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Biswapriya B Misra, Zepeng Yin, Sisi Geng, Evaldo de Armas, Sixue Chen
Global CO2 level presently recorded at 400 ppm is expected to reach 550 ppm in 2050, an increment likely to impact plant growth and productivity. Using targeted LC-MS and GC-MS platforms we quantified 229 and 29 metabolites, respectively in a time-course study to reveal short-term responses to different concentrations (1, 3, and 10 mM) of bicarbonate (HCO3(-)) under light and dark conditions. Results indicate that HCO3(-) treatment responsive metabolomic changes depend on the HCO3(-) concentration, time of treatment, and light/dark...
October 20, 2016: Scientific Reports
Suzanne Gonzalez, Jayanta Gupta, Erika Villa, Indika Mallawaarachchi, Marco Rodriguez, Mercedes Ramirez, Juan Zavala, Regina Armas, Albana Dassori, Javier Contreras, Deborah Flores, Alvaro Jerez, Alfonso Ontiveros, Humberto Nicolini, Michael Escamilla
OBJECTIVES: Recent genome-wide association studies (GWASs) have identified numerous putative genetic polymorphisms associated with bipolar disorder (BD) and/or schizophrenia (SC). We hypothesized that a portion of these polymorphisms would also be associated with BD in the Latino American population. To identify such regions, we tested previously identified genetic variants associated with BD and/or SC and ancestral haploblocks containing these single nucleotide polymorphisms (SNPs) in a sample of Latino subjects with BD...
September 2016: Bipolar Disorders
Aníbal M Reyes, Diego S Vazquez, Ari Zeida, Martín Hugo, M Dolores Piñeyro, María Inés De Armas, Darío Estrin, Rafael Radi, Javier Santos, Madia Trujillo
Mycobacterium tuberculosis (M. tuberculosis) is the intracellular bacterium responsible for tuberculosis disease (TD). Inside the phagosomes of activated macrophages, M. tuberculosis is exposed to cytotoxic hydroperoxides such as hydrogen peroxide, fatty acid hydroperoxides and peroxynitrite. Thus, the characterization of the bacterial antioxidant systems could facilitate novel drug developments. In this work, we characterized the product of the gene Rv1608c from M. tuberculosis, which according to sequence homology had been annotated as a putative peroxiredoxin of the peroxiredoxin Q subfamily (PrxQ B from M...
October 14, 2016: Free Radical Biology & Medicine
Xiang Li, Ling Peng, Yuan Hu, Jing Shao, Tianhe Chi
With the rapid development of urbanization and industrialization, many developing countries are suffering from heavy air pollution. Governments and citizens have expressed increasing concern regarding air pollution because it affects human health and sustainable development worldwide. Current air quality prediction methods mainly use shallow models; however, these methods produce unsatisfactory results, which inspired us to investigate methods of predicting air quality based on deep architecture models. In this paper, a novel spatiotemporal deep learning (STDL)-based air quality prediction method that inherently considers spatial and temporal correlations is proposed...
October 13, 2016: Environmental Science and Pollution Research International
Xiao Li, Julio C Armas-Perez, Jose A Martinez-Gonzalez, Xiaoying Liu, Helou Xie, Camille Bishop, Juan P Hernandez-Ortiz, Rui Zhang, Juan J de Pablo, Paul F Nealey
The morphology and through-film optical properties of nematic liquid crystals (LCs) confined between two surfaces may be engineered to create switches that respond to external electric fields, thereby enabling applications in optoelectronics that require fast responses and low power. Interfacial properties between the confining surfaces and the LC play a central role in device design and performance. Here we investigate the morphology of LCs confined in hybrid cells with a top surface that exhibits uniform homeotropic anchoring and a bottom surface that is chemically patterned with sub-micron and micron- wide planar anchoring stripes in a background of homeotropic anchoring...
September 27, 2016: Soft Matter
Ye Zhou, Ashley Guo, Rui Zhang, Julio C Armas-Perez, José A Martínez-González, Mohammad Rahimi, Monirosadat Sadati, Juan J de Pablo
There is considerable interest in understanding and controlling topological defects in nematic liquid crystals (LCs). Confinement, in the form of droplets, has been particularly effective in that regard. Here, we employ a Landau-de Gennes formalism to explore the geometrical frustration of nematic order in shell geometries, and focus on chiral materials. By varying the chirality and thickness in uniform shells, we construct a phase diagram that includes tetravalent structures, bipolar structures (BS), bent structures and radial spherical structures (RSS)...
September 30, 2016: Soft Matter
Pablo Armas, Aldana David, Nora Calcaterra
G-quadruplexes are non-canonical DNA secondary structures involved in several genomic and molecular processes. Here we summarize the main G-quadruplex features and evidences proving the in vivo role on the transcriptional regulation of genes required for zebrafish embryonic development. We also discuss alternative strategies for specifically interfering G-quadruplex in vivo.
October 3, 2016: Transcription
Kelly Justin da Silva, Rafael Dutra de Armas, Cláudio Roberto F S Soares, Juliana Bernardi Ogliari
The diversity of endophytic microorganisms may change due to the genotype of the host plant and its phenological stage. In this study we evaluated the effect of phenological stage, transgenes and genetic composition of maize on endophytic bacterial and fungal communities. The maize populations were composed of a local variety named Rosado (RS) and three isogenic hybrids. One isogenic hybrid was not genetically modified (NGM). Another hybrid (Hx) contained the transgenes cry1F and pat (T1507 event), which provide resistance to insects of the order Lepidoptera and tolerance to the glufosinate-ammonium herbicide, respectively...
November 2016: World Journal of Microbiology & Biotechnology
Amel Ayad, Mourad Drissi, Claire de Curraize, Chloé Dupont, Alain Hartmann, Sébastien Solanas, Eliane Siebor, Lucie Amoureux, Catherine Neuwirth
The aim of this study, was to characterize the extended-spectrum-β-lactamases (ESBLs) producing clinical strains of Escherichia coli isolated between January 2009 and June 2012 from Algerian hospitals and to determine the prevalence of 16S rRNA methylase among them. Sixty-seven ESBL-producers were detected among the 239 isolates included: 52 CTX-M-15-producers, 5 CTX-M-3-producers, 5 CTX-M-1-producers, 2 CTX-M-14-producers, 2 SHV-12-producers and one TEM-167-producer. Among the ESBL-producing strains twelve harbored 16S rRNA methylase genes: 8 rmtB and 4 armA...
2016: Frontiers in Microbiology
Ana Rosa Vieira Melo, Amanda Ramos, Nadiya Kazachkova, Mafalda Raposo, Bruno Filipe Bettencourt, Ana Rita Rendeiro, Teresa Kay, João Vasconcelos, Jácome Bruges-Armas, Manuela Lima
INTRODUCTION AND OBJECTIVE: Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) disorder for which the routine molecular testing is based on PCR and automated capillary electrophoresis. When only a normal allele is detected by standard PCR, the hypothesis of a failed amplification of the expanded allele must be raised. In such cases, complementary techniques such as Southern Blot or triplet repeat primed PCR (TP-PCR) have to be applied. For SCA3, TP-PCR is implemented in some diagnostic laboratories, but a tested protocol has yet to be published...
September 20, 2016: Molecular Diagnosis & Therapy
Catiane Pelissari, Cristina Ávila, Camila Maria Trein, Joan García, Rafael Dultra de Armas, Pablo Heleno Sezerino
The aim of this study was to characterize the nitrogen transforming bacterial communities within a partially saturated vertical subsurface flow constructed wetland (VF) treating urban wastewater in southern Brazil. The VF had a surface area of 3144m(2), and was divided into four wetland cells, out of which two were operated while the other two rested, alternating cycles of 30days. The nitrifying and denitrifying bacterial communities were characterized in wetland cell 3 (764m(2) surface area) over a period of 12months by using the FISH technique...
September 15, 2016: Science of the Total Environment
Katarzyna Piekarska, Katarzyna Zacharczuk, Tomasz Wołkowicz, Magdalena Rzeczkowska, Elżbieta Bareja, Monika Olak, Rafał Gierczyński
BACKGROUND: Aminoglycosides are a group of antimicrobial agents still the most commonly used in the treatment of life-threatening bacterial infections in human and animals. The emergence and spread of 16S rRNA methylases, which confer high-level resistance to the majority of clinically relevant aminoglycosides, constitute a major public health concern. OBJECTIVES: Our goal was to evaluate the distribution of 16S rRNA methylases among different species of Enterobacteriaceae during a five month-long survey in a tertiary hospital in Warszawa, Poland...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Qiongge Li, Maria F Chan
Over half of cancer patients receive radiotherapy (RT) as partial or full cancer treatment. Daily quality assurance (QA) of RT in cancer treatment closely monitors the performance of the medical linear accelerator (Linac) and is critical for continuous improvement of patient safety and quality of care. Cumulative longitudinal QA measurements are valuable for understanding the behavior of the Linac and allow physicists to identify trends in the output and take preventive actions. In this study, artificial neural networks (ANNs) and autoregressive moving average (ARMA) time-series prediction modeling techniques were both applied to 5-year daily Linac QA data...
September 14, 2016: Annals of the New York Academy of Sciences
Gabriela López-Armas, Mario Eduardo Flores-Soto, Verónica Chaparro-Huerta, Luis Felipe Jave-Suarez, Sofía Soto-Rodríguez, Iryna Rusanova, Dario Acuña-Castroviejo, Oscar González-Perez, Rocío Elizabeth González-Castañeda
Purpose. The aim of this study was to assess the effect of melatonin in the proliferation of neural progenitors, melatonin concentration, and antiapoptotic proteins in the hippocampus of adult mice exposed to 96 h REM sleep deprivation (REMSD) prophylactic administration of melatonin for 14 days. Material and Methods. Five groups of Balb/C mice were used: (1) control, (2) REMSD, (3) melatonin (10 mg/kg) plus REMSD, (4) melatonin and intraperitoneal luzindole (once a day at 5 mg/kg) plus REMSD, and (5) luzindole plus REMSD...
2016: Oxidative Medicine and Cellular Longevity
Cristina Gutiérrez-Delgado, Daniel Armas-Texta, Nancy Reynoso-Noverón, Abelardo Meneses-García, Alejandro Mohar-Betancourt
OBJECTIVE: To estimate the indirect costs generated by adults with cancer in Mexico from 2002-2020. MATERIALS AND METHODS: Using information from national sources and the national cancer incidence from GLOBOCAN, we estimated income lost due to premature death (ILPD), short-term benefits (STBs), disability pensions (DPs), and opportunity costs for the carer (OCCs) generated by patients with cancer. Amounts were reported in Mexican pesos. RESULTS: We estimated 23 359 deaths and 216 679 new cases of cancer by 2020, which would be associated with a total indirect cost of 20...
April 2016: Salud Pública de México
Somdatta Chatterjee, Saswati Datta, Subhasree Roy, Lavanya Ramanan, Anindya Saha, Rajlakshmi Viswanathan, Tapas Som, Sulagna Basu
Carbapenem-resistant determinants and their surrounding genetic structure were studied in Acinetobacter spp. from neonatal sepsis cases collected over 7 years at a tertiary care hospital. Acinetobacter spp. (n = 68) were identified by ARDRA followed by susceptibility tests. Oxacillinases, metallo-β-lactamases (MBLs), extended-spectrum β-lactamases and AmpCs, were detected phenotypically and/or by PCR followed by DNA sequencing. Transconjugants possessing the bla NDM-1(New Delhi metallo-β-lactamase) underwent further analysis for plasmids, integrons and associated genes...
2016: Frontiers in Microbiology
Liusheng Fan, Ming Ke, Min Yuan, Ji Pu, Juan Li, Jinxing Lu, Jianguo Xu, Mei Zhang, Wei Xu
RATIONALE: Antibiotic resistance in pathogenic bacteria is becoming a global public health problem, such as aminoglycoside resistance encoded by the armA gene. Although many methods have been reported, rapid analysis of environmental samples is still challenging. METHOD: A rapid analytical method was developed in this study to determine bacterial aminoglycoside resistance using membrane electrospray ionization mass spectrometry (MESI-MS). Precursor/product-ion pairs of ArmA unique peptides were detected with minimal sample preparation...
August 2016: Rapid Communications in Mass Spectrometry: RCM
Diana M Cheng, Diana E Roopchand, Alexander Poulev, Peter Kuhn, Isabel Armas, William D Johnson, Andrew Oren, David Ribnicky, Ehud Zelzion, Debashish Bhattacharya, Ilya Raskin
SCOPE: The ability of high phenolic Rutgers Scarlet Lettuce (RSL) to attenuate metabolic syndrome and gut dysbiosis was studied in very high fat diet (VHFD)-fed mice. Phenolic absorption was assessed in vivo and in a gastrointestinal tract model. METHODS AND RESULTS: Mice were fed VHFD, VHFD supplemented with RSL (RSL-VHFD) or store-purchased green lettuce (GL-VHFD), or low-fat diet (LFD) for 13 weeks. Compared to VHFD or GL-VHFD-fed groups, RSL-VHFD group showed significantly improved oral glucose tolerance (p<0...
August 16, 2016: Molecular Nutrition & Food Research
Michelle Rich, Lukasz Mendecki, Samantha T Mensah, Enrique Blanco-Martinez, Stephanie Armas, Percy Calvo-Marzal, Aleksandar Radu, Karin Y Chumbimuni-Torres
Preparation of ion-selective electrodes (ISEs) often requires long and complicated conditioning protocols limiting their application as tools for in-field measurements. Herein, we eliminated the need for electrode conditioning by loading the membrane cocktail directly with primary ion solution. This proof of concept experiment was performed with iodide, silver, and sodium selective electrodes. The proposed methodology significantly shortened the preparation time of ISEs, yielding functional electrodes with submicromolar detection limits...
September 6, 2016: Analytical Chemistry
Bruno Filipe Bettencourt, João Paulo Pinheiro, Jácome Bruges Armas
One hundred and twenty-seven unrelated Azorean individuals were randomly selected to study the gene frequencies of Killer-cell immunoglobulin-like receptors (KIR) in the Azorean (Terceira) population. KIR genotyping was performed by polymerase chain reaction using commercial sequence-specific oligonucleotide probe kits. All loci were in HWE, showing no locus-level deviations. The genotype data is available in the Allele Frequencies Net Database under the population name ''Azores Terceira Island KIR''.
August 5, 2016: Human Immunology
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