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https://www.readbyqxmd.com/read/28905302/non-health-care-facility-medication-errors-associated-with-hormones-and-hormone-antagonists-in-the-united-states
#1
Pranav Magal, Henry A Spiller, Marcel J Casavant, Thitphalak Chounthirath, Nichole L Hodges, Gary A Smith
INTRODUCTION: Hormones and hormone antagonists are frequently associated with medication errors and may result in important adverse outcomes. The purpose of this study is to investigate non-health care facility (non-HCF) medication errors associated with hormones and hormone antagonists in the United States (US). METHODS: A retrospective analysis of National Poison Data System data was conducted to identify characteristics and trends of unintentional non-HCF therapeutic errors involving hormones and hormone antagonists among individuals of all ages from 2000 to 2012...
September 13, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28721472/a-model-for-transfer-of-p-glycoproteins-in-mcf-7-breast-cancer-cell-line-with-multiple-transfer-rules
#2
P Magal, A Noussair, J Pasquier, P Zongo, F Le Foll
In this paper, we consider a direct protein transfer process between cells in co-culture. Assuming that cells continually encounter each other, and from some hypotheses on cell-to-cell rules of transfer, we derive discrete and continuous Boltzmann-like integro-differential equations. The novelty of this model is to take into account multiple transfer rules. This new transfer model is used to fit the experimental data of cell-to-cell protein transfer in breast cancer.
July 18, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28686616/diagnostic-accuracy-of-tablet-based-software-for-the-detection-of-concussion
#3
Suosuo Yang, Benjamin Flores, Rotem Magal, Kyrsti Harris, Jonathan Gross, Amy Ewbank, Sasha Davenport, Pablo Ormachea, Waleed Nasser, Weidong Le, W Frank Peacock, Yael Katz, David M Eagleman
Despite the high prevalence of traumatic brain injuries (TBI), there are few rapid and straightforward tests to improve its assessment. To this end, we developed a tablet-based software battery ("BrainCheck") for concussion detection that is well suited to sports, emergency department, and clinical settings. This article is a study of the diagnostic accuracy of BrainCheck. We administered BrainCheck to 30 TBI patients and 30 pain-matched controls at a hospital Emergency Department (ED), and 538 healthy individuals at 10 control test sites...
2017: PloS One
https://www.readbyqxmd.com/read/28635035/effect-of-selective-cf3-substitution-on-the-physical-and-chemical-properties-of-gold-corroles
#4
Kolanu Sudhakar, Amir Mizrahi, Monica Kosa, Natalia Fridman, Boris Tumanskii, Magal Saphier, Zeev Gross
Gold corroles are not readily accessible and they display no interesting physical or chemical properties. A facile methodology has now been developed for obtaining selectively CF3 -substituted gold(III) corroles and the introduction of these groups has been found to have an immense effect on the structures of the complexes, their photophysical and redox properties, and on their ability to participate in catalytic processes.
June 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28557860/applying-the-acsm-preparticipation-screening-algorithm-to-u-s-adults-national-health-and-nutrition-examination-survey-2001-2004
#5
Geoffrey P Whitfield, Deborah Riebe, Meir Magal, Gary Liguori
PURPOSE: For most people, the benefits of physical activity far outweigh the risks. Research has suggested that exercise preparticipation questionnaires might refer an unwarranted number of adults for medical evaluation before exercise initiation, creating a potential barrier to adoption. The new American College of Sports Medicine (ACSM) prescreening algorithm relies on current exercise participation; history and symptoms of cardiovascular, metabolic, or renal disease; and desired exercise intensity to determine referral status...
October 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28317099/mutations-in-ergic1-cause-arthrogryposis-multiplex-congenita-neuropathic-type
#6
E Reinstein, V Drasinover, R Lotan, M Gal-Tanamy, I Bolocan Nachman, E Eyal, L Jaber, N Magal, M Shohat
Arthrogryposis multiplex congenita (AMC) is heterogeneous group of disorders characterized by non-progressive joint contractures from birth that involve more than 1 part of the body. There are various etiologies for AMC including genetic and environmental depends on the specific type, however, for most types, the cause is not fully understood. We previously reported large Israeli Arab kindred consisting of 16 patients affected with AMC neuropathic type, and mapped the locus to a 5.5 cM interval on chromosome 5qter...
March 19, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28263186/loss-of-ddrgk1-modulates-sox9-ubiquitination-in-spondyloepimetaphyseal-dysplasia
#7
Adetutu T Egunsola, Yangjin Bae, Ming-Ming Jiang, David S Liu, Yuqing Chen-Evenson, Terry Bertin, Shan Chen, James T Lu, Lisette Nevarez, Nurit Magal, Annick Raas-Rothschild, Eric C Swindell, Daniel H Cohn, Richard A Gibbs, Philippe M Campeau, Mordechai Shohat, Brendan H Lee
Shohat-type spondyloepimetaphyseal dysplasia (SEMD) is a skeletal dysplasia that affects cartilage development. Similar skeletal disorders, such as spondyloepiphyseal dysplasias, are linked to mutations in type II collagen (COL2A1), but the causative gene in SEMD is not known. Here, we have performed whole-exome sequencing to identify a recurrent homozygous c.408+1G>A donor splice site loss-of-function mutation in DDRGK domain containing 1 (DDRGK1) in 4 families affected by SEMD. In zebrafish, ddrgk1 deficiency disrupted craniofacial cartilage development and led to decreased levels of the chondrogenic master transcription factor sox9 and its downstream target, col2a1...
April 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28238703/competition-for-light-in-forest-population-dynamics-from-computer-simulator-to-mathematical-model
#8
Pierre Magal, Zhengyang Zhang
In this article we build a mathematical model for forest growth and we compare this model with a computer forest simulator named SORTIE. The main ingredient taken into account in both models is the competition for light between trees. The parameters of the mathematical model are estimated by using SORTIE model, when the parameter values of SORTIE model correspond to the ones previously evaluated for the Great Mountain Forest in USA. We see that the best fit of the parameters of the mathematical model is obtained when the competition for light influences only the growth rate of trees...
February 24, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28182414/the-planar-cyclooctatetraene-bridge-in-bis-metallic-macrocycles-isolating-or-conjugating
#9
Susovan Bhowmik, Monica Kosa, Amir Mizrahi, Natalia Fridman, Magal Saphier, Amnon Stanger, Zeev Gross
A minor modification of the reported procedure for the synthesis of a corrole dimer that is fused by the cyclooctatetraene (COT) unit, (H3tpfc)2COT, allowed for its isolation in 18% yield. Of the two redox isomers that this interesting macrocycle does form, the current focus is on the reduced form, in which each subunit resembles that of monomeric corroles with a trianionic N4 coordination core. The corresponding bis-gallium(III) complex was prepared as an entry into the potentially rich coordination chemistry of (H3tpfc)2COT...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/27869390/-factors-related-to-treatment-adherence-in-patients-with-tuberculosis-in-pereira-colombia-2012-2013
#10
Magally Dueñes, Dora Cardona
INTRODUCTION: According to the World Health Organization, the adherence to the tuberculosis treatment is the extent to which a patient's medication taking coincides with the prescribed treatment. The sum of cured patients and those who have completed treatment (directly observed therapy strategy, DOTS) are pragmatic indicators of the adherence. The patients who do not complete treatment correspond to non-adherents. Objective: To determine the relationship between anti-tuberculosis treatment adherence and socio-demographic, economic, clinical, and drug-related objective and subjective factors in patients over 18 years of age...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27622809/prevalence-of-human-t-cell-lymphotropic-virus-i-and-ii-in-colombian-blood-donors-2001-2014-implications-for-transfusion-safety
#11
María Isabel Bermúdez-Forero, Maritza Berrío-Pérez, Andrea Magally Herrera-Hernández, Magda Juliana Rodríguez-Rodríguez, Sandra García-Blanco, Guillermo Orjuela-Falla, Mauricio Beltrán
INTRODUCTION: The human T-cell lymphotropic virus (HTLV) 1 and 2 cause various clinical disorders associated with degenerative diseases. Blood transfusion is a primary mechanism of transmission that is associated with the use of cellular components such as red blood cells.  OBJECTIVE: To describe the epidemiology of HTLV 1 and 2 in blood donors in Colombia from 2001-2014.  MATERIALS AND METHODS: A retrospective analysis was performed using screening, reactivity and positivity for HTLV 1 and 2 data collected from 2001 to 2014 by Colombian blood banks and consolidated by the Instituto Nacional de Salud...
May 4, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27359616/sex-based-differences-of-six-repeated-wingate-anaerobic-cycle-test-performances-361-board-198-june-1-11-00-am-12-30-pm
#12
Nicole Liette, Kathleen S Thomas, Shannon K Crowley, Abigail J Leonard, Meir Magal
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27359392/fatigue-and-sex-based-effects-on-postural-motion-in-ncaa-division-iii-soccer-athletes-137-june-1-11-15-am-11-30-am
#13
Kathleen S Thomas, Nicole Liette, Shannon K Crowley, Abigail J Leonard, Meir Magal
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27312951/hif-1%C3%AE-and-ppar%C3%AE-during-physiological-cardiac-hypertrophy-induced-by-pregnancy-transcriptional-activities-and-effects-on-target-genes
#14
José G Soñanez-Organis, José A Godoy-Lugo, Magally L E Hernández-Palomares, Daniel Rodríguez-Martínez, Jesús A Rosas-Rodríguez, Guadalupe González-Ochoa, Adolfo Virgen-Ortiz, Rudy M Ortiz
Hypoxia inducible factor 1-α (HIF-1α) and peroxisome proliferator-activated receptor γ (PPARγ) are transcription factors that activate genes involved in cellular metabolism. Physiological cardiac hypertrophy induced by pregnancy initiates compensatory changes in metabolism. However, the contributions of HIF-1α and PPARγ to this physiological status and to its reversible, metabolic process (postpartum) in the heart are not well-defined. Therefore, the aim of the present study was to evaluate the transcriptional activities of HIF-1α and PPARγ in the left ventricle of rats before, during, and after pregnancy...
October 15, 2016: Gene
https://www.readbyqxmd.com/read/26894317/anxiety-sensitivity-among-first-time-fathers-moderates-the-relationship-between-exposure-to-stress-during-birth-and-posttraumatic-stress-symptoms
#15
Gadi Zerach, Ortal Magal
This longitudinal study examined posttraumatic stress disorder (PTSD) and anxiety symptoms among men attending the birth of their first offspring. Furthermore, we examined the moderating role of anxiety sensitivity (AS) and intolerance of uncertainty in the association between exposure to stress during birth and PTSD and anxiety symptoms. Participants were Israeli men (n = 171) who were assessed with self-report questionnaires during the third trimester of pregnancy (T1) and approximately a month following birth (T2)...
May 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/26822128/segmental-basal-cell-naevus-syndrome-caused-by-an-activating-mutation-in-smoothened
#16
Z Khamaysi, R Bochner, M Indelman, L Magal, E Avitan-Hersh, O Sarig, E Sprecher, R Bergman
Aberrant sonic hedgehog signalling, mostly due to PTCH1 mutations, has been shown to play a central role in the pathogenesis of basal cell carcinoma (BCC), as well as in basal cell naevus syndrome (BCNS). Mutations in smoothened (SMO) encoding a receptor for sonic hedgehog have been reported in sporadic BCCs but not in BCNS. We report a case with multiple BCCs, pits and comedones in a segmental distribution over the upper part of the body, along with other findings compatible with BCNS. Histopathologically, there were different types of BCC...
July 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/26544533/constitutional-mismatch-repair-deficiency-in-israel-high-proportion-of-founder-mutations-in-mmr-genes-and-consanguinity
#17
Hagit N Baris, Inbal Barnes-Kedar, Helen Toledano, Marisa Halpern, Dov Hershkovitz, Alexander Lossos, Israela Lerer, Tamar Peretz, Revital Kariv, Shlomi Cohen, Elizabeth E Half, Nurit Magal, Valerie Drasinover, Katharina Wimmer, Yael Goldberg, Dani Bercovich, Zohar Levi
BACKGROUND: Heterozygous germline mutations in any of the mismatch repair (MMR) genes, MLH1, MSH2, MSH6, and PMS2, cause Lynch syndrome (LS), an autosomal dominant cancer predisposition syndrome conferring a high risk of colorectal, endometrial, and other cancers in adulthood. Offspring of couples where both spouses have LS have a 1:4 risk of inheriting biallelic MMR gene mutations. These cause constitutional MMR deficiency (CMMRD) syndrome, a severe recessively inherited cancer syndrome with a broad tumor spectrum including mainly hematological malignancies, brain tumors, and colon cancer in childhood and adolescence...
March 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26473759/updating-acsm-s-recommendations-for-exercise-preparticipation-health-screening
#18
Deborah Riebe, Barry A Franklin, Paul D Thompson, Carol Ewing Garber, Geoffrey P Whitfield, Meir Magal, Linda S Pescatello
The purpose of the American College of Sports Medicine's (ACSM) exercise preparticipation health screening process is to identify individuals who may be at elevated risk for exercise-related sudden cardiac death and/or acute myocardial infarction. Recent studies have suggested that using the current ACSM exercise preparticipation health screening guidelines can result in excessive physician referrals, possibly creating a barrier to exercise participation. In addition, there is considerable evidence that exercise is safe for most people and has many associated health and fitness benefits; exercise-related cardiovascular events are often preceded by warning signs/symptoms; and the cardiovascular risks associated with exercise lessen as individuals become more physically active/fit...
November 2015: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/26427141/standardization-of-a-protocol-for-obtaining-platelet-rich-plasma-from-blood-donors-a-tool-for-tissue-regeneration-procedures
#19
Lina Andrea Gómez, Magally Escobar, Oscar Peñuela
BACKGROUND: To develop a protocol for obtaining autologous platelet rich plasma in healthy individuals and to determine the concentration of five major growth factors before platelet activation. This protocol could be integrated into the guidelines of good clinical practice and research in regenerative medicine. METHODS: Platelet rich plasma was isolated by centrifugation from 38 healthy men and 42 women ranging from 18 to 59 years old. The platelet count and quantification of growth factors were analyzed in eighty samples, stratified for age and gender of the donor...
2015: Clinical Laboratory
https://www.readbyqxmd.com/read/26219579/molecular-characterization-and-organ-specific-expression-of-the-gene-that-encodes-betaine-aldehyde-dehydrogenase-from-the-white-shrimp-litopenaeus-vannamei-in-response-to-osmotic-stress
#20
María F Delgado-Gaytán, Magally L E Hernández-Palomares, José G Soñanez-Organis, Adriana Muhlia-Almazán, Arturo Sánchez-Paz, Norma A Stephens-Camacho, Elisa M Valenzuela-Soto, Jesús A Rosas-Rodríguez
Crustaceans overcome osmotic disturbances by regulating their intracellular concentration of ions and osmolytes. Glycine betaine (GB), an osmolyte accumulated in response to hyperosmotic stress, is synthesized by betaine aldehyde dehydrogenase (BADH EC 1.2.1.8) through the oxidation of betaine aldehyde. A partial BADH cDNA sequence from the white shrimp Litopenaeus vannamei was obtained and its organ-specific expression during osmotic stress (low and high salinity) was evaluated. The partial BADH cDNA sequence (LvBADH) is 1103bp long and encodes an open reading frame for 217 protein residues...
November 2015: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
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