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María Isabel Bermúdez-Forero, Maritza Berrío-Pérez, Andrea Magally Herrera-Hernández, Magda Juliana Rodríguez-Rodríguez, Sandra García-Blanco, Guillermo Orjuela-Falla, Mauricio Beltrán
INTRODUCTION: The human T-cell lymphotropic virus (HTLV) 1 and 2 cause various clinical disorders associated with degenerative diseases. Blood transfusion is a primary mechanism of transmission that is associated with the use of cellular components such as red blood cells.  OBJECTIVE: To describe the epidemiology of HTLV 1 and 2 in blood donors in Colombia from 2001-2014.  MATERIALS AND METHODS: A retrospective analysis was performed using screening, reactivity and positivity for HTLV 1 and 2 data collected from 2001 to 2014 by Colombian blood banks and consolidated by the Instituto Nacional de Salud...
2016: Biomédica: Revista del Instituto Nacional de Salud
Nicole Liette, Kathleen S Thomas, Shannon K Crowley, Abigail J Leonard, Meir Magal
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Kathleen S Thomas, Nicole Liette, Shannon K Crowley, Abigail J Leonard, Meir Magal
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
José G Soñanez-Organis, José A Godoy-Lugo, Magally L E Hernández-Palomares, Daniel Rodríguez-Martínez, Jesús A Rosas-Rodríguez, Guadalupe González-Ochoa, Adolfo Virgen-Ortiz, Rudy M Ortiz
Hypoxia inducible factor 1-α (HIF-1α) and peroxisome proliferator-activated receptor γ (PPARγ) are transcription factors that activate genes involved in cellular metabolism. Physiological cardiac hypertrophy induced by pregnancy initiates compensatory changes in metabolism. However, the contributions of HIF-1α and PPARγ to this physiological status and to its reversible, metabolic process (postpartum) in the heart are not well-defined. Therefore, the aim of the present study was to evaluate the transcriptional activities of HIF-1α and PPARγ in the left ventricle of rats before, during, and after pregnancy...
October 15, 2016: Gene
Gadi Zerach, Ortal Magal
This longitudinal study examined posttraumatic stress disorder (PTSD) and anxiety symptoms among men attending the birth of their first offspring. Furthermore, we examined the moderating role of anxiety sensitivity (AS) and intolerance of uncertainty in the association between exposure to stress during birth and PTSD and anxiety symptoms. Participants were Israeli men (n = 171) who were assessed with self-report questionnaires during the third trimester of pregnancy (T1) and approximately a month following birth (T2)...
May 2016: Journal of Nervous and Mental Disease
Z Khamaysi, R Bochner, M Indelman, L Magal, E Avitan-Hersh, O Sarig, E Sprecher, R Bergman
Aberrant sonic hedgehog signalling, mostly due to PTCH1 mutations, has been shown to play a central role in the pathogenesis of basal cell carcinoma (BCC), as well as in basal cell naevus syndrome (BCNS). Mutations in smoothened (SMO) encoding a receptor for sonic hedgehog have been reported in sporadic BCCs but not in BCNS. We report a case with multiple BCCs, pits and comedones in a segmental distribution over the upper part of the body, along with other findings compatible with BCNS. Histopathologically, there were different types of BCC...
July 2016: British Journal of Dermatology
Hagit N Baris, Inbal Barnes-Kedar, Helen Toledano, Marisa Halpern, Dov Hershkovitz, Alexander Lossos, Israela Lerer, Tamar Peretz, Revital Kariv, Shlomi Cohen, Elizabeth E Half, Nurit Magal, Valerie Drasinover, Katharina Wimmer, Yael Goldberg, Dani Bercovich, Zohar Levi
BACKGROUND: Heterozygous germline mutations in any of the mismatch repair (MMR) genes, MLH1, MSH2, MSH6, and PMS2, cause Lynch syndrome (LS), an autosomal dominant cancer predisposition syndrome conferring a high risk of colorectal, endometrial, and other cancers in adulthood. Offspring of couples where both spouses have LS have a 1:4 risk of inheriting biallelic MMR gene mutations. These cause constitutional MMR deficiency (CMMRD) syndrome, a severe recessively inherited cancer syndrome with a broad tumor spectrum including mainly hematological malignancies, brain tumors, and colon cancer in childhood and adolescence...
March 2016: Pediatric Blood & Cancer
Deborah Riebe, Barry A Franklin, Paul D Thompson, Carol Ewing Garber, Geoffrey P Whitfield, Meir Magal, Linda S Pescatello
The purpose of the American College of Sports Medicine's (ACSM) exercise preparticipation health screening process is to identify individuals who may be at elevated risk for exercise-related sudden cardiac death and/or acute myocardial infarction. Recent studies have suggested that using the current ACSM exercise preparticipation health screening guidelines can result in excessive physician referrals, possibly creating a barrier to exercise participation. In addition, there is considerable evidence that exercise is safe for most people and has many associated health and fitness benefits; exercise-related cardiovascular events are often preceded by warning signs/symptoms; and the cardiovascular risks associated with exercise lessen as individuals become more physically active/fit...
November 2015: Medicine and Science in Sports and Exercise
Lina Andrea Gómez, Magally Escobar, Oscar Peñuela
BACKGROUND: To develop a protocol for obtaining autologous platelet rich plasma in healthy individuals and to determine the concentration of five major growth factors before platelet activation. This protocol could be integrated into the guidelines of good clinical practice and research in regenerative medicine. METHODS: Platelet rich plasma was isolated by centrifugation from 38 healthy men and 42 women ranging from 18 to 59 years old. The platelet count and quantification of growth factors were analyzed in eighty samples, stratified for age and gender of the donor...
2015: Clinical Laboratory
María F Delgado-Gaytán, Magally L E Hernández-Palomares, José G Soñanez-Organis, Adriana Muhlia-Almazán, Arturo Sánchez-Paz, Norma A Stephens-Camacho, Elisa M Valenzuela-Soto, Jesús A Rosas-Rodríguez
Crustaceans overcome osmotic disturbances by regulating their intracellular concentration of ions and osmolytes. Glycine betaine (GB), an osmolyte accumulated in response to hyperosmotic stress, is synthesized by betaine aldehyde dehydrogenase (BADH EC through the oxidation of betaine aldehyde. A partial BADH cDNA sequence from the white shrimp Litopenaeus vannamei was obtained and its organ-specific expression during osmotic stress (low and high salinity) was evaluated. The partial BADH cDNA sequence (LvBADH) is 1103bp long and encodes an open reading frame for 217 protein residues...
November 2015: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Ran Rosen, Surapathrudu Kanakala, Adi Kliot, Britto Cathrin Pakkianathan, Basheer Abu Farich, Nadine Santana-Magal, Meytar Elimelech, Svetlana Kontsedalov, Galina Lebedev, Michelle Cilia, Murad Ghanim
Begomoviruses comprise an emerging and economically important group of plant viruses exclusively transmitted by the sweetpotato whitefly Bemisia tabaci in many regions of the world. The past twenty years have witnessed significant progress in studying the molecular interactions between members of this virus group and B. tabaci. Mechanisms and proteins encoded by the insect vector and its bacterial symbionts, which have been shown to be important for virus transmission, have been identified and thoroughly studied...
December 2015: Current Opinion in Virology
Luisa F Posada-Uribe, Magally Romero-Tabarez, Valeska Villegas-Escobar
Bacillus subtilis spores have important biotechnological applications; however, achieving both, high spore cell densities and sporulation efficiencies in fermentation, is poorly reported. In this study, medium components and culture conditions were optimized with different statistical methods to increase spore production of the plant growth promoting rhizobacteria B. subtilis EA-CB0575. Key medium components were determined with Plackett-Burman (PB) design, and the optimum concentration levels of two components (glucose, MgSO4·7H2O) were optimized with a full factorial and central composite design, achieving 1...
October 2015: Bioprocess and Biosystems Engineering
Peter Hinow, Pierre Magal, Shigui Ruan
This special issue is dedicated to the 70th birthday of Glenn F. Webb. The topics of the 12 articles appearing in this special issue include evolutionary dynamics of population growth, spatio-temporal dynamics in reaction-diffusion biological models, transmission dynamics of infectious diseases, modeling of antibiotic-resistant bacteria in hospitals, analysis of Prion models, age-structured models in ecology and epidemiology, modeling of immune response to infections, modeling of cancer growth, etc. These topics partially represent the broad areas of Glenn's research interest...
August 2015: Mathematical Biosciences and Engineering: MBE
Lina Basel-Vanagaite, Pola Smirin-Yosef, Jenna Lee Essakow, Shay Tzur, Irina Lagovsky, Idit Maya, Metsada Pasmanik-Chor, Adva Yeheskel, Osnat Konen, Naama Orenstein, Monika Weisz Hubshman, Valerie Drasinover, Nurit Magal, Gaby Peretz Amit, Yael Zalzstein, Avraham Zeharia, Mordechai Shohat, Rachel Straussberg, Didier Monté, Mali Salmon-Divon, Doron M Behar
Genetic syndromes involving both brain and eye abnormalities are numerous and include syndromes such as Warburg micro syndrome, Kaufman oculocerebrofacial syndrome, Cerebro-oculo-facio-skeletal syndrome, Kahrizi syndrome and others. Using exome sequencing, we have been able to identify homozygous mutation p.(Tyr39Cys) in MED25 as the cause of a syndrome characterized by eye, brain, cardiac and palatal abnormalities as well as growth retardation, microcephaly and severe intellectual disability in seven patients from four unrelated families, all originating from the same village...
June 2015: Human Genetics
Meir Magal, Rebekah J Cain, Josh C Long, Kathleen S Thomas
Pre-practice euhydration is key in the prevention of heat related injuries. The pre-practice hydration status of male National Collegiate Athletic Association (NCAA)-Division III athletes and the effects of a direct hydration regimen have yet to be investigated therefore; the aim of the study was 1) to analyze the pre-practice hydration status of current NCAA-DIII male athletes and 2) assess the impact of a directed intervention on pre-practice hydration status. The study was divided into baseline, pre and post intervention phases...
March 2015: Journal of Sports Science & Medicine
Glenn Webb, Cameron Browne, Xi Huo, Ousmane Seydi, Moussa Seydi, Pierre Magal
A differential equations model is developed for the 2014 Ebola epidemics in Sierra Leone and Liberia. The model describes the dynamic interactions of the susceptible and infected populations of these countries. The model incorporates the principle features of contact tracing, namely, the number of contacts per identified infectious case, the likelihood that a traced contact is infectious, and the efficiency of the contact tracing process. The model is first fitted to current cumulative reported case data in each country...
2015: PLoS Currents
Roni Hogri, Simeon A Bamford, Aryeh H Taub, Ari Magal, Paolo Del Giudice, Matti Mintz
Neuroprostheses could potentially recover functions lost due to neural damage. Typical neuroprostheses connect an intact brain with the external environment, thus replacing damaged sensory or motor pathways. Recently, closed-loop neuroprostheses, bidirectionally interfaced with the brain, have begun to emerge, offering an opportunity to substitute malfunctioning brain structures. In this proof-of-concept study, we demonstrate a neuro-inspired model-based approach to neuroprostheses. A VLSI chip was designed to implement essential cerebellar synaptic plasticity rules, and was interfaced with cerebellar input and output nuclei in real time, thus reproducing cerebellum-dependent learning in anesthetized rats...
2015: Scientific Reports
Juliana Sterci da Silva, Cinira Magal Fortuna, Maria José Bistafa Pereira, Silvia Matumoto, Fabiana Ribeiro Santana, Franciele Maia Marciano, Jael Bernardes Silva, Marianna Ferreira, Silvana Martins Mishima
OBJECTIVE: Analyzing the conceptions of supervision of nurses in the Family Health Strategy (ESF - Estratégia Saúde da Família) in relation to community health workers (ACS - Agente Comunitário de Saúde), taking for reference the work process and the power relations. METHOD: A qualitative study, in which 18 interviews were carried out with nurses from the ESF in the countryside of the state of Goiás. Following transcription, the data were subjected to thematic content analysis and the following categories were identified: Supervision with that sees it all and Supervision is participating and working together...
October 2014: Revista da Escola de Enfermagem da U S P
Ari Magal, Matti Mintz
The amygdala and the cerebellum serve two distinctively different functions. The amygdala plays a role in the expression of emotional information, whereas the cerebellum is involved in the timing of discrete motor responses. Interaction between these two systems is the basis of the two-stage theory of learning, according to which an encounter with a challenging event triggers fast classical conditioning of fear-conditioned responses in the amygdala and slow conditioning of motor-conditioned responses in the cerebellum...
November 2014: European Journal of Neuroscience
Ivan Herreros, Andrea Giovannucci, Aryeh H Taub, Roni Hogri, Ari Magal, Sim Bamford, Robert Prueckl, Paul F M J Verschure
Emulating the input-output functions performed by a brain structure opens the possibility for developing neuroprosthetic systems that replace damaged neuronal circuits. Here, we demonstrate the feasibility of this approach by replacing the cerebellar circuit responsible for the acquisition and extinction of motor memories. Specifically, we show that a rat can undergo acquisition, retention, and extinction of the eye-blink reflex even though the biological circuit responsible for this task has been chemically inactivated via anesthesia...
2014: Frontiers in Bioengineering and Biotechnology
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