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https://www.readbyqxmd.com/read/28109942/effect-of-pulmonary-rehabilitation-on-tidal-expiratory-flow-limitation-at-rest-and-during-exercise-in-copd-patients
#1
Elpida P Theodorakopoulou, Sofia-Antiopi Gennimata, Maria Harikiopoulou, Georgios Kaltsakas, Anastasios Palamidas, Antonia Koutsoukou, Charis Roussos, Epameinondas N Kosmas, Petros Bakakos, Nickolaos G Koulouris
We hypothesized that severe COPD patients who present with the disadvantageous phenomenon of Expiratory Flow Limitation (EFL) may benefit as COPD patients without EFL do after implementation of a PR program. Forty-two stable COPD patients were studied at rest and during exercise. EFL and dynamic hyperinflation (DH) were documented using the negative expiratory pressure (NEP) technique and inspiratory capacity (IC) maneuvers, respectively. Patient centered outcomes were evaluated by the Saint-George's Respiratory Questionnaire (SGRQ) and the mMRC dyspnea scale...
January 18, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28099960/prognostic-factors-after-curative-resection-for-single-lesion-hepatocellular-carcinoma-in-patients-with-normal-liver-function-a-historical-cohort-study
#2
Mitsugi Shimoda, Kazuma Tago, Masato Kato, Taku Aoki, Keiichi Kubota
BACKGROUND: Hepatic resection for hepatocellular carcinoma (HCC) is now established as the treatment most likely to yield the best outcome. We aimed to clarify the risk factors for HCC recurrence after curative resection of single HCC in patients with normal liver function (NLF). METHODS: The clinical records of 105 patients with NFL and a single HCC less than 5 cm in diameter who had undergone curative liver resection between April 2000 and January 2013 were investigated...
January 19, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28095549/treatment-of-facial-photodamage-with-mass-market-topical-products-vs-non-ablative-fractional-laser
#3
Hilary Reich, Irmina Wallander, Lacie Schulte, Molly Goodier, Brian Zelickson
METHODS: In this split-face, evaluator-blinded study, 18 subjects were randomly assigned to receive either the SSR or NFL treatments on each side of the face. For the SSR facial sides subjects followed two morning-evening regimens. On the NFL sides subjects were treated 3 times with the 1927-nm laser at 4-week intervals. Three physician evaluators were asked to rate hyperpigmentation, global photoaging, and ne lines and wrinkles for each side of the face at baseline and at 3 months using a 5-point scale...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095082/effect-of-concussion-on-performance-of-national-football-league-players
#4
Nicole Reams, Rodney A Hayward, Jeffrey S Kutcher, James F Burke
PURPOSE: Lingering neurologic injury after concussion may expose athletes to increased risk if return-to-play is premature. We explored whether on-field performance after concussion is a marker of lingering neurologic injury. METHODS: Retrospective cohort study on 1,882 skill-position players who played in the National Football League (NFL) during 2007-2010. Players with concussion based on the weekly injury report, were compared to players with other head and neck injuries (controls) on measures of on-field performance using Football Outsiders' calculation of Defense-Adjusted Yards Above Replacement (DYAR): a measure of a player's contribution controlling for game context...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28056179/descriptive-characteristics-of-concussions-in-national-football-league-games-2010-2011-to-2013-2014
#5
Michael D Clark, Breton M Asken, Stephen W Marshall, Kevin M Guskiewicz
BACKGROUND: Despite a high reported incidence rate of concussion, little is known about the on-field characteristics of injurious head impacts in National Football League (NFL) games. PURPOSE: To characterize on-field features (location, player position, and time during game) and biomechanical features (anticipation status, closing distance, impact location and type) associated with concussions in NFL games over a 4-season period (2010-2011 to 2013-2014). STUDY DESIGN: Descriptive epidemiology study...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28052052/physical-characteristics-and-performance-of-japanese-top-level-american-football-players
#6
Daichi Yamashita, Masaki Asakura, Yoshihiko Ito, Shinzo Yamada, Yosuke Yamada
This study aimed to compare the physical characteristics and performance between top-level non-professional football players in Japan and National Football League (NFL) Combine invited players and between top- and middle-level players in Japan in order to determine the factors that enhance performance in international and national competitions. One hundred sixty-eight American football players (>20 years) in Japan participated in an anthropometric (height and weight) and physical (vertical jump, long jump, 40-yard dash, pro-agility shuttle, three-cone drill, and bench press repetition test) measurement program based on the NFL Combine program to compete in the selection of candidates for the Senior World Championship...
November 5, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28046096/early-antiretroviral-therapy-is-associated-with-lower-hiv-dna-molecular-diversity-and-lower-inflammation-in-cerebrospinal-fluid-but-does-not-prevent-the-establishment-of-compartmentalized-hiv-dna-populations
#7
Michelli F Oliveira, Antoine Chaillon, Masato Nakazawa, Milenka Vargas, Scott L Letendre, Matthew C Strain, Ronald J Ellis, Sheldon Morris, Susan J Little, Davey M Smith, Sara Gianella
Even when antiretroviral therapy (ART) is started early after infection, HIV DNA might persist in the central nervous system (CNS), possibly contributing to inflammation, brain damage and neurocognitive impairment. Paired blood and cerebrospinal fluid (CSF) were collected from 16 HIV-infected individuals on suppressive ART: 9 participants started ART <4 months of the estimated date of infection (EDI) ("early ART"), and 7 participants started ART >14 months after EDI ("late ART"). For each participant, neurocognitive functioning was measured by Global Deficit Score (GDS)...
January 3, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28032805/nerve-fiber-layer-thickness-and-characteristics-associated-with-glaucoma-in-community-living-older-adults-prelude-to-a-screening-trial
#8
Barbara E K Klein, Chris A Johnson, Stacy M Meuer, Kyungmoo Lee, Andreas Wahle, Kristine E Lee, Amruta Kulkarni, Milan Sonka, Michael D Abràmoff, Ronald Klein
PURPOSE: To examine the associations of nerve fiber layer (NFL) thickness with other ocular characteristics in older adults. METHODS: Participants in the Beaver Dam Eye Study (2008-2010) underwent spectral domain optical coherence tomography (SD-OCT) scans of the optic nerve head, imaging of optic discs, frequency doubling technology (FDT) perimetry, measurement of intraocular pressure (IOP), and an interview concerning their history of glaucoma and use of drops to lower eye pressure...
December 29, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28011613/spinal-arachnoiditis-as-a-complication-of-cryptococcal-meningoencephalitis-in-non-hiv-previously-healthy-adults
#9
Anil A Panackal, Mika Komori, Peter Kosa, Omar Khan, Dima A Hammoud, Lindsey B Rosen, Sarah K Browne, Yen-Chih Lin, Elena Romm, Charu Ramaprasad, Bettina C Fries, John E Bennett, Bibiana Bielekova, Peter R Williamson
BACKGROUND: Cryptococcus can cause meningoencephalitis (CM) among previously healthy non-HIV adults. Spinal arachnoiditis is under-recognized, since diagnosis is difficult with concomitant central nervous system (CNS) pathology. METHODS: We describe 6 cases of spinal arachnoiditis among 26 consecutively recruited CM patients with normal CD4 counts who achieved microbiologic control. We performed detailed neurological exams, cerebrospinal fluid (CSF) immunophenotyping and biomarker analysis before and after adjunctive immunomodulatory intervention with high dose pulse corticosteroids, affording causal inference into pathophysiology...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28005971/the-anatomy-of-american-football-evidence-from-7-years-of-nfl-game-data
#10
Konstantinos Pelechrinis, Evangelos Papalexakis
How much does a fumble affect the probability of winning an American football game? How balanced should your offense be in order to increase the probability of winning by 10%? These are questions for which the coaching staff of National Football League teams have a clear qualitative answer. Turnovers are costly; turn the ball over several times and you will certainly lose. Nevertheless, what does "several" mean? How "certain" is certainly? In this study, we collected play-by-play data from the past 7 NFL seasons, i...
2016: PloS One
https://www.readbyqxmd.com/read/28005675/swept-source-optical-coherence-tomography-angiography-of-the-optic-disk-in-optic-neuropathy
#11
Khalil Ghasemi Falavarjani, Jack J Tian, Handan Akil, Giancarlo A Garcia, Srinivas R Sadda, Alfredo A Sadun
PURPOSE: To evaluate the optic nerve head microvasculature in eyes with acute and chronic optic neuropathies using swept-source optical coherence tomography angiography. METHODS: In this cross-sectional, observational study, optical coherence tomography angiography images were obtained from the optic nerve heads of 21 eyes of 12 patients with optic disk edema, pseudoedema and atrophy, and 12 eyes of 6 healthy subjects using a 1,050-nm optical coherence tomography angiography (Topcon DRI OCT; Triton)...
December 2016: Retina
https://www.readbyqxmd.com/read/28000086/interaction-of-small-heat-shock-proteins-with-light-component-of-neurofilaments-nfl
#12
Victoria V Nefedova, Maria V Sudnitsyna, Nikolai B Gusev
The interaction of human small heat shock protein HspB1, its point mutants associated with distal hereditary motor neuropathy, and three other small heat shock proteins (HspB5, HspB6, HspB8) with the light component of neurofilaments (NFL) was analyzed by differential centrifugation, analytical ultracentrifugation, and fluorescent spectroscopy. The wild-type HspB1 decreased the quantity of NFL in pellets obtained after low- and high-speed centrifugation and increased the quantity of NFL remaining in the supernatant after high-speed centrifugation...
December 20, 2016: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/27996900/tbi-and-nfl-culture-can-players-autonomously-refuse-biometric-monitoring
#13
Paul Cummins
No abstract text is available yet for this article.
January 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/27996330/suicide-in-professional-american-football-players-in-the-past-95-years
#14
David Webner, Grant L Iverson
OBJECTIVE: To examine publicly-available information on all identified cases of suicide in active or former American professional football players between 1920 and the spring of 2015. DESIGN: Retrospective cohort study. SETTING: Professional American Football in the US. PARTICIPANTS: A cohort of 26 702 athletes who had died, retired or were currently playing in the NFL from nfl.com since 1920 was identified. MAIN OUTCOME MEASURES: Internet queries identifying 26 professional football players who completed suicide...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27993286/pulse-transit-time-changes-in-subjects-exhibiting-sleep-disordered-breathing
#15
Biswajit Chakrabarti, Stephen Emegbo, Sonya Craig, Nick Duffy, John O'Reilly
INTRODUCTION: Pulse Transit Time (PTT) represents a non-invasive marker of sleep fragmentation in OSAS. Little is known regarding PTT in sleepy subjects exhibiting nocturnal Inspiratory Flow Limitation (IFL) in the absence of apneas or desaturation. MATERIALS AND METHODS: The IFL cohort was gender and age matched to subjects with OSAS and a cohort where Sleep Disordered Breathing (SBD)/IFL was absent ("Non Flow Limited" or NFL cohort); PTT Arousal index (PTT Ar) defined by number of PTT arousals per hour...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27967134/impact-of-time-delays-on-oscillatory-dynamics-of-interlinked-positive-and-negative-feedback-loops
#16
Bo Huang, Xinyu Tian, Feng Liu, Wei Wang
Interlinking a positive feedback loop (PFL) with a negative feedback loop (NFL) constitutes a typical motif in genetic networks, performing various functions in cell signaling. How time delay in feedback regulation affects the dynamics of such systems still remains unclear. Here, we investigate three systems of interlinked PFL and NFL with time delays: a synthetic genetic oscillator, a three-node circuit, and a simplified single-node model. The stability of steady states and the routes to oscillation in the single-node model are analyzed in detail...
November 2016: Physical Review. E
https://www.readbyqxmd.com/read/27965574/neurofilaments-in-csf-as-diagnostic-biomarkers-in-motor-neuron-disease-a-meta-analysis
#17
Dawei Li, Dongchao Shen, Hongfei Tai, Liying Cui
Objective: Neurofilaments in CSF are promising biomarkers which might help in the diagnosis of motor neuron disease (MND). We aim to assess the diagnostic value of neurofilaments in CSF for MND. Methods: Pubmed, Emabase, and Web of Science were searched for relevant studies systematically. Articles in English that evaluated the utility of neurofilaments in CSF in the diagnosis of MND were included. Data were extracted by two independent investigators. Diagnostic indexes for neurofilament light chain (NFL) and phosphorylated neurofilament heavy chain (pNFH) were calculated separately...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27957709/reduction-of-chemically-stable-multibonds-nitrogenase-like-biosynthesis-of-tetrapyrroles
#18
Gunhild Layer, Joern Krausze, Jürgen Moser
The sophisticated biochemistry of nitrogenase plays a fundamental role for the biosynthesis of tetrapyrrole molecules, acting as key components of photosynthesis and methanogenesis. Three nitrogenase-like metalloenzymes have been characterized to date. Synthesis of chlorophylls and bacteriochlorophylls involves the reduction of the C17-C18 double bond of the conjugated ring system of protochlorophyllide which is catalyzed by the multi-subunit enzyme dark operative protochlorophyllide oxidoreductase (DPOR). Subsequently, biosynthesis of all bacteriochlorophylls requires the reduction of the C7-C8 double bond by a second nitrogenase-like enzyme termed chlorophyllide oxidoreductase (COR)...
December 13, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27928414/leber-hereditary-optic-neuropathy-with-interval-of-visual-loss-greater-than-12-months
#19
Renata Cristina Ferreira Prado, Frederico Castelo Moura
A 28-year-old man presented with severe left visual loss and normal right visual acuity. The left fundus examination showed temporal pallor and complete absence of the nerve fibre layer (NFL) of papillomacular bundle. Right fundus examination showed focal loss of inferotemporal NFL. Magnetic resonance and serum aquaporin-4 antibody were negative. After 14 months of the initial visual involvement, the patient suffered subacute visual loss in contralateral eye. Genetic study revealed the 11778 point mitochondrial DNA (mtDNA) mutation associated with Leber hereditary optic neuropathy (LHON)...
October 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27921220/increased-cell-free-mitochondrial-dna-is-a-marker-of-ongoing-inflammation-and-better-neurocognitive-function-in-virologically-suppressed-hiv-infected-individuals
#20
Josué Pérez-Santiago, Michelli F De Oliveira, Susanna R Var, Tyler R C Day, Steven P Woods, Sara Gianella, Sanjay R Mehta
Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neurocognitive functioning in the context of long-term suppressive antiretroviral therapy (ART). We quantified the levels of cell-free mtDNA in the CSF from 41 HIV-infected individuals with completely suppressed HIV RNA levels in blood plasma (<50 copies/mL) by droplet digital PCR...
December 5, 2016: Journal of Neurovirology
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