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https://www.readbyqxmd.com/read/29333474/saccades-in-progressive-supranuclear-palsy-maladapted-irregular-curved-and-slow
#1
Aasef G Shaikh, Stewart A Factor, Jorge Juncos
Background and objectives: Slowed and curved rapid eye movements, saccades, are the well-known features of progressive supranuclear palsy (PSP). We hypothesized that the saccades in PSP are not only slow and curved, but they are also irregular and have timing deficits. Methods: We tested this hypothesis in 12 patients with PSP by measuring vertical and horizontal visually guided saccades using a limbus tracker. Results: Both, horizontal and vertical saccades were slow and had irregular trajectory and velocity profiles, but deficits were much more robust in vertical saccades...
September 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/29319907/aberrant-accumulation-of-erbb4-in-progressive-supranuclear-palsy
#2
Aya Murakami, Masataka Nakamura, Satoshi Kaneko, Wen-Lang Lin, Dennis W Dickson, Hirofumi Kusaka
The human epidermal growth factor receptor family consists of 4 members that belong to the ErbB lineage of proteins (ErbB1-4). Neuregulin-1 (NRG1)/ErbB signalling regulates brain development and function. Abnormalities in this signalling have been implicated in the aetiology or development of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. So, we aimed at investigating whether the expression of NRG1 or ErbB proteins are altered in progressive supranuclear palsy (PSP) METHODS: The brains of 10 PSP and 6 control patients were investigated by immunohistochemical analysis RESULTS: Whereas C-terminal ErbB4 immunoreacitivity was partially but distinctly present in the cytoplasm and/or in the nucleus of neurons in control patients, it was rarely observed in the neuronal nuclei in PSP patients...
January 10, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29315334/immune-related-genetic-enrichment-in-frontotemporal-dementia-an-analysis-of-genome-wide-association-studies
#3
Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue
BACKGROUND: Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD risk, a systematic investigation of genetic overlap between immune-mediated diseases and the spectrum of FTD-related disorders has not been performed. METHODS AND FINDINGS: Using large genome-wide association studies (GWASs) (total n = 192,886 cases and controls) and recently developed tools to quantify genetic overlap/pleiotropy, we systematically identified single nucleotide polymorphisms (SNPs) jointly associated with FTD-related disorders-namely, FTD, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)-and 1 or more immune-mediated diseases including Crohn disease, ulcerative colitis (UC), rheumatoid arthritis (RA), type 1 diabetes (T1D), celiac disease (CeD), and psoriasis...
January 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29314591/relationship-between-metacognitive-beliefs-and-psychosocial-performance-in-at-risk-states-of-psychosis-and-patients-with-first-psychotic-episodes
#4
Martin Brüne, Kim-Alisha Drommelschmidt, Seza Krüger-Özgürdal, Georg Juckel
AIMS: Improving diagnostic batteries to identify individuals at-risk for developing psychotic disorders as early as possible is an ongoing challenge in schizophrenia research. Here, we sought to explore whether metacognition in at-risk of developing psychosis would differ from that of first episode psychosis and unaffected controls and whether dysfunctional metacognitive beliefs would be associated with psychosocial functioning in the clinical groups. METHODS: Twenty-three subjects at-risk of psychosis were compared with a group of 15 first psychotic episode patients and 21 healthy controls with regard to their metacognitive beliefs and psychosocial functioning...
January 4, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29312731/does-oxygen-therapy-increase-the-resolution-rate-of-primary-spontaneous-pneumothorax
#5
Chan Beom Park, Mi Hyoung Moon, Hyun Woo Jeon, Deog Gon Cho, Sun Wha Song, Yoo Dong Won, Yong Hwan Kim, Young-Du Kim, Seong Cheol Jeong, Kyung Soo Kim, Si Young Choi
Background: Patients with small pneumothoraces are usually treated with oxygen therapy. However, evidence that oxygen therapy increases resolution rate is based on small populations with secondary spontaneous pneumothorax. Therefore, this study aimed to confirm whether oxygen therapy increases the resolution rate of primary spontaneous pneumothorax (PSP). Methods: We retrospectively reviewed records of patients with PSP who had undergone outpatient observation (room air group) and those who were admitted for oxygen therapy (O2 group) between March 2005 and February 2016...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29307007/neurophysiology-and-neurochemistry-of-corticobasal-syndrome
#6
REVIEW
Aditya A Murgai, Mandar S Jog
Corticobasal syndrome is a rare neurodegenerative disorder, which presents with a progressive, asymmetrical, akinetic rigid syndrome and early cortical signs. However, clinical, pathological, and electrophysiological heterogeneity makes the understanding of this syndrome challenging. Corticobasal syndrome can have various pathological substrates including corticobasal degeneration, Alzheimer's disease, Fronto-temporal degeneration with TDP inclusions, Creutzfeldt-Jakob disease, and progressive supranuclear palsy (PSP)...
January 6, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29304218/selective-vulnerability-of-brainstem-nuclei-in-distinct-tauopathies-a-postmortem-study
#7
Rana A Eser, Alexander J Ehrenberg, Cathrine Petersen, Sara Dunlop, Maria B Mejia, Claudia K Suemoto, Christine M Walsh, Hima Rajana, Jun Oh, Panos Theofilas, William W Seeley, Bruce L Miller, Thomas C Neylan, Helmut Heinsen, Lea T Grinberg
The brainstem nuclei of the reticular formation (RF) are critical for regulating homeostasis, behavior, and cognition. RF degenerates in tauopathies including Alzheimer disease (AD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Although the burden of phopho-tau inclusion is high across these diseases, suggesting a similar vulnerability pattern, a distinct RF-associated clinical phenotype in these diseases indicates the opposite. To compare patterns of RF selective vulnerability to tauopathies, we analyzed 5 RF nuclei in tissue from 14 AD, 14 CBD, 10 PSP, and 3 control cases...
January 2, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29304167/the-language-disorder-of-prion-disease-is-characteristic-of-a-dynamic-aphasia-and-is-rarely-an-isolated-clinical-feature
#8
Diana Caine, Akin Nihat, Philippa Crabb, Peter Rudge, Lisa Cipolotti, John Collinge, Simon Mead
BACKGROUND: Akinetic mutism is a key diagnostic feature of prion diseases, however, their rapidly progressive nature makes detailed investigation of the language disorder in a large cohort extremely challenging. This study aims to position prion diseases in the nosology of language disorders and improve early clinical recognition. METHODS: A systematic, prospective investigation of language disorders in a large cohort of patients diagnosed with prion diseases. 568 patients were included as a sub-study of the National Prion Monitoring Cohort...
2018: PloS One
https://www.readbyqxmd.com/read/29298916/computed-radiography-photostimulable-phosphor-plate-receptors-effect-on-grid-conversion-factors
#9
Lauren B Noble, Melissa P Culp
BACKGROUND: Grid conversion factors were established for using grids with varying ratios for film-screen systems. Evidence from the physics community suggests that the relationship between grid conversion factors and exposure to the receptor does not apply with different types of digital imaging receptors. PURPOSE: To evaluate the relationship among analog grid conversion factors when using various grid ratios with a photostimulable phosphor plate (PSP) receptor system...
November 2017: Radiologic Technology
https://www.readbyqxmd.com/read/29295481/uniformity-study-of-two-functional-luminescent-dyes-adsorbed-over-an-anodized-aluminum-coating-for-motion-capturing-pressure-and-temperature-sensitive-paint-imaging
#10
Masato Ishii, Takeshi Miyazaki, Hirotaka Sakaue
The pressure- and temperature-sensitive paint (PSP/TSP) technique, for steady-state and unsteady-state measurements, is becoming widespread. However, unsteady quantitative measurement is still difficult because non-uniform distribution of the probes over a test model may cause errors in the results. We focus on the dipping method that applies two luminophores into a binding material to improve sensitivity uniformity over a model surface. A bullet-shaped axisymmetric test model with motion-capturing TSP was used to evaluate the sensitivity uniformity, and three dipping methods (static, convectional, and rotational) were examined...
December 23, 2017: Sensors
https://www.readbyqxmd.com/read/29290080/burden-between-undersupply-and-overtreatment-in-the-care-of-primary-spontaneous-pneumothorax
#11
Hans-Stefan Hofmann, Tobias Suttner, Reiner Neu, Tobias Potzger, Tamas Szöke, Christian Grosser, Michael Ried
BACKGROUND:  The optimal treatment of primary spontaneous pneumothorax (PSP) is still controversial. The purpose of this study was to analyze the incidence of recurrence, the recurrence-free time, and to identify risk factors for recurrence after PSP. METHODS:  We performed a retrospective analysis of 135 patients with PSP who were treated either conservatively with a chest tube (n = 87) or surgically with video-assisted thoracoscopic surgery (VATS; n = 48) from January 2008 through December 2012...
December 31, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29289322/effects-of-structure-on-the-performance-of-latex-nanoparticles-as-a-pseudostationary-phase-in-electrokinetic-chromatography
#12
Jesse S Hyslop, Julie R McGettrick, Leah M G Hall, Hungngai Chuk, Christopher P Palmer
The fundamental relationships between the structure and chemistry of latex nanoparticles synthesized by reversible addition fragmentation chain transfer (RAFT) controlled living polymerization and their subsequent performance as pseudostationary phases (PSP) are reported in this paper. RAFT enables the rational optimization of latex nanoparticle pseudostationary phases and control of the behavior of the PSP. Nanoparticles comprised of amphiphilic diblock copolymers of 2-acrylamido-2-methylpropane sulfonic acid-derived ionic/hydrophilic blocks and butyl- ethyl- or methyl-acrylate-derived hydrophobic blocks were synthesized in two sizes...
February 13, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29282336/csf-neurofilament-light-chain-and-phosphorylated-tau-181-predict-disease-progression-in-psp
#13
Julio C Rojas, Jee Bang, Iryna V Lobach, Richard M Tsai, Gil D Rabinovici, Bruce L Miller, Adam L Boxer
OBJECTIVE: To determine the ability of CSF biomarkers to predict disease progression in progressive supranuclear palsy (PSP). METHODS: We compared the ability of baseline CSF β-amyloid1-42, tau, phosphorylated tau 181 (p-tau), and neurofilament light chain (NfL) concentrations, measured by INNO-BIA AlzBio3 or ELISA, to predict 52-week changes in clinical (PSP Rating Scale [PSPRS] and Schwab and England Activities of Daily Living [SEADL]), neuropsychological, and regional brain volumes on MRI using linear mixed effects models controlled for age, sex, and baseline disease severity, and Fisher F density curves to compare effect sizes in 50 patients with PSP...
December 27, 2017: Neurology
https://www.readbyqxmd.com/read/29281045/protein-phosphatase-2a-and-its-methylation-modulating-enzymes-lcmt-1-and-pme-1-are-dysregulated-in-tauopathies-of-progressive-supranuclear-palsy-and-alzheimer-disease
#14
Hye-Jin Park, Kang-Woo Lee, Stephanie Oh, Run Yan, Jie Zhang, Thomas G Beach, Charles H Adler, Michael Voronkov, Steven P Braithwaite, Jeffry B Stock, M Maral Mouradian
Hyperphosphorylated tau aggregates are characteristic of tauopathies including progressive supranuclear palsy (PSP) and Alzheimer disease (AD), but factors contributing to pathologic tau phosphorylation are not well understood. Here, we studied the regulation of the major tau phosphatase, the heterotrimeric AB55αC protein phosphatase 2 A (PP2A), in PSP and AD. The assembly and activity of this PP2A isoform are regulated by reversible carboxyl methylation of its catalytic C subunit, while the B subunit confers substrate specificity...
December 21, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29279191/mr-findings-in-the-substantia-nigra-on-phase-difference-enhanced-imaging-in-neurodegenerative-parkinsonism
#15
Atsuhiko Sugiyama, Noriko Sato, Yukio Kimura, Miho Ota, Tomoko Maekawa, Daichi Sone, Mikako Enokizono, Miho Murata, Hiroshi Matsuda, Satoshi Kuwabara
INTRODUCTION: In Parkinson's disease (PD) patients, magnetic resonance (MR) imaging studies using phase difference enhanced imaging (PADRE) and susceptibility-weighted imaging (SWI) showed the obscuration of the boundary between the crural fibers and substantia nigra, and the absence of dorsolateral nigral hyperintensity, respectively. PADRE images have not been evaluated in other types of neurodegenerative parkinsonism, and PADRE and SWI images have not been compared. Here we evaluated PADRE and SWI images in patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), or PD and controls, and we compared the diagnostic values...
December 21, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29278274/the-tau-positron-emission-tomography-tracer-av-1451-binds-with-similar-affinities-to-tau-fibrils-and-monoamine-oxidases
#16
Céline Vermeiren, Philippe Motte, Delphine Viot, Georges Mairet-Coello, Jean-Philippe Courade, Martin Citron, Joël Mercier, Jonas Hannestad, Michel Gillard
BACKGROUND: Lilly/Avid's AV-1451 is one of the most advanced tau PET tracers in the clinic. Although results obtained in Alzheimer's disease patients are compelling, discrimination of tracer uptake in healthy individuals and patients with supranuclear palsy (PSP) is less clear as there is substantial overlap of signal in multiple brain regions. Moreover, accurate quantification of [18 F]AV-1451 uptake in Alzheimer's disease may not be possible. OBJECTIVES: The aim of the present study was to characterize the in vitro binding of AV-1451 to understand and identify potential off-target binding that could explain the poor discrimination observed in PSP patients...
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29277465/optimal-timing-of-video-assisted-thoracoscopic-surgery-for-primary-spontaneous-pneumothorax-in-children
#17
Kibileri Williams, Timothy B Lautz, Astrid H Leon, Tolulope A Oyetunji
PURPOSE: There is no consensus in the pediatric surgical community about when to recommend video-assisted thoracoscopic surgery (VATS) for patients with primary spontaneous pneumothorax (PSP). We aimed to identify factors that predict the likelihood of requiring VATS, and to compare recurrence rates and healthcare utilization among different management approaches to PSP. METHODS: A retrospective chart review and a telephone survey were conducted on all patients 12-21years who were diagnosed with PSP from 2007 to 2015...
November 23, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29262448/-application-of-functional-parotidectomy-via-retroauricular-hairline-incision-in-the-excising-superficial-parotid-tumor
#18
P A Wu, Z Q Lu, Y F Guan, H L Zhu, X N Liang, W Y Liang, R K Tsang
Objective: To evaluate the usefulness of retroauricular hairline incision (RAHI) in partial superficial parotidectomy (PSP) by comparison with modified Blair incision (MBI). Methods: A retrospective analysis of 64 medical records for patients with benign parotid tumors who underwent partial superficial parotidectomy was undertaken (28 were in MBI group, 36 in RAHI group). Size and location of tumors, operative time, occurrence of facial nerve paralysis and Frey's syndrome, and cosmetic outcomes were compared between RAHI and MBI groups...
December 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29246390/the-extent-of-surgery-for-benign-parotid-pathology-and-its-influence-on-complications-a-prospective-cohort-analysis
#19
Wai Keat Wong, Subhaschandra Shetty
BACKGROUND: The surgical management of benign parotid tumors is aimed at complete extirpation of the mass with preservation of facial nerve function. There is a relative paucity of literature pertaining to complications after benign parotid surgery and related risk factors. We aim to critically review the outcomes following treatment of benign parotid pathology when surgery entailed either complete superficial parotidectomy (CSP), partial superficial parotidectomy (PSP) or extracapsular dissection (ECD)...
November 29, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29245876/automated-approach-for-the-surface-profile-measurement-of-moving-objects-based-on-psp
#20
Lei Lu, Yi Ding, Yinsen Luan, Yongkai Yin, Qiong Liu, Jiangtao Xi
Phase shifting profilometry can achieve high accuracy for the 3D shape measurement of static object. Errors will be introduced when the object is moved during the movement. The fundamental reason causing the above issue is: PSP requires multiple fringe patterns but the reconstruction model does not include the object movement information. This paper proposes a new method to automatically measure the 3D shape of the rigid object with arbitrary 2D movement. Firstly, the object movement is tracked by the SIFT algorithm and the rotation matrix and translation vector describing the movement are estimated...
December 11, 2017: Optics Express
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