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https://www.readbyqxmd.com/read/28636892/topical-bioavailability-of-diclofenac-from-locally-acting-dermatological-formulations
#1
S F Cordery, A Pensado, W S Chiu, M Z Shehab, A L Bunge, M B Delgado-Charro, R H Guy
Assessment of the bioavailability of topically applied drugs designed to act within or beneath the skin is a challenging objective. A number of different, but potentially complementary, techniques are under evaluation. The objective of this work was to evaluate in vitro skin penetration and stratum corneum tape-stripping in vivo as tools with which to measure topical diclofenac bioavailability from three approved and commercialized products (two gels and one solution). Drug uptake into, and its subsequent clearance from, the stratum corneum of human volunteers was used to estimate the input rate of diclofenac into the viable skin layers...
June 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28636822/electrochemical-properties-and-speciation-in-mg-hmds-2-based-electrolytes-for-magnesium-ion-batteries-as-a-function-of-ethereal-solvent-type-and-temperature
#2
Laura C Merrill, Jennifer L Schaefer
Magnesium batteries are a promising alternative to lithium-ion batteries due to the widespread abundance of magnesium and its high specific volumetric energy capacity. Ethereal solvents such as tetrahydrofuran (THF) are commonly used for magnesium-ion electrolytes due the chemical compatibility with magnesium metal, but the volatile nature of THF is a concern for practical application. Herein, we investigate magnesium bis(hexamethyldisilazide) plus aluminum chloride (Mg(HMDS)2-AlCl3) electrolytes in THF, diglyme, and tetraglyme at varying temperature...
June 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28636324/oxide-film-efficiently-suppresses-dendrite-growth-in-aluminum-ion-battery
#3
Hao Chen, Hanyan Xu, Bingna Zheng, Siyao Wang, Tieqi Huang, Fan Guo, Weiwei Gao, Chao Gao
Aluminum metal foil is the optimal choice as an anode material for aluminum-ion battery for its key advantages such as high theoretical capacity, safety and low cost. However, the metallic nature of aluminum foil is very likely to induce severe dendrite growth with further electrode disintegration and cell failure, which is inconsistent with the previous reports. Here, we discover that it is aluminum oxide film that efficiently restricts the growth of crystalline Al dendrite and thus improves the cycling stability of Al anode...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28636029/cross-impact-of-surface-and-interaction-anisotropy-in-the-self-assembly-of-organic-adsorption-monolayers-a-monte-carlo-and-transfer-matrix-study
#4
V A Gorbunov, S S Akimenko, A V Myshlyavtsev
Using a simple lattice gas model we study the features of self-assembly in adsorption layers where both "molecule-surface" and "molecule-molecule" interactions are anisotropic. Based on the example of adsorption layers of mono-functional organic molecules on the heterogeneous surface with strip-like topography, we have revealed plenty of possible self-assembled structures in this simple system, such as discrete, linear, zigzag, chess board-like, two-dimensional porous and close-packed patterns. However, the phase behavior of the adsorption layer is much richer, if the interactions between functional and non-functional parts of adjacent adsorbed molecules have comparable strength and opposite signs...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28634555/a-rare-case-of-pneumopericardium-in-the-setting-of-tuberculous-constrictive-pericarditis
#5
Lauro L Abrahan Iv, Stephanie Martha O Obillos, Jaime Alfonso M Aherrera, Jose Donato A Magno, Celia Catherine C Uy-Agbayani, Ulysses King G Gopez, Jobelle Joyce Anne R Baldonado
A 28-year-old Filipino male was admitted due to high-grade fevers and dyspnea on a background of chronic cough and weight loss. Due to clinical and echocardiographic signs of cardiac tamponade, emergency pericardiocentesis was performed on his first hospital day. Five days after, chest radiographs showed new pockets of radiolucency within the cardiac shadow, indicative of pneumopericardium. On repeat echo, air microbubbles admixed with loculated effusion were visualized in the anterior pericardial space. Constrictive physiology was also supported by a thickened pericardium, septal bounce, exaggerated respiratory variation in AV valve inflow, and IVC plethora...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28632156/image-mosaicking-approach-for-a-double-camera-system-in-the-gaofen2-optical-remote-sensing-satellite-based-on-the-big-virtual-camera
#6
Yufeng Cheng, Shuying Jin, Mi Wang, Ying Zhu, Zhipeng Dong
The linear array push broom imaging mode is widely used for high resolution optical satellites (HROS). Using double-cameras attached by a high-rigidity support along with push broom imaging is one method to enlarge the field of view while ensuring high resolution. High accuracy image mosaicking is the key factor of the geometrical quality of complete stitched satellite imagery. This paper proposes a high accuracy image mosaicking approach based on the big virtual camera (BVC) in the double-camera system on the GaoFen2 optical remote sensing satellite (GF2)...
June 20, 2017: Sensors
https://www.readbyqxmd.com/read/28631828/development-of-a-colloidal-gold-immunochromatographic-assay-gica-for-the-rapid-detection-of-spiroplasma-eriocheiris-in-commercially-exploited-crustaceans-from-china
#7
H Liu, Y Xiu, Y Xu, M Tang, S Li, W Gu, Q Meng, W Wang
Spiroplasma eriocheiris is an emerging pathogen in freshwater crustaceans. In recent years, Eriocheir sinensis, Procambarus clarkii, Litopenaeus vannamei, Macrobrachium rosenbergii and Macrobrachium nipponense had been infected by this pathogen in China. An immunochromatographic strip test using gold nanoparticles was developed for rapidly detecting this pathogen. The strip test based on the principle of sandwich immunoassay by the specific combination between the pathogen and polyclonal antibody on a nitrocellulose membrane...
June 20, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28631534/measuring-well-being-in-israel-and-palestine
#8
Guido Veronese, Alessandro Pepe, Jamal Dagdouke, Loredana Addimando, Shaher Yagi
This work presents the psychometric properties of the Subjective Well-Being Assessment Scale in a sample of 423 participants composed of Israeli Arabs and Palestinians from the West Bank/Gaza Strip. Psychometric assessment of the instrument was based on confirmatory factor analysis. The convergent and discriminant validity of Subjective Well-Being Assessment Scale were also tested via administration of the General Health Questionnaire and the Positive and Negative Affect Scale. The results suggest that Subjective Well-Being Assessment Scale is valid, reliable, and solid from a psychometric point of view and provides an accurate assessment of respondents' well-being...
January 1, 2017: Psychological Reports
https://www.readbyqxmd.com/read/28631090/subclinical-cutaneous-inflammation-remained-after-permeability-barrier-disruption-enhances-uv-sensitivity-by-altering-er-stress-responses-and-topical-pseudoceramide-prevents-them
#9
Sang Eun Lee, Yutaka Takagi, Takahiro Nishizaka, Ji Hwoon Baek, Han Jo Kim, Seung Hun Lee
Stratum corneum forms the UV barrier. The effect of ultraviolet B (UVB) on normal skin was extensively studied; however, its effect on barrier perturbed skin remains undefined. Both barrier perturbation and UVB irradiation induce endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in keratinocytes. Mild ER stress activates homeostatic UPR, while severe ER stress leads to abnormal UPR, promoting apoptosis and inflammation. Here, we investigated UV sensitivity and UVB-induced UPR in barrier-disrupted human skin and the effects of pseudoceramide-dominant emollient on UVB-induced skin responses...
June 19, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28630857/effectiveness-of-a-commercial-lactic-acid-bacteria-intervention-applied-to-inhibit-shiga-toxin-producing-escherichia-coli-on-refrigerated-vacuum-aged-beef
#10
Katie R Kirsch, Tamra N Tolen, Jessica C Hudson, Alejandro Castillo, Davey Griffin, T Matthew Taylor
Because of their antagonistic activity towards pathogenic and spoilage bacteria, some members of the lactic acid bacteria (LAB) have been evaluated for use as food biopreservatives. The objectives of this study were to assess the antimicrobial utility of a commercial LAB intervention against O157 and non-O157 Shiga-toxigenic E. coli (STEC) on intact beef strip loins during refrigerated vacuum aging and determine intervention efficacy as a function of mode of intervention application. Prerigor strip loins were inoculated with a cocktail (8...
2017: International journal of food science
https://www.readbyqxmd.com/read/28630840/suspension-arthroplasty-combined-with-ligament-reconstruction-of-the-thumb-carpometacarpal-joint-to-salvage-two-failed-arthroplasties-a-case-report
#11
Ryosuke Kakinoki, Kazuhiko Hashimoto, Hiroki Tanaka, Masao Akagi
INTRODUCTION: Thumb basal joint arthroplasty with removal of the entire trapezium is often followed by proximal subsidence and impingement of the thumb metacarpal to the scaphoid, which is a common cause of post-operative thumb pain. Treatment of this impingement is a challenge among surgeons. We performed suspension arthroplasty combined with intercarpal ligament reconstruction using a strip of the extensor carpi radialis longus (ECRL) tendon on a patient suffering from pain caused by this type of the impingement and obtained a successful outcome...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630790/rehabilitation-of-eyelid-malpositions-secondary-to-facial-palsy
#12
Şeyda Karadeniz Uğurlu, Mustafa Karakaş
OBJECTIVES: To evaluate patient satisfaction and outcomes of surgical treatment of eyelid malpositions secondary to facial palsy. MATERIALS AND METHODS: Consecutive patients with facial palsy who underwent surgical treatment by the same surgeon at İzmir Katip Çelebi University Atatürk Training and Research Hospital between Jan 2007 and Dec 2012 were included in the study. Ophthalmic examination findings, surgical approaches, and their outcomes were evaluated...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28630410/investigating-the-life-expectancy-and-proteolytic-degradation-of-engineered-skeletal-muscle-biological-machines
#13
Caroline Cvetkovic, Meghan C Ferrall-Fairbanks, Eunkyung Ko, Lauren Grant, Hyunjoon Kong, Manu O Platt, Rashid Bashir
A combination of techniques from 3D printing, tissue engineering and biomaterials has yielded a new class of engineered biological robots that could be reliably controlled via applied signals. These machines are powered by a muscle strip composed of differentiated skeletal myofibers in a matrix of natural proteins, including fibrin, that provide physical support and cues to the cells as an engineered basement membrane. However, maintaining consistent results becomes challenging when sustaining a living system in vitro...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629017/design-of-a-new-nanocomposite-between-bismuth-nanoparticles-and-graphene-oxide-for-development-of-electrochemical-sensors
#14
Eduardo H Bindewald, Arthur F Schibelbain, Maurício A P Papi, Eduardo G C Neiva, Aldo J G Zarbin, Márcio F Bergamini, Luiz H Marcolino-Júnior
This study describes a new route for preparation of a nanocomposite between graphene oxide (GO) and bismuth nanoparticles (BiNPs) and its evaluation as modifier electrode for development of electrochemical sensors. BiNPs were synthesized under ultrasound conditions using Bi(NO3)3 as metal precursor and ascorbic acid (AA) as reducing agent/passivating. Some experimental parameters of BiNPs synthesis such as Bi(3+):AA molar ratio and reaction time were conducted aiming the best voltammetric performance of the sensor...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628812/modelling-water-and-nutrient-fluxes-in-the-danube-river-basin-with-swat
#15
REVIEW
Anna Malagó, Faycal Bouraoui, Olga Vigiak, Bruna Grizzetti, Marco Pastori
This study provides an innovative process-based modelling approach using the SWAT model and shows its application to support the implementation of the European environmental policies in large river basins. The approach involves several pioneering modelling aspects: the inclusion of current management practices; an innovative calibration and validation methodology of streamflow and water quality; a sequential calibration starting from crop yields, followed by streamflow and nutrients; and the use of concentrations instead of loads in the calibration...
June 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28628008/basophil-histamine-release-to-amoxicilloyl-poly-l-lysine-compared-to-amoxicillin-in-patients-with-ige-mediated-allergic-reactions-to-amoxicillin
#16
F Arribas, S Falkencrone, J Sola, M P Gomez-Serranillos, J J Laguna, M I Montañez, T D Fernandez, D Rodríguez, F Pineda, P Stahl Skov, C Mayorga, M J Torres
BACKGROUND: Amoxicillin (AX) is the betalactam most often involved in IgE-mediated reactions and the diagnosis is mainly based on skin testing (ST) although without optimal sensitivity. We have produced a newly AX derivative, amoxicilloyl-poly-L-lysine (APL), and have analysed its IgE recognition by passive histamine release test (pHRT). METHODS: Patients (N=19) with confirmed AX allergy and with specific IgE positive to AX and controls (N=10) with good tolerance to AX were included...
June 19, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28627603/role-of-stem-cell-factor-in-the-regulation-of-icc-proliferation-and-detrusor-contraction-in-rats-with-an-underactive-bladder
#17
Jianli Feng, Jin Gao, Shan Zhou, Yuanfeng Liu, Yu Zhong, Yong Shu, Ming Sen Meng, Jiaqiang Yan, Danning Sun, Qiang Fang, Daodong Sun
Stem cell factor (SCF) is critical in regulating the proliferation, differentiation and function of the interstitial cells of Cajal (ICCs), which are closely associated with smooth muscle dysfunction. The present study aimed to examine the effect of SCF on ICC proliferation and detrusor contraction in rats with an underactive bladder. Sprague‑Dawley rats were divided into four groups comprising control, control+SCF, detrusor underactivity (DU), and DU+SCF groups. The ICC count was determined using immunofluorescence; serum levels of SCF were determined using an enzyme‑linked immunosorbent assay; mRNA and protein levels of c‑kit and SCF in tissues were assessed using reverse transcription‑quantitative polymerase chain reaction and western blot analyses, respectively...
June 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627004/utility-of-the-urine-reagent-strip-leukocyte-esterase-assay-for-the-diagnosis-of-meningitis-in-resource-limited-settings-meta-analysis
#18
REVIEW
William Bortcosh, Mark Siedner, Ryan W Carroll
OBJECTIVE: Diagnosis of bacterial meningitis often requires cytometry, chemistry, and/or microbiologic culture capabilities. Unfortunately, laboratory resources in low resource settings (LRS) often lack the capacity to perform these studies. We sought to determine whether the presence of white blood cells in CSF detected by commercially available urine reagent strips could aid in the diagnosis of bacterial meningitis. METHODS: We searched PubMed for studies published between 1980 - 2016 that investigated the use of urine reagent strips to identify cerebrospinal fluid (CSF) pleocytosis...
June 19, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28626566/functional-metal-organic-framework-boosting-lithium-metal-anode-performance-via-chemical-interactions
#19
Wen Liu, Yingying Mi, Zhe Weng, Yiren Zhong, Zishan Wu, Hailiang Wang
Dendrite growth and low coulombic efficiency are two major factors that limit the utilization of Li metal electrodes in future generations of high-energy-density rechargeable batteries. This article reports the first study on metal-organic framework (MOF) materials for boosting the electrochemical performance of Li metal electrodes and demonstrates the power of molecular-structure functionalization for realizing desirable ion transport and Li metal nucleation and growth. We show that dendrite-free dense Li deposition and stable Li plating/stripping cycling with high coulombic efficiency are enabled by modifying a commercial polypropylene separator with a titanium-based MOF (NH2-MIL-125(Ti)) material...
June 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28626281/measurement-of-uranium-236-in-particles-by-secondary-ion-mass-spectrometry
#20
David S Simons, John D Fassett
The determination of the relative isotopic abundance by secondary ion mass spectrometry of (236)U in uranium-containing material is complicated by the presence of (235)U(1)H(+) ions at the same nominal mass as the uranium isotopic peak. The net intensity of the (236)U signal is usually determined by a peak-stripping procedure, whereby the (235)U(1)H(+) contribution is obtained by applying the (238)U(1)H(+)/(238)U(+) ratio to the (235)U(+) signal. The subtraction of one signal from another has consequences for the uncertainty of the final (236)U abundance determination that may be especially significant when the amount of sample is limited, as is the case with small uranium particles that are of great interest for nuclear safeguards...
February 2017: Journal of Analytical Atomic Spectrometry
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