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https://www.readbyqxmd.com/read/27921220/increased-cell-free-mitochondrial-dna-is-a-marker-of-ongoing-inflammation-and-better-neurocognitive-function-in-virologically-suppressed-hiv-infected-individuals
#1
Josué Pérez-Santiago, Michelli F De Oliveira, Susanna R Var, Tyler R C Day, Steven P Woods, Sara Gianella, Sanjay R Mehta
Cell-free mitochondrial DNA (mtDNA) is a highly immunogenic molecule that is associated with several inflammatory conditions and with neurocognitive impairment during untreated HIV infection. Here, we investigate how cell-free mtDNA in cerebrospinal fluid (CSF) is associated with inflammation, neuronal damage, and neurocognitive functioning in the context of long-term suppressive antiretroviral therapy (ART). We quantified the levels of cell-free mtDNA in the CSF from 41 HIV-infected individuals with completely suppressed HIV RNA levels in blood plasma (<50 copies/mL) by droplet digital PCR...
December 5, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27919454/the-longitudinal-impact-of-nfl-play-60-programming-on-youth-aerobic-capacity-and-bmi
#2
Yang Bai, Pedro F Saint-Maurice, Gregory J Welk, Daniel W Russell, Kelly Allums-Featherston, Norma Candelaria
INTRODUCTION: The NFL PLAY 60 campaign has actively promoted physical activity and healthy eating in youth through programs such as the PLAY 60 Challenge and Fuel Up to PLAY 60. The purpose of the study was to evaluate the impact of NFL PLAY 60 programming on longitudinal trajectories of youth aerobic capacity and BMI. STUDY DESIGN: Data were from the NFL PLAY 60 FitnessGram Partnership Project, a large participatory research project designed to promote physical activity and healthy eating among Kindergarten through 12th grade children and adolescents...
December 2, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27896490/cerebrospinal-fluid-levels-of-neurofilament-light-chain-in-multiple-system-atrophy-relative-to-parkinson-s-disease-a-meta-analysis
#3
Xiaohui Hu, Yan Yang, Daokai Gong
As a biomarker of axonal injury, neurofilament light chain (NFL) in multiple system atrophy (MSA) patients and Parkinson's disease (PD) patients has been investigated by numerous studies. However, cerebrospinal fluid (CSF) NFL changes are conflicting in MSA patients relative to PD patients to date. Therefore, the current study was carried out to find out possible heterogeneity sources. Furthermore, "Neurofilament", "Neurofilament light chain" and "Multiple system atrophy" were employed to search "PubMed", "Springer" and "Medline" databases until August 2016 with standard mean difference (Std...
November 28, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27893897/imaging-of-glial-cell-activation-and-white-matter-integrity-in-brains-of-active-and-recently-retired-national-football-league-players
#4
Jennifer M Coughlin, Yuchuan Wang, Il Minn, Nicholas Bienko, Emily B Ambinder, Xin Xu, Matthew E Peters, John W Dougherty, Melin Vranesic, Soo Min Koo, Hye-Hyun Ahn, Merton Lee, Chris Cottrell, Haris I Sair, Akira Sawa, Cynthia A Munro, Christopher J Nowinski, Robert F Dannals, Constantine G Lyketsos, Michael Kassiou, Gwenn Smith, Brian Caffo, Susumu Mori, Tomas R Guilarte, Martin G Pomper
Importance: Microglia, the resident immune cells of the central nervous system, play an important role in the brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single and repeated traumatic brain injury, possibly through sports-related concussive and subconcussive injuries. Limited in vivo brain imaging studies months to years after individuals experience a single moderate to severe traumatic brain injury suggest widespread persistent microglial activation, but there has been little study of persistent glial cell activity in brains of athletes with sports-related traumatic brain injury...
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27893483/game-times-and-higher-winning-percentages-of-west-coast-teams-of-the-national-football-league-correspond-with-reduced-prevalence-of-regular-season-injury
#5
Allison J Brager, R Justin Mistovich
West coast teams of the National Football League (NFL) are more statistically likely to win home night games against east coast opponents. The alignment of game times with daily rhythms of alertness is thought to contribute to this advantage. The present study aims to determine if rates of turnovers and injuries during the regular season, putative measures of mental and physical fatigue, impact winning percentages. Regular season schedules and rates of turnovers for each of the thirty-two teams were obtained from Pro-Football-Reference...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27875493/acute-lumbar-paraspinal-myonecrosis-in-football-players-with-sickle-cell-trait-a-case-series
#6
E Randy Eichner, Brock Schnebel, Scott Anderson, James R Clugston, Heath Hale, Charlie Michaudet, John M Small
We report 6 cases of a novel syndrome of acute, exertional low back pain (LBP) in football players, 5 in college and one in the National Football League (NFL). All 6 are African-Americans with sickle cell trait (SCT). The acute LBP is severe and can be disabling, and the condition can be confused with muscle strain, discogenic pain, stress fracture, or other problems in athletes. Our evidence shows that this syndrome is caused by lumbar paraspinal myonecrosis (LPSMN), which likely often contributes to the lumbar paraspinal compartment syndrome...
November 21, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27870090/the-dual-role-of-nfl-team-doctors
#7
Marvin Washington
Glenn Cohen, Holly Fernandez Lynch, and Christopher Deubert are right in their article "A Proposal to Address NFL Club Doctors' Conflicts of Interest and to Promote Player Trust" that the problem with the medical care rendered to National Football League players is not that the doctors are bad, but that the system in which they provide care is structured badly. We saw some of the problems this system causes last season in what happened to Case Kenum, a quarterback for the Los Angeles Rams who, despite having a possible concussion from a game injury, was allowed to continue to play, with a concussion spotter in the booth and coaches, teammates, seven game officials, and two full training staffs present...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27870089/lessons-for-the-nfl-from-workers-compensation
#8
Richard Diana
In the article "A Proposal to Address NFL Club Doctors' Conflicts of Interest and to Promote Player Trust," Glenn Cohen et al. write, "The [NFL's] current structure forces club doctors to have obligations to two parties-the club and the player-and to make difficult judgments about when one party's interests must yield to another's." I can understand why some might be suspicious about bias in the current NFL medical system, in which the club doctors have a professional duty to put their player-patients' best interests first yet are employed by clubs, which have a primary goal of winning football games...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27870087/nfl-physicians-committed-to-excellence-in-patient-player-care
#9
(no author information available yet)
The National Football League Physicians Society read with disappointment the article "A Proposal to Address NFL Club Doctors' Conflicts of Interest and to Promote Player Trust." In spite of the authors' suggestions, NFL physicians are accomplished medical professionals who abide by the highest ethical standards in providing treatment to all of their patients, including those who play in the NFL. It defies logic for the authors not to have engaged experienced and active NFL physicians from the very start of their effort to explore, challenge, and recommend significant alterations to the delivery of health care to NFL players...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27870086/health-care-for-nfl-players-upholding-physician-standards-and-enhancing-the-doctor-patient-relationship
#10
Laurent Duvernay-Tardif
Beginning my third year with the Kansas City Chiefs and being also a medical student at McGill University, I was at first a little reluctant to comment on Glenn Cohen et al.'s critique of the National Football League's structure involving player health and team doctors, but the opportunity to provide a perspective as both a football player and a medical student was too much to forgo. Because of my athletic and academic background, I am often asked what I think about injuries in professional sports and about the role of sports medicine physicians, and Cohen et al...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27870084/a-response-to-commentaries
#11
I Glenn Cohen, Holly Fernandez Lynch, Christopher R Deubert
Our article "NFL Player Health Care: Addressing Club Doctors' Conflicts of Interests and Promoting Player Trust" focused on an inherent structural conflict that faces club doctors in the National Football League. The conflict stems from club doctors' dual role of providing medical care to players and providing strategic advice to clubs. We recommended assigning these roles to different individuals, with the medical staff members who are responsible for providing player care being chosen and subject to review and termination by a committee of medical experts selected equally by the NFL and the NFL Players Association...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27870083/being-right-isn-t-always-enough-nfl-culture-and-team-physicians-conflict-of-interest
#12
Ross McKinney
The job of being a sports team physician is difficult, regardless of the level, from high school to the National Football League. When a sports league receives the intensity of attention leveled at the NFL, though, a difficult occupation becomes even more challenging. Even for the NFL players themselves, players' best interests regarding health issues are often unclear. Football players are, as a lot, highly competitive individuals. They want to win, and they want to help the team win. It's a warrior culture, and respect is earned by playing hurt...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27870082/a-proposal-to-address-nfl-club-doctors-conflicts-of-interest-and-to-promote-player-trust
#13
I Glenn Cohen, Holly Fernandez Lynch, Christopher R Deubert
How can we ensure that players in the National Football League receive excellent health care they can trust from providers who are as free from conflicts of interest as realistically possible? NFL players typically receive care from the club's own medical staff. Club doctors are clearly important stakeholders in player health. They diagnose and treat players for a variety of ailments, physical and mental, while making recommendations to the player concerning those ailments. At the same time, club doctors have obligations to the club, namely to inform and advise clubs about the health status of players...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27870081/preventing-conflicts-of-interest-of-nfl-team-physicians
#14
Mark A Rothstein
At least since the time of Hippocrates, the physician-patient relationship has been the paradigmatic ethical arrangement for the provision of medical care. Yet, a physician-patient relationship does not exist in every professional interaction involving physicians and individuals they examine or treat. There are several "third-party" relationships, mostly arising where the individual is not a patient and is merely being examined rather than treated, the individual does not select or pay the physician, and the physician's services are provided for the benefit of another party...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27868081/blood-brain-barrier-integrity-intrathecal-immunoactivation-and-neuronal-injury-in-hiv
#15
Birgitta Anesten, Aylin Yilmaz, Lars Hagberg, Henrik Zetterberg, Staffan Nilsson, Bruce J Brew, Dietmar Fuchs, Richard W Price, Magnus Gisslén
OBJECTIVE: Although blood-brain barrier (BBB) impairment has been reported in HIV-infected individuals, characterization of this impairment has not been clearly defined. METHODS: BBB integrity was measured by CSF/plasma albumin ratio in this cross-sectional study of 631 HIV-infected individuals and 71 controls. We also analyzed CSF and blood HIV RNA and neopterin, CSF leukocyte count, and neurofilament light chain protein (NFL) concentrations. The HIV-infected participants included untreated neuroasymptomatic patients, patients with untreated HIV-associated dementia (HAD), and participants on suppressive antiretroviral treatment (ART)...
December 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27865642/attention-to-physical-activity-equivalent-calorie-information-on-nutrition-facts-labels-an%C3%A2-eye-tracking-investigation
#16
Julia A Wolfson, Dan J Graham, Sara N Bleich
OBJECTIVE: Investigate attention to Nutrition Facts Labels (NFLs) with numeric only vs both numeric and activity-equivalent calorie information, and attitudes toward activity-equivalent calories. DESIGN: An eye-tracking camera monitored participants' viewing of NFLs for 64 packaged foods with either standard NFLs or modified NFLs. Participants self-reported demographic information and diet-related attitudes and behaviors. SETTING: Participants came to the Behavioral Medicine Lab at Colorado State University in spring, 2015...
November 16, 2016: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/27826598/variables-affecting-return-to-play-after-anterior-cruciate-ligament-injury-in-the-national-football-league
#17
Emmanuel D Eisenstein, Nathaniel L Rawicki, Nicholas J Rensing, Nicholas A Kusnezov, Joseph T Lanzi
BACKGROUND: Anterior cruciate ligament (ACL) injuries are common in the National Football League (NFL). Limited literature exists regarding return to play (RTP) and the factors affecting RTP after ACL reconstruction in NFL players. PURPOSE/HYPOTHESIS: To determine RTP rates after ACL reconstruction in NFL players and to ascertain which variables affect RTP in these players. We hypothesized that RTP in this population will be less than in the general population and similar to the limited studies published previously...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27794264/csf-neurofilament-light-levels-predict-hippocampal-atrophy-in-cognitively-healthy-older-adults
#18
Ane-Victoria Idland, Roser Sala-Llonch, Tom Borza, Leiv Otto Watne, Torgeir Bruun Wyller, Anne Brækhus, Henrik Zetterberg, Kaj Blennow, Kristine Beate Walhovd, Anders Martin Fjell
Cerebrospinal fluid (CSF) neurofilament light (NFL) is a marker of axonal degeneration. We tested whether CSF NFL levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established CSF Alzheimer's disease (AD) biomarkers, β-amyloid 1-42, and phosphorylated tau (P-tau). We included 144 participants in a 2-year longitudinal study with baseline CSF measures and 2 magnetic resonance images. Eighty-eight participants had full data available. A subgroup of 36 participants with very low AD risk was also studied...
September 28, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27793805/superior-labrum-anterior-posterior-tears-in-the-national-football-league
#19
Caitlin C Chambers, T Sean Lynch, Daniel B Gibbs, Jason H Ghodasra, Shawn Sahota, Kristina Franke, Christina D Mack, Gordon W Nuber
BACKGROUND: Shoulder disorders are common in football players, with up to 50% of National Football League (NFL) recruits reporting a history of shoulder injuries. Superior labrum anterior-posterior (SLAP) tears are an entity with well-described detrimental effects on return to play in overhead-throwing athletes but with minimal data in contact athletes. PURPOSE: To identify the incidence, predisposing factors, and effect of SLAP tears in NFL athletes and prospects as well as the treatment patterns of NFL team physicians...
October 28, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27787906/cerebrospinal-fluid-biomarkers-as-a-measure-of-disease-activity-and-treatment-efficacy-in-relapsing-remitting-multiple-sclerosis
#20
Lenka Novakova, Markus Axelsson, Mohsen Khademi, Henrik Zetterberg, Kaj Blennow, Clas Malmeström, Fredrik Piehl, Tomas Olsson, Jan Lycke
Cerebrospinal fluid (CSF) biomarkers can reflect different aspects of the pathophysiology of relapsing-remitting multiple sclerosis (RRMS). Understanding the impact of different disease modifying therapies on the CSF biomarker profile may increase their implementation in clinical practice and their appropriateness for monitoring treatment efficacy. This study investigated the influence of first-line (interferon beta) and second-line (natalizumab) therapies on seven CSF biomarkers in RRMS and their correlation with clinical and radiological outcomes...
October 27, 2016: Journal of Neurochemistry
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