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https://www.readbyqxmd.com/read/28203595/acute-gastrocnemius-soleus-complex-injuries-in-national-football-league-athletes
#1
Brian C Werner, Nicole S Belkin, Steve Kennelly, Leigh Weiss, Ronnie P Barnes, Hollis G Potter, Russell F Warren, Scott A Rodeo
BACKGROUND: Lower extremity muscle injuries are common in professional football. Although less common than hamstring or quadriceps injuries in National Football League (NFL) athletes, calf injuries occur with relative frequency and have not previously been studied. PURPOSE: To evaluate gastrocnemius-soleus complex muscle injuries over the past 13 years from a single NFL team to determine the incidence of such injuries, their imaging characteristics, and return to play after such injuries and any correlation between imaging findings and prolonged return to play...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28179466/blood-based-nfl-a-biomarker-for-differential-diagnosis-of-parkinsonian-disorder
#2
Oskar Hansson, Shorena Janelidze, Sara Hall, Nadia Magdalinou, Andrew J Lees, Ulf Andreasson, Niklas Norgren, Jan Linder, Lars Forsgren, Radu Constantinescu, Henrik Zetterberg, Kaj Blennow
OBJECTIVE: To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders. METHODS: The study included 3 independent prospective cohorts: the Lund (n = 278) and London (n = 117) cohorts, comprising healthy controls and patients with PD, progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), as well as an early disease cohort (n = 109) of patients with PD, PSP, MSA, or CBS with disease duration ≤3 years...
February 8, 2017: Neurology
https://www.readbyqxmd.com/read/28150426/reproducibility-and-repeatability-of-optical-coherence-tomography-imaging-of-the-optic-nerve-head-in-normal-beagle-eyes
#3
Alexandra M Bemis, Christopher G Pirie, Alexander J LoPinto, Louise Maranda
OBJECTIVE: To assess the reproducibility and repeatability of an optical coherence tomography (OCT) device for imaging the optic nerve region of normal canines. ANIMALS STUDIED: Twelve clinically healthy beagles. PROCEDURES: All animals were anesthetized, and an OCT device was used to image the optic disk region. Total disk area and retinal nerve fiber layer (NFL) thickness in eight segments were obtained from each image. Images were collected by two operators in succession and each operator took five scans, repositioning the device between measurements...
February 1, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28148632/serum-neurofilament-is-associated-with-progression-of-brain-atrophy-and-disability-in-early-ms
#4
Jens Kuhle, Bardia Nourbakhsh, Donna Grant, Steve Morant, Christian Barro, Özgür Yaldizli, Daniel Pelletier, Gavin Giovannoni, Emmanuelle Waubant, Sharmilee Gnanapavan
OBJECTIVE: To investigate a potential effect of riluzole on serum neurofilaments (Nf) compared to placebo and the relationship between longitudinal clinical and MRI outcomes and serum Nf levels. METHODS: Serum samples were obtained from participants enrolled in a randomized double-blind trial of neuroprotection with riluzole vs placebo as an add-on to weekly interferon-β (IFN-β)-1a IM initiated 3 months after randomization. Nf measurements were performed by ELISA and electrochemiluminescence immunoassay...
February 1, 2017: Neurology
https://www.readbyqxmd.com/read/28137618/astrocyte-neuron-interaction-in-diphenyl-ditelluride-toxicity-directed-to-the-cytoskeleton
#5
Luana Heimfarth, Fernanda da Silva Ferreira, Paula Pierozan, Moara Rodrigues Mingori, José Cláudio Fonseca Moreira, João Batista Teixeira da Rocha, Regina Pessoa-Pureur
Diphenylditelluride (PhTe)2 is a neurotoxin that disrupts cytoskeletal homeostasis. We are showing that different concentrations of (PhTe)2 caused hypophosphorylation of glial fibrillary acidic protein (GFAP), vimentin and neurofilament subunits (NFL, NFM and NFH) and altered actin organization in co-cultured astrocytes and neurons from cerebral cortex of rats. These mechanisms were mediated by N-methyl-d-aspartate (NMDA) receptors without participation of either L-type voltage-dependent calcium channels (L-VDCC) or metabotropic glutamate receptors...
January 27, 2017: Toxicology
https://www.readbyqxmd.com/read/28127735/effects-of-panretinal-laser-photocoagulation-on-the-corneal-nerve-plexus-and-retinal-nerve-fiber-layer-in-retinal-vein-occlusion
#6
Gulfidan Bitirgen, Selman Belviranli, Rayaz A Malik, Hurkan Kerimoglu, Ahmet Ozkagnici
PURPOSE: To determine the effects of panretinal photocoagulation (PRP) on corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with unilateral central retinal vein occlusion (CRVO) who had previously undergone PRP treatment. METHODS: Sixty-four eyes of 32 patients (19 male, 13 female) with unilateral ischemic type CRVO who had undergone PRP treatment at least 6 months previously were included in this cross-sectional study...
January 23, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28109942/effect-of-pulmonary-rehabilitation-on-tidal-expiratory-flow-limitation-at-rest-and-during-exercise-in-copd-patients
#7
Elpida P Theodorakopoulou, Sofia-Antiopi Gennimata, Maria Harikiopoulou, Georgios Kaltsakas, Anastasios Palamidas, Antonia Koutsoukou, Charis Roussos, Epameinondas N Kosmas, Petros Bakakos, Nickolaos G Koulouris
We hypothesized that severe COPD patients who present with the disadvantageous phenomenon of Expiratory Flow Limitation (EFL) may benefit as COPD patients without EFL do after implementation of a Pulmonary Rehabilitation (PR) program. Forty-two stable COPD patients were studied at rest and during exercise. EFL and dynamic hyperinflation (DH) were documented using the negative expiratory pressure (NEP) technique and inspiratory capacity (IC) maneuvers, respectively. Patient centered outcomes were evaluated by the Saint-George's Respiratory Questionnaire (SGRQ) and the mMRC dyspnea scale...
January 18, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28099960/prognostic-factors-after-curative-resection-for-single-lesion-hepatocellular-carcinoma-in-patients-with-normal-liver-function-a-historical-cohort-study
#8
Mitsugi Shimoda, Kazuma Tago, Masato Kato, Taku Aoki, Keiichi Kubota
BACKGROUND: Hepatic resection for hepatocellular carcinoma (HCC) is now established as the treatment most likely to yield the best outcome. We aimed to clarify the risk factors for HCC recurrence after curative resection of single HCC in patients with normal liver function (NLF). METHODS: The clinical records of 105 patients with NFL and a single HCC less than 5 cm in diameter who had undergone curative liver resection between April 2000 and January 2013 were investigated...
January 19, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28095549/treatment-of-facial-photodamage-with-mass-market-topical-products-vs-non-ablative-fractional-laser
#9
Hilary Reich, Irmina Wallander, Lacie Schulte, Molly Goodier, Brian Zelickson
METHODS: In this split-face, evaluator-blinded study, 18 subjects were randomly assigned to receive either the SSR or NFL treatments on each side of the face. For the SSR facial sides subjects followed two morning-evening regimens. On the NFL sides subjects were treated 3 times with the 1927-nm laser at 4-week intervals. Three physician evaluators were asked to rate hyperpigmentation, global photoaging, and ne lines and wrinkles for each side of the face at baseline and at 3 months using a 5-point scale...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095082/effect-of-concussion-on-performance-of-national-football-league-players
#10
Nicole Reams, Rodney A Hayward, Jeffrey S Kutcher, James F Burke
PURPOSE: Lingering neurologic injury after concussion may expose athletes to increased risk if return-to-play is premature. We explored whether on-field performance after concussion is a marker of lingering neurologic injury. METHODS: Retrospective cohort study on 1,882 skill-position players who played in the National Football League (NFL) during 2007-2010. Players with concussion based on the weekly injury report, were compared to players with other head and neck injuries (controls) on measures of on-field performance using Football Outsiders' calculation of Defense-Adjusted Yards Above Replacement (DYAR): a measure of a player's contribution controlling for game context...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28056179/descriptive-characteristics-of-concussions-in-national-football-league-games-2010-2011-to-2013-2014
#11
Michael D Clark, Breton M Asken, Stephen W Marshall, Kevin M Guskiewicz
BACKGROUND: Despite a high reported incidence rate of concussion, little is known about the on-field characteristics of injurious head impacts in National Football League (NFL) games. PURPOSE: To characterize on-field features (location, player position, and time during game) and biomechanical features (anticipation status, closing distance, impact location and type) associated with concussions in NFL games over a 4-season period (2010-2011 to 2013-2014). STUDY DESIGN: Descriptive epidemiology study...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28052052/physical-characteristics-and-performance-of-japanese-top-level-american-football-players
#12
Daichi Yamashita, Masaki Asakura, Yoshihiko Ito, Shinzo Yamada, Yosuke Yamada
This study aimed to compare the physical characteristics and performance between top-level non-professional football players in Japan and National Football League (NFL) Combine invited players and between top- and middle-level players in Japan in order to determine the factors that enhance performance in international and national competitions. One hundred sixty-eight American football players (>20 years) in Japan participated in an anthropometric (height and weight) and physical (vertical jump, long jump, 40-yard dash, pro-agility shuttle, three-cone drill, and bench press repetition test) measurement program based on the NFL Combine program to compete in the selection of candidates for the Senior World Championship...
November 5, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28046096/early-antiretroviral-therapy-is-associated-with-lower-hiv-dna-molecular-diversity-and-lower-inflammation-in-cerebrospinal-fluid-but-does-not-prevent-the-establishment-of-compartmentalized-hiv-dna-populations
#13
Michelli F Oliveira, Antoine Chaillon, Masato Nakazawa, Milenka Vargas, Scott L Letendre, Matthew C Strain, Ronald J Ellis, Sheldon Morris, Susan J Little, Davey M Smith, Sara Gianella
Even when antiretroviral therapy (ART) is started early after infection, HIV DNA might persist in the central nervous system (CNS), possibly contributing to inflammation, brain damage and neurocognitive impairment. Paired blood and cerebrospinal fluid (CSF) were collected from 16 HIV-infected individuals on suppressive ART: 9 participants started ART <4 months of the estimated date of infection (EDI) ("early ART"), and 7 participants started ART >14 months after EDI ("late ART"). For each participant, neurocognitive functioning was measured by Global Deficit Score (GDS)...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28032805/nerve-fiber-layer-thickness-and-characteristics-associated-with-glaucoma-in-community-living-older-adults-prelude-to-a-screening-trial
#14
Barbara E K Klein, Chris A Johnson, Stacy M Meuer, Kyungmoo Lee, Andreas Wahle, Kristine E Lee, Amruta Kulkarni, Milan Sonka, Michael D Abràmoff, Ronald Klein
PURPOSE: To examine the associations of nerve fiber layer (NFL) thickness with other ocular characteristics in older adults. METHODS: Participants in the Beaver Dam Eye Study (2008-2010) underwent spectral domain optical coherence tomography (SD-OCT) scans of the optic nerve head, imaging of optic discs, frequency doubling technology (FDT) perimetry, measurement of intraocular pressure (IOP), and an interview concerning their history of glaucoma and use of drops to lower eye pressure...
December 29, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28011613/spinal-arachnoiditis-as-a-complication-of-cryptococcal-meningoencephalitis-in-non-hiv-previously-healthy-adults
#15
Anil A Panackal, Mika Komori, Peter Kosa, Omar Khan, Dima A Hammoud, Lindsey B Rosen, Sarah K Browne, Yen-Chih Lin, Elena Romm, Charu Ramaprasad, Bettina C Fries, John E Bennett, Bibiana Bielekova, Peter R Williamson
BACKGROUND: Cryptococcus can cause meningoencephalitis (CM) among previously healthy non-HIV adults. Spinal arachnoiditis is under-recognized, since diagnosis is difficult with concomitant central nervous system (CNS) pathology. METHODS: We describe 6 cases of spinal arachnoiditis among 26 consecutively recruited CM patients with normal CD4 counts who achieved microbiologic control. We performed detailed neurological exams, cerebrospinal fluid (CSF) immunophenotyping and biomarker analysis before and after adjunctive immunomodulatory intervention with high dose pulse corticosteroids, affording causal inference into pathophysiology...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28005971/the-anatomy-of-american-football-evidence-from-7-years-of-nfl-game-data
#16
Konstantinos Pelechrinis, Evangelos Papalexakis
How much does a fumble affect the probability of winning an American football game? How balanced should your offense be in order to increase the probability of winning by 10%? These are questions for which the coaching staff of National Football League teams have a clear qualitative answer. Turnovers are costly; turn the ball over several times and you will certainly lose. Nevertheless, what does "several" mean? How "certain" is certainly? In this study, we collected play-by-play data from the past 7 NFL seasons, i...
2016: PloS One
https://www.readbyqxmd.com/read/28005675/swept-source-optical-coherence-tomography-angiography-of-the-optic-disk-in-optic-neuropathy
#17
Khalil Ghasemi Falavarjani, Jack J Tian, Handan Akil, Giancarlo A Garcia, Srinivas R Sadda, Alfredo A Sadun
PURPOSE: To evaluate the optic nerve head microvasculature in eyes with acute and chronic optic neuropathies using swept-source optical coherence tomography angiography. METHODS: In this cross-sectional, observational study, optical coherence tomography angiography images were obtained from the optic nerve heads of 21 eyes of 12 patients with optic disk edema, pseudoedema and atrophy, and 12 eyes of 6 healthy subjects using a 1,050-nm optical coherence tomography angiography (Topcon DRI OCT; Triton)...
December 2016: Retina
https://www.readbyqxmd.com/read/28000086/interaction-of-small-heat-shock-proteins-with-light-component-of-neurofilaments-nfl
#18
Victoria V Nefedova, Maria V Sudnitsyna, Nikolai B Gusev
The interaction of human small heat shock protein HspB1, its point mutants associated with distal hereditary motor neuropathy, and three other small heat shock proteins (HspB5, HspB6, HspB8) with the light component of neurofilaments (NFL) was analyzed by differential centrifugation, analytical ultracentrifugation, and fluorescent spectroscopy. The wild-type HspB1 decreased the quantity of NFL in pellets obtained after low- and high-speed centrifugation and increased the quantity of NFL remaining in the supernatant after high-speed centrifugation...
December 20, 2016: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/27996900/tbi-and-nfl-culture-can-players-autonomously-refuse-biometric-monitoring
#19
Paul Cummins
No abstract text is available yet for this article.
January 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/27996330/suicide-in-professional-american-football-players-in-the-past-95-years
#20
David Webner, Grant L Iverson
OBJECTIVE: To examine publicly-available information on all identified cases of suicide in active or former American professional football players between 1920 and the spring of 2015. DESIGN: Retrospective cohort study. SETTING: Professional American Football in the US. PARTICIPANTS: A cohort of 26 702 athletes who had died, retired or were currently playing in the NFL from nfl.com since 1920 was identified. MAIN OUTCOME MEASURES: Internet queries identifying 26 professional football players who completed suicide...
2016: Brain Injury: [BI]
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