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neurologic disturbances in pregnancy

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https://www.readbyqxmd.com/read/26989522/wernicke-s-encephalopathy-complicating-hyperemesis-during-pregnancy
#1
Mohamed Adnane Berdai, Smael Labib, Mustapha Harandou
Wernicke's encephalopathy is caused by severe thiamine deficiency; it is mostly observed in alcoholic patients. We report the case of a 28-year-old woman, at 17 weeks of gestational age, with severe hyperemesis gravidarum. She presented with disturbance of consciousness, nystagmus, ophthalmoplegia, and ataxia. The resonance magnetic imagery showed bilaterally symmetrical hyperintensities of thalamus and periaqueductal area. The case was managed with very large doses of thiamine. The diagnosis of Wernicke's encephalopathy was confirmed later by a low thiamine serum level...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/26953551/-neurological-disorders-and-pregnancy
#2
P Berlit
Neurological disorders caused by pregnancy and puerperium include the posterior reversible encephalopathy syndrome, the amniotic fluid embolism syndrome (AFES), the postpartum angiopathy due to reversible vasoconstriction syndrome, and the Sheehan syndrome. Hypertension and proteinuria are the hallmarks of preeclampsia, seizures define eclampsia. Hemolysis, elevated liver enzymes and low platelets constitute the HELLP syndrome. Vision disturbances including cortical blindness occur in the posterior reversible encephalopathy syndrome (PRES)...
February 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/26924398/the-metabolic-basis-for-developmental-disorders-due-to-defective-folate-transport
#3
REVIEW
Ankuri Desai, Jeffrey M Sequeira, Edward V Quadros
Folates are essential in the intermediary metabolism of amino acids, synthesis of nucleotides and for maintaining methylation reactions. They are also linked to the production of neurotransmitters through GTP needed for the synthesis of tetrahydrobiopterin. During pregnancy, folate is needed for fetal development. Folate deficiency during this period has been linked to increased risk of neural tube defects. Disturbances of folate metabolism due to genetic abnormalities or the presence of autoantibodies to folate receptor alpha (FRα) can impair physiologic processes dependent on folate, resulting in a variety of developmental disorders including cerebral folate deficiency syndrome and autism spectrum disorders...
July 2016: Biochimie
https://www.readbyqxmd.com/read/26759989/early-functional-and-morphological-brain-disturbances-in-late-onset-intrauterine-growth-restriction
#4
Mirta Starčević, Maja Predojević, Dražan Butorac, Jasna Tumbri, Paško Konjevoda, Aida Salihagić Kadić
AIMS: To determine whether the brain disturbances develop in late-onset intrauterine growth restriction (IUGR) before blood flow redistribution towards the fetal brain (detected by Doppler measurements in the middle cerebral artery and umbilical artery). Further, to evaluate predictive values of Doppler arterial indices and umbilical cord blood gases and pH for early functional and/or morphological brain disturbances in late-onset IUGR. STUDY DESIGN: This cohort study included 60 singleton term pregnancies with placental insufficiency caused late-onset IUGR (IUGR occurring after 34 gestational weeks)...
February 2016: Early Human Development
https://www.readbyqxmd.com/read/26622776/figo-stage-iv-gestational-choriocarcinoma-misdiagnosed-as-pulmonary-tuberculosis-a-case-report
#5
Lingyun Yang, Pang Xu, Mingrong Xi, Hongjing Wang
Choriocarcinoma is a rare, highly malignant neoplasm, which may occur during or following any type of pregnancy. This tumor often demonstrates rapid hematogenous spread to multiple organs, and is associated with high human chorionic gonadotropin (HCG) levels and a good response to chemotherapy. In the present study, the case of a 29-year-old female with distant metastatic choriocarcinoma [International Federation of Gynecology and Obstetrics (FIGO) stage IV; World Health Organization score, 15], who was misdiagnosed with pulmonary tuberculosis at a local hospital is presented...
September 2015: Oncology Letters
https://www.readbyqxmd.com/read/26620005/study-on-neurological-manifestations-of-eclampsia-findings-of-ct-scan-of-brain
#6
F Begum, K Nahar, M U Ahmed, R A Ferdousi, F A Akter, M M Rahman
This cross sectional study was carried out in the Department of Obstetrics & Gynaecology in Mymensingh Medical College Hospital during the period of January 2011 to December 2012 to evaluate neurological manifestations in eclampsia by CT scan of brain. A total 35 patients with eclampsia were studied, who underwent CT scan of brain in Radiology & Imaging Department of Mymensingh Medical College Hospital. The study patients were divided into two groups, those who had changes in brain on CT scan (Group A) & those who had no changes in brain on CT scan (Group B)...
October 2015: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/26162042/hormone-dependent-shrinkage-of-a-sphenoid-wing-meningioma-after-pregnancy-case-report
#7
Johannes Kerschbaumer, Christian F Freyschlag, Günter Stockhammer, Susanne Taucher, Hans Maier, Claudius Thomé, Marcel Seiz-Rosenhagen
Meningiomas are known to be associated with female sex hormones. Worsening neurological symptoms or newly diagnosed meningiomas have been described in the context of elevated levels of sex hormones, for example, in pregnancy. To the authors' knowledge, tumor shrinkage after the normalization of hormones has not been described, even if it is known that neurological deficits due to meningioma compression may improve after giving birth. A 32-year-old female patient presented with severe headache and vision disturbances at the end of her second pregnancy...
January 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26023585/posterior-reversible-encephelopathy-syndrome-presenting-as-quadriparesis-in-pregnancy-induced-hypertension
#8
Pranita, Ajit Kumar, Seema Shahi, Debasish Choudhary
Pregnancy Induced Hypertension (PIH) is a condition characterised by raised blood pressure in pregnancy. It affects approximately one out of every 14 pregnant women. Although PIH more commonly occurs during first pregnancy, it can also occur in subsequent pregnancies. It can present with variable complications related to vasospasm. But focal neurologic deficits are extremely rare in patients with PIH. We report a case of quadriparesis due to posterior reversible encephalopathy syndrome (PRES). A 36 year old full term pregnant female was admitted for emergency lower segment caesarean section (LSCS) as a result of uncontrolled PIH with early clinical signs of left ventricular failure...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25819820/primary-hyperparathyroidism-in-pregnancy-leading-to-hypercalcaemic-crisis-and-uraemic-encephalopathy
#9
E Nash, P Ranka, G Tarigopula, T Rashid
Primary hyperparathyroidism is rare during pregnancy. Recognition may be challenging as symptoms overlap with those of other common disorders of pregnancy. Furthermore, physiological changes of pregnancy affecting calcium homoeostasis mean awareness of the condition and careful interpretation of results in the light of pregnancy are essential for diagnosis. Maternal complications of primary hyperparathyroidism include nephrolithiasis, pancreatitis, cardiac arrhythmias, hypertension and peptic ulcers. At its most severe, hypercalcaemic crisis may occur, presenting with acute neurological disturbance...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/25622379/preeclampsia-an-update
#10
REVIEW
G Lambert, J F Brichant, G Hartstein, V Bonhomme, P Y Dewandre
Preeclampsia was formerly defined as a multisystemic disorder characterized by new onset of hypertension (i.e. systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg) and proteinuria (> 300 mg/24 h) arising after 20 weeks of gestation in a previously normotensive woman. Recently, the American College of Obstetricians and Gynecologists has stated that proteinuria is no longer required for the diagnosis of preeclampsia. This complication of pregnancy remains a leading cause of maternal morbidity and mortality...
2014: Acta Anaesthesiologica Belgica
https://www.readbyqxmd.com/read/25599983/outcome-of-12-antenatally-diagnosed-fetal-arachnoid-cysts-case-series-and-review-of-the-literature
#11
REVIEW
B De Keersmaecker, P Ramaekers, F Claus, I Witters, E Ortibus, G Naulaers, F Van Calenbergh, L De Catte
OBJECTIVES: To investigate the natural history, associated abnormalities and outcome of 12 fetuses with arachnoid cyst diagnosed antenatally by ultrasound and magnetic resonance imaging and to compare the outcome with cases in the literature. METHODS: A retrospective study of all cases of antenatally detected fetal arachnoid cysts was performed in patients referred to a tertiary unit between 2007 and 2013. Associated abnormalities, pregnancy outcome and postnatal follow-up were analyzed...
March 2015: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/25557619/a-requirement-for-gch1-and-tetrahydrobiopterin-in-embryonic-development
#12
Gillian Douglas, Ashley B Hale, Mark J Crabtree, Brent J Ryan, Alex Hansler, Katrin Watschinger, Steven S Gross, Craig A Lygate, Nicholas J Alp, Keith M Channon
INTRODUCTION: GTP cyclohydrolase I (GTPCH) catalyses the first and rate-limiting reaction in the synthesis of the enzymatic cofactor, tetrahydrobiopterin (BH4). Loss of function mutations in the GCH1 gene lead to congenital neurological diseases such as DOPA-responsive dystonia and hyperphenylalaninemia. However, little is known about how GTPCH and BH4 affects embryonic development in utero, and in particular whether metabolic replacement or supplementation in pregnancy is sufficient to rescue genetic GTPCH deficiency in the developing embryo...
March 1, 2015: Developmental Biology
https://www.readbyqxmd.com/read/25557100/-a-case-of-cerebellar-hemangioblastoma-complicated-by-pregnancy-and-concerns-about-the-surgical-period
#13
Akihiro Inoue, Shohei Kohno, Yoshiaki Kumon, Hideaki Watanabe, Takanori Ohnishi, Hisashi Hashimoto, Keiichi Matsubara
We report herein a case of cerebellar hemangioblastoma complicated by pregnancy and concerns about the period in which surgery could be performed successfully. A 19-year-old woman, who was also 35 weeks pregnant, was admitted to our hospital with headache, nausea, and general fatigue. Neurological examination on admission revealed disturbed consciousness, and the patient's general condition was poor. Computed tomography and magnetic resonance imaging showed a large tumor in the cerebellar vermis along with an obstructive hydrocephalus...
January 2015: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/25551975/posterior-reversible-encephalopathy-syndrome-in-obstetric-patients-report-of-three-cases-with-literature-review
#14
REVIEW
S O Altinkaya, S Nergiz, M Küçük, H Yüksel, Y Dayanir
Posterior reversible encephalopathy syndrome (PRES) is a serious clinico-neuroradiological maternal complication in pregnancy. Although it has various etiologies such as hypertensive encephalopathy, renal failure, autoimmune disorders, sepsis, multiple organ failure, and treatment with immunosuppressant or cytotoxic agents, pregnancy and postpartum complicated by hypertensive disorders more frequently lead to this condition. PRES is clinically characterized by headache, confusion, seizures, vomiting, and visual disturbances with radiographic vasogenic edema especially affecting symmetrical parietal and occipital lobes...
2014: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/25495971/management-of-neonatal-abstinence-syndrome-in-the-newborn-nursery
#15
Valarie Artigas
Maternal drug use and neonatal abstinence syndrome (NAS) are being seen across the United States. NAS occurs with withdrawal disturbances in response to the cessation of the pregnancy exposure. The clinical presentation of a newborn with NAS can include gastrointestinal, neurologic, vasomotor and respiratory symptoms. Assessment of newborns with NAS can often present as a challenge to maternal-child nurses. Treatment can include supportive care as well as pharmacologic therapies.
December 2014: Nursing for Women's Health
https://www.readbyqxmd.com/read/25488886/a-successful-spontaneous-pregnancy-in-abetalipoproteinemia-amsterdam-or-the-art-of-vitamin-replacement
#16
REVIEW
Francisca Ferreira, Vinod Patel, Suzy Matts
Abetalipoproteinemia is a rare metabolic disorder that causes disturbed lipid absorption with consequent hypocholesterolaemia and liposoluble avitaminosis. The broad spectrum of presentations includes malabsorption, failure to thrive and acanthocytosis in children, while later in life expected manifestations include coagulopathy, myopathy, retinitis pigmentosa, peripheral neuropathy, hyporeflexia and ataxia. These neurological complications stem from demyelination secondary to vitamin E deficiency. Another complication is reduced fertility in women...
2014: BMJ Case Reports
https://www.readbyqxmd.com/read/25431709/postoperative-atypical-hemolytic-uremic-syndrome-associated-with-complement-c3-mutation
#17
Eiji Matsukuma, Atsushi Imamura, Yusuke Iwata, Takamasa Takeuchi, Yoko Yoshida, Yoshihiro Fujimura, Xinping Fan, Toshiyuki Miyata, Takashi Kuwahara
Atypical hemolytic uremic syndrome (aHUS) can be distinguished from typical or Shiga-like toxin-induced HUS. The clinical outcome is unfavorable; up to 50% of affected patients progress to end-stage renal failure and 25% die during the acute phase. Multiple conditions have been associated with aHUS, including infections, drugs, autoimmune conditions, transplantation, pregnancy, and metabolic conditions. aHUS in the nontransplant postsurgical period, however, is rare. An 8-month-old boy underwent surgical repair of tetralogy of Fallot...
2014: Case Reports in Nephrology
https://www.readbyqxmd.com/read/25298089/-subjective-symptoms-and-miscarriage-after-drinking-well-water-exposed-to-diphenylarsinic-acid
#18
Tsuyoshi Ogata, Yosikazu Nakamura, Ginji Endo, Tomoshige Hayashi, Yasushi Honda
OBJECTIVES: An outbreak of neurological health disorder caused by drinking well water occurred in 2003 at one apartment building in Kamisu, Ibaraki, Japan. This was the first case of mass poisoning due to well water contaminated with diphenylarsinic acid (DPAA). Subsequently, other residents in Kamisu were confirmed to have drunk well water containing lower concentrations of DPAA. The present study aimed to investigate neurological and other subjective symptoms and miscarriage occurrences after DPAA exposure...
2014: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/25031837/a-case-of-pituitary-apoplexy-in-pregnancy
#19
Aimee R Hayes, Anthony J O'Sullivan, Mark A Davies
UNLABELLED: Pituitary apoplexy is a rare event in pregnancy. A 41-year-old woman with a known pituitary microadenoma presented with visual disturbance and headache during the second trimester of pregnancy. Magnetic resonance imaging (MRI) demonstrated pituitary apoplexy with chiasmal compression. After treatment with corticosteroid therapy, she underwent transsphenoidal excision of the pituitary adenoma. Visual abnormalities were completely restored and pituitary function preserved. There was no evidence of impact on the foetus...
2014: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/24930416/safety-of-fluoxetine-treatment-in-a-case-of-acute-intermittent-porphyria
#20
Si˙bel Mercan, Oğuz Karamustafalioglu, Ni˙lgün Tanriverdi˙, Si˙bel Oba
Acute intermittent porphyria (AIP) is a metabolic disease characterized by recurrent attacks of neurological and psychiatric dysfunction. It is a rare disorder of heme metabolism that usually presents with abdominal pain, gastrointestinal symptoms and autonomic nervous system disturbances. Exposure to certain drugs, dieting, starvation and infection during pregnancy may precipitate AIP attacks. Psychiatric manifestations of AIP include mood changes, organic brain syndrome and psychosis. Here, we present a 21-year-old female patient with AIP and major depression...
2003: International Journal of Psychiatry in Clinical Practice
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