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https://www.readbyqxmd.com/read/29150682/enantioselective-transformation-of-fluoxetine-in-water-and-its-ecotoxicological-relevance
#1
María Jesús Andrés-Costa, Kathryn Proctor, Marco T Sabatini, Anthony P Gee, Simon E Lewis, Yolanda Pico, Barbara Kasprzyk-Hordern
European legislation focusing on water quality is expected to broaden to encompass several pharmaceuticals as priority hazardous substances. This manuscript aims to challenge current regulatory approaches that do not recognize stereochemistry of chiral pharmaceuticals by testing the hypothesis that environmental transformation and effects of chiral pharmaceuticals are stereoselective. Our experiments revealed that, while degradation of chiral fluoxetine (FL) in river water occurs via non-enantioselective photochemical and mildly-enantioselective microbial processes favoring the (R)-enantiomer, a pronounced enantioselectivity favoring (S)-FL (leading to the formation of (S)-NFL (norfluoxetine)) is observed during activated sludge treatment...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29149238/diabetic-neuroglial-changes-in-the-superficial-and-deep-nonperfused-areas-on-optical-coherence-tomography-angiography
#2
Yoko Dodo, Tomoaki Murakami, Kiyoshi Suzuma, Shin Yoshitake, Tatsuya Yoshitake, Kenji Ishihara, Masahiro Fujimoto, Yuko Miwa, Akitaka Tsujikawa
Purpose: To evaluate the relationship between lamellar capillary nonperfusion on optical coherence tomography angiography (OCTA) images and neuroglial changes on structural optical coherence tomography (OCT) images in diabetic retinopathy (DR). Methods: We retrospectively reviewed 101 consecutive eyes of 69 patients with DR. OCTA and OCT images within a 3 × 3-mm square centered on the fovea were acquired simultaneously. The nonperfused areas (NPAs) in the superficial capillary layer (sNPA) (from the nerve fiber layer [NFL] to the inner plexiform layer [IPL]), the deep layer (dNPA) (corresponding mainly to the inner nuclear layer [INL]), or both layers (bNPA) were measured individually along 10 transverse lines...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29148030/incidence-and-quantitative-analysis-of-dissociated-optic-nerve-fiber-layer-appearance-real-loss-of-retinal-nerve-fiber-layer
#3
Yoon J Kim, Kyoung S Lee, Soo G Joe, June-Gone Kim
PURPOSE: To assess the association between appearance of dissociated optic nerve fiber layer (DONFL) after internal limiting membrane (ILM) peeling and changes in the macular nerve fiber layer (NFL) area by spectral-domain optical coherence tomography (SD-OCT). METHODS: This study included 132 consecutive patients who had successfully undergone vitrectomy with ILM peeling for idiopathic epiretinal membrane or macular holes and had been followed up for ≥6 months...
November 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29146160/posterolateral-corner-injuries-of-the-knee-at-the-national-football-league-combine-an-imaging-and-outcomes-analysis
#4
Jorge Chahla, Nicholas I Kennedy, Mark E Cinque, George Sanchez, Catherine Logan, Bryan G Vopat, Brendin Beaulieu-Jones, Mark Price, Jim Whalen, Robert F LaPrade, Matthew T Provencher
PURPOSE: (1) To determine the epidemiology, examination findings, imaging findings, and associated injuries of posterolateral corner (PLC) injuries in players participating in the National Football League (NFL) Combine and (2) to evaluate the impact of PLC injuries on performance compared with matched controls. METHODS: All PLC injuries identified at the NFL Combine between 2009 and 2015 were reviewed. The inclusion criteria were any player who had clinical findings or a previous surgical procedure consistent with a PLC injury and who participated in medical and performance testing at the NFL Combine...
November 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29142020/time-out-nfl-conflicts-of-interest-with-public-health-efforts-to-prevent-tbi
#5
Kathleen E Bachynski, Daniel S Goldberg
No abstract text is available yet for this article.
November 15, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29125088/cerebrospinal-fluid-biomarkers-as-predictors-of-shunt-response-in-idiopathic-normal-pressure-hydrocephalus-a-systematic-review
#6
Tyler Pfanner, Alexandre Henri-Bhargava, Stephanie Borchert
BACKGROUND: The widely accepted treatment for idiopathic normal-pressure hydrocephalus (iNPH) is a cerebrospinal fluid (CSF) diversion shunt procedure, to which approximately 80% of patients will respond. The purpose of this systematic review was to identify which CSF biomarkers have been investigated in predicting shunt responsiveness in iNPH patients, and to analyze the level of evidence for each. METHODS: To find all relevant articles, a comprehensive search of Medline, Embase, and PsycINFO was conducted...
November 10, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29122845/ascending-aortic-dimensions-in-former-national-football-league-athletes
#7
James L Gentry, David Carruthers, Parag H Joshi, Christopher D Maroules, Colby R Ayers, James A de Lemos, Philip Aagaard, Rory Hachamovitch, Milind Y Desai, Eric E Roselli, Reginald E Dunn, Kezia Alexander, Andrew E Lincoln, Andrew M Tucker, Dermot M Phelan
BACKGROUND: Ascending aortic dimensions are slightly larger in young competitive athletes compared with sedentary controls, but rarely >40 mm. Whether this finding translates to aortic enlargement in older, former athletes is unknown. METHODS AND RESULTS: This cross-sectional study involved a sample of 206 former National Football League (NFL) athletes compared with 759 male subjects from the DHS-2 (Dallas Heart Study-2; mean age of 57.1 and 53.6 years, respectively, P<0...
November 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29112467/meniscectomy-and-resultant-articular-cartilage-lesions-of-the-knee-among-prospective-national-football-league-players-an-imaging-and-performance-analysis
#8
Jorge Chahla, Mark E Cinque, Jonathan A Godin, George Sanchez, George F Lebus, James M Whalen, Mark D Price, Nicholas I Kennedy, Gilbert Moatshe, Robert F LaPrade, Matthew T Provencher
BACKGROUND: The effect of prior meniscectomy and the resulting reduction in meniscal tissue on a potential National Football League (NFL) player's articular cartilage status and performance remain poorly elucidated. Purpose/Hypothesis: (1) To determine the epidemiology, imaging characteristics, and associated articular cartilage pathology of the knee among players with a previous meniscectomy who were participating in the NFL Combine and (2) to evaluate the effect of these injuries on performance as compared with matched controls...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29102567/clinical-and-radiologic-outcomes-after-scaphoid-fracture-injury-and-treatment-patterns-in-national-football-league-combine-athletes-between-2009-and-2014
#9
Gilbert Moatshe, Jonathan A Godin, Jorge Chahla, Mark E Cinque, Nicholas I Kennedy, George Sanchez, Brendin R Beaulieu-Jones, Robert F LaPrade, Matthew T Provencher
PURPOSE: To report on the clinical and radiologic outcomes and complications after surgical treatment in National Football League (NFL) Combine athletes with a history of a scaphoid fracture. METHODS: The medical records of 2,285 athletes participating in the NFL Combine from 2009 to 2015 were evaluated for a history of scaphoid, hand, or wrist injury. Clinical outcomes, including grip strength, pinch test, range of motion, and presence of pain and stiffness, were recorded...
November 1, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29096697/race-modifies-the-relationship-between-cognition-and-alzheimer-s-disease-cerebrospinal-fluid-biomarkers
#10
Jennifer C Howell, Kelly D Watts, Monica W Parker, Junjie Wu, Alexander Kollhoff, Thomas S Wingo, Cornelya D Dorbin, Deqiang Qiu, William T Hu
BACKGROUND: African Americans have been reported to have a higher prevalence of Alzheimer's disease (AD) than Caucasians, but etiology-specific AD biomarkers have not been systematically analyzed in older African Americans. Coexisting cerebrovascular disease may also contribute to this increased prevalence. We hypothesized that cerebrospinal fluid (CSF) biomarkers of amyloid, neurodegeneration, and endothelial dysfunction would differ between older African Americans and Caucasians with normal cognition and cognitive impairment associated with AD...
November 2, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29079686/monitoring-disease-activity-in-multiple-sclerosis-using-serum-neurofilament-light-protein
#11
Lenka Novakova, Henrik Zetterberg, Peter Sundström, Markus Axelsson, Mohsen Khademi, Martin Gunnarsson, Clas Malmeström, Anders Svenningsson, Tomas Olsson, Fredrik Piehl, Kaj Blennow, Jan Lycke
OBJECTIVE: To examine the effects of disease activity, disability, and disease-modifying therapies (DMTs) on serum neurofilament light (NFL) and the correlation between NFL concentrations in serum and CSF in multiple sclerosis (MS). METHODS: NFL concentrations were measured in paired serum and CSF samples (n = 521) from 373 participants: 286 had MS, 45 had other neurologic conditions, and 42 were healthy controls (HCs). In 138 patients with MS, the serum and CSF samples were obtained before and after DMT treatment with a median interval of 12 months...
October 27, 2017: Neurology
https://www.readbyqxmd.com/read/29077640/risk-and-causes-of-death-among-former-national-football-league-players-1986-2012
#12
Andrew E Lincoln, Robert A Vogel, Thomas W Allen, Reginald E Dunn, Kezia Alexander, Nathaniel D Kaufman, Andrew M Tucker
PURPOSE: Previous research identified decreased overall and cardiovascular mortality for National Football League (NFL) players from the 1959-1988 era. The present study explored the mortality risk among recent NFL players who played in an era of heavier linemen and nearly year-round physical conditioning. METHODS: This cohort study included 9778 former NFL players with at least one year in the NFL whose last season was between 1986 and 2012. Players' pension fund records were matched to the National Death Index (NDI) to determine vital status, date of death, and cause of death...
October 26, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29074982/neurofilament-light-protein-in-csf-and-blood-is-associated-with-neurodegeneration-and-disease-severity-in-huntington-s-disease-r6-2-mice
#13
Rana Soylu-Kucharz, Åsa Sandelius, Marie Sjögren, Kaj Blennow, Edward J Wild, Henrik Zetterberg, Maria Björkqvist
There is an unmet need to reliably and non-invasively monitor disease progression in preclinical Huntington's disease (HD) models. As a marker of axonal damage, neurofilament light chain (NfL) has been suggested a marker for neurodegeneration. NfL concentrations in blood and CSF were recently shown to have prognostic value for clinical HD progression and brain atrophy. We therefore hypothesized that CSF and blood NfL concentrations could be useful preclinical HD markers, reflecting underlying pathology. To test our hypothesis we utilized the R6/2 mouse model of HD and measured NfL concentrations in CSF and serum using the ultrasensitive Single molecule array (Simoa) platform...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29070659/serum-neurofilament-light-in-familial-alzheimer-disease-a-marker-of-early-neurodegeneration
#14
Philip S J Weston, Teresa Poole, Natalie S Ryan, Akshay Nair, Yuying Liang, Kirsty Macpherson, Ronald Druyeh, Ian B Malone, R Laila Ahsan, Hugh Pemberton, Jana Klimova, Simon Mead, Kaj Blennow, Martin N Rossor, Jonathan M Schott, Henrik Zetterberg, Nick C Fox
OBJECTIVES: To investigate whether serum neurofilament light (NfL) concentration is increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and whether it is associated with markers of disease stage and severity. METHODS: We recruited 48 individuals from families with PSEN1 or APP mutations to a cross-sectional study: 18 had symptomatic Alzheimer disease (AD) and 30 were asymptomatic but at 50% risk of carrying a mutation. Serum NfL was measured using an ultrasensitive immunoassay on the single molecule array (Simoa) platform...
October 25, 2017: Neurology
https://www.readbyqxmd.com/read/29067334/effect-of-physical-exercise-on-markers-of-neuronal-dysfunction-in-cerebrospinal-fluid-in-patients-with-alzheimer-s-disease
#15
Camilla Steen Jensen, Erik Portelius, Peter Høgh, Lene Wermuth, Kaj Blennow, Henrik Zetterberg, Steen Gregers Hasselbalch, Anja Hviid Simonsen
INTRODUCTION: Physical exercise has gained increasing focus as a potential mean to maintain cognitive function in patients with Alzheimer's disease (AD). Alongside the markers of specific AD pathology (amyloid β and tau), other pathologies such as neuronal damage and synaptic loss have been proposed as markers of the disease. Here, we study the effect of physical exercise on biomarkers of neuronal and synaptic integrity. METHODS: Cerebrospinal fluid (CSF) from 51 AD subjects who participated in the randomized controlled trial Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) was analyzed for the concentration of neurofilament light (NFL), neurogranin (Ng), visinin-like protein-1 (VILIP-1), and chitinase-3-like protein 1 (YKL-40)...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29060430/concussion-management-application-for-amateur-sports
#16
J D Fischer, G H Smith, R S Rodrigues, M R Afzal, D J van den Heever, P L Viviers, J T Viljoen
Concussion management has become one of the most popular topics in sports medicine. Significant resources are being invested in developing protocols for professional sport associations such as the NFL and FIFA. These protocols are often expensive and require substantial resources to implement. The problem, however, runs much deeper than just professional sports. Currently there exists little infrastructure to effectively manage concussion in amateur settings such as high school, club and university sport. A more holistic approach is required to ensure that the same standard of concussion management is being implemented across the board, regardless of the available medical and financial resources...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29049718/wide-field-oct-angiography-investigation-of-the-relationship-between-radial-peripapillary-capillary-plexus-density-and-nerve-fiber-layer-thickness
#17
Yali Jia, Joseph M Simonett, Jie Wang, Xiaohui Hua, Liang Liu, Thomas S Hwang, David Huang
Purpose: To characterize the density and distribution of the radial peripapillary capillary plexus (RPCP) and its relationship with retinal nerve fiber layer (NFL) thickness in healthy subjects. Methods: Using spectral-domain optical coherence tomography (OCT), split-spectrum amplitude decorrelation angiography algorithm and automated montaging, wide-field OCT angiography (OCTA) was used to measure the RPCP capillary density (CD) and NFL thickness. Polar sector-average CD and thickness maps were also created on each eye...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29046363/serum-neurofilament-light-is-sensitive-to-active-cerebral-small-vessel-disease
#18
Thomas Gattringer, Daniela Pinter, Christian Enzinger, Thomas Seifert-Held, Markus Kneihsl, Simon Fandler, Alexander Pichler, Christian Barro, Svenya Gröbke, Margarete Voortman, Lukas Pirpamer, Edith Hofer, Stefan Ropele, Reinhold Schmidt, Jens Kuhle, Franz Fazekas, Michael Khalil
OBJECTIVE: To explore whether serum neurofilament light chain protein (NfL) levels are increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared to healthy controls and to determine the subsequent course and determinants of NfL levels in a longitudinal manner. METHODS: In a prospectively collected group of symptomatic patients with an RSSI (n = 79, mean age 61 ± 11 years, 67% male), we analyzed brain MRI and serum NfL using a Single Molecule Array (Simoa) assay at baseline and at 3 and 15 months after stroke...
October 18, 2017: Neurology
https://www.readbyqxmd.com/read/29041870/fluid-biomarker-and-electrophysiological-outcome-measures-for-progressive-ms-trials
#19
Christian Barro, Letizia Leocani, David Leppert, Giancarlo Comi, Ludwig Kappos, Jens Kuhle
Progressive multiple sclerosis (MS) is characterized by insidious clinical worsening that is difficult to accurately quantify and predict. Biofluid markers and electrophysiological measures are potential candidate outcome measures in clinical trials, allowing the quantification of nervous damage occurring in the disease. Neurofilaments are highly specific neuronal proteins. They may have come closest to such applications by their higher concentrations repeatedly demonstrated in cerebrospinal fluid (CSF) in all stages of MS, during relapses, their responsiveness to disease-modifying treatments in relapsing and progressive MS and their associations with measures of inflammatory and degenerative magnetic resonance imaging (MRI) outcomes...
October 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29023836/impact-of-nfl-play-60-programming-on-elementary-school-children-s-body-mass-index-and-aerobic-capacity-the-nfl-play-60-fitnessgram-partnership-project
#20
Pedro F Saint-Maurice, Yang Bai, Gregory J Welk, Lorraine N Bandelli, Kelly Allums-Featherston, Norma Candelaria
BACKGROUND: We examined the impact of the Fuel Up to Play 60 (FUTP60) program on children's body mass index (BMI) and aerobic capacity (AC). METHODS: Participation in the FUTP60 and both BMI and AC profiles were collected through the NFL PLAY 60 FitnessGram Partnership Project involving over 100 schools from 22 US states. We specifically examined the distributions of BMI and AC among participating versus nonparticipating schools in the 2012-2013 school year. Hierarchical linear models tested the impact of participation and availability of additional funding for program implementation on the proportions of youth meeting FitnessGram health-related fitness standards (ie, Needs Improvement-Health Risk [NIHR] and Healthy Fitness Zone [HFZ] categories)...
November 2017: Journal of School Health
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