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infiltrating ductal carcinoma

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https://www.readbyqxmd.com/read/29658333/mucinous-breast-carcinoma-with-tall-columnar-cells
#1
N Tsoukalas, M Kiakou, M Tolia, I D Kostakis, M Galanopoulos, G Nakos, D Tryfonopoulos, G Kyrgias, G Koumakis
Mucinous carcinoma of the breast represents 1%-4% of all breast cancers. The World Health Organization classification divides this type of tumour into three different subtypes: mucinous carcinoma, mucinous carcinoma with tall columnar cells (mucinous cystadenocarcinoma and columnar cell mucinous carcinoma) and signet ring cell carcinoma. A 74-year-old woman presented a tumour with inflammatory features in the upper outer quadrant of her left breast, 7 cm in diameter. The core biopsy showed infiltrating ductal carcinoma of no specific type...
April 16, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29645079/antinuclear-antibodies-in-patients-with-breast-cancer
#2
Renato Nisihara, Mariana C C Machoski, Aline Neppel, Carlos A Maestri, Iara Messias-Reason, Thelma L Skare
PURPOSE: To study the prevalence of ANA in breast cancer patients and its association with tumor characteristics. METHODS: Ninety one patients with breast mass detected by image studies and assigned to do diagnostic biopsy and eventual surgical treatment were studied for demographical, tumor data and presence of ANA. Serum of positive ANA patients was screened for ENA (extractable nuclear antigens) profile. As comparison, 91 healthy individuals matched for age and from same geographical area were included...
April 12, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29643909/hyperlipidemia-and-hyper-glycaemia-in-breast-cancer-patients-is-related-to-disease-stage
#3
Uzma Raza, Mahay Rookh Asif, Asif Bin Rehman, Aminuddin Sheikh
Objective: The study was designed to determine the hyperlipidemia in breast cancer of patients at disease presentation, without any treatment and to correlate these variations with disease stage. Methods: This cross sectional study was conducted at Liaquat National teaching hospital in Karachi from 2006 to 2011, Age and family history of 208 breast cancer patients with infiltrating Ductal Carcinoma were compared with 176 matched control subjects. Married females were selected, with children and short breast feeding period...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29623677/population-based-study-of-the-sensitivity-of-axillary-ultrasound-imaging-in-the-preoperative-staging-of-node-positive-invasive-lobular-carcinoma-of-the-breast
#4
E Morrow, A Lannigan, J Doughty, J Litherland, J Mansell, S Stallard, E Mallon, L Romics
BACKGROUND: Preoperative staging of the axilla is important to allow decisions regarding neoadjuvant treatment and the management of the axilla. Invasive lobular carcinoma metastases are difficult to detect because of the infiltrative pattern of the nodal spread. In this study the sensitivity of preoperative axillary staging between invasive lobular (ILC) and ductal (IDC) carcinoma was compared. METHODS: All women diagnosed with pure ILC or IDC in the West of Scotland in 2012-2014 were identified from a database maintained prospectively within the Managed Clinical Network...
April 5, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29567882/immunohistochemical-evaluation-of-lymphovascular-invasion-in-carcinoma-breast-with-cd34-and-d2-40-and-its-correlation-with-other-prognostic-markers
#5
Sonal Agarwal, Amarjit Singh, Permeet Kaur Bagga
Background: Carcinoma breast is ever-evolving and becoming increasingly prevalent in India. Numerous prognostic factors based on morphology and immunohistochemistry (IHC) have been established which need to be interconnected to give patients best possible treatment. Aims: This study aims to confirm and analyze lymphovascular invasion (LVI) detected by hematoxylin and eosin (H and E) using IHC with CD34 and D2-40 and its correlation with other biologic and morphologic prognostic markers...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29566940/breast-carcinoma-with-osteoclast-like-giant-cells-a-cytological-pathological-correlation-with-a-literature-review
#6
Ryuji Ohashi, Ayako Hayama, Miyuki Matsubara, Yasuhiko Watarai, Takashi Sakatani, Zenya Naito, Akira Shimizu
Breast carcinoma with osteoclast-like giant cells (OGCs) is a rare disease characterized by the infiltration of OGCs in the tumor; however, cytological aspects of this tumor type remain elusive. We examined the cytological features in fine needle aspiration (FNA) biopsy smears obtained from 5 patients who were histologically diagnosed with breast carcinoma with OGCs. We compared FNA and clinicopathological findings with results from the published literature. Histological assessment of the resected samples showed that all tumors exhibited a histological grade 1 phenotype with a predominant cribriform architecture...
April 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29559742/prognostic-significance-of-tumor-infiltrating-lymphocytes-in-ductal-carcinoma-in-situ-of-the-breast
#7
Michael S Toss, I Miligy, Abdubaqi Al-Kawaz, Mansour Alsleem, Hazem Khout, Padmashree C Rida, Ritu Aneja, Andrew R Green, Ian O Ellis, Emad A Rakha
Tumor-infiltrating lymphocytes (TILs) provide prognostic value in invasive breast cancer and guidelines for their assessment have been published. This study aims to evaluate: (a) methods of TILs assessment, and (b) their prognostic significance in breast ductal carcinoma in situ (DCIS). Hematoxylin and eosin sections from two clinically annotated DCIS cohorts; a training set (n = 150 pure DCIS) and a validation set (n = 666 comprising 534 pure DCIS and 132 cases wherein DCIS and invasive breast carcinoma were co-existent) were assessed...
March 20, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29527326/a-phantom-study-of-terahertz-spectroscopy-and-imaging-of-micro-and-nano-diamonds-and-nano-onions-as-contrast-agents-for-breast-cancer
#8
Tyler Bowman, Alec Walter, Olga Shenderova, Nicholas Nunn, Gary McGuire, Magda El-Shenawee
THz imaging is effective in distinguishing between cancerous, healthy, and fatty tissues in breast tumors, but a challenge remains in the contrast between cancerous and fibroglandular (healthy) tissues. This work investigates carbon-based nanoparticles as potential contrast agents for terahertz imaging of breast cancer. Microdiamonds, nanodiamonds, and nanometer-scale onion-like carbon are characterized with terahertz transmission spectroscopy in low-absorption backgrounds of polydimethylsiloxane or polyethylene...
October 2017: Biomedical Physics & Engineering Express
https://www.readbyqxmd.com/read/29492715/mast-cells-and-angiogenesis-in-pancreatic-ductal-adenocarcinoma
#9
REVIEW
Vito Longo, Roberto Tamma, Oronzo Brunetti, Salvatore Pisconti, Antonella Argentiero, Nicola Silvestris, Domenico Ribatti
Mast cells are recognized as critical components of the tumor stromal microenvironment in several solid and hematological malignancies, promoting angiogenesis and tumor growth. A correlation between mast cells infiltration, angiogenesis and tumor progression has been reported for pancreatic ductal adenocarcinoma as well. Mast cells contribute to the aggressiveness of the pancreatic ductal carcinoma enhancing the expression of several pro-angiogenic factors such as vascular endothelial growth factor, fibroblast growth factor-2, platelet-derived growth factor and angiopoietin-1 as well as stimulating the pancreatic cancer cells proliferation by IL-13 and tryptase...
February 28, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29491608/polymorphous-adenocarcinoma-of-the-oral-cavity-a-skeptical-case-mimicking-lobular-carcinoma-of-breast-and-gastric-carcinoma
#10
Purnima Vadla, Sankeerthana Pathipaka, Jayakiran Madala, Venkateswara Rao Guttikonda
Polymorphous adenocarcinoma (PAC) is a distinctive salivary gland neoplasm that predominantly occurs in the minor salivary glands. The tumor is characterized by cytological uniformity, morphological diversity, an infiltrative growth pattern and low metastatic potential. It presents as an asymptomatic, slow- growing mass within the oral cavity. This salivary gland tumor is difficult to diagnose both clinically and histopathologically due to its indolent presentation and diverse architectural pattern which includes various microscopic patterns namely- solid, ductal-tubular, cribriform, trabecular and single-file growth...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29480844/solitary-duodenum-metastasis-from-breast-cancer-with-8-years-latency-a-case-report
#11
Xuan Wang, Min Jin, Qingqing Ye, Meng Wang, Yan Hu, Yonghua Yang, Jiyuan Yang, Jun Cai
RATIONALE: Advanced breast cancer frequently metastasizes to the lungs, liver, and bones. Metastatic involvement of the duodenal bulb is extremely rare and difficult to detect by endoscopy. PATIENT CONCERNS: A 51-year-old menopausal woman presented with abdominal fullness and obstructive symptoms, and was diagnosed with adenocarcinoma in the duodenal bulb. The patient had undergone modified radical mastectomy of the left breast for infiltrating ductal carcinoma (IDC) 8 years previously...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29470686/a-case-of-stage-ia-pancreatic-ductal-adenocarcinoma-accompanied-with-focal-pancreatitis-demonstrated-by-contrast-enhanced-ultrasonography
#12
Junko Fukuda, Sachiko Tanaka, Nobuko Ishida, Tatsuya Ioka, Kenji Ikezawa, Rena Takakura, Miho Nakao, Kazuyoshi Ohkawa, Kazuhiro Katayama, Shigenori Nagata
A patient with slight dilatation of the main pancreatic duct was followed-up with ultrasonography every 6 months as a high-risk case of pancreatic cancer. Twelve years later, a faint hypoechoic area 13 mm in diameter was first detected on the body of the pancreas. Contrast-enhanced ultrasonography revealed a well-demarcated hypoenhanced area 8 mm in diameter and a hyperenhanced area with an unclear margin. The former was suspected to be a small pancreatic cancer lesion, and the latter to be focal pancreatitis accompanying cancer...
February 22, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29463884/tumor-infiltrating-lymphocytes-and-ductal-carcinoma-in-situ-of-the-breast-friends-or-foes
#13
REVIEW
Marie Colombe Agahozo, Dora Hammerl, Reno Debets, Marleen Kok, Carolien H M van Deurzen
In the past three decades, the detection rate of ductal carcinoma in situ of the breast has dramatically increased due to breast screening programs. As a consequence, about 20% of all breast cancer cases are detected in this early in situ stage. Some ductal carcinoma in situ cases will progress to invasive breast cancer, while other cases are likely to have an indolent biological behavior. The presence of tumor-infiltrating lymphocytes is seen as a promising prognostic and predictive marker in invasive breast cancer, mainly in HER2-positive and triple-negative subtypes...
February 20, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29403165/micronucleus-study-on-breast-cytology-aspirate-smears-and-its-diagnostic-utility
#14
Mary T Sylvia, Lavanya Baskaran, Ramachandra V Bhat
Background: Micronucleus is a small fragment of nucleus present in the cells which have undergone chromosomal damage. It is used as a biomarker of genomic damage. Aims: We aim to study the presence of micronucleus on breast cytology smears and the use of scoring the micronucleus as an additional criteria for the classification of breast lesions with emphasis on borderline gray zone categories. Settings and Design: This is a cross-sectional retrospective descriptive study...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29402546/reconstruction-of-an-anterior-chest-wall-radionecrosis-defect-by-a-contralateral-latissimus-dorsi-flap-a-case-report
#15
A Vairinho, A Al Hindi, M Revol, A Legras, K Rem, Y Guenane, S Cristofari, T Sorin
INTRODUCTION: Soft tissue and bone radionecrosis are rare but serious complications may occur late after radiotherapy. CASE REPORT: We report the case of an 86-year-old woman with a history an infiltrating ductal carcinoma of the left breast, treated by total mastectomy, left axillary dissection and adjuvant radiotherapy. Eighteen years later, the first radionecrosis lesions appeared and grew progressively in a 6-month period. These lesions are deep, involving the anterior aspect of the 4th to the 6th ribs and infiltrating the chest wall to the left cardio-thoracic space communicating largely with the pericardium...
February 2, 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29394917/analysis-of-tumour-infiltrating-lymphocytes-reveals-two-new-biologically-different-subgroups-of-breast-ductal-carcinoma-in-situ
#16
Marie Beguinot, Marie-Melanie Dauplat, Fabrice Kwiatkowski, Guillaume Lebouedec, Lucie Tixier, Christophe Pomel, Frederique Penault-Llorca, Nina Radosevic-Robin
BACKGROUND: Tumour-infiltrating lymphocytes (TILs) have been demonstrated to significantly influence prognosis and response to therapy of invasive breast cancer (IBC). Thus, it has been suggested that TIL density or/and immunophenotype could serve as biomarkers for selection of IBC patients for immunotherapy. However, much less is known about significance of TILs in breast ductal carcinoma in situ (DCIS). METHODS: We retrospectively investigated TIL density and immunophenotype in 96 pure DCIS and 35 microinvasive carcinomas (miCa)...
February 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29390502/male-occult-breast-cancer-with-axillary-lymph-node-metastasis-as-the-first-manifestation-a-case-report-and-literature-review
#17
REVIEW
Ruixin Xu, Jianbin Li, Yingjie Zhang, Hongbiao Jing, Youzhe Zhu
RATIONALE: Occult breast cancer (OBC) is extremely rare in males with neither symptoms in the breast nor abnormalities upon imaging examination. PATIENT CONCERNS: This current case report presents a young male patient who was diagnosed with male OBC first manifesting as axillary lymph node metastasis. The physical and imaging examination showed no primary lesions in either breasts or in other organs. DIAGNOSES: The pathological results revealed infiltrating ductal carcinoma in the axillary lymph nodes...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383131/development-of-a-reliable-and-accurate-algorithm-to-quantify-the-tumor-immune-stroma-qtis-across-tumor-types
#18
Rainer Christoph Miksch, Jingcheng Hao, Markus Bo Schoenberg, Katharina Dötzer, Friederike Schlüter, Maximilian Weniger, Shuai Yin, Steffen Ormanns, Jan Goesta D'Haese, Markus Otto Guba, Jens Werner, Barbara Mayer, Alexandr V Bazhin
The tumor microenvironment plays an important role in the tumor biology. Overall survival of tumor patients after resection is influenced by tumor-infiltrating lymphocytes (TILs) as a component of the tumor stroma. However, it is not clear how to assess TILs in the tumor stroma due to heterogeneous methods in different cancer types. Therefore, we present a novel Quantification of the Tumor immune Stroma (QTiS) Algorithm to reliably and accurately quantify cells in the tumor stroma. Immunohistochemical staining of CD3 and CD8 cells in sections of metastatic colorectal cancer (mCRC), ovarian cancer (OvCa), hepatocellular carcinoma (HCC), and pancreatic ductal adenocarcinoma (PDAC), alltogether N = 80, was performed...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29344276/the-clinicopathological-features-and-survival-outcomes-of-different-histological-subtypes-in-triple-negative-breast-cancer
#19
Hong-Ye Liao, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, San-Gang Wu
Purpose: To determine the clinicopathological features and survival outcomes of triple-negative breast cancer (TNBC) according to different histological subtypes. Methods: Using the Surveillance, Epidemiology, and End Results database, we included TNBC cases in 2010-2013. The effect of histological subtype on breast cancer-specific survival (BCSS) and overall survival (OS) were analyzed using univariate and multivariate analyses. Results: A total of 19,900 patients were identified. Infiltrating ductal carcinoma not otherwise specified accounted for 91...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29336321/epstein-barr-virus-and-invasive-mammary-carcinomas-ebna-ebers-and-molecular-profile-in-a-population-of-west-algeria
#20
Radia Yahia, Chahinez Zaoui, Wafaa Derbale, Hafsa Boudi, Yahia Chebloune, Tewfik Sahraoui, Fatima Zohra Elkebir
Breast cancer is the common malignancy that affects women worldwide, but conventional risk factors account for only a small proportion of these cases. A possible viral etiology for breast cancer has been proposed and Epstein-Barr virus (EBV) is a widely studied candidate virus. The objective of this study is to determine the association of EBV infection with infiltrating ductal carcinomas (IDC). This descriptive study was carried out in the laboratory of developmental biology and differentiation, from 2012 to 2014...
January 1, 2018: Annales de Biologie Clinique
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