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https://www.readbyqxmd.com/read/27906224/analysis-of-sinusoidally-modulated-chirped-laser-pulses-by-temporally-encoded-spectral-shifting
#1
N H Matlis, A Maksimchuk, V Yanovsky, W P Leemans, M C Downer
We present an analytical formalism elucidating how information is stored in chirped optical probes by describing the effects of sinusoidal temporal modulations on the electric field. We show that the modulations produce spectral sidebands which can be interpreted as temporal sidebands due to the time-wavelength mapping, an effect we call temporally encoded spectral shifting (TESS). A derivation is presented for the case of chirped-pulse spectral interferometry showing how to recover both the amplitude and the periodicity of the modulation from a Fourier transform of the interferogram...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27905885/mefit-merging-and-filtering-tool-for-illumina-paired-end-reads-for-16s-rrna-amplicon-sequencing
#2
Hardik I Parikh, Vishal N Koparde, Steven P Bradley, Gregory A Buck, Nihar U Sheth
BACKGROUND: Recent advances in next-generation sequencing have revolutionized genomic research. 16S rRNA amplicon sequencing using paired-end sequencing on the MiSeq platform from Illumina, Inc., is being used to characterize the composition and dynamics of extremely complex/diverse microbial communities. For this analysis on the Illumina platform, merging and quality filtering of paired-end reads are essential first steps in data analysis to ensure the accuracy and reliability of downstream analysis...
December 1, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27905444/ghost-imaging-with-atoms
#3
R I Khakimov, B M Henson, D K Shin, S S Hodgman, R G Dall, K G H Baldwin, A G Truscott
Ghost imaging is a counter-intuitive phenomenon-first realized in quantum optics-that enables the image of a two-dimensional object (mask) to be reconstructed using the spatio-temporal properties of a beam of particles with which it never interacts. Typically, two beams of correlated photons are used: one passes through the mask to a single-pixel (bucket) detector while the spatial profile of the other is measured by a high-resolution (multi-pixel) detector. The second beam never interacts with the mask. Neither detector can reconstruct the mask independently, but temporal cross-correlation between the two beams can be used to recover a 'ghost' image...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27905060/perioperative-risk-adjustment-for-total-shoulder-arthroplasty-are-simple-clinically-driven-models-sufficient
#4
David N Bernstein, Aakash Keswani, David Ring
BACKGROUND: There is growing interest in value-based health care in the United States. Statistical analysis of large databases can inform us of the factors associated with and the probability of adverse events and unplanned readmissions that diminish quality and add expense. For example, increased operating time and high blood urea nitrogen (BUN) are associated with adverse events, whereas patients on antihypertensive medications were more likely to have an unplanned readmission. Many surgeons rely on their knowledge and intuition when assessing the risk of a procedure...
November 30, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27903906/eupathdb-the-eukaryotic-pathogen-genomics-database-resource
#5
Cristina Aurrecoechea, Ana Barreto, Evelina Y Basenko, John Brestelli, Brian P Brunk, Shon Cade, Kathryn Crouch, Ryan Doherty, Dave Falke, Steve Fischer, Bindu Gajria, Omar S Harb, Mark Heiges, Christiane Hertz-Fowler, Sufen Hu, John Iodice, Jessica C Kissinger, Cris Lawrence, Wei Li, Deborah F Pinney, Jane A Pulman, David S Roos, Achchuthan Shanmugasundram, Fatima Silva-Franco, Sascha Steinbiss, Christian J Stoeckert, Drew Spruill, Haiming Wang, Susanne Warrenfeltz, Jie Zheng
The Eukaryotic Pathogen Genomics Database Resource (EuPathDB, http://eupathdb.org) is a collection of databases covering 170+ eukaryotic pathogens (protists & fungi), along with relevant free-living and non-pathogenic species, and select pathogen hosts. To facilitate the discovery of meaningful biological relationships, the databases couple preconfigured searches with visualization and analysis tools for comprehensive data mining via intuitive graphical interfaces and APIs. All data are analyzed with the same workflows, including creation of gene orthology profiles, so data are easily compared across data sets, data types and organisms...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27903890/pharos-collating-protein-information-to-shed-light-on-the-druggable-genome
#6
Dac-Trung Nguyen, Stephen Mathias, Cristian Bologa, Soren Brunak, Nicolas Fernandez, Anna Gaulton, Anne Hersey, Jayme Holmes, Lars Juhl Jensen, Anneli Karlsson, Guixia Liu, Avi Ma'ayan, Geetha Mandava, Subramani Mani, Saurabh Mehta, John Overington, Juhee Patel, Andrew D Rouillard, Stephan Schürer, Timothy Sheils, Anton Simeonov, Larry A Sklar, Noel Southall, Oleg Ursu, Dusica Vidovic, Anna Waller, Jeremy Yang, Ajit Jadhav, Tudor I Oprea, Rajarshi Guha
The 'druggable genome' encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available. The Illuminating the Druggable Genome (IDG) program was initiated in 2014, has the goal of developing experimental techniques and a Knowledge Management Center (KMC) that would collect and organize information about protein targets from four families, representing the most common druggable targets with an emphasis on understudied proteins...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27903263/estimating-the-accuracy-of-muscle-response-testing-two-randomised-order-blinded-studies
#7
Anne M Jensen, Richard J Stevens, Amanda J Burls
BACKGROUND: Manual muscle testing (MMT) is a non-invasive assessment tool used by a variety of health care providers to evaluate neuromusculoskeletal integrity, and muscular strength in particular. In one form of MMT called muscle response testing (MRT), muscles are said to be tested, not to evaluate muscular strength, but neural control. One established, but insufficiently validated, application of MRT is to assess a patient's response to semantic stimuli (e.g. spoken lies) during a therapy session...
November 30, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27900701/elbow-instability-are-we-able-to-classify-it-review-of-the-literature-and-proposal-of-an-all-inclusive-classification-system
#8
REVIEW
A Marinelli, E Guerra, R Rotini
BACKGROUND: In the recent years, considerable improvements have come in biomechanical knowledge about the role of elbow stabilizers. In particular, the complex interactions among the different stabilizers when injured at the same time have been better understood. Anyway, uncertainties about both nomenclature and classification still exist in the definition of the different patterns of instability. MATERIAL AND METHODS: The authors examine the literature of the last 130 years about elbow instability classification, analyzing the intuitions and the value of each of them...
December 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27899908/commentary-incubation-and-intuition-in-creative-problem-solving
#9
COMMENT
Yuan Yuan, Wangbing Shen
No abstract text is available yet for this article.
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27899732/intrinsic-and-extrinsic-science-a-dialectic-of-scientific-fame
#10
Gregory J Feist
In this article, I argue that scientific fame and impact exists on a continuum from the mundane to the transformative/revolutionary. Ideally, one achieves fame and impact in science by synthesizing two extreme career prototypes: intrinsic and extrinsic research. The former is guided by interest, curiosity, passion, gut, and intuition for important untapped topics. The latter is guided by money, grants, and/or what is being published in top-tier journals. Assessment of fame and impact in science ultimately rests on productivity (publication) and some variation of its impact (citations)...
November 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27899707/the-influence-of-presentation-modality-on-the-social-comprehension-of-naturalistic-scenes-in-adults-with-autism-spectrum-disorder
#11
Haley M Gedek, Peter C Pantelis, Daniel P Kennedy
The comprehension of dynamically unfolding social situations is made possible by the seamless integration of multimodal information merged with rich intuitions about the thoughts and behaviors of others. We examined how high-functioning adults with autism spectrum disorder and neurotypical controls made a complex social judgment (i.e. rating the social awkwardness of scenes from a television sitcom) across three conditions that manipulated presentation modality-visual alone, transcribed text alone, or visual and auditory together...
November 29, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27899609/enabling-the-democratization-of-the-genomics-revolution-with-a-fully-integrated-web-based-bioinformatics-platform
#12
Po-E Li, Chien-Chi Lo, Joseph J Anderson, Karen W Davenport, Kimberly A Bishop-Lilly, Yan Xu, Sanaa Ahmed, Shihai Feng, Vishwesh P Mokashi, Patrick S G Chain
Continued advancements in sequencing technologies have fueled the development of new sequencing applications and promise to flood current databases with raw data. A number of factors prevent the seamless and easy use of these data, including the breadth of project goals, the wide array of tools that individually perform fractions of any given analysis, the large number of associated software/hardware dependencies, and the detailed expertise required to perform these analyses. To address these issues, we have developed an intuitive web-based environment with a wide assortment of integrated and cutting-edge bioinformatics tools in pre-configured workflows...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898160/haptic-feedback-improves-surgeons-user-experience-and-fracture-reduction-in-facial-trauma-simulation
#13
Sabine Girod, Sara C Schvartzman, Dyani Gaudilliere, Kenneth Salisbury, Rebeka Silva
Computer-assisted surgical (CAS) planning tools are available for craniofacial surgery, but are usually based on computer-aided design (CAD) tools that lack the ability to detect the collision of virtual objects (i.e., fractured bone segments). We developed a CAS system featuring a sense of touch (haptic) that enables surgeons to physically interact with individual, patient-specific anatomy and immerse in a three-dimensional virtual environment. In this study, we evaluated initial user experience with our novel system compared to an existing CAD system...
2016: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/27897317/thermodynamics-electrostatics-and-ionic-current-in-nanochannels-grafted-with-ph-responsive-end-charged-polyelectrolyte-brushes
#14
Guang Chen, Siddhartha Das
In this paper, we study the thermodynamics, electrostatics, and an external electric field driven ionic current in a pH-responsive, end-charged polyelectrolyte (PE) brush grafted nanochannel. By employing a mean field theory, we unravel a highly non-intuitive interplay of pH and electrolyte salt concentration in dictating the height of the end-charged PE brush. Larger pH or weak hydrogen ion concentration leads to maximum ionization of the charge-producing group - as a consequence, the resulting the electric double layer (EDL) energy get maximized causing a maximum deviation of the brush height from the value (d0 ) of the uncharged brush...
November 29, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27896840/virtual-angioscopy-and-3d-navigation-of-the-aorta
#15
António Cruz Tomás, Álvaro Laranjeira Santos, José Fragata
The objective of this study is to demonstrate the applicability of virtual angioscopy (VA) in different forms of aortic disease where the diagnosis is unclear or uncertain. Five cases are presented where VA helped to establish a correct diagnosis and to choose the best surgical strategy by providing an intuitive image of the aorta.
November 29, 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27895558/physics-of-the-mind
#16
Leonid I Perlovsky
Is it possible to turn psychology into "hard science"? Physics of the mind follows the fundamental methodology of physics in all areas where physics have been developed. What is common among Newtonian mechanics, statistical physics, quantum physics, thermodynamics, theory of relativity, astrophysics… and a theory of superstrings? The common among all areas of physics is a methodology of physics discussed in the first few lines of the paper. Is physics of the mind possible? Is it possible to describe the mind based on the few first principles as physics does? The mind with its variabilities and uncertainties, the mind from perception and elementary cognition to emotions and abstract ideas, to high cognition...
2016: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/27895239/making-space-for-spatial-proportions
#17
Percival G Matthews, Edward M Hubbard
The three target articles presented in this special issue converged on an emerging theme: the importance of spatial proportional reasoning. They suggest that the ability to map between symbolic fractions (like 1/5) and nonsymbolic, spatial representations of their sizes or magnitudes may be especially important for building robust fractions knowledge. In this commentary, we first reflect upon where these findings stand in a larger theoretical context, largely borrowed from mathematics education research. Next, we emphasize parallels between this work and emerging work suggesting that nonsymbolic proportional reasoning may provide an intuitive foundation for understanding fraction magnitudes...
November 28, 2016: Journal of Learning Disabilities
https://www.readbyqxmd.com/read/27893991/saclab-a-toolbox-for-saccade-analysis-to-increase-usability-of-eye-tracking-systems-in-clinical-ophthalmology-practice
#18
Laura Cercenelli, Guido Tiberi, Ivan Corazza, Giuseppe Giannaccare, Michela Fresina, Emanuela Marcelli
PURPOSE: Many open source software packages have been recently developed to expand the usability of eye tracking systems to study oculomotor behavior, but none of these is specifically designed to encompass all the main functions required for creating eye tracking tests and for providing the automatic analysis of saccadic eye movements. The aim of this study is to introduce SacLab, an intuitive, freely-available MATLAB toolbox based on Graphical User Interfaces (GUIs) that we have developed to increase the usability of the ViewPoint EyeTracker (Arrington Research, Scottsdale, AZ, USA) in clinical ophthalmology practice...
November 22, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27893300/the-use-of-robotic-and-laparoscopic-surgical-stapling-devices-during-minimally-invasive-colon-and-rectal-surgery-a-comparison
#19
Jeremy L Holzmacher, Samuel Luka, Madiha Aziz, Richard L Amdur, Samir Agarwal, Vincent Obias
PURPOSE: To date there exists no published study examining the safety and efficacy of the EndoWrist 45 (Intuitive Surgical, Inc.) robotic stapler. We compared outcomes between the robotic and comparable laparoscopic stapler in robotic-assisted colorectal procedures. MATERIALS AND METHODS: We conducted a retrospective review of 93 patients who underwent robotic-assisted colorectal surgery at our institution from 2012 to 2014. Surgeries included left, sigmoid, subtotal and total colectomies, and low anterior rectal resections...
November 28, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27891228/a-probabilistic-algorithm-to-process-geolocation-data
#20
Benjamin Merkel, Richard A Phillips, Sébastien Descamps, Nigel G Yoccoz, Børge Moe, Hallvard Strøm
BACKGROUND: The use of light level loggers (geolocators) to understand movements and distributions in terrestrial and marine vertebrates, particularly during the non-breeding period, has increased dramatically in recent years. However, inferring positions from light data is not straightforward, often relies on assumptions that are difficult to test, or includes an element of subjectivity. RESULTS: We present an intuitive framework to compute locations from twilight events collected by geolocators from different manufacturers...
2016: Movement Ecology
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