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https://www.readbyqxmd.com/read/27897190/versatile-sensitive-liquid-chromatography-mass-spectrometry-implementation-of-10%C3%A2-%C3%AE-m-ot-columns-suitable-for-small-molecules-peptides-and-proteins
#1
T Vehus, H Roberg-Larsen, J Waaler, S Aslaksen, S Krauss, S R Wilson, E Lundanes
We have designed a versatile and sensitive liquid chromatographic (LC) system, featuring a monolithic trap column and a very narrow (10 μm ID) fused silica open tubular liquid chromatography (OTLC) separation column functionalized with C18-groups, for separating a wide range of molecules (from small metabolites to intact proteins). Compared to today's capillary/nanoLC approaches, our system provides significantly enhanced sensitivity (up to several orders) with matching or improved separation efficiency, and highly repeatable chromatographic performance...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853497/imaging-findings-in-patients-with-granulomatous-mastitis
#2
Pelin Seher Oztekin, Gamze Durhan, Pinar Nercis Kosar, Serap Erel, Sema Hucumenoglu
BACKGROUND: Granulomatous mastitis (GM) is a rare inflammatory breast disease that may mimic the clinical characteristics and radiologic imaging findings of breast carcinoma. Considering the importance of making a correct diagnosis, careful radiologic evaluations and recognition of imaging features are necessary. OBJECTIVES: The aim of this study was to review the radiological findings and diagnostic value of the imaging in GM. PATIENTS AND METHODS: This retrospective study involved a total of 29 patients who were diagnosed with GM between 2009 and 2013 and who underwent mammography (MG) and/or ultrasound (US) examination in addition to magnetic resonance imaging (MRI) before diagnosis...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27832842/flat-epithelial-atypia-on-core-needle-biopsy-must-we-surgically-excise
#3
A A Acott, A T Mancino
: Breast flat epithelial atypia (FEA) often coexists with more aggressive pathology and excision is currently recommended when diagnosed by core needle biopsy (CNB). Recent studies suggest isolated FEA has a low association with carcinoma and may warrant close surveillance. A radiology database containing 2189 breast CNB was reviewed for isolated FEA or FEA in combination with atypical pathology. 79 patients had FEA. There were 48/79 with isolated FEA and 31/79 concomitant FEA with ADH, ALH, or LCIS...
October 29, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27802189/a-case-of-multicentric-low-grade-neuroendocrine-breast-tumor-with-an-unusual-histological-pattern
#4
Antonio D'Antonio, Maria Addesso, Domenico Memoli, Annamaria Cascone, Luigi Cremone
Neuroendocrine features are detectable in carcinomas of the breast either as scattered cells, that are recognized by their expression of neuroendocrine cell markers. Instead, pure breast carcinomas with neuroendocrine features (NEBC) are very rare and represent <1% of all breast cancer. Usually NEBC may be well or poorly differentiated and more frequent in older woman. These tumors showed variable histological pattern but a common feature is represented by expression of neuroendocrine markers. Here we report a case of a primary multicentric low-grade neuroendocrine carcinoma of the breast presented because of its rarity and for the unusual tubular and cribriform pattern resembling a well-differentiated conventional breast carcinoma...
October 14, 2016: Breast Disease
https://www.readbyqxmd.com/read/27769548/characteristics-and-treatment-of-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-43-485-cases-from-the-national-cancer-database-treated-in-2010-and-2011
#5
Brigid K Killelea, Anees B Chagpar, Nina R Horowitz, Donald R Lannin
BACKGROUND: Although identification of human epidermal growth factor receptor 2 (Her2) positive breast cancer represents one of the greatest advances over the past 3 decades, it has not been studied extensively on a national level. METHODS: The National Cancer Database is a joint project of the American Cancer Society and the American College of Surgeons and contains data on about 70% of the cancer cases in the United States. Data on Her2 have been collected since 2010 and was used for this study...
July 21, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27742372/a-novel-combination-of-two-minimally-invasive-surgical-techniques-in-the-management-of-refractory-radiation-necrosis-technical-note
#6
Ghaith Habboub, Mayur Sharma, Gene H Barnett, Alireza M Mohammadi
BACKGROUND: Minimally-invasive approaches are attractive alternative to standard craniotomy for large intracranial tumors with potentially lesser morbidity. In this report, we describe a sequential combination of two minimally-invasive surgical techniques to treat a large intracranial tumor. CLINICAL PRESENTATION: A 49year-old woman presented with a history of breast cancer and large left parietal metastasis with significant perilesional edema. This was initially managed by whole brain radiation therapy and stereotactic radiosurgery...
October 11, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27718417/initial-experience-of-automated-breast-volume-scanning-abvs-and-ultrasound-elastography-in-predicting-breast-cancer-subtypes-and-staging
#7
Xiao-Lei Wang, Lin Tao, Xian-Li Zhou, Hong Wei, Jia-Wei Sun
OBJECTIVES: Breast cancer is a heterogeneous disease consisting of distinct histopathological subtypes with different clinical outcomes. In this article, we identified the automated breast volume scanning (ABVS) and shear wave velocity (SWV) characteristics of different pathological types of breast carcinoma. METHODS: A retrospective review of both ABVS and SWV imaging of 118 consecutive breast masses was performed. The imaging features of both techniques were assessed with reference to histopathological results...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27630851/a-clinicopathological-study-of-benign-phyllodes-tumour-of-breast-with-emphasis-on-unusual-features
#8
Kishori Moni Panda, Reena Naik
INTRODUCTION: Benign Phyllodes Tumours (PTs) are rare fibroepithelial neoplasms that resemble fibroadenoma. But unlike fibroadenoma, benign PT can recur and both stromal & epithelial components can progress to malignancy. Contrary to earlier belief that benign PT is a stromal neoplasm and possibly arises from fibroadenoma, more recent molecular studies have suggested that both stroma and epithelium can become neoplastic. Sometimes, benign PT can occur synchronously with fibroadenoma. Here histomorphologic analysis of eleven cases of benign PT are presented including some unusual features...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27583877/urachal-adenocarcinoma-that-metastasized-to-breast-was-misinterpreted-as-primary-breast-mucinous-carcinoma-a-rare-case-report-and-literature-review
#9
Xiang-Rong Zhao, Chao Gao, Yong Zhang, Lei Kong, Wei Qu, Jia Li, Yong-Sheng Gao, Yong-Hua Yu
BACKGROUND: The urachus is a vestigial tubular structure that connects the urinary bladder to the allantois during early embryonic development. Urachal carcinoma develops in the urachus, which is an embryological remnant of the urogenital sinus and allantois. The estimated annual incidence of urachal carcinoma in the general population is 0.01% of all cancers in adults. Moreover, urachal carcinoma accounts for 0.34% to 0.7% of all bladder carcinoma cases. And breast metastasis is extremely rarer...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27553658/pure-invasive-micropapillary-carcinoma-of-the-esophagogastric-junction-with-lymph-nodes-and-liver-metastasis
#10
Takuya Hattori, Kazuhiro Sentani, Yui Hattori, Naohide Oue, Wataru Yasui
Invasive micropapillary carcinoma (IMPC), an aggressive variant of adenocarcinoma, is associated with a poor prognosis. Although IMPC has been reported to occur in various organs, pure IMPC has only been reported in the breast, pancreas and colon. There are no reports of IMPC of the esophagogastric junction (EGJ). According to previous reports on gastric IMPC, IMPC occupied, at most, 90 % of the whole tumor. IMPC is reported to occur least frequently in the gastric cardia. We herein report a rare case of pure IMPC of the EGJ...
October 2016: Pathology International
https://www.readbyqxmd.com/read/27551331/muc4-is-negatively-regulated-through-the-wnt-%C3%AE-catenin-pathway-via-the-notch-effector-hath1-in-colorectal-cancer
#11
Priya Pai, Satyanarayana Rachagani, Punita Dhawan, Yuri M Sheinin, Muzafar A Macha, Asif Khurshid Qazi, Seema Chugh, Moorthy P Ponnusamy, Kavita Mallya, Ramesh Pothuraju, Surinder K Batra
MUC4 is a transmembrane mucin lining the normal colonic epithelium. The aberrant/de novo over-expression of MUC4 is well documented in malignancies of the pancreas, ovary and breast. However, studies have reported the loss of MUC4 expression in the majority of colorectal cancers (CRCs). A MUC4 promoter analysis showed the presence of three putative TCF/LEF sites, implying a possible regulation by the Wnt/β-catenin pathway, which has been shown to drive CRC progression. Thus, the objective of our study was to determine whether MUC4 is regulated by β-catenin in CRC...
May 2016: Genes & Cancer
https://www.readbyqxmd.com/read/27493488/correlation-between-ultrasound-findings-of-tumor-margin-and-clinicopathological-findings-in-patients-with-invasive-ductal-carcinoma-of-the-breast
#12
Naoko Sannomiya, Yuiko Hattori, Naoyuki Ueda, Akira Kamida, Yuki Koyanagi, Haruki Nagira, Saeko Ikunishi, Kenta Shimabayashi, Yuki Hashimoto, Aya Murata, Kengo Sato, Yumi Hirooka, Keiko Hosoya, Kiyosuke Ishiguro, Yoko Murata, Yasuaki Hirooka
BACKGROUND: Breast ultrasound findings regarding tumor margins are crucial in judging whether a tumor is malignant or benign. However, the relationships between the margins and clinicopathological characteristics remain largely unknown. In this study, we examined the clinicopathological characteristics of patients with invasive ductal carcinoma whose ultrasound images showed either well-defined and rough or indistinct margins. METHODS: Of all consecutive patients diagnosed with invasive ductal carcinoma at the Division of Breast and Endocrine Surgery of Tottori University Hospital from January 2012 to December 2014, 122 patients whose ultrasound images showed either "well-defined and rough" or "indistinct" tumor margins were included in this study...
June 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/27438523/tubular-lactating-and-ductal-adenomas-are-devoid-of-med12-exon2-mutations-and-ductal-adenomas-show-recurrent-mutations-in-gnas-and-the-pi3k-akt-pathway
#13
Anna-Lena Volckmar, Jonas Leichsenring, Christa Flechtenmacher, Nicole Pfarr, Udo Siebolts, Martina Kirchner, Jan Budczies, Michael Bockmayr, Kathrin Ridinger, Katja Lorenz, Esther Herpel, Aurelia Noske, Wilko Weichert, Frederick Klauschen, Peter Schirmacher, Roland Penzel, Volker Endris, Albrecht Stenzinger
Adenomas of the breast are rare benign tumors although single cases with malignant behavior have been reported. However, the genetic basis of these tumors is unknown. Employing targeted next generation sequencing of 50 cancer-related genes as well as Sanger sequencing, we profiled a cohort of 18 mammary adenomas comprising 9 ductal, 6 tubular, and 3 lactating adenoma. Missense mutations were detected in 8 of the 18 cases (44%). Specifically, five (56%) ductal adenomas and three (50%) tubular adenomas harbored mutated genes...
January 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27400918/mammary-analog-secretory-carcinoma-masc-involving-the-thyroid-gland-a-report-of-the-first-3-cases
#14
Jennifer Dettloff, Raja R Seethala, Todd M Stevens, Margaret Brandwein-Gensler, Barbara A Centeno, Kristen Otto, Julia A Bridge, Justin A Bishop, Marino E Leon
Salivary gland-type tumors have been rarely described in the thyroid gland. Mammary Analog Secretory Carcinoma (MASC) is a recently defined type of salivary gland carcinoma characterized by a t(12;15)(p13;q25) resulting in an ETV6-NTRK3 fusion gene. We report 3 cases of MASC involving the thyroid gland without clinical evidence of a salivary gland or breast primary; the clinico-pathologic characteristics are reviewed. Assessment for rearrangement of the ETV6 (12p13) locus was conducted by fluorescence in situ hybridization (FISH) on representative FFPE sections using an ETV6 break apart probe (Abbott Molecular, Des Plaines, IL, USA)...
July 11, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27374279/sebaceous-lymphadenoma-of-the-thymus-a-clinicopathologic-and-immunohistochemical-study-of-2-cases
#15
Annikka Weissferdt, Neda Kalhor, Cesar A Moran
Two cases of primary sebaceous lymphadenoma of the thymus are presented. The patients were a man and a woman 58 and 77 years old, respectively. The female patient had a history of breast carcinoma and on follow-up was identified to have an anterior mediastinal mass; the male patient did not have any history of malignancy, and the tumor was discovered during a chest radiographic evaluation when the patient presented with symptoms of fatigue, chest pain, and dyspnea. Histologically, both lesions were characterized by the presence of solid-cystic epithelial islands in a prominent lymphocytic background...
October 2016: Human Pathology
https://www.readbyqxmd.com/read/27316791/human-biliverdin-reductase-promotes-emt-through-the-erk1-2-signal-pathway-in-breast-cancer
#16
Min Zhang, Shasha Song, Zhi Yi, Xijuan Zhao, Li Fu, Lin Wang, Cui Ma, Min Mao, Yan Xing, Daling Zhu
Epithelial-to-mesenchymal transition (EMT) plays an important role in the development of the invasive and metastatic potentials of breast cancer cells during progression. Human biliverdin reductase (hBVR), an enzyme in the heme metabolism pathway, is involved in hypoxia-induced renal tubular EMT. However, whether hBVR contributes to the EMT of breast cancer remains unclear. Here, we used breast cancer cell lines (MCF-7, T-47D) and normal breast epithelial cells (MCF-10A) to explore the potential role of hBVR in the EMT of breast cancer...
October 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27305881/tubular-carcinoma-of-the-breast-a-single-institution-s-experience-of-a-favorable-prognosis
#17
William Boyan, Brian Shea, Michael Farr, Manpreet Kohli, Ernest Ginalis
Tubular carcinoma is a subtype of invasive breast cancer that comprises 1 to 4 per cent of invasive breast cancers. Prior studies show nearly 100 per cent 15 year survival rate for tubular carcinoma compared to the 89.2 per cent five year survival of all breast cancers. These encouraging statistics beg the question should tubular cancers be treated as other invasive cancers, or can some patients be spared an invasive procedure or the side effects of adjuvant therapy? Fifty-seven cases of tubular carcinoma over 16 years were analyzed...
June 2016: American Surgeon
https://www.readbyqxmd.com/read/27262487/predictive-pathology-in-the-target-therapy-era-in-breast-cancer
#18
Anna Sapino
The concept of "precision medicine", where therapy is personalized to unique disease and host characteristics, is currently revolutionizing treatment strategies in oncology. A key point in this concept is the fact that several so-called "targeted drugs" may only be effective when tumors exhibit characteristic molecular features. This implies that companion diagnostic tests should be performed before treatment. There is evidence suggesting that the first step in predictive pathology is represented by morphology...
June 1, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27225150/adenoid-cystic-carcinoma-of-breast-clinicopathologic-study-of-seven-cases
#19
Raabia Nizamuddin, Nasir Ud Din, Romana Idrees, Naila Kayani
Adenoid cystic carcinoma (ACC) of the breast is a rare type of tumor. Our objective was to determine the clinicopathologic features of breast ACC. We reviewed slides of breast ACC reported during 12 years. Seven cases were identified. Age ranged from 38 to 59 years (mean = 47 years). Mean tumor size was 2.3 cm (range 1.2 to 4 cm). Histologically, dominant cribriform pattern was seen in 4 cases, solid in 2 and tubular in one case. Mitotic figures ranged from 2 to 22/10 HPFs. Grades I and II were seen in 3 cases each while 1 was grade III...
May 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27180060/mammary-analogue-secretory-carcinoma-of-salivary-glands-a-clinicopathologic-study-of-11-cases
#20
Nasir Ud Din, Saira Fatima, Naila Kayani
Mammary analogue secretory carcinoma (MASC) is a recently described tumor sharing the histologic, immunohistochemical, and molecular profile of secretory carcinoma of breast. We aimed to evaluate the morphologic and histochemical features needed/required for the diagnosis of MASC without adjunct of molecular analysis. Six retrospective cases suspicious for MASC and 5 prospective cases reported as MASC were included in the study. Molecular analysis of ETV6 by fluorescence in situ hybridization was performed at the University of Pittsburg, USA...
June 2016: Annals of Diagnostic Pathology
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