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https://www.readbyqxmd.com/read/28719053/microwave-assisted-synthesis-of-metal-organic-framework-mil-101-nanocrystals-as-sorbent-and-pseudostationary-phase-in-capillary-electrophoresis-for-the-separation-of-anthraquinones-in-environmental-water-samples
#1
Yue Liu, Jia Hu, Yan Li, Yun-Tao Shang, Jia-Qi Wang, Ye Zhang, Zhong-Liang Wang
In this work, a CE method was developed to separate five anthraquinones: aloe-emodin, rhein, emodin, chrysophanol and physcion. The CE method used a nano-sized metal organic framework MIL-101 (nMIL-101) as pseudostationary phase (PSP) and sorbent for dispersed particle extraction (DPE). The nMIL-101 was synthesized by microwave technique and was characterized by UV-vis, TEM, Zeta potential, X-ray diffraction spectrometry and micropore physisorption. In this method, anthraquinones were adsorbed by nMIL-101 of a fast kinetics within 10 min and then separated by CE...
July 18, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28716886/clinical-neurology-and-epidemiology-of-the-major-neurodegenerative-diseases
#2
Michael G Erkkinen, Mee-Ohk Kim, Michael D Geschwind
Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in older adults. Most clinicians who care for the elderly are not trained to diagnose these conditions, perhaps other than typical Alzheimer's disease (AD). Each of these disorders has varied epidemiology, clinical symptomatology, laboratory and neuroimaging features, neuropathology, and management. Thus, it is important that clinicians be able to differentiate and diagnose these conditions accurately. This review summarizes and highlights clinical aspects of several of the most commonly encountered neurodegenerative diseases, including AD, frontotemporal dementia (FTD) and its variants, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and Huntington's disease (HD)...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28714593/free-water-improves-detection-of-changes-in-the-substantia-nigra-in-parkinsonism-a-multisite-study
#3
Edward Ofori, Florian Krismer, Roxana G Burciu, Ofer Pasternak, Johanna L McCracken, Mechelle M Lewis, Guangwei Du, Nikolaus R McFarland, Michael S Okun, Werner Poewe, Christoph Mueller, Elke R Gizewski, Michael Schocke, Christian Kremser, Hong Li, Xuemei Huang, Klaus Seppi, David E Vaillancourt
BACKGROUND: Imaging markers that are sensitive to parkinsonism across multiple sites are critically needed for clinical trials. The objective of this study was to evaluate changes in the substantia nigra using single- and bi-tensor models of diffusion magnetic resonance imaging in PD, MSA, and PSP. METHODS: The study cohort (n = 425) included 107 healthy controls and 184 PD, 63 MSA, and 71 PSP patients from 3 movement disorder centers. Bi-tensor free water, free-water-corrected fractional anisotropy, free-water-corrected mean diffusivity, single-tensor fractional anisotropy, and single-tensor mean diffusivity were computed for the anterior and posterior substantia nigra...
July 17, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28712594/an-age-stratified-longitudinal-study-of-primary-spontaneous-pneumothorax
#4
Yuan Huei Huang, Pei Yeh Chang, Kin Sun Wong, Chee Jen Chang, Jin Yao Lai, Jeng Chang Chen
PURPOSE: The objective of this study was to determine the age-stratified incidence, frequency, and duration of recurrence of primary spontaneous pneumothorax (PSP). METHODS: This study analyzed the epidemiology of PSP among hospitalized patients using the National Health Research Institutes of Taiwan database. The incidence of PSP was determined from a cohort of 19,562 deidentified individuals with PSP between 2001 and 2013. The insurants consisted of 99% of the Taiwan population of about 23 million people...
July 13, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28708906/effectiveness-of-periapical-radiography-versus-cone-beam-computed-tomography-with-different-kilovoltage-settings-in-the-detection-of-chemically-created-peri-implant-bone-defects-an-in-vitro-study
#5
Lucas Rodrigues Pinheiro, William C Scarfe, Marcelo Augusto de Oliveira Sales, Bruno Felipe Gaia, Arthur Rodriguez Gonzalez Cortes, Marcelo Gusmão Paraiso Cavalcanti
PURPOSE: To determine the effectiveness of cone beam computed tomography (CBCT) images obtained with different kilovoltage settings compared with intraoral periapical photostimulable storage phosphor (PSP) plate images in the detection of chemically created peri-implant defects utilizing a bovine rib bone model in vitro. MATERIALS AND METHODS: After placing 80 implants in bovine ribs, peri-implant circumferential bone defects of different sizes were created with 70% perchloric acid...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28708718/pulmonary-apical-opacities-on-thin-section-computed-tomography-relationship-to-primary-spontaneous-pneumothorax-in-young-male-patients-and-corresponding-histopathologic-findings
#6
Noriko Sudo Kobayashi, Atsushi Nambu, Masashi Kawamoto, Takana Yamakawa Hayashi, Masato Watanabe, Takehiro Okumura, Shozo Fujino, Tatsuya Aso, Mikiko Takahashi, Yugo Okabe, Hikari Koyama, Tadashi Kohyama, Masao Tago
OBJECTIVE: The purpose of this study was to test the hypothesis that apical opacities on computed tomography (CT) are related to occurrence of primary spontaneous pneumothorax (PSP) in young male patients. METHODS: We compared the frequency of apical opacities on thin-section CT between 70 male patients with PSP (PSP group) and 74 male patients without a history of PSP (non-PSP group). We also evaluated histopathologic findings of 39 specimens from 37 surgical cases in the PSP group...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28706282/retinal-degeneration-in-progressive-supranuclear-palsy-measured-by-optical-coherence-tomography-and-scanning-laser-polarimetry
#7
Birthe Stemplewitz, Robert Kromer, Eik Vettorazzi, Ute Hidding, Andreas Frings, Carsten Buhmann
This cross-sectional study compared the retinal morphology between patients with progressive supranuclear palsy (PSP) and healthy controls. (The retinal nerve fiber layer (RNFL) around the optic disc and the retina in the macular area of 22 PSP patients and 151 controls were investigated by spectral domain optical coherence tomography (SD-OCT). Additionally, the RNFL and the nerve fiber index (NFI) were measured by scanning laser polarimetry (SLP). Results of RNFL measurements with SD-OCT and SLP were compared to assess diagnostic discriminatory power...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705587/diagnosis-of-parkinson-s-disease-and-the-level-of-oxidized-dj-1-protein
#8
Yuko Yamagishi, Kazumasa Saigoh, Yoshiro Saito, Ikuko Ogawa, Yoshiyuki Mitsui, Yukihiro Hamada, Makoto Samukawa, Hidekazu Suzuki, Motoi Kuwahara, Makito Hirano, Noriko Noguchi, Susumu Kusunoki
Parkinson's disease (PD) is difficult to distinguish from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA); in addition, biomarker studies in PD mostly focused on those found in the cerebrospinal fluid, and there are few reports of simple biomarkers identified by blood analysis. Previously, the DJ-1 gene was identified as a causative gene of familial PD. Oxidized DJ-1 protein (oxDJ-1) levels were reported to increase in the blood of patients with unmedicated PD. Therefore, we determined the levels of oxDJ-1 in the erythrocytes of patients with PD, PSP, and MSA using ELISA...
July 10, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28704733/reversal-of-long-term-potentiation-like-plasticity-in-primary-motor-cortex-in-patients-with-progressive-supranuclear-palsy
#9
Matteo Bologna, Kelly Bertram, Giulia Paparella, Claudia Papi, Daniele Belvisi, Antonella Conte, Antonio Suppa, David R Williams, Alfredo Berardelli
OBJECTIVE: Abnormal primary motor cortex plasticity might be involved in the pathophysiology of progressive supranuclear palsy. In the present study we aimed to investigate possible abnormalities of depotentiation, a mechanism involved in plasticity regulation, in this condition. METHODS: Primary motor cortex excitability, investigated with single and paired-pulse transcranial magnetic stimulation, as well as long-term potentiation-like plasticity and its reversibility, were studied using theta burst stimulation in 15 patients with progressive supranuclear palsy and 11 healthy controls...
June 27, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28702774/do-fsh-lh-ratio-and-gonadal-hormone-levels-predict-clinical-improvement-in-postmenopausal-schizophrenia-women
#10
Alexandre González-Rodríguez, Miquel Bernardo, Rafael Penadés, Bárbara Arias, Victoria Ruiz Cortés, Mary V Seeman, Rosa Catalán
Menopause is a process characterized by a decline in estrogen levels and is therefore a period of biological vulnerability for psychotic relapse in women with schizophrenia. Our goal was to correlate not only gonadal hormone levels but also follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels with improvement in specific clinical symptoms. Thirty-seven acutely ill postmenopausal schizophrenia women with a newly initiated, clinically determined change in antipsychotic medication participated in a 12-week prospective observational outcome study...
July 12, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28702192/freezing-of-gait-is-an-early-clinical-feature-of-progressive-supranuclear-palsy
#11
Yasushi Osaki, Yukari Morita, Yuka Miyamoto, Kounosuke Furuta, Hirokazu Furuya
BACKGROUND AND AIM: Early clinical diagnosis of progressive supranuclear palsy (PSP) remains challenging. AIM: We attempted to identify any sign or symptom to diagnose PSP earlier. METHODS: A total of 401 patients, 40 with PSP and 361 with other neurodegenerative disorders, were included. We followed these patients for at least 1 year since 2009. We reviewed the signs and symptoms of patients with PSP in a standardized manner, and observed four manifestations: "vertical supranuclear gaze abnormality," "movement disorders," "pseudobulbar palsy" and "dementia of frontal type...
May 2017: Neurology and Clinical Neuroscience
https://www.readbyqxmd.com/read/28690971/materials-knowledge-systems-in-python-a-data-science-framework-for-accelerated-development-of-hierarchical-materials
#12
David B Brough, Daniel Wheeler, Surya R Kalidindi
There is a critical need for customized analytics that take into account the stochastic nature of the internal structure of materials at multiple length scales in order to extract relevant and transferable knowledge. Data driven Process-Structure-Property (PSP) linkages provide systemic, modular and hierarchical framework for community driven curation of materials knowledge, and its transference to design and manufacturing experts. The Materials Knowledge Systems in Python project (PyMKS) is the first open source materials data science framework that can be used to create high value PSP linkages for hierarchical materials that can be leveraged by experts in materials science and engineering, manufacturing, machine learning and data science communities...
March 2017: Integr Mater Manuf Innov
https://www.readbyqxmd.com/read/28683763/new-setting-of-neurally-adjusted-ventilatory-assist-for-noninvasive-ventilation-by-facial-mask-a-physiologic-study
#13
Federico Longhini, Chun Pan, Jianfeng Xie, Gianmaria Cammarota, Andrea Bruni, Eugenio Garofalo, Yi Yang, Paolo Navalesi, Haibo Qiu
BACKGROUND: Noninvasive ventilation (NIV) is generally delivered using pneumatically-triggered and cycled-off pressure support (PSP) through a mask. Neurally adjusted ventilatory assist (NAVA) is the only ventilatory mode that uses a non-pneumatic signal, i.e., diaphragm electrical activity (EAdi), to trigger and drive ventilator assistance. A specific setting to generate neurally controlled pressure support (PSN) was recently proposed for delivering NIV by helmet. We compared PSN with PSP and NAVA during NIV using a facial mask, with respect to patient comfort, gas exchange, and patient-ventilator interaction and synchrony...
July 7, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28683171/developing-a-capillary-electrophoresis-based-method-for-dynamically-monitoring-enzyme-cleavage-activity-using-quantum-dots-peptide-assembly
#14
Jianhao Wang, Jie Fan, Li Liu, Shumin Ding, Xiaoqian Liu, Jianpeng Wang, Liqian Gao, Souvik Chattopadhaya, Peng Miao, Jiang Xia, Lin Qiu, Pengju Jiang
Herein, a novel assay has been developed for monitoring PreScission protease (His-PSP) mediated enzyme cleavage of ATTO 590 labeled peptide substrate (ATTO-LEV). This novel method is based on combining the use of capillary electrophoresis and fluorescence detection (CE-FL) to dynamically monitor the enzyme cleavage activity. A multivalent peptide substrate was first constructed by immobilizing His-tagged ATTO 590 labeled peptide substrate (ATTO-LEVH6) onto the surface of CdSe/ZnS quantum dots (QDs). Once successfully immobilized, the novel multivalent peptide substrate resulted in the Förster resonance energy transfer (FRET) from QDs to ATTO 590...
July 6, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28680011/bioresorbable-vascular-scaffolds%C3%A3-are-we-facing-a-time-of-crisis-or-one-of-breakthrough
#15
Jeehoon Kang, Jung-Kyu Han, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim
Current 2nd-generation drug-eluting stents (DES) have dramatically improved clinical outcomes after percutaneous coronary intervention for coronary artery disease. However, DES implantation has major long-term limitations related to the permanent presence of foreign material in the coronary artery. Bioresorbable vascular scaffolds (BVS) were designed to overcome this limitation of permanent metal-based DES. However, because of immature manufacturing technology, BVS have several drawbacks, such as the thicker strut, poor deliverability, poor radio-opacity, poor radial strength, and cumbersome procedure to meet the principle of PSP (Preparation, Sizing, and Post-dilatation)...
July 6, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28661471/development-and-validation-of-a-liquid-chromatography-tandem-mass-spectrometry-method-coupled-with-dispersive-solid-phase-extraction-for-simultaneous-quantification-of-eight-paralytic-shellfish-poisoning-toxins-in-shellfish
#16
Xianli Yang, Lei Zhou, Yanglan Tan, Xizhi Shi, Zhiyong Zhao, Dongxia Nie, Changyan Zhou, Hong Liu
In this study, a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed for simultaneous determination of eight paralytic shellfish poisoning (PSP) toxins, including saxitoxin (STX), neosaxitoxin (NEO), gonyautoxins (GTX1-4) and the N-sulfo carbamoyl toxins C1 and C2, in sea shellfish. The samples were extracted by acetonitrile/water (80:20, v/v) with 0.1% formic and purified by dispersive solid-phase extraction (dSPE) with C18 silica and acidic alumina. Qualitative and quantitative detection for the target toxins were conducted under the multiple reaction monitoring (MRM) mode by using the positive electrospray ionization (ESI) mode after chromatographic separation on a TSK-gel Amide-80 HILIC column with water and acetonitrile...
June 29, 2017: Toxins
https://www.readbyqxmd.com/read/28660745/prolidase-is-a-critical-enzyme-for-complete-gliadin-digestion-in-tenebrio-molitor-larvae
#17
Valeriia F Tereshchenkova, Irina A Goptar, Dmitry P Zhuzhikov, Mikhail A Belozersky, Yakov E Dunaevsky, Brenda Oppert, Irina Yu Filippova, Elena N Elpidina
Prolidase is a proline-specific metallopeptidase that cleaves imidodipeptides with C-terminal Pro residue. Prolidase was purified and characterized from the Tenebrio molitor larval midgut. The enzyme was localized in the soluble fraction of posterior midgut tissues, corresponding to a predicted cytoplasmic localization of prolidase according to the structure of the mRNA transcript. Expression of genes encoding prolidase and the major digestive proline-specific peptidase (PSP)-dipeptidyl peptidase 4-were similar...
June 29, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/28655179/to-err-is-perfectly-human-behavioural-and-neural-correlates-of-error-processing-and-perfectionism
#18
Antonia Barke, Stefan Bode, Peter Dechent, Carsten Schmidt-Samoa, Christina Van Heer, Jutta Stahl
The attitude towards one's own imperfection strongly varies between individuals. Here, we investigated variations in error-related activity depending on two sub-traits of perfectionism, Personal Standard Perfectionism (PSP) and Evaluative Concern Perfectionism (ECP) in a large scale functional magnetic resonance imaging study (N = 75) using a digit-flanker task. Participants with higher PSP scores showed both more post-error slowing and more neural activity in the medial-frontal gyrus including anterior cingulate cortex after errors...
June 26, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28653647/advances-in-progressive-supranuclear-palsy-new-diagnostic-criteria-biomarkers-and-therapeutic-approaches
#19
REVIEW
Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinger
Progressive supranuclear palsy (PSP), previously believed to be a common cause of atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes that are associated with a characteristic 4-repeat tau neuropathology. New research criteria that recognise early presentations of PSP and operationalise diagnosis of the full spectrum of clinical phenotypes have been reported. The Movement Disorders Society PSP diagnostic criteria include syndromes with few or mild symptoms that are suggestive of underlying PSP pathology and could provide an opportunity for earlier therapeutic interventions in the future...
July 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28635192/incidence-of-primary-spontaneous-pneumothorax-is-not-associated-with-microclimatic-variations-results-of-a-seven-year-survey-in-a-temperate-climate-area
#20
Ivan Comelli, Alessandra Bologna, Andrea Ticinesi, Andrea Magnacavallo, Denis Comelli, Tiziana Meschi, Gianfranco Cervellin
Some diseases, such as renal colic and atrial fibrillation, display an association with microclimatic variations. In particular, despite a correlation has been reported between incidence of primary spontaneous pneumothorax (PSP) and meteorological variations, the evidence remains poor and conflictual. The aim of this study was to assess the influence of day-by-day meteorological variations on the number of visits for PSP in the Emergency Department (ED). All PSP cases were retrieved from the hospital database from January 2008 to December 2014...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
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