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https://www.readbyqxmd.com/read/28812033/epidemiology-of-injuries-identified-at-the-nfl-scouting-combine-and-their-impact-on-performance-in-the-national-football-league-evaluation-of-2203-athletes-from-2009-to-2015
#1
Brendin R Beaulieu-Jones, William H Rossy, George Sanchez, James M Whalen, Kyle P Lavery, Kevin J McHale, Bryan G Vopat, Joseph J Van Allen, Ramesses A Akamefula, Matthew T Provencher
BACKGROUND: At the annual National Football League (NFL) Scouting Combine, the medical staff of each NFL franchise performs a comprehensive medical evaluation of all athletes potentially entering the NFL. Currently, little is known regarding the overall epidemiology of injuries identified at the combine and their impact on NFL performance. PURPOSE: To determine the epidemiology of injuries identified at the combine and their impact on initial NFL performance. STUDY DESIGN: Cohort study; Level of evidence, 3...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28810748/chronic-traumatic-encephalopathy-cte-a-brief-historical-overview-and-recent-focus-on-nfl-players
#2
Craig W Lindsley
No abstract text is available yet for this article.
August 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28804762/-super-bowl-babies-do-counties-with-super-bowl-winning-teams-experience-increases-in-births-nine-months-later
#3
George M Hayward, Anna Rybińska
Following the claim of a highly publicized National Football League (NFL) commercial, we test whether the Super Bowl provides a positive exogenous shock to fertility in counties of winning teams. Using stadium locations to identify teams' counties, we analyze the number of births in counties of both winning and losing teams for ten recent Super Bowls. We also test for state effects and general effects of the NFL playoffs. Overall, our results show no clear pattern of increases in the number of births in winning counties nine months after the Super Bowl...
January 2017: Socius
https://www.readbyqxmd.com/read/28796876/the-distribution-of-leakage-on-fluorescein-angiography-in-diabetic-macular-edema-a-new-approach-to-its-etiology
#4
Bilal Haj Najeeb, Christian Simader, Gabor Deak, Clemens Vass, Jutta Gamper, Alessio Montuoro, Bianca S Gerendas, Ursula Schmidt-Erfurth
Purpose: To determine the distribution of leakage on fluorescein angiography (FA) and explore the clinically protective role of astrocytes against damage to the inner blood retinal barrier (iBRB) in diabetic macular edema (DME). Methods: A consecutive case series of 87 eyes of 87 patients with DME was included. We measured the leakage area in each field of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid on late-phase FA images. The normative thickness of the nerve fiber layer (NFL), in which the astrocytes are confined, was derived from a previous work using spectral-domain optical coherence tomography...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28796875/optical-coherence-tomography-analysis-based-prediction-of-humphrey-24-2-visual-field-thresholds-in-patients-with-glaucoma
#5
Zhihui Guo, Young H Kwon, Kyungmoo Lee, Kai Wang, Andreas Wahle, Wallace L M Alward, John H Fingert, Daniel I Bettis, Chris A Johnson, Mona K Garvin, Milan Sonka, Michael D Abràmoff
Purpose: A pilot study showed that prediction of individual Humphrey 24-2 visual field (HVF 24-2) sensitivity thresholds from optical coherence tomography (OCT) image analysis is possible. We evaluate performance of an improved approach as well as 3 other predictive algorithms on a new, fully independent set of glaucoma subjects. Methods: Subjects underwent HVF 24-2 and 9-field OCT (Heidelberg Spectralis) testing. Nerve fiber (NFL), and ganglion cell and inner plexiform (GCL+IPL) layers were cosegmented and partitioned into 52 sectors matching HVF 24-2 test locations...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28776634/performance-and-return-to-sport-after-nonoperative-treatment-of-clavicle-fractures-in-national-football-league-players
#6
Robert A Jack, Kyle R Sochacki, Sergio M Navarro, Patrick C McCulloch, David M Lintner, Joshua D Harris
Clavicle fractures are often seen in contact sports. The purpose of this study was to determine (1) return-to-sport (RTS) rate of National Football League (NFL) players following nonoperative treatment of clavicle fractures, (2) posttreatment career length and games per season, (3) pre- and posttreatment performance, and (4) posttreatment performance compared with control players matched by position, age, years of experience, and performance. Public records were used to identify NFL players who underwent nonoperative treatment of clavicle fractures...
August 3, 2017: Orthopedics
https://www.readbyqxmd.com/read/28774516/diagnostic-accuracy-of-ganglion-cell-complex-substructures-in-different-stages-of-primary-open-angle-glaucoma
#7
Amal M Elbendary, Mohamed Hafez Abd El-Latef, Hisham I Elsorogy, Kamal M Enaam
OBJECTIVE: To evaluate diagnostic accuracy of substructure of ganglion cell complex versus peripapillary nerve fiber layer (NFL) thickness using spectral domain optical coherence tomography (SD-OCT) in different stages of glaucoma. METHODS: Thirty eyes were normal, 120 were glaucomatous. Glaucomatous eyes were classified into: early glaucoma (46), moderate glaucoma (48), and severe glaucoma (26). Perimetry and SD-OCT were done. Peripapillary NFL thickness, ganglion cell layer (GCL), macular NFL thickness, combined GCL and macular ganglion cell complex (GCC), were recorded...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28753688/the-role-of-neck-muscle-activities-on-the-risk-of-mild-traumatic-brain-injury-in-american-football
#8
Xin Jin, Zhaoying Feng, Valerie H Mika, Haiyan Li, David Viano, King H Yang
Concussion, or mild TBI (mTBI), is frequently associated with sports activities. It has generally been accepted that neck strengthening exercises are effective as a preventive strategy for reducing sports-related concussion risks. However, the interpretation of the link between neck strength and concussion risks remains unclear. In this study, a typical helmeted head-to-head impact in American football was simulated using the head and neck complex finite element model. The impact scenario selected was previously reported in lab-controlled incident reconstructions from high-speed NFL video footages using two head-neck complexes taken from Hybrid III dummies...
July 28, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28742993/performance-and-return-to-sport-after-achilles-tendon-repair-in-national-football-league-players
#9
Robert A Jack, Kyle R Sochacki, Stephanie S Gardner, Patrick C McCulloch, David M Lintner, Pedro E Cosculluela, Kevin E Varner, Joshua D Harris
BACKGROUND: Achilles tendon injuries are common in sports, including football. The purpose of this study was to determine (1) return-to-sport rate in National Football League (NFL) players following Achilles tendon repair, (2) postoperative career length and games per season, (3) pre- and postoperative performance, and (4) postoperative performance compared with control players matched by position, age, years of experience, and performance. METHODS: Publicly available records were used to identify NFL players who underwent Achilles tendon repair and matched controls were identified...
July 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28733960/a-review-of-fluid-biomarkers-for-alzheimer-s-disease-moving-from-csf-to-blood
#10
REVIEW
Kaj Blennow
A set of core cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) includes total tau (T-tau), phosphorylated tau (P-tau) and β-amyloid 42 (Aβ42). These biomarkers reflect some of the key aspects of AD pathophysiology, including neuronal degeneration, tau phosphorylation with tangle formation, and Aβ aggregation with deposition of the peptide into plaques. The core AD CSF biomarkers have been validated clinically in numerous studies, and found to have a very high diagnostic performance to identify AD, both in the dementia and in the mild cognitive impairment stages of the disease...
July 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28692877/association-between-cerebrospinal-fluid-and-plasma-neurodegeneration-biomarkers-with-brain-atrophy-in-alzheimer-s-disease
#11
Joana B Pereira, Eric Westman, Oskar Hansson
The aggregation and deposition of amyloid-β (Aβ) peptides into plaques is an early event in Alzheimer's disease (AD), which is followed by different aspects of neurodegeneration that can be measured in the cerebrospinal fluid (CSF) or plasma using neurofilament light (NFL), neurogranin (Ng), total Tau (T-Tau), and phosphorylated tau (P-Tau) levels. The relationship between these biomarkers and regional brain atrophy across the different stages of AD remains largely unexplored. In this study, we assessed whether NFL, Ng, T-Tau, and P-Tau levels in CSF and NFL in plasma are associated with cortical thinning and subcortical volume loss in cognitively normal, mild cognitive impairment, and AD subjects with and without Aβ pathology...
June 17, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28689355/vitamin-d3-reverses-the-hippocampal-cytoskeleton-imbalance-but-not-memory-deficits-caused-by-ovariectomy-in-adult-wistar-rats
#12
Cassiana Siebert, Paula Pierozan, Janaina Kolling, Tiago Marcon Dos Santos, Matheus Coimbra Sebotaio, Eduardo Peil Marques, Helena Biasibetti, Aline Longoni, Fernanda Ferreira, Regina Pessoa-Pureur, Carlos Alexandre Netto, Angela T S Wyse
The objective of study was to investigate changes caused by ovariectomy (OVX) on aversive and non-aversive memories, as well as on cytoskeleton phosphorylating system and on vitamin D receptor (VDR) immunocontent in hippocampus. The neuroprotective role of vitamin D was also investigated. Ninety-day-old female Wistar rats were divided into four groups: SHAM, OVX, VITAMIN D and OVX + VITAMIN D; 30 days after the OVX, vitamin D supplementation (500 IU/kg), by gavage, for 30 days was started. Results showed that OVX impaired short-term and long-term recognition, and long-term aversive memories...
July 8, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28680893/return-to-sport-and-performance-after-anterior-cruciate-ligament-reconstruction-in-national-football-league-linemen
#13
Mark E Cinque, Charles P Hannon, Daniel D Bohl, Brandon J Erickson, Nikhil N Verma, Brian J Cole, Bernard R Bach
BACKGROUND: Tears of the anterior cruciate ligament (ACL) are common in the National Football League (NFL). The impact of these injuries on the careers of NFL linemen is unknown. PURPOSE: To define the percentage of NFL linemen who return to sport (RTS) after ACL reconstruction, the mean time to RTS, and the impact on performance compared with matched controls. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Data on NFL offensive and defensive linemen who sustained an ACL tear and underwent ACL reconstruction between 1980 and 2015 were analyzed...
June 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28679595/poor-sleep-is-associated-with-csf-biomarkers-of-amyloid-pathology-in-cognitively-normal-adults
#14
Kate E Sprecher, Rebecca L Koscik, Cynthia M Carlsson, Henrik Zetterberg, Kaj Blennow, Ozioma C Okonkwo, Mark A Sager, Sanjay Asthana, Sterling C Johnson, Ruth M Benca, Barbara B Bendlin
OBJECTIVE: To determine the relationship between sleep quality and CSF markers of Alzheimer disease (AD) pathology in late midlife. METHODS: We investigated the relationship between sleep quality and CSF AD biomarkers in a cohort enriched for parental history of sporadic AD, the Wisconsin Registry for Alzheimer's Prevention. A total of 101 participants (mean age 62.9 ± 6.2 years, 65.3% female) completed sleep assessments and CSF collection and were cognitively normal...
August 1, 2017: Neurology
https://www.readbyqxmd.com/read/28658072/the-nfl-combine-40-yard-dash-how-important-is-maximum-velocity
#15
Kenneth P Clark, Randall H Rieger, Richard F Bruno, David J Stearne
This investigation analyzed the sprint velocity profiles for athletes who completed the 40-yard (36.6m) dash at the 2016 NFL Combine. The purpose was to evaluate the relationship between maximum velocity and sprint performance, and to compare acceleration patterns for fast and slow athletes. Using freely available online sources, data were collected for body mass and sprint performance (36.6m time with split intervals at 9.1 and 18.3m). For each athlete, split times were utilized to generate modeled curves of distance vs...
June 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28654681/abnormal-neurofilament-inclusions-and-segregations-in-dorsal-root-ganglia-of-a-charcot-marie-tooth-type-2e-mouse-model
#16
Jian Zhao, Kristy Brown, Ronald K H Liem
Charcot-Marie-Tooth (CMT) disease or hereditary motor and sensory neuropathy is the most prevalent inherited peripheral neuropathy and is associated with over 90 causative genes. Mutations in neurofilament light polypeptide gene, NEFL cause CMT2E, an axonal form of CMT that results in abnormal structures and/or functions of peripheral axons in spinal cord motor neurons and dorsal root ganglion neurons. We have previously generated and characterized a knock-in mouse model of CMT2E with the N98S mutation in Nefl that presented with multiple inclusions in spinal cord neurons...
2017: PloS One
https://www.readbyqxmd.com/read/28644678/professional-athletes-return-to-play-and-performance-after-operative-repair-of-an-achilles-tendon-rupture
#17
David P Trofa, J Chance Miller, Eugene S Jang, Denzel R Woode, Justin K Greisberg, J Turner Vosseller
BACKGROUND: Most Achilles tendon ruptures are sports related. However, few studies have examined and compared the effect of surgical repair for complete ruptures on return to play (RTP), play time, and performance across multiple sports. PURPOSE: To examine RTP and performance among professional athletes after Achilles tendon repair and compare pre- versus postoperative functional outcomes of professional athletes from different major leagues in the United States...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28635102/ratiometric-analysis-of-optical-coherence-tomography-measured-in%C3%A2-vivo-retinal-layer-thicknesses-for-the-detection-of-early-diabetic-retinopathy
#18
Basanta Bhaduri, Ryan L Shelton, Ryan M Nolan, Lucas Hendren, Alexandra Almasov, Leanne T Labriola, Stephen A Boppart
Influence of diabetes mellitus (DM) and diabetic retinopathy (DR) on parafoveal retinal thicknesses and their ratios was evaluated. Six retinal layer boundaries were segmented from spectral-domain optical coherence tomography images using open-source software. Five study groups: (1) healthy control (HC) subjects, and subjects with (2) controlled DM, (3) uncontrolled DM, (4) controlled DR and (5) uncontrolled DR, were identified. The one-way analyses of variance (ANOVA) between adjacent study groups (i. e...
June 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28631955/cerebrospinal-fluid-neurofilament-light-concentration-in-motor-neuron-disease-and-frontotemporal-dementia-predicts-survival
#19
Tobias Skillbäck, Niklas Mattsson, Kaj Blennow, Henrik Zetterberg
OBJECTIVE: To aid diagnostics, patient stratification and studies seeking to find treatments for the related diseases motor neuron disease (MND) and frontotemporal dementia (FTD), there is a need to establish a way to assess disease severity and the amount of ongoing neurodegeneration. Previous studies have suggested that cerebrospinal fluid (CSF) neurofilament light (NFL) may serve this purpose. METHODS: We cross-referenced the Swedish mortality registry with the laboratory database at Sahlgrenska University Hospital to produce a dataset of CSF NFL concentrations and mortality information for 715 MND patients, 87 FTD patients, and 107 healthy controls...
February 6, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28627962/plasma-neurofilament-light-chain-levels-in-patients-with-ms-switching-from-injectable-therapies-to-fingolimod
#20
Fredrik Piehl, Ingrid Kockum, Mohsen Khademi, Kaj Blennow, Jan Lycke, Henrik Zetterberg, Tomas Olsson
BACKGROUND: Neurofilament light chain (NFL) is a cerebrospinal fluid (CSF) marker of neuroaxonal damage in multiple sclerosis (MS). OBJECTIVE: To determine the correlation of NFL in CSF and serum/plasma, and in plasma after switching from injectable MS therapies to fingolimod. METHODS: A first cohort consisted of MS patients ( n = 39) and neurological disease controls ( n = 27) where CSF and plasma/serum had been collected for diagnostic purposes...
June 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
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