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https://www.readbyqxmd.com/read/28757356/flibanserin-from-bench-to-bedside
#1
REVIEW
Erin M Dooley, Melanie K Miller, Anita H Clayton
INTRODUCTION: The process of approval for flibanserin (trade name Addyi) has been associated with controversy since before its approval on August 18, 2015. This argument centered on challenges to the validity of the diagnosis of hypoactive sexual desire disorder in women and the safety and efficacy of the drug. AIM: To explore the process of Food and Drug Administration (FDA) approval for flibanserin and delve further into the research, concerns, and various roadblocks to its approval...
July 27, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28733191/ethnomedicobotanical-study-of-indigenous-knowledge-on-medicinal-plants-used-for-the-treatment-of-reproductive-problems-in-nalbari-district-assam-india
#2
Simi Talukdar, Partha Pradip Adhikari, Ananta Borah
ETHNOPHARMACOLOGICAL RELEVANCE: Reproductive problems are evolving as most predominant health care problems in many countries, furthermore, WHO, 2012 exemplified maternal illnesses, birth asphyxia and post birth difficulties, are rising at an alarming rate.Not all abnormalities of the human reproductive system have the same origin; the effects on reproductive problems would likely be affected by both male and female. For easy accessibility and affordability medicinal plants play a key role in primary healthcare care services in India and their use is an integral part of the cultural heritage...
July 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28714924/cross-sectional-study-to-determine-the-prevalence-of-hepatitis-b-and-c-virus-infection-in-high-risk-groups-in-the-northeast-region-of-brazil
#3
Jakeline Ribeiro Barbosa, Cristianne Sousa Bezerra, Filipe Anibal Carvalho-Costa, Carolina Pimentel de Azevedo, Geane Lopes Flores, Jeová Keny Baima Colares, Danielle Malta Lima, Elisabeth Lampe, Lívia Melo Villar
Background: HBV (Hepatitis B Virus) and HCV (Hepatitis C Virus) infections are more prevalent in vulnerable populations than the general population. The objective of this study was to investigate the prevalence of HBV and HCV infection in HIV-positive patients (GI), chronic renal failure (CRF) patients (GII) and coagulation disorder individuals (GIII). Methods: A cross-sectional study was conducted from June 2014 to March 2015. Serum samples were tested for markers of hepatitis B and C by enzyme-linked immunosorbent assay (ELISA)...
July 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28657995/one-and-the-same-nocturnal-enuresis-and-overactive-bladder-in-the-female-veteran-population-evaluation-of-a-large-national-database
#4
Cara Ninivaggio, Heather Riese, Gena C Dunivan, Peter C Jeppson, Yuko M Komesu, Allison Murata, Glen Murata, Rebecca G Rogers, Sara B Cichowski
OBJECTIVES: The aims of this study were to describe relationships between women given a diagnosis of nocturnal enuresis (NE) and controls without any urinary complaints and to compare women with NE with those with overactive bladder (OAB). We hypothesized that NE has unique associations with demographics and medical and psychosocial diagnoses. METHODS: This is a secondary analysis of a database that included all female veterans who established care with a primary care provider from 1997 to 2015...
June 27, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28605242/sexual-behavior-in-patients-with-psychosis-admitted-to-a-hospital-unit
#5
María Del Mar Baños-Martín, Verónica V Márquez-Hernández, Lorena Gutiérrez-Puertas, Gabriel Aguilera-Manrique, Vanesa Gutiérrez-Puertas, Genoveva Granados-Gámez
The sexual dimension is part of a person's functionality. Patients with mental disorders have the same sexual needs as any other person, although they may not always be recognized. This is a retrospective observational study to describe the information on sexuality of patients with mental disorders, admitted to an acute short-stay inpatient unit between 2011 and 2015. We analyzed 293 clinical histories of patients, comprising diagnoses in the ICD-10 (International Classification of Diseases) between F20 and F29, inclusively...
June 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28495602/a-review-of-traditional-uses-phytochemistry-and-pharmacology-of-portulaca-oleracea-l
#6
REVIEW
Milad Iranshahy, Behjat Javadi, Mehrdad Iranshahi, Seyedeh Pardis Jahanbakhsh, Saman Mahyari, Faezeh Vahdati Hassani, Gholamreza Karimi
ETHNOPHARMACOLOGICAL RELEVANCE: Portulaca oleracea L. is a widespread medicinal plant that is used not only as an edible plant, but also as a traditional medicine for alleviating a wide spectrum of diseases. It is a well-known plant in the European Traditional Medicine. PA is mentioned by Dioscorides (40-90 CE), with the name of "andrachne". AIM OF THE REVIEW: In this study, we provide detailed information on botany, traditional uses, phytochemistry, pharmacological uses, pharmacokinetics and safety of P...
May 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28481898/zika-virus-like-particle-vlp-based-vaccine
#7
Hélène Boigard, Alexandra Alimova, George R Martin, Al Katz, Paul Gottlieb, Jose M Galarza
The newly emerged mosquito-borne Zika virus poses a major public challenge due to its ability to cause significant birth defects and neurological disorders. The impact of sexual transmission is unclear but raises further concerns about virus dissemination. No specific treatment or vaccine is currently available, thus the development of a safe and effective vaccine is paramount. Here we describe a novel strategy to assemble Zika virus-like particles (VLPs) by co-expressing the structural (CprME) and non-structural (NS2B/NS3) proteins, and demonstrate their effectiveness as vaccines...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28442935/new-developments-in-the-treatment-of-hypoactive-sexual-desire-disorder-a-focus-on-flibanserin
#8
REVIEW
Christopher J Jayne, Michael J Heard, Sarah Zubair, Dustie L Johnson
The objective of the authors is to highlight the historical complexities for the diagnosis and treatment of hypoactive sexual desire disorder (HSDD) with a focus on Flibanserin. A systematic review of the medical literature published in PubMed using the search terms HSDD and Flibanserin was conducted. Each author reviewed the results of the systematic review for articles to include in this study. HSDD is defined as a persistent or recurrent deficiency or absence of sexual fantasies and desire for sexual activity causing marked distress or interpersonal difficulty that is not better accounted for by another diagnosis...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28424504/prevalence-and-factors-associated-with-erectile-dysfunction-in-patients-with-chronic-kidney-disease-on-conservative-treatment
#9
M R Costa, V C Ponciano, T R Costa, A M de Oliveira, C P Gomes, E C de Oliveira
Population with chronic kidney disease (CKD) has had many problems, and some of these have arisen from sexual disorders. The present study intends to determine the prevalence and the associated factors with erectile dysfunction (ED) among patients with CKD on conservative treatment (CKDCT). This transversal study was conducted from May 2013 to December 2015. The tools used were: medical records and the International Index of Erectile Function. Data were analyzed by univariate and multivariate logistic regression analysis...
April 20, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28397671/-flibanserin-as-pharmacological-therapy-of-inhibited-sexual-desire-in-women
#10
Anne Sofie Eldon, Annamaria Giraldi
Flibanserin was approved by the Food and Drug Administration in the USA in August 2015 as the first drug for the treatment of American women with the dysfunction hypoactive sexual desire disorder (HSDD) and is a 5-HT1A agonist and 5-HT2A antagonist. The neurophysiological effects of flibanserin on these receptors are consistent with the clinical effects, i.e. significantly increasing sexual desire and frequency of satisfying sexual experiences. As such, shifting the balance between inhibitory and excitatory neurotransmitters of importance to sexual desire, flibanserin pharmacologically broaches a possible new approach to the treatment of HSDD...
February 13, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28389688/intimate-partner-violence-and-mental-ill-health-among-global-populations-of-indigenous-women-a-systematic-review
#11
REVIEW
Marta Chmielowska, Daniela C Fuhr
PURPOSE: Intimate partner violence (IPV) has been recognised as a major obstacle to the achievement of gender equality and human development. Its adverse physical and mental health consequences have been reported to affect women of all ages and backgrounds. Although Indigenous women seem to experience higher rates of partner abuse than non-Indigenous women, mental health consequences of IPV among this population are not yet clearly established in the literature. This study systematically reviewed the global literature on mental health outcomes and risk factors for mental ill health among Indigenous women who experienced IPV...
June 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28369422/ileal-pouch-anal-anastomosis-for-dysplasia-or-cancer-complicating-inflammatory-bowel-disease-is-total-mesorectal-excision-always-mandatory-an-analysis-of-36-consecutive-patients
#12
Chloé Coton, Léon Maggiori, Diane Mège, Clotilde Naudot, Justine Prost À la Denise, Yves Panis
Background and Aims: The extent of lymph node harvesting during surgery for colorectal neoplasm [dysplasia and/or cancer] complicating inflammatory bowel disease [IBD] is a matter of debate. This study aimed to assess the risk of invasive rectal cancer in patients undergoing ileal pouch-anal anastomosis [IPAA] for colonic neoplasm complicating IBD, and thus to clarify whether a systematic total mesorectal excision [TME] should be systematically performed, or not, in those patients. Methods: From 1998 to 2015, all patients who underwent IPAA for colorectal neoplasm complicating IBD were included...
August 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28289788/-failure-of-a%C3%A2-study-in-forensic-psychiatric-hospitals-clinical-trial-to-investigate-the-additive-effect-of-triptorelin-on-the-efficacy-of-psychotherapy
#13
Peer Briken, Jürgen L Müller, Wolfgang Berner, Rolf-Hasso Bödeker, Jochen Vollmann, Christian Kasperk, Matthias Koller
BACKGROUND: A testosterone-lowering medication is relatively commonly used as a form of treatment for sexual offenders with severe paraphilic disorders in German forensic psychiatric hospitals; however, a double-blind, controlled and randomized study, which investigates the efficacy of this medication, is still lacking. AIM: This article describes the process from the planning to the rejection of a clinical trial over the period from 2009 to 2015. METHODS AND RESULTS: Despite the careful planning with an interdisciplinary team and giving special consideration to the complex legal situation, the Federal Institute for Drugs and Medical Devices (BfArM) rejected the proposed trial in a brief formal letter with reference to the German Drug Law (§ 40 para...
March 13, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28222491/the-predictors-of-quality-of-life-in-women-with-polycystic-ovarian-syndrome
#14
Fatemeh Aliasghari, Mojgan Mirghafourvand, Sakineh Mohammad-Alizadeh Charandabi, Tahereh Behroozi Lak
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorder that may be effective in reducing the quality of life. This study aimed to determine the predictors of quality of life in women with PCOS. This cross-sectional study was conducted on 174 women with PCOS who attended in public and private fertility clinics in Urmia (West Azerbaijan, Iran), 2015. The data were collected through the questionnaires of sociodemographic and obstetrics characteristics, quality of life and Beck depression inventory-II...
February 21, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28220549/somatic-psychological-and-sexual-triggers-for-overactive-bladder-syndrome-in-women
#15
Ariel Zilberlicht, Nir Haya, Ido Feferkorn, Eyal Goldschmidt, Anis Kaldawy, Yoram Abramov
AIMS: Patients with overactive bladder (OAB) often describe somatic, psychological, and sexual triggers for their symptoms. The aim of this study was to characterize these triggers and assess their impact on patients' symptoms and quality of life (QoL). METHODS: Patients who visited our urogynecologic clinic between August 2015 and March 2016 and diagnosed with OAB syndrome were asked to fill a questionnaire comprising 34 statements regarding SOmatic, Psychological, and Sexual Triggers for OAB (SOPSETO)...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28208946/the-impact-of-intimate-male-partner-violence-on-women-s-sexual-function-a-study-in-iran
#16
Safieh Jamali, Shohreh Javadpour
INTRODUCTION: Sexuality is an integral part of a woman's life. A variety of factors can affect a woman's sexuality, among them physical disorders, social-religious beliefs, age, psychological factors, depression, mental tension, disbelief, an unfulfilling relationship with one's spouse and emotional and physical violence. AIM: The present study aimed to explore the rate of domestic violence against women and its impact on women's sexuality. MATERIALS AND METHODS: This cross-sectional study was conducted on 813 women referring to the gynaecology clinics of Jahrom, Iran, from April to October 2015...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203348/flibanserin-for-hypoactive-sexual-desire-disorder-place-in-therapy
#17
REVIEW
Faina Gelman, Jessica Atrio
The pathophysiology, diagnosis and treatment of female sexual interest in pre- and post-menopausal women present a complex arena for patients and physicians to navigate. Flibanserin was the first pharmacologic treatment, approved by the United States Food and Drug Administration in August 2015, for hypoactive sexual desire disorder (HSDD) in premenopausal women. Side effects, contraindications and lack of approval in postmenopausal women are all limitations, as are issues surrounding patient and physician knowledge and access...
January 2017: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/28185995/study-protocol-community-links-to-establish-alcohol-recovery-clear-for-women-leaving-jail
#18
Jennifer E Johnson, Yael Chatav Schonbrun, Bradley Anderson, Megan Kurth, Christine Timko, Michael Stein
PURPOSE: This article describes the protocol for a randomized effectiveness trial of a method to link alcohol use disordered women who are in pretrial jail detention with post-release 12-step mutual help groups. BACKGROUND: Jails serve 15 times more people per year than do prisons and have very short stays, posing few opportunities for treatment or treatment planning. Alcohol use is associated with poor post-jail psychosocial and health outcomes including sexually transmitted diseases and HIV, especially for women...
April 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28108189/the-longitudinal-impact-of-an-internet-safety-decision-aid-for-abused-women
#19
Nancy E Glass, Nancy A Perrin, Ginger C Hanson, Tina L Bloom, Jill T Messing, Amber S Clough, Jacquelyn C Campbell, Andrea C Gielen, James Case, Karen B Eden
INTRODUCTION: Women experiencing intimate partner violence (IPV) navigate complex, dangerous decisions. Tailored safety information and safety planning, typically provided by domestic violence service providers, can prevent repeat IPV exposure and associated adverse health outcomes; however, few abused women access these services. The Internet represents a potentially innovative way to connect abused women with tailored safety planning resources and information. The purpose of this study was to compare safety and mental health outcomes at baseline, 6 months, and 12 months among abused women randomized to: (1) a tailored, Internet-based safety decision aid; or (2) control website (typical safety information available online)...
January 17, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28065419/a-study-on-sexual-violence-inflicted-on-individuals-with-intellectual-developmental-disorder
#20
A N Vadysinghe, P B Dassanayaka, M Sivasubramanium, D P P Senasinghe, A N Samaranayake, W M M H P Wickramasinghe
BACKGROUND: Rates of violence and abuse perpetrated on people with intellectual and developmental disability (IDD) have been reported to be significantly higher than on individuals without disability. However, rates of sexual violence against people with IDD in some less industrialized countries, such as Sri Lanka, have not been previously reported. OBJECTIVES: To describe characteristics of victims and perpetrators as well as the types of abuse found during medicolegal examinations of patients with IDD...
December 21, 2016: Disability and Health Journal
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