keyword
MENU ▼
Read by QxMD icon Read
search

Evolution and tuberculosis

keyword
https://www.readbyqxmd.com/read/28337966/acid-fast-positive-and-acid-fast-negative-mycobacterium-tuberculosis-the-koch-paradox
#1
Catherine Vilchèze, Laurent Kremer
Acid-fast (AF) staining, also known as Ziehl-Neelsen stain microscopic detection, developed over a century ago, is even today the most widely used diagnostic method for tuberculosis. Herein we present a short historical review of the evolution of AF staining methods and discuss Koch's paradox, in which non-AF tubercle bacilli can be detected in tuberculosis patients or in experimentally infected animals. The conversion of Mycobacterium tuberculosis from an actively growing, AF-positive form to a nonreplicating, AF-negative form during the course of infection is now well documented...
March 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28320336/multidrug-resistant-tuberculosis-in-ethiopian-settings-and-its-association-with-previous-history-of-anti-tuberculosis-treatment-a-systematic-review-and-meta-analysis
#2
Setegn Eshetie, Mucheye Gizachew, Mulat Dagnew, Gemechu Kumera, Haile Woldie, Fekadu Ambaw, Belay Tessema, Feleke Moges
BACKGROUND: Efforts to control the global burden of tuberculosis (TB) have been jeopardized by the rapid evolution of multi-drug resistant Mycobacterium tuberculosis (MTB), which is resistant to at least isoniazid and rifampicin. Previous studies have documented variable prevalences of multidrug-resistant tuberculosis (MDR-TB) and its risk factors in Ethiopia. Therefore, this meta-analysis is aimed, firstly, to determine the pooled prevalence of MDR-TB among newly diagnosed and previously treated TB cases, and secondly, to measure the association between MDR-TB and a history of previous anti-TB drugs treatment...
March 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28275446/evolution-of-the-health-sector-response-to-hiv-in-myanmar-progress-challenges-and-the-way-forward
#3
EDITORIAL
Htun Nyunt Oo, San Hone, Masami Fujita, Amaya Maw-Naing, Krittayawan Boonto, Marjolein Jacobs, Sabe Phyu, Phavady Bollen, Jacquie Cheung, Htin Aung, May Thu Aung Sang, Aye Myat Soe, Razia Pendse, Eamonn Murphy
Critical building blocks for the response to HIV were made until 2012 despite a series of political, social and financial challenges. A rapid increase of HIV service coverage was observed from 2012 to 2015 through collaborative efforts of government and non-governmental organisations (NGOs). Government facilities, in particular, demonstrated their capacity to expand services for antiretroviral therapy (ART), prevention of mother-to-child transmission (PMTCT) of HIV, tuberculosis and HIV co-infection and methadone-maintenance therapy (MMT)...
November 28, 2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28246497/morbidity-by-tuberculosis-in-the-jiu-valley-relation-with-diagnostic-practice-and-the-impact-on-therapeutic-results
#4
Nicolae Petre, Daniela Homorodean, Carmen Monica Pop
BACKGROUND AND AIM: In the last two and a half decades the dynamics of tuberculosis has been modelled by social and economic conditions, with consequences on the life style, and effects on the onset and evolution of the disease. The Jiu Valley is an area with social problems: mining, mines closing down and ceasing activity, poverty. We looked for a relationship between changes of life style in the Jiu Valley and the dynamics of tuberculosis. METHODS: We studied 528 patients who asked for medical services in different hospitals in the Jiu Valley between 2010-2013...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28162798/-endobronchial-tuberculosis
#5
E Manal, Z Nahid, B Hanane, Y Najiba
BACKGROUND/AIM: The endobronchial tuberculosis (EBTB) is an uncommon type of tuberculosis. The respiratory symptoms in EBTB are usually nonspecific and misleading. The aim of the study is to determine the clinical features and diagnostic aspects of EBTB. PATIENTS AND METHODS: Twenty-eight cases of endobronchial tuberculosis collected from January 2009 to October 2015. RESULTS: EBTB was found in 16 females and 12 males. The mean age was 48 years...
February 2, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28159234/immunohistochemical-detection-of-pro-inflammatory-and-anti-inflammatory-cytokines-in-granulomas-in-cattle-with-natural-mycobacterium-bovis-infection
#6
Ana M Canal, Natalia Pezzone, Angel Cataldi, Martín Zumarraga, Mariano Larzabal, Sergio Garbaccio, Analía Fernandez, Lucas Dominguez, Alicia Aranaz, Antonio Rodriguez-Bertos
Cellular immune response was evaluated in lymph nodes and lung with different granulomatous lesions from cattle naturally infected with Mycobacterium bovis. For this purpose, we assessed pro-inflammatory and anti-inflammatory cytokines by immunohistochemical assays. Immunoreaction was observed for all the cytokines analyzed. Fourteen animals displayed advanced stage IV granulomas, with intense immunoreactivity to IFN-γ and TGF-β in areas of caseous necrosis, macrophages and lymphocytes. Seven animals showed stage III granuloma, with high immunoreactivity to IFN-γ (average of 44...
February 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28067906/prophage-mediated-defence-against-viral-attack-and-viral-counter-defence
#7
Rebekah M Dedrick, Deborah Jacobs-Sera, Carlos A Guerrero Bustamante, Rebecca A Garlena, Travis N Mavrich, Welkin H Pope, Juan C Cervantes Reyes, Daniel A Russell, Tamarah Adair, Richard Alvey, J Alfred Bonilla, Jerald S Bricker, Bryony R Brown, Deanna Byrnes, Steven G Cresawn, William B Davis, Leon A Dickson, Nicholas P Edgington, Ann M Findley, Urszula Golebiewska, Julianne H Grose, Cory F Hayes, Lee E Hughes, Keith W Hutchison, Sharon Isern, Allison A Johnson, Margaret A Kenna, Karen K Klyczek, Catherine M Mageeney, Scott F Michael, Sally D Molloy, Matthew T Montgomery, James Neitzel, Shallee T Page, Marie C Pizzorno, Marianne K Poxleitner, Claire A Rinehart, Courtney J Robinson, Michael R Rubin, Joseph N Teyim, Edwin Vazquez, Vassie C Ware, Jacqueline Washington, Graham F Hatfull
Temperate phages are common, and prophages are abundant residents of sequenced bacterial genomes. Mycobacteriophages are viruses that infect mycobacterial hosts including Mycobacterium tuberculosis and Mycobacterium smegmatis, encompass substantial genetic diversity and are commonly temperate. Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct prophage-expressed viral defence systems that interfere with the infection of lytic and temperate phages that are either closely related (homotypic defence) or unrelated (heterotypic defence) to the prophage...
January 9, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28062754/mycobacterium-tuberculosis-complex-exhibits-lineage-specific-variations-affecting-protein-ductility-and-epitope-recognition
#8
Inmaculada Yruela, Bruno Contreras-Moreira, Carlos Magalhães, Nuno S Osório, Jesús Gonzalo-Asensio
The advent of whole-genome sequencing has provided an unprecedented detail about the evolution and genetic significance of species-specific variations across the whole Mycobacterium tuberculosis Complex. However, little attention has been focused on understanding the functional roles of these variations in the protein coding sequences. In this work, we compare the coding sequences from 74 sequenced mycobacterial species including M. africanum, M. bovis, M. canettii, M. caprae, M. orygis, and M. tuberculosis Results show that albeit protein variations affect all functional classes, those proteins involved in lipid and intermediary metabolism and respiration have accumulated mutations during evolution...
January 6, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28053915/frequency-of-mutations-in-rifampicin-and-isoniazid-resistant-isolates-of-m-tuberculosis-an-analysis-from-central-india
#9
Prabha Desikan, Atul Kharate, Nikita Panwalkar, Jyoti Khurana, Shaina Beg Mirza, Aparna Chaturvedi, Reeta Varathe, Manju Chourey, Pradeep Kumar, Nitin Doshi, Manoj Pandey
BACKGROUND: The spread of drug-resistant tuberculosis has challenged tuberculosis control strategies globally. The present study aims to analyze the frequency of mutations in rpoB, katG and inhA genes in strains of M. tuberculosis complex (MTBC) circulating in Central India. It is anticipated that the findings may provide a starting point to understand the evolutionary success of drug-resistant strains of MTBC in this region. METHODS: Line probe assay was carried out on 720 consecutive sputum samples of MDR suspects from June 2012 to May 2013...
December 2016: Germs
https://www.readbyqxmd.com/read/28043788/comparison-of-bacteriological-conversion-and-treatment-outcomes-among-mdr-tb-patients-with-and-without-diabetes-in-mexico-preliminary-data
#10
M Muñoz-Torrico, J Caminero Luna, G B Migliori, L D'Ambrosio, J L Carrillo-Alduenda, H Villareal-Velarde, A Torres-Cruz, H Flores-Ergara, D Martínez-Mendoza, C García-Sancho, R Centis, M Á Salazar-Lezama, R Pérez-Padilla
Diabetes mellitus (DM) is a well-known risk factor for tuberculosis (TB). However, it is not known to what extent DM affects the outcome in patients with multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB) treated with second-line anti-TB drugs. The objective of this study was to compare the microbiological evolution (sputum smear and culture conversion) and final outcomes of MDR/XDR-TB patients with and without DM, managed at the national TB reference centre in Mexico City. RESULTS: Ninety patients were enrolled between 2010 and 2015: 73 with MDR-TB (81...
December 30, 2016: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28043592/next-generation-sequencing-based-user-friendly-platforms-for-drug-resistant-tuberculosis-diagnosis-a-promise-for-the-near-future
#11
David L Dolinger, Rebecca E Colman, David M Engelthaler, Timothy C Rodwell
Since 2002, there has been a gradual worldwide 1.3% annual decrease in the incidence of tuberculosis (TB). This is an encouraging statistic; however, it will not achieve the World Health Organization's goal of eliminating TB by 2050, and it is being compounded by the persistent global incidence of drug-resistant tuberculosis (DR-TB) acquired by transmission and by treatment pressure. One key to effectively control tuberculosis and the spread of multiresistant strains is accurate information pertaining to drug resistance and susceptibility...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043547/restriction-fragment-length-polymorphism-pattern-of-mycobacterium-isolates-from-rodents-in-infected-cattle-farms
#12
Khatereh Alizadeh, Nader Mosavari, Razieh Nazari
OBJECTIVE/BACKGROUND: Mycobacterium tuberculosis, the etiologic agent of tuberculosis, causes large-scale morbidity and mortality, particularly in developing countries. In recent years, there has been a significant increase in the drug-resistant ability of M. tuberculosis, triggering a major public health crisis. A detailed analysis of the evolution of the mycobacterial genome helps to better understand the genotype-phenotype relationship in this bacterium. Different strain typing methods have already revealed the worldwide diversity of mycobacterial isolates...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043520/molecular-characterization-of-mycobacterium-tuberculosis-strains-resistant-to-isoniazid
#13
Salma Smaoui, Mariem Siala, Sondes Hadj Fredj, Sana Kammoun, Chema Marouane, Salma Hachicha, Asma Ghorbel, Radhouane Gdoura, Leila Slim, Taieb Ben Messaoud, Férièle Messadi
OBJECTIVE/BACKGROUND: Tuberculosis is a major public health problem and the emergence of drug resistance complicates the situation even more. It is therefore crucial to implement all conclusions from the studies that aim at a better understanding of the molecular mechanisms which govern the emergence and the evolution of drug resistance. The aim of this study is to assess the degree of involvement of the inhA and katG genes in the acquisition of isoniazid resistance in clinical strains of Mycobacterium tuberculosis...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043498/multidrug-resistant-tuberculosis-in-ethiopian-settings-and-its-association-with-previous-antituberculosis-treatment-a-systematic-review-and-meta-analysis
#14
Setegn Eshetie, Feleke Moges, Mulat Dagnew
OBJECTIVES/BACKGROUND: Efforts to control the global burden of tuberculosis (TB) epidemic have now been jeopardized by the rapid evolution of drug-resistant Mycobacterium tuberculosis (MTB), which are resistant to one or more anti-TB drugs. Multidrug resistant (MDR) TB in Ethiopia may be more prevalent than previously appreciated; thus, up-to-date national drug resistance studies are critically needed. Therefore, this meta-analysis aimed, first, to determine pooled prevalence of MDR TB among newly diagnosed and previously treated TB cases, and second, to measure the association between previous anti-TB exposure and acquisition of MDR-MTB infection...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28007659/retrospective-study-of-clinical-and-lesion-characteristics-of-patients-undergoing-surgical-treatment-for-pulmonary-tuberculosis-in-georgia
#15
REVIEW
Sergo Vashakidze, Albert Despuig, Shota Gogishvili, Keti Nikolaishvili, Natalia Shubladze, Zaza Avaliani, Nestan Tukvadze, Martí Casals, Joan A Caylà, Pere-Joan Cardona, Cristina Vilaplana
OBJECTIVES: Our aim was to retrospectively compare clinical data and characteristics of removed lesions of the cohort of patients undergoing therapeutical surgery for their tuberculosis. DESIGN AND METHODS: Demographic and epidemiological details, clinical data, data on the surgery performed, macroscopic characteristics of the TB lesions removed, and outcome were recorded retrospectively from the 137 patients who underwent therapeutical surgery for their TB in Tbilisi, Georgia during 2014 and 2015...
December 19, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28005986/a-systematic-review-of-cost-effectiveness-studies-reporting-cost-per-daly-averted
#16
Peter J Neumann, Teja Thorat, Yue Zhong, Jordan Anderson, Megan Farquhar, Mark Salem, Eileen Sandberg, Cayla J Saret, Colby Wilkinson, Joshua T Cohen
INTRODUCTION: Calculating the cost per disability-adjusted life years (DALYs) averted associated with interventions is an increasing popular means of assessing the cost-effectiveness of strategies to improve population health. However, there has been no systematic attempt to characterize the literature and its evolution. METHODS: We conducted a systematic review of cost-effectiveness studies reporting cost-per-DALY averted from 2000 through 2015. We developed the Global Health Cost-Effectiveness Analysis (GHCEA) Registry, a repository of English-language cost-per-DALY averted studies indexed in PubMed...
2016: PloS One
https://www.readbyqxmd.com/read/27998327/entangled-histories-german-veterinary-medicine-c-1770-1900
#17
Tatsuya Mitsuda
Medical historians have recently become interested in the veterinary past, investigating the development of animal health in countries such as France, the Netherlands, the United Kingdom and the United States. An appreciation of the German context, however, is still lacking - a gap in the knowledge that the present article seeks to fill. Providing a critical interpretation of the evolution of the veterinary profession, this investigation explains why veterinary and medical spheres intersected, drifted apart, then came back together; it also accounts for the stark differences in the position of veterinarians in Germany and Britain...
January 2017: Medical History
https://www.readbyqxmd.com/read/27997216/transmissible-mycobacterium-tuberculosis-strains-share-genetic-markers-and-immune-phenotypes
#18
Hanna Nebenzahl-Guimaraes, Arjan van Laarhoven, Maha R Farhat, Valerie Acm Koeken, Jornt J Mandemakers, Aldert Zomer, Sacha Aft van Hijum, Mihai G Netea, Megan Murray, Reinout van Crevel, Dick van Soolingen
RATIONALE: Successful transmission of tuberculosis depends on the interplay of human behavior, host immune responses and Mycobacterium tuberculosis virulence factors. Previous studies have focused on identifying host risk factors associated with increased transmission, while the contribution of specific genetic variations in mycobacterial strains themselves are still unknown. OBJECTIVES: To identify mycobacterial genetic markers associated with increased transmissibility, and examine whether these markers lead to altered in vitro immune responses...
December 20, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27973588/within-host-evolution-selects-for-a-dominant-genotype-of-mycobacterium-tuberculosis-while-t-cells-increase-pathogen-genetic-diversity
#19
Richard Copin, Xueying Wang, Eddie Louie, Vincent Escuyer, Mireia Coscolla, Sebastien Gagneux, Guy H Palmer, Joel D Ernst
Molecular epidemiological assessments, drug treatment optimization, and development of immunological interventions all depend on understanding pathogen adaptation and genetic variation, which differ for specific pathogens. Mycobacterium tuberculosis is an exceptionally successful human pathogen, yet beyond knowledge that this bacterium has low overall genomic variation but acquires drug resistance mutations, little is known of the factors that drive its population genomic characteristics. Here, we compared the genetic diversity of the bacteria that established infection to the bacterial populations obtained from infected tissues during murine M...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27959952/experimental-evolution-of-mycobacterium-tuberculosis-in-human-macrophages-results-in-low-frequency-mutations-not-associated-with-selective-advantage
#20
Valentina Guerrini, Selvakumar Subbian, Pierre Santucci, Stéphane Canaan, Maria Laura Gennaro, Gianni Pozzi
Isolates of the human pathogen Mycobacterium tuberculosis recovered from clinical samples exhibit genetic heterogeneity. Such variation may result from the stressful environment encountered by the pathogen inside the macrophage, which is the host cell tubercle bacilli parasitize. To study the evolution of the M. tuberculosis genome during growth inside macrophages, we developed a model of intracellular culture in which bacteria were serially passaged in macrophage-like THP-1 cells for about 80 bacterial generations...
2016: PloS One
keyword
keyword
62054
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"