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retinal necrosis

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https://www.readbyqxmd.com/read/28302155/a-prospective-randomised-placebo-controlled-double-masked-three-armed-multicentre-phase-ii-iii-trial-for-the-study-of-a-topical-treatment-of-ischaemic-central-retinal-vein-occlusion-to-prevent-neovascular-glaucoma-the-strong-study-study-protocol-for-a-randomised
#1
Katrin Lorenz, Yvonne Scheller, Katharina Bell, Franz Grus, Katharina A Ponto, Felix Bock, Claus Cursiefen, Jens Flach, Marta Gehring, Tunde Peto, Rufino Silva, Yossi Tal, Norbert Pfeiffer
BACKGROUND: Neovascular glaucoma (NVG) is rare, comprising only 3.9% of all glaucoma cases. The most common cause of NVG is ischaemic central retinal vein occlusion (iCRVO). NVG frequently results in blindness and painful end-stage glaucomatous damage leading to the need for enucleation. Currently, there is no preventive therapy for NVG following iCRVO. Rescue treatments have severe drawbacks. Accordingly, there is a great need for preventing the often visually devastating outcomes of NVG...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28301595/mir-146a-regulates-glucose-induced-upregulation-of-inflammatory-cytokines-extracellular-matrix-proteins-in-the-retina-and-kidney-in-diabetes
#2
Shali Chen, Biao Feng, Anu Alice Thomas, Subrata Chakrabarti
Hyperglycemic damage to the endothelial cells (ECs) leads to increased synthesis of inflammatory cytokines. We have previously shown miR-146a downregulation in ECs and in the tissues of diabetic mice. Here we investigated the role of miR-146a, in the production of specific inflammatory cytokines and extracellular matrix (ECM) proteins in retina and kidneys in diabetes. We generated an endothelial specific miR-146a overexpressing transgenic mice (TG). We investigated these mice and wild type (WT) controls with or without streptozotocin (STZ) induced diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28291869/neuroprotective-effects-of-omega-3-polyunsaturated-fatty-acids-in-a-rat-model-of-anterior-ischemic-optic-neuropathy
#3
Tassos Georgiou, Yao-Tseng Wen, Chung-Hsing Chang, Panagiotis Kolovos, Maria Kalogerou, Ekatherine Prokopiou, Anastasia Neokleous, Chin-Te Huang, Rong-Kung Tsai
Purpose: The purpose of this study was to investigate the therapeutic effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) administration in a rat model of anterior ischemic optic neuropathy (rAION). Methods: The level of blood arachidonic acid/eicosapentaenoic acid (AA/EPA) was measured to determine the suggested dosage. The rAION-induced rats were administered fish oil (1 g/day EPA) or phosphate-buffered saline (PBS) by daily gavage for 10 consecutive days to evaluate the neuroprotective effects...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28291069/two-cases-of-acute-retinal-necrosis-due-to-varicella-zoster-despite-prior-shingles-vaccination
#4
Eric J Weinlander, Angeline L Wang, Pimkwan Jaru-Ampornpan, Michael M Altaweel, T Michael Nork
PURPOSE: To review two cases of acute retinal necrosis in adults due to varicella zoster virus despite prior shingles vaccination. METHODS: Retrospective chart review. PATIENTS: A 62-year-old man and a 64-year-old man with unilateral acute retinal necrosis who had shingles vaccinations 16 and 7 months before their ocular symptoms. RESULTS: Polymerase chain reaction confirmation of varicella zoster virus in the anterior chambers of both patients...
March 13, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28282423/age-related-macular-degeneration-phenotypes-are-associated-with-increased-tumor-necrosis-alpha-and-subretinal-immune-cells-in-aged-cxcr5-knockout-mice
#5
Hu Huang, Ying Liu, Lei Wang, Wen Li
The role of chemokine receptor in age-related macular degeneration (AMD) remains elusive. The objective of this study is to investigate the role of chemokine receptor Cxcr5 in the pathogenesis of AMD. Cxcr5 gene expression levels (mRNA and protein) are higher in the retina and retinal pigment epithelium (RPE) of aged C57BL/6 wild type mice than younger ones. Vascular and glial cells express Cxcr5 and its ligand Cxcl13 in mouse retina. Aged Cxcr5 knockout (-/-) mice develop both early and late AMD-like pathological features...
2017: PloS One
https://www.readbyqxmd.com/read/28260360/-determination-of-cytomegalovirus-igg-synthesis-by-the-albumin-correction-in-the-aqueous-humor-of-posner-schlossmann-syndrome
#6
X L Wang, Z J Wang, L Tang, W W Cao, X H Sun
Objective: To evaluate the usefulness of albumin correction in determination of cytomegalovirus IgG in the aqueous humor of Posner-Schlossman syndrome (PSS) patients. Methods: Cases series studies. Forty-two patients (26 men and 16 women) who were diagnosed as PSS were enrolled from Oct. 2009 to Oct. 2015 at the Eye and ENT Hospital. During the same period, 20 patients with primary open-angle glaucoma (POAG) and 30 patients with bacterial endophthalmitis or retinal necrosis were enrolled as negative control group and inflammatory disease control group, respectively...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28251076/light-emitting-diode-induced-retinal-damage-and-its-wavelength-dependency-in-vivo
#7
Yu-Man Shang, Gen-Shuh Wang, David H Sliney, Chang-Hao Yang, Li-Ling Lee
AIM: To examine light-emitting-diode (LED)-induced retinal neuronal cell damage and its wavelength-driven pathogenic mechanisms. METHODS: Sprague-Dawley rats were exposed to blue LEDs (460 nm), green LEDs (530 nm), and red LEDs (620 nm). Electroretinography (ERG), Hematoxylin and eosin (H&E) staining, transmission electron microscopy (TEM), terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and immunohistochemical (IHC) staining, Western blotting (WB) and the detection of superoxide anion (O2(-)·), hydrogen peroxide (H2O2), total iron, and ferric (Fe(3+)) levels were applied...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28210097/epac1-agonist-decreased-inflammatory-proteins-in-retinal-endothelial-cells-and-loss-of-epac1-increased-inflammatory-proteins-in-the-retinal-vasculature-of-mice
#8
Li Liu, Youde Jiang, Adam Chahine, Elizabeth Curtiss, Jena J Steinle
PURPOSE: Increased inflammatory mediator levels are reported in diabetic retinopathy. We previously reported that β-adrenergic receptor agonists reduced inflammatory mediators in the diabetic retina; however, these agents cannot be given systemically. Here, we investigated whether Epac1 is key to the protective effects of β-adrenergic receptor agonists. METHODS: We cultured primary human retinal endothelial cells (RECs) in normal (5 mM) or high (25 mM) glucose and treated them with an Epac1-specific agonist...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28199833/fgf21-administration-suppresses-retinal-and-choroidal-neovascularization-in-mice
#9
Zhongjie Fu, Yan Gong, Raffael Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Steven S Meng, Samuel B Burnim, Nicholas J Saba, Thomas W Fredrick, Peyton C Morss, Ann Hellstrom, Saswata Talukdar, Lois E H Smith
Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. Using a mouse model of hypoxia-driven retinal neovascularization, we find that fibroblast growth factor 21 (FGF21) administration suppresses, and FGF21 deficiency worsens, retinal neovessel growth. The protective effect of FGF21 against neovessel growth was abolished in adiponectin (APN)-deficient mice. FGF21 administration also decreased neovascular lesions in two models of neovascular age-related macular degeneration: very-low-density lipoprotein-receptor-deficient mice with retinal angiomatous proliferation and laser-induced choroidal neovascularization...
February 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28160192/study-of-aqueous-cytokines-in-patients-with-different-patterns-of-diabetic-macular-edema-based-on-optical-coherence-tomography
#10
Sabyasachi Bandyopadhyay, Samir Kumar Bandyopadhyay, Mita Saha, Abhik Sinha
PURPOSE: To compare aqueous angiogenic and inflammatory cytokine concentrations in different patterns of diabetic macular edema (DME) based on optical coherence tomography (OCT). METHODS: This prospective study was conducted between July 1, 2015, and March 31, 2016, for 9 months. Aqueous samples were obtained from 52 consecutive DME patients and 16 controls. DME patients were divided according to OCT patterns into diffuse retinal thickening (DRT; n = 17), cystoid macular edema (CME; n = 20) and serous retinal detachment (SRD; n = 15) groups...
February 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28138697/niaspan-inhibits-diabetic-retinopathy%C3%A2-induced-vascular-inflammation-by-downregulating-the-tumor-necrosis-factor%C3%A2-%C3%AE-pathway
#11
Yang Wang, Xiangda Meng, Hua Yan
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes and a major cause of blindness in the developing world. Early DR is characterized by vascular neuroinflammation, cell apoptosis and breakdown of the blood‑retinal barrier (BRB). However, optimal treatment options and associated mechanisms remain unclear. Niaspan, which is widely used in the prevention and treatment of hyperlipidemia‑associated diseases, has been reported to inhibit inflammation. However, the effects of Niaspan and the mechanisms underlying the anti‑inflammatory effects of Niaspan on DR have yet to be reported...
January 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28114570/sustained-subconjunctival-delivery-of-infliximab-protects-the-cornea-and-retina-following-alkali-burn-to-the-eye
#12
Chengxin Zhou, Marie-Claude Robert, Vassiliki Kapoulea, Fengyang Lei, Anna M Stagner, Frederick A Jakobiec, Claes H Dohlman, Eleftherios I Paschalis
Purpose: Tumor necrosis factor (TNF)-α is upregulated in eyes following corneal alkali injury and contributes to corneal and also retinal damage. Prompt TNF-α inhibition by systemic infliximab ameliorates retinal damage and improves corneal wound healing. However, systemic administration of TNF-α inhibitors carries risk of significant complications, whereas topical eye-drop delivery is hindered by poor ocular bioavailability and the need for patient adherence. This study investigates the efficacy of subconjunctival delivery of TNF-α antibodies using a polymer-based drug delivery system (DDS)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28107073/choroidal-vasculopathy-and-retinal-detachment-in-a-bald-eagle-haliaeetus-leucocephalus-with-lead-toxicosis
#13
Ramzi Eid, David Sanchez-Migallon Guzman, Krista A Keller, K Tomo Wiggans, Christopher J Murphy, Elise E B LaDouceur, M Kevin Keel, Christopher M Reilly
A subadult male bald eagle ( Haliaeetus leucocephalus ) was presented for severe depression and weakness. Physical examination findings included depressed mentation, dehydration, sternal recumbency, poor body condition, and bilateral, whole-head, horizontal nystagmus. A heavy-metal panel was performed, and blood lead levels were 6.1 ppm. Treatment for lead poisoning was initiated, including subcutaneous fluids and parenteral calcium-disodium ethylenediaminetetraacetic acid, ceftiofur, and meloxicam. Ophthalmic examination findings included absent menace response, absent dazzle reflex, slow and incomplete direct pupillary light reflex, mild anterior uveitis, incipient cataracts, multifocal retinal tears, and retinal separation in both eyes...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28105976/early-subretinal-allograft-rejection-is-characterized-by-innate-immune-activity
#14
Kevin P Kennelly, Toby M Holmes, Deborah M Wallace, Cliona O'Farrelly, David J Keegan
<p>Successful subretinal transplantation is limited by considerable early graft loss, despite pharmacological suppression of adaptive immunity. We postulated that early innate immune activity is a dominant factor in determining graft survival and chose a non-immunosuppressed mouse model of retinal pigment epithelial (RPE) cell transplantation to explore this.</p><p>Expression of almost all measured cytokines by DH01 RPE cells increased significantly following graft preparation and the neutrophil chemoattractant, KC/GRO/CINC, was most significantly increased...
January 20, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28105484/-intravitreal-ganciclovir-as-an-additional-therapy-option-in-acute-retinal-necrosis
#15
M Bischoff-Jung, A Viestenz, M Fiorentzis, L Daas, B Seitz, G Pappas, A Viestenz
Acute retinal necrosis (ARN) is a rare viral inflammatory disease, characterized by uveitis, retinal vasculitis, and necrosis in the late stages. Therapeutic management is based on the clinical findings. The positive outcome in our patient (VA 0.6) indicates that, beside the management of retinal detachment and lens opacification, additional intravitreal injections of 2 mg ganciclovir may achieve better results than systemic/topical antiviral application alone.
January 19, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28100481/safety-of-anterior-chamber-paracentesis-using-a-30-gauge-needle-integrated-with-a-specially-designed-disposable-pipette
#16
Koji Kitazawa, Chie Sotozono, Noriko Koizumi, Kenji Nagata, Tsutomu Inatomi, Hiroshi Sasaki, Shigeru Kinoshita
AIMS: To investigate the safety of anterior chamber (AC) paracentesis using a 30-gauge needle integrated with a specially designed disposable pipette. METHODS: In this retrospective observational case-series study, AC paracentesis was performed on 301 eyes of 301 patients between September 2009 and August 2016 at the Department of Ophthalmology, Kyoto Prefectural University of Medicine and the Baptist Eye Institute, Kyoto, Japan. AC paracentesis was performed with the patient placed in the supine position using a 30-gauge needle integrated with a disposable pipette with one hand, and the safety post procedure was then evaluated...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28094044/diagnosis-and-treatment-of-acute-retinal-necrosis-a-report-by-the-american-academy-of-ophthalmology
#17
Scott D Schoenberger, Stephen J Kim, Jennifer E Thorne, Prithvi Mruthyunjaya, Steven Yeh, Sophie J Bakri, Justis P Ehlers
PURPOSE: To evaluate the available evidence in peer-reviewed publications about the diagnosis and treatment of acute retinal necrosis (ARN). METHODS: Literature searches of the PubMed and Cochrane Library databases were last conducted on July 27, 2016. The searches identified 216 unique citations, and 49 articles of possible clinical relevance were reviewed in full text. Of these 49 articles, 27 were deemed sufficiently relevant or of interest, and they were rated according to strength of evidence...
January 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28087150/apelin-protects-against-nmda-induced-retinal-neuronal-death-via-an-apj-receptor-by-activating-akt-and-erk1-2-and-suppressing-tnf-%C3%AE-expression-in-mice
#18
Yuki Ishimaru, Akihide Sumino, Daiki Kajioka, Fumiya Shibagaki, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda
Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intravitreal injection of NMDA in the retinas of mice. An intravitreal injection of NMDA induced neuronal cell death in both the retinal ganglion cell layer and inner nuclear layer, and reduced the amplitudes of scotopic threshold response (STR) in electroretinography studies...
December 24, 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28074262/activated-microglia-induce-the-production-of-reactive-oxygen-species-and-promote-apoptosis-of-co-cultured-retinal-microvascular-pericytes
#19
Xinyi Ding, Meng Zhang, Ruiping Gu, Gezhi Xu, Haixiang Wu
PURPOSE: Pericyte apoptosis is a predominant feature of early diabetic retinopathy. In diabetic retinopathy, activated microglia migrate and release proinflammatory cytokines that contribute to disruption of the blood-retinal barrier, neuronal loss, and enhanced ROS production. Reactive oxygen species (ROS) are implicated in pericyte death; however, the mechanism by which activated microglia affect retinal microvascular pericytes is unclear. We hypothesized that activated microglia may promote pericyte apoptosis by enhancing ROS production...
January 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28070752/absence-of-macrophage-migration-inhibitory-factor-reduces-proliferative-retinopathy-in-a-mouse-model
#20
Jing Wang, Jihong Lin, Ulrike Kaiser, Paulus Wohlfart, Hans-Peter Hammes
AIMS: Ischemia-induced neovascularization is the key feature of proliferative diabetic retinopathy. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory and proangiogenic cytokine, and its levels are elevated in the vitreous of patients with proliferative diabetic retinopathy. In this study, we aimed at investigating the relative potential of MIF in the ischemia-induced retinal neovascularization. METHODS: Both WT and MIF-knockout mice were subjected to the retinopathy of prematurity (ROP) model...
January 9, 2017: Acta Diabetologica
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