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https://www.readbyqxmd.com/read/28104669/sex-specific-outcomes-with-addition-of-defibrillation-to-resynchronisation-therapy-in-patients-with-heart-failure
#1
Sérgio Barra, Rui Providência, Rudolf Duehmke, Serge Boveda, Eloi Marijon, Christian Reitan, Rasmus Borgquist, Didier Klug, Pascal Defaye, Nicolas Sadoul, Jean-Claude Deharo, Iannish Sadien, Kiran Patel, Khang-Li Looi, David Begley, Anthony W Chow, Jean-Yves Le Heuzey, Sharad Agarwal
OBJECTIVE: Among primary prevention patients with heart failure receiving cardiac resynchronisation therapy (CRT), the impact of additional implantable cardioverter defibrillator (ICD) treatment on outcomes and its interaction with sex remains uncertain. We aim to assess whether the addition of the ICD functionality to CRT devices offers a more pronounced survival benefit in men compared with women, as previous research has suggested. METHODS: Observational multicentre cohort study of 5307 consecutive patients with ischaemic or non-ischaemic dilated cardiomyopathy and no history of sustained ventricular arrhythmias having CRT implantation with (cardiac resynchronisation therapy defibrillator (CRT-D), n=4037) or without (cardiac resynchronisation therapy pacemaker (CRT-P), n=1270) defibrillator functionality...
January 19, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28092359/lysine-relay-mechanism-coordinates-intermediate-transfer-in-vitamin-b6-biosynthesis
#2
Matthew J Rodrigues, Volker Windeisen, Yang Zhang, Gabriela Guédez, Stefan Weber, Marco Strohmeier, Jeremiah W Hanes, Antoine Royant, Gwyndaf Evans, Irmgard Sinning, Steven E Ealick, Tadhg P Begley, Ivo Tews
Substrate channeling has emerged as a common mechanism for enzymatic intermediate transfer. A conspicuous gap in knowledge concerns the use of covalent lysine imines in the transfer of carbonyl-group-containing intermediates, despite their wideuse in enzymatic catalysis. Here we show how imine chemistry operates in the transfer of covalent intermediates in pyridoxal 5'-phosphate biosynthesis by the Arabidopsis thaliana enzyme Pdx1. An initial ribose 5-phosphate lysine imine is converted to the chromophoric I320 intermediate, simultaneously bound to two lysine residues and partially vacating the active site, which creates space for glyceraldehyde 3-phosphate to bind...
January 16, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28068948/women-s-preferences-for-childbirth-experiences-in-the-republic-of-ireland-a-mixed-methods-study
#3
Patricia Larkin, Cecily M Begley, Declan Devane
BACKGROUND: How women experience childbirth is acknowledged as critical to the postnatal wellbeing of mother and baby. However there is a knowledge deficit in identifying the important elements of these experiences in order to enhance care. This study elicits women's preferences for the most important elements of their childbirth experiences. METHODS: A mixed methods design was used. An initial qualitative phase (reported previously) was followed by a second quantitative one using a discrete choice experiment (DCE), which is reported on here...
January 10, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28040895/biosynthesis-of-branched-alkoxy-groups-iterative-methyl-group-alkylation-by-a-cobalamin-dependent-radical-sam-enzyme
#4
Yuanyou Wang, Bastien Schnell, Sascha Baumann, Rolf Müller, Tadhg P Begley
The biosynthesis of branched alkoxy groups like the unique t-butyl group found in a variety of natural products, is still poorly understood. Recently, cystobactamids were isolated and identified from Cystobacter sp as novel antibacterials. These metabolites contain an isopropyl group proposed to be formed using CysS, a cobalamin-dependent radical S-adenosylmethionine (SAM) methyltransferase. Here, we reconstitute the CysS-catalyzed reaction and demonstrate that it not only performs sequential methylations of a methyl group to form isopropyl groups but remarkably also t-butyl groups on p-aminobenzoate thioester substrates...
December 31, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28031276/patients-upgraded-to-cardiac-resynchronization-therapy-due-to-pacing-induced-cardiomyopathy-are-at-low-risk-of-life-threatening-ventricular-arrhythmias-a-long-term-cause-of-death-analysis
#5
Sergio Barra, Rudolf Duehmke, Rui Providencia, Eloi Marijon, Serge Boveda, Munmohan Virdee, Patrick Heck, Simon Fynn, David Begley, Andrew Grace, Sharad Agarwal
AIMS: Upgrade to cardiac resynchronization therapy (CRT) should be offered to patients who have developed pacing-induced cardiomyopathy with conventional right ventricular pacing. The extent to which these patients would also benefit from defibrillator back-up at the time of CRT upgrade is, however, unknown. METHODS AND RESULTS: Retrospective observational cohort study of 199 patients with pacing-induced cardiomyopathy and no history of sustained ventricular arrhythmia, including 104 upgraded to CRT-Pacemaker (CRT-P) and 95 upgraded to CRT-Defibrillator (CRT-D)...
December 28, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27998091/tryptophan-lyase-nosl-a-cornucopia-of-5-deoxyadenosyl-radical-mediated-transformations
#6
Dhananjay M Bhandari, Dmytro Fedoseyenko, Tadhg P Begley
Tryptophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the formation of 3-methyl-2-indolic acid from l-tryptophan. In this paper, we demonstrate that the 5'-deoxyadenosyl radical is considerably more versatile in its chemistry than previously anticipated: hydrogen atom abstraction from Nα-cyclopropyltryptophan occurs at Cα rather than the amino group with NosL Y90A and replacing the substrate amine with a ketone or an alkene changes the chemistry from hydrogen atom abstraction to double bond addition...
December 21, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27983809/a-collaborative-study-determination-of-mycotoxins-in-corn-peanut-butter-and-wheat-flour-using-stable-isotope-dilution-assay-sida-and-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#7
Kai Zhang, Matthew R Schaab, Gavin Southwood, Elizabeth R Tor, Linda S Aston, Wenlu Song, Brian Eitzer, Sanghamitra Majumdar, Theodore Lapainis, Huy Mai, Kevin Tran, Aref El-Demerdash, Victor Vega, Yanxuan Cai, Jon W Wong, Alexandra J Krynitsky, Timothy H Begley
A collaborative study was conducted to evaluate stable isotope dilution assay (SIDA) and LC-MS/MS for the simultaneous determination of aflatoxins B1, B2, G1, and G2; deoxynivalenol; fumonisins B1, B2, and B3; ochratoxin A; HT-2 toxin; T-2 toxin; and zearalenone in foods. Samples were fortified with 12 (13)C uniformly labeled mycotoxins ((13)C-IS) corresponding to the native mycotoxins and extracted with acetonitrile/water (50:50 v/v), followed by centrifugation, filtration, and LC-MS/MS analysis. In addition to certified reference materials, the six participating laboratories analyzed corn, peanut butter, and wheat flour fortified with the 12 mycotoxins at concentrations ranging from 1...
January 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27931191/experiences-of-health-care-in-women-with-peripartum-cardiomyopathy-in-sweden-a-qualitative-interview-study
#8
Harshida Patel, Maria Schaufelberger, Cecily Begley, Marie Berg
BACKGROUND: Peripartum cardiomyopathy is often associated with severe heart failure occurring towards the end of pregnancy or in the months following birth with debilitating, exhausting and frightening symptoms requiring person-centered care. The aim of this study was to explore women's experiences of health care while being diagnosed with peripartum cardiomyopathy. METHOD: Qualitative interviews were conducted with 19 women with peripartum cardiomyopathy in Sweden, following consent...
December 8, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27834374/trna-mediated-codon-biased-translation-in-mycobacterial-hypoxic-persistence
#9
Yok Hian Chionh, Megan McBee, I Ramesh Babu, Fabian Hia, Wenwei Lin, Wei Zhao, Jianshu Cao, Agnieszka Dziergowska, Andrzej Malkiewicz, Thomas J Begley, Sylvie Alonso, Peter C Dedon
Microbial pathogens adapt to the stress of infection by regulating transcription, translation and protein modification. We report that changes in gene expression in hypoxia-induced non-replicating persistence in mycobacteria-which models tuberculous granulomas-are partly determined by a mechanism of tRNA reprogramming and codon-biased translation. Mycobacterium bovis BCG responded to each stage of hypoxia and aerobic resuscitation by uniquely reprogramming 40 modified ribonucleosides in tRNA, which correlate with selective translation of mRNAs from families of codon-biased persistence genes...
November 11, 2016: Nature Communications
https://www.readbyqxmd.com/read/27832743/clinicians-views-of-factors-of-importance-for-improving-the-rate-of-vbac-vaginal-birth-after-caesarean-section-a-study-from-countries-with-low-vbac-rates
#10
Ingela Lundgren, Patricia Healy, Margaret Carroll, Cecily Begley, Andrea Matterne, Mechthild M Gross, Susanne Grylka-Baeschlin, Jane Nicoletti, Sandra Morano, Christina Nilsson, Joan Lalor
BACKGROUND: Caesarean section (CS) rates are increasing worldwide and the most common reason is repeat CS following previous CS. For most women a vaginal birth after a previous CS (VBAC) is a safe option. However, the rate of VBAC differs in an international perspective. Obtaining deeper knowledge of clinicians' views on VBAC can help in understanding the factors of importance for increasing VBAC rates. Focus group interviews with clinicians and women in three countries with high VBAC rates (Finland, Sweden and the Netherlands) and three countries with low VBAC rates (Ireland, Italy and Germany) are part of "OptiBIRTH", an ongoing research project...
November 10, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27811904/omfs-do-your-research
#11
A Begley, P Magennis
No abstract text is available yet for this article.
November 4, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27793111/bipolar-disorder-in-pregnancy-and-childbirth-a-systematic-review-of-outcomes
#12
Marie Rusner, Marie Berg, Cecily Begley
BACKGROUND: Bipolar Disorder (BD) is a mental disorder usually diagnosed between 18 and 30 years of age; this coincides with the period when many women experience pregnancy and childbirth. As specific problems have been reported in pregnancy and childbirth when the mother has BD, a systematic review was carried out to summarise the outcomes of pregnancy and childbirth, in mother and child, when the mother has BD diagnosed before pregnancy. METHODS: An a priori protocol was designed and a systematic search conducted in PubMed, CINAHL, Scopus, PsycINFO and Cochrane databases in March 2015...
October 28, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27642181/early-maladaptive-schemas-in-adult-survivors-of-interpersonal-trauma-foundations-for-a-cognitive-theory-of-psychopathology
#13
Thanos Karatzias, Sally Jowett, Amelie Begley, Suzanne Deas
BACKGROUND: Although the association between psychological trauma and early maladaptive schemas (EMS) is well established in the literature, no study to date has examined the relationship of EMS to PTSD and psychopathologies beyond depression and anxiety in a sample of adult survivors of interpersonal trauma. This information may be useful in helping our understanding on how to best treat interpersonal trauma. OBJECTIVE: We set out to investigate the association between EMS and common forms of psychopathology in a sample of women with a history of interpersonal trauma (n=82)...
2016: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/27631712/collaborative-learning-in-the-texas-medicaid-1115-waiver-program
#14
Lee Revere, Adele Semaan, Nicole Lievsay, Jessica Hall, Zheng M Wang, Charles Begley
The Texas Medicaid 1115 Transformation Waiver reforms the state's safety net systems by creating a Delivery System Reform Incentive Payment incentive pool for innovative healthcare delivery. The Waiver supports the design and implementation of transformative projects. As part of the Waiver requirements, regions created Learning Collaboratives to collaborate on project implementation and outcomes. This paper describes the experience of one region in adapting the Institute for Healthcare Improvement Breakthrough Series (IHI BTS) model, as a framework for their Learning Collaborative...
September 13, 2016: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/27605553/heat-shock-protein-based-therapy-as-a-potential-candidate-for-treating-the-sphingolipidoses
#15
Thomas Kirkegaard, James Gray, David A Priestman, Kerri-Lee Wallom, Jennifer Atkins, Ole Dines Olsen, Alexander Klein, Svetlana Drndarski, Nikolaj H T Petersen, Linda Ingemann, David A Smith, Lauren Morris, Claus Bornæs, Signe Humle Jørgensen, Ian Williams, Anders Hinsby, Christoph Arenz, David Begley, Marja Jäättelä, Frances M Platt
Lysosomal storage diseases (LSDs) often manifest with severe systemic and central nervous system (CNS) symptoms. The existing treatment options are limited and have no or only modest efficacy against neurological manifestations of disease. We demonstrate that recombinant human heat shock protein 70 (HSP70) improves the binding of several sphingolipid-degrading enzymes to their essential cofactor bis(monoacyl)glycerophosphate in vitro. HSP70 treatment reversed lysosomal pathology in primary fibroblasts from 14 patients with eight different LSDs...
September 7, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27596720/the-prevalence-of-women-s-emotional-and-physical-health-problems-following-a-postpartum-haemorrhage-a-systematic-review
#16
Margaret Carroll, Deirdre Daly, Cecily M Begley
BACKGROUND: Postpartum Haemorrhage (PPH) is a leading cause of maternal mortality with approximately 225 women dying as a result of it each day especially in low income countries. However, much less is known about morbidity after a PPH. This systematic review aimed to determine the overall prevalence of emotional and physical health problems experienced by women following a postpartum haemorrhage. METHODS: Eight databases were searched for published non-randomised, observational, including cohort, primary research studies that reported on the prevalence of emotional and/or physical health problems following a PPH...
September 5, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27590337/identification-of-the-first-riboflavin-catabolic-gene-cluster-isolated-from-microbacterium-maritypicum-g10
#17
Hui Xu, Yindrila Chakrabarty, Benjamin Philmus, Angad P Mehta, Dhananjay Bhandari, Hans-Peter Hohmann, Tadhg P Begley
Riboflavin is a common cofactor, and its biosynthetic pathway is well characterized. However, its catabolic pathway, despite intriguing hints in a few distinct organisms, has never been established. This article describes the isolation of a Microbacterium maritypicum riboflavin catabolic strain, and the cloning of the riboflavin catabolic genes. RcaA, RcaB, RcaD, and RcaE were overexpressed and biochemically characterized as riboflavin kinase, riboflavin reductase, ribokinase, and riboflavin hydrolase, respectively...
November 4, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27581914/the-extent-to-which-core-nursing-textbooks-inform-holistic-spiritual-care
#18
Fiona Timmins, Maryanne Murphy, Thelma Begley, Freda Neill, Greg Sheaf
National and international professional health and nursing guidelines recommend that attention should be given to the spiritual and religious needs of patients. This suggests that spiritual care is an important aspect of holistic patient care that needs to be considered and supported, if relevant, in a healthcare context. However, many nurses lack knowledge and awareness of the subject, and it is unclear to what extent core textbooks provide the information they need. This article reports on a study that explored the extent to which contemporary core nursing textbooks support and advocate the provision of spiritual care by nurses...
September 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27561672/workforce-capacity-to-address-obesity-a-western-australian-cross-sectional-study-identifies-the-gap-between-health-priority-and-human-resources-needed
#19
Andrea Begley, Christina Mary Pollard
BACKGROUND: The disease burden due to poor nutrition, physical inactivity and obesity is high and increasing. An adequately sized and skilled workforce is required to respond to this issue. This study describes the public health nutrition and physical activity (NAPA) practice priorities and explores health managers and practitioner's beliefs regarding workforce capacity to deliver on these priorities. METHODS: A workforce audit was conducted including a telephone survey of all managers and a postal survey of practitioners working in the area of NAPA promotion in Western Australia in 2004...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27560033/characterizing-contact-lens-related-corneal-infiltrates-a-pilot-study
#20
Meredith E Jansen, Ping Situ, Carolyn G Begley, Danielle Boree, Robin L Chalmers, Kathrine Osborn Lorenz, Tawnya Wilson
PURPOSE: To document the time course and resolution of contact lens-related corneal infiltrative events (CIEs) comparing slit-lamp images with anterior segment ocular coherence tomography (AS-OCT) images. METHODS: Six silicone hydrogel (SiHy) soft contact lens (SCL) wearers presenting with newly diagnosed symptomatic CIEs were monitored with slit-lamp images, detailed drawings, and AS-OCT until the resolution of the CIE. A final follow-up visit was completed 4 weeks after CIE resolution to determine whether scar formation was present...
August 24, 2016: Cornea
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