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https://www.readbyqxmd.com/read/22977006/priming-with-synthetic-oligonucleotides-attenuates-pressure-overload-induced-inflammation-and-cardiac-hypertrophy-in-mice
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Markus Velten, Georg D Duerr, Thilo Pessies, Julia Schild, Ralph Lohner, Jan Mersmann, Oliver Dewald, Kai Zacharowski, Sven Klaschik, Tobias Hilbert, Andreas Hoeft, Georg Baumgarten, Rainer Meyer, Olaf Boehm, Pascal Knuefermann
AIMS: Inflammation and Toll-like receptor (TLR) signalling have been linked to the development of cardiac hypertrophy following transverse aortic constriction (TAC). In the present study, we investigated whether pre-treatment with the synthetic TLR9 ligands 1668-thioate or 1612-thioate modulates the progression of TAC-induced cardiac inflammation and hypertrophy. METHODS AND RESULTS: C57BL/6N-mice were pre-treated with 1668-thioate, 1612-thioate (0.25 nmol/g, i...
December 1, 2012: Cardiovascular Research
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