Yi Chen, Yunyun Wang, Qingqing Tao, Peilin Lu, Fanxia Meng, Liying Zhuang, Song Qiao, Ying Zhang, Benyan Luo, Yang Liu, Guoping Peng
BACKGROUND: Plasma amyloid-β (Aβ), phosphorylated tau-181 (p-tau181), neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) potentially aid in the diagnosis of neurodegenerative dementias. We aim to conduct a comprehensive comparison between different biomarkers and their combination, which is lacking, in a multicenter Chinese dementia cohort consisting of Alzheimer's disease (AD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP). METHODS: We enrolled 92 demented patients [64 AD, 16 FTD, and 12 PSP with dementia] and 20 healthy controls (HC)...
April 6, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry