keyword
MENU ▼
Read by QxMD icon Read
search

d dimer for pulmonary embolism

keyword
https://www.readbyqxmd.com/read/29760845/ruling-out-pulmonary-embolism-in-patients-with-high-pretest-probability
#1
Murtaza Akhter, Jeffrey Kline, Bikash Bhattarai, Mark Courtney, Christopher Kabrhel
Introduction: The American College of Emergency Physicians guidelines recommend more aggressive workup beyond imaging alone in patients with a high pretest probability (PTP) of pulmonary embolism (PE). However, the ability of multiple tests to safely rule out PE in high PTP patients is not known. We sought to measure the ability of negative computed tomography pulmonary angiography (CTPA) along with negative D-dimer to rule out PE in these high-risk patients. Methods: We analyzed data from a previous prospective observational study conducted in 12 emergency departments (ED)...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29753834/age-adjusted-versus-clinical-probability-adjusted-d-dimer-to-exclude-pulmonary-embolism
#2
Sarah Takach Lapner, Scott M Stevens, Scott C Woller, Gregory Snow, Clive Kearon
INTRODUCTION: A low D-dimer can exclude suspected pulmonary embolism (PE) in cases with low or intermediate clinical probability of disease. Yet D-dimer is nonspecific, so many cases without PE require imaging. D-dimer's specificity is improved by increasing the threshold for a positive test with age (age × 10 ng/mL; age-adjusted D-dimer; AADD) or clinical probability of PE (1000 ng/mL if low and 500 ng/mL if intermediate clinical probability; clinical probability-adjusted D-dimer; CPADD)...
May 5, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29745767/a-proof-of-concept-for-epidemiological-research-using-structured-reporting-with-pulmonary-embolism-as-a-use-case
#3
Pinto Dos Santos Daniel, Scheibl Sonja, Arnhold Gordon, Maehringer-Kunz Aline, Düber Christoph, Mildenberger Peter, Kloeckner Roman
OBJECTIVE: This paper studies the possibilities of an integrated IT-based workflow for epidemiological research in pulmonary embolism using freely available tools and structured reporting. METHODS: We included a total of 521 consecutive cases which had been referred to the radiology department for computed tomography pulmonary angiography (CTPA) with suspected pulmonary embolism (PE). Free-text reports were transformed into structured reports using a freely available IHE-MRRT-compliant reporting platform...
May 10, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29710413/automated-pulmonary-embolism-risk-classification-and-guideline-adherence-for-computed-tomography-pulmonary-angiography-ordering
#4
Christian A Koziatek, Emma Simon, Leora I Horwitz, Danil V Makarov, Silas W Smith, Simon Jones, Soterios Gyftopoulos, Jordan L Swartz
BACKGROUND: The assessment of clinical guideline adherence for the evaluation of pulmonary embolism (PE) via computed tomography pulmonary angiography (CTPA) currently requires either labor-intensive, retrospective chart review or prospective collection of PE risk scores at the time of CTPA order. The recording of clinical data in a structured manner in the electronic health record (EHR) may make it possible to automate the calculation of a patient's PE risk classification and determine whether the CTPA order was guideline concordant...
April 30, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29707339/effect-of-low-molecular-weight-heparin-on-venous-thromboembolism-disease-in-thoracotomy-patients-with-cancer
#5
Jun Dong, Jia Wang, Yuan Feng, Li-Ping Qi, Hua Fang, Guo-Dong Wang, Zhou-Qiao Wu, Hong-Zhi Wang, Yue Yang, Qing Li
Background: Much attention has been given to venous thromboembolism (VTE) disease, and many guidelines for prophylaxis have been published. However, there are few published data on patients who underwent thoracotomy. This study is to compare the effect of low molecular weight heparin (LMWH) combined mechanical approaches with mechanical approaches alone in prevention of VTE in the post thoracotomy cancer patients. Methods: This study used a prospective, randomized-controlled design...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29703562/d-dimer-levels-in-vte-patients-with-distal-and-proximal-clots
#6
Adam J Singer, Hui Zheng, Samuel Francis, Gregory J Fermann, Anne Marie Chang, Blair A Parry, Nick Giordano, Christopher Kabrhel
OBJECTIVES: There is growing evidence that venous thromboembolism (VTE) patients with distal clots (distal calf deep vein thrombosis [DVT] and sub-segmental pulmonary embolism [PE]) may not routinely benefit from anticoagulation. We compared the D-dimer levels in VTE patients with distal and proximal clots. METHODS: We conducted a multinational, prospective observational study of low-to-intermediate risk adult patients presenting to the emergency department (ED) with suspected VTE...
April 21, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29682728/clinical-effects-of-antiplatelet-drugs-and-statins-on-d-dimer-levels
#7
Suzanne Schol-Gelok, Tom van der Hulle, Joseph S Biedermann, Teun van Gelder, Frederikus A Klok, Liselotte M van der Pol, Jorie Versmissen, Menno V Huisman, Marieke J H A Kruip
BACKGROUND: Acute pulmonary embolism may be ruled out by combining non-high clinical probability and a normal D-dimer level. Both antiplatelet drugs and HMG-CoA reductase inhibitors (statins) have been associated with effects on thrombus formation, potentially influencing D-dimer levels in this setting, leading to a higher rate of false-negative tests. Therefore we determined whether D-dimer levels in patients with suspected pulmonary embolism are affected by concomitant use of antiplatelet drugs and/or statins and evaluated if the effect of antiplatelet drugs or statins might affect diagnostic accuracy...
April 22, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29675617/is-acute-pulmonary-embolism-more-severe-in-the-presence-of-obstructive-sleep-apnea-results-from-an-observational-cohort-study
#8
Dinah Konnerth, Florian Schwarz, Michael Probst, Martin Seidler, Tanja Wagner, Christian Faul, Wolfgang von Scheidt, Martin Schwaiblmair, Thomas M Berghaus
Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly older (p < 0.001), had significantly impaired renal (p < 0.001) and left ventricular functions (p = 0.003), showed significantly elevated troponin I (p = 0.005) and D-dimer levels (p = 0...
April 19, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29674240/the-impact-of-antipsychotics-as-a-risk-factor-for-thromboembolism
#9
REVIEW
Ewa A Ogłodek, Marek J Just, Anna D Grzesińska, Aleksander Araszkiewicz, Adam R Szromek
Patients with schizophrenia are predisposed toward developing cardiovascular disease. Although neuroleptics affect the cardiovascular system, it is also important to consider the consequences of the disease itself such as lower physical activity due to living on disability pension, inadequate nutrition, and/or nicotine addiction, being more common among patients with schizophrenia versus the general population. All these factors combined lead to an increased risk of death caused by cardiovascular conditions in schizophrenic patients...
December 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29660351/association-of-low-hemoglobin-with-symptomatic-venous-thromboembolism-in-acutely-ill-hospitalized-medical-patients-an-apex-trial-substudy
#10
Gerald Chi, C Michael Gibson, Adrian F Hernandez, Russell D Hull, Syed Hassan A Kazmi, Ahmed Younes, Sargun S Walia, Anmol Pitliya, Amandeep Singh, Farima Kahe, Arzu Kalayci, Tarek Nafee, Mathieu Kerneis, Fahad AlKhalfan, Alexander T Cohen, Robert A Harrington, Samuel Z Goldhaber
BACKGROUND: Anemia is a common finding and independent predictor for adverse outcomes in hospitalized patients with medical illness. It remains unclear whether anemia is a risk factor for venous thromboembolism and whether the presence of anemia can refine risk assessment for prediction of venous thromboembolism, thereby adding incremental utility to a validated model. METHODS: In the APEX trial, 7,513 hospitalized medical patients were randomized to receive either betrixaban or standard-of-care enoxaparin for thromboprophylaxis...
April 13, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29656169/international-multicenter-evaluation-of-a-new-d-dimer-assay-for-the-exclusion-of-venous-thromboembolism-using-standard-and-age-adjusted-cut-offs
#11
Blair Alden Parry, Anna Marie Chang, Sebastian M Schellong, Stacey L House, Gregory J Fermann, Erin K Deadmon, Nicholas J Giordano, Yuchiao Chang, Jason Cohen, Nancy Robak, Adam J Singer, Mary Mulrow, Ellen T Reibling, Samuel Francis, S Michelle Griffin, Jürgen H Prochaska, Barbara Davis, Patricia McNelis, Joao Delgado, Philipp Kümpers, Nikos Werner, Nina T Gentile, Eli Zeserson, Philipp S Wild, Alexander T Limkakeng, Elizabeth Lea Walters, Frank LoVecchio, Daniel Theodoro, Judd E Hollander, Christopher Kabrhel
INTRODUCTION: We sought to determine the test characteristics of an automated INNOVANCE D-dimer assay for the exclusion of pulmonary embolism (PE) and deep venous thrombosis (DVT) in emergency department (ED) patients using standard and age-adjusted cut-offs. METHODS: Cross-sectional, international, multicenter study of consecutive patients with suspected DVT or PE in 24 centers (18 USA, 6 Europe). Evaluated patients had low or intermediate Wells PE or DVT scores...
April 5, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29623992/diagnostic-utility-of-an-age-specific-cut-off-for-d-dimer-for-pulmonary-embolism-assessment-when-used-with-various-pulmonary-embolism-risk-scores
#12
Imogen Ackerly, Sharon Klim, James McFarlane, Anne-Maree Kelly
This retrospective cohort study compared the diagnostic utility (sensitivity, specificity and negative predictive value (NPV)) of the age-times-10 adjusted d-dimer cut-off used in combination with the original and simplified Well's pulmonary embolism (PE) scores and the original and simplified revised Geneva scores to identify patients in whom PE is classified as unlikely according to each score. The PE risk scores performed similarly with high sensitivity (97.6, 97.1, 96.9 and 97.1% respectively) and NPV (99...
April 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29603819/multicenter-evaluation-of-the-years-criteria-in-emergency-department-patients-evaluated-for-pulmonary-embolism
#13
Christopher Kabrhel, Astrid Van Hylckama Vlieg, Alona Muzikanski, Adam Singer, Gregory J Fermann, Samuel Francis, Alex Lim Kakeng, Ann Marie Chang, Nicholas Giordano, Blair Parry
BACKGROUND: It may be possible to safely rule out pulmonary embolism (PE) in patients with low pre-test probability (PTP) using a higher than standard D-dimer threshold. The YEARS criteria, which includes three questions from the Wells PE Score to identify low PTP patients and a variable D-dimer threshold, was recently shown to decrease the need for imaging to rule out PE by 14% in a multicenter study in the Netherlands. However, the YEARS approach has not been studied in the United States...
March 31, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29536476/diagnosis-of-acute-pulmonary-embolism
#14
Marc Righini, Helia Robert-Ebadi
During the last three decades, considerable advances in the management of patients with suspected pulmonary embolism (PE) have improved diagnostic accuracy and made management algorithms safer, easier to use and well standardized. These diagnostic algorithms are mainly based on the assessment of clinical pretest probability, D-Dimer measurement and imaging tests, mainly computed tomography pulmonary angiography (CTPA). These diagnostic algorithms allow a safe and cost-effective diagnosis for most patients with suspected PE...
February 2018: Hämostaseologie
https://www.readbyqxmd.com/read/29505695/age-adjusted-d-dimer-cut-off-leads-to-more-efficient-diagnosis-of-venous-thromboembolism-in-the-emergency-department-a-comparison-of-four-assays
#15
M Farm, A J Siddiqui, L Onelöv, I Järnberg, J Eintrei, F Maskovic, A Kallner, M Holmström, J P Antovic
Essentials Age-adjusted D-dimer cut-offs decrease the false positives in the elderly. Four D-dimer assays were compared in venous thromboembolism outpatients in an emergency ward. Age-adjusted cut-off resulted in improved specificity with maintained sensitivity for all assays. There was a substantial decrease in false positive results, especially in the older population. SUMMARY: Background The study compares different D-dimer assays and age-adjusted cut-offs in outpatients with suspected venous thromboembolism (VTE)...
May 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29504087/the-diagnostic-utility-of-d-dimer-and-other-clinical-variables-in-pregnant-and-post-partum-patients-with-suspected-acute-pulmonary-embolism
#16
Hyun Choi, Dinesh Krishnamoorthy
BACKGROUND: Pulmonary embolism (PE) during pregnancy remains one of the leading causes of maternal morbidity and mortality in the developed world. However, there is a paucity of high-quality evidence resulting in a lack of consensus in managing this group of patients. The aims of the study were to address the diagnostic utility of D-dimer for suspected PE in pregnant and post-partum patients and to identify any clinical presentation variables that are predictors of PE in this group of patients...
March 5, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29502865/use-of-the-d-dimer-for-detecting-pulmonary-embolism-in-the-emergency-department
#17
Nancy Glober, Christopher R Tainter, Jesse Brennan, Mark Darocki, Morgan Klingfus, Michelle Choi, Brenna Derksen, Frances Rudolf, Gabriel Wardi, Edward Castillo, Theodore Chan
BACKGROUND: Assessment for pulmonary embolism (PE) in the emergency department (ED) remains complex, involving clinical decision tools, blood tests, and imaging. OBJECTIVE: Our objective was to examine the test characteristics of the high-sensitivity d-dimer for the diagnosis of PE at our institution and evaluate use of the d-dimer and factors associated with a falsely elevated d-dimer. METHODS: We retrospectively collected data on adult patients evaluated with a d-dimer and computed tomography (CT) pulmonary angiogram or ventilation perfusion scan at two EDs between June 4, 2012 and March 30, 2016...
May 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29493500/-the-choice-of-diagnostic-modality-for-acute-pulmonary-embolism
#18
Jonas Munch Nielsen, Jann Mortensen
The diagnosis of pulmonary embolism (PE) relies on clinical assessment, D-dimer test and diagnostic imaging. Modern CT pulmonary angiography (CTPA), ventilation/perfusion  single-photon emission computed tomography (SPECT) and SPECT/CT are rather equal in terms of sensitivity, specificity and inconclusive results for the diagnosis of PE, outper-forming planar lung scintigraphy. Furthermore, SPECT/CT and CTPA can both provide important information regarding differential diagnoses. Thus, the choice of primary diag-nostic modality relies on local expertise, availability and special circumstances like radiation dose, contraindications and the clinical urgency...
February 19, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29460484/sex-specific-performance-of-pre-imaging-diagnostic-algorithms-for-pulmonary-embolism
#19
T E van Mens, L M van der Pol, N van Es, I M Bistervels, A T A Mairuhu, T van der Hulle, F A Klok, M V Huisman, S Middeldorp
Essentials Decision rules for pulmonary embolism are used indiscriminately despite possible sex-differences. Various pre-imaging diagnostic algorithms have been investigated in several prospective studies. When analysed at an individual patient data level the algorithms perform similarly in both sexes. Estrogen use and male sex were associated with a higher prevalence in suspected pulmonary embolism. SUMMARY: Background In patients suspected of pulmonary embolism (PE), clinical decision rules are combined with D-dimer testing to rule out PE, avoiding the need for imaging in those at low risk...
May 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29435465/missed-massive-pulmonary-embolism-and-the-hidden-threat-of-a-distal-deep-vein-thrombosis
#20
Cynthia Wong
A 47-year-old woman presented to her GP (general practitioner) surgery with a left leg pain of 4 days duration after a recent 4-hour flight. She was taking the oral combined contraceptive pill and had no past medical history. She had a low predictive Wells score for deep vein thrombosis, but her D-dimer was positive, so she had a proximal lower limb vein ultrasound scan as per the National Institute for Clinical Excellence guidelines, which was negative. Two days later, she presented to the emergency department with a collapse and dyspnea...
January 2018: Journal of Investigative Medicine High Impact Case Reports
keyword
keyword
62038
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"