Read by QxMD icon Read

age related maculopathy

Rebecca J Sardell, Muneeswar G Nittala, Larry D Adams, Reneé A Laux, Jessica N Cooke Bailey, Denise Fuzzell, Sarada Fuzzell, Lori Reinhart-Mercer, Laura J Caywood, Violet Horst, Tine Mackay, Debbie Dana, SriniVas R Sadda, William K Scott, Dwight Stambolian, Jonathan L Haines, Margaret A Pericak-Vance
PURPOSE: To evaluate the heritability of choroidal thickness and its relationship to age-related macular degeneration (AMD). DESIGN: Cohort study. PARTICIPANTS: Six hundred eighty-nine individuals from Amish families with early or intermediate AMD. METHODS: Ocular coherence tomography was used to quantify choroidal thickness, and fundus photography was used to classify eyes into categories using a modified Clinical Age-Related Maculopathy Staging (CARMS) system...
October 19, 2016: Ophthalmology
Marko Popovic, Varun Chaudhary, Bryon R McKay, Prima Moinul, Mohammad Mohaghagh, Anne Beattie, Mark Fava, Dalia Eino, Keith Mann, Lawrence Kobetz, Joshua Barbosa
OBJECTIVE: The purpose of this study was to investigate the extent of agreement between physicians and patients in reporting ocular history and to determine whether there are any predictive factors for physician-patient consensus. DESIGN: Retrospective chart review. PARTICIPANTS: Between June and September 2014, adult patients undergoing cataract surgery were recruited for the study. METHODS: Before surgery, patient demographics and self-reported ocular history were extracted from a prospectively collected database...
October 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Hye-Jung Kim, Seong Joon Ahn, Se Joon Woo, Hye Kyoung Hong, Eui Jin Suh, Jeeyun Ahn, Ji Hyun Park, Na-Kyung Ryoo, Ji Eun Lee, Ki Woong Kim, Kyu Hyung Park, Cheolju Lee
Age-related macular degeneration (AMD) is a major cause of severe, progressive visual loss among the elderly. There are currently no established serological markers for the diagnosis of AMD. In this study, we carried out a large-scale quantitative proteomics analysis to identify plasma proteins that could serve as potential AMD biomarkers. We found that the plasma levels of phospholipid transfer protein (PLTP) and mannan-binding lectin serine protease (MASP)-1 were increased in AMD patients relative to controls...
2016: Scientific Reports
Oluwatoyin Helen Onakpoya, Caroline Olufunlayo Adeoti, Tunji Sunday Oluleye, Iyiade Adeseye Ajayi, Timothy Majengbasan, Olayemi Kolawole Olorundare
BACKGROUND: To review the visual status and clinical presentation of patients with retinitis pigmentosa (RP). METHODOLOGY: Multicenter, retrospective, and analytical review was conducted of the visual status and clinical characteristics of patients with RP at first presentation from January 2007 to December 2011. Main outcome measure was the World Health Organization's visual status classification in relation to sex and age at presentation. Data analysis by SPSS (version 15) and statistical significance was assumed at P<0...
2016: Clinical Ophthalmology
Se Woong Kang, Hoyoung Lee, Kunho Bae, Joo Young Shin, Sang Jin Kim, Jong Min Kim
PURPOSE: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). METHODS: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs)...
September 5, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Federico Corvi, Vittorio Capuano, Lucia Benatti, Francesco Bandello, Eric Souied, Giuseppe Querques
PURPOSE: Chorioretinal folds are undulations that anatomically include the inner choroid, Bruch's membrane, and the retinal pigment epithelium, and secondarily affect the overlying neurosensory retina. We analyzed clinical data and management of six patients diagnosed with chorioretinal folds-related maculopathy with atypical presentations. CASE REPORT: The mean age of the six patients (five women) was 77 years. Best-corrected visual acuity (BCVA) ranged between 20/200 and 20/80...
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Christian J Sanfilippo, Pradeep Prasad, David Sarraf
PURPOSE: To report a case of maternally inherited diabetes and deafness complicated by branch retinal vein occlusion and cystoid macular edema. METHODS: Retrospective case report. Multimodal imaging including spectral domain optical coherence tomography, en face optical coherence tomography, and fundus autofluorescence was preformed, and the findings are presented. FINDINGS: A 58-year-old female with a history of diabetes mellitus, hearing loss, and a previous diagnosis of age-related macular degeneration presented with decreased vision in the right eye...
August 19, 2016: Retinal Cases & Brief Reports
Victoria L Patterson, Brian S Thompson, Catherine Cherry, Shao-Bin Wang, Bo Chen, Josephine Hoh
Age-related diseases are becoming increasingly prevalent and the burden continues to grow as our population ages. Effective treatments are necessary to lessen the impact of debilitating conditions but remain elusive in many cases. Only by understanding the causes and pathology of diseases associated with aging, can scientists begin to identify potential therapeutic targets and develop strategies for intervention. The most common age-related conditions are neurodegenerative disorders such as Parkinson's disease and blindness...
2016: Journal of Visualized Experiments: JoVE
Johanna M Seddon, Rachel E Silver, Bernard Rosner
BACKGROUND/AIMS: The Age-Related Eye Disease Study (AREDS) reported the beneficial impact of antioxidant and zinc supplements on the risk of progression to advanced stages of age-related macular degeneration (AMD). We evaluated the role of genetic variants in modifying the relationship between supplementation and progression to advanced AMD. METHODS: Among 4124 eyes (2317 subjects with a genetic specimen), 882 progressed from no AMD, early or intermediate AMD to overall advanced disease, including geographic atrophy (GA) and neovascular disease (NV) over the course of the clinical trial...
July 28, 2016: British Journal of Ophthalmology
Stephen G Schwartz, Blake M Hampton, Jaclyn L Kovach, Milam A Brantley
Age-related macular degeneration is a complex disease, with both genetic and environmental risk factors interacting in unknown ways. Currently, 52 gene variants within 34 loci have been significantly associated with age-related macular degeneration. Two well-studied major genes are complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). There exist several commercially available tests that are proposed to stratify patients into high-risk and low-risk groups, as well as predict response to nutritional supplementation...
2016: Clinical Ophthalmology
Chia-Yi Lee, Chi-Chin Sun, Yi-Fang Lin, Ken-Kuo Lin
BACKGROUND: Myopia-related maculopathy is one of the leading causes of blindness in the world. The prevalence of myopia has been reported as high as 90 % in some Asian countries. Therefore, controlling myopia progression is an urgent public issue. The purpose of this study is to evaluate the effects of topical atropine with different concentrations on intraocular pressure measurements and myopia progression in school-aged children in Taiwan. METHODS: Fifty-six myopic children were divided into three groups: 32 children were treated with 0...
2016: BMC Ophthalmology
Raba Thapa, Sanyam Bajimaya, Renske Bouman, Govinda Paudyal, Shankar Khanal, Stevie Tan, Suman S Thapa, Ger van Rens
BACKGROUND: Early detection can reduce irreversible blindness from retinal diseases. This study aims to assess the intra- and inter-rater agreement of retinal pathologies observed on fundus photographs between an ophthalmologist and two-mid level ophthalmic personnel (MLOPs). METHOD: A population-based, cross-sectional study was conducted among subjects 60 years and above in the Bhaktapur district of Nepal. Fundus photographs of 500 eyes of 500 subjects were assessed...
2016: BMC Ophthalmology
Zaid Mammo, Farzin Forooghian
PURPOSE: To describe the incidence and features of acute exudative maculopathy (AEM) after half-fluence photodynamic therapy (PDT) and/or very minimal fluence PDT. METHODS: Retrospective chart review of all patients treated over a 7-year period. RESULTS: A total of 52 patients (58 eyes, 140 treatments) were treated with half-fluence PDT and/or very minimal fluence PDT. Patients were diagnosed with either central serous chorioretinopathy (CSCR) or neovascular age-related macular degeneration (nAMD)...
July 1, 2016: Retinal Cases & Brief Reports
Elod Kortvely, Stefanie M Hauck, Jennifer Behler, Nurulain Ho, Marius Ueffing
Age-related maculopathy susceptibility 2 (ARMS2) is a small (11 kDa), primate-specific protein found in the extracellular matrix of the choroid layer in the eye. Variants in the corresponding genetic locus are highly associated with age-related macular degeneration (AMD), a leading cause of blindness in the elderly. So far, the physiological function of ARMS2 has remained enigmatic. It has been demonstrated that ARMS2 is a genuine secreted protein devoid of an N-terminal leader sequence, yet the mechanism how it exits the cells and enters the choroidal matrix is not understood...
June 6, 2016: Human Molecular Genetics
Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Mortaza Bonyadi, Masoud Soheilian, Saeed Karimi
PURPOSE: Complement factor H (CFH) Y402H (rs1061170) and age-related maculopathy susceptibility2 (ARMS2)/LOC387715 A69S (rs10490924) polymorphisms shown to have significant association with age-related macular degeneration (AMD). In this meta-analysis, we pooled the results of the available association studies between combined ARMS2/LOC387715A69S-CFHY402H genotypes and AMD to estimate the possible synergistic or multiplicative effects. METHODS: Heterogeneity of studies was evaluated using the Cochran Q-test and the I-square index...
June 7, 2016: Current Eye Research
Nicole T M Saksens, Yara T E Lechanteur, Sanne K Verbakel, Joannes M M Groenewoud, Mohamed R Daha, Tina Schick, Sascha Fauser, Camiel J F Boon, Carel B Hoyng, Anneke I den Hollander
AIMS: Age-related macular degeneration (AMD) is a multifactorial disease, in which complement-mediated inflammation plays a pivotal role. A positive family history is an important risk factor for developing AMD. Certain lifestyle factors are shown to be significantly associated with AMD in non-familial cases, but not in familial cases. This study aimed to investigate whether the contribution of common genetic variants and complement activation levels differs between familial and sporadic cases with AMD...
2016: PloS One
Miguel A Zapata, Gabriel Arcos, Alex Fonollosa, Maximino Abraldes, Andrea Oleñik, Estanislao Gutierrez, Jose Garcia-Arumi
PURPOSE: Describe the first 3 years of highly specialized retinal screening through a web platform using a retinologists' network for image reading. METHODS: All patients who came to centers in the network and consented to fundus photography were included. Images were evaluated by ophthalmologists. We describe number of patients, age, visual acuity, retinal abnormalities, medical recommendations, and factors associated with abnormal retinographies. RESULTS: Fifty thousand three hundred eighty-four patients were included; mean age 52...
May 26, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Nagahisa Yoshimura
Age-related macular degeneration (AMD) in the Japanese often shows different clinical features from those described in Caucasians. For example, we often observe choroidal neovascularization (CNV) in elderly patients without drusen in the fundus. The high incidence of polypoidal choroidal vasculopathy (PCV) in AMD among Japanese is well-known. The reason why such differences occur in clinical manifestations of AMD has been one of my main interests. In this review article, I will discuss the characteristics of AMD in the Japanese population, as found in our recent study...
March 2016: Nippon Ganka Gakkai Zasshi
Jost B Jonas, Liang Xu, Ya Xing Wang, Hong Sheng Bi, Jian Feng Wu, Wen Jun Jiang, Vinay Nangia, Ajit Sinha, Dan Zhu, Yong Tao, Yin Guo, Qi Sheng You, Li Juan Wu, Li Xin Tao, Xiu Hua Guo, Kyoko Ohno-Matsui, Songhomitra Panda-Jonas
PURPOSE: Since high myopia in the younger generation may differ etiologically from high myopia in older generations, we examined whether education-related parameters differ between high myopia in today´s school children and high pathological myopia in today´s elderly generation. METHODS: The investigation included the adult populations of the population-based Beijing Eye Study (BES) (3468 adults;mean age:64.6±9.8years;range:50-93years) and Central India Eye and Medical Study (CIEMS) (4711 adults;age:49...
2016: PloS One
Samuel G Jacobson, Rodrigo Matsui, Alexander Sumaroka, Artur V Cideciyan
PURPOSE: We reviewed and illustrated the most optimal retinal structural measurements to make in stem cell clinical trials. METHODS: Optical coherence tomography (OCT) and autofluorescence (AF) imaging were used to evaluate patients with severe visual loss from nonsyndromic and syndromic retinitis pigmentosa (RP), ABCA4-Stargardt disease, and nonneovascular age-related macular degeneration (AMD). Outer nuclear layer (ONL), rod outer segment (ROS) layer, inner retina, ganglion cell layer (GCL), and nerve fiber layer (NFL) thicknesses were quantified...
April 1, 2016: Investigative Ophthalmology & Visual Science
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"