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https://www.readbyqxmd.com/read/28930311/universal-analytical-modeling-of-plasmonic-nanoparticles
#1
Renwen Yu, Luis M Liz-Marzán, F Javier García de Abajo
Control over the optical response of metal nanoparticles and their associated plasmons is currently enabling many promising applications in areas as diverse as biosensing and photocatalysis. In this context, experiments based upon colloid synthesis and nanofabricated structures are assisted by numerical electromagnetic modeling, which supplies predictive simulations, but not the kind of physical intuition needed for exploration of new ideas, such as one finds when simple mathematical expressions can describe a problem...
September 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28929869/pharmacare-are-we-getting-the-right-medicines
#2
Gail Attara
Canada is the only country in the world with a national healthcare plan that does not include drug coverage. Coverage of necessary medications is a patchwork of inconsistent programs that does not always serve the very individuals it was created to help-those patients who need prescribed medicines. Our system needs radical, intuitive changes.
July 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929766/converting-vertical-vibration-of-anisotropic-ratchet-conveyors-into-horizontal-droplet-motion
#3
Yan Dong, Hal Holmes, Karl F Böhringer
An anisotropic ratchet conveyor is an asymmetric, periodic, micropatterned surface that propels droplets when vibrated with a sinusoidal signal at certain frequencies and amplitudes. For each input frequency, there is a threshold amplitude beyond which the droplet starts to move. In this paper, we study the parameters that initiate droplet motion and the relationship between the input frequency and threshold amplitude among droplets with different volume, density, viscosity and surface tension. Through this investigation we demonstrate how non-dimensionalization reveals consistent behavior for droplets of different volumes...
September 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28929305/auditory-display-for-fluorescence-guided-open-brain-tumor-surgery
#4
David Black, Horst K Hahn, Ron Kikinis, Karin Wårdell, Neda Haj-Hosseini
PURPOSE: Protoporphyrin (PpIX) fluorescence allows discrimination of tumor and normal brain tissue during neurosurgery. A handheld fluorescence (HHF) probe can be used for spectroscopic measurement of 5-ALA-induced PpIX to enable objective detection compared to visual evaluation of fluorescence. However, current technology requires that the surgeon either views the measured values on a screen or employs an assistant to verbally relay the values. An auditory feedback system was developed and evaluated for communicating measured fluorescence intensity values directly to the surgeon...
September 19, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28927724/empirical-evidence-for-the-relationship-between-cognitive-workload-and-attentional-reserve
#5
Kyle J Jaquess, Rodolphe J Gentili, Li-Chuan Lo, Hyuk Oh, Jing Zhang, Jeremy C Rietschel, Matthew W Miller, Ying Ying Tan, Bradley D Hatfield
While the concepts of cognitive workload and attentional reserve have been thought to have an inverse relationship for some time, such a relationship has never been empirically tested. This was the purpose of the present study. Aspects of the electroencephalogram were used to assess both cognitive workload and attentional reserve. Specifically, spectral measures of cortical activation were used to assess cognitive workload, while amplitudes of the event-related potential from the presentation of unattended "novel" sounds were used to assess attentional reserve...
September 16, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28927463/towards-precision-medicine-discovering-novel-gynecological-cancer-biomarkers-and-pathways-using-linked-data
#6
Alokkumar Jha, Yasar Khan, Muntazir Mehdi, Md Rezaul Karim, Qaiser Mehmood, Achille Zappa, Dietrich Rebholz-Schuhmann, Ratnesh Sahay
BACKGROUND: Next Generation Sequencing (NGS) is playing a key role in therapeutic decision making for the cancer prognosis and treatment. The NGS technologies are producing a massive amount of sequencing datasets. Often, these datasets are published from the isolated and different sequencing facilities. Consequently, the process of sharing and aggregating multisite sequencing datasets are thwarted by issues such as the need to discover relevant data from different sources, built scalable repositories, the automation of data linkage, the volume of the data, efficient querying mechanism, and information rich intuitive visualisation...
September 19, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28925979/a-new-quaternion-based-kalman-filter-for-real-time-attitude-estimation-using-the-two-step-geometrically-intuitive-correction-algorithm
#7
Kaiqiang Feng, Jie Li, Xiaoming Zhang, Chong Shen, Yu Bi, Tao Zheng, Jun Liu
In order to reduce the computational complexity, and improve the pitch/roll estimation accuracy of the low-cost attitude heading reference system (AHRS) under conditions of magnetic-distortion, a novel linear Kalman filter, suitable for nonlinear attitude estimation, is proposed in this paper. The new algorithm is the combination of two-step geometrically-intuitive correction (TGIC) and the Kalman filter. In the proposed algorithm, the sequential two-step geometrically-intuitive correction scheme is used to make the current estimation of pitch/roll immune to magnetic distortion...
September 19, 2017: Sensors
https://www.readbyqxmd.com/read/28924492/the-essentials-of-a-global-index-for-cognitive-function
#8
Joseph Mathew Antony, Ian Weaver, Matthew Rueffer, Najla Guthrie, Malkanthi Evans
Cognition is comprised of the faculties: perception, creativity, intuition, and ratiocination. Optimal levels of cognition are needed for independent functioning and balanced living. With an aging population that continues to grow, dietary supplements that tilt the balance towards maintenance of cognition are being marketed for vulnerable populations facing these challenges. Randomized clinical trials provide the causal inference necessary to define the efficacy of emerging nutraceuticals. Cognition testing, in particular, requires a battery of tests that encompass all brain regions involved in cognition so as to provide endpoints necessary for product validation...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28923473/virtual-surgery-for-patients-with-nasal-obstruction-use-of-computational-fluid-dynamics-mecomland-%C3%A2-digbody-%C3%A2-noseland-%C3%A2-to-document-objective-flow-parameters-and-optimise-surgical-results
#9
Manuel A Burgos, Maria Agustina Sevilla García, Enrique Sanmiguel Rojas, Carlos Del Pino, Carlos Fernández Velez, Francisco Piqueras, Francisco Esteban Ortega
INTRODUCTION: Computational fluid dynamics (CFD) is a mathematical tool to analyse airflow. We present a novel CFD software package to improve results following nasal surgery for obstruction. METHODS: A group of engineers in collaboration with otolaryngologists have developed a very intuitive CFD software package called MeComLand®, which uses the patient's cross-sectional (tomographic) images, thus showing in detail results originated by CFD such as airflow distributions, velocity profiles, pressure, or wall shear stress...
September 15, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28923159/the-extended-trust-hypothesis-single-attractor-self-contagion-in-day-to-day-changes-in-implicit-positive-affect-predicts-action-oriented-coping-and-psychological-symptoms
#10
Julius Kuhl, Olga Mitina, Sander L Koole
According to the extended trust hypothesis, the ability to cope with negative experiences is grounded in intuitive positive feelings about one's existence (Kuhl, Quirin, & Koole, 2015). In the present study, the authors empirically tested this hypothesis by examining the nonlinear dynamics in a series of day-to-day autoregressive functions of affective states taken from a 30-day daily mood diary study among 40 participants. A parameter (?) related to the asymptotic level of day-to-day changes in implicit positive mood predicted action orientation, a personality variable that relates to coping with negative affect, and psychological symptoms...
October 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/28923003/cleaning-by-clustering-methodology-for-addressing-data-quality-issues-in-biomedical-metadata
#11
Wei Hu, Amrapali Zaveri, Honglei Qiu, Michel Dumontier
BACKGROUND: The ability to efficiently search and filter datasets depends on access to high quality metadata. While most biomedical repositories require data submitters to provide a minimal set of metadata, some such as the Gene Expression Omnibus (GEO) allows users to specify additional metadata in the form of textual key-value pairs (e.g. sex: female). However, since there is no structured vocabulary to guide the submitter regarding the metadata terms to use, consequently, the 44,000,000+ key-value pairs in GEO suffer from numerous quality issues including redundancy, heterogeneity, inconsistency, and incompleteness...
September 18, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28922996/split-second-trustworthiness-detection-from-faces-in-an-economic-game
#12
Wim De Neys, Astrid Hopfensitz, Jean-François Bonnefon
Economic interactions often imply to gauge the trustworthiness of others. Recent studies showed that when making trust decisions in economic games, people have some accuracy in detecting trustworthiness from the facial features of unknown partners. Here we provide evidence that this face-based trustworthiness detection is a fast and intuitive process by testing its performance at split-second levels of exposure. Participants played a Trust game, in which they made decisions whether to trust another player based on their picture...
July 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28922387/epistemic-beliefs-role-in-promoting-misperceptions-and-conspiracist-ideation
#13
R Kelly Garrett, Brian E Weeks
Widespread misperceptions undermine citizens' decision-making ability. Conclusions based on falsehoods and conspiracy theories are by definition flawed. This article demonstrates that individuals' epistemic beliefs-beliefs about the nature of knowledge and how one comes to know-have important implications for perception accuracy. The present study uses a series of large, nationally representative surveys of the U.S. population to produce valid and reliable measures of three aspects of epistemic beliefs: reliance on intuition for factual beliefs (Faith in Intuition for facts), importance of consistency between empirical evidence and beliefs (Need for evidence), and conviction that "facts" are politically constructed (Truth is political)...
2017: PloS One
https://www.readbyqxmd.com/read/28922122/semi-automatic-generation-of-stream-surfaces-via-sketching
#14
Jun Tao, Chaoli Wang
We present a semi-automatic approach for stream surface generation. Our approach is based on the conjecture that good seeding curves can be inferred from a set of streamlines. Given a set of densely traced streamlines over the flow field, we design a sketch-based interface that allows users to describe their perceived flow patterns through drawing simple strokes directly on top of the streamline visualization results. Based on the 2D stroke, we identify a 3D seeding curve and generate a stream surface that captures the flow pattern of streamlines at the outermost layer...
September 15, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28921732/from-medico-administrative-databases-analysis-to-care-trajectories-analytics-an-example-with-the-french-snds
#15
Erwan Drezen, Thomas Guyet, André Happe
Medico-administrative data like SNDS (Système National de Données de Santé) are not collected initially for epidemiological purposes. Moreover, the data model and the tools proposed to SNDS users make their in-depth exploitation difficult. We propose a data model, called the ePEPS model, based on health care trajectories to provide a medical view of raw data. A data abstraction process enables the clinician to have an intuitive medical view of raw data and to design a study-specific view. This view is based on a generic model of care trajectory, i...
September 16, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28921444/polyester-based-nanoparticles-for-delivery-of-therapeutic-proteins
#16
Pedro Fonte, Flávia Sousa, Bruno Sarmento
Therapeutic proteins are widely used to treat severe conditions, such as oncologic and metabolic diseases, and also for vaccination. They are recognized for its high biopotency, but their hydrophilicity and high molecular weight make its transport through membranes difficult to achieve. They may also suffer in vivo structural instability caused by a proteolytic cleavage, turning them biological inactive. Polyester-based nanoparticles are useful tools to overcome such problems, and deliver therapeutic proteins in a controlled and localized manner, decreasing the number of administrations needed and enhancing the therapeutic outcome...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28919868/the-affective-core-of-the-self-a-neuro-archetypical-perspective-on-the-foundations-of-human-and-animal-subjectivity
#17
REVIEW
Antonio Alcaro, Stefano Carta, Jaak Panksepp
Psychologists usually considered the "Self" as an object of experience appearing when the individual perceives its existence within the conscious field. In accordance with such a view, the self-representing capacity of the human mind has been related to corticolimbic learning processes taking place within individual development. On the other hand, Carl Gustav Jung considered the Self as the core of our personality, in its conscious and unconscious aspects, as well as in its actual and potential forms. According to Jung, the Self originates from an inborn dynamic structure integrating the essential drives of our "brain-mind," and leading both to instinctual behavioral actions and to archetypal psychological experiences...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28919670/the-moral-insignificance-of-self-consciousness
#18
Joshua Shepherd
In this paper, I examine the claim that self-consciousness is highly morally significant, such that the fact that an entity is self-conscious generates strong moral reasons against harming or killing that entity. This claim is apparently very intuitive, but I argue it is false. I consider two ways to defend this claim: one indirect, the other direct. The best-known arguments relevant to self-consciousness's significance take the indirect route. I examine them and argue that (a) in various ways they depend on unwarranted assumptions about self-consciousness's functional significance, and (b) once these assumptions are undermined, motivation for these arguments dissipates...
June 2017: Eur J Philos
https://www.readbyqxmd.com/read/28919570/initial-clinical-experience-with-aview-a-clinical-computational-platform-for-intracranial-aneurysm-morphology-hemodynamics-and-treatment-management
#19
Jianping Xiang, Nicole Varble, Jason M Davies, Ansaar T Rai, Kenichi Kono, Shin-Ichiro Sugiyama, Mandy J Binning, Rabih G Tawk, Hoon Choi, Andrew J Ringer, Kenneth V Snyder, Elad I Levy, L Nelson Hopkins, Adnan H Siddiqui, Hui Meng
BACKGROUND: Intracranial aneurysm (IA) management is challenging. Clinicians often rely on varied and intuitively disparate ways of evaluating rupture risk that may only partially take into account complex hemodynamic and morphologic factors. We developed a prototype of a clinically-oriented, streamlined, computational platform, AView, for rapid assessment of hemodynamics and morphometrics in clinical settings. To show the potential clinical utility of AView, we report our initial multicenter experience highlighting the possible advantages of morphologic and hemodynamic analysis of IAs...
September 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28919460/a-likelihood-based-approach-to-p-value-interpretation-provided-a-novel-plausible-and-clinically-useful-research-study-metric
#20
Nicholas G Adams, Gerard O'Reilly
OBJECTIVES: Interpretation of clinical research findings using the paradigm of null hypothesis significance testing has a number of limitations. These include arbitrary dichotomization of results, lack of incorporation of study power and prior probability, and the confusing use of conditional probability. This study aimed to describe a novel method of P-value interpretation that would address these limitations. STUDY SETTING AND DESIGN: Published clinical research was re-interpreted using the delta likelihood ratio...
September 14, 2017: Journal of Clinical Epidemiology
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