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https://www.readbyqxmd.com/read/29337583/sudden-death-aversion-avoiding-superior-options-because-they-feel-riskier
#1
Jesse Walker, Jane L Risen, Thomas Gilovich, Richard Thaler
We present evidence of sudden-death aversion (SDA)-the tendency to avoid "fast" strategies that provide a greater chance of success, but include the possibility of immediate defeat, in favor of "slow" strategies that reduce the possibility of losing quickly, but have lower odds of ultimate success. Using a combination of archival analyses and controlled experiments, we explore the psychology behind SDA. First, we provide evidence for SDA and its cost to decision makers by tabulating how often NFL teams send games into overtime by kicking an extra point rather than going for the 2-point conversion (Study 1) and how often NBA teams attempt potentially game-tying 2-point shots rather than potentially game-winning 3-pointers (Study 2)...
January 15, 2018: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/29328927/alzheimer-s-disease-biomarker-guided-diagnostic-workflow-using-the-added-value-of-six-combined-cerebrospinal-fluid-candidates-a%C3%AE-1-42-total-tau-phosphorylated-tau-nfl-neurogranin-and-ykl-40
#2
Harald Hampel, Nicola Toschi, Filippo Baldacci, Henrik Zetterberg, Kaj Blennow, Ingo Kilimann, Stefan J Teipel, Enrica Cavedo, Antonio Melo Dos Santos, Stéphane Epelbaum, Foudil Lamari, Remy Genthon, Bruno Dubois, Roberto Floris, Francesco Garaci, Simone Lista
INTRODUCTION: The diagnostic and classificatory performances of all combinations of three core (amyloid β peptide [i.e., Aβ1-42], total tau [t-tau], and phosphorylated tau) and three novel (neurofilament light chain protein, neurogranin, and YKL-40) cerebrospinal fluid biomarkers of neurodegeneration were compared among individuals with mild cognitive impairment (n = 41), Alzheimer's disease dementia (ADD; n = 35), frontotemporal dementia (FTD; n = 9), and cognitively healthy controls (HC; n = 21), using 10-fold cross-validation...
January 9, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29321234/plasma-neurofilament-light-chain-concentration-in-the-inherited-peripheral-neuropathies
#3
Åsa Sandelius, Henrik Zetterberg, Kaj Blennow, Rocco Adiutori, Andrea Malaspina, Matilde Laura, Mary M Reilly, Alexander M Rossor
OBJECTIVE: To perform a cross-sectional study to determine whether plasma neurofilament light chain (NfL) concentration is elevated in patients with Charcot-Marie-Tooth disease (CMT) and if it correlates with disease severity. METHODS: Blood samples were collected from 75 patients with CMT and 67 age-matched healthy controls over a 1-year period. Disease severity was measured using the Rasch modified CMT Examination and neuropathy scores. Plasma NfL concentration was measured using an in-house-developed Simoa assay...
January 10, 2018: Neurology
https://www.readbyqxmd.com/read/29318176/venous-thromboembolism-within-professional-american-sport-leagues
#4
Meghan Bishop, Matthew Astolfi, Eric Padegimas, Peter DeLuca, Sommer Hammoud
Background: Numerous reports have described players in professional American sports leagues who have been sidelined with a deep vein thrombosis (DVT) or a pulmonary embolism (PE), but little is known about the clinical implications of these events in professional athletes. Purpose: To conduct a retrospective review of injury reports from the National Hockey League (NHL), Major League Baseball (MLB), the National Basketball Association (NBA), and the National Football League (NFL) to take a closer look at the incidence of DVT/PE, current treatment approaches, and estimated time to return to play in professional athletes...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29288365/methylphenidate-disrupts-cytoskeletal-homeostasis-and-reduces-membrane-associated-lipid-content-in-juvenile-rat-hippocampus
#5
Felipe Schmitz, Paula Pierozan, Helena Biasibetti-Brendler, Fernanda Silva Ferreira, Fernanda Dos Santos Petry, Vera Maria Treis Trindade, Regina Pessoa-Pureur, Angela T S Wyse
Although methylphenidate (MPH) is ubiquitously prescribed to children and adolescents, the consequences of chronic utilization of this psychostimulant are poorly understood. In this study, we investigated the effects of MPH on cytoskeletal homeostasis and lipid content in rat hippocampus. Wistar rats received intraperitoneal injections of MPH (2.0 mg/kg) or saline solution (controls), once a day, from the 15th to the 44th day of age. Results showed that MPH provoked hypophosphorylation of glial fibrillary acidic protein (GFAP) and reduced its immunocontent...
December 29, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29282336/csf-neurofilament-light-chain-and-phosphorylated-tau-181-predict-disease-progression-in-psp
#6
Julio C Rojas, Jee Bang, Iryna V Lobach, Richard M Tsai, Gil D Rabinovici, Bruce L Miller, Adam L Boxer
OBJECTIVE: To determine the ability of CSF biomarkers to predict disease progression in progressive supranuclear palsy (PSP). METHODS: We compared the ability of baseline CSF β-amyloid1-42, tau, phosphorylated tau 181 (p-tau), and neurofilament light chain (NfL) concentrations, measured by INNO-BIA AlzBio3 or ELISA, to predict 52-week changes in clinical (PSP Rating Scale [PSPRS] and Schwab and England Activities of Daily Living [SEADL]), neuropsychological, and regional brain volumes on MRI using linear mixed effects models controlled for age, sex, and baseline disease severity, and Fisher F density curves to compare effect sizes in 50 patients with PSP...
December 27, 2017: Neurology
https://www.readbyqxmd.com/read/29275983/the-association-of-vitamin-d-status-in-lower-extremity-muscle-strains-and-core-muscle-injuries-at-the-national-football-league-combine
#7
Brian J Rebolledo, Johnathan A Bernard, Brian C Werner, Andrea K Finlay, Benedict U Nwachukwu, David M Dare, Russell F Warren, Scott A Rodeo
PURPOSE: To evaluate the association between serum vitamin D level and the prevalence of lower extremity muscle strains and core muscle injuries in elite level athletes at the National Football League (NFL) combine. METHODS: During the 2015 NFL combine, all athletes with available serum vitamin D levels were included for study. Baseline data were collected, including age, race, body mass index, position, injury history specific to lower extremity muscle strain or core muscle injury, and Functional Movement Screen scores...
December 19, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29244833/genomic-characterization-and-molecular-evolution-analysis-of-subtype-b-and-bf-recombinant-hiv-1-strains-among-argentinean-men-who-have-sex-with-men-reveal-a-complex-scenario
#8
Cintia G Cevallos, Leandro R Jones, Maria A Pando, Jean K Carr, Maria M Avila, Jorge Quarleri
Currently, data on HIV-1 circulating strains among men who have sex with men (MSM) in Argentina is scarce. In South America, the distribution and the prevalence of BF recombinants are dissimilar and exhibit an underappreciated heterogeneity of recombinant structures. Here, we studied for the first time the genetic diversity of HIV-1 BF recombinants and their evolution over time through in-depth phylogenetic analysis and multiple recombination detection methods involving 337 HIV-1 nucleotide sequences (25 near full-length (NFL) and 312 partial pol gene) obtained from Argentinean MSM...
2017: PloS One
https://www.readbyqxmd.com/read/29237796/csf-neurofilament-light-concentration-is-increased-in-presymptomatic-chmp2b-mutation-carriers
#9
Nina Rostgaard, Peter Roos, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Anja H Simonsen, Jørgen E Nielsen
OBJECTIVE: A rare cause of familial frontotemporal dementia (FTD) is a mutation in the CHMP2B gene on chromosome 3 (FTD-3), described in a Danish family. Here we examine whether CSF biomarkers change in the preclinical phase of the disease. METHODS: In this cross-sectional explorative study, we analyzed CSF samples from 16 mutation carriers and 14 noncarriers from the Danish FTD-3 family. CSF biomarkers included total tau (t-tau) and neurofilament light chain (NfL) as a marker for neurodegeneration, phosphorylated tau (p-tau) as a marker for tau pathology, β-amyloid (Aβ) 38, 40, and 42 (Aβ38, Aβ40, and Aβ42) to monitor Aβ metabolism, and YKL-40 as a marker of neuroinflammation...
December 13, 2017: Neurology
https://www.readbyqxmd.com/read/29230223/glutaraldehyde-cross-linking-of-hiv-1-env-trimers-skews-the-antibody-subclass-response-in-mice
#10
Martina Soldemo, Monika Àdori, Julian M Stark, Yu Feng, Karen Tran, Richard Wilson, Lifei Yang, Javier Guenaga, Richard T Wyatt, Gunilla B Karlsson Hedestam
Well-ordered soluble HIV-1 envelope glycoprotein (Env) spike mimetics such as Native Flexibly Linked (NFL) trimers display high homogeneity, desired antigenicity, and high in vitro stability compared to previous generation soluble HIV-1 Env trimers. Glutaraldehyde (GLA) cross-linking was shown to further increase the thermostability of clade C 16055 NFL trimers and enhance the induction of tier 2 autologous neutralizing antibodies in guinea pigs. Here, we investigated if GLA fixation affected other aspects of the Env-specific immune response by performing a comparative immunogenicity study in C57BL/6 mice with non-fixed and GLA-fixed 16055 NFL trimers administered in AbISCO-100 adjuvant...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29226165/game-schedules-and-rate-of-concussions-in-the-national-football-league
#11
Masaru Teramoto, Daniel M Cushman, Chad L Cross, Heather M Curtiss, Stuart E Willick
Background: Concussion prevention in the National Football League (NFL) is an important priority for player safety. The NFL now has modified game schedules, and one concern is that unconventional game schedules, such as a shortened rest period due to playing on a Thursday rather than during the weekend, may lead to an increased risk of injuries. Hypothesis: Unconventional game schedules in the NFL are associated with an increased rate of concussion. Study Design: Descriptive epidemiological study...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29226164/short-term-outcomes-following-concussion-in-the-nfl-a-study-of-player-longevity-performance-and-financial-loss
#12
Sergio M Navarro, Olumide F Sokunbi, Heather S Haeberle, Mark S Schickendantz, Michael A Mont, Richard A Figler, Prem N Ramkumar
Background: A short-term protocol for evaluation of National Football League (NFL) athletes incurring concussion has yet to be fully defined and framed in the context of the short-term potential team and career longevity, financial risk, and performance. Purpose: To compare the short-term career outcomes for NFL players with concussions by analyzing the effect of concussions on (1) franchise release rate, (2) career length, (3) salary, and (4) performance. Study Design: Cohort study; Level of evidence, 3...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29225016/posterior-cruciate-ligament-injuries-of-the-knee-at-the-national-football-league-combine-an-imaging-and-epidemiology-study
#13
Catherine A Logan, Brendin R Beaulieu-Jones, George Sanchez, Jorge Chahla, Nicholas I Kennedy, Mark E Cinque, Robert F LaPrade, James M Whalen, Bryan G Vopat, Mark D Price, Matthew T Provencher
PURPOSE: To determine the epidemiology by player position, examination, imaging findings, and associated injuries of posterior cruciate ligament (PCL) injuries in players participating in the National Football League (NFL) Combine. METHODS: All PCL injuries identified at the NFL Combine (2009-2015) were reviewed. Data were obtained from the database organized by the NFL medical personnel for the compilation of the medical and physical performance examination results of NFL Draftees participating in the NFL Combine from 2009 to 2015...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29225015/symptomatic-focal-knee-chondral-injuries-in-national-football-league-combine-players-are-associated-with-poorer-performance-and-less-volume-of-play
#14
Matthew T Provencher, Jorge Chahla, Mark E Cinque, George Sanchez, Nicholas I Kennedy, Daniel B Haber, Ashley J Tisosky, Brendin R Beaulieu-Jones, Mark D Price, James M Whalen, Gilbert Moatshe, Robert F LaPrade
PURPOSE: To (1) describe the magnetic resonance imaging (MRI) characteristics of knee chondral injuries identified at the National Football League (NFL) Combine and (2) assess in-game performance of prospective NFL players with previously untreated knee chondral injuries and compare it with matched controls. METHODS: All players with knee chondral injuries identified at the NFL Combine (2009-2015) were retrospectively reviewed. Players with prior knee surgery were excluded...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29219886/impact-of-clavicle-fractures-on-return-to-play-and-performance-ratings-in-nfl-athletes
#15
Darshan Vora, Matthew Baker, Rajeev Pandarinath
OBJECTIVE: Clavicle fractures in the National Football League (NFL) have gained significant attention because of their impact on high profile athletes; however, little has been published on the overall impact of these injuries. This study sought to determine the time to return to play and quantitative impact on athletic performance after clavicle fractures in NFL athletes. DESIGN: Retrospective Cohort Study; Level of evidence, 3. SETTING: Retrospective cohort study of NFL athletes based on published injury reports and player statistics...
December 1, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29212830/multicenter-evaluation-of-neurofilaments-in-early-symptom-onset-amyotrophic-lateral-sclerosis
#16
Emily Feneberg, Patrick Oeckl, Petra Steinacker, Federico Verde, Christian Barro, Philip Van Damme, Elizabeth Gray, Julian Grosskreutz, Claude Jardel, Jens Kuhle, Sonja Koerner, Foudil Lamari, Maria Del Mar Amador, Benjamin Mayer, Claudia Morelli, Petra Muckova, Susanne Petri, Koen Poesen, Joost Raaphorst, François Salachas, Vincenzo Silani, Beatrice Stubendorff, Martin R Turner, Marcel M Verbeek, Jochen H Weishaupt, Patrick Weydt, Albert C Ludolph, Markus Otto
OBJECTIVE: To examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS). METHODS: We measured Nf light chain (NfL) and phosphorylated Nf heavy chain (pNfH) CSF and NfL serum levels in patients with ALS with first symptom onset ≤6 months (n = 54) or >6 months (n = 135) from sampling, and patients with other neurologic diseases, differential diagnoses of a motor neuron disease (MND mimics), and other MND variants to determine the diagnostic accuracy in patients with ALS with early symptom onset...
January 2, 2018: Neurology
https://www.readbyqxmd.com/read/29201991/white-matter-signal-abnormalities-in-former-national-football-league-players
#17
Michael L Alosco, Inga K Koerte, Yorghos Tripodis, Megan Mariani, Alicia S Chua, Johnny Jarnagin, Yashar Rahimpour, Christian Puzo, Rose C Healy, Brett Martin, Christine E Chaisson, Robert C Cantu, Rhoda Au, Michael McClean, Ann C McKee, Alexander P Lin, Martha E Shenton, Ronald J Killiany, Robert A Stern
Introduction: Later-life brain alterations in former tackle football players are poorly understood, particularly regarding their relationship with repetitive head impacts (RHIs) and clinical function. We examined white matter signal abnormalities (WMSAs) and their association with RHIs and clinical function in former National Football League (NFL) players. Methods: Eighty-six clinically symptomatic former NFL players and 23 same-age reportedly asymptomatic controls without head trauma exposure underwent magnetic resonance imaging and neuropsychological testing...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29176385/positional-differences-in-running-and-non-running-activities-during-elite-american-football-training
#18
Patrick A Ward, Sam Ramsden, Aaron J Coutts, Andrew T Hulton, Barry Drust
The aim of this investigation was to describe differences in training loads between position groups within professional American football. Integrated micro technology data was collected on 63 NFL football players during an American football training camp. Five key metrics (total distance, high speed distance, Player Load, Player Load per Minute, and Total Inertial Movement Analysis (IMA)) served to quantify both running and non-running activities. Players were classified into position groups (DB, DL, LB, OL, QB, RB, TE, and WR)...
November 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29175306/embodiment-in-the-aging-mind
#19
REVIEW
Esther Kuehn, Mario Borja Perez-Lopez, Nadine Diersch, Juliane Döhler, Thomas Wolbers, Martin Riemer
Bodily awareness is a central component of human sensation, action, and cognition. The human body is subject to profound changes over the adult lifespan. We live in an aging society: the mean age of people living in industrialized countries is currently over 40 years, and further increases are expected. Nevertheless, there is a lack of comprehensive knowledge that links changes in embodiment that occur with age to neuronal mechanisms and associated sensorimotor and cognitive deficits in the elderly. Here, we synthesize existing evidence and introduce the NFL Framework of Embodied Aging, which links basic neuronal (N) mechanisms of age-related sensorimotor decline to changes in functional (F) bodily impairments, including deficits in higher-level cognitive functions, and impairments in daily life (L)...
November 22, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29168666/diagnostic-methods-used-in-searching-for-markers-of-atrophy-in-patients-with-multiple-sclerosis
#20
Przemyslaw Puz, Arkadiusz Steposz, Anetta Lasek-Bal, Karina Bartoszek, Patrycja Radecka, Aleksandra Karuga-Pierścieńska
The results of available studies on assessment of neurodegenerative lesions in multiple sclerosis (MS) patients using different approaches have not been conclusive. Currently, clinical assessment is the most commonly used (involving primarily mobility assessment), along with magnetic resonance imaging and electrophysiological testing. In this review we describe available clinical, neuroimaging, electrophysiological and laboratory tests used to assess the neurodegeneration in MS. Laboratory markers to determine the risk of disease, its conversion and prognosis in MS patients are being constantly sought...
November 23, 2017: Neurological Research
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