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Tests antisocial personality disorder

Marijn Lijffijt, Scott D Lane, Sanjay J Mathew, Matthew S Stanford, Alan C Swann
We tested whether enhanced stimulus orienting operationalized as N1 and P2 auditory evoked potentials to increasing loudness (50-90 dB clicks) could be associated with trait impulsivity (Barratt Impulsiveness Scale, BIS-11), impulsive action (commission error on the Immediate Memory Task), or impulsive choice (immediate responses on temporal discounting tasks). We measured N1 and P2 loudness sensitivity in a passive listening task as linear intensity-sensitivity slopes in 36 men with antisocial personality disorder with a history of conviction for criminal conduct and 16 healthy control men...
September 23, 2016: European Archives of Psychiatry and Clinical Neuroscience
Teerayuth Rungnirundorn, Viroj Verachai, Joel Gelernter, Robert T Malison, Rasmon Kalayasiri
BACKGROUND AND OBJECTIVE: Males and females who use methamphetamine (MA) differ in sociodemographics, MA diagnoses, comorbidities, and brain activity. The objective of this study was to investigate sex differences in the characteristics of MA use and dependence in patients at a Thai substance treatment center. METHODS: Demographic, MA use, and diagnostic data for 782 MA users were obtained by using the Semi-Structured Assessment for Drug Dependence and Alcoholism-Thai version...
September 19, 2016: Journal of Addiction Medicine
Hongying Fan, Qisha Zhu, Guorong Ma, Chanchan Shen, Bingren Zhang, Wei Wang
BACKGROUND: Cultural and personality factors might contribute to the clinical differences of psychiatric patients all over the world including China. One cultural oriented Chinese Adjective Descriptors of Personality (CADP) designed to measure normal personality traits, might be specifically associated with different personality disorder functioning styles. METHODS: We therefore have invited 201 healthy volunteers and 67 personality disorder patients to undergo CADP, the Parker Personality Measure (PERM), and the Plutchik-van Praag Depression Inventory (PVP) tests...
2016: BMC Psychiatry
So Hyeon Park, Hyun Soo Park, Sang Eun Kim
Novelty seeking (NS) and antisocial personality (ASP) are commonly exhibited by those who suffer from addictions, such as substance abuse. NS has been suggested to be a fundamental aspect of ASP. To investigate the neurobiological substrate of NS and ASP, we tested the relationship between regional cerebral glucose metabolism and the level of NS, determining the differences between individuals with and without ASP. Seventy-two healthy adults (43 males, mean age±SD=38.8±16.6 years, range=20~70 years; 29 females, 44...
August 2016: Experimental Neurobiology
Roope Tikkanen, Tero Saukkonen, Malin Fex, Hedvig Bennet, Marja-Riitta Rautiainen, Tiina Paunio, Mika Koskinen, Rony Panarsky, Laura Bevilacqua, Rickard L Sjöberg, Jari Tiihonen, Matti Virkkunen
Herein, we examined insulin resistance (IR), insulin sensitivity (IS), beta cell activity, and glucose metabolism in subjects with antisocial personality disorder (ASPD), and whether the serotonin 2B (5-HT2B) receptor and testosterone have a role in energy metabolism. A cohort of subjects belonging to a founder population that included 98 ASPD males, aged 25-30, was divided into groups based on the presence of a heterozygous 5-HT2B receptor loss-of-function gene mutation (HTR2B Q20*; n = 9) or not (n = 89)...
October 2016: Journal of Psychiatric Research
S Bonnet, M Lacambre, A Schandrin, D Capdevielle, P Courtet
INTRODUCTION: Violence committed by individuals with severe mental illness has become an increasing focus of concern among clinicians, policy makers, and the general public, often as the result of tragic events. Research has shown in the past two decades an increased risk of violence among patients with mental disorder. Nevertheless, of those suffering from mental illness, perpetrators of other directed violence form a minority subgroup. The means by which there is this association between mental illness and violence has remained controversial...
May 20, 2016: L'Encéphale
Rachel V Smith, April M Young, Ursula L Mullins, Jennifer R Havens
PURPOSE: Examination of the association of antisocial personality disorder (ASPD) with substance use and HIV risk behaviors within the social networks of rural people who use drugs. METHODS: Interviewer-administered questionnaires were used to assess substance use, HIV risk behavior, and social network characteristics of drug users (n = 503) living in rural Appalachia. The MINI International Psychiatric Interview was used to determine whether participants met DSM-IV criteria for ASPD and Axis-I psychological comorbidities (eg, major depressive disorder, posttraumatic stress disorder, generalized anxiety disorder)...
May 12, 2016: Journal of Rural Health
Yoel Elizur, Lior Y Somech, Amiram D Vinokur
Callous-unemotional (CU) traits and effortful control (EC) are personality and temperament traits implicated in early-onset antisocial trajectories. This secondary analysis of Hitkashrut's randomized controlled trial first tested parent training's effects on EC and CU traits while controlling for more general treatment effects on conduct problems (CP), and subsequently tested mediation by parenting. Prekindergarten teachers in three Israeli cities identified 209 3-5 year-old (163 boys; 46 girls) preschoolers with subclinical-clinical range conduct problems...
May 5, 2016: Journal of Abnormal Child Psychology
Omer Faruk Demirel, Aysegul Demirel, Muhammed Tayyib Kadak, Murat Emül, Alaattin Duran
Neurological soft signs (NSS) were studied in some axis-I disorders like schizophrenia, obsessive compulsive disorder, bipolar disorder, alcohol and substance abuse disorder. Aim of this study is detection of neurological soft signs in antisocial personality disorder and relation of these signs with psychopathy. The study was included 41 antisocial men and 41 healthy control subjects. Sociodemographic form, neurological evaluation scale and Hare psychopathy checklist was applied to the antisocial subjects, whereas sociodemographic form and neurological evaluation scale were applied to the controls...
June 30, 2016: Psychiatry Research
Roger T Mulder, John Horwood, Peter Tyrer, Janet Carter, Peter R Joyce
AIM: The ICD-11 Personality Disorders Committee has proposed five personality domains: Detached, Anankastic, Negative Affective, Dissocial and Disinhibited. We attempted to validate these proposed domains in a large sample of patients with major depression. METHODS: Participants from five treatment studies received a SCID assessment interview to assess DSM-5 personality disorder symptoms. Personality disorder symptoms were assigned to the five proposed domains. Confirmatory factor analysis in an exploratory framework was used to test the hypothesized domain structure...
May 2016: Personality and Mental Health
John Newbury-Helps, Janet Feigenbaum, Peter Fonagy
This study was designed to test the hypothesis that individuals with antisocial, particularly violent, histories of offending behavior have specific problems in social cognition, notably in relation to accurately envisioning mental states. Eighty-three male offenders on community license, 65% of whom met the threshold for antisocial personality disorder (ASPD), completed a battery of computerized mentalizing tests requiring perspective taking (Perspectives Taking Test), mental state recognition from facial expression (Reading the Mind in the Eyes Test), and identification of mental states in the context of social interaction (Movie for the Assessment of Social Cognition)...
April 11, 2016: Journal of Personality Disorders
Luke W Hyde, Rebecca Waller, Christopher J Trentacosta, Daniel S Shaw, Jenae M Neiderhiser, Jody M Ganiban, David Reiss, Leslie D Leve
OBJECTIVE: Callous-unemotional behaviors in early childhood signal higher risk for trajectories of antisocial behavior and callous-unemotional traits that culminate in later diagnoses of conduct disorder, antisocial personality disorder, and psychopathy. Studies demonstrate high heritability of callous-unemotional traits, but little research has examined specific heritable pathways to early callous-unemotional behaviors. Studies also indicate that positive parenting protects against the development of callous-unemotional traits, but genetically informed designs have not been used to confirm that these relationships are not the product of gene-environment correlations...
September 1, 2016: American Journal of Psychiatry
Eila Repo-Tiihonen, Tero Hallikainen
Antisocial personality disorder (ASP), especially psychopathy as its extreme form, has provoked fear and excitement over thousands of years. Ruthless violence involved in the disorder has inspired scientists, too.The abundance of research results concerning epidemiology, physiology, neuroanatomy, heritability, and treatment interventions has made ASP one of the best documented disorders in psychiatry. Numerous interventions have been tested, but there is no current treatment algorithm. Biological and sociological parameters indicate the importance of early targeted interventions among the high risk children...
2016: Duodecim; Lääketieteellinen Aikakauskirja
L W Wesseldijk, G C Dieleman, R J L Lindauer, M Bartels, G Willemsen, J J Hudziak, D I Boomsma, C M Middeldorp
BACKGROUND: Spouses resemble each other for psychopathology, but data regarding spousal resemblance in externalizing psychopathology, and data regarding spousal resemblance across different syndromes (e.g. anxiety in wives and attention deficit/hyperactivity disorder [ADHD] in husbands) are limited. Moreover, knowledge is lacking regarding spousal resemblance in parents of children with psychiatric disorders. We investigated and compared spousal resemblance within and across internalizing and externalizing symptom domains in parents of children with and without psychopathology...
April 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
Woo-Young Ahn, Jasmin Vassileva
BACKGROUND: Recent animal and human studies reveal distinct cognitive and neurobiological differences between opiate and stimulant addictions; however, our understanding of the common and specific effects of these two classes of drugs remains limited due to the high rates of polysubstance-dependence among drug users. METHODS: The goal of the current study was to identify multivariate substance-specific markers classifying heroin dependence (HD) and amphetamine dependence (AD), by using machine-learning approaches...
April 1, 2016: Drug and Alcohol Dependence
Birgitte Thylstrup, Morten Hesse
Patients with antisocial personality disorder in outpatient treatment for substance use disorders are at high risk of drop-out. Using a randomized design, this study tested the impact of adding a brief psycho-educational program, the Impulsive Lifestyle Counseling program, to outpatient substance abuse treatment in order to prevent treatment dropout. Patients (N=175) were recruited from 13 municipal treatment centers in Denmark, and assigned to treatment as usual or to the experimental condition. In all, 172 patients could be included in the analyses...
June 2016: Addictive Behaviors
Hideki Miura, Yasuyuki Fuchigami
BACKGROUND: Several studies have suggested a relationship between cognitive impairment and recidivism, but most have adopted a retrospective design. AIM: The aim of this study was to test for any relationship between impaired executive function in adolescents with conduct disorder and subsequent recidivism up to 3 years later. METHOD: In this prospective cohort study, 221 male adolescents with conduct disorder, admitted to a juvenile justice assessment centre for the first time, were interviewed about their offence, age, onset of delinquency and family history...
February 10, 2016: Criminal Behaviour and Mental Health: CBMH
Julián Benito-León, Elan D Louis, Verónica Puertas-Martín, Juan Pablo Romero, Michele Matarazzo, José Antonio Molina-Arjona, Cristina Domínguez-González, Álvaro Sánchez-Ferro
INTRODUCTION: Evidence suggests that the cerebellum could play a role in the pathophysiology of orthostatic tremor. The link between orthostatic tremor and the cerebellum is of interest, especially in light of the role the cerebellum plays in cognition, and it raises the possibility that orthostatic tremor patients could have cognitive deficits consistent with cerebellar dysfunction. Our aim was to examine whether orthostatic tremor patients had cognitive deficits and distinct personality profiles when compared with matched controls...
February 15, 2016: Journal of the Neurological Sciences
Dorothy Y Y Tang, Amy C Y Liu, Simon S Y Lui, Bess Y H Lam, Bonnie W M Siu, Tatia M C Lee, Eric F C Cheung
Impairment in facial emotion perception is believed to be associated with aggression. Schizophrenia patients with antisocial features are more impaired in facial emotion perception than their counterparts without these features. However, previous studies did not define the comorbidity of antisocial personality disorder (ASPD) using stringent criteria. We recruited 30 participants with dual diagnoses of ASPD and schizophrenia, 30 participants with schizophrenia and 30 controls. We employed the Facial Emotional Recognition paradigm to measure facial emotion perception, and administered a battery of neurocognitive tests...
February 28, 2016: Psychiatry Research
Jennifer C Elliott, Malka Stohl, Melanie M Wall, Katherine M Keyes, Andrew E Skodol, Nicholas R Eaton, Dvora Shmulewitz, Renee D Goodwin, Bridget F Grant, Deborah S Hasin
BACKGROUND AND AIMS: Persistent cases of alcohol and nicotine dependence are associated with considerable morbidity and mortality, and are predicted by childhood maltreatment and personality disorders. Our aim was to test whether personality disorders (individually or conjointly) mediate the relationship between childhood maltreatment and the persistence of dependence. DESIGN: Personality disorders, modeled dimensionally, were tested as mediators of the relationship between childhood maltreatment and the 3-year persistence of alcohol and nicotine dependence in participants in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) who had current alcohol and nicotine dependence in their baseline interview...
May 2016: Addiction
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