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https://www.readbyqxmd.com/read/28545452/a-simple-fast-and-inexpensive-method-for-mutation-scanning-of-cftr-gene
#1
Juan Emilio Figueredo Lago, Anny Armas Cayarga, Yaimé Josefina González González, Teresa Collazo Mesa
BACKGROUND: Mutation scanning methods in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene may not distinguish between a Cystic Fibrosis (CF) causing mutation and a benign variant. We have developed a simple and fast method for scanning 14 selected CF-causing mutations which have high frequency in Latin America. METHODS: In a group of 35 samples coming from CF patients previously characterized and using two allele-specific real-time multiplex PCRs targeting wild-type and mutant alleles respectively, we detect the presence of mutations by analyzing the Ct variation...
May 25, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28541459/is-the-linkage-of-census-and-health-data-justified-views-from-a-public-panel-of-the-scottish-health-and-ethnicity-linkage-study
#2
Anne Douglas, Hester J T Ward, Raj Bhopal, Theresa Kirkpatrick, Arma Sayed-Rafiq, Laurence Gruer
Background: Using routine health data for research aimed at improving health requires the public's awareness and trust. The Scottish Health and Ethnicity Linkage study explores variations in health between ethnic groups. We aimed to establish a public panel to obtain their views on its methods, findings and dissemination, including use of routine health data without individual opt-in consent. Methods: Adult applicants were sought via a range of sources, aiming for a balance of age, gender and ethnicity...
May 25, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28537914/epigenomic-study-identifies-a-novel-mesenchyme-homeobox2-gli1-transcription-axis-involved-in-cancer-drug-resistance-overall-survival-and-therapy-prognosis-in-lung-cancer-patients
#3
Leonel Armas-López, Patricia Piña-Sánchez, Oscar Arrieta, Enrique Guzman de Alba, Blanca Ortiz-Quintero, Patricio Santillán-Doherty, David C Christiani, Joaquín Zúñiga, Federico Ávila-Moreno
Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic responses in lung cancer patients; however, the mechanisms involved in these responses have yet to be elucidated. Here, an epigenomic strategy was implemented to identify novel MEOX2 gene promoter transcription targets and propose a new molecular mechanism underlying lung cancer drug resistance and poor clinical prognosis...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28532410/malaria-mortality-characterization-and-the-relationship-between-malaria-mortality-and-climate-in-chimoio-mozambique
#4
João Luís Ferrão, Jorge M Mendes, Marco Painho, Sara Zacarias
BACKGROUND: The United Nation's sustainable development goal for 2030 is to eradicate the global malaria epidemic, primarily as the disease continues to be one of the major concerns for public health in sub-Saharan Africa. In 2015, the region accounted for 90% of malaria deaths. Mozambique recorded a malaria mortality rate of 42.75 (per 100,000). In Chimoio, Mozambique's fifth largest city, malaria is the fourth leading cause of death (9.4%). Few data on malaria mortality exists in Mozambique, particularly in relation to Chimoio...
May 22, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28506446/serum-24-25-dihydroxyvitamin-d3-response-to-native-vitamin-d2%C3%A2-and%C3%A2-d3-supplementation-in-patients-with-chronic-kidney-disease%C3%A2-on%C3%A2-hemodialysis
#5
Laura A Graeff-Armas, Martin Kaufmann, Elizabeth Lyden, Glenville Jones
BACKGROUND & AIMS: While vitamin D deficiency is common in patients with end stage renal disease on dialysis and treatment with Vitamin D2 and Vitamin D3 is becoming increasingly common in these patients, little is known about 24,25(OH)2D3 metabolite production. Some authors report that the CYP24A1 enzyme is upregulated in CKD, but reports of low serum levels of 24,25(OH)2D3 in these patients bring this into question. Lack of substrate or increased clearance of the metabolite have been proposed as possible causes...
April 30, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28473945/does-testing-more-frequently-shorten-the-time-to-detect-disease-progression
#6
Johannes Ledolter, Randy H Kardon
PURPOSE: With the rise of smartphone devices to monitor health status remotely, it is tempting to conclude that sampling more often will provide a more sensitive means of detecting changes in health status earlier over time, when interventions may improve outcomes. METHODS: The answer to this question is derived in the context of a model where observations are generated from a linear-trend model with independent as well as autocorrelated autoregressive-moving average, or ARMA(1,1), errors...
May 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28463661/group-b-streptococcal-bacteriuria-during-pregnancy-as-a-risk-factor-for-maternal-intrapartum-colonization-a-prospective-cohort-study
#7
Mar Olga Pérez-Moreno, Ester Picó-Plana, Jesús Grande-Armas, Mª José Centelles-Serrano, Mercé Arasa-Subero, Núria Colomé- Ochoa, Members Of The Study Group Gessagte Led By Mo Pérez-Moreno
PURPOSE: Current evidence is inconclusive regarding the intrapartum administration of chemoprophylaxis, merely based on the presence of group B streptococcal (GBS) bacteriuria of any colony count, in the prevention of early-onset neonatal GBS infection. The aim of this study was to assess whether GBS bacteriuria is a risk factor for intrapartum colonization (IPC) regardless of urinary concentration or the results of late third-trimester rectovaginal screening cultures (RVSCs). METHODOLOGY: Six hundred and eight pregnant women, with urine specimens cultured between May 2011 and May 2013, were enrolled in this prospective cohort study...
April 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28459816/isotopic-reconstruction-of-the-weaning-process-in-the-archaeological-population-of-can%C3%A3-mar-abajo-cuba-a-bayesian-probability-mixing-model-approach
#8
Yadira Chinique de Armas, Mirjana Roksandic, Dejana Nikitović, Roberto Rodríguez Suárez, David Smith, Nadine Kanik, Dailys García Jordá, William M Buhay
The general lack of well-preserved juvenile skeletal remains from Caribbean archaeological sites has, in the past, prevented evaluations of juvenile dietary changes. Canímar Abajo (Cuba), with a large number of well-preserved juvenile and adult skeletal remains, provided a unique opportunity to fully assess juvenile paleodiets from an ancient Caribbean population. Ages for the start and the end of weaning and possible food sources used for weaning were inferred by combining the results of two Bayesian probability models that help to reduce some of the uncertainties inherent to bone collagen isotope based paleodiet reconstructions...
2017: PloS One
https://www.readbyqxmd.com/read/28457469/severe-bleeding-caused-by-giant-gastrointestinal-stromal-tumor-of-the-jejunum
#9
José Antonio Casimiro Pérez, María Asunción Acosta Mérida, María Del Mar Callejón Cara, Manuel Artiles Armas
No abstract text is available yet for this article.
April 27, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28448963/paradoxical-aging-in-hiv-immune-senescence-of-b-cells-is-most-prominent-in-young-age
#10
Stefano Rinaldi, Suresh Pallikkuth, Varghese K George, Lesley R de Armas, Rajendra Pahwa, Celeste M Sanchez, Maria Fernanda Pallin, Li Pan, Nicola Cotugno, Gordon Dickinson, Allan Rodriguez, Margaret Fischl, Maria Alcaide, Louis Gonzalez, Paolo Palma, Savita Pahwa
Combination antiretroviral therapies (cART)can lead to normal life expectancy in HIV-infected persons, and people aged >50 yrs represent the fastest growing HIV group. Although HIV and aging are independently associated with impaired humoral immunity, immune status in people aging with HIV is relatively unexplored. In this study influenza vaccination was used to probe age associated perturbations in the B cell compartment of HIV-negative "healthy controls" (HC) and virologically controlled HIV-infected participants on cART (HIV) (n=124), grouped by age as young (<40 yrs), middle-aged (40-59yrs) or old (>60 yrs)...
April 2017: Aging
https://www.readbyqxmd.com/read/28446899/clonal-spread-of-16s-rrna-methyltransferase-producing-klebsiella-pneumoniae-st37-with-high-prevalence-of-esbls-from-companion-animals-in-china
#11
Jing Xia, Liang-Xing Fang, Ke Cheng, Guo-Hao Xu, Xi-Ran Wang, Xiao-Ping Liao, Ya-Hong Liu, Jian Sun
We screened 30 Klebsiella pneumoniae isolates from dogs and cats at a single animal hospital in Guangdong Province, China. Among them, 12 K. pneumoniae strains possessed high-level resistance to amikacin and gentamicin and these were screened for 16S rRNA methyltransferase (16S-RMTase) genes. And then the genes positive isolates were detected for ESBLs (extended spectrum β-lactamases) and analyzed by pulsed-field gel electrophoresis, multilocus sequence typing, PCR-based replicon typing and plasmid analysis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28418786/evaluation-in-mice-of-the-immunogenicity-of-a-tetravalent-subunit-vaccine-candidate-against-dengue-virus-using-mucosal-and-parenteral-immunization-routes
#12
Laura Lazo Vázquez, Lázaro Gil González, Ernesto Marcos López, Yusleidi Pérez Fuentes, Lázaro Cervetto de Armas, Enma Brown Richards, Iris Valdés Prado, Edith Suzarte Portal, Karem Cobas Acosta, Melyssa Yaugel Novoa, Yaremis Romero Fernández, Gerardo Guillén Nieto, Lisset Hermida Cruz
Our group has developed a subunit vaccine candidate against Dengue virus (DENV) based on two different viral regions, the domain III of the envelope protein and the capsid protein. The chimeric proteins for each serotype (DIIIC1-4), aggregated with the oligodeoxynucleotide 39 M, form the tetravalent formulation named Tetra DIIIC. Tetra DIIIC induces a protective immune response in mice when it is inoculated by intraperitoneal route. However, if children are the main targets for a DENV vaccine, then a needle-free route of administration should be attractive and advantageous...
April 18, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28413506/active-efflux-pump-adeb-is-involved-in-multidrug-resistance-of-acinetobacter-baumannii-induced-by-antibacterial-agents
#13
Tingting Zhang, Min Wang, Yixin Xie, Xianping Li, Zhihui Dong, Yanhua Liu, Ling Wang, Min Yang, Huan Song, Hong Cao, Wei Cao
The aim of the present study was to investigate the resistance of Acinetobacter baumannii, which was induced by cefepime (FEP), cefoperazone-sulbactam (SCF), tazobactam (TZP), levofloxacin (LEV), amikacin (AK), imipenem (IPM), and ciprofloxacin (CIP), in vitro. Multi-step drug resistance selection of 16 A. baumannii strains was performed using seven antibacterial agents (FEP, TZP, CIP, AK, IPM, SCF, and LEV). The minimum inhibitory concentration (MIC) was determined using the agar dilution method. Random amplified polymorphic DNA polymerase chain reaction was performed to analyze the genotypes and the carrying rates of aac(3)-I, aac(6')-I, ant(3)-I, aph(3)-Via, OXA-23, OXA-24, AmpC, TEM-1, metallo-β-lactamase gene (IMP), armA, rmtA, rmtB, parC, gyrA and adeB...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28407345/dosimetric-impacts-of-endorectal-balloon-in-cyberknife-stereotactic-body-radiation-therapy-sbrt-for-early-stage-prostate-cancer
#14
Hong F Xiang, Hsiao-Ming Lu, Jason A Efstathiou, Anthony L Zietman, Ricardo De Armas, Kathryn Harris, B Nicolas Bloch, Muhammad Mustafa Qureshi, Sean Keohan, Ariel E Hirsch
PURPOSE: In SBRT for prostate cancer, higher fractional dose to the rectum is a major toxicity concern due to using smaller PTV margin and hypofractionation. We investigate the dosimetric impact on rectum using endorectal balloon (ERB) in prostate SBRT. MATERIALS AND METHODS: Twenty prostate cancer patients were included in a retrospective study, ten with ERB and 10 without ERB. Optimized SBRT plans were generated on CyberKnife MultiPlan for 5 × 7.25 Gy to PTV under RTOG-0938 protocol for early-stage prostate cancer...
April 13, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28405307/the-shift-from-plant-plant-facilitation-to-competition-under-severe-water-deficit-is-spatially-explicit
#15
Michael J O'Brien, Francisco I Pugnaire, Cristina Armas, Susana Rodríguez-Echeverría, Christian Schöb
The stress-gradient hypothesis predicts a higher frequency of facilitative interactions as resource limitation increases. Under severe resource limitation, it has been suggested that facilitation may revert to competition, and identifying the presence as well as determining the magnitude of this shift is important for predicting the effect of climate change on biodiversity and plant community dynamics. In this study, we perform a meta-analysis to compare temporal differences of species diversity and productivity under a nurse plant (Retama sphaerocarpa) with varying annual rainfall quantity to test the effect of water limitation on facilitation...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28395597/genome-sequencing-and-comparative-analysis-of-an-ndm-1-producing-klebsiella-pneumoniae-st15-isolated-from-a-refugee-patient
#16
Tamara Salloum, Harout Arabaghian, Sahar Alousi, Edmond Abboud, Sima Tokajian
The escalating problem of antibiotic resistance, specifically cabarpenemase and extended-spectrum β-lacatamase (ESBL) producing K. pneumoniae strains, is directly correlated with increased patient morbidity and mortality and prolonged hospitalization and costs. In this study, a comprehensive genomic analysis encompassing the resistomics, virulence repertoire and mobile genetic elements of an NDM-1 positive ESBL-producing K. pneumoniae EA-MEH ST15 isolated from a urine sample collected from a Syrian refugee was conducted...
April 11, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28386177/non-invasive-diagnosis-methods-of-coronary-disease-based-on-wavelet-denoising-and-sound-analyzing
#17
Tianhua Chen, Shuo Zhao, Siqi Shao, Siqun Zheng
The heart sound is the characteristic signal of cardiovascular health status. The objective of this project is to explore the correlation between Wavelet Transform and noise performance of heart sound and the adaptability of classifying heart sound using bispectrum estimation. Since the wavelet has multi-scale and multi-resolution characteristics, in this paper, the heart sound signal with different frequency ranges is decomposed through wavelet and displayed on different scales of the resolving wavelet result...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28382474/selection-and-characterization-of-coal-mine-autochthonous-rhizobia-for-the-inoculation-of-herbaceous-legumes
#18
Anabel González Hernández, Ginaini Doin de Moura, Renato Leal Binati, Francisco Xavier Inês Nascimento, Diana Morales Londoño, Ana Carolina Peixoto Mamede, Emanuela Pille da Silva, Rafael Dutra de Armas, Admir José Giachini, Márcio José Rossi, Cláudio Roberto Fonsêca Sousa Soares
Coal open pit mining in the South of Santa Catarina state (Brazil) was inappropriately developed, affecting approximately 6.700 ha. Re-vegetation is an alternative for the recovery of these areas. Furthermore, the use of herbaceous legumes inoculated with nitrogen fixing bacteria is motivated due to the difficulty implementing a vegetation cover in these areas, mainly due to low nutrient availability. Therefore, the aim of this work was to evaluate, among 16 autochthonous rhizobia isolated from the coal mining areas, those with the greatest potential to increase growth of the herbaceous legumes Vicia sativa and Calopogonium mucunoides...
April 5, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28372502/chemistry-and-redox-biology-of-mycothiol
#19
Aníbal Marcelo Reyes, Brandán Pedre Pérez, María Inés De Armas, Maria-Armineh Tossounian, Rafael Radi, Joris Messens, Madia Trujillo
SIGNIFICANCE: Mycothiol (MSH, AcCys-GlcN-Ins) is the main low molecular weight thiol of most Actinomycetes, including the human pathogen Mycobacterium tuberculosis that affects millions of people worldwide. Strains with decreased MSH content show increased susceptibilities to hydroperoxides and electrophilic compounds. In M. tuberculosis, MSH modulates the response to several anti-tuberculosis drugs. Enzymatic routes involving MSH could provide clues for specific drug design. Recent Advances...
April 3, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28329553/primary-cutaneous-marginal-zone-lymphoma
#20
Joshua Farhadian, Vtaly Terushkin, Shane A Meehan, Jo-Ann Latkowski
Primary cutaneous B cell lymphomas (PCBCL) are thesecond most common type of primary cutaneouslymphoma. The three main types of PCBCL areprimary cutaneous marginal-zone lymphoma(PCMZL), primary cutaneous follicle-centerlymphoma, and primary cutaneous diffuse largeB-cell lymphoma, leg type. PCMZL has an indolentcourse with a five-year survival rate approaching99%. Lesions most often present on the trunk or armas erythematous-to-violaceous papules, plaques, ornodules. Approximately one-half of patients havesolitary skin lesions...
December 15, 2016: Dermatology Online Journal
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