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Iv paracetamol, acetaminophen

Ewan D McNicol, McKenzie C Ferguson, Simon Haroutounian, Daniel B Carr, Roman Schumann
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 10, 2011. Paracetamol (acetaminophen) is the most commonly prescribed analgesic for the treatment of acute pain. It may be administered orally, rectally, or intravenously. The efficacy and safety of intravenous (IV) formulations of paracetamol, IV paracetamol, and IV propacetamol (a prodrug that is metabolized to paracetamol), compared with placebo and other analgesics, is unclear. OBJECTIVES: To assess the efficacy and safety of IV formulations of paracetamol for the treatment of postoperative pain in both adults and children...
2016: Cochrane Database of Systematic Reviews
Elizabeth Chiam, Laurence Weinberg, Michael Bailey, Larry McNicol, Rinaldo Bellomo
AIM: The haemodynamic effects of intravenous paracetamol have not been systematically investigated. We compared the physiological effects of intravenous mannitol-containing paracetamol, and an equivalent dosage of mannitol, and normal saline 0.9% in healthy volunteers. METHODS: We performed a blinded, triple crossover, randomized trial of 24 adult healthy volunteers. Participants received i.v. paracetamol (1 g paracetamol +3.91 g mannitol 100 ml(-1) ), i.v. mannitol (3...
April 2016: British Journal of Clinical Pharmacology
Sarah F Cook, Jessica K Roberts, Samira Samiee-Zafarghandy, Chris Stockmann, Amber D King, Nina Deutsch, Elaine F Williams, Karel Allegaert, Diana G Wilkins, Catherine M T Sherwin, John N van den Anker
OBJECTIVES: The aims of this study were to develop a population pharmacokinetic model for intravenous paracetamol in preterm and term neonates and to assess the generalizability of the model by testing its predictive performance in an external dataset. METHODS: Nonlinear mixed-effects models were constructed from paracetamol concentration-time data in NONMEM 7.2. Potential covariates included body weight, gestational age, postnatal age, postmenstrual age, sex, race, total bilirubin, and estimated glomerular filtration rate...
January 2016: Clinical Pharmacokinetics
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: Newborn infants have the ability to experience pain. Newborns treated in neonatal intensive care units are exposed to numerous painful procedures. Healthy newborns are exposed to pain if the birth process consists of assisted vaginal birth by vacuum extraction or by forceps and during blood sampling for newborn screening tests. OBJECTIVES: Primary objectiveTo determine the efficacy and safety of paracetamol for the prevention or treatment of procedural/postoperative pain or pain associated with clinical conditions in neonates...
2015: Cochrane Database of Systematic Reviews
M Upadya, S H Pushpavathi, Kaushik Rao Seetharam
BACKGROUND: Nonsteroidal anti-inflammatory drugs used for postoperative analgesia have considerable adverse effects, with paracetamol having a different mechanism of action, superior side effect profile and availability in intravenous (IV) form, this study was conducted to compare intra-peritoneal bupivacaine with IV paracetamol for postoperative analgesia following laparoscopic cholecystectomy. AIM: The aim was to compare the efficacy of intra-peritoneal administration of bupivacaine 0...
January 2015: Anesthesia, Essays and Researches
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA). A PDA can be treated surgically or medically with one of two prostaglandin inhibitors, indomethacin or ibuprofen. Case reports suggest that paracetamol may be an alternative for the closure of a PDA. Concerns have been raised that in neonatal mice paracetamol may cause adverse effects on the developing brain, and an association between prenatal exposure to paracetamol and later development of autism or autism spectrum disorder has been reported...
2015: Cochrane Database of Systematic Reviews
Michael J Gonzalez, Jorge R Miranda-Massari, Miguel J Berdiel, Jorge Duconge, Joshua L Rodríguez-López, Ron Hunninghake, Vicente J Cobas-Rosario
The Chikungunya (CHIKV) fever is a viral disease produced by a single-stranded RNA Alphavirus from the Togaviridae genus. Its transmission occurs only through mosquito vectors, principally Aedes aegypti. It requires a human-mosquito-human transmission cycle. It is associated with severe arthritis/arthralgias, myalgias, high fever, headache, and maculopapular rash. Joint ache appears to be symmetrical. The virus has an incubation period of 2 to 7 days, where the high fever is typically presented. It is followed by arthralgias and myalgias, and rashes, which last for 3 to 5 days...
2014: Journal of Orthomolecular Medicine: Official Journal of the Academy of Orthomolecular Medicine
E Ericsson, M Brattwall, S Lundeberg
BACKGROUND: Surgery of the tonsils often causes severe pain lasting for many days as been shown by data from the National Tonsil Surgery Register in Sweden. Tonsillotomy is associated with fewer readmissions due to bleeding, number of days requiring analgesics and health care contacts due to pain compared to tonsillectomy. The register data demonstrate the necessity of better-evidenced based pain treatment guidelines for tonsil-surgery. OBJECTIVES: To develop evidenced based pain treatment guidelines for tonsil-surgery in Sweden...
April 2015: International Journal of Pediatric Otorhinolaryngology
Jennifer Le, Mark A Gales, Barry J Gales
OBJECTIVE: To evaluate the literature describing acetaminophen use in treatment of patent ductus arteriosus (PDA). DATA SOURCES: Searches were conducted in MEDLINE with full text (EBSCOhost; 1946 to September 2014) using the search terms acetaminophen, paracetamol, and patent ductus arteriosus. The references of identified articles were reviewed to identify other relevant articles. STUDY SELECTION AND DATA EXTRACTION: Human clinical trials and case reports limited to the English language were reviewed...
February 2015: Annals of Pharmacotherapy
Karel Allegaert, Klaus T Olkkola, Katie H Owens, Marc Van de Velde, Monique M de Maat, Brian J Anderson
BACKGROUND: Pharmacokinetic estimates for intravenous paracetamol in individual adult cohorts are different to a certain extent, and understanding the covariates of these differences may guide dose individualization. In order to assess covariate effects of intravenous paracetamol disposition in adults, pharmacokinetic data on discrete studies were pooled. METHODS: This pooled analysis was based on 7 studies, resulting in 2755 time-concentration observations in 189 adults (mean age 46 SD 23 years; weight 73 SD 13 kg) given intravenous paracetamol...
2014: BMC Anesthesiology
April N Smith, Vie C Hoefling
OBJECTIVE: This study aimed to determine if intravenous acetaminophen [paracetamol] (IV APAP) could decrease visual analog pain scores (VAS), opioid exposure and subsequent opioid related adverse effects (nausea, vomiting, constipation) in spinal surgery patients. METHODS: Thirty four spinal surgery patients to date have received IV APAP since its addition to the formulary at our institution. The electronic medical record was accessed on all patients who received at least one dose pre or post operatively to collect postoperative opioid consumption (in morphine equivalents), number of antiemetic and laxative doses, use of naloxone, and VAS pain scores from arrival to surgical unit through postop day two...
July 2014: Pharmacy Practice
Miriam G Mooij, Esther van Duijn, Catherijne A J Knibbe, Albert D Windhorst, N Harry Hendrikse, Wouter H J Vaes, Edwin Spaans, Babs O Fabriek, Hugo Sandman, Dimitri Grossouw, Lidwien M Hanff, Paul J J M Janssen, Birgit C P Koch, Dick Tibboel, Saskia N de Wildt
BACKGROUND: Pediatric drug development is hampered by practical, ethical, and scientific challenges. Microdosing is a promising new method to obtain pharmacokinetic data in children with minimal burden and minimal risk. The use of a labeled oral microdose offers the added benefit to study intestinal and hepatic drug disposition in children already receiving an intravenous therapeutic drug dose for clinical reasons. OBJECTIVE: The objective of this study was to present pilot data of an oral [(14)C]paracetamol [acetaminophen (AAP)] microdosing study as proof of concept to study developmental pharmacokinetics in children...
November 2014: Clinical Pharmacokinetics
W Stephen Waring
Paracetamol (acetaminophen) overdose remains the leading cause of death or transplantation due to acute liver failure in many parts of the world. Acetylcysteine has long been recognized as an effective antidote, via oral or intravenous administration, minimizing the risk and severity of acute liver injury if administered sufficiently early after a paracetamol overdose. Despite this, its mechanisms of action remain obscure, and there is uncertainty regarding the optimal dose and duration of treatment. The intravenous infusion protocol was originally developed as a three-step loading regimen; it causes very high early peak plasma concentrations of acetylcysteine whereas the later maintenance infusion is associated with much lower concentrations...
December 2012: Therapeutic Advances in Drug Safety
Aiwu Zhang, Tao Jiang, Yifeng Luo, Zhenyang Zheng, Xiaolei Shi, Zijian Xiao, Yannan Fang
BACKGROUND: Triptans are a family of selective serotonin (5-HT1B/1D) receptor agonists that are widely used to treat acute migraine attacks. Their efficacy is limited by side effects and the gastrointestinal manifestations of migraine. AIM: To compare the efficacy of a single intravenous administration of propacetamol, a prodrug of paracetamol (acetaminophen) with a single dose of oral rizatriptan in treating acute migraine attacks. METHODS: Patients were selected from those who presented to the emergency room with a diagnosed migraine attack and who had not previously taken any analgesics...
September 2014: European Journal of Internal Medicine
Ali Akdogan, Ahmet Eroglu
OBJECTIVE: Comparison of dexketoprofen and paracetamol added to the lidocaine in Regional Intravenous Anesthesia in terms of hemodynamic effects, motor and sensorial block onset times, intraoperative VAS values, and analgesia requirements. METHOD: The files of 73 patients between 18 and 65 years old in the ASA I-II risk group who underwent hand and forearm surgery were analyzed and 60 patients were included in the study. Patients were divided into 3 groups: Group D (n = 20), 3 mg/kg 2% lidocaine and 50 mg/2 mL dexketoprofen trometamol; Group P (n = 20), 3 mg/kg 2% lidocaine and 3 mg/kg paracetamol; Group K (n = 20), 3 mg/kg 2% lidocaine...
2014: BioMed Research International
Zrinka Oreskovic, Goran Bicanic, Pero Hrabac, Branko Tripkovic, Domagoj Delimar
INTRODUCTION: Metamizole use has been limited because of its risk of agranulocytosis. However, more recent literature seems to support its safety. This prospective, randomised, double-blind study was conducted to compare the analgesic effects of intravenous metamizole or intravenous paracetamol in combination with morphine PCA during the first 24 h following total hip arthroplasty. MATERIALS AND METHODS: One hundred ten consecutive patients were selected for study...
May 2014: Archives of Orthopaedic and Trauma Surgery
Sasmita Biswal, Swayam Sourav Sahoo
BACKGROUND: Though any drug can be a potential cause of such hypersensitivity reactions, paracetamol, an over-the-counter drug used extensively as an analgesic and antipyretic agent, is considered to be relatively safe, with hepatotoxicity as a major adverse effect only in large doses. MATERIALS AND METHODS: We report an instance of a severe case of SJS-TEN overlap syndrome in a 12-year-old girl, induced by three over-the-counter doses of 500 mg of paracetamol taken at 8-hour intervals for fever...
August 2014: International Journal of Dermatology
C van Ganzewinkel, L Derijks, K J S Anand, R A van Lingen, C Neef, B W Kramer, P Andriessen
AIM: The therapeutic options available to treat neonatal pain are limited, and one alternative for nonopioid systemic treatment is paracetamol. However, pharmacokinetic data from prolonged administration of intravenous paracetamol in neonates are limited. The aim of this study was to present pharmacokinetics after multiple dose of intravenous paracetamol in very preterm infants of <32 weeks' gestation. METHODS: Fifteen very preterm infants received five, six-hourly doses of intravenous paracetamol (7...
June 2014: Acta Paediatrica
Scott B Groudine, Howard S Smith, Duane Ellsworth
SUMMARY The need to safely treat the postoperative pain of patients is apparent. Opioids, although effective, have multiple morbidities associated with their use. A multimodal approach to postoperative pain management can serve to minimize the undesirable effects of opioids. Intravenous acetaminophen (paracetamol) has recently become available in the USA where many practitioners are not familiar with this drug. This article reviews the history, pharmacology and clinical uses of intravenous acetaminophen in the treatment of perioperative pain...
September 2012: Pain Management
Evangelos J Giamarellos-Bourboulis, Aikaterini Spyridaki, Athina Savva, Marianna Georgitsi, Thomas Tsaganos, Maria Mouktaroudi, Maria Raftogiannis, Anastasia Antonopoulou, Vassilios Papaziogas, Fotini Baziaka, Kalliopi Sereti, Petros Christopoulos, Androniki Marioli, Theodora Kanni, Panagiota Maravitsa, Ilianna Pantelidou, Konstantinos Leventogiannis, Panagiotis Tsiaoussis, Korina Lymberopoulou, Ioannis M Koutelidakis
One prospective, open-label, non-randomized study was conducted in 100 patients to define the antipyretic and analgesic effect of a new intravenous formulation of 1 g of paracetamol; 71 received paracetamol for the management of fever and 29 received paracetamol for pain relief after abdominal surgery or for neoplastic pain. Serial follow-up measurements of core temperature and of pain intensity were done for 6 h. Additional rescue medications were recorded for 5 days. Blood was sampled for the measurement of free paracetamol (APAP) and of glucuronide-APAP and N-sulfate-APAP by an HPLC assay...
2014: Journal of Pharmacological Sciences
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