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Venous thromboprophylaxis

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https://www.readbyqxmd.com/read/29682981/incidence-of-and-risk-factors-for-venous-thromboembolism-after-foot-and-ankle-surgery
#1
Samuel R Huntley, Eildar Abyar, Eva J Lehtonen, Harshadkumar A Patel, Sameer Naranje, Ashish Shah
BACKGROUND: Venous thromboembolism (VTE) is a rare but potentially lethal complication after orthopaedic foot and ankle surgery. The true incidence of VTE after orthopaedic foot and ankle surgery stratified by specific procedure has yet to be examined. The purpose of this study is to report the incidence of and identify risk factors for VTE in a large sample of patients receiving orthopaedic foot and ankle surgery. METHODS: In this study, we retrospectively analyzed data from the National Surgical Quality Improvement Program 2006 to 2015 data files...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29660351/association-of-low-hemoglobin-with-symptomatic-venous-thromboembolism-in-acutely-ill-hospitalized-medical-patients-an-apex-trial-substudy
#2
Gerald Chi, C Michael Gibson, Adrian F Hernandez, Russell D Hull, Syed Hassan A Kazmi, Ahmed Younes, Sargun S Walia, Anmol Pitliya, Amandeep Singh, Farima Kahe, Arzu Kalayci, Tarek Nafee, Mathieu Kerneis, Fahad AlKhalfan, Alexander T Cohen, Robert A Harrington, Samuel Z Goldhaber
BACKGROUND: Anemia is a common finding and independent predictor for adverse outcomes in hospitalized patients with medical illness. It remains unclear whether anemia is a risk factor for venous thromboembolism and whether the presence of anemia can refine risk assessment for prediction of venous thromboembolism, thereby adding incremental utility to a validated model. METHODS: In the APEX trial, 7,513 hospitalized medical patients were randomized to receive either betrixaban or standard-of-care enoxaparin for thromboprophylaxis...
April 13, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29653390/fondaparinux-versus-nadroparin-for-thromboprophylaxis-following-minimally-invasive-esophagectomy-a-randomized-controlled-trial
#3
Jieqiong Song, Lizhen Xuan, Wei Wu, Yaxing Shen, Lijie Tan, Ming Zhong
BACKGROUND: The methodology of thromboprophylaxis post minimally invasive esophagectomy (MIE) is unclear. Thus, we compared the efficacy and safety of fondaparinux and nadroparin on the prophylaxis of venous thromboembolism (VTE) after MIE. MATERIALS AND METHODS: We conducted a randomized, double-blind, treatment-controlled study. Consecutive patients undergoing MIE randomly received a single dose of either nadroparin 2850 AxaIU (Group H) or fondaparinux 2.5 mg (Group F) daily...
April 4, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29651665/evaluation-and-management-of-thromboprophylaxis-in-moroccan-hospitals-at-national-level-the-avail-mona-study
#4
Z Tazi Mezalek, C Nejjari, L Essadouni, M Samkaoui, K Serraj, W Ammouri, N Kanjaa, Z Belkhadir, B Housni, M Awab, M Faroudy, W Bono, S Kabbaj, M Akkaoui, M Barakat, R Rifai, H Charaf, A Aziz, Y Elachhab, A Azzouzi
Venous thromboembolism (VTE) is a common clinical problem that is associated with substantial morbidity and mortality. The aim of this study was to describe the clinical practices in VTE prophylaxis in university and peripheral hospitals in Morocco. This is a national, cross-sectional, multicenter, observational study assessing the management of the VTE risk in selected Moroccan hospitals (four university and three peripheral). The thromboembolic risk of the selected patients was assessed according to the American College of Chest Physicians (ACCP) guidelines (2008)...
April 12, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29644835/risk-assessment-as-a-guide-for-the-prevention-of-cancer-associated-thromboembolism
#5
Ahmed Al-Ogaili, Harry E Fuentes, Alfonso J Tafur, Joseph Caprini
Venous thromboembolism (VTE) is a major source of morbidity and mortality among patients diagnosed with cancer. In addition to an increased risk of VTE, patients with cancer are at higher risk of bleeding while receiving therapeutic anticoagulation. Aggressive and targeted thromboprophylaxis is a crucial practice to avoid the dreaded complications of VTE. Risk assessment models (RAM) are tools developed to identify high-risk patients in whom thromboprophylaxis is beneficial. This review describes the most validated VTE RAMs in patients with cancer...
April 11, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29628468/induction-of-anti-pf4-heparin-antibodies-after-arthroplasty-for-rheumatic-diseases
#6
Kiyoshi Migita, Tomoyuki Asano, Shuzo Sato, Satoru Motokawa
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. These pathogenic antibodies against PF4/heparin bind and activate cellular FcγRIIa on platelets to induce a hypercoagulable state culminating in thrombosis. Recent studies indicate several conditions, including joint surgery, induce spontaneous HIT, which can occur without exposure to heparin. To determine the real-world evidences concerning the incidences of venous thromboembolism (VTE) after total joint arthroplasty for rheumatic disease, we conducted a multicenter cohort study (J-PSVT) designed to document the VTE and seroconversion rates of anti-PF4/heparin antibody in 34 Japanese National hospital organization (NHO) hospitals...
April 7, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29628414/catheter-related-venous-thrombosis-in-hospitalized-pediatric-patients-with-inflammatory-bowel-disease-incidence-characteristics-and-role-of-anticoagulant-thromboprophylaxis-with-enoxaparin
#7
Carrie E Diamond, Carole Hennessey, Jennifer Meldau, Christine J Guelcher, Michael F Guerrera, Laurie S Conklin, Karun V Sharma, Yaser A Diab
OBJECTIVE: To describe the incidence and characteristics of central venous catheter (CVC)-related thrombosis in hospitalized pediatric patients with active inflammatory bowel disease (IBD) and report the potential usefulness of anticoagulant thromboprophylaxis (AT). STUDY DESIGN: We conducted a retrospective study of patients who were admitted to our children's hospital in the last 2 years with active IBD and required a CVC and identified all patients with an objectively confirmed symptomatic CVC-related thrombosis...
April 5, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29620660/nurses-objective-knowledge-regarding-venous-thromboembolism-prophylaxis-a-national-survey-study
#8
Yu-Fen Ma, Yuan Xu, Ya-Ping Chen, Xiao-Jie Wang, Hai-Bo Deng, Yu He, Xin-Juan Wu
Venous thromboembolism (VTE) is a common vascular disorder with high mortality and morbidity. Clinical nurses are a pivotal group that can serve as first-line health care providers. Lack of knowledge about VTE is an important barrier to effective nursing performance. This study aimed to determine nurses' knowledge of VTE prophylaxis through a nationwide survey across China, to understand gaps between current knowledge, and guidelines, and to help improve clinical nursing.The survey included 5 topics with 68 items on VTE, including basic knowledge, risk assessment, basic prophylaxis, physical prophylaxis, and pharmacological prophylaxis...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29618152/altered-plasma-clot-properties-and-trauma-related-venous-thromboembolism-despite-thromboprophylaxis
#9
Sarah Goldman, Paulina Frączek, Krzysztof Szklanny, Elżbieta Papuga-Szela, Andrzej Stanisz, Anetta Undas
BACKGROUND:  Prothrombotic clot phenotype may characterize patients developing deep vein thrombosis (DVT) despite pharmacological thromboprophylaxis. We studied the role of fibrin clot properties and its potential determinants in individuals who experienced DVT after lower limb injury. METHODS:  In a case-control study, we assessed 50 patients who developed DVT despite prophylactic use of low-molecular-weight heparins (the failed thromboprophylaxis group) after a lower limb injury, and three age- and sex-matched control groups, 50 patients each: (1) patients with trauma-related DVT without prior thromboprophylaxis; (2) individuals with unprovoked DVT; (3) patients without history of DVT (the no-DVT controls)...
April 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29613956/optimal-timing-of-initiation-of-thromboprophylaxis-in-spine-trauma-managed-operatively-a-nationwide-propensity-matched-analysis-of-trauma-quality-improvement-program
#10
Muhammad Zeeshan, Muhammad Khan, Terence O'Keeffe, Nina Pollack, Mohammad Hamidi, Narong Kulvatunyou, Joseph V Sakran, Lynn Gries, Bellal Joseph
INTRODUCTION: Patients with spinal trauma are at high-risk for venous-thromboembolism(VTE). Guidelines recommend prophylactic anticoagulation but they are unclear on timing of initiation of thromboprophylaxis. The aim of our study was to assess the impact of early vs late initiation of venous thromboprophylaxis in patients with spinal trauma who underwent operative intervention. METHODS: We performed a 2-year (2013-14) review of patients with isolated spine trauma (S-AIS≥3 and no other injury in another body region with AIS>2) who underwent operative intervention and received thromboprophylaxis post-operatively...
April 2, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29602141/is-thromboprophylaxis-cost-effective-in-ovarian-hyperstimulation-syndrome-a-systematic-review-and-cost-analysis
#11
REVIEW
Kelly Comerford Wormer, Ayesha A Jangda, Farah A El Sayed, Katherine I Stewart, Sunni L Mumford, James H Segars
BACKGROUND: The majority of serious thromboembolic events occurring in assisted reproductive technologies (ART) are in women with ovarian hyperstimulation syndrome (OHSS). OBJECTIVES: The purpose of this study was to present a thorough review and cost analysis regarding the use of venous thromboembolism (VTE) prophylaxis in OHSS to inform clinical management. DATA SOURCES: Databases used were Pubmed and Embase, in addition to checking reference lists of retrieved articles (inception to November 2017)...
March 19, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29594815/has-time-come-for-the-use-of-direct-oral-anticoagulants-in-the-extended-prophylaxis-of-venous-thromboembolism-in-acutely-ill-medical-patients-no
#12
Francesco Marongiu, Doris Barcellona
Acutely ill hospitalized medical patients are at high risk of venous thromboembolism (VTE). Although thromboprophylaxis in these patients is recommended since 2004 by the American College of Chest Physicians, it is widely underused. The doubt as to whether or not to treat patients at high VTE risk after hospital discharge came from the knowledge that this risk may persist after the hospital admission period. Two meta-analyses comparing extended- versus short-duration prophylaxis are published. The results demonstrate an unfavorable balance between VTE prevention and incidence of major bleeding in patients assigned to extended-duration thromboprophylaxis...
March 28, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29592538/enoxaparin-dosing-at-extremes-of-weight-literature-review-and-dosing-recommendations
#13
Jamie Sebaaly, Kelly Covert
OBJECTIVE: To review the literature on both thromboprophylaxis and treatment of venous thromboembolism (VTE) with enoxaparin in low- and high-body-weight patients and to make dosing and monitoring recommendations in these patient populations. DATA SOURCES: A search using PubMed was conducted (1995 to January 2018) using the following key words: enoxaparin, body weight, AND thromboprophylaxis, or AND treatment. Additional references were identified from a review of citations...
March 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29590720/implementation-of-venous-thromboembolism-prophylaxis-guidelines-in-clinical-practice-a-retrospective-study-in-two-croatian-hospitals
#14
Srećko Marušić, Aleksandar Knežević, Vesna Bačić Vrca, Ivana Marinović, Julija Bačić, Paulo Roque Obreli Neto, Daniela Amidžić Klarić, Dijaneta Diklić
The aim of this study was to evaluate the implementation of the 9th edition of the American College of Chest Physicians (ACCP9) guidelines for prevention of venous thromboembolism in nonsurgical patients in clinical practice in one university and one general Croatian hospital. A retrospective study was conducted at Zadar General Hospital from Zadar and Dubrava University Hospital from Zagreb. Medical charts of all patients admitted to Medical Departments in two periods, before and after implementation of the ACCP9 guidelines, were analyzed...
December 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29590126/risk-of-venous-thromboembolism-during-rehabilitation-of-patients-with-spinal-cord-injury
#15
Sabine Eichinger, Lisbeth Eischer, Hana Sinkovec, Gabriela Wittgruber, Ludwig Traby, Michael Kammer, Paul A Kyrle, Oskar Steinbrecher, Herbert Kaloud, Victoria Kyrle, Hartwig Moser, Renate Wildburger
BACKGROUND: Patients with spinal cord injury (SCI) are at risk of thrombosis and bleeding. Data on the risks during rehabilitation are inconsistent, and thromboprophylactic strategies are heterogeneous. We aimed to evaluate the thrombotic risk and bleeding events of SCI patients during rehabilitation. METHODS: We retrospectively collected hospital record data of 263 consecutive SCI patients admitted at a rehabilitation clinic. 78 patients with acute venous thromboembolism (VTE) at the primary center, without acute trauma or lower extremity paresis, less than one month rehabilitation, or reasons for long-term therapeutic anticoagulation, were excluded...
2018: PloS One
https://www.readbyqxmd.com/read/29588512/multivariable-clinical-genetic-risk-model-for-predicting-venous-thromboembolic-events-in-patients-with-cancer
#16
Andrés J Muñoz Martín, Israel Ortega, Carme Font, Vanesa Pachón, Victoria Castellón, Virginia Martínez-Marín, Mercedes Salgado, Eva Martínez, Julia Calzas, Ana Rupérez, Juan C Souto, Miguel Martín, Eduardo Salas, Jose M Soria
BACKGROUND: Venous thromboembolism (VTE) is a leading cause of death among patients with cancer. Outpatients with cancer should be periodically assessed for VTE risk, for which the Khorana score is commonly recommended. However, it has been questioned whether this tool is sufficiently accurate at identifying patients who should receive thromboprophylaxis. The present work proposes a new index, TiC-Onco risk score to be calculated at the time of diagnosis of cancer, that examines patients' clinical and genetic risk factors for thrombosis...
March 28, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29580885/prophylaxis-of-venous-thromboembolism-in-geriatric-settings-a-cluster-randomized-multicomponent-interventional-trial
#17
Jean Paul Rwabihama, Etienne Audureau, Marie Laurent, Lalaina Rakotoarisoa, Marc Jegou, Sofiane Saddedine, Sébastien Krypciak, Stéphane Herbaud, Hind Benzengli, Lauriane Segaux, Esther Guery, Gabin Ambime, Marie-Thérèse Rabus, Jean-Guy Perilliat, Jean-Philippe David, Elena Paillaud
OBJECTIVES: To evaluate the efficacy of an intervention on the practice of venous thromboembolism prevention. DESIGN: A multicenter, prospective, controlled, cluster-randomized, multifaceted intervention trial consisting of educational lectures, posters, and pocket cards reminding physicians of the guidelines for thromboprophylaxis use. SETTINGS: Twelve geriatric departments with 1861 beds total, of which 202, 803, and 856 in acute care, postacute care, and long-term care wards, respectively...
March 23, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29575637/effect-of-rosuvastatin-on-risk-markers-for-venous-thromboembolism-in-cancer
#18
S Ades, D Douce, C E Holmes, S Cory, S Prior, S Butenas, P Callas, M Cushman
BACKGROUND: Statin therapy is associated with lower risk of venous thromboembolism (VTE), but has not been prospectively evaluated in patients with advanced cancer. OBJECTIVES: We determined if statin administration in this high-risk population reduces VTE risk, based on established and emerging biomarkers. PATIENTS/METHODS: This double-blind crossover randomized controlled trial among patients with advanced cancer receiving systemic therapy allocated participants to rosuvastatin 20mg daily, or placebo for 3-4 weeks prior to crossover to the alternative therapy with a 3-5 week washout...
March 25, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29573720/postpartum-blood-transfusion-and-hemorrhage-as-independent-risk-factors-for-venous-thromboembolism
#19
L Thurn, A Wikman, P G Lindqvist
INTRODUCTION: Profuse postpartum hemorrhage (PPH) and red blood cell (RBC) transfusion have been suggested to be associated with venous thromboembolic events (VTE). However, it is not fully clear if they are independent major risk factors. METHODS: Women who gave birth in the Stockholm area between 1999 and 2002 were those studied, i.e., before the implementation of guidelines for thromboprophylaxis in pregnancy. In this population-based cohort study the Swedish Medical Birth Registry was linked to the National Discharge Registry and to the transfusion database...
March 10, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29558778/direct-oral-anticoagulants-and-the-paradigm-shift-in-the-management-of-venous-thromboembolism
#20
Hui Yin Lim, Harshal Nandurkar, Prahlad Ho
The advent of direct oral anticoagulants (DOACs) has revolutionized anticoagulation management in both stroke prevention and venous thromboembolism (VTE) treatment/prevention. Clinical trials and secondary real-world data have shown that DOACs have similar efficacy and, in some cases, improved bleeding safety profiles compared with vitamin K antagonists. Together with benefits of patient convenience, this has shifted the risk-benefit ratio toward long-term anticoagulation. However, current VTE risk assessment models are based on vitamin K antagonists and do not take into account the new paradigm of DOACs...
March 20, 2018: Seminars in Thrombosis and Hemostasis
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