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https://www.readbyqxmd.com/read/28915360/risk-factors-for-reoperation-and-performance-based-outcomes-after-operative-fixation-of-foot-fractures-in-the-professional-athlete-a-cross-sport-analysis
#1
Sameer Singh, Kevin Larkin, Anish Kadakia, Wellington Hsu
BACKGROUND: Professional athletes are predisposed to fractures of the foot due to large stresses placed on the lower extremity. These players are concerned with efficiently returning to play at a high level. Return-to-play rates after operative treatment have been previously reported, yet performance outcomes after such treatment are generally unknown in this population. HYPOTHESIS: Overall, professional athletes sustaining a foot fracture would return to play at high rates with little impact on post-operative performance or league participation...
September 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28902916/targeted-n-glycan-deletion-at-the-receptor-binding-site-retains-hiv-env-nfl-trimer-integrity-and-accelerates-the-elicited-antibody-response
#2
Viktoriya Dubrovskaya, Javier Guenaga, Natalia de Val, Richard Wilson, Yu Feng, Arlette Movsesyan, Gunilla B Karlsson Hedestam, Andrew B Ward, Richard T Wyatt
Extensive shielding by N-glycans on the surface of the HIV envelope glycoproteins (Env) restricts B cell recognition of conserved neutralizing determinants. Elicitation of broadly neutralizing antibodies (bNAbs) in selected HIV-infected individuals reveals that Abs capable of penetrating the glycan shield can be generated by the B cell repertoire. Accordingly, we sought to determine if targeted N-glycan deletion might alter antibody responses to Env. We focused on the conserved CD4 binding site (CD4bs) since this is a known neutralizing determinant that is devoid of glycosylation to allow CD4 receptor engagement, but is ringed by surrounding N-glycans...
September 13, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28894758/the-latarjet-procedure-at-the-national-football-league-scouting-combine-an-imaging-and-performance-analysis
#3
George F LeBus, Jorge Chahla, George Sanchez, Ramesses Akamefula, Gilbert Moatshe, Alexandra Phocas, Mark D Price, James M Whalen, Robert F LaPrade, Matthew T Provencher
BACKGROUND: The Latarjet procedure is commonly performed in the setting of glenoid bone loss for treatment of recurrent anterior shoulder instability; however, little is known regarding the outcomes of this procedure in elite American football players. PURPOSE: (1) Determine the prevalence, clinical features, and imaging findings of elite college football athletes who present to the National Football League (NFL) Combine with a previous Latarjet procedure and (2) describe these athletes' performance in the NFL in terms of draft status and initial playing time...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28872485/what-is-the-value-of-a-national-football-league-draft-pick-an-analysis-based-on-changes-made-in-the-collective-bargaining-agreement
#4
Matthew J Kraeutler, Trevor J Carver, John W Belk, Eric C McCarty
The purpose of this study was to analyze and compare the value of players drafted in early rounds of the NFL Draft since the new collective bargaining agreement (CBA) began in 2011. The NFL's player statistics database and database of player contract details were searched for players drafted in the first three rounds of the 2011 to 2013 NFL Drafts. Performance outcomes specific to each position were divided by each player's salary to calculate a value statistic. Various demographics, NFL Combine results, and total number of games missed due to injury were also recorded for each player...
June 2, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28846089/oscillatory-stimuli-differentiate-adapting-circuit-topologies
#5
Sahand Jamal Rahi, Johannes Larsch, Kresti Pecani, Alexander Y Katsov, Nahal Mansouri, Krasimira Tsaneva-Atanasova, Eduardo D Sontag, Frederick R Cross
Biology emerges from interactions between molecules, which are challenging to elucidate with current techniques. An orthogonal approach is to probe for 'response signatures' that identify specific circuit motifs. For example, bistability, hysteresis, or irreversibility are used to detect positive feedback loops. For adapting systems, such signatures are not known. Only two circuit motifs generate adaptation: negative feedback loops (NFLs) and incoherent feed-forward loops (IFFLs). On the basis of computational testing and mathematical proofs, we propose differential signatures: in response to oscillatory stimulation, NFLs but not IFFLs show refractory-period stabilization (robustness to changes in stimulus duration) or period skipping...
August 28, 2017: Nature Methods
https://www.readbyqxmd.com/read/28840151/epidemiology-of-navicular-injury-at-the-nfl-combine-and-their-impact-on-an-athlete-s-prospective-nfl-career
#6
Bryan Vopat, Brendin R Beaulieu-Jones, Gregory Waryasz, Kevin J McHale, George Sanchez, Catherine A Logan, James M Whalen, Christopher W DiGiovanni, Matthew T Provencher
BACKGROUND: Navicular injuries can result in persistent pain, posttraumatic osteoarthritis, and diminished performance and function. PURPOSE: To determine the epidemiology of navicular fracture in players participating in the National Football League (NFL) Scouting Combine and evaluate the impact of a navicular injury on the NFL draft position and NFL game play compared with matched controls. STUDY DESIGN: Cohort study; Level of evidence, 3...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28840148/prevalence-and-impact-of-glenoid-augmentation-in-american-football-athletes-participating-in-the-national-football-league-scouting-combine
#7
Derrick M Knapik, Robert J Gillespie, Michael J Salata, James E Voos
BACKGROUND: Bony augmentation of the anterior glenoid is used in athletes with recurrent shoulder instability and bone loss; however, the prevalence and impact of repair in elite American football athletes are unknown. PURPOSE: To evaluate the prevalence and impact of glenoid augmentation in athletes invited to the National Football League (NFL) Scouting Combine from 2012 to 2015. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: A total of 1311 athletes invited to the NFL Combine from 2012 to 2015 were evaluated for history of either Bristow or Latarjet surgery for recurrent anterior shoulder instability...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28840146/performance-and-return-to-sport-after-clavicle-open-reduction-and-internal-fixation-in-national-football-league-players
#8
Robert A Jack, Kyle R Sochacki, Sergio M Navarro, Patrick C McCulloch, David M Lintner, Joshua D Harris
BACKGROUND: Clavicle fractures are common injuries in professional football. Surgical fixation of these injuries may lead to decreased nonunion rates, improved shoulder strength, and decreased residual functional impairment. PURPOSE: To determine (1) return-to-sport (RTS) rate in National Football League (NFL) players after clavicle fracture open reduction and internal fixation (ORIF), (2) postoperative career length and games per season, (3) pre- and postoperative performance, and (4) postoperative performance compared with control players matched by position, age, years of experience, and performance...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28835663/choroid-plexitis-and-ependymitis-by-magnetic-resonance-imaging-are-biomarkers-of-neuronal-damage-and-inflammation-in-hiv-negative-cryptococcal-meningoencephalitis
#9
Dima A Hammoud, Eman Mahdi, Anil A Panackal, Paul Wakim, Virginia Sheikh, Irini Sereti, Bibi Bielakova, John E Bennett, Peter R Williamson
CNS cryptococcal meningoencephalitis in both HIV positive (HIV+) and HIV negative (HIV-) subjects is associated with high morbidity and mortality despite optimal antifungal therapy. We thus conducted a detailed analysis of the MR imaging findings in 45 HIV- and 11 HIV+ patients to identify imaging findings associated with refractory disease. Ventricular abnormalities, namely ependymitis and choroid plexitis were seen in HIV- but not in HIV+ subjects. We then correlated the imaging findings in a subset of HIV- subjects (n = 17) to CSF levels of neurofilament light chain (NFL), reflective of axonal damage and sCD27, known to best predict the presence of intrathecal T-cell mediated inflammation...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28831853/defining-active-progressive-multiple-sclerosis
#10
Finn Sellebjerg, Lars Börnsen, Cecilie Ammitzbøll, Jørgen Erik Nielsen, Tua Vinther-Jensen, Lena Elisabeth Hjermind, Marina von Essen, Rikke Lenhard Ratzer, Per Soelberg Sørensen, Jeppe Romme Christensen
BACKGROUND: It is unknown whether disease activity according to consensus criteria (magnetic resonance imaging activity or clinical relapses) associate with cerebrospinal fluid (CSF) changes in progressive multiple sclerosis (MS). OBJECTIVE: To compare CSF biomarkers in active and inactive progressive MS according to consensus criteria. METHODS: Neurofilament light chain (NFL), myelin basic protein (MBP), IgG-index, chitinase-3-like-1 (CHI3L1), matrix metalloproteinase-9 (MMP-9), chemokine CXCL13, terminal complement complex, leukocyte counts and nitric oxide metabolites were measured in primary ( n = 26) and secondary progressive MS ( n = 26) and healthy controls ( n = 24)...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28820611/nutrient-content-claims-how-they-impact-perceived-healthfulness-of-fortified-snack-foods-and-the-moderating-effects-of-nutrition-facts-labels
#11
Irina A Iles, Xiaoli Nan, Linda Verrill
Nutrient content claims (NCCs) may inflate perceived healthfulness of nutritionally poor foods. The aim of this study is to experimentally test the effects of NCCs on consumers' perceptions of fortified snack foods in terms of the presence of both healthful and less healthful nutrients, as well as their intentions to consume such products. It also explores the potential moderating effects of reading Nutrition Facts Labels (NFL) on the influence of NCCs. Data for this study were collected through a web-based experiment (N = 5,076)...
August 18, 2017: Health Communication
https://www.readbyqxmd.com/read/28814415/optical-coherence-tomography-angiography-enhances-the-detection-of-optic-nerve-damage-in-multiple-sclerosis
#12
Rebecca I Spain, Liang Liu, Xinbo Zhang, Yali Jia, Ou Tan, Dennis Bourdette, David Huang
BACKGROUND: Quantitative assessment of optic nerve damage is important in the evaluation of optic neuritis (ON) and multiple sclerosis (MS). OBJECTIVE: To detect optic nerve damage using optical coherence tomography (OCT) and OCT angiography in MS. METHODS: Peripapillary retinal nerve fibre layer (NFL) thickness, macular ganglion cell complex (GCC) thickness and Optic Nerve Head Flow Index (ONH-FI) were measured. The ONH-FI was defined as flow signal averaged over the optic disc...
August 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28812033/epidemiology-of-injuries-identified-at-the-nfl-scouting-combine-and-their-impact-on-performance-in-the-national-football-league-evaluation-of-2203-athletes-from-2009-to-2015
#13
Brendin R Beaulieu-Jones, William H Rossy, George Sanchez, James M Whalen, Kyle P Lavery, Kevin J McHale, Bryan G Vopat, Joseph J Van Allen, Ramesses A Akamefula, Matthew T Provencher
BACKGROUND: At the annual National Football League (NFL) Scouting Combine, the medical staff of each NFL franchise performs a comprehensive medical evaluation of all athletes potentially entering the NFL. Currently, little is known regarding the overall epidemiology of injuries identified at the combine and their impact on NFL performance. PURPOSE: To determine the epidemiology of injuries identified at the combine and their impact on initial NFL performance. STUDY DESIGN: Cohort study; Level of evidence, 3...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28810748/chronic-traumatic-encephalopathy-cte-a-brief-historical-overview-and-recent-focus-on-nfl-players
#14
Craig W Lindsley
No abstract text is available yet for this article.
August 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28804762/-super-bowl-babies-do-counties-with-super-bowl-winning-teams-experience-increases-in-births-nine-months-later
#15
George M Hayward, Anna Rybińska
Following the claim of a highly publicized National Football League (NFL) commercial, we test whether the Super Bowl provides a positive exogenous shock to fertility in counties of winning teams. Using stadium locations to identify teams' counties, we analyze the number of births in counties of both winning and losing teams for ten recent Super Bowls. We also test for state effects and general effects of the NFL playoffs. Overall, our results show no clear pattern of increases in the number of births in winning counties nine months after the Super Bowl...
January 2017: Socius
https://www.readbyqxmd.com/read/28796876/the-distribution-of-leakage-on-fluorescein-angiography-in-diabetic-macular-edema-a-new-approach-to-its-etiology
#16
RANDOMIZED CONTROLLED TRIAL
Bilal Haj Najeeb, Christian Simader, Gabor Deak, Clemens Vass, Jutta Gamper, Alessio Montuoro, Bianca S Gerendas, Ursula Schmidt-Erfurth
Purpose: To determine the distribution of leakage on fluorescein angiography (FA) and explore the clinically protective role of astrocytes against damage to the inner blood retinal barrier (iBRB) in diabetic macular edema (DME). Methods: A consecutive case series of 87 eyes of 87 patients with DME was included. We measured the leakage area in each field of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid on late-phase FA images. The normative thickness of the nerve fiber layer (NFL), in which the astrocytes are confined, was derived from a previous work using spectral-domain optical coherence tomography...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28796875/optical-coherence-tomography-analysis-based-prediction-of-humphrey-24-2-visual-field-thresholds-in-patients-with-glaucoma
#17
Zhihui Guo, Young H Kwon, Kyungmoo Lee, Kai Wang, Andreas Wahle, Wallace L M Alward, John H Fingert, Daniel I Bettis, Chris A Johnson, Mona K Garvin, Milan Sonka, Michael D Abràmoff
Purpose: A pilot study showed that prediction of individual Humphrey 24-2 visual field (HVF 24-2) sensitivity thresholds from optical coherence tomography (OCT) image analysis is possible. We evaluate performance of an improved approach as well as 3 other predictive algorithms on a new, fully independent set of glaucoma subjects. Methods: Subjects underwent HVF 24-2 and 9-field OCT (Heidelberg Spectralis) testing. Nerve fiber (NFL), and ganglion cell and inner plexiform (GCL+IPL) layers were cosegmented and partitioned into 52 sectors matching HVF 24-2 test locations...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28776634/performance-and-return-to-sport-after-nonoperative-treatment-of-clavicle-fractures-in-national-football-league-players
#18
Robert A Jack, Kyle R Sochacki, Sergio M Navarro, Patrick C McCulloch, David M Lintner, Joshua D Harris
Clavicle fractures are often seen in contact sports. The purpose of this study was to determine (1) return-to-sport (RTS) rate of National Football League (NFL) players following nonoperative treatment of clavicle fractures, (2) posttreatment career length and games per season, (3) pre- and posttreatment performance, and (4) posttreatment performance compared with control players matched by position, age, years of experience, and performance. Public records were used to identify NFL players who underwent nonoperative treatment of clavicle fractures...
August 3, 2017: Orthopedics
https://www.readbyqxmd.com/read/28774516/diagnostic-accuracy-of-ganglion-cell-complex-substructures-in-different-stages-of-primary-open-angle-glaucoma
#19
Amal M Elbendary, Mohamed Hafez Abd El-Latef, Hisham I Elsorogy, Kamal M Enaam
OBJECTIVE: To evaluate diagnostic accuracy of substructure of ganglion cell complex versus peripapillary nerve fiber layer (NFL) thickness using spectral domain optical coherence tomography (SD-OCT) in different stages of glaucoma. METHODS: Thirty eyes were normal, 120 were glaucomatous. Glaucomatous eyes were classified into: early glaucoma (46), moderate glaucoma (48), and severe glaucoma (26). Perimetry and SD-OCT were done. Peripapillary NFL thickness, ganglion cell layer (GCL), macular NFL thickness, combined GCL and macular ganglion cell complex (GCC), were recorded...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28753688/the-role-of-neck-muscle-activities-on-the-risk-of-mild-traumatic-brain-injury-in-american-football
#20
Xin Jin, Zhaoying Feng, Valerie Mika, Haiyan Li, David C Viano, King H Yang
Concussion, or mild traumatic brain injury (mTBI), is frequently associated with sports activities. It has generally been accepted that neck strengthening exercises are effective as a preventive strategy for reducing sports-related concussion risks. However, the interpretation of the link between neck strength and concussion risks remains unclear. In this study, a typical helmeted head-to-head impact in American football was simulated using the head and neck complex finite element (FE) model. The impact scenario selected was previously reported in lab-controlled incident reconstructions from high-speed video footages of the National Football League using two head-neck complexes taken from Hybrid III dummies...
October 1, 2017: Journal of Biomechanical Engineering
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