increased-cytotoxicity
#9
Zofia Kautzka, Sandhya Clement, Ewa M Goldys, Wei Deng
We developed light-triggered liposomes incorporating 3-5 nm hydrophobic gold nanoparticles and Rose Bengal (RB), a well-known photosensitizer used for photodynamic therapy. Singlet oxygen generated by these liposomes with 532 nm light illumination was characterized for varying the molar ratio of lipids and gold nanoparticles while keeping the amount of RB constant. Gold nanoparticles were found to enhance the singlet oxygen generation rate, with a maximum enhancement factor of 1.75 obtained for the molar ratio of hydrogenated soy l-α-phosphatidylcholine:1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(hexanoylamine):gold of 57:5:17 compared with liposomes loaded with RB alone...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28198835/methane-based-in-situ-temperature-rise-measurement-in-a-diode-pumped-rubidium-laser
#10
Rui Wang, Zining Yang, Hongyan Wang, Xiaojun Xu
We measured active zone temperature rise of an operational diode-pumped rubidium laser non-perturbatively with methane-based near-infrared tunable diode laser spectroscopy (TDLAS). For a Rb+ methane diode-pumped alkali laser (DPAL), the temperature rise was obtained. Especially, the temperature differences (∼10  K) between lasing and un-lasing cases were well identified, which demonstrated a high sensitivity of the method. To our knowledge, this is the first demonstration of extending the methane-based TDLAS method to DPAL study...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28197612/crystal-structure-and-spin-trimer-magnetism-of-rb2-3-h2o-0-8mn3-b4p6o24-o-oh-2
#11
Olga V Yakubovich, Larisa V Shvanskaya, Galina V Kiriukhina, Anatoly S Volkov, Olga V Dimitrova, Evgeny A Ovchenkov, Alexander A Tsirlin, Alexander A Shakin, Olga S Volkova, Alexander N Vasiliev
The novel borophosphate Rb2.3(H2O)0.8Mn3[B4P6O24(O,OH)2] was prepared under hydrothermal conditions at 553 K. Its crystal structure was determined using single-crystal X-ray diffraction data obtained from a non-merohedral twin and refined against F(2) to R = 0.057. The compound crystallizes in the orthorhombic space group Pbcn, with unit-cell parameters a = 20.076(2) Å, b = 9.151(1) Å, c = 12.257(1) Å, V = 2251.8(2) Å(3), and Z = 4. The title compound is the first example of a borophosphate with manganese ions adopting both octahedral and tetrahedral coordinations...
February 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28197540/an-rb-insensitive-to-cdk-regulation
#12
Manel Joaquin, Eulàlia de Nadal, Francesc Posas
The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays tumor cell growth. This novel mechanism of RB regulation opens up a window for developing new cancer drug treatments for tumors harboring high CDK-Cyclin activity and a wild-type RB gene.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28194440/transient-antibody-targeting-of-cd45rc-induces-transplant-tolerance-and-potent-antigen-specific-regulatory-t-cells
#13
Elodie Picarda, Séverine Bézie, Laetitia Boucault, Elodie Autrusseau, Stéphanie Kilens, Dimitri Meistermann, Bernard Martinet, Véronique Daguin, Audrey Donnart, Eric Charpentier, Laurent David, Ignacio Anegon, Carole Guillonneau
Rat and human CD4(+) and CD8(+) Tregs expressing low levels of CD45RC have strong immunoregulatory properties. We describe here that human CD45 isoforms are nonredundant and identify distinct subsets of cells. We show that CD45RC is not expressed by CD4(+) and CD8(+) Foxp3(+) Tregs, while CD45RA/RB/RO are. Transient administration of a monoclonal antibody (mAb) targeting CD45RC in a rat cardiac allotransplantation model induced transplant tolerance associated with inhibition of allogeneic humoral responses but maintained primary and memory responses against cognate antigens...
February 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28193182/de-novo-mutational-profile-in-rb1-clarified-using-a-mutation-rate-modeling-algorithm
#14
Varun Aggarwala, Arupa Ganguly, Benjamin F Voight
BACKGROUND: Studies of de novo mutations offer great promise to improve our understanding of human disease. After a causal gene has been identified, it is natural to hypothesize that disease relevant mutations accumulate within a sub-sequence of the gene - for example, an exon, a protein domain, or at CpG sites. These assessments are typically qualitative, because we lack methodology to assess the statistical significance of sub-gene mutational burden ultimately to infer disease-relevant biology...
February 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28192957/integrated-extraction-chromatographic-separation-of-the-lithophile-elements-involved-in-long-lived-radiogenic-isotope-systems-rb-sr-u-th-pb-sm-nd-la-ce-and-lu-hf-useful-in-geochemical-and-environmental-sciences
#15
Christian Pin, Abdelmouhcine Gannoun
A fast and efficient sample preparation method in view of isotope ratio measurements is described, allowing the separation of 11 elements involved, either as "parent" or as "daughter" isotopes, in six radiogenic isotope systems used as chronometers and tracers in earth, planetary, and environmental sciences. The protocol is based on small extraction chromatographic columns, used either alone or in tandem, through which a single nitric acid solution is passed, without any intervening evaporation step. The columns use commercially available extraction resins (Sr resin, TRU resin, Ln resin, RE resin, and again Ln resin for isolating Sr and Pb, LREE then La-Ce-Nd-Sm, Lu(Yb), and Hf, Th, and U, respectively) along with an additional, in-house prepared resin for separating Rb...
February 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191765/generation-of-osteosarcomas-from-a-combination-of-rb-silencing-and-c-myc-overexpression-in-human-mesenchymal-stem-cells
#16
Jir-You Wang, Po-Kuei Wu, Paul Chih-Hsueh Chen, Chia-Wen Lee, Wei-Ming Chen, Shih-Chieh Hung
Osteosarcoma (OS) was a malignant tumor occurring with unknown etiology that made prevention and early diagnosis difficult. Mesenchymal stem cells (MSCs), which were found in bone marrow, were claimed to be a possible origin of OS but with little direct evidence. We aimed to characterize OS cells transformed from human MSCs (hMSCs) and identify their association with human primary OS cells and patient survival. Genetic modification with p53 or retinoblastoma (Rb) knockdown and c-Myc or Ras overexpression was applied for hMSC transformation...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28191638/enhancement-of-the-efficacy-of-photodynamic-inactivation-of-candida-albicans-with-the-use-of-biogenic-gold-nanoparticles
#17
Irena Maliszewska, Barbara Lisiak, Katarzyna Popko, Katarzyna Matczyszyn
This study reports on successful photodynamic inactivation of planktonic and biofilm cells of Candida albicans using Rose Bengal (RB) in combination with biogenic gold nanoparticles synthesized by the cell-free filtrate of Penicillium funiculosum BL1 strain. Monodispersed colloidal gold nanoparticles coated with proteins were characterized by a number of techniques including SEM-EDS, TEM, UV-Vis absorption and fluorescence spectroscopy, as well as Fourier transform infrared spectroscopy to be 24±3 nm spheres coated with proteins...
February 12, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28184924/mir-922-regulates-cyld-expression-and-promotes-the-cell-proliferation-of-human-hepatocellular-carcinoma
#18
Jianping Liu, Zheng Su, Yunjie Zeng, Huayao Zhang, Shanglin Yang, Gaojie Liu
Evidence reveals that microRNAs (miRNAs) play essential roles in hepatocellular carcinoma (HCC) tumorigenesis. In the present study, we identified an essential role for miR-922 in the development of HCC. We found that miR-922 was significantly upregulated in HCC cells and clinical tissues. Gain and loss of function studies indicated that miR-922 significantly promoted HCC cell proliferation. We subsequently identified that cylindromatosis (CYLD) was a target gene of miR-922. Moreover, miR-922 decreased CYLD expression, subsequently upregulating the expression of c-Myc and cyclin D1, while downregulating p-Rb expression...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28181135/survival-of-lung-cancer-patients-is-prolonged-with-higher-regucalcin-gene-expression-suppressed-proliferation-of-lung-adenocarcinoma-a549-cells-in-vitro
#19
Masayoshi Yamaguchi, Satoru Osuka, Mamoru Shoji, M Neale Weitzmann, Tomiyasu Murata
Regucalcin plays a crucial role as a suppressor of transcription signaling, and its diminished expression or activity may play a key role in human carcinogenesis. Higher regucalcin expression has been demonstrated to prolong survival of the patients of pancreatic cancer, breast cancer, and hepatocellular carcinoma. Moreover, we investigated an involvement of regucalcin in human lung cancer. Human non-small cell lung cancer (NSCLC) accounts for over 80% in human lung cancer and is one of the leading causes of malignancy-related mortality with fewer than 16% patients surviving beyond 5 years...
February 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28179522/landscape-context-alters-cost-of-living-in-honeybee-metabolism-and-feeding
#20
Sean Tomlinson, Kingsley W Dixon, Raphael K Didham, S Donald Bradshaw
Field metabolic rate (FMR) links the energy budget of an animal with the constraints of its ecosystem, but is particularly difficult to measure for small organisms. Landscape degradation exacerbates environmental adversity and reduces resource availability, imposing higher costs of living for many organisms. Here, we report a significant effect of landscape degradation on the FMR of free-flying Apis mellifera, estimated using (86)Rb radio-isotopic turnover. We validated the relationship between (86)Rb kb and metabolic rate for worker bees in the laboratory using flow-through respirometry...
February 8, 2017: Proceedings. Biological Sciences
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