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https://www.readbyqxmd.com/read/28062401/a-conference-of-new-ideas-in-cancer-challenging-dogmas
#1
Varsha Gandhi, Rakesh Jalali
In 2016, Tata Memorial Center in Mumbai, India, reached its platinum jubilee milestone (75 years), which was celebrated with conferences. The first of these was entitled, "A Conference of New Ideas in Cancer - Challenging Dogmas." The aim of the conference was to take an honest appraisal about the state of cancer research today, to debate "currently entrenched versus contrarian viewpoints" and to reflect upon whether the current research and therapeutic strategies are appropriate and whether resources are being optimally utilized in meaningful ways...
January 6, 2017: Cancer Research
https://www.readbyqxmd.com/read/28032091/comparative-evaluation-of-different-volumes-of-70-alcohol-in-celiac-plexus-block-for-upper-abdominal-malignsancies
#2
Archana Dolly, Sarita Singh, Ravi Prakash, Jaishri Bogra, Anita Malik, Vinita Singh
CONTEXT: Celiac plexus block (CPB) (is an effective way to reduce cancer-associated pain in upper abdominal malignancies. AIMS: To evaluate the efficacy and safety of different volumes of 70% alcohol in CPB. SETTINGS AND DESIGN: Prospective, randomized, controlled clinical study. SUBJECTS AND METHODS: Thirty patients of carcinoma gall bladder were randomly divided into three groups (n = 10) to receive 20, 30, and 40 ml of 70% alcohol in CPB...
October 2016: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28009057/indole-an-evolutionarily-conserved-influencer-of-behavior-across-kingdoms
#3
Jeffery K Tomberlin, Tawni L Crippen, Guoyao Wu, Ashleigh S Griffin, Thomas K Wood, Rebecca M Kilner
Indole is a key environmental cue that is used by many organisms. Based on its biochemistry, we suggest indole is used so universally, and by such different organisms, because it derives from the metabolism of tryptophan, a resource essential for many species yet rare in nature. These properties make it a valuable, environmental cue for resources almost universally important for promoting fitness. We then describe how indole is used to coordinate actions within organisms, to influence the behavior of conspecifics and can even be used to change the behavior of species that belong to other kingdoms...
December 23, 2016: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28002355/honest-labor-bears-a-lovely-face-will-late-life-unemployment-impact-health-and-satisfaction-in-retirement
#4
Maren Wright Voss, Wendy Church Birmingham, Lori Wadsworth, Wei Chen, Jerry Bounsanga, Yushan Gu, Man Hung
OBJECTIVE: Unemployment among older adults during recessionary cycles has been tied to early retirement decisions and negative health outcomes. This study explored episodes of unemployment experienced between age 50 and retirement as predictors of retirement age and health outcomes. METHODS: A total of 1540 participants from the U.S. Health and Retirement Study aged 50 years and older who transitioned from workforce to retirement were analyzed with descriptive statistics and multiple regression controlling for unemployment, demographics, and health status...
December 20, 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28001442/-it-s-just-not-the-culture-a-qualitative-study-exploring-residents-perceptions-of-the-impact-of-institutional-culture-on-feedback
#5
Subha Ramani, Sarah E Post, Karen Könings, Karen Mann, Joel T Katz, Cees van der Vleuten
: Phenomenon: Competency-based medical education requires ongoing performance-based feedback for professional growth. In several studies, medical trainees report that the quality of faculty feedback is inadequate. Sociocultural barriers to feedback exchanges are further amplified in graduate and postgraduate medical education settings, where trainees serve as frontline providers of patient care. Factors that affect institutional feedback culture, enhance feedback seeking, acceptance, and bidirectional feedback warrant further exploration in these settings...
December 21, 2016: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/27989469/targeted-and-untargeted-characterisation-of-free-and-glycosylated-simple-phenols-in-cocoa-beans-using-high-resolution-tandem-mass-spectrometry-q-orbitrap
#6
C Barnaba, T Nardin, A Pierotti, M Malacarne, R Larcher
Free simple phenols have positive effects on health and influence the organoleptic profile of cocoa products, contributing towards defining their aroma and nutritional properties. Glycosidically bound simple phenols can be hydrolysed during the production phase to the corresponding free forms, and thus potentially contribute to the final sensory profile. In this work, 60 samples of Forastero cocoa beans from all over the world were analysed, combining on-line solid phase extraction (SPE) clean-up with ultra-high performance liquid chromatography (UHPLC), coupled with high resolution mass spectrometry...
January 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27965501/effect-of-surface-treatments-on-the-bond-strength-to-turkom-cera-all-ceramic-material
#7
Abdul Aa Razak, Mohamed I Abu-Hassan, Bandar Ma Al-Makramani, Fuad A Al-Sanabani, Ibrahim Z Al-Shami, Hosain M Almansour
AIM: The aim of this study was to evaluate the effect of surface treatments on shear bond strength (SBS) of Turkom-Cera (Turkom-Ceramic (M) Sdn. Bhd., Puchong, Malaysia) all-ceramic material cemented with resin cement Panavia-F (Kuraray Medical Inc., Okayama, Japan). MATERIALS AND METHODS: Forty Turkom-Cera ceramic disks (10 mm × 3 mm) were prepared and randomly divided into four groups. The disks were wet ground to 1000-grit and subjected to four surface treatments: (1) No treatment (Control), (2) sandblasting, (3) silane application, and (4) sandblasting + silane...
November 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27965486/comparison-of-shear-bond-strength-and-microleakage-of-various-bulk-fill-bioactive-dentin-substitutes-an-in-vitro-study
#8
Fahad I Alkhudhairy, Zeeshan H Ahmad
INTRODUCTION: Various bulk-fill materials depending on their composition, viscosity, and flow ability have different physical and mechanical properties. The aim of this in vitro study was to determine and compare the shear bond strength and microleakage properties of activa restorative with other bulk-fill restorative materials surefil (SDR), Biodentine, ever X posterior. MATERIALS AND METHODS: Forty permanent premolars were selected for shear bond strength, and 20 permanent premolars were selected with class II cavities on mesial and distal side for microleakage...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27936045/field-crickets-compensate-for-unattractive-static-long-distance-call-components-by-increasing-dynamic-signalling-effort
#9
Emily M McAuley, Susan M Bertram
The evolution of multiple sexual signals presents a dilemma since individuals selecting a mate should pay attention to the most honest signal and ignore the rest; however, multiple signals may evolve if, together, they provide more information to the receiver than either one would alone. Static and dynamic signals, for instance, can act as multiple messages, providing information on different aspects of signaller quality that reflect condition at different time scales. While the nature of static signals makes them difficult or impossible for individuals to augment, dynamic signals are much more susceptible to temporary fluctuations in effort...
2016: PloS One
https://www.readbyqxmd.com/read/27927286/effect-of-casting-atmosphere-on-the-marginal-deficiency-and-misfit-of-ni-cr-alloys-with-and-without-beryllium
#10
Leandro J da Silva, Monica B Leal, Mariana L C Valente, Denise T de Castro, Valéria O Pagnano, Andréa C Dos Reis, Osvaldo L Bezzon
STATEMENT OF PROBLEM: The marginal adaptation of prosthetic crowns is still a significant clinical problem. PURPOSE: The purpose of this in vitro study was to evaluate the marginal deficiency and misfit of Ni-Cr alloys with and without beryllium under different casting conditions. MATERIAL AND METHODS: Four casting conditions were selected: flame-torch, induction/argon, induction/vacuum, and induction/air; and 2 alloys were used, Ni-Cr-Be and Ni-Cr...
December 4, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27904091/erratum-to-application-of-addition-cured-silicone-denture-relining-materials-to-adjust-mouthguards
#11
Shintaro Fukasawa, Hiroshi Churei, Ruman Uddin Chowdhury, Takahiro Shirako, Sharika Shahrin, Abhishekhi Shrestha, Takahiro Wada, Motohiro Uo, Hidekazu Takahashi, Toshiaki Ueno
The purposes of this study were to examine the shock absorption capability of addition-cured silicone denture relining materials and the bonding strength of addition-cured silicone denture relining materials and a commercial mouthguard material to determine its applicability to mouthguard adjustment. Two addition-cured silicone denture relining materials were selected as test materials. The impact test was applied by a free-falling steel ball. On the other hand, bonding strength was determined by a delamination test...
2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27903876/handicap-principle-implies-emergence-of-dimorphic-ornaments
#12
Sara M Clifton, Rosemary I Braun, Daniel M Abrams
Species spanning the animal kingdom have evolved extravagant and costly ornaments to attract mating partners. Zahavi's handicap principle offers an elegant explanation for this: ornaments signal individual quality, and must be costly to ensure honest signalling, making mate selection more efficient. Here, we incorporate the assumptions of the handicap principle into a mathematical model and show that they are sufficient to explain the heretofore puzzling observation of bimodally distributed ornament sizes in a variety of species...
November 30, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27898142/sv%C3%A3-ra-samtal-med-patienter-tr%C3%A3-nas-p%C3%A3-kurs-med-sk%C3%A3-despelare-en-medveten-strategi-hj%C3%A3-lper-b%C3%A3-de-l%C3%A3-kare-och-patient
#13
Anders Danielsson, Hanna Dahlstrand, Franziska Edvinsson, Mattias Tranberg, Anna Wrangsjö, Carl-Johan Fürst
The physician's communication skill influences the patient's mental and physical wellbeing, as well as the physician's own experience of stress. Most patients wish to be informed about their disease, by physicians who are honest, gives time, sustains hope, listens and shows compassion and empathy. Even though there are established guidelines on how to break bad news, the physician must find out and respond to the unique reactions and needs of each individual, in order to communicate successfully. There is no consensus on how to construct and evaluate communication skills training programs for physicians, and more RCT-studies are requested...
November 22, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27893213/reliability-and-validity-of-data-obtained-from-alcohol-cannabis-and-gambling-populations-on-amazon-s-mechanical-turk
#14
Hyoun S Kim, David C Hodgins
Researchers recently have begun using Mechanical Turk (MTurk), an online crowdsourcing platform, to recruit addiction populations. However, whether the data obtained from substance users and gamblers on MTurk are reliable and valid is unknown. Herein, we assessed the internal and retest reliability of and concurrent and convergent validity of data obtained from addiction populations on MTurk. Current drinkers (N = 208), cannabis users (N = 200), and gamblers (N = 200) residing in the United States completed measures of alcohol, cannabis, and gambling severity, psychological constructs (e...
November 28, 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/27883016/sexual-display-complexity-varies-non-linearly-with-age-and-predicts-breeding-status-in-greater-flamingos
#15
Charlotte Perrot, Arnaud Béchet, Céline Hanzen, Antoine Arnaud, Roger Pradel, Frank Cézilly
The long-lived greater flamingo (Phoenicopterus roseus) is famous for performing conspicuous group displays during which adults try to acquire a new mate each year with varying success. We examined variation in the sexual display complexity (SDC) of wild flamingos aged between 4 and 37 yrs. SDC was defined as the product of richness (the number of different display movements) and versatility (the number of transitions between movements) within a 5 min behavioral sequence. In both sexes, date in the pairing season had a linear and positive effect on SDC, whereas age had a quadratic effect, with SDC increasing until about age 20yrs, and declining afterwards...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27881746/neotropical-wrens-learn-new-duet-rules-as-adults
#16
Karla D Rivera-Cáceres, Esmeralda Quirós-Guerrero, Marcelo Araya-Salas, William A Searcy
Although song development in songbirds has been much studied as an analogue of language development in humans, the development of vocal interaction rules has been relatively neglected in both groups. Duetting avian species provide an ideal model to address the acquisition of interaction rules as duet structure involves time and pattern-specific relationships among the vocalizations from different individuals. In this study, we address the development of the most striking properties of duets: the specific answering rules that individuals use to link their own phrase types to those of their partners (duet codes) and precise temporal coordination...
November 30, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27881524/why-articles-are-retracted-a-retrospective-cross-sectional-study-of-retraction-notices-at-biomed-central
#17
Elizabeth C Moylan, Maria K Kowalczuk
OBJECTIVES: To assess why articles are retracted from BioMed Central journals, whether retraction notices adhered to the Committee on Publication Ethics (COPE) guidelines, and are becoming more frequent as a proportion of published articles. DESIGN/SETTING: Retrospective cross-sectional analysis of 134 retractions from January 2000 to December 2015. RESULTS: 134 retraction notices were published during this timeframe. Although they account for 0...
November 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/27878160/chemo-enzymatic-modification-of-eukaryotic-mrna
#18
Fabian Muttach, Nils Muthmann, Andrea Rentmeister
Messenger RNA may not be very abundant in the cell but its central role in gene expression is indisputable. In addition to being the template for translation it can be subject for a variety of regulatory mechanisms affecting gene expression, ranging from simple structural changes to modifications and active transport. To elucidate and potentially control the underlying changes in vitro and in cells, site-specific modification and labeling strategies are required. In this perspective, we introduce chemo-enzymatic concepts for posttranscriptional modification focusing on eukaryotic mRNAs...
November 23, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27878059/assessment-of-online-patient-education-materials-from-major-dermatologic-associations
#19
Ann M John, Elizabeth S John, David R Hansberry, William Clark Lambert
Objective: Patients increasingly use the internet to find medical information regarding their conditions and treatments. Physicians often supplement visits with written education materials. Online patient education materials from major dermatologic associations should be written at appropriate reading levels to optimize utility for patients. The purpose of this study is to assess online patient education materials from major dermatologic associations and determine if they are written at the fourth to sixth grade level recommended by the American Medical Association and National Institutes of Health...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27875473/committee-opinion-no-681-disclosure-and-discussion-of-adverse-events
#20
(no author information available yet)
Adverse outcomes, preventable or otherwise, are a reality of medical care. Most importantly, adverse events affect patients, but they also affect health care practitioners. Disclosing information about adverse events has benefits for the patient and the physician and, ideally, strengthens the patient-physician relationship and promotes trust. Studies show that after an adverse outcome, patients expect and want timely and full disclosure of the event, an acknowledgment of responsibility, an understanding of what happened, expressions of sympathy, and a discussion of what is being done to prevent recurrence...
December 2016: Obstetrics and Gynecology
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