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retinal artery occlusion

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https://www.readbyqxmd.com/read/29241762/eltrombopag-for-advanced-myelodysplastic-syndromes-or-acute-myeloid-leukaemia-and-severe-thrombocytopenia-aspire-a-randomised-placebo-controlled-phase-2-trial
#1
Moshe Mittelman, Uwe Platzbecker, Boris Afanasyev, Sebastian Grosicki, Raymond S M Wong, Achilles Anagnostopoulos, Benjamin Brenner, Claudio Denzlinger, Giuseppe Rossi, Arnon Nagler, Regina Garcia-Delgado, Maria Socorro O Portella, Zewen Zhu, Dominik Selleslag
BACKGROUND: Thrombocytopenia is a life-threatening complication in patients with advanced myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). In this study (ASPIRE), we aimed to assess eltrombopag, an oral thrombopoietin receptor agonist, for thrombocytopenia (grade 4) treatment in adult patients with advanced MDS or AML. METHODS: ASPIRE consisted of an open-label, double-blind phase for 8 weeks and a randomised, double-blind phase (parts 1 and 2, reported here) for 12 weeks, and an open-label extension (part 3)...
December 11, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29241233/hyperbaric-oxygen-in-the-treatment-of-acute-retinal-artery-occlusion
#2
Mark J Elder, John A Rawstron, Michael Davis
INTRODUCTION: Acute retinal artery occlusion (ARAO) is a major cause of sudden, painless visual loss, often leaving no useful vision in the affected eye. Its incidence is cited at 0.85 per 100,000 persons per year but may be higher because of under-reporting. The natural history is difficult to study, but a spontaneous resolution rate of < 1-8% for acute, non-arteritic ARAO has been cited. Occurrence in an only eye is devastating for the patient. There is currently no consensus regarding management of ARAO and little evidence to support any treatment modality...
December 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29239920/a-rare-complication-after-septoplasty-visual-loss-due-to-right-retinal-artery-spasm
#3
Celal Günay, Gökhan Altin, Burak Kersin, Mahmut Odabaşi
Septoplasty is a commonly used procedure for correcting septal cartilage deformities. Hemorrhage, abscesses, scaling, adhesions, and scar tissue are often seen after the operation of the septoplasty, but temporary or permanent visual loss due to local anesthetic use has been reported very rarely in the literature. The authors also aimed to present a female patient with retinal artery spasm in the right eye after septoplasty in this article. A 27-year-old female patient was admitted to the authors' clinic with long-standing nasal obstruction and postnasal drip...
December 12, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29236169/current-treatment-of-central-retinal-artery-occlusion-a-national-survey
#4
Teddy S Youn, Patrick Lavin, Morgan Patrylo, Joseph Schindler, Howard Kirshner, David M Greer, Matthew Schrag
BACKGROUND: Central retinal artery occlusion (CRAO) is an ophthalmological emergency, the retinal analog of a stroke. To date there is no consensus or national guidelines on how this disorder should be managed. As academic neurologists and ophthalmologists treat CRAO frequently, we set out to understand how these clinicians approach patients with CRAO with a national survey. METHODS: We identified university-associated teaching hospitals offering vascular neurology, neuro-ophthalmology and/or retina fellowships in the US and asked the directors of the programs to respond to questions in an open response format to profile the acute management of CRAO at their institution...
December 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29225873/migration-of-emboli-in-the-retinal-artery-case-report
#5
Alexandr Stepanov, Marketa Machackova, Tereza Rehakova, Nada Jiraskova, Jan Lestak
Branch retinal artery occlusion (BRAO) is a prevalent vascular occlusive disorder of the eye. In transient BRAO, an embolus temporarily blocks the vessel and then moves on resulting in recovery of blood circulation. In this case, we have documented migration of the embolus with recovery of perfusion of the retina and improvement of visual acuity in a patient with transient BRAO. Early diagnosis and fast action are important in the case of patients with retinal artery occlusion.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29209435/diseases-potentially-related-to-flammer-syndrome
#6
REVIEW
Katarzyna Konieczka, Carl Erb
Flammer syndrome (FS) is a prevalent and mostly benign condition. Subjects with FS seem to have a good life expectancy. Nevertheless, FS subjects are at increased risk for certain diseases, mainly when they are challenged by psychological stress or other stimuli such as coldness. FS is related to ocular diseases, such as normal-tension glaucoma, retinitis pigmentosa, central serous chorioretinopathy, optic nerve compartment syndrome, Leber's hereditary optic neuropathy, arterial or venous occlusions in the retina, and choroid and optic nerve head, despite the absence of classical vascular risk factors...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29196198/neurosurgical-modeling-of-retinal-ischemia-reperfusion-injury
#7
Alireza P Shabanzadeh, Philippe M D'Onofrio, Philippe P Monnier, Paulo D Koeberle
BACKGROUND: A reliable model of ischemia-reperfusion is required to evaluate the efficacy and safety of neuroprotective therapies for stroke. We present a novel reproducible pterygopalatine-ophthalmic artery ligation model of ischemia-reperfusion injury in the retina. METHODS: Rats were subjected to ophthalmic artery/meningeal sheath ligation (OAML-standard method) or clamping of the pterygopalatine-ophthalmic artery (OAC-new method) for 30 minutes. Retinal ganglion cell (RGC) survival was assessed by prelabeling with FluoroGold (FG) (Santa Cruz Biotechnology, CA, USA) and RNA-binding protein with multiple splicing (RBPMS) at 14 days after ischemia, and all results were compared with a sham group (n = 7 in each group)...
November 29, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29193621/review-of-the-association-between-retinal-microvascular-characteristics-and-eye-disease
#8
REVIEW
Alexander Newman, Nicholas Andrew, Robert Casson
Computerized retinal imaging technologies enable the static and dynamic measurement of a range of retinal microvascular parameters. Large population-based studies have reported associations between these microvascular indices and various ophthalmic diseases including diabetes, age-related macular degeneration, retinal artery embolism, retinal vein occlusion, glaucoma, and non-glaucomatous optic neuropathies. Increasingly sophisticated imaging and analysis techniques have the potential to provide relevant clinical information regarding disease risk and progression; however, further studies are required to verify associations and strengthen the predictive power of these techniques...
November 29, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29191536/the-enigma-of-orbital-compartment-syndrome-after-lumbar-spine-surgery-in-the-prone-position-case-report-and-literature-review
#9
Jorge Luiz Amorim Correa, Marcus André Acioly
Perioperative visual loss (POVL) after spinal surgery is a devastating complication for both the patient and the surgical team. Two major causes are known: ischemic optic neuropathy (ION) and central retinal artery occlusion (CRAO). The traditional understanding of CRAO has been consistently related to the occurrence of periocular trauma and signs of increased intraorbital pressure in addition to visual loss. Such orbital signs are, however, not a feature of any common POVL syndrome. A 55-year-old woman underwent prolonged lumbar decompression and fusion for spinal stenosis under general anesthesia in the prone position...
November 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29190171/associations-with-retinal-vascular-occlusions-in-a-diverse-urban-population
#10
Eric J Schwaber, Nia Fogelman, Ethan K Sobol, Devi Mehrotra, Jonathan A Powell, Umar Mian, David C Gritz
PURPOSE: Retinal vascular occlusions can lead to sudden and permanent visual impairment or blindness. Few epidemiological studies on retinal vascular occlusions have been conducted, especially on diverse populations. METHODS: This is a retrospective case-control study of all incident retinal vascular occlusions occurring during a three and one-half year study period at Montefiore Medical Center, capturing all potential cases by diagnosis codes. Patients with retinal venous occlusions (RVO) and retinal arterial occlusions (RAO) were analyzed separately and compared to age-matched control groups...
November 30, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29176528/paracentral-acute-middle-maculopathy-in-a-perivenular-fern-like-distribution-with-en-face-optical-coherence-tomography
#11
Sean T Garrity, Victoria L Tseng, David Sarraf
PURPOSE: To report a case of central retinal vein occlusion resulting in a perivenular pattern of paracentral acute middle maculopathy lesions best identified with en face optical coherence tomography (OCT). METHODS: Retrospective case report. Optos ultra-widefield fluorescein angiography, spectral domain OCT, en face OCT, and OCT angiography were performed. RESULTS: A 41-year-old man presented with decreased vision in the right eye for 2 weeks...
November 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29162667/reperfusion-of-occluded-branch-retinal-arteries-by-transluminal-nd-yag-laser-embolysis-combined-with-intravenous-thrombolysis-of-urokinase
#12
Fang Chai, Shanshuang Du, Xiquan Zhao, Runsheng Wang
Purpose.  To report successful treatment with transluminal Nd:YAG laser embolysis (TYE) combined with urokinase thrombolysis for reperfusion of occluded branch retinal arteries with visible emboli. Methods A total of 34 eyes from 34 patients with acute, severe vision loss secondary to a branch retinal artery occlusion with visible emboli and retinal whitening were examined. Each patient was administered TYE therapy, which focused on the embolus, using an ocular contact lens; a 0.3-0.9 mJ laser pulse was delivered directly and gradually according to the reaction...
November 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29156466/-retinal-artery-occlusions
#13
Gabriele E Lang, Stefan J Lang
Retinal artery occlusions are acute vascular diseases. Very often they are caused by an embolisation. Rarely a thrombosis is caused by an arteriitis. In the acute phase diagnosis in most of the cases can be made by ophthalmoscopy due to the whitish retinal edema and in central retinal artery occlusion the cherry red spot. Difficulties in making the diagnosis can occur in the chronic stage, especially after reperfusion of the retinal vessels, when the fundus colour returned to normal again. Several diagnostic procedures help to make the diagnosis...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29146987/homocysteine-in-retinal-artery-occlusive-disease-a-meta-analysis-of-cohort-studies
#14
Xuetao Huang, Yezhen Yang, Yiqin Duan, Yi-Qun Kuang, Ding Lin
Few studies have reported the relationship between retinal artery occlusion (RAO) and plasma homocysteine (Hcy) levels. Our goal was to evaluate the association between the plasma Hcy level and the risk of RAO disease. Several databases were searched for all published studies that involved Hcy and RAO. Six studies evaluated hyperhomocysteinemia (hHcy) in retinal artery occlusion patients and controls; the incidence of hHcy in patients with RAO was higher than the control and the pooled odds ratio (OR) was 6...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133663/combined-central-retinal-artery-and-vein-occlusion-with-optic-perineuritis-following-herpes-zoster-dermatitis-in-an-immunocompetent-child
#15
Reema Bansal, Ramandeep Singh, Aastha Takkar, Vivek Lal
A 15-year-old healthy boy developed acute, rapidly progressing visual loss in left eye following herpes zoster dermatitis, with a combined central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO), along with optic perineuritis. Laboratory tests were negative. Despite an empirical, intensive antiviral treatment with systemic corticosteroids, and vision could not be restored in the affected eye. Herpes zoster dermatitis, in an immunocompetent individual, may be associated with a combined CRAO and CRVO along with optic perineuritis, leading to profound visual loss...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133654/-dye-front-reciprocation-in-combined-central-retinal-vein-occlusion-with-cilioretinal-artery-infarction
#16
Raghav Ravani, Rohan Chawla, Shreyans Jain, Atul Kumar
No abstract text is available yet for this article.
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29121367/idiopathic-retinal-vasculitis-aneurysms-and-neuroretinitis-syndrome-presenting-with-branch-retinal-artery-occlusion
#17
Jennifer A Zacharia, Adam T Chin, Carl B Rebhun, Ricardo N Louzada, Mehreen Adhi, Emily D Cole, Carlos Moreira-Neto, Nadia K Waheed, Jay S Duker
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) is a rare syndrome affecting the retinal and optic disc vasculature. Diffuse retinal ischemia, macular edema, and neovascularization may lead to bilateral vision loss. The authors report a case of a 36-year-old woman presenting with branch retinal artery occlusion (BRAO) in her right eye who was subsequently diagnosed with IRVAN syndrome. She was treated with panretinal photocoagulation for peripheral retinal ischemia and pars plana vitrectomy for vitreous hemorrhage...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29120976/case-report-masquerading-large-vessel-giant-cell-arteritis
#18
Paul Jacquier, Raphael Wuarin, Carlo Chizzolini, Gabriele Thumann, Heimo Steffen, Argyrios Chronopoulos
SIGNIFICANCE: Large-vessel giant cell arteritis (GCA) can be a diagnostic dilemma for the eye care provider because it may not involve the typical cranial arteries. When any of its potential ocular complications are diagnosed, it is important to consider this unusual form of GCA. PURPOSE: To report an unusual ophthalmic presentation of large-vessel GCA with sequential bilateral anterior ischemic optic neuropathy and branch retinal artery occlusion. METHODS: A 65-year-old previously healthy woman experienced sequential bilateral anterior ischemic optic neuropathy with branch retinal artery occlusion in the absence of other signs and symptoms suggestive of cranial GCA...
November 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29095262/diurnal-variation-of-pulse-waveform-parameters-determined-by-laser-speckle-flowgraphy-on-the-optic-nerve-head-in-healthy-subjects
#19
Marie Fukami, Takeshi Iwase, Kentaro Yamamoto, Eimei Ra, Kenta Murotani, Hiroko Terasaki
To investigate the diurnal variation of the pulse waveform parameters determined by laser speckle flowgraphy (LSFG) on the optic nerve head (ONH) in healthy subjects.This prospective cross sectional study was conducted at Nagoya University Hospital. We studied 13 healthy volunteers whose mean age was 33.5 ± 7.6 years. Eight pulse waveform parameters on the ONH were determined by LSFG (LSFG-NAVI) every 3 hours from 6 AM to 12 PM. The intraocular pressure (IOP), systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) in the brachial artery were also recorded...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29071559/successful-retinal-blood-flow-augmentation-after-extracranial-intracranial-bypass
#20
Tackeun Kim, Min Jai Cho, Sang Jun Park, Moon-Ku Han, Davendra Hari Ojar, Chang Wan Oh, Jae Seung Bang
A 61-year-old woman visited us with recent onset right-side weakness. Magnetic resonance imaging showed ischemic changes at the left internal border zone due to occlusive disease affecting the left proximal internal carotid artery. Prompt oral dual antiplatelet therapy and intravenous fluid were administered with subsequent induced hypertension and without reperfusion therapy. Although the hemiparesis was improved, she complained of a new-onset transient left-side monocular visual loss. Fluorescein angiography confirmed delayed perfusion in the left eye...
October 25, 2017: Acta Neurochirurgica
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