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https://www.readbyqxmd.com/read/29681857/a-synthesized-glucocorticoid-induced-leucine-zipper-peptide-inhibits-retinal-m%C3%A3-ller-cell-gliosis
#1
Ruiping Gu, Xinyi Ding, Wenyi Tang, Boya Lei, Chen Jiang, Gezhi Xu
Purpose: The anti-inflammatory activities of protein glucocorticoid-induced leucine zipper (GILZ) have been demonstrated in vivo and in vitro . Here, we examined the potential effect of a synthetic peptide derived from the leucine zipper motif and proline-rich region of GILZ on suppressing inflammatory responses in primary cultured rat Müller cells. Methods: Peptides were selected from amino acids 98-134 of the GILZ protein (GILZ-p). Solid-phase peptide synthesis was used to generate the cell-penetrating peptide TAT, which was bound to the amino terminus of GILZ-p...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29678603/chebulagic-acid-chebulinic-acid-and-gallic-acid-the-active-principles-of-triphala-inhibit-tnf%C3%AE-induced-pro-angiogenic-and-pro-inflammatory-activities-in-retinal-capillary-endothelial-cells-by-inhibiting-p38-erk-and-nfkb-phosphorylation
#2
Sivasankar Shanmuganathan, Narayanasamy Angayarkanni
Tumor necrosis factor-α (TNFα) a pleiotropic cytokine induces pro-inflammatory and pro-angiogenic changes in conditions such as diabetic retinopathy (DR) and neovascular age related macular degeneration (NV-AMD). Hence, inhibition of TNFα mediated changes can benefit the management of DR and NV-AMD. Triphala, an ayurvedic herbal preparation is known to have immunomodulatry functions. In this study we evaluated the alcoholic extract of triphala (AlE) and its compounds Chebulagic acid (CA), Chebulinic acid (CI) and Gallic acid (GA) for their anti-TNFα activity...
April 17, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29660509/glycosylation-enhanced-biocompatibility-of-the-supramolecular-hydrogel-of-an-anti-inflammatory-drug-for-topical-suppression-of-inflammation
#3
Taotao Xiong, Xianglian Li, Yanfang Zhou, Qianqian Song, Renshu Zhang, Lei Lei, Xingyi Li
Intravitreal/periocular injection of triamcinolone acetonide (TA) suspension is a common uveitis treatment, but it displays a high risk for serious side effects (e.g., high intraocular pressure, retinal toxicity). We report here an intravitreally injectable thermosensitive glycosylated TA (TA-SA-Glu) hydrogel, formed by covalently conjugating glucosamine (Glu) with succinate TA (TA-SA), for treating uveitis. The TA-SA-Glu hydrogelator forms a supramolecular hydrogel spontaneously in aqueous solution with a minimal gelation concentration of 0...
April 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29629640/full-thickness-macular-hole-without-necrosis-in-a-case-of-viral-retinitis
#4
Sangeeta Roy, Brijesh Takkar, Priyanka Khandelwal, Rohan Chawla
No abstract text is available yet for this article.
January 1, 2018: Tropical Doctor
https://www.readbyqxmd.com/read/29605771/the-dipeptidyl-peptidase-4-dpp-4-inhibitor-sitagliptin-ameliorates-retinal-endothelial-cell-dysfunction-triggered-by-inflammation
#5
Andreia Gonçalves, Luísa Almeida, Ana Paula Silva, Carlos Fontes-Ribeiro, António F Ambrósio, Armando Cristóvão, Rosa Fernandes
Diabetic retinopathy is considered a low-grade chronic inflammatory disease and several inflammatory molecules, including tumor necrosis factor (TNF)-α, are known to play a major role in the degeneration of retinal capillaries. Previous studies have reported that sitagliptin, a DPP-4 inhibitor, prevents the increase in blood-retinal barrier (BRB) permeability and inhibits the tight junction disassembly induced by diabetes. AIM: Our goal was to investigate whether sitagliptin is able to prevent retinal endothelial cells (EC) dysfunction triggered by the pro-inflammatory cytokine TNF-α...
March 29, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29582832/progressive-outer-retinal-necrosis-after-rituximab-and-cyclophosphamide-therapy
#6
Mohit Dogra, Priya Bajgai, Ashok Kumar, Aman Sharma
We report a case of progressive outer retinal necrosis (PORN) in a patient of microscopic polyangitis (MPA), being treated with immunosuppressive drugs such as cyclophosphamide and rituximab. Her aqueous tap was positive for Varicella Zoster virus and she was treated with oral and intravitreal antivirals, along with discontinuation of one of the immunosuppressive agents, i.e. rituximab, which might have led to reactivation of the virus causing necrotizing retinitis lesions. Rituximab and cyclophosphamide are extremely potent drugs, which are necessary to manage immunological disorders such as MPA...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29563125/sequential-retinal-necrosis-secondary-to-varicella-zoster-in-unrecognised-long-standing-hiv-infection-patient-safety-report
#7
Brigid Ky Ning, Simon P Kelly, Celia Chu, Emile Morgan
A retired woman with left ophthalmic shingles of over 2 years' duration attended with bilateral vision loss and systemic upset. Acute retinal necrosis with detachment was detected on right fundus examination. Cataract in left eye precluded funduscopy. Ocular ultrasonography revealed fibrotic retinal detachment in the left eye. MRI brain and orbits also showed signals of retinal detachment. No abnormal MRI signal within the optic nerve or brain was found. Varicella zoster virus was detected in ocular aqueous and blood samples...
March 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29548329/chronic-exposure-to-tumor-necrosis-factor-alpha-induces-retinal-pigment-epithelium-cell-dedifferentiation
#8
Sara Touhami, Fanny Beguier, Sébastien Augustin, Hugo Charles-Messance, Lucile Vignaud, Emeline F Nandrot, Sacha Reichman, Valérie Forster, Thibaud Mathis, José-Alain Sahel, Bahram Bodaghi, Xavier Guillonneau, Florian Sennlaub
BACKGROUND: The retinal pigment epithelium (RPE) is a monolayer of pigmented cells with important barrier and immuno-suppressive functions in the eye. We have previously shown that acute stimulation of RPE cells by tumor necrosis factor alpha (TNFα) downregulates the expression of OTX2 (Orthodenticle homeobox 2) and dependent RPE genes. We here investigated the long-term effects of TNFα on RPE cell morphology and key functions in vitro. METHODS: Primary porcine RPE cells were exposed to TNFα (at 0...
March 16, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29536169/-intraocular-inflammation-in-multiple-sclerosis
#9
N Stübiger, K Ruprecht, U Pleyer
Multiple sclerosis (MS) is a chronic inflammatory disorder of the brain and the spinal cord occurring mostly in young adults and is associated with temporary or permanent neurological deficits. An association between uveitis and MS has been recognized for a long time. Current data indicate an approximately 10 times higher prevalence of uveitis in patients with MS compared to the general population. In particular, MS is associated with intermediate uveitis and typically with concomitant retinal vasculitis...
March 13, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29528885/acute-retinal-necrosis-and-contralateral-cutaneous-eruption-after-the-shingles-vaccine
#10
Amro Ali, Malka Davina Kirschenbaum, Sansar Sharma, Thaddeus L Wandel
PURPOSE: To the best of our knowledge, we present a rare case report describing an occurrence of acute retinal necrosis in an otherwise healthy individual who received the shingles vaccine. METHODS: Observational case report. PATIENT: A 63-year-old healthy and immunocompetent white man presented with change of vision in the left eye after blunt trauma. A diagnosis of corneal abrasion was made. During follow-up, a detailed history discovered a progressive deterioration in vision over the past few weeks...
March 8, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29518884/-the-relationship-between-necroptosis-and-blinding-eye-diseases
#11
L L Xie, B Jiang
As a programmed cell death manner which is distinguished from apoptosis and autophagy, necroptosis is a newly discovered pathway of regulated necrosis that requires the protein receptor interacting protein kinases 1 and 3 and mixed lineage kinase domain-like protein. Necroptosis is mediated by death receptors, toll-like receptors and probably other mediators. Emerging evidences have delineated that necroptosis plays an important role in the occurrence and development of various blinding eye diseases. In this review, the related mechanism of necroptosis, the relationship between necroptosis and multiple blinding eye diseases, such as age-related macular degeneration, retinitis pigmentosa and glaucoma, and the potential therapeutic targets of necroptosis are discussed...
March 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29513760/metformin-suppresses-retinal-angiogenesis-and-inflammation-in-vitro-and-in-vivo
#12
Jing Han, Yue Li, Xiuli Liu, Tongrong Zhou, Haijing Sun, Paul Edwards, Hua Gao, Fu-Shin Yu, Xiaoxi Qiao
The oral anti-diabetic drug metformin has been found to reduce cardiovascular complications independent of glycemic control in diabetic patients. However, its role in diabetic retinal microvascular complications is not clear. This study is to investigate the effects of metformin on retinal vascular endothelium and its possible mechanisms, regarding two major pathogenic features of diabetic retinopathy: angiogenesis and inflammation. In human retinal vascular endothelial cell culture, metformin inhibited various steps of angiogenesis including endothelial cell proliferation, migration, and tube formation in a dose-dependent manner...
2018: PloS One
https://www.readbyqxmd.com/read/29480272/bilateral-central-retinal-artery-occlusion-as-presenting-manifestation-of-human-immunodeficiency-virus-infection
#13
Reema Bansal, Sahil Jain, Vishali Gupta, Aman Sharma, Amanjit Bal, Sanjay Jain
A 30-year-old male with bilateral acute visual loss presented with retinal edema in the posterior pole and peripapillary region with extensive retinal hemorrhages. Fluorescein angiography revealed delayed arterial filling in the right eye and absent arterial filling in the left eye, suggesting bilateral central retinal artery occlusion. Systemic evaluation revealed a history of chronic low-grade fever and generalized lymphadenopathy. HIV (ELISA) was positive, and other systemic comorbidities were ruled out...
March 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29455557/the-effects-of-rutin-on-cisplatin-induced-oxidative-retinal-and-optic-nerve-injury-an-experimental-study
#14
Nurdan Gamze Taşlı, Turgay Uçak, Yücel Karakurt, Ferda Keskin Çimen, Aslı Özbek Bilgin, Nezahat Kurt, Halis Süleyman
AIM: To determine the role of rutin in prevention of cisplatin induced retinal and optic nerve injury in an experimental study. MATERIAL AND METHODS: Totally 18 albino Wistar male rats were assigned into 3 groups, as follows: healthy controls (HC group), only cisplatin administered group for 14 days (CIS group), and Rutin + cisplatin administered group for 14 days (RC group). Blood samples were obtained from animals just before the scarification. Serum malondialdehyde (MDA), Myeloperoxidase (MPO), total glutathione (tGSH), Superoxide Dismutase (SOD), interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) levels were investigated...
February 19, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29452101/cytokine-signaling-protein-3-deficiency-in-myeloid-cells-promotes-retinal-degeneration-and-angiogenesis-through-arginase-1-up-regulation-in-experimental-autoimmune-uveoretinitis
#15
Mei Chen, Jiawu Zhao, Imran H A Ali, Stephen Marry, Josy Augustine, Mohajeet Bhuckory, Aisling Lynch, Adrien Kissenpfennig, Heping Xu
The suppressor of cytokine signaling protein 3 (SOCS3) critically controls immune cell activation, although its role in macrophage polarization and function remains controversial. Using experimental autoimmune uveoretinitis (EAU) as a model, we show that inflammation-mediated retinal degeneration is exaggerated and retinal angiogenesis is accelerated in mice with SOCS3 deficiency in myeloid cells (LysMCre/+ SOCS3fl/fl ). At the acute stage of EAU, the population of infiltrating neutrophils was increased and the population of macrophages decreased in LysMCre/+ SOCS3fl/fl mice compared with that in wild-type (WT) mice...
February 13, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29449964/consequences-of-inadvertent-intravitreal-mitomycin-c-injection
#16
Ahmad Mirshahi, Alireza Lashay, Mohammad Reza Mehrabi Bahar, Mojtaba Abrishami
Background: Mitomycin C (MMC) as an alkylating agent is miscellaneous an antineoplastic, antibiotic and ophthalmic agent. Here we aim to report a case of inadvertent intravitreal MMC injection instead of Avastin in case of diabetic macular edema. Case presentation: A 53 years old woman was planned to receive intravitreal Avastin injection, but accidentally, 0.05 ml of MMC 0.2% was injected. Best corrected visual acuity (BCVA) was 20/160 before injection. After 2 days, patient was referred to a tertiary referral eye center...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29447915/comparing-treatment-of-acute-retinal-necrosis-with-either-oral-valaciclovir-or-intravenous-aciclovir
#17
Julijana Baltinas, Sue Lightman, Oren Tomkins-Netzer
PURPOSE: To compare the visual outcomes of patients with acute retinal necrosis (ARN) treated initially with intravenous aciclovir versus oral valaciclovir therapy. DESIGN: Retrospective, comparative, interventional case series. METHODS: 62 patients (68 eyes) with ARN, treated at Moorfields Eye Hospital (United Kingdom) between 1992 and 2016, were identified through the hospital's electronic database. Exclusion criteria included insufficient patient records or follow-up (<150 days)...
February 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29425799/vancomycin-associated-hemorrhagic-occlusive-retinal-vasculitis-a-clinical-pathophysiological-analysis
#18
Bozho Todorich, Lisa J Faia, Aristomenis Thanos, Mitual Amin, Robert Folberg, Jeremy D Wolfe, Krista M Todorich, Efthemios Raphtis, Alan J Ruby, George A Williams, Tarek S Hassan
PURPOSE: To derive novel insights into the pathophysiology of vancomycin-related hemorrhagic occlusive retinal vasculopathy (HORV) through a careful clinicopathologic correlation. METHODS: and study design: We retrospectively reviewed the clinical and pathologic course of two consecutive patients who developed HORV. The clinical history, multimodal imaging, ultrasound biomicroscopy (UBM), intraoperative and histological findings are reported. RESULTS: Both patients presented with decreased vision and eye pain within 1 week following otherwise uncomplicated cataract extraction and were diagnosed with HORV after endophthalmitis was ruled out...
February 6, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29420113/risk-factors-for-development-of-rhegmatogenous-retinal-detachment-in-patients-with-uveitis
#19
Paradee Kunavisarut, Titipol Srisomboon, Direk Patikulsila, Janejit Choovuthayakorn, Nawat Watanachai, Voraporn Chaikitmongkol, Kessara Pathanapitoon, Aniki Rothova
PURPOSE: To describe risk factors for development of rhegmatogenous retinal detachment (RRD) in patients with uveitis. METHODS: We performed a retrospective review of 411 consecutive human immunodeficiency virus-negative patients with uveitis (571 affected eyes) and report on prevalence, risk factors and visual outcomes of patients with RRD. RESULTS: Prevalence of RRD was 7% of all patients with uveitis. Multivariate analysis revealed that posterior uveitis and panuveitis were associated with RRD (P = 0...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29414318/genes-related-to-cell-mediated-cytotoxicity-and-interferon-response-are-induced-in-the-retina-of-european-sea-bass-upon-intravitreal-infection-with-nodavirus
#20
Yulema Valero, Bassima Boughlala, Marta Arizcun, Sonal Patel, Ingrid U Fiksdal, M Ángeles Esteban, Joaquín De Juan, José Meseguer, Elena Chaves-Pozo, Alberto Cuesta
Viral diseases are responsible for high rates of mortality and subsequent economic losses in modern aquaculture. The nervous necrosis virus (NNV) produces viral encephalopathy and retinopathy (VER), which affects the central nervous system, is considered one of the most serious viral diseases in marine aquaculture. Although some studies have localized NNV in the retina cells, none has dealt with immunity in the retina. Thus, for the first time, we intravitreally infected healthy specimens of European sea bass (Dicentrarchus labrax) with NNV with the aim of characterizing the immune response in the retina...
February 2, 2018: Fish & Shellfish Immunology
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