Stephan Ehrmann, François Barbier, Julien Demiselle, Jean-Pierre Quenot, Jean-Etienne Herbrecht, Damien Roux, Jean-Claude Lacherade, Mickaël Landais, Philippe Seguin, David Schnell, Anne Veinstein, Philippe Gouin, Sigismond Lasocki, Qin Lu, Gaëtan Beduneau, Martine Ferrandiere, Gaëtan Plantefève, Claire Dahyot-Fizelier, Nader Chebib, Emmanuelle Mercier, Nathalie Heuzé-Vourc'h, Renaud Respaud, Nicolas Gregoire, Denis Garot, Mai-Anh Nay, Ferhat Meziani, Pascal Andreu, Raphaël Clere-Jehl, Noémie Zucman, Marie-Ange Azaïs, Marjorie Saint-Martin, Charlotte Salmon Gandonnière, Dalila Benzekri, Hamid Merdji, Elsa Tavernier
BACKGROUND: Whether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear. METHODS: In this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critically ill adults who had been undergoing invasive mechanical ventilation for at least 72 hours to receive inhaled amikacin at a dose of 20 mg per kilogram of ideal body weight once daily or to receive placebo for 3 days...
November 30, 2023: New England Journal of Medicine