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age related maculopathy

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https://www.readbyqxmd.com/read/27928964/hot-topics-in-pharmacogenetics-of-age-related-macular-degeneration
#1
Stephen G Schwartz, Milam A Brantley, Jaclyn L Kovach, Andrzej Grzybowski
Age-related macular degeneration (AMD) is a leading cause of irreversible visual loss and is primarily treated with nutritional supplementation as well as with anti-vascular endothelial growth factor (VEGF) agents for certain patients with neovascular disease. AMD is a complex disease with both genetic and environmental risk factors. In addition, treatment outcomes from nutritional supplementation and anti-VEGF agents vary considerably. Therefore, it is reasonable to suspect that there may be pharmacogenetic influences on these treatments...
December 8, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27893622/image-quality-and-artifacts-on-optical-coherence-tomography-angiography-comparison-of-pathologic-and-paired-fellow-eyes-in-65-patients-with-unilateral-choroidal-melanoma-treated-with-plaque-radiotherapy
#2
Emil A T Say, Sandor Ferenczy, George N Magrath, Wasim A Samara, Chloe T L Khoo, Carol L Shields
PURPOSE: To study image quality and artifacts seen on optical coherence tomography angiography (OCTA). METHODS: Sixty-five consecutive patients with unilateral posterior uveal melanoma treated with plaque radiotherapy had OCTA during follow-up. Optical coherence tomography angiography was performed on both the affected and fellow eye. Signal strength and frequency of image artifacts on en face images were compared between affected and fellow eyes. RESULTS: A total of 130 eyes in 65 patients were analyzed, the mean age at time of OCTA was 55 years (median: 56, range: 12-81 years), and 39 (39/65, 60%) were female...
November 23, 2016: Retina
https://www.readbyqxmd.com/read/27866147/benefits-potential-harms-and-optimal-use-of-nutritional-supplementation-for-preventing-progression-of-age-related-macular-degeneration
#3
REVIEW
Carlos H Rojas-Fernandez, Kevin Tyber
OBJECTIVE: To briefly review age-related macular degeneration (AMD), the main findings from the Age Related Eye Disease Study (AREDS) report number 8 on the use of nutritional supplements for AMD, and to focus on data suggesting that supplement use should be guided using genetic testing of AMD risk genes. DATA SOURCES: A literature search (January 2001 through October 26, 2016) was conducted using MEDLINE and the following MeSH terms: Antioxidants/therapeutic use, Genotype, Macular Degeneration/drug therapy, Macular degeneration/genetics, Dietary Supplements, Proteins/genetics, and Zinc Compounds/therapeutic use Bibliographies of publications identified were also reviewed...
November 19, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27847643/novel-perspectives-on-swept-source-optical-coherence-tomography
#4
REVIEW
Fabio Lavinsky, Daniel Lavinsky
Technologies for multimodal digital imaging of vitreoretinal diseases have improved the accuracy of diagnosis and the depth of the knowledge of the mechanisms of disease and their response to treatments. Optic coherence tomography (OCT) has become a mandatory tool for the management and for the follow-up of retinal pathologies. OCT technology evolved in the last two decades from time-domain to spectral domain and recently to the swept-source OCTs (SS-OCT). SS-OCT improved the depth of imaging and the scan speed, thus adding novel algorithms and features such as for vitreous and vitreoretinal interface evaluation, choroid segmentation and mapping, OCT angiography and En-face OCT...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27825655/mediterranean-diet-score-and-its-association-with-age-related-macular-degeneration-the-european-eye-study
#5
Ruth E Hogg, Jayne V Woodside, Alanna McGrath, Ian S Young, Jesus L Vioque, Usha Chakravarthy, Paulus T de Jong, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Astrid E Fletcher
PURPOSE: To examine associations between adherence to a Mediterranean diet and prevalence of age-related macular degeneration (AMD) in countries ranging from Southern to Northern Europe. DESIGN: Cross-sectional, population-based epidemiologic study. PARTICIPANTS: Of 5060 randomly sampled people aged 65 years or older from 7 study centers across Europe (Norway, Estonia, United Kingdom, France, Italy, Greece, and Spain), full dietary data were available in 4753...
November 5, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27771146/heritability-of-choroidal-thickness-in-the-amish
#6
Rebecca J Sardell, Muneeswar G Nittala, Larry D Adams, Reneé A Laux, Jessica N Cooke Bailey, Denise Fuzzell, Sarada Fuzzell, Lori Reinhart-Mercer, Laura J Caywood, Violet Horst, Tine Mackay, Debbie Dana, SriniVas R Sadda, William K Scott, Dwight Stambolian, Jonathan L Haines, Margaret A Pericak-Vance
PURPOSE: To evaluate the heritability of choroidal thickness and its relationship to age-related macular degeneration (AMD). DESIGN: Cohort study. PARTICIPANTS: Six hundred eighty-nine individuals from Amish families with early or intermediate AMD. METHODS: Ocular coherence tomography was used to quantify choroidal thickness, and fundus photography was used to classify eyes into categories using a modified Clinical Age-Related Maculopathy Staging (CARMS) system...
December 2016: Ophthalmology
https://www.readbyqxmd.com/read/27769330/discrepancies-in-physician-patient-agreement-in-reporting-ocular-history
#7
Marko Popovic, Varun Chaudhary, Bryon R McKay, Prima Moinul, Mohammad Mohaghagh, Anne Beattie, Mark Fava, Dalia Eino, Keith Mann, Lawrence Kobetz, Joshua Barbosa
OBJECTIVE: The purpose of this study was to investigate the extent of agreement between physicians and patients in reporting ocular history and to determine whether there are any predictive factors for physician-patient consensus. DESIGN: Retrospective chart review. PARTICIPANTS: Between June and September 2014, adult patients undergoing cataract surgery were recruited for the study. METHODS: Before surgery, patient demographics and self-reported ocular history were extracted from a prospectively collected database...
October 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27605007/proteomics-based-identification-and-validation-of-novel-plasma-biomarkers-phospholipid-transfer-protein-and-mannan-binding-lectin-serine-protease-1-in-age-related-macular-degeneration
#8
Hye-Jung Kim, Seong Joon Ahn, Se Joon Woo, Hye Kyoung Hong, Eui Jin Suh, Jeeyun Ahn, Ji Hyun Park, Na-Kyung Ryoo, Ji Eun Lee, Ki Woong Kim, Kyu Hyung Park, Cheolju Lee
Age-related macular degeneration (AMD) is a major cause of severe, progressive visual loss among the elderly. There are currently no established serological markers for the diagnosis of AMD. In this study, we carried out a large-scale quantitative proteomics analysis to identify plasma proteins that could serve as potential AMD biomarkers. We found that the plasma levels of phospholipid transfer protein (PLTP) and mannan-binding lectin serine protease (MASP)-1 were increased in AMD patients relative to controls...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27601870/clinical-presentation-and-visual-status-of-retinitis-pigmentosa-patients-a-multicenter-study-in-southwestern-nigeria
#9
Oluwatoyin Helen Onakpoya, Caroline Olufunlayo Adeoti, Tunji Sunday Oluleye, Iyiade Adeseye Ajayi, Timothy Majengbasan, Olayemi Kolawole Olorundare
BACKGROUND: To review the visual status and clinical presentation of patients with retinitis pigmentosa (RP). METHODOLOGY: Multicenter, retrospective, and analytical review was conducted of the visual status and clinical characteristics of patients with RP at first presentation from January 2007 to December 2011. Main outcome measure was the World Health Organization's visual status classification in relation to sex and age at presentation. Data analysis by SPSS (version 15) and statistical significance was assumed at P<0...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27596850/investigation-of-precursor-lesions-of-polypoidal-choroidal-vasculopathy-using-contralateral-eye-findings
#10
Se Woong Kang, Hoyoung Lee, Kunho Bae, Joo Young Shin, Sang Jin Kim, Jong Min Kim
PURPOSE: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). METHODS: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs)...
September 5, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27560847/atypical-presentation-of-chorioretinal-folds-related-maculopathy
#11
Federico Corvi, Vittorio Capuano, Lucia Benatti, Francesco Bandello, Eric Souied, Giuseppe Querques
PURPOSE: Chorioretinal folds are undulations that anatomically include the inner choroid, Bruch's membrane, and the retinal pigment epithelium, and secondarily affect the overlying neurosensory retina. We analyzed clinical data and management of six patients diagnosed with chorioretinal folds-related maculopathy with atypical presentations. CASE REPORT: The mean age of the six patients (five women) was 77 years. Best-corrected visual acuity (BCVA) ranged between 20/200 and 20/80...
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27548038/retinal-vein-occlusion-in-a-patient-with-maternally-inherited-diabetes-and-deafness
#12
Christian J Sanfilippo, Pradeep Prasad, David Sarraf
PURPOSE: To report a case of maternally inherited diabetes and deafness complicated by branch retinal vein occlusion and cystoid macular edema. METHODS: Retrospective case report. Multimodal imaging including spectral domain optical coherence tomography, en face optical coherence tomography, and fundus autofluorescence was preformed, and the findings are presented. FINDINGS: A 58-year-old female with a history of diabetes mellitus, hearing loss, and a previous diagnosis of age-related macular degeneration presented with decreased vision in the right eye...
August 19, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27500671/a-phenotyping-regimen-for-genetically-modified-mice-used-to-study-genes-implicated-in-human-diseases-of-aging
#13
Victoria L Patterson, Brian S Thompson, Catherine Cherry, Shao-Bin Wang, Bo Chen, Josephine Hoh
Age-related diseases are becoming increasingly prevalent and the burden continues to grow as our population ages. Effective treatments are necessary to lessen the impact of debilitating conditions but remain elusive in many cases. Only by understanding the causes and pathology of diseases associated with aging, can scientists begin to identify potential therapeutic targets and develop strategies for intervention. The most common age-related conditions are neurodegenerative disorders such as Parkinson's disease and blindness...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27471039/response-to-areds-supplements-according-to-genetic-factors-survival-analysis-approach-using-the-eye-as-the-unit-of-analysis
#14
Johanna M Seddon, Rachel E Silver, Bernard Rosner
BACKGROUND/AIMS: The Age-Related Eye Disease Study (AREDS) reported the beneficial impact of antioxidant and zinc supplements on the risk of progression to advanced stages of age-related macular degeneration (AMD). We evaluated the role of genetic variants in modifying the relationship between supplementation and progression to advanced AMD. METHODS: Among 4124 eyes (2317 subjects with a genetic specimen), 882 progressed from no AMD, early or intermediate AMD to overall advanced disease, including geographic atrophy (GA) and neovascular disease (NV) over the course of the clinical trial...
December 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27445455/genetics-and-age-related-macular-degeneration-a-practical-review-for-the-clinician
#15
REVIEW
Stephen G Schwartz, Blake M Hampton, Jaclyn L Kovach, Milam A Brantley
Age-related macular degeneration is a complex disease, with both genetic and environmental risk factors interacting in unknown ways. Currently, 52 gene variants within 34 loci have been significantly associated with age-related macular degeneration. Two well-studied major genes are complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). There exist several commercially available tests that are proposed to stratify patients into high-risk and low-risk groups, as well as predict response to nutritional supplementation...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27435576/effects-of-topical-atropine-on-intraocular-pressure-and-myopia-progression-a-prospective-comparative-study
#16
Chia-Yi Lee, Chi-Chin Sun, Yi-Fang Lin, Ken-Kuo Lin
BACKGROUND: Myopia-related maculopathy is one of the leading causes of blindness in the world. The prevalence of myopia has been reported as high as 90 % in some Asian countries. Therefore, controlling myopia progression is an urgent public issue. The purpose of this study is to evaluate the effects of topical atropine with different concentrations on intraocular pressure measurements and myopia progression in school-aged children in Taiwan. METHODS: Fifty-six myopic children were divided into three groups: 32 children were treated with 0...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27430579/intra-and-inter-rater-agreement-between-an-ophthalmologist-and-mid-level-ophthalmic-personnel-to-diagnose-retinal-diseases-based-on-fundus-photographs-at-a-primary-eye-center-in-nepal-the-bhaktapur-retina-study
#17
Raba Thapa, Sanyam Bajimaya, Renske Bouman, Govinda Paudyal, Shankar Khanal, Stevie Tan, Suman S Thapa, Ger van Rens
BACKGROUND: Early detection can reduce irreversible blindness from retinal diseases. This study aims to assess the intra- and inter-rater agreement of retinal pathologies observed on fundus photographs between an ophthalmologist and two-mid level ophthalmic personnel (MLOPs). METHOD: A population-based, cross-sectional study was conducted among subjects 60 years and above in the Bhaktapur district of Nepal. Fundus photographs of 500 eyes of 500 subjects were assessed...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27380223/incidence-of-acute-exudative-maculopathy-after-reduced-fluence-photodynamic-therapy
#18
Zaid Mammo, Farzin Forooghian
PURPOSE: To describe the incidence and features of acute exudative maculopathy (AEM) after half-fluence photodynamic therapy (PDT) and/or very minimal fluence PDT. METHODS: Retrospective chart review of all patients treated over a 7-year period. RESULTS: A total of 52 patients (58 eyes, 140 treatments) were treated with half-fluence PDT and/or very minimal fluence PDT. Patients were diagnosed with either central serous chorioretinopathy (CSCR) or neovascular age-related macular degeneration (nAMD)...
July 1, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27270414/the-unconventional-secretion-of-arms2
#19
Elod Kortvely, Stefanie M Hauck, Jennifer Behler, Nurulain Ho, Marius Ueffing
Age-related maculopathy susceptibility 2 (ARMS2) is a small (11 kDa), primate-specific protein found in the extracellular matrix of the choroid layer in the eye. Variants in the corresponding genetic locus are highly associated with age-related macular degeneration (AMD), a leading cause of blindness in the elderly. So far, the physiological function of ARMS2 has remained enigmatic. It has been demonstrated that ARMS2 is a genuine secreted protein devoid of an N-terminal leader sequence, yet the mechanism how it exits the cells and enters the choroidal matrix is not understood...
June 6, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27269047/association-of-combined-complement-factor-h-y402h-and-arms-loc387715-a69s-polymorphisms-with-age-related-macular-degeneration-a-meta-analysis
#20
Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Mortaza Bonyadi, Masoud Soheilian, Saeed Karimi
PURPOSE: Complement factor H (CFH) Y402H (rs1061170) and age-related maculopathy susceptibility2 (ARMS2)/LOC387715 A69S (rs10490924) polymorphisms shown to have significant association with age-related macular degeneration (AMD). In this meta-analysis, we pooled the results of the available association studies between combined ARMS2/LOC387715A69S-CFHY402H genotypes and AMD to estimate the possible synergistic or multiplicative effects. METHODS: Heterogeneity of studies was evaluated using the Cochran Q-test and the I-square index...
June 7, 2016: Current Eye Research
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