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https://www.readbyqxmd.com/read/29164600/18f-pet-with-florbetaben-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#1
REVIEW
Gabriel Martínez, Robin Wm Vernooij, Paulina Fuentes Padilla, Javier Zamora, Leon Flicker, Xavier Bonfill Cosp
BACKGROUND: (18)F-florbetaben uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using some amyloid biomarkers tests like (18)F-florbetaben...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29159767/development-and-validation-of-the-health-of-the-nation-outcome-scales-residential-facility-honos-rf
#2
Laura Pedrini, Mariangela Lanfredi, Clarissa Ferrari, Sonia Andreose, Pasquale Basso, Rossella Beneduce, Rosaria Pioli, Luciana Rillosi, Giuseppe Rossi, Roberta Rossi, Giovanni Battista Tura
The Health of the Nation Outcome Scale (HoNOS) (Lora et al. Epidemiol Psichiatr Soc 10(3):198-212, 2001) is widely used. However, clinicians have expressed concerns about its ability to describe severe mentally ill patients, as it does not consider some relevant clinical aspects. This study aims to develop and validate the HoNOS-Residential Facility (HoNOS-RF) in order to pursue a thorough assessment of patients admitted to psychiatric residential facilities (RFs). The final version of the HoNOS-RF was administered to 409 patients admitted to four RFs...
November 21, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29157745/differential-diagnosis-of-parkinsonian-syndromes-using-dopamine-transporter-and-perfusion-spect
#3
Shigetoshi Takaya, Nobukatsu Sawamoto, Tomohisa Okada, Gosuke Okubo, Sei Nishida, Kaori Togashi, Hidenao Fukuyama, Ryosuke Takahashi
OBJECTIVE: We aimed to assess whether a combined analysis of dopamine transporter (DAT)- and perfusion-SPECT images (or either) could: (1) distinguish atypical parkinsonian syndromes (APS) from Lewy body diseases (LBD; majority Parkinson disease [PD]), and (2) differentiate among APS subgroups (progressive supranuclear palsy [PSP], corticobasal syndrome [CBS], and multiple system atrophy [MSA]). METHODS: We recruited consecutive patients with neurodegenerative parkinsonian syndromes (LBD, n = 46; APS, n = 33)...
November 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29155978/results-of-repeated-video-assisted-thoracic-surgery-for-recurrent-pneumothorax-after-primary-spontaneous-pneumothorax
#4
Sukki Cho, Sanghoon Jheon, Dong Kwan Kim, Hyeong Ryul Kim, Dong Myung Huh, Sungsoo Lee, Kyoung Min Ryu, Deog Gon Cho
OBJECTIVES: This study aimed to identify the causes of recurrent pneumothorax and to evaluate the results of repeated video-assisted thoracic surgery (VATS) for recurrent pneumothorax after VATS wedge resection for primary spontaneous pneumothorax (PSP). METHODS: A retrospective review was conducted on 188 patients with recurrent PSP, of a population of 1414 patients who underwent VATS wedge resection for PSP. Reoperations were performed when an air leak persisted longer than 3 days after closed thoracostomy, when a visible bulla of greater than 1 cm on high-resolution computed tomography (HRCT) was observed and when rerecurrence took place after other treatments...
November 16, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29150129/diagnostic-accuracy-of-4-intraoral-radiographic-techniques-for-misfit-detection-at-the-implant-abutment-joint
#5
Pollyana Darós, Vinícius Cavalcanti Carneiro, Amanda Pasolini Siqueira, Sergio Lins de-Azevedo-Vaz
STATEMENT OF PROBLEM: A misfit or gap at the implant-abutment joint (IAJ) requires detection as it may compromise the health of the peri-implant tissue. However, which radiographic technique provides the most orthogonal relationship between the central beam and the implant/image receptor is unclear. PURPOSE: The purpose of this in vitro study was to evaluate the diagnostic accuracy of 4 intraoral radiographic techniques on misfit detection at the IAJ. MATERIAL AND METHODS: Twenty implants were placed in polyamide jaws, and customized dental implant abutments with a metal collar were installed...
November 15, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29146176/neosaxitoxin-a-paralytic-shellfish-poison-toxin-effectively-manages-bucked-shins-pain-as-a-local-long-acting-pain-blocker-in-an-equine-model
#6
Gricel Riquelme, Joaquín M Sepúlveda, Zaki Al Ghumgham, Miguel Del Campo, Cecilia Montero, Nestor Lagos
Local anesthesia is an effective method to control pain. Neosaxitoxin is a phycotoxin whose molecular mechanism includes a reversible inhibition of voltage-gated sodium channels at the axonal level, impeding nerve impulse propagation. The present study was designed to evaluate the clinical efficacy of Neosaxitoxin as a local long-acting pain blocker in horse bucked shins, and it was found to effectively control pain. While Neosaxitoxin and Gonyautoxin, another Paralytic Shellfish Poison (PSP) toxin, have been successfully used in humans as long-lasting pain blockers, this finding marks the first time a PSP has been shown to have an established effect in veterinary medicine...
November 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29145846/comparison-of-diagnostic-methods-for-early-interproximal-caries-detection-with-near-infrared-light-transillumination-an-in-vivo-study
#7
Ismail Hakki Baltacioglu, Kaan Orhan
BACKGROUND: Although numerous studies have used digital intraoral imaging, only a few studies have used photo-optical methods for the diagnosis of caries. Moreover, several limitations exist in terms of observers (experience and specialty) and the caries lesion itself. Hence, the aims of this study were to evaluate the diagnostic capability of near-infrared light transillumination (NILT) and PSP-Bitewing radiographs and to compare the interobserver and intraobserver differences in addition to observers' experience level to detect early interproximal caries lesions in vivo...
November 16, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29140686/the-regulatory-mechanism-of-mycobacterium-tuberculosis-phosphoserine-phosphatase-serb2
#8
Gregory A Grant
Almost all organisms contain the same biosynthetic pathway for the synthesis of l-serine from the glycolytic intermediate, D-3-phosphoglycerate. However, regulation of this pathway varies from organism to organism. Many organisms control the activity of the first enzyme in the pathway, D-3-phosphoglyerate dehydrogenase (PGDH), by feedback inhibition through the interaction of l-serine with the ACT domains within the enzyme. The last enzyme in the pathway, phosphoserine phosphatase (PSP) has also been reported to be inhibited by l-serine...
November 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29137817/beyond-als-and-ftd-the-phenotypic-spectrum-of-tbk1-mutations-includes-psp-like-and-cerebellar-phenotypes
#9
Carlo Wilke, Jonathan Baets, Jan L De Bleecker, Tine Deconinck, Saskia Biskup, Stefanie N Hayer, Stephan Züchner, Rebecca Schüle, Peter De Jonghe, Matthis Synofzik
Mutations in the TANK-binding kinase 1 gene (TBK1) are a rare, but recurrent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, the complete phenotypic spectrum of syndromes associated with TBK1 mutations remains to be elucidated. Using next-generation panel-sequencing of neurodegenerative disease genes, we identified a TBK1 index patient presenting with a progressive supranuclear palsy-like syndrome. Consecutively, we screened the whole-exome sequencing data of 439 index subjects presenting with various neurodegenerative syndromes outside the ALS-FTD spectrum for TBK1 mutations...
October 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29126761/mr-planimetry-in-neurodegenerative-parkinsonism-yields-high-diagnostic-accuracy-for-psp
#10
Stephanie Mangesius, Anna Hussl, Florian Krismer, Philipp Mahlknecht, Eva Reiter, Susanne Tagwercher, Atbin Djamshidian, Michael Schocke, Regina Esterhammer, Gregor Wenning, Christoph Müller, Christoph Scherfler, Elke R Gizewski, Werner Poewe, Klaus Seppi
INTRODUCTION: Several previous studies examined different brainstem-derived MR planimetric measures with regards to their diagnostic accuracy in separating patients with neurodegenerative parkinsonian disorders and reported conflicting results. The current study aimed to compare their performance in a well-characterized sample of patients with neurodegenerative parkinsonian disorders. METHODS: MR planimetric measurements were assessed in a large retrospective cohort of 55 progressive supranuclear palsy (PSP), 194 Parkinson's disease (PD) and 63 multiple system atrophy (MSA) patients...
October 31, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29118735/divergent-thinking-in-parkinsonism-a-case-control-study
#11
Margherita Canesi, Maria Luisa Rusconi, Emanuele Cereda, Alessandra Ranghetti, Viviana Cereda, Federica Moroni, Gianni Pezzoli
Background: Creativity is a multidimensional phenomenon and an important component of human capacities. This ability is characterized by the involvement of several cognitive functions particularly linked to the prefrontal cortex. We compared divergent thinking, a measure of creativity, in patients affected by progressive supranuclear palsy (PSP), other parkinsonian syndromes, and healthy controls (HCs). Methods: Creativity features were evaluated using the Abbreviated Torrance Test for Adults (ATTA)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29114382/the-inhibitory-effects-of-polysaccharide-peptides-psp-of-ganoderma-lucidum-against-atherosclerosis-in-rats-with-dyslipidemia
#12
Titin Andri Wihastuti, Teuku Heriansyah
Background: Atherosclerosis occurs as a result of low-density lipoprotein (LDL) deposits oxidation. Endothelial dysfunction is an early process of atherosclerosis. Restoring endothelial lining back to normal by endothelial progenitor cells (EPCs) is critical for slowing or reversing vascular disease progression. Oxidative stress from hydrogen peroxide (H2O2) is increased in dyslipidemia so that antioxidant agent is required to prevent destruction of blood vessels. Objectives: This study aims to report Ganoderma lucidum polysaccharide peptide (PsP) effects in atherogenic process by measuring H2O2 level, IL-10 level, and EPC number in blood serum, and also intima-media thickness of aorta in dyslipidemia Wistar rat model by giving them a hypercholesterol diet (HCD)...
January 2017: Heart International
https://www.readbyqxmd.com/read/29113357/brain-gray-matter-abnormalities-in-progressive-supranuclear-palsy-revisited
#13
PingLei Pan, Yi Liu, Yang Zhang, Hui Zhao, Xing Ye, Yun Xu
Whole-brain voxel-based morphometry (VBM) studies of progressive supranuclear palsy (PSP) have demonstrated heterogeneous findings regarding gray matter (GM) abnormalities. Here, we used Seed-based d Mapping, a coordinate-based meta-analytic approach to identify consistent regions of GM anomalies across studies of PSP. Totally, 18 original VBM studies, comprising 284 patients with PSP and 367 healthy controls were included. As compared to healthy controls, patients with PSP demonstrated significant GM reductions in both cortical and subcortical regions, including the frontal motor cortices, medial (including anterior cingulate cortex) and lateral frontal cortices, insula, superior temporal gyrus, striatum (putamen and caudate nucleus), thalamus, midbrain, and anterior cerebellum...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29111028/csf-biomarkers-%C3%AE-amyloid-tau-proteins-and-a-synuclein-in-the-differential-diagnosis-of-parkinson-plus-syndromes
#14
Vasilios C Constantinides, George P Paraskevas, Evangelia Emmanouilidou, Olga Petropoulou, Anastasia Bougea, Kostas Vekrellis, Ioannis Evdokimidis, Eleftherios Stamboulis, Elisabeth Kapaki
INTRODUCTION: Differential diagnosis of Parkinson-plus patients (PSP, CBD, MSA) and Parkinson's disease (PD) patients is often not straightforward, particularly in atypical cases or at the initial stages of the diseases. Classic CSF biomarkers (amyloid-beta - Aβ42, tau protein - τT and phosphorylated tau protein - τP-181) are established biomarkers in the diagnosis of Alzheimer's disease (AD). CSF a-synuclein (α-syn) has emerged as a promising biomarker in patients with Parkinsonism...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29111000/natural-history-and-predictors-of-survival-in-progressive-supranuclear-palsy
#15
Maura Cosseddu, Alberto Benussi, Stefano Gazzina, Marta A Manes, Valentina Dell'Era, Viviana Cristillo, Rosanna Turrone, Antonella Alberici, Barbara Borroni
BACKGROUND: Progressive supranuclear palsy is a neurodegenerative disorder characterized by high functional disability and rapidly progressive dependency. The predictors of survival are still unclear. METHODS: The predictors of survival were evaluated in a group of clinically diagnosed PSP patients, focusing primarily on extensive cognitive assessment. RESULTS: The mean survival time from symptom onset was 8.25±3.0years. Sex, age at onset, education, occupation and severity of extrapyramidal symptoms did not correlate with survival...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29109054/assessing-the-presence-of-marine-toxins-in-bivalve-molluscs-from-southwest-india
#16
Andrew D Turner, Monika Dhanji-Rapkova, Stephanie Rowland-Pilgrim, Lucy M Turner, Ashwin Rai, Moleyur N Venugopal, Indrani Karunasagar, Anna Godhe
The south west coast of India has been showing a steady increase in shellfish cultivation both for local consumption and fishery export, over recent years. Perna viridis and Crassostrea madrasensis are two species of bivalve molluscs which grow in some selected regions of southern Karnataka, close to the city of Mangalore. In the early 1980s, shellfish consumers in the region were affected by intoxication from Paralytic Shellfish Poison present in local bivalves (clams and oysters) resulting in hospitalisation of many, including one fatality...
November 3, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29107645/cerebrospinal-fluid-levels-of-coenzyme-q10-are-reduced-in-multiple-system-atrophy
#17
Yaroslau Compta, Darly M Giraldo, Esteban Muñoz, Francesca Antonelli, Manel Fernández, Paloma Bravo, Marta Soto, Ana Cámara, Ferran Torres, María José Martí
INTRODUCTION: The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA...
October 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29107053/conserved-brain-myelination-networks-are-altered-in-alzheimer-s-and-other-neurodegenerative-diseases
#18
Mariet Allen, Xue Wang, Jeremy D Burgess, Jens Watzlawik, Daniel J Serie, Curtis S Younkin, Thuy Nguyen, Kimberly G Malphrus, Sarah Lincoln, Minerva M Carrasquillo, Charlotte Ho, Paramita Chakrabarty, Samantha Strickland, Melissa E Murray, Vivek Swarup, Daniel H Geschwind, Nicholas T Seyfried, Eric B Dammer, James J Lah, Allan I Levey, Todd E Golde, Cory Funk, Hongdong Li, Nathan D Price, Ronald C Petersen, Neill R Graff-Radford, Steven G Younkin, Dennis W Dickson, Julia R Crook, Yan W Asmann, Nilüfer Ertekin-Taner
INTRODUCTION: Comparative transcriptome analyses in Alzheimer's disease (AD) and other neurodegenerative proteinopathies can uncover both shared and distinct disease pathways. METHODS: We analyzed 940 brain transcriptomes including patients with AD, progressive supranuclear palsy (PSP; a primary tauopathy), and control subjects. RESULTS: We identified transcriptional coexpression networks implicated in myelination, which were lower in PSP temporal cortex (TCX) compared with AD...
October 26, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29106364/the-kidney-cancer-research-priority-setting-partnership-identifying-the-top-10-research-priorities-as-defined-by-patients-caregivers-and-expert-clinicians
#19
Jennifer Jones, Jaimin Bhatt, Jonathan Avery, Andreas Laupacis, Katherine Cowan, Naveen Basappa, Joan Basiuk, Christina Canil, Sohaib Al-Asaaed, Daniel Heng, Lori Wood, Dawn Stacey, Christian Kollmannsberger, Michael A S Jewett
It is critically important to define disease-specific research priorities to better allocate limited resources. There is growing recognition of the value of involving patients and caregivers, as well as expert clinicians in this process. To our knowledge, this has not been done this way for kidney cancer. Using the transparent and inclusive process established by the James Lind Alliance, the Kidney Cancer Research Network of Canada (KCRNC) sponsored a collaborative consensus-based priority-setting partnership (PSP) to identify research priorities in the management of kidney cancer...
November 1, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29105360/pseudoprogression-as-an-adverse-event-of-glioblastoma-therapy
#20
Carmen Balaña, Jaume Capellades, Estela Pineda, Anna Estival, Josep Puig, Sira Domenech, Eugenia Verger, Teresa Pujol, Maria Martinez-García, Laura Oleaga, JoseMaria Velarde, Carlos Mesia, Rafael Fuentes, Jordi Marruecos, Sonia Del Barco, Salvador Villà, Cristina Carrato, Oscar Gallego, Miguel Gil-Gil, Jordi Craven-Bartle, Francesc Alameda
We explored predictive factors of pseudoprogression (PsP) and its impact on prognosis in a retrospective series of uniformly treated glioblastoma patients. Patients were classified as having PsP, early progression (eP) or neither (nP). We examined potential associations with clinical, molecular, and basal imaging characteristics and compared overall survival (OS), progression-free survival (PFS), post-progression survival (PPS) as well as the relationship between PFS and PPS in the three groups. Of the 256 patients studied, 56 (21...
November 3, 2017: Cancer Medicine
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