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age related maculopathy

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https://www.readbyqxmd.com/read/29858676/subjective-evaluation-of-visual-acuity-is-not-reliable-to-detect-disease-activity-in-different-exudative-maculopathies
#1
Marie-Christine Bruender, Nicola Benjamin, Hansjuergen Thomas Agostini, Andreas Stahl, Christoph Ehlken
BACKGROUND: Patients with exudative maculopathies (neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO)) are faced with a high burden of examinations and treatments. This study was conceived to analyze the accuracy of a subjective evaluation of visual acuity (VA) and metamorphopsia to detect disease reactivation, compared to morphological signs of reactivation assessed by means of SD-OCT. METHODS: Retrospective study of 888 patients treated for nAMD (n = 638), DME (84), BRVO (110), and CRVO (56) was conducted...
June 1, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29801032/association-of-single-nucleotide-polymorphisms-in-age-related-macular-degeneration-with-pseudodrusen-secondary-analysis-of-data-from-the-comparison-of-amd-treatments-trials
#2
Lisa Y Lin, Qiang Zhou, Stephanie Hagstrom, Maureen G Maguire, Ebenezer Daniel, Juan E Grunwald, Daniel F Martin, Gui-Shuang Ying
Importance: Previous studies investigating the association of single-nucleotide polymorphisms (SNPs) that confer increased risk of age-related macular degeneration (AMD) with pseudodrusen have yielded conflicting results and have not evaluated other AMD SNPs or pseudodrusen subtypes. Objective: To determine the association of SNPs in the complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2), HtrA serine peptidase 1 (HTRA1), complement C2 (C2), complement C3 (C3), lipase C (LIPC), and complement factor B (CFB) genes with the presence of pseudodrusen and pseudodrusen subtypes (ie, dot, reticular, and confluent)...
May 3, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29717154/dietary-environmental-and-genetic-risk-factors-of-extensive-macular-atrophy-with-pseudodrusen-a-severe-bilateral-macular-atrophy-of-middle-aged-patients
#3
Aymeric Douillard, Marie-Christine Picot, Cécile Delcourt, Sabine Defoort-Dhellemmes, Nour Al-Dain Marzouka, Annie Lacroux, Xavier Zanlonghi, Isabelle Drumare, Elsa Jozefowicz, Béatrice Bocquet, Corinne Baudoin, Sarah Perez-Roustit, Sophie Arsène, Valérie Gissot, François Devin, Carl Arndt, Benjamin Wolff, Martine Mauget-Faÿsse, Maddalena Quaranta, Thibault Mura, Dominique Deplanque, Hassiba Oubraham, Salomon Yves Cohen, Pierre Gastaud, Olivia Zambrowski, Catherine Creuzot-Garcher, Saddek Mohand Saïd, José-Alain Sahel, Eric Souied, Solange Milazzo, Rocio Blanco Garavito, Vasiliki Kalatzis, Bernard Puech, Christian Hamel, Isabelle Audo, Isabelle Meunier
EMAP (Extensive Macular Atrophy with Pseudodrusen) is a maculopathy we recently described that shares pseudodrusen and geographic atrophy with Age-related Macular Disease (AMD). EMAP differs from AMD by an earlier age of onset (50-55 years) and a characteristic natural history comprising a night blindness followed by a severe visual loss. In a prospective case-control study, ten referral centers included 115 EMAP (70 women, 45 men) patients and 345 matched controls to appraise dietary, environmental, and genetic risk factors...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29703285/outcomes-of-cataract-surgery-in-eyes-with-ocular-melanoma-treated-with-iodine-125-brachytherapy
#4
Tahir Kansu Bozkurt, Qiongyan Tang, Lev L Grunstein, Tara A McCannel, Bradley R Straatsma, Kevin M Miller
PURPOSE: To evaluate visual and surgical outcomes of cataract surgery in eyes with a history of iodine-125 (I125 ) brachytherapy for ocular melanoma. SETTING: Department of Ophthalmology, David Geffen School of Medicine at UCLA and the Stein Eye Institute, Los Angeles, California, USA. DESIGN: Retrospective case series. METHODS: Patients with ocular melanoma treated by I125 brachytherapy who subsequently had cataract surgery were evaluated...
March 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29554812/clinical-applications-of-optical-coherence-tomography-angiography-what-we-have-learnt-in-the-first-3-years
#5
Salomon Y Cohen, Alexandra Miere, Sylvia Nghiem-Buffet, Franck Fajnkuchen, Eric H Souied, Sarah Mrejen
A review of the literature from 2014 to 2016 was conducted, focusing on the results of optical coherence tomography angiography in different chorioretinal diseases. In only 3 years, optical coherence tomography angiography has been shown to be an effective tool for diagnosing choroidal neovascularization complicating age-related macular degeneration, pathologic myopia, and inflammatory conditions. The technique has sometimes been considered superior to conventional multimodal imaging, for example, in choroidal neovascularization associated with chronic central serous chorioretinopathy or multifocal choroiditis...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29533284/posterior-fundus-hemorrhages-frequency-and-associated-factors-the-beijing-eye-study
#6
Jin Qiong Zhou, Ya Xing Wang, Liang Xu, Liang Zhao, Shuang Wang, Jie Xu, Qi Sheng You, Hua Yang, Wen Bin Wei, Jost B Jonas
PURPOSE: To examine frequency and associations of retinal hemorrhages. METHODS: The population-based Beijing Eye Study included 3,468 individuals. Monoscopic fundus photographs were examined for hemorrhages. RESULTS: Retinal hemorrhages were detected in 515 eyes (429 individuals) (prevalence: 7.6%; 95% confidence interval [CI]: 7.0-8.0 per eye; 12.7%; 95% CI: 11.7-13.7 per person). Higher prevalence of retinal hemorrhages was correlated (multivariate analysis) with higher systolic blood pressure (P < 0...
March 12, 2018: Retina
https://www.readbyqxmd.com/read/29453225/prevalence-of-age-related-macular-degeneration-associated-genetic-risk-factors-and-4-year-progression-data-in-the-irish-population
#7
Emma Connolly, Maedbh Rhatigan, Aisling M O'Halloran, Katherine Alyson Muldrew, Usha Chakravarthy, Mark Cahill, Rose Anne Kenny, Sarah L Doyle
BACKGROUND/AIMS: Age-related macular degeneration (AMD) is estimated to affect 196 million people >50 years old globally. Prevalence of AMD-associated genetic risk factors and rate of disease progression are unknown in Ireland. METHODS: Prevalence of AMD-associated genetic risk variants, complement factor H (CFH) rs1061170, age-related maculopathy susceptibility 2 (ARMS2) rs10490924, component 3 (C3) rs2230199, complement factor B (CFB) rs641153 and superkiller viralicidic activity 2-like (SKIV2L) rs429608 and 4-year progression data in a population-representative cohort (The Irish Longitudinal study on Ageing (TILDA)) were assessed...
February 16, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29401182/association-between-contrast-sensitivity-and-reading-with-macular-pathology
#8
Tamara Brussee, Thomas J T P van den Berg, Ruth M A van Nispen, Ilon de Boer, Ger H M B van Rens
SIGNIFICANCE: Comparison between the role of spatial and temporal contrast sensitivities in the association with reading may provide insight into how visual tasks (such as reading) are related to primary optical or neural (or both) effects. More insight into primary visual factors influencing reading is important for understanding reading problems. PURPOSE: The aim of this study was to gain insight into the association between optical and neural components of contrast sensitivity (CS), operationalized as spatial CS (optical and neural) or temporal CS (solely neural), and reading speed in a clinical sample of participants with macular pathologies...
March 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29371011/progression-of-myopic-maculopathy-during-18-year-follow-up
#9
Yuxin Fang, Tae Yokoi, Natsuko Nagaoka, Kosei Shinohara, Yuka Onishi, Tomoka Ishida, Takeshi Yoshida, Xian Xu, Jost B Jonas, Kyoko Ohno-Matsui
PURPOSE: To examine the progression pattern of myopic maculopathy. DESIGN: Retrospective, observational case series. PARTICIPANTS: Highly myopic patients who had been followed up for 10 years or more. METHODS: Using fundus photographs, myopic features were differentiated according to Meta-analysis of Pathologic Myopia (META-PM) Study Group recommendations. MAIN OUTCOME MEASURES: Progression pattern of maculopathy...
June 2018: Ophthalmology
https://www.readbyqxmd.com/read/29316486/exploring-the-association-of-rs10490924-polymorphism-with-age-related-macular-degeneration-an-in-silico-approach
#10
Farhad Jahanfar, Hamed Hamishehkar
The polymorphism rs10490924 (A69S) in the age-related maculopathy susceptibility 2 (ARMS2) gene is highly associated with age-related macular degeneration, which is the leading cause of blindness among the elderly population. ARMS2 gene encodes a putative small (11 kDa) protein, which the function and localization of the ARMS2 protein remain under debate. For a better understanding of functional impacts of A69S mutation, we performed a detailed analysis of an ARMS2 sequence with a broad set of bioinformatics tools...
March 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29311295/-cfh-and-arms2-genetic-risk-determines-progression-to-neovascular-age-related-macular-degeneration-after-antioxidant-and-zinc-supplementation
#11
Demetrios G Vavvas, Kent W Small, Carl C Awh, Brent W Zanke, Robert J Tibshirani, Rafal Kustra
We evaluated the influence of an antioxidant and zinc nutritional supplement [the Age-Related Eye Disease Study (AREDS) formulation] on delaying or preventing progression to neovascular AMD (NV) in persons with age-related macular degeneration (AMD). AREDS subjects ( n = 802) with category 3 or 4 AMD at baseline who had been treated with placebo or the AREDS formulation were evaluated for differences in the risk of progression to NV as a function of complement factor H ( CFH ) and age-related maculopathy susceptibility 2 ( ARMS2 ) genotype groups...
January 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29242907/skin-intrinsic-fluorescence-and-age-related-macular-degeneration-the-beaver-dam-eye-study
#12
Ronald Klein, Kristine E Lee, John D Maynard, Stacy M Meuer, Ronald E Gangnon, Barbara E K Klein
Purpose: To determine if skin intrinsic fluorescence (SIF), a noninvasive measure of advanced glycation endproducts and oxidative stress in skin is associated with AMD. Methods: SIF was measured with the SCOUT DS skin fluorescence spectrometer in a cross-sectional cohort study of 969 persons aged 68 to 102 years from the 1181 who participated in the 25-year follow-up examination in the Beaver Dam Eye Study (BDES) in 2014 to 2016. The SCOUT DS skin fluorescence spectrometer uses five light-emitting diodes, centered at 375 nm to 456 nm...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29145551/age-related-maculopathy-degeneration-by-generation
#13
Raphael R Goldacre, Tiarnan D L Keenan
No abstract text is available yet for this article.
December 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29145549/generational-differences-in-the-5-year-incidence-of-age-related-macular-degeneration
#14
Karen J Cruickshanks, David M Nondahl, Lauren J Johnson, Dayna S Dalton, Mary E Fisher, Guan-Hua Huang, Barbara E Klein, Ronald Klein, Carla R Schubert
Importance: Whether a reported decline in the risk of developing age-related macular degeneration (AMD) continued for people born during the Baby Boom years (1946-1964) or later is unknown. These data are important to plan for ocular health care needs in the 21st century. Objectives: To determine whether the 5-year risk for AMD declined by generation and to identify factors that contributed to improvement in risk. Design, Setting, and Participants: Data came from the longitudinal cohort Beaver Dam Eye Study (March 1, 1988, through September 15, 1990, and March 1, 1993, through June 15, 1995) and the Beaver Dam Offspring Study (June 8, 2005, through August 4, 2008, and July 12, 2010, through March 21, 2013)...
December 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29059963/deep-tessellated-retinal-image-detection-using-convolutional-neural-networks
#15
Xingzheng Lyu, Hai Li, Yi Zhen, Xin Ji, Sanyuan Zhang
Tessellation in fundus is not only a visible feature for aged-related and myopic maculopathy but also confuse retinal vessel segmentation. The detection of tessellated images is an inevitable processing in retinal image analysis. In this work, we propose a model using convolutional neural network for detecting tessellated images. The input to the model is pre-processed fundus image, and the output indicate whether this photograph has tessellation or not. A database with 12,000 colour retinal images is collected to evaluate the classification performance...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29025174/-change-in-therapy-of-neovascular-age-related-macular-degeneration-diabetic-maculopathy-and-macular-edema-after-retinal-vein-occlusion
#16
Matthias Grüb, Ioannis Lamprakis, Christoph Reichel
Background Therapy of neovascular age-related macular degeneration, diabetic maculopathy and macular edema after retinal vein occlusion has changed fundamentally since the introduction of anti-VEGF therapy more than 10 years ago. With the technological progress in ocular coherence tomography (OCT) functional criteria have been replaced by more morphological criteria. Contract law and administrative problems have been improved but not solved totally. Patients/Materials and Methods In a retrospective study, 207 eyes of 157 patients who presented between January 2007 and October 2013 with neovascular age-related macular degeneration, diabetic maculopathy or macular edema after retinal vein occlusion were analyzed...
October 12, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28924340/hypotony-management-through-transconjunctival-scleral-flap-resuturing-analysis-of-surgical-outcomes-and-success-predictors
#17
Ana Luiza B Scoralick, Izabela Almeida, Michele Ushida, Diego T Dias, Syril Dorairaj, Tiago S Prata, Fábio N Kanadani
AIM: To investigate surgical outcomes and success predictors of transconjunctival scleral flap resuturing for the management of hypotony due to overfiltration following trabeculectomy with mitomycin C. MATERIALS AND METHODS: Noncomparative, retrospective, interventional case series in which all glaucoma patients from two glaucoma services undergoing transconjunctival scleral flap resuturing between May 2012 and July 2016 were enrolled. Included eyes had to have hypotony [intraocular pressure (IOP) < 6 mm Hg] and/or hypotony maculopathy caused by excessive filtration following trabeculectomy...
May 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/28915445/exploring-the-association-of-rs10490924-polymorphism-with-age-related-macular-degeneration-an-in-silico-approach
#18
Farhad Jahanfar, Hamed Hamishehkar
The polymorphism rs10490924 (A69S) in the age-related maculopathy susceptibility 2 (ARMS2) gene is highly associated with age-related macular degeneration, which is the leading cause of blindness among the elderly population. The ARMS2 gene encodes a putative small (11kDa) protein, which the function and localization of the ARMS2 protein remain under debate. For a better understanding of functional impacts of the A69S mutation, we performed a detailed analysis of the ARMS2 sequence with a broad set of bioinformatics tools...
September 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28884200/spatial-distribution-of-early-red-lesions-is-a-risk-factor-for-development-of-vision-threatening-diabetic-retinopathy
#19
Giovanni Ometto, Phil Assheton, Francesco Calivá, Piotr Chudzik, Bashir Al-Diri, Andrew Hunter, Toke Bek
AIMS/HYPOTHESIS: Diabetic retinopathy is characterised by morphological lesions related to disturbances in retinal blood flow. It has previously been shown that the early development of retinal lesions temporal to the fovea may predict the development of treatment-requiring diabetic maculopathy. The aim of this study was to map accurately the area where lesions could predict progression to vision-threatening retinopathy. METHODS: The predictive value of the location of the earliest red lesions representing haemorrhages and/or microaneurysms was studied by comparing their occurrence in a group of individuals later developing vision-threatening diabetic retinopathy with that in a group matched with respect to diabetes type, age, sex and age of onset of diabetes mellitus who did not develop vision-threatening diabetic retinopathy during a similar observation period...
September 7, 2017: Diabetologia
https://www.readbyqxmd.com/read/28878022/drusen-in-patient-derived-hipsc-rpe-models-of-macular-dystrophies
#20
Chad A Galloway, Sonal Dalvi, Sandy S C Hung, Leslie A MacDonald, Lisa R Latchney, Raymond C B Wong, Robyn H Guymer, David A Mackey, David S Williams, Mina M Chung, David M Gamm, Alice Pébay, Alex W Hewitt, Ruchira Singh
Age-related macular degeneration (AMD) and related macular dystrophies (MDs) are a major cause of vision loss. However, the mechanisms underlying their progression remain ill-defined. This is partly due to the lack of disease models recapitulating the human pathology. Furthermore, in vivo studies have yielded limited understanding of the role of specific cell types in the eye vs. systemic influences (e.g., serum) on the disease pathology. Here, we use human induced pluripotent stem cell-retinal pigment epithelium (hiPSC-RPE) derived from patients with three dominant MDs, Sorsby's fundus dystrophy (SFD), Doyne honeycomb retinal dystrophy/malattia Leventinese (DHRD), and autosomal dominant radial drusen (ADRD), and demonstrate that dysfunction of RPE cells alone is sufficient for the initiation of sub-RPE lipoproteinaceous deposit (drusen) formation and extracellular matrix (ECM) alteration in these diseases...
September 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
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