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https://www.readbyqxmd.com/read/29746837/an-immunocompetent-mouse-model-of-zika-virus-infection
#1
Matthew J Gorman, Elizabeth A Caine, Konstantin Zaitsev, Matthew C Begley, James Weger-Lucarelli, Melissa B Uccellini, Shashank Tripathi, Juliet Morrison, Boyd L Yount, Kenneth H Dinnon, Claudia Rückert, Michael C Young, Zhe Zhu, Shelly J Robertson, Kristin L McNally, Jing Ye, Bin Cao, Indira U Mysorekar, Gregory D Ebel, Ralph S Baric, Sonja M Best, Maxim N Artyomov, Adolfo Garcia-Sastre, Michael S Diamond
Progress toward understanding Zika virus (ZIKV) pathogenesis is hindered by lack of immunocompetent small animal models, in part because ZIKV fails to effectively antagonize Stat2-dependent interferon (IFN) responses in mice. To address this limitation, we first passaged an African ZIKV strain (ZIKV-Dak-41525) through Rag1-/- mice to obtain a mouse-adapted virus (ZIKV-Dak-MA) that was more virulent than ZIKV-Dak-41525 in mice treated with an anti-Ifnar1 antibody. A G18R substitution in NS4B was the genetic basis for the increased replication, and resulted in decreased IFN-β production, diminished IFN-stimulated gene expression, and the greater brain infection observed with ZIKV-Dak-MA...
May 9, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29730096/a-qualitative-exploration-of-techniques-used-by-expert-midwives-to-preserve-the-perineum-intact
#2
C Begley, K Guilliland, L Dixon, M Reilly, C Keegan, C McCann, V Smith
BACKGROUND: The perineum stretches during birth to allow passage of the baby, but 85% of women sustain some degree of perineal trauma during childbirth, which is painful post-partum. Episiotomy rates vary significantly, with some countries having rates of >60%. Recent Irish and New Zealand studies showed lower severe perineal trauma and episiotomy rates than other countries. AIM: To explore expert Irish and New Zealand midwives' views of the skills that they employ in preserving the perineum intact during spontaneous vaginal birth...
May 2, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29706340/predicting-the-combinatorial-effects-of-water-activity-ph-and-organic-acids-on-listeria-growth-in-media-and-complex-food-matrices
#3
L Nyhan, M Begley, A Mutel, Y Qu, N Johnson, M Callanan
The aim of this study was to develop a model to predict growth of Listeria in complex food matrices as a function of pH, water activity and undissociated acetic and propionic acid concentration i.e. common food hurdles. Experimental growth curves of Listeria in food products and broth media were collected from ComBase, the literature and industry sources from which a bespoke secondary gamma model was constructed. Model performance was evaluated by comparing predictions to measured growth rates in growth media (BHI broth) and two adjusted food matrices (zucchini purée and béarnaise sauce)...
September 2018: Food Microbiology
https://www.readbyqxmd.com/read/29653229/the-splicing-of-tiny-introns-of-paramecium-is-controlled-by-mago
#4
Julia Contreras, Victoria Begley, Laura Marsella, Eduardo Villalobo
The exon junction complex (EJC) is a key element of the splicing machinery. The EJC core is composed of eIF4A3, MAGO, Y14 and MLN51. Few accessory proteins, such as CWC22 or UPF3, bind transiently to the EJC. The EJC has been implicated in the control of the splicing of long introns. To ascertain whether the EJC controls the splicing of short introns, we used Paramecium tetraurelia as a model organism, since it has thousands of very tiny introns. To elucidate whether EJC affects intron splicing in P. tetraurelia, we searched for EJC protein-coding genes, and silenced those genes coding for eIF4A3, MAGO and CWC22...
April 10, 2018: Gene
https://www.readbyqxmd.com/read/29649076/pharmacokinetics-of-tenofovir-alafenamide-when-co-administered-with-other-hiv-antiretrovirals
#5
Rebecca Begley, Moupali Das, Lijie Zhong, John Ling, Brian P Kearney, Joseph M Custodio
BACKGROUND: Tenofovir alafenamide (TAF), a prodrug of the nucleotide analogue tenofovir (TFV), is an antiretroviral (ARV) agent approved either as a complete regimen (elvitegravir/cobicistat/emtricitabine (F)/tenofovir alafenamide (TAF), rilpivirine/F/TAF, bictegravir/F/TAF), or for use with other ARVs (F/TAF), for treatment of HIV. TAF is a substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) transporters. Disposition of TAF may be altered by co-medications that can inhibit or induce P-gp or BCRP transporters...
April 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29642858/vaginal-birth-after-caesarean-versus-elective-repeat-caesarean-delivery-after-one-previous-caesarean-section-a-cost-effectiveness-analysis-in-four-european-countries
#6
Maaike Fobelets, Katrien Beeckman, Gilles Faron, Déirdre Daly, Cecily Begley, Koen Putman
BACKGROUND: The OptiBIRTH study incorporates a multicentre cluster randomised trial in 15 hospital sites across three European countries. The trial was designed to test a complex intervention aimed at improving vaginal birth after caesarean section (VBAC) rates through increasing women's involvement in their care. Prior to developing a robust standardised model to conduct the health economic analysis, an analysis of a hypothetical cohort was performed to estimate the costs and health effects of VBAC compared to elective repeat caesarean delivery (ERCD) for low-risk women in four European countries...
April 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29615960/reported-changes-in-dietary-behavior-following-a-first-clinical-diagnosis-of-central-nervous-system-demyelination
#7
Rebecca D Russell, Robyn M Lucas, Vanessa Brennan, Jill L Sherriff, Andrea Begley, Lucinda J Black
Background/objectives: Although the current evidence is insufficient to recommend a special diet for people with multiple sclerosis (MS), dietary advice for people with MS is prolific online and in the media. This study aimed to describe dietary changes made in the year following a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS. Subjects/methods: We used follow-up data from the Ausimmune Study, a multicentre matched case-control study examining the environmental risk factors for a FCD...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29606512/continuous-and-minimally-interrupted-direct-oral-anticoagulant-are-both-safe-compared-with-vitamin-k-antagonist-for-atrial-fibrillation-ablation-an-updated-meta-analysis
#8
Francis J Ha, Sergio Barra, Adam J Brown, David B Begley, Andrew A Grace, Sharad Agarwal
BACKGROUND: The appropriate and safe peri-procedural anticoagulation schedule for patients on a direct oral anticoagulant (DOAC) undergoing AF ablation is not known. We aimed to evaluate the safety and efficacy of both continuous and minimally-interrupted novel oral anticoagulant (DOAC) strategies compared with uninterrupted vitamin K antagonist (VKA) for atrial fibrillation (AF) ablation. METHODS: We searched electronic databases for randomized or prospective controlled observational studies comparing DOAC (continuous or interrupted) versus uninterrupted VKA...
March 21, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29588451/identification-of-the-functional-pathways-altered-by-placental-cell-exposure-to-high-glucose-lessons-from-the-transcript-and-metabolite-interactome
#9
C H Hulme, A Stevens, W Dunn, A E P Heazell, K Hollywood, P Begley, M Westwood, J E Myers
The specific consequences of hyperglycaemia on placental metabolism and function are incompletely understood but likely contribute to poor pregnancy outcomes associated with diabetes mellitus (DM). This study aimed to identify the functional biochemical pathways perturbed by placental exposure to high glucose levels through integrative analysis of the trophoblast transcriptome and metabolome. The human trophoblast cell line, BeWo, was cultured in 5 or 25 mM glucose, as a model of the placenta in DM. Transcriptomic analysis using microarrays, demonstrated 5632 differentially expressed gene transcripts (≥± 1...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29562884/rationale-and-design-of-a-statewide-cohort-to-examine-efficient-resource-utilization-for-patients-with-intracerebral-hemorrhage-enrich
#10
Farhaan S Vahidy, Ellie G Meyer, Arvind B Bambhroliya, Jennifer R Meeks, Charles E Begley, Tzu-Ching Wu, Jon E Tyson, Charles C Miller, Ritvij Bowry, Wamda O Ahmed, Gretchel A Gealogo, Louise D McCullough, Steven Warach, Sean I Savitz
BACKGROUND: Intracerebral hemorrhage is a devastating disease with no specific treatment modalities. A significant proportion of patients with intracerebral hemorrhage are transferred to large stroke treatment centers, such as Comprehensive Stroke Centers, because of perceived need for higher level of care. However, evidence of improvement in patient-centered outcomes for these patients treated at larger stroke treatment centers as compared to community hospitals is lacking. METHODS / DESIGN: "Efficient Resource Utilization for Patients with Intracerebral Hemorrhage (EnRICH)" is a prospective, multisite, state-wide, cohort study designed to assess the impact of level of care on long-term patient-centered outcomes for patients with primary / non-traumatic intracerebral hemorrhage...
March 21, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29544346/how-are-people-with-dementia-involved-in-care-planning-and-decision-making-an-irish-social-work-perspective
#11
Sarah Donnelly, Emer Begley, Marita O'Brien
In recent years, there have been national and international policy advances around capacity and decision-making and an apparent burgeoning rights-based approach to the issue, all of which have the potential to impact on the experience for people with dementia in Ireland. There is little evidence however on whether these policies and principles are being translated into practice and whether traditional paternalistic approaches to decision-making are being challenged. To gain insight into current practice, research was undertaken with social workers working with older people in Ireland; reporting on the involvement of people living with dementia in care-planning processes...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29537904/the-development-of-an-instrument-to-evaluate-interprofessional-student-team-competency
#12
Lindsay Iverson, Martha Todd, Ann Ryan Haddad, Katie Packard, Kimberley Begley, Joy Doll, Kim Hawkins, Ann Laughlin, Julie Manz, Chris Wichman
Healthcare institutions, accreditation agencies for higher learning, and organizations such as the National Academy of Medicine in the United States, support interprofessional education (IPE) opportunities. However, incorporating IPE opportunities into academic settings remains difficult. One challenge is assessing IPE learning and practice outcomes, especially at the level of student performance to ensure graduates are "collaboration-ready". The Creighton-Interprofessional Collaborative Evaluation (C-ICE) instrument was developed to address the need for a measurement tool for interprofessional student team performance...
March 14, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29533925/circadian-clock-component-rev-erb%C3%AE-controls-homeostatic-regulation-of-pulmonary-inflammation
#13
Marie Pariollaud, Julie E Gibbs, Thomas W Hopwood, Sheila Brown, Nicola Begley, Ryan Vonslow, Toryn Poolman, Baoqiang Guo, Ben Saer, D Heulyn Jones, James P Tellam, Stefano Bresciani, Nicholas Co Tomkinson, Justyna Wojno-Picon, Anthony Wj Cooper, Dion A Daniels, Ryan P Trump, Daniel Grant, William Zuercher, Timothy M Willson, Andrew S MacDonald, Brian Bolognese, Patricia L Podolin, Yolanda Sanchez, Andrew Si Loudon, David W Ray
Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechanism coupling the pulmonary clock to innate immunity, involving both myeloid and bronchial epithelial cells in temporal gating and determining amplitude of response to inhaled endotoxin. Dual mutation of REV-ERBα and its paralog REV-ERBβ in bronchial epithelia further augmented inflammatory responses and chemokine activation, but also initiated a basal inflammatory state, revealing a critical homeostatic role for REV-ERB proteins in the suppression of the endogenous proinflammatory mechanism in unchallenged cells...
April 30, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29516299/plasma-metals-as-potential-biomarkers-in-dementia-a-case-control-study-in-patients-with-sporadic-alzheimer-s-disease
#14
Jingshu Xu, Stephanie J Church, Stefano Patassini, Paul Begley, Katherine A B Kellett, Emma R L C Vardy, Richard D Unwin, Nigel M Hooper, Garth J S Cooper
Sporadic Alzheimer's disease (AD) is a neurodegenerative disorder that causes the most prevalent form of age-related dementia but its pathogenesis remains obscure. Altered regulation of metals, particularly pan-cerebral copper deficiency, and more regionally-localized perturbation of other metals, are prominent in AD brain although data on how these CNS perturbations are reflected in the peripheral bloodstream are inconsistent to date. To assess the potential use of metal dysregulation to generate biomarkers in AD, we performed a case-control study of seven essential metals and selenium, measured by inductively coupled plasma mass-spectrometry, in samples from AD and matched control cases...
April 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29510083/investigation-of-the-primary-plasticisers-present-in-polyvinyl-chloride-pvc-products-currently-authorised-as-food-contact-materials
#15
Katherine S Carlos, Lowri S de Jager, Timothy H Begley
PVC is a common food contact material that is usually plasticised to increase its flexibility. Phthalates are one class of chemical compounds that are often used as plasticisers in PVC in a wide range of industries. They may be used in packaging materials for foods and can also be found in components of certain food processing equipment such as conveyor belts and tubing. Transfer of plasticisers from packaging to foods can occur. In recent years, there has been increased interest in understanding the health effects of phthalates, as well as the possible human exposure levels...
March 15, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29504297/demographic-and-clinical-correlates-of-seizure-frequency-findings-from-the-managing-epilepsy-well-network-database
#16
Erdong Chen, Martha Sajatovic, Hongyan Liu, Ashley Bukach, Curtis Tatsuoka, Elisabeth Welter, Samantha S Schmidt, Yvan A Bamps, Shelley C Stoll, Tanya M Spruill, Daniel Friedman, Charles E Begley, Ross Shegog, Robert T Fraser, Erica K Johnson, Barbara C Jobst
BACKGROUND AND PURPOSE: Epilepsy is a chronic neurological disease that represents a tremendous burden on both patients and society in general. Studies have addressed how demographic variables, socioeconomic variables, and psychological comorbidity are related to the quality of life (QOL) of people with epilepsy (PWE). However, there has been less focus on how these factors may differ between patients who exhibit varying degrees of seizure control. This study utilized data from the Managing Epilepsy Well (MEW) Network of the Centers for Disease Control and Prevention with the aim of elucidating differences in demographic variables, depression, and QOL between adult PWE...
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29502486/the-case-of-the-blue-gray-fingernails
#17
Hannah R Begley, Bruce H Gray
No abstract text is available yet for this article.
March 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29491349/the-circadian-regulator-bmal1-programmes-responses-to-parasitic-worm-infection-via-a-dendritic-cell-clock
#18
Thomas W Hopwood, Sarah Hall, Nicola Begley, Ruth Forman, Sheila Brown, Ryan Vonslow, Ben Saer, Matthew C Little, Emma A Murphy, Rebecca J Hurst, David W Ray, Andrew S MacDonald, Andy Brass, David A Bechtold, Julie E Gibbs, Andrew S Loudon, Kathryn J Else
Resistance to the intestinal parasitic helminth Trichuris muris requires T-helper 2 (TH 2) cellular and associated IgG1 responses, with expulsion typically taking up to 4 weeks in mice. Here, we show that the time-of-day of the initial infection affects efficiency of worm expulsion, with strong TH 2 bias and early expulsion in morning-infected mice. Conversely, mice infected at the start of the night show delayed resistance to infection, and this is associated with feeding-driven metabolic cues, such that feeding restriction to the day-time in normally nocturnal-feeding mice disrupts parasitic expulsion kinetics...
February 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29462166/oncologic-emergencies-in-a-cancer-center-emergency-department-and-in-general-emergency-departments-countywide-and-nationwide
#19
Zhi Yang, Runxiang Yang, Min Ji Kwak, Aiham Qdaisat, Junzhong Lin, Charles E Begley, Cielito C Reyes-Gibby, Sai-Ching Jim Yeung
BACKGROUND: Although cancer patients (CPs) are increasingly likely to visit emergency department (ED), no population-based study has compared the characteristics of CPs and non-cancer patients (NCPs) who visit the ED and examined factors associated with hospitalization via the ED. In this study, we (1) compared characteristics and diagnoses between CPs and NCPs who visited the ED in a cancer center or general hospital; (2) compared characteristics and diagnoses between CPs and NCPs who were hospitalized via the ED in a cancer center or general hospital; and (3) investigated important factors associated with such hospitalization...
2018: PloS One
https://www.readbyqxmd.com/read/29437130/case-3-progressive-leg-pain-and-weakness-in-a-16-year-old-boy
#20
Amanda Begley, Alicia Briggs, Christopher Williams
No abstract text is available yet for this article.
February 2018: Pediatrics in Review
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