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https://www.readbyqxmd.com/read/29334338/at-home-genital-nerve-stimulation-for-individuals-with-sci-and-neurogenic-detrusor-overactivity-a-pilot-feasibility-study
#1
Dennis J Bourbeau, Kenneth J Gustafson, Steven W Brose
OBJECTIVE: Neurogenic bladder dysfunction, including neurogenic detrusor overactivity (NDO) is one of the most clinically significant problems for persons with spinal cord injury (SCI), affecting health and quality of life. Genital nerve stimulation (GNS) can acutely inhibit NDO-related reflex bladder contractions and increase bladder capacity. However, it is unknown if GNS can improve urinary continence or help meet individuals' bladder management goals during sustained use, which is required for GNS to be clinically effective...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29333618/age-associated-urethral-dysfunction-in-urethane-anesthetized-rats
#2
Ryu Kimura, Minoru Miyazato, Asuka Ashikari, Takuma Oshiro, Seiichi Saito
AIMS: We aimed to investigate the age-associated changes in movement coordination between the urinary bladder and the urethra in rats. METHODS: A total of 17 female Sprague-Dawley rats were used. The rats were divided into young (3 months old) and middle-aged (12-15 months old) groups. In both groups, isovolumetric cystometry and urethral perfusion pressure (UPP) measurements were performed under urethane anesthesia. After the rhythmic bladder contractions stabilized, L-arginine, a nitric oxide (NO) substrate (100 mg/kg), was administered intravenously in both groups...
January 15, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29332252/a-review-of-the-impact-of-pregnancy-and-childbirth-on-pelvic-floor-function-as-assessed-by-objective-measurement-techniques
#3
REVIEW
Hans Van Geelen, Donald Ostergard, Peter Sand
The objective of this narrative review is to study the impact of pregnancy and childbirth on pelvic floor function as assessed by objective measurement techniques with quantitative data carried out during pregnancy and after childbirth. A literature search in MEDLINE and relevant and up-to-date journals from 1960 until April 2017 was performed for articles dealing with the impact of pregnancy and childbirth on pelvic floor function as assessed by objective measurement methods. Only studies describing objective measurement techniques...
January 13, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29324966/advanced-practice-nursing-in-pediatric-urology-experience-report-in-the-federal-district
#4
Bruna Marcela Lima de Souza, Cristiane Feitosa Salviano, Gisele Martins
OBJECTIVE: To describe the creation and implementation of the extension program Advanced Practice Nursing in Pediatric Urology, developed in the outpatient clinic of a teaching hospital in the Federal District. METHOD: This is an experience report regarding the implementation of an outpatient service aimed at children and adolescents with symptoms of bladder and bowel dysfunction. RESULTS: Because it is an extension program linked to the university, it follows a different model of care, valuing empowerment, informed and shared decision making, which results in a stronger bond between patients, family and the Pediatric Urology nursing team...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29322636/lower-urinary-tract-dysfunction-in-pediatric-patients-after-ureteroneocystostomy-due-to-vesicoureteral-reflux-long-term-follow-up
#5
Kaya Horasanli, Göksel Bayar, Huseyin Acinikli, Cemil Kutsal, Sinan L Kirecci, Ayhan Dalkilic
OBJECTIVE: The aim of the present study was to evaluate long-term lower urinary tract dysfunction (LUTD) in pediatric patients who underwent ureteroneocystostomy due to vesicoureteral reflux. METHODS: The present retrospective study was performed on 61 patients. Patients were divided into 3 groups: Group 1 (n = 26), did not have LUTD; Group 2 (n = 23), had LUTD; and Group 3 (n = 12), was not toilet trained preoperatively. Patients were reassessed regarding de novo LUTD or the persistence of LUTD at least 7 years after the ureteroneocystostomy...
January 11, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29318638/voltage-gated-sodium-channels-nav-igating-the-field-to-determine-their-contribution-to-visceral-nociception
#6
Andelain Erickson, Annemie Deiteren, Andrea M Harrington, Sonia Garcia-Caraballo, Joel Castro, Ashlee Caldwell, Luke Grundy, Stuart M Brierley
Chronic visceral pain, altered motility and bladder dysfunction are common, yet poorly managed symptoms of functional and inflammatory disorders of the gastrointestinal and urinary tracts. Recently, numerous human channelopathies of the voltage-gated sodium (NaV ) channel family have been identified, which induce either painful neuropathies, an insensitivity to pain, or alterations in smooth muscle function. The identification of these disorders, in addition to the recent utilisation of genetically modified NaV mice and specific NaV channel modulators, has shed new light on how NaV channels contribute to the function of neuronal and non-neuronal tissues within the gastrointestinal tract and bladder...
January 9, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29317060/fibromyalgia-and-unexplained-widespread-pain-the-idiopathic-cerebrospinal-pressure-dysregulation-hypothesis
#7
M Hulens, W Dankaerts, I Stalmans, A Somers, G Vansant, R Rasschaert, F Bruyninckx
Fibromyalgia (FM) is a debilitating, widespread pain disorder that is assumed to originate from inappropriate pain processing in the central nervous system. Psychological and behavioral factors are both believed to underlie the pathogenesis and complicate the treatment. This hypothesis, however, has not yet been sufficiently supported by scientific evidence and accumulating evidence supports a peripheral neurological origin of the symptoms. We postulate that FM and several unexplained widespread pain syndromes are caused by chronic postural idiopathic cerebrospinal hypertension...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29314212/lumbar-to-sacral-root-rerouting-to-restore-bladder-function-in-a-feline-spinal-cord-injury-model-urodynamic-and-retrograde-nerve-tracing-results-from-a-pilot-study
#8
Ornella Lam Van Ba, Mary F Barbe, Romain Caremel, Shachar Aharony, Oleg Loutochin, Line Jacques, Matthew W Wood, Ekta Tiwari, Gerald F Tuite, Lysanne Campeau, Jacques Corcos, Michael R Ruggieri
AIMS: Lumbar to sacral rerouting surgery can potentially allow voiding via a skin-central nervous system-bladder reflex pathway. Here, we assessed if this surgery was effective in treating neurogenic bladder dysfunction/sphincter in felines. METHODS: Eight cats underwent spinal cord transection (SCT) at thoracic level 10/11. Unilateral L7 to S1 ventral root anastomosis was performed 1 month later in six cats. Two cats served as transection-only controls. Electrical and manual stimulation of L6-S1 dermatomes, and urodynamics were performed at 3, 5, 7, and 9/10 months post transection...
January 4, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29313088/urodynamic-observations-and-lower-urinary-tract-symptoms-associated-with-endometriosis-a-prospective-cross-sectional-observational-study-assessing-women-with-deep-infiltrating-disease
#9
José Anacleto Dutra de Resende Júnior, Claudio Peixoto Crispi, Leon Cardeman, Renata Teles Buere, Márlon de Freitas Fonseca
INTRODUCTION AND HYPOTHESIS: The objective was to assess the association between lower urinary tract disease (LUTD) and the presence of endometriosis at different anatomical sites. METHODS: Our prospective cross-sectional observational study evaluated 138 women with deep infiltrating endometriosis who had undergone preoperative evaluation of urodynamics and detailed assessment of lower urinary tract symptoms between August 2013 and May 2016. After laparoscopy, the anatomical sites of histologically confirmed endometriosis lesions were mapped...
January 8, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29306638/rectus-abdominis-detrusor-myoplasty-radm-for-acontractile-hypocontractile-bladder-in-spinal-cord-injury-patients-preliminary-report
#10
Pawan Agarwal, Shabbir Husain, Sudesh Wankhede, D Sharma
BACKGROUND: Urinary bladder dysfunction in the form of acontractile/hypocontractile bladder is very common after spinal cord injury and it may lead to recurrent urinary tract infection (UTI), stones formation, and deteriorating renal function. Conventionally, these patients evacuate their bladders by life-long clean intermittent catheterization (CIC) or an indwelling catheter (IC). For these patients, another option is to use innervated skeletal muscle wrap around the bladder to augment detrusor function and voluntary evacuation of bladder...
December 14, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29306236/reliability-and-validity-of-the-bladder-and-bowel-dysfunction-questionnaireamong-turkish-children
#11
Fatma Kaya Narter, Fatih Tarhan, Kamil Fehmi Narter, Kubilay Sabuncu, Rabia Alay Eser, Yasemin Akın, Pınar Ay
Background/aim: We developed a Turkish version of the Bladder and Bowel Dysfunction Questionnaire (BBDQ) and evaluated its psychometric properties among Turkish pediatric patients.Materials and methods: The BBDQ was translated into Turkish and then it was back-translated into English. A total of 193 patients were asked to complete the Turkish version of the BBDQ as well as the Dysfunctional Voiding and Incontinence Scoring System (DVISS). In addition, 39 children completed the same questionnaires twice at 2-week intervals for test/retest evaluation...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29303389/a-modification-of-laparoscopic-type-c1-hysterectomy-to-reduce-postoperative-bladder-dysfunction-a-retrospective-study
#12
Wei Jiang, Meirong Liang, Douxing Han, Hui Liu, Ling Li, Meiling Zhong, Lin Luo, Siyuan Zeng
OBJECTIVE: To investigate the feasibility of a modified type C1 hysterectomy, using the deep uterine vein (DUV) and its branches as an anatomical landmark, to reduce postoperative bladder dysfunction in cervical cancer patients. METHODS: One hundred fifty-two stage IA2-IIB cervical cancer patients were enrolled to undergo a laparoscopic hysterectomy. According to the operation methods, 93 or 59 of the patients were assigned to a type C1 hysterectomy (group 1), using the DUV and its branches as an anatomical landmark, and a type C2 hysterectomy (group 2), respectively...
January 5, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29303111/chronic-implantation-of-cuff-electrodes-on-the-pelvic-nerve-in-rats-is-well-tolerated-and-does-not-compromise-afferent-or-efferent-fibre-functionality
#13
Jonathan J Crook, Charly Brouillard, Pedro Irazoqui, Thelma Lovick
Objective Neuromodulation of autonomic nerve activity to regulate physiological processes is an emerging field. Vagal stimulation has received most attention whereas the potential of modulate visceral function by targeting autonomic nerves within the abdominal cavity remains under-exploited. Surgery to locate intra-abdominal targets is inherently more stressful than for peripheral nerves. Electrode leads risk becoming entrapped by intestines and loss of functionality in the nerve-target organ connection could result from electrode migration or twisting...
January 5, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29302716/role-of-sacral-neuromodulation-in-modern-urogynaecology-practice-a-review-of-recent-literature
#14
REVIEW
Samina Tahseen
Sacral neuromodulation (SNM) offers promise in the therapy of many pelvic floor disorders. This innovative treatment has slowly gained popularity. A review of recent literature is presented in relation to its efficacy and complications in various pelvic floor conditions: overactive bladder and urge urinary incontinence, chronic urinary retention, painful bladder syndrome, pelvic pain and double incontinence. It is a minimally invasive, completely reversible safe procedure with good long-term outcomes. However, the treatment is costly, the revision rate is high and patients require life-long follow-up...
January 4, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29300259/sleep-quality-and-daytime-sleepiness-among-women-with-urgency-predominant-urinary-incontinence
#15
William D Winkelman, Ann Warsi, Alison J Huang, Michael Schembri, Rebecca G Rogers, Holly E Richter, Deborah L Myers, Stephen R Kraus, Karen C Johnson, Rachel Hess, Thomas Gregory, Catherine S Bradley, Lily A Arya, Jeanette S Brown, Katie L Stone, Leslee L Subak
OBJECTIVE: The objective of this study was to examine the strength and direction of the association between urinary symptoms and both poor quality sleep and daytime sleepiness among women with urgency urinary incontinence. METHODS: A planned secondary analysis of baseline characteristics of participants in a multicenter, double-blinded, 12-week randomized controlled trial of pharmacologic therapy for urgency-predominant urinary incontinence in ambulatory women self-diagnosed by the 3 Incontinence Questions was performed...
January 3, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29298467/impact-of-preoperative-patient-characteristics-and-flow-rate-on-failure-early-complications-and-voiding-dysfunction-after-a-transobturator-tape-procedure-a-multicentre-study
#16
Andrea Cocci, Giovanni E Cacciamani, Giorgio Ivan Russo, Maria Angela Cerruto, Martina Milanesi, Luis G Medina, Sebastiano Cimino, Walter Artibani, Giuseppe Morgia, Marco Carini, Vincenzo Li Marzi
PURPOSE: To evaluate the impact of preoperative patient characteristics and flow rate on failure, early postoperative complications, and voiding in patients who underwent transvaginal tension-free vaginal tape-obturator (TVT-O) treatment for uncomplicated stress urinary incontinence (SUI). METHODS: We retrospectively reviewed patients who underwent TVT-O for SUI at 3 Italian centres. The exclusion criteria were predominant voiding and storage symptoms suggestive of detrusor overactivity, the presence of grade >1 urogenital prolapse, previous pelvic radiotherapy or other clinical contraindications for surgical procedures, neurogenic bladder dysfunction, and collagen diseases...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29297596/neuropathology-of-autonomic-dysfunction-in-synucleinopathies
#17
REVIEW
Elizabeth A Coon, Jeremy K Cutsforth-Gregory, Eduardo E Benarroch
The synucleinopathies-Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure-result from distinct patterns of abnormal α-synuclein aggregation throughout the nervous system. Autonomic dysfunction in these disorders results from variable involvement of the central and peripheral autonomic networks. The major pathologic hallmark of Parkinson's disease and dementia with Lewy bodies is Lewy bodies and Lewy neurites; of multiple system atrophy, oligodendroglial cytoplasmic inclusions; and of pure autonomic failure, peripheral neuronal cytoplasmic inclusions...
January 3, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29291416/onset-of-action-of-sacral-neuromodulation-in-lower-urinary-tract-dysfunction-what-is-the-optimal-duration-of-test-stimulation
#18
R Jairam, J Drossaerts, T Marcelissen, G van Koeveringe, Ph Van Kerrebroeck
PURPOSE: Since the development of sacral neuromodulation (SNM) a large number of patients with lower urinary tract symptoms (LUTS) have been treated with SNM. A test stimulation is performed prior to implantation. In centres worldwide the duration of this test stimulation varies considerably since it is not certain when the onset of the therapy effect can be expected. The objective of this prospective study is to evaluate the average onset time of SNM in patients with LUTS. METHODS: All patients who were eligible for treatment with SNM were asked to participate...
December 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29287975/bladder-and-ureteral-dysfunction-leading-to-hydronephrosis-hydroureteronephrosis-in-adults
#19
REVIEW
Joao P Zambon, David S Koslov, Bianca Mihai, Gopal H Badlani
Chronic non-stone related hydronephrosis from supravesical or bladder dysfunction in adults is often detected incidentally. This study aims to review the literature regarding supravesical obstruction or bladder dysfunction leading to bilateral hydronephrosis in adults and develop an algorithm to identify patients at risk for renal failure. Cross-sectional studies, retrospective/prospective cohorts, clinical trials, and systematic reviews from 1980 to 2017 were included. From 8115 articles screened, 39 met the inclusion criteria...
December 26, 2017: Urology
https://www.readbyqxmd.com/read/29285288/synthetic-nickel-containing-superoxide-dismutase-attenuates-para-phenylenediamine-induced-bladder-dysfunction-in-rats
#20
Bing-Juin Chiang, Tien-Wen Chen, Shiu-Dong Chung, Way-Zen Lee, Chiang-Ting Chien
Para (p)-phenylenediamine and its toxic metabolites induce excess reactive oxygen species formation that results in bladder voiding dysfunction. We determined the effects of synthetic Ni-containing superoxide dismutase mimics and the role of oxidative stress in p-phenylenediamine-induced urinary bladder dysfunction. P-phenylenediamine (60 μg/kg/day) was intraperitoneally administered for 4 weeks to induce bladder injury in female Wistar rats. Synthetic Ni-containing superoxide dismutase mimics, WCT003 (1.5 mg/kg) and WCT006 (1...
December 1, 2017: Oncotarget
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