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https://www.readbyqxmd.com/read/28734358/fluorescent-quenching-immune-chromatographic-strips-with-quantum-dots-and-upconversion-nanoparticles-as-fluorescent-donors-for-visual-detection-of-sulfaquinoxaline-in-foods-of-animal-origin
#1
Gaoshuang Hu, Wei Sheng, Jingmin Li, Yan Zhang, Junping Wang, Shuo Wang
In this study, two novel fluorescence quenching immune chromatographic strips (FQICS) were developed to detect sulfaquinoxaline (SQX) in foods of animal origin. These proposed FQICSs were based on fluorescence resonance energy transfer (FRET) from fluorescence donors (quantum dots or upconversion nanoparticles) to fluorescence acceptors (colloidal gold nanoparticles). Compared with traditional colloidal gold-based immune chromatographic strips (ICS), these FQICSs showed positive correlation between the fluorescent signals and the targets, and allowed user to get test results from weak fluorescent signals...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28733893/effects-of-new-generation-tmem16a-inhibitors-on-calcium-activated-chloride-currents-in-rabbit-urethral-interstitial-cells-of-cajal
#2
Stephen Fedigan, Eamonn Bradley, Timothy Webb, Roddy J Large, Mark A Hollywood, Keith D Thornbury, Noel G McHale, Gerard P Sergeant
Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit Ca(2+)-activated Cl(-) currents (I ClCa) that are important for the development of urethral tone. Here, we examined if TMEM16A (ANO1) contributed to this activity by examining the effect of "new-generation" TMEM16A inhibitors, CACCinh-A01 and T16Ainh-A01, on I ClCa recorded from freshly isolated rabbit urethral ICC (RUICC) and on contractions of intact strips of rabbit urethra smooth muscle. Real-time quantitative PCR experiments demonstrated that TMEM16A was highly expressed in rabbit urethra smooth muscle, in comparison to TMEM16B and TMEM16F...
July 21, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28733683/radiation-loss-of-planar-surface-plasmon-polaritons-transmission-lines-at-microwave-frequencies
#3
Zhixia Xu, Shunli Li, Xiaoxing Yin, Hongxin Zhao, Leilei Liu
Radiation loss of a typical spoof surface plasmon polaritons (SSPPs) transmission line (TL) is investigated in this paper. A 325 mm-long SSPPs TL is designed and fabricated. Simulated results show that radiation loss contributes more to transmission loss than dielectric loss and conductor loss from 2 GHz to 10 GHz. Radiation loss of the SSPPs TL could be divided into two parts, one is caused by the input mode converter, and the other is caused by the corrugated metallic strip. This paper explains mechanisms of radiation loss from different parts, designs a loaded SSPPs TL with a series of resistors to absorb electromagnetic energy on corrugated metallic strip, and then discriminates radiation loss from the input mode converter, proposes the concept of average radiation length (ARL) to evaluate radiation loss from SSPPs of finite length, and concludes that radiation loss is mainly caused by corrugated structure of finite length at low frequency band and by the input mode converter at high frequency band...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732398/simulation-of-targeted-pollutant-mitigation-strategies-to-reduce-nitrate-and-sediment-hotspots-in-agricultural-watershed
#4
Awoke Dagnew Teshager, Philip W Gassman, Silvia Secchi, Justin T Schoof
About 50% of U.S. water pollution problems are caused by non-point source (NPS) pollution, primarily sediment and nutrients from agricultural areas, despite the widespread implementation of agricultural Best Management Practices (BMPs). However, the effectiveness of implementation strategies and type of BMPs at watershed scale are still not well understood. In this study, the Soil and Water Assessment Tool (SWAT) ecohydrological model was used to assess the effectiveness of pollutant mitigation strategies in the Raccoon River watershed (RRW) in west-central Iowa, USA...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28731432/multivariate-approach-for-alzheimer-s-disease-detection-using-stationary-wavelet-entropy-and-predator-prey-particle-swarm-optimization
#5
Yudong Zhang, Shuihua Wang, Yuxiu Sui, Ming Yang, Bin Liu, Hong Cheng, Junding Sun, Wenjuan Jia, Preetha Phillips, Juan Manuel Gorriz
BACKGROUND: The number of patients with Alzheimer's disease is increasing rapidly every year. Scholars often use computer vision and machine learning methods to develop an automatic diagnosis system. OBJECTIVE: In this study, we developed a novel machine learning system that can make diagnoses automatically from brain magnetic resonance images. METHODS: First, the brain imaging was processed, including skull stripping and spatial normalization...
July 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731352/exploiting-the-marangoni-effect-to-initiate-instabilities-and-direct-the-assembly-of-liquid-metal-filaments
#6
Christopher A Hartnett, Ivana Seric, Kyle Mahady, Lou Kondic, Shahriar Afkhami, Jason Fowlkes, Philip D Rack
The utilization of the Marangoni effect in a liquid metal is investigated, focusing on initiating instabilities to direct material assembly via the Rayleigh-Plateau instability. Thin (2 nm) copper (Cu) films are lithographically patterned onto thick (12 nm) nickel (Ni) strips to induce a surface energy gradient at the maximum wavelength of the filament instability predicted by Rayleigh-Plateau instability analysis. The pattern is irradiated with an 18 ns pulsed-laser such that the pattern melts and the resultant Ni-Cu surface tension gradient induces Marangoni flows due to the difference in surface energies...
July 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28730750/improving-type-2-diabetes-mellitus-glycaemic-outcomes-is-possible-without-spending-more-on-medication-lessons-from-the-uk-national-diabetes-audit
#7
Adrian H Heald, Mark Livingston, Nagaraj Malipatil, Michal Becher, Joyce Craig, Mike Stedman, Anthony A Fryer
OBJECTIVES: There is continuing discussion globally about how to optimise outcomes for type 2 diabetes (T2DM) patients. In the UK, national (NICE) guidance was updated in 2016 (NG28). We aimed to determine the factors at a GP practice level that relate to glycaemic control outcome. METHODS: Data was accessed from 4,050 GP practices (GPP) (50% of total) covering 1.6 million T2DM patients in the UK National Diabetes Audit 2013-14 and 2014-15. This reported T2DM population characteristics, services and outcomes, including % total glycaemic control (TGC) (at 67...
July 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28730311/aptamer-based-fluorescence-quenching-lateral-flow-strip-for-rapid-detection-of-mercury-ii-ion-in-water-samples
#8
Ze Wu, Haicong Shen, Junhui Hu, Qiangqiang Fu, Cuize Yao, Shiting Yu, Wei Xiao, Yong Tang
Divalent mercury ion (Hg(2+)) is one of the most common and stable forms of mercury pollution. In this study, a skillfully designed lateral flow strip (LFS) was developed for sensitive detection of Hg(2+) in river water samples. Aptamer, a specific oligonucleotide probe, was used to selectively identify and target Hg(2+) instead of antibody in traditional immunechromatographic strips; and the fluorescence-quenching system was used to generate positive and low background florescence signals in the competitive-likely LFS...
July 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28730110/incidence-of-cystoid-macular-edema-after-descemet-s-stripping-automated-endothelial-keratoplasty
#9
Eduard Pedemonte-Sarrias, Toni Salvador Playà, Irene Sassot Cladera, Oscar Gris, Joan Ribas Martínez, José García-Arumí, Núria Giménez
AIM: To determine the incidence of cystoid macular edema (CME) after Descemet's stripping automated endothelial keratoplasty (DSAEK). METHODS: This study included all consecutive patients operated in a Spanish tertiary reference hospital over a period of four years. A total of 55 eyes from 47 patients matched the selection criteria. CME was diagnosed clinically at the slit-lamp and confirmed by optical coherence tomography. RESULTS: Six cases of CME were diagnosed postoperatively, which represented an incidence of 11%...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28728288/-descemet-s-membrane-endothelial-keratoplasty-for-treatment-of-patients-with-corneal-endothelial-decompensation
#10
T Huang, C Ouyang, J Zhan, L Jiang
Objective: To evaluate the clinical outcomes of Descemet's membrane endothelial keratoplasty (DMEK) for treatment of patients with corneal endothelial decompensation in China. Methods: Interventional case series. Ten patients (10 eyes) with the diagnosis of corneal endothelial decompensation received DMEK during July 2016 and September 2016 in Zhongshan Ophthalmic Center. Descemet's membrane of the donor tissue was carefully stripped from the underlying stroma manually and cut with a 7.75- or 8.0-mm-diameter donor punch...
July 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28727955/longitudinal-child-oriented-dietary-intervention-association-with-parental-diet-and-cardio-metabolic-risk-factors-the-special-turku-coronary-risk-factor-intervention-project
#11
Johanna M Jaakkola, Katja Pahkala, Tapani Rönnemaa, Jorma Viikari, Harri Niinikoski, Eero Jokinen, Hanna Lagström, Antti Jula, Olli Raitakari
Background The child-oriented dietary intervention given in the prospective Special Turku Coronary Risk Factor Intervention Project (STRIP) has decreased the intake of saturated fat and lowered serum cholesterol concentration in children from infancy until early adulthood. In this study, we investigated whether the uniquely long-term child-oriented intervention has affected also secondarily parental diet and cardio-metabolic risk factors. Methods The STRIP study is a longitudinal, randomized infancy-onset atherosclerosis prevention trial continued from the child's age of 8 months to 20 years...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28724814/comparison-of-intraocular-pressure-measurements-using-goldmann-tonometer-i-care-pro-tonopen-xl-and-schiotz-tonometer-in-patients-after-descemet-stripping-endothelial-keratoplasty
#12
Oded Ohana, David Varssano, Gabi Shemesh
PURPOSE: Post-Descemet stripping endothelial keratoplasty (DSEK) patients are prone for intraocular pressure (IOP) elevations and glaucoma. Corneal characteristics influence various IOP measuring devices in various ways. The aim of this study was to evaluate the agreement between four different IOP measuring devices: Goldmann applanation tonometer (GAT), I-care pro, Tonopen XL, and Schiotz tonometr in patients who underwent DSEK. METHODS: This was a prospective comparative study using a convenience cohort of post-DSEK patients with compact grafts...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28723590/cardioprotective-mitochondrial-binding-by-hexokinase-i-is-induced-by-a-hyperoxic-acute-thermal-insult-in-the-rainbow-trout-oncorhynchus-mykiss
#13
Neal Ingraham Callaghan, Kenneth Javier Williams, Tyson James MacCormack
Due to the substantial photosynthetic biomass in their habitat, salmonids such as the rainbow trout (Oncorhynchus mykiss) can be subject to hyperoxia in addition to high temperatures associated with climate change. Both stressful conditions increase the incidence of damaging reactive oxygen species (ROS). The mitochondrial association of hexokinase has been shown to increase in the hearts of certain fish experiencing hypoxia in a putative cardioprotective response to oxidative stress. In this study, the mitochondrial association of hexokinase I (HKI) and markers of oxidative damage and metabolic stress were probed to elucidate the cardioprotective role of hexokinase in the rainbow trout...
July 16, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28723195/lanthanide-labeled-immunochromatographic-strip-assay-for-the-on-site-identification-of-ancient-silk
#14
Qiushi You, Miaomiao Liu, Yang Liu, Hailing Zheng, Zhiwen Hu, Yang Zhou, Bing Wang
The on-site identification of ancient silks has long been a key challenge in archeology. Therefore, a rapid, cost-effective, sensitive analytical approach is highly desirable. In this paper, a lanthanide-labeled immunochromatographic strip which is suitable for the on-site identification of ancient silks is described. Compared with the conventional colloidal gold-based immunochromatographic strip, this strip shows much higher analytical sensitivity and better quantitative discrimination. The limit of detection (LOD) of the strip for silk fibroin (SF) was calculated as 8...
April 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723127/fluorescent-chemosensors-with-varying-degrees-of-intramolecular-charge-transfer-for-detection-of-a-nerve-agent-mimic-in-solutions-and-in-vapor
#15
Yuan-Chao Cai, Chen Li, Qin-Hua Song
Nerve agents are highly toxic organophosphorus compounds, and their possible use in terrorist attacks has led to increasing interest in the development of reliable and accurate methods to detect these lethal chemicals. In this paper, we have prepared six 6-aminoquinolines with various N-substituents as chemosensors for a nerve-agent mimic diethylchlorophosphate (DCP). The chemosensors with the nucleophilic pyridine-N atom as the active site detect DCP via a catalytic hydrolysis approach to form the protonated sensor...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28723110/portable-sensor-for-the-detection-of-choline-and-its-derivatives-based-on-silica-isoporous-membrane-and-gellified-nanointerfaces
#16
Lisiqi Xie, Xiao Huang, Bin Su
A portable amperometric ion sensor was fabricated by integrating silica isoporous membrane (SIM) and organogel composed of polyvinyl chloride and 1,2-dichloroethane (PVC-DCE) on a 3D-printed polymer chip. The detection of ionic species in aqueous samples could be accomplished by adding a microliter of sample droplet to the sensor and by identifying the ion-transfer potential and current magnitude at the water/organogel interface array templated by SIM. Thanks to the ultrasmall channel size (2-3 nm in diameter), high channel density (4 × 10(8) μm(-2)), and ultrathin thickness (80 nm) of SIM, the ensemble of nanoscopic water/organogel (nano-W/Gel) interface array behaved like a microinterface with two back-to-back hemispherical mass diffusion zones...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721650/prediction-of-pulmonary-metastasis-in-pulmonary-nodules-%C3%A2-10%C3%A2-mm-detected-in-patients-with-primary-extrapulmonary-malignancy-at-thin-section-staging-ct
#17
Qiuxia Yang, Yiqi Wang, Xiaohua Ban, Jing Wu, Dailin Rong, Qianqian Zhao, Chuanmiao Xie, Rong Zhang
PURPOSE: To investigate the predictive clinical and imaging factors associated with pulmonary metastasis in pulmonary nodules (PNs) ≤10 mm in patients with primary extrapulmonary malignancy (PEPM) on initial CT as well as the inter-nodular imaging features in the non-solitary PNs patients, to make a more reliable diagnosis and appropriate management of the PNs at an earlier stage after detection. MATERIALS AND METHODS: 161 patients with PNs ≤10 mm were reviewed from April 2013 to December 2013...
July 18, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28721407/3d-printed-reversible-shape-changing-soft-actuators-assisted-by-liquid-crystal-elastomers
#18
Chao Yuan, Devin J Roach, Conner K Dunn, Quanyi Mu, Xiao Kuang, Christopher M Yakacki, T J Wang, Kai Yu, H Jerry Qi
In this work, we advance printed active composites by combining 3D printing, printed electronics, and liquid crystal elastomers (LCEs) to achieve soft actuators with free-standing two-way shape changing behaviors. Incorporated LCE strips are activated by Joule heating produced by printed conductive wires, while uniaxial deformation of the LCE strip is utilized as a driving force to achieve bending in the printed composite. The bending behavior of laminated hinges is first characterized in order to obtain a precise control of actuation, which is then exploited to actuate four demonstrative designs: a morphing airplane, a miura-ori structure, a cubic box, and a soft crawler...
July 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28721282/structural-differences-and-architectural-features-of-two-different-polypropylene-slings-tvt-o-and-i-stop-have-no-impact-on-biocompatibility-and-tissue-reactions
#19
Mikolaj Przydacz, Oussama El Yazami Adli, Wally Mahfouz, Oleg Loutochin, Louis R Bégin, Jacques Corcos
INTRODUCTION: To evaluate the impact of design features of the synthetic mid-urethral slings on tissue integrity and inflammatory responses. MATERIAL AND METHODS: In total 30 female Sprague-Dawley rats were implanted with type I monofilamentous, macroporous polypropylene meshes: Gynecare TVT-Obturator tape(®) (Ethicon Inc., Johnson & Johnson, Somerville, NJ, USA) and I-STOP(®) (CL Medical Inc., Lyon, France). All animal groups were sacrificed at set time intervals - 6 weeks, 3 months, 6 months, 9 months and 12 months - and the abdominal wall was harvested with mesh strips for histological evaluation...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28720761/parylene-c-topographic-micropattern-as-a-template-for-patterning-pdms-and-polyacrylamide-hydrogel
#20
Ilaria Sanzari, Mauro Callisti, Antonio De Grazia, Daniel J Evans, Tomas Polcar, Themistoklis Prodromakis
Parylene C is a well-known polymer and it has been mainly employed as a protective layer for implantable electronics. In this paper, we propose a new approach to use Parylene C as a versatile template for patterning soft materials potentially applicable as scaffolds in cardiac tissue engineering (TE). Parylene C substrates were anisotropically patterned through standard lithographic process with hydrophilic channels separating raised hydrophobic strips. Ridges and grooves of the template are 10 µm width and depth ranging from 1 to 17 µm...
July 18, 2017: Scientific Reports
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