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https://www.readbyqxmd.com/read/28636233/green-synthesis-of-small-nanoparticles-of-a2sif6-a-li-cs-using-ionic-liquids-as-solvent-and-fluorine-source-a-novel-simple-approach-without-hf
#1
Jacob Olchowka, Markus Suta, Claudia Wickleder
In this communication, nanoparticles of the fluoridosilicates A2SiF6 (A= Li, Na, K, Rb, Cs), which are extremely promising host lattices for future LEDs, are presented for the first time. The preparation method we introduces here is a very simple and energy and time saving one, moreover the usage of toxic HF or elemental fluorine is avoided. In detail, the ionic liquid [Bmim]PF6 was used both as solvent and fluoride source in an ionothermally assisted microwave synthesis. The small size of the so obtained nanoparticles is of huge relevance for their applications as thin films or coverage of surfaces for, e...
June 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28636114/set-i2pp2a-overexpression-induces-phenotypic-molecular-and-metabolic-alterations-in-an-oral-keratinocyte-cell-line
#2
Lays M Sobral, Ricardo D Coletta, Luciane C Alberici, Carlos Curti, Andréia Machado Leopoldino
The multifunctional SET/I2PP2A protein is known to be overexpressed in head and neck squamous cell carcinoma. However, SET has been reported to have apparently conflicting roles in promoting cancer cell survival under oxidative stress conditions and preventing invasion and metastasis, complicating efforts to understand the contribution of SET to carcinogenesis. In the present study, we overexpressed SET in a spontaneously immortalized oral keratinocyte cell line (NOK-SI SET) and demonstrated that SET up-regulation alone was sufficient to transform cells...
June 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28633655/inhibition-of-mmp-2-and-mmp-9-decreases-cellular-migration-and-angiogenesis-in-in-vitro-models-of-retinoblastoma
#3
Anderson H Webb, Bradley T Gao, Zachary K Goldsmith, Andrew S Irvine, Nabil Saleh, Ryan P Lee, Justin B Lendermon, Rajini Bheemreddy, Qiuhua Zhang, Rachel C Brennan, Dianna Johnson, Jena J Steinle, Matthew W Wilson, Vanessa M Morales-Tirado
BACKGROUND: Retinoblastoma (Rb) is the most common primary intraocular tumor in children. Local treatment of the intraocular disease is usually effective if diagnosed early; however advanced Rb can metastasize through routes that involve invasion of the choroid, sclera and optic nerve or more broadly via the ocular vasculature. Metastatic Rb patients have very high mortality rates. While current therapy for Rb is directed toward blocking tumor cell division and tumor growth, there are no specific treatments targeted to block Rb metastasis...
June 20, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28631860/abi2-io3-2f5-a-k-rb-and-cs-combination-of-halide-and-oxide-anionic-units-to-create-large-shg-response-with-wide-bandgap
#4
Xingguo Chen, Hongming Liu, Qi Wu, Xingxing Jiang, Xianggao Meng, Zheshuai Lin, Jingui Qin
A family of nonlinear optical materials that contain the halide, oxide and oxyhalide polar units simultaneously in a single structure, namely, ABi2(IO3)2F5 (A = K, 1;Rb,2 and Cs,3), have been designed and synthesized. They crystallize in the same polar space group of P21 with a two-dimensional double-layered framework constructed by [BiF5]2- and [BiO2F4]5- units connected to each other by four F atoms, in which two [IO3]- groups are linked to [BiO2F4]5- unit on the same side, and a hanging Bi-F bond of [BiF5]2- unit is located on the other side via ionic interaction with the layer-inserted alkali metal ions to form three-dimensional structure...
June 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28631603/a-single-point-mutation-in-tomato-spotted-wilt-virus-nss-protein-is-sufficient-to-overcome-tsw-gene-mediated-resistance-in-pepper
#5
Asztéria Almási, Katalin Nemes, Zsófia Csömör, István Tóbiás, László Palkovics, Katalin Salánki
The nonstructural protein (NSs) of Tomato spotted wilt virus (TSWV) was previously identified as an avirulence determinant for Tsw-based resistance on pepper. The NSs of wild-type (WT) and resistance-breaking (RB) TSWV strains isolated in Hungary had only two amino acid substitutions (104, 461). We have analysed the ability of the NSs and their point mutant variants to trigger Tsw-mediated hypersensitive responses and RNA silencing suppressor (RSS) activity in patch assays. We identified a single amino acid change at position 104 (T-A) that was responsible for the necrosis induction or loss, while a significant difference was not detected in the RSS activity of the two parental strains...
June 20, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28630784/elemental-characterization-of-romanian-crop-medicinal-plants-by-neutron-activation-analysis
#6
Daniela Haidu, Dénes Párkányi, Radu Ioan Moldovan, Cecilia Savii, Iulia Pinzaru, Cristina Dehelean, Ludovic Kurunczi
The metallic elements concentrations of medicinal plants (coriander, dill, Echinacea, lavender, chamomile, mint, and plantain, used for phytopharmaceutical products), cultivated in unpolluted region, were analyzed by neutron activation analysis. The essential nutrients, macro-, micro-, and trace elements (K, Ca, Mg, Na, Fe, Mn, Rb, Sr, and Zn), potentially toxic elements (Al, As, Ba, Co, Sb, Cr, and V), and rare earth elements were monitored and were compared with those presented in the literature. An estimation of their contributions to intake and toxicity for a person was made, which revealed that (a) teas prepared from the examined plants represent useful contribution to the food provided intake of three essential macronutrients (K, Ca, and Mg); (b) the Cu, Mn, Rb, Sr, Zn, and rare earths levels are normal or low; (c) the quantities of As, Ba, Co, Sb, Cr, and V do not represent toxicological concerns; (d) the examination of the estimated Al and Fe quantities recovered in infusions in the conditions of usual daily tea consumption is below the Tolerable Daily Intake values...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28630280/ki-67-contributes-to-normal-cell-cycle-progression-and-inactive-x-heterochromatin-in-p21-checkpoint-proficient-human-cells
#7
Xiaoming Sun, Aizhan Bizhanova, Timothy D Matheson, Jun Yu, Julie L Zhu, Paul D Kaufman
Ki-67 protein is widely used as a tumor proliferation marker. However, whether Ki-67 affects cell cycle progression has been controversial. Here, we demonstrate that depletion of Ki-67 in human hTERT-RPE1, WI-38, IMR90, hTERT-BJ cell lines and primary fibroblast cells slowed entry into S phase and coordinately downregulated genes related to DNA replication. Some gene expression changes were partially relieved in Ki-67-depleted hTERT-RPE1 cells by co-depletion of the Rb checkpoint protein, but more thorough suppression of the transcriptional and cell cycle defects was observed upon depletion of cell cycle inhibitor p21...
June 19, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28629793/the-effects-of-hypoxia-on-active-ionic-transport-processes-in-the-gill-epithelium-of-hyperregulating-crab-carcinus-maneas
#8
Čedomil Lucu, Andreas Ziegler
Effects of hypoxia on the osmorespiratory functions of the posterior gills of the shore crab Carcinus maenas acclimated to 12ppt seawater (DSW) were studied. Short-circuit current (Isc) across the hemilamella (one epithelium layer supported by cuticle) was substantially reduced under exposure to 1.6, 2.0, or 2.5mg O2/L hypoxic saline (both sides of epithelium) and fully recovered after reoxygenation. Isc was reduced equally in the epithelium exposed to 1.6mg O2/L on both sides and when the apical side was oxygenated and the basolateral side solely exposed to hypoxia...
June 16, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28628830/breviscapine-bvp-inhibits-prostate-cancer-progression-through-damaging-dna-by-minichromosome-maintenance-protein-7-mcm-7-modulation
#9
Yang-Bo Guan, Dong-Rong Yang, Shao-Jun Nong, Jian Ni, Chun-Hui Hu, Jian Li, Jin Zhu, Yu-Xi Shan
Naturally occurring compounds are reported as effective candidates for prevention and treatment of various cancers. Breviscapine (BVP) is a mixture of flavonoid glycosides, derived from the Chinese herbs. Previous researches have indicated that BVP has comprehensive pharmacological functions. However, little is known about whether BVP has preventive effects on human prostate cancer. Here, we attempted to explore if BVP inhibits human prostate cancer in vitro and in vivo in a comprehensive manner. We found that BVP triggered cytotoxicity in prostate cancer cell lines dose-dependently...
June 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28627715/transition-and-alkali-metal-complex-ternary-amides-for-ammonia-synthesis-and-decomposition
#10
Hujun Cao, Jianping Guo, Fei Chang, Claudio Pistidda, Wei Zhou, Xilun Zhang, Antonio Santoru, Hui Wu, Norbert Schnell, Rainer Niewa, Ping Chen, Thomas Klassen, Martin Dornheim
A new complex ternary amide Rb2[Mn(NH2)4], which contains both transition and alkali metal catalytic sites, is synthesized by mechanochemical reaction. It exhibits two temperature-dependent polymorphs i.e. low-temperature orthorhombic and high-temperature monoclinic structures. Rb2[Mn(NH2)4] decomposes to N2, H2, NH3, Mn3N2, and RbNH2 under inert atmosphere; whereas releases NH3 at 80 °C under H2 atmosphere. Those unique behaviors enable Rb2[Mn(NH2)4] and K2[Mn(NH2)4] as excellent materials for NH3 decomposition and synthesis...
June 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28627689/expression-of-cell-cycle-related-proteins-in-oropharyngeal-squamous-cell-carcinoma-based-on-human-papilloma-virus-status
#11
Koudai Tsuchida, Tamotsu Sugai, Noriyuki Uesugi, Kazuyuki Ishida, Kazuto Matsuura, Ikuro Sato, Kiyoto Shiga, Hiroaki Sato
The molecular association between human papilloma virus (HPV) and cell cycle-related (CCR) proteins is not fully understood in oropharyngeal squamous cell carcinoma (OPSCC). Herein, we examined the expression levels of CCRs in OPSCCs based on HPV status. In situ hybridization (ISH)- and polymerase chain reaction (PCR)-based assays were used to detect HPV status in 98 OPSCCs, and CCRs were detected by immunostaining. Of 98 tumors, 47 had HPV-positive tumors by either ISH- or PCR-based assays. Concordance analysis between ISH- and PCR-based tests showed a good agreement in OPSCC...
June 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28627594/microrna-320-inhibits-cell-proliferation-migration-and-invasion-in-retinoblastoma-by-targeting-specificity-protein-1
#12
Yuehua Zhao, Shilian Zhang, Yongfeng Zhang
Research into the expression and function of microRNAs (miRNAs/miR) in human cancer has provided novel insights into the molecular mechanisms underlying carcinogenesis and cancer progression. Aberrant miRNA expression has been reported in retinoblastoma (RB) and several other types of human cancer. The present study demonstrated that miR‑320 is significantly downregulated in RB tissues and cell lines. Furthermore, overexpression of miR‑320 was demonstrated to inhibit proliferation, migration and invasion of RB cells...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627173/ternary-gold-hydrides-routes-to-stable-and-potentially-superconducting-compounds
#13
Martin Rahm, Roald Hoffmann, N W Ashcroft
In a search for gold hydrides, an initial discouraging result of no theoretical stability in any binary AuHn at P < 300 GPa was overcome by introducing alkali atoms as reductants. A set of AAuH2 compounds, A = Li, Na, K, Rb, and Cs, is examined; of these, certain K, Rb, and Cs compounds are predicted to be thermodynamically stable. All contain AuH2(-) molecular units and are semiconducting at P = 1 atm, and some form metallic and superconducting symmetrically bonded AuHAu sheets under compression. To induce metallicity by bringing the Au atoms closer together under ambient conditions, we examined alkaline earth ion substitution for two A, i...
June 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28626456/bactericidal-effect-of-photodynamic-therapy-alone-or-in-combination-with-mupirocin-or-linezolid-on-staphylococcus-aureus
#14
Vanesa Pérez-Laguna, Luna Pérez-Artiaga, Verónica Lampaya-Pérez, Isabel García-Luque, Sofía Ballesta, Santi Nonell, Manuel P Paz-Cristobal, Yolanda Gilaberte, Antonio Rezusta
Antibiotic treatments frequently fail due to the development of antibiotic resistance, underscoring the need for new treatment strategies. Antimicrobial photodynamic therapy (aPDT) could constitute an alternative therapy. In bacterial suspensions of Staphylococcus aureus, which is commonly implicated in cutaneous and mucosal infections, we evaluated the in vitro efficacy of aPDT, using the photosensitizing agents rose bengal (RB) or methylene blue (MB), alone or combined with the antibiotics mupirocin (MU) or linezolid (LN)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28622869/brucella-lipopolysaccharide-reinforced-salmonella-delivering-brucella-immunogens-protects-mice-against-virulent-challenge
#15
Jonathan Lalsiamthara, John Hwa Lee
Intracellular pathogen Salmonella exhibits natural infection broadly analogous to Brucella, this phenomenon makes Salmonella a pragmatic choice for an anti-Brucella vaccine delivery platform. In this study we developed and formulated a combination of four attenuated Salmonella Typhimurium live vector strains delivering heterologous Brucella antigens (rBs), namely lumazine synthase, proline racemase subunit A, lipoprotein outer membrane protein-19, and Cu-Zn superoxide dismutase. With an aim to develop a cross-protecting vaccine, Brucella pan-species conserved rBs were selected...
June 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28620392/interleukin-25-produced-by-synoviocytes-has-anti-inflammatory-effects-by-acting-as-a-receptor-antagonist-for-interleukin-17a-function
#16
Fabien Lavocat, Ndiémé Ndongo-Thiam, Pierre Miossec
The production and function of cytokines are highly regulated. One mechanism is the balance between pro- and anti-inflammatory cytokines. As interleukin (IL)-17A and IL-25 share the IL-17RA receptor chain, we hypothesize that IL-25 acts as an IL-17A receptor antagonist and limits its pro-inflammatory effects. The production and expression kinetics of IL-25 and its receptor chains IL-17RA and RB were analyzed in rheumatoid synoviocytes alone or in coculture with peripheral blood mononuclear cells (PBMCs). The effects of autocrine or exogenous IL-25 on synoviocytes were investigated in the presence or not of an anti-IL-25 antibody...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28620137/biological-specificity-of-cdk4-6-inhibitors-dose-response-relationship-in-vivo-signaling-and-composite-response-signature
#17
Erik S Knudsen, Jack Hutcheson, Paris Vail, Agnieszka K Witkiewicz
Recently developed potent and selective CDK4/6 inhibitors fall into two classes based on structure and toxicity profiles in clinical studies. One class, exemplified by palbociclib and ribociclib, exhibits neutropenia as a dose-limiting toxicity and requires discontinuous dosing. In contrast, the structurally distinct CDK4/6 inhibitor abemaciclib is dosed continuously, and has diarrhea and fatigue as dose-limiting toxicities. In preclinical models, palbociclib has been extensively studied and induces cell cycle inhibition in an RB-dependent manner...
June 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619757/cdk4-6-inhibitors-sensitize-rb-positive-sarcoma-cells-to-wee1-kinase-inhibition-through-reversible-cell-cycle-arrest
#18
Ashleigh M Francis, Angela Alexander, Yanna Liu, Smruthi Vijayaraghavan, Kwang Hui Low, Dong Yang, Tuyen Bui, Neeta Somaiah, Vinod Ravi, Khandan Keyomarsi, Kelly K Hunt
Research into the biology of soft tissue sarcomas has uncovered very few effective treatment strategies that improve upon the current standard of care which usually involves surgery, radiation, and chemotherapy. Many patients with large (>5cm), high-grade sarcomas develop recurrence, and at that point have limited treatment options available. One challenge is the heterogeneity of genetic drivers of sarcomas, and many of these are not validated targets. Even when such genes are tractable targets, the rarity of each subtype of sarcoma makes advances in research slow...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28619736/effects-of-hypercapnia-on-myocardial-blood-flow-in-healthy-human-subjects
#19
Matthieu Pelletier-Galarneau, Robert A deKemp, Chad Rrn Hunter, Ran Klein, Michael Klein, Joel Ironstone, Joseph A Fisher, Terrence Ruddy
Background: Elevation of end-tidal partial pressure of CO2 (PETCO2) increases cerebral and myocardial blood flow (MBF), suggesting that it may be a suitable alternative to pharmacological stress or exercise for myocardial perfusion imaging. The purpose of this study was to document the pharmacodynamics of CO2 on MBF using prospective end-tidal targeting to precisely control arterial PCO2 and use positron emission tomography (PET) to measure the outcome variable, MBF Methods: 10 healthy males underwent serial (82)Rb PET/CT imaging...
June 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28618524/experimental-velocity-study-of-non-boussinesq-rayleigh-b%C3%A3-nard-convection
#20
Valentina Valori, Gerrit Elsinga, Martin Rohde, Mark Tummers, Jerry Westerweel, Tim van der Hagen
The effects of strongly varying fluid properties, beyond the validity range of the so-called Boussinesq approximation, were experimentally studied in Rayleigh-Bénard (RB) convection. Two experiments were conducted in the same cubical RB convection cell at similar Rayleigh and Prandtl numbers. In one experiment water was used as working fluid and the imposed temperature difference between the top and bottom plates of the cell was such to ensure non-Boussinesq conditions. In the other experiment, taken as a reference for Boussinesq conditions, methanol was used as working fluid, allowing a smaller temperature difference between the plates...
May 2017: Physical Review. E
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