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https://www.readbyqxmd.com/read/29235616/-social-cognition-in-parkinson-s-disease-dementia-and-behavioral-variant-of-frontotemporal-dementia
#1
M E Tabernero, F Musich, F C Cossini, D G Politis
AIM: To study the presence of alterations in social cognition in Parkinson's disease dementia (PDD) and behavioral variant frontotemporal dementia (bvFTD), to compare the levels of involvement, and to analyze their relevance as a tool to distinguish between both demential profile. SUBJECTS AND METHODS: For this purpose, 34 patients diagnosed with PDD, 21 men and 13 women, with an average age of 70 years and 8 years of education, and 26 patients diagnosed with bvFTD, 9 men and 17 women, with an average age of 68 years and 6 years of education, were assessed...
December 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29209876/mentalization-deficit-in-bipolar-patients-during-an-acute-depressive-and-manic-episode-association-with-cognitive-functions
#2
Anna Bodnar, Janusz K Rybakowski
BACKGROUND: A number of studies in bipolar patients have shown a deficit in mentalization (theory of mind), one of the main aspects of social cognition. The aim of current study was to assess both cognitive and affective mentalization in well-defined groups of depressed and manic bipolar patients, compared to healthy control subjects, using a battery of tests measuring mentalization processes. The second aim was to investigate a possible relationship between cognitive and affective mentalization and cognitive functions in bipolar patients during a depressive and manic episode...
December 6, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29156426/theory-of-mind-and-schizophrenia-in-young-and-middle-aged-patients-influence-of-executive-functions
#3
Marta Croca, Aurèlie Lagodka, Remi Gadel, Marie Chantal Bourdel, Narjes Bendjemaa, Raphael Gaillard, Jean Pierre Olié, M Champagne-Lavau, Marie Odile Krebs, Isabelle Amado
Theory of Mind (ToM) is compromised in schizophrenia, and responsible for social disability. We aim to study the correlation between ToM deficits and Executive Functions (EF), using the Faux Pas Test (FPT) for ToM evaluation, Behavioral Assessment of the Dysexecutive Syndrome (BADS) and Wisconsin Card Sorting Test (WCST) for EF assessment. Two groups of patients with schizophrenia were included: 22 young (18-35 years-old) and 18 middle-aged (>50 years-old) Patients, compared to age-matched Controls. We found worst FPT performances in both groups of patients, but with a more generalized pattern of dysfunction in the middle-aged patient group...
November 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29136634/treatment-and-outcomes-of-working-aged-adults-with-stroke-results-from-a-national-prospective-registry
#4
Natasha A Lannin, Craig S Anderson, Joosup Kim, Monique Kilkenny, Julie Bernhardt, Christopher Levi, Helen M Dewey, Christopher Bladin, Peter Hand, Helen Castley, Kelvin Hill, Steven Faux, Rohan Grimley, Brenda Grabsch, Sandy Middleton, Geoffrey Donnan, Dominique A Cadilhac
BACKGROUND: Given the potential differences in etiology and impact, the treatment and outcome of younger patients (aged 18-64 years) require examination separately to older adults (aged ≥65 years) who experience acute stroke. METHODS: Data from the Australian Stroke Clinical Registry (2010-2015) including demographic and clinical characteristics, provision of evidence-based therapies and health-related quality of life (HRQoL) post-stroke was used. Descriptive statistics and multilevel regression models were used for group comparisons...
November 14, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29079657/torc1-and-torc2-converge-to-regulate-the-saga-co-activator-in-response-to-nutrient-availability
#5
Thomas Laboucarié, Dylane Detilleux, Ricard A Rodriguez-Mias, Céline Faux, Yves Romeo, Mirita Franz-Wachtel, Karsten Krug, Boris Maček, Judit Villén, Janni Petersen, Dominique Helmlinger
Gene expression regulation is essential for cells to adapt to changes in their environment. Co-activator complexes have well-established roles in transcriptional regulation, but less is known about how they sense and respond to signaling cues. We have previously shown that, in fission yeast, one such co-activator, the SAGA complex, controls gene expression and the switch from proliferation to differentiation in response to nutrient availability. Here, using a combination of genetic, biochemical, and proteomic approaches, we show that SAGA responds to nutrients through the differential phosphorylation of its Taf12 component, downstream of both the TORC1 and TORC2 pathways...
October 27, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28953779/comparative-analysis-of-theory-of-mind-tests-in-first-episode-psychosis-patients
#6
Alexandra Morozova, Zhanna Garakh, Marie Bendova, Yuliya Zaytseva
The research is based on comparative analysis of 'Hinting Task', 'Faux Pas', and 'Reading the Mind in the Eyes' tests sensitivity in detection of Theory of Mind deficits. The study included 20 subjects with schizophrenia and schizophrenia spectrum disorders with the first episode of psychosis. Every subject performed the three proposed tests. It was shown that success rate of the three tests differed significantly. The non-verbal test 'Reading the Mind in the Eyes' caused the most difficulties. The success rate percentage of this test performance correlated negatively with the severity of psychopathological symptoms evaluated according to the PANSS scale...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28920569/high-functioning-autism-patients-share-similar-but-more-severe-impairments-in-verbal-theory-of-mind-than-schizophrenia-patients
#7
L N W Tin, S S Y Lui, K K Y Ho, K S Y Hung, Y Wang, H K H Yeung, T Y Wong, S M Lam, R C K Chan, E F C Cheung
BACKGROUND: Evidence suggests that autism and schizophrenia share similarities in genetic, neuropsychological and behavioural aspects. Although both disorders are associated with theory of mind (ToM) impairments, a few studies have directly compared ToM between autism patients and schizophrenia patients. This study aimed to investigate to what extent high-functioning autism patients and schizophrenia patients share and differ in ToM performance. METHODS: Thirty high-functioning autism patients, 30 schizophrenia patients and 30 healthy individuals were recruited...
September 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28885057/plasticity-in-older-adults-theory-of-mind-performance-the-impact-of-motivation
#8
Xin Zhang, Serena Lecce, Irene Ceccato, Elena Cavallini, Linfang Zhang, Tianyong Chen
OBJECTIVE: Recently, motivation has been found to attenuate the age-related decline in Theory of Mind (ToM) performance (i.e. faux pas recognition). However, whether or not this effect could be generalized to other ToM tasks is still unknown. In the present study, we investigated whether and how motivation could enhance older adults' performance and reduce age differences in ToM tasks (Faux Pas vs. Animation task) that differ in familiarity. METHOD: Following a previous paradigm, 171 Chinese adults (87 younger adults and 84 older adults) were recruited, and we experimentally manipulated the level of perceived closeness between participants and the experimenter before administering the ToM tasks in order to enhance participants' motivation...
September 8, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28841511/psychometric-properties-of-three-measures-assessing-advanced-theory-of-mind-evidence-from-people-with-schizophrenia
#9
Kuan-Wei Chen, Shih-Chieh Lee, Hsin-Yu Chiang, Ya-Cing Syu, Xiao-Xuan Yu, Ching-Lin Hsieh
Patients with schizophrenia tend to have deficits in advanced Theory of Mind (ToM). The "Reading the mind in the eyes" test (RMET), the Faux Pas Task, and the Strange Stories are commonly used for assessing advanced ToM. However, most of the psychometric properties of these 3 measures in patients with schizophrenia are unknown. The aims of this study were to validate the psychometric properties of the 3 advanced ToM measures in patients with schizophrenia, including: (1) test-retest reliability; (2) random measurement error; (3) practice effect; (4) concurrent validity; and (5) ecological validity...
August 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28795598/inhibition-studies-of-dna-methyltransferases-by-maleimide-derivatives-of-rg108-as-non-nucleoside-inhibitors
#10
Grégoire Rondelet, Laurence Fleury, Céline Faux, Véronique Masson, Jean Dubois, Paola B Arimondo, Luc Willems, Johan Wouters
AIM: DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs. However, these compounds still have low activity in cancer cells and mode of action of these compounds remains unclear. MATERIALS & METHODS: In this work, we studied maleimide derivatives of RG108 by biochemical, structural and computational approaches to highlight their inhibition mechanism on DNMTs...
September 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28755605/affective-and-cognitive-theory-of-mind-in-borderline-personality-disorder-the-role-of-comorbid-depression
#11
Abbas Zabihzadeh, Gheysar Maleki, Mara J Richman, AmirJalal Hatami, Zahedeh Alimardani, Mostafa Heidari
Disturbed interpersonal relationships and misreading of others' intentions are core symptoms of borderline personality disorder (BPD). Despite these impairments, some studies have found an enhanced theory of mind (ToM) in BPD patients. Taking this into consideration, the current study attempts to further understand these discrepancies by separating ToM into two domains: affective and cognitive. Moreover, the study considered the role of comorbid symptoms of depression in these patients. Subjects were 21 patients with BPD, 23 patients with BPD and comorbid major depressive disorder (MDD), and 25 healthy controls (HC)...
July 19, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28704375/the-effect-of-the-promiscuity-stereotype-on-opposition-to-gay-rights
#12
David Pinsof, Martie G Haselton
Opposition to gay rights is prevalent in countries around the world. Recent correlational research suggests that opposition to gay rights may be driven by an interaction between one's own short-term mating orientation (i.e. willingness to engage in casual sex) and representations of gay people as sexually promiscuous. Here, we experimentally manipulated representations of gay men by randomly assigning participants to read one of two versions of a fictitious newspaper article, one of which contained faux scientific evidence confirming the stereotype that gay men are promiscuous, and the other containing faux scientific evidence refuting the stereotype...
2017: PloS One
https://www.readbyqxmd.com/read/28683114/evidence-for-arrogance-on-the-relative-importance-of-expertise-outcome-and-manner
#13
Maxim Milyavsky, Arie W Kruglanski, Marina Chernikova, Noa Schori-Eyal
Arrogant behavior is as old as human nature. Nonetheless, the factors that cause people to be perceived as arrogant have received very little research attention. In this paper, we focused on a typical manifestation of arrogance: dismissive behavior. In particular, we explored the conditions under which a person who dismissed advice would be perceived as arrogant. We examined two factors: the advisee's competence, and the manner in which he or she dismissed the advice. The effect of the advisee's competence was tested by manipulating two competence cues: relative expertise, and the outcome of the advice dismissal (i...
2017: PloS One
https://www.readbyqxmd.com/read/28679696/distinct-developmental-pathways-underlie-independent-losses-of-flight-in-ratites
#14
Cynthia Faux, Daniel J Field
Recent phylogenetic studies question the monophyly of ratites (large, flightless birds incorporating ostriches, rheas, kiwis, emus and cassowaries), suggesting their paraphyly with respect to flying tinamous (Tinamidae). Flightlessness and large body size have thus likely evolved repeatedly among ratites, and separately in ostriches (Struthio) and emus (Dromaius). Here, we test this hypothesis with data from wing developmental trajectories in ostriches, emus, tinamous and chickens. We find the rate of ostrich embryonic wing growth falls within the range of variation exhibited by flying taxa (tinamous and chickens), but that of emus is extremely slow...
July 2017: Biology Letters
https://www.readbyqxmd.com/read/28584926/theory-of-mind-performance-in-parkinson-s-disease-is-associated-with-motor-and-cognitive-functions-but-not-with-symptom-lateralization
#15
Lisa Nobis, Katharina Schindlbeck, Felicitas Ehlen, Hannes Tiedt, Charlotte Rewitzer, Annelien A Duits, Fabian Klostermann
Next to the typical motor signs, Parkinson's disease (PD) goes along with neuropsychiatric symptoms, amongst others affecting social cognition. Particularly, Theory of Mind (ToM) impairments have mostly been associated with right hemispherical brain dysfunction, so that it might prevail in patients with left dominant PD. Fourty-four PD patients, twenty-four with left and twenty with right dominant motor symptoms, engaged in the Reading the Mind in the Eyes (RME) and the Faux Pas Detection Test (FPD) to assess affective and cognitive ToM...
June 5, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28558473/theory-of-mind-and-empathy-in-children-with-adhd
#16
Hagai Maoz, Hila Z Gvirts, Maya Sheffer, Yuval Bloch
OBJECTIVE: The current study compared empathy and theory of mind (ToM) between children with ADHD and healthy controls, and assessed changes in ToM among children with ADHD following administration of methylphenidate (MPH). METHOD: Twenty-four children with ADHD (mean age = 10.3 years) were compared with 36 healthy controls. All children completed the interpersonal reactivity index (IRI), a self-reported empathy questionnaire, and performed the "faux-pas" recognition task (FPR)...
May 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28542205/rots-an-r-package-for-reproducibility-optimized-statistical-testing
#17
Tomi Suomi, Fatemeh Seyednasrollah, Maria K Jaakkola, Thomas Faux, Laura L Elo
Differential expression analysis is one of the most common types of analyses performed on various biological data (e.g. RNA-seq or mass spectrometry proteomics). It is the process that detects features, such as genes or proteins, showing statistically significant differences between the sample groups under comparison. A major challenge in the analysis is the choice of an appropriate test statistic, as different statistics have been shown to perform well in different datasets. To this end, the reproducibility-optimized test statistic (ROTS) adjusts a modified t-statistic according to the inherent properties of the data and provides a ranking of the features based on their statistical evidence for differential expression between two groups...
May 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28511677/a-strategy-to-improve-phasing-of-whole-genome-sequenced-individuals-through-integration-of-familial-information-from-dense-genotype-panels
#18
Pierre Faux, Tom Druet
BACKGROUND: Haplotype reconstruction (phasing) is an essential step in many applications, including imputation and genomic selection. The best phasing methods rely on both familial and linkage disequilibrium (LD) information. With whole-genome sequence (WGS) data, relatively small samples of reference individuals are generally sequenced due to prohibitive sequencing costs, thus only a limited amount of familial information is available. However, reference individuals have many relatives that have been genotyped (at lower density)...
May 16, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28487163/a-multi-year-study-of-hepatic-biomarkers-in-coastal-fishes-from-the-gulf-of-mexico-after-the-deepwater-horizon-oil-spill
#19
Marci Smeltz, Laura Rowland-Faux, Céline Ghiran, William F Patterson, Steven B Garner, Alan Beers, Quentin Mièvre, Andrew S Kane, Margaret O James
Following the 2010 Gulf of Mexico oil spill, concerns were raised regarding exposure of fish to crude oil components, particularly polycyclic aromatic hydrocarbons (PAHs). This three year study examined hepatic enzymes in post-mitochondrial supernatant fractions from red snapper (Lutjanus campechanus) and gray triggerfish (Balistes capriscus) collected in the north central Gulf of Mexico between 2011 and 2014. Biomarker activities evaluated included benzo(a)pyrene hydroxylase (AHH), ethoxyresorufin O-deethylase (EROD), glutathione transferase (GST), and glutathione peroxidase (GPx)...
August 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28474126/sex-differences-in-amino-acids-lost-via-sweating-could-lead-to-differential-susceptibilities-to-disturbances-in-nitrogen-balance-and-collagen-turnover
#20
R H Dunstan, D L Sparkes, B J Dascombe, C J Stevens, G R Murphy, M M Macdonald, J Gottfries, C-G Gottfries, T K Roberts
Fluid collected during sweating is enriched with amino acids derived from the skin's natural moisturising factors and has been termed "faux" sweat. Little is known about sex differences in sweat amino acid composition or whether faux sweat amino acid losses affect nitrogen balance. Faux sweat collected by healthy adults (n = 47) after exercise, and at rest by chronic fatigue patients, was analysed for amino acid composition. Healthy females had higher total amino acid concentrations in sweat (10.5 ± 1...
August 2017: Amino Acids
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