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https://www.readbyqxmd.com/read/29133017/rpb5-modulates-the-rna-polymerase-ii-transition-from-initiation-to-elongation-by-influencing-spt5-association-and-backtracking
#1
Verónica Martínez-Fernández, Ana Isabel Garrido-Godino, María Carmen Mirón-García, Victoria Begley, Antonio Fernández-Pévida, Jesús de la Cruz, Sebastián Chávez, Francisco Navarro
Rpb5 is a subunit shared by the three eukaryotic RNA polymerases although its role in transcription remains unclear. It has been proposed that it makes contact with the promoter DNA and to participate in the co-ordination of the opening/closing of the RNA polymerase II DNA cleft. Here, we report the specific role of Rpb5 in the function of the yeast RNA polymerase II. The rpb5-P151T mutation specifically impairs transcription elongation by RNA polymerase II but does not influence the functions of RNA polymerases I or III...
November 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29117133/development-and-relative-validity-of-a-food-frequency-questionnaire-to-assess-intakes-of-total-and-free-sugars-in-australian-toddlers
#2
Gemma Devenish, Aqif Mukhtar, Andrea Begley, Loc Do, Jane Scott
Background: Dental research into early childhood caries is hindered by a lack of suitable dietary assessment tools that have been developed and validated for the population and outcomes of interest. The aim of this study was to develop and investigate the relative validity and reproducibility of the Study of Mothers' and Infants' Life Events Food Frequency Questionnaire (SMILE-FFQ), to assess the total and free sugars intakes of Australian toddlers. Methods: The SMILE-FFQ was designed to capture the leading dietary contributors to dental caries risk in toddlers aged 18-30 months via a proxy report...
November 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29107624/a-simple-and-cost-effective-method-for-preparing-fl-and-lg-solutions
#3
REVIEW
Deborah Awisi Gyau, Carolyn Begley, J Daniel Nelson
PURPOSE: The purpose of this study was to develop a clinically feasible method for obtaining dye concentrations of 2% fluorescein (FL) and 1% lissamine green (LG) by soaking commercially available dye impregnated strips in saline. METHODS: Calibration curves were established to related known concentrations of dye to prepared FL fluorescence and LG absorbance. To determine the optimum number of dye strips and soaking times (preliminary testing), 1, 2, 3 FL or LG strips were soaked in 200 μl commercially available saline for 0...
October 28, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29096544/a-systematic-review-investigating-the-behaviour-change-strategies-in-interventions-to-prevent-misuse-of-anabolic-steroids
#4
Geoff Bates, Emma Begley, David Tod, Lisa Jones, Conan Leavey, Jim McVeigh
We examined intervention effectiveness of strategies to prevent image- and performance-enhancing drug use. Comprehensive searches identified 14 interventions that met review inclusion criteria. Interventions were predominantly educational and delivered within school sport settings, but targeted a wide range of mediating factors. Identification of effective components was limited across studies by brief or imprecise descriptions of intervention content, lack of behavioural outcome measures and short-term follow-up times...
October 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/29092943/the-mouse-tumor-biology-database-a-comprehensive-resource-for-mouse-models-of-human-cancer
#5
Debra M Krupke, Dale A Begley, John P Sundberg, Joel E Richardson, Steven B Neuhauser, Carol J Bult
Research using laboratory mice has led to fundamental insights into the molecular genetic processes that govern cancer initiation, progression, and treatment response. Although thousands of scientific articles have been published about mouse models of human cancer, collating information and data for a specific model is hampered by the fact that many authors do not adhere to existing annotation standards when describing models. The interpretation of experimental results in mouse models can also be confounded when researchers do not factor in the effect of genetic background on tumor biology...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29092942/pdx-mi-minimal-information-for-patient-derived-tumor-xenograft-models
#6
Terrence F Meehan, Nathalie Conte, Theodore Goldstein, Giorgio Inghirami, Mark A Murakami, Sebastian Brabetz, Zhiping Gu, Jeffrey A Wiser, Patrick Dunn, Dale A Begley, Debra M Krupke, Andrea Bertotti, Alejandra Bruna, Matthew H Brush, Annette T Byrne, Carlos Caldas, Amanda L Christie, Dominic A Clark, Heidi Dowst, Jonathan R Dry, James H Doroshow, Olivier Duchamp, Yvonne A Evrard, Stephane Ferretti, Kristopher K Frese, Neal C Goodwin, Danielle Greenawalt, Melissa A Haendel, Els Hermans, Peter J Houghton, Jos Jonkers, Kristel Kemper, Tin O Khor, Michael T Lewis, K C Kent Lloyd, Jeremy Mason, Enzo Medico, Steven B Neuhauser, James M Olson, Daniel S Peeper, Oscar M Rueda, Je Kyung Seong, Livio Trusolino, Emilie Vinolo, Robert J Wechsler-Reya, David M Weinstock, Alana Welm, S John Weroha, Frédéric Amant, Stefan M Pfister, Marcel Kool, Helen Parkinson, Atul J Butte, Carol J Bult
Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29069448/asymmetric-cell-division-requires-specific-mechanisms-for-adjusting-global-transcription
#7
Adriana Mena, Daniel A Medina, José García-Martínez, Victoria Begley, Abhyudai Singh, Sebastián Chávez, Mari C Muñoz-Centeno, José E Pérez-Ortín
Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric cell division that can generate sibling cell size differences. Whereas physical asymmetric division mechanisms and cell fate consequences have been investigated, the specific problem caused by asymmetric division at the transcription level has not yet been addressed. In symmetrically dividing cells the nascent transcription rate increases in parallel to cell volume to compensate it by keeping the actual mRNA synthesis rate constant...
October 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29049061/the-art-of-parenting-at-night
#8
Jessica Begley, Kelley Bowden
No abstract text is available yet for this article.
November 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29043247/clinic-based-mobile-health-decision-support-to-enhance-adult-epilepsy-self-management-an-intervention-mapping-approach
#9
Ross Shegog, Charles E Begley
INTRODUCTION: Epilepsy is a neurological disorder involving recurrent seizures. It affects approximately 5 million people in the U.S. To optimize their quality of life people with epilepsy are encouraged to engage in self-management (S-M) behaviors. These include managing their treatment (e.g., adhering to anti-seizure medication and clinical visit schedules), managing their seizures (e.g., responding to seizure episodes), managing their safety (e.g., monitoring and avoiding environmental seizure triggers), and managing their co-morbid conditions (e...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29040466/outer-inflammatory-protein-a-oipa-of-helicobacter-pylori-is-regulated-by-host-cell-contact-and-mediates-caga-translocation-and-interleukin-8-response-only-in-the-presence-of-a-functional-cag-pathogenicity-island-type-iv-secretion-system
#10
Danielle N Horridge, Allison A Begley, June Kim, Neeraja Aravindan, Kexin Fan, Mark H Forsyth
OipA is a phase-variable virulence factor of Helicobacter pylori. Mutations in oipA to turn the gene phase on in a cag pathogenicity island (PAI)-negative strain of H. pylori (J68) or phase off in a cag PAI-positive strain (26695) demonstrated that phase on oipA alleles in both strains had both increased oipA mRNA and human gastric adenocarcinoma (AGS) cell adherence compared to isogenic oipA phase off mutants. An oipA phase off mutant of H. pylori 26695 demonstrated decreased IL-8 secretion by AGS cells and failure to translocate the cag PAI effector CagA...
November 30, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29022131/feedback-regulation-of-ribosome-assembly
#11
REVIEW
Jesús de la Cruz, Fernando Gómez-Herreros, Olga Rodríguez-Galán, Victoria Begley, María de la Cruz Muñoz-Centeno, Sebastián Chávez
Ribosome biogenesis is a crucial process for growth and constitutes the major consumer of cellular resources. This pathway is subjected to very stringent regulation to ensure correct ribosome manufacture with a wide variety of environmental and metabolic changes, and intracellular insults. Here we summarise our current knowledge on the regulation of ribosome biogenesis in Saccharomyces cerevisiae by particularly focusing on the feedback mechanisms that maintain ribosome homeostasis. Ribosome biogenesis in yeast is controlled mainly at the level of the production of both pre-rRNAs and ribosomal proteins through the transcriptional and post-transcriptional control of the TORC1 and protein kinase A signalling pathways...
October 11, 2017: Current Genetics
https://www.readbyqxmd.com/read/29018119/globally-important-haptophyte-algae-use-exogenous-pyrimidine-compounds-more-efficiently-than-thiamin
#12
Magdalena A Gutowska, Brateen Shome, Sebastian Sudek, Darcy L McRose, Maria Hamilton, Stephen J Giovannoni, Tadhg P Begley, Alexandra Z Worden
Vitamin B1 (thiamin) is a cofactor for critical enzymatic processes and is scarce in surface oceans. Several eukaryotic marine algal species thought to rely on exogenous thiamin are now known to grow equally well on the precursor 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), including the haptophyte Emiliania huxleyi Because the thiamin biosynthetic capacities of the diverse and ecologically important haptophyte lineage are otherwise unknown, we investigated the pathway in transcriptomes and two genomes from 30 species representing six taxonomic orders...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/28994435/hierarchical-cobalt-nitride-and-oxide-co-doped-porous-carbon-nanostructures-for-highly-efficient-and-durable-bifunctional-oxygen-reaction-electrocatalysts
#13
Kyung Jin Lee, Dong Yun Shin, Ayeong Byeon, Ahyoun Lim, Young Suk Jo, Alina Begley, Dong-Hee Lim, Yung-Eun Sung, Hyun S Park, Keun Hwa Chae, Suk Woo Nam, Kwan-Young Lee, Jin Young Kim
Here we report the preparation of hollow microspheres with a thin shell composed of mixed cobalt nitride (Co-N) and cobalt oxide (Co-O) nanofragments encapsulated in thin layers of nitrogen-doped carbon (N-C) nanostructure (Co-N/Co-O@N-C) arrays with enhanced bifunctional oxygen electrochemical performance. The hybrid structures are synthesized via heat treatment of N-doped hollow carbon microspheres with cobalt nitrate, and both the specific ratio of these precursors and the selected annealing temperature are found to be the key factors for the formation of the unique hybrid structure...
October 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28968521/irish-and-new-zealand-midwives-expertise-at-preserving-the-perineum-intact-the-meppi-study-perspectives-on-preparations-for-birth
#14
Valerie Smith, Karen Guilliland, Lesley Dixon, Mary Reilly, Caroline Keegan, Colette McCann, Cecily Begley
OBJECTIVES: perineal trauma during birth can result in short or long term morbidity for women. Internationally, rates of episiotomy and severe perineal tears vary considerably. In New Zealand, in 2011, and in a trial of midwife-led care in Ireland, episiotomy rates were found to be considerably lower than those in many other countries. A qualitative exploratory study was undertaken to ascertain how midwives achieve these low rates, in these countries and settings. DESIGN AND PARTICIPANTS: a qualitative exploratory study was conducted...
September 20, 2017: Midwifery
https://www.readbyqxmd.com/read/28935579/mechanisms-imaging-and-structure-of-tear-film-breakup
#15
REVIEW
P Ewen King-Smith, Carolyn G Begley, Richard J Braun
Tear film breakup (BU) is an important aspect of dry eye disease, as a cause of ocular aberrations, irritation and ocular surface inflammation and disorder. Additionally, measurement of breakup time, BUT, is a common clinical test for dry eye. The current definition of BUT is subjective; here, a more objective concept of "touchdown" - the moment when the lipid layer touches down on the corneal surface - is proposed as an aid to understanding processes in early and late stages of BU development. Models of BU have generally been based on the assumption that a single mechanism is involved...
September 18, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28929629/the-emergency-surgical-airway
#16
Jonathan L Begley, Ben Butson, Paul Kwa
No abstract text is available yet for this article.
October 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28901245/investigation-into-perfluoroalkyl-substances-pfass-in-a-cranberry-bog-method-development-and-sampling-results
#17
Susan Genualdi, Nahyun Jeong, Lowri deJager, Timothy Begley
The contamination of groundwater and surface water from previous uses of perfluoroalkyl substances (PFASs), particularly products containing the contaminants perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), has become a concern for drinking water and as a potential exposure route to the food supply. In 2016, the Food and Drug Administration (FDA) was asked to investigate a bog in Massachusetts where the surface water was believed to be contaminated with PFASs. As a result, a method was developed for the analysis of PFASs in cranberries, and water and fruit from the affected bog were evaluated...
September 13, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28894253/atm-deficiency-increases-genomic-instability-and-metastatic-potential-in-a-mouse-model-of-pancreatic-cancer
#18
Yiannis Drosos, David Escobar, Ming-Yi Chiang, Kathryn Roys, Virginia Valentine, Marc B Valentine, Jerold E Rehg, Vaibhav Sahai, Lesa A Begley, Jianming Ye, Leena Paul, Peter J McKinnon, Beatriz Sosa-Pineda
Germline mutations in ATM (encoding the DNA-damage signaling kinase, ataxia-telangiectasia-mutated) increase Familial Pancreatic Cancer (FPC) susceptibility, and ATM somatic mutations have been identified in resected human pancreatic tumors. Here we investigated how Atm contributes to pancreatic cancer by deleting this gene in a murine model of the disease expressing oncogenic Kras (Kras(G12D)). We show that partial or total ATM deficiency cooperates with Kras(G12D) to promote highly metastatic pancreatic cancer...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875370/how-prepared-are-pharmacists-to-support-atrial-fibrillation-patients-in-adhering-to-newly-prescribed-oral-anticoagulants
#19
Nadya Hamedi, Filipa Alves da Costa, Robert Horne, Michael Levitan, Amanda Begley, Sotiris Antoniou
Background The New Medicines Service (NMS) was implemented in the United Kingdom in 2011 and first evaluated in 2014, showing 10% increase on adherence. Objective To assess community pharmacists' current practice, knowledge and confidence in supporting patients' adherence as part of the NMS for patients on Oral Anti-Coagulants (OACs) for stroke prevention in Atrial Fibrillation. Setting Community pharmacists in London. Method An online cross-sectional survey was sent to pharmacists from their Local Pharmaceutical Committees and advertised by the Royal Pharmaceutical Society...
December 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28805432/strain-dependent-sex-differences-in-a-long-term-forced-swim-paradigm
#20
José Colom-Lapetina, Sabrina L Begley, Megan E Johnson, Kristina J Bean, Whitney N Kuwamoto, Rebecca M Shansky
Women are twice as likely as men to suffer from trauma- and stressor-related disorders. The development of improved therapeutic interventions is contingent upon a more complete grasp of both the neural and behavioral dynamics of the stress response in females. The rodent forced swim test (FST) is a valuable animal model for exploring the neurobiological mechanisms responsible for selection of active and passive responses to inescapable stressors, but it is often neglected in 2-day FST studies is the dissociation of innate (Day 1) versus learned (Day 2) coping responses...
October 2017: Behavioral Neuroscience
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