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Hemophilus influenza

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https://www.readbyqxmd.com/read/27650380/immunogenicity-and-protective-immunity-against-otitis-media-caused-by-pneumococcus-in-mice-of-hib-conjugate-vaccine-with-psaa-protein-carrier
#1
Zeyu Chen, Rong Guo, Jianghong Xu, Chuangjun Qiu
This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccine with the pneumococcal surface adhesin A (PsaA) protein carrier in young mice. The Hib polysaccharide was conjugated with the rPsaA protein carrier, which was produced using recombinant DNA technology. A total of 15 young mice aged 3 weeks to 5 weeks were immunized with the conjugate vaccine, and another 15 young mice of the same age were immunized with the licensed Hib-tetanus toxoid (TT) vaccine...
September 20, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27070064/understanding-bacterial-isolates-in-blood-culture-and-approaches-used-to-define-bacteria-as-contaminants-a-literature-review
#2
Belal Hossain, Mohammad Shahidul Islam, Atiqur Rahman, Mahfuza Marzan, Iftekhar Rafiqullah, Nicholas E Connor, Mohammad Hasanuzzaman, Maksuda Islam, Davidson H Hamer, Patricia L Hibberd, Samir K Saha
BACKGROUND: Interpretation of blood culture isolates is challenging due to a lack of standard methodologies for identifying contaminants. This problem becomes more complex when the specimens are from sick young infants, as a wide range of bacteria can cause illness among this group. METHODS: We used 43 key words to find articles published between 1970 and 2011 on blood culture isolates and possible contaminants in the PubMed database. Experts were also consulted to obtain other relevant articles...
May 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27029685/bacterial-pathogens-associated-with-community-acquired-pneumonia-in-children-aged-below-five-years
#3
Anusmita Das, Saurav J Patgiri, Lahari Saikia, Pritikar Dowerah, Reema Nath
OBJECTIVE: To determine the spectrum of bacterial pathogens causing community-acquired pneumonia in children below 5 years of age. METHODS: Children aged below 5 years satisfying the WHO criteria for pneumonia, severe pneumonia or very severe pneumonia, and with the presence of lung infiltrates on chest X-ray were enrolled. Two respiratory samples, one for culture and the other for PCR analysis, and a blood sample for culture were collected from every child. RESULTS: Of the 180 samples processed, bacterial pathogens were detected in 64...
March 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/26632723/good-s-syndrome-patients-hospitalized-for-infections-a-single-center-retrospective-study
#4
Xuefeng Sun, Juhong Shi, Mengzhao Wang, Kaifeng Xu, Yi Xiao
Good's syndrome (GS) is a rare combination of thymoma and hypogammaglobulinemia, resulting in immunodeficiency. Patients with GS are highly susceptible to bacterial infection, particularly encapsulated bacterial infection in upper and lower respiratory tracts. Good's syndrome patients with moderate-to- severe infection are often hospitalized. Clinical features of GS patients remain to be characterized.Patients with the discharge diagnosis of GS and simultaneous infection from Peking Union Medical College Hospital between January 2001 and July 2015 were retrospectively analyzed...
November 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26299087/hemophilus-influenzae-infections-with-abscess-formation-in-adults-a-retrospective-study-covering-an-eleven-year-period
#5
Muzeyyen Mamal Torun, Hrisi Bahar Tokman, Mehmet Demirci, Sinem Ozdemir, Serdar M Altinkum, Hatice Cilingir, Filiz Yarimcam Saglam
BACKGROUND: The aim of this study was to investigate the presence of Haemophilus influenzae in abscesses in adults and to determine their antibiotic resistance patterns. METHODS: H. influenzae strains isolated from abscesses during an eleven-year period were determined retrospectively and the stored strains were tested for ampicillin, amoxicillin/calvulanic acid, cefuroxime, cefotaxime, ceftriaxone, ciprofloxacin, azithromycin, tetracycline, and imipenem resistance by broth microdilution method...
2015: Clinical Laboratory
https://www.readbyqxmd.com/read/26266696/erythema-multiforme-associated-with-respiratory-disease-in-a-commercial-breeding-pig-herd
#6
Vasileios G Papatsiros, Labrini V Athanasiou, Dimitra Psalla, Evanthia Petridou, Giorgos G Maragkakis, Ioannis Papatsas, Ioannis Arsenakis, Dominiek Maes
This study describes an erythema multiforme (EM) in breeding sows, after their mixing in the group housing system. Sows at 30-35 days of gestation showed red and raised skin areas, depression, anorexia, fever, respiratory problems, and increased return to estrus. Blood and nasal samples from diseased sows were examined by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay for respiratory pathogens. Hematological and biochemical analyses were performed on the blood samples. From diseased sows, vaginal swabs for microbiological examinations and samples at slaughterhouse for gross and microscopic examinations were collected...
October 2015: Viral Immunology
https://www.readbyqxmd.com/read/26163332/patient-education-and-recall-regarding-postsplenectomy-immunizations
#7
Gerald P Kealey, Vinayak Dhungel, Matthew J Wideroff, Junlin Liao, Kent Choi, Dionne A Skeete, Michele A Lilienthal, Janelle Born, Graeme Pitcher
BACKGROUND: The purpose of this study was to determine the rates of initial vaccinations after splenectomy for trauma, assess the effectiveness of patient education on reimmunizations, and evaluate patients' utilization of their knowledge regarding immunization after discharge. METHODS: From June 1996-December 2011, 144 patients underwent splenectomy after traumatic injury. A telephone survey was completed in 100 of 144 splenectomized patients (69%) at a mean of 7...
December 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/25973941/pathogenic-bacterial-nasopharyngeal-colonization-and-its-impact-on-respiratory-diseases-in-the-first-year-of-life-the-patch-birth-cohort-study
#8
Ming-Han Tsai, Shu-Huan Huang, Chyi-Liang Chen, Chih-Yung Chiu, Man-Chin Hua, Sui-Ling Liao, Tsung-Chieh Yao, Shen-Hao Lai, Kuo-Wei Yeh, Mei-Ping Wang, Jing-Long Huang
BACKGROUND: For acute respiratory diseases caused by bacteria, colonization in the respiratory tracts is often the first sign, although nasopharynx is the major source of secretions containing pathogens. To understand the pathogenesis of respiratory tract diseases, it is important to analyze the establishment of nasopharyngeal bacterial colonization. METHODS: Infants with nasopharyngeal swabs were examined at the age of 1, 2, 4, 6 and 12 months for the detection of pathogens, including Streptococcus pneumoniae, Hemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes and Staphylococcus aureus...
June 2015: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/25810981/four-new-vaccines-for-routine-immunization-in-india-what-about-hemophilus-influenza-b-and-pneumococcal-vaccine
#9
Sourabh Paul, Jyotiranjan Sahoo
Immunization is the process whereby a person is made immune or resistant to an infectious disease, typically by the administration of a vaccine. The Expanded Program on Immunization (EPI) was flagged off in India in 1978. According to the recommendation of National technical advisory group of India (NATGI), Government of India is going to include four new vaccines in the UIP for whole India. The four new vaccines are Inactivated Poliomyelitis Vaccine (IPV) for polio, rota viral vaccine, vaccine against rubella, and Japanese encephalitis vaccine (179 districts in India)...
January 2015: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/25772909/immunization-status-of-internationally-adopted-children-in-rome-italy
#10
H K Tchidjou, L Gargiullo, F Vescio, R Giampaolo, L Nicolosi, A Finocchi, P Rossi
AIMS: International adoption medicine is a relatively new specialty in pediatrics that has emerged to address the specific health care needs of internationally adopted children in high-income countries. This study ascertains the seroprotection rate for vaccine-preventable diseases, especially against pneumococcal diseases. PATIENTS AND METHODS: We evaluated 67 internationally adopted children that reached the International Adoption Unit of Bambino Gesù Children's Hospital, Rome-Italy...
May 2015: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/25560025/hemophilus-influenzae-meningitis-and-septicaemia-in-a-14-month-old-child-after-primary-immunisation
#11
B Tarai, N Ravishankar, P Vohra, P Das
We report a 14-month-male child, who developed Hemophilus influenzae meningitis after three primary doses of the vaccine. The child presented with fever and seizures. H. influenzae was isolated from both cerebrospinal fluid (CSF) and blood. The child also had features of septicaemia. Procalcitonin (104 ng/ml) and C-reactive protein (CRP--42.6 mg/dl) were high. Appropriate antibiotics were given. The child made an uneventful recovery. This case highlights vaccine failure, especially after primary immunisation alone...
January 2015: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/25520829/a-case-of-purpura-fulminans-caused-by-hemophilus-influenzae-complicated-by-reversible-cardiomyopathy
#12
Akira Endo, Atsushi Shiraishi, Junichi Aiboshi, Yoshiro Hayashi, Yasuhiro Otomo
Here, we report a case of a 41-year-old male diagnosed as septic shock with purpura fulminans (PF) infection. The causative organism was β-lactamase-negative ampicillin-resistant Hemophilus influenzae. He developed fulminant cardiac dysfunction approximately 1 h after admission, and the cause was considered to be septic cardiomyopathy. Blood pressure and oxygenation were maintained at adequate levels with the aid of extracorporeal membrane oxygenation (ECMO). The cardiac dysfunction was reversible, and he was successfully weaned from ECMO on day 12 of hospitalization...
2014: Journal of Intensive Care
https://www.readbyqxmd.com/read/25483494/use-of-immuno-assays-during-the-development-of-a-hemophilus-influenzae-type-b-vaccine-for-technology-transfer-to-emerging-vaccine-manufacturers
#13
Ahd Hamidi, Hans Kreeftenberg
Quality control of Hemophilus Influenzae type b (Hib) conjugate vaccines is mainly dependent on physicochemical methods. Overcoming sample matrix interference when using physicochemical tests is very challenging, these tests are therefore only used to test purified samples of polysaccharide, protein, bulk conjugate, and final product. For successful development of a Hib conjugate vaccine, several ELISA (enzyme-linked immunosorbent assay) methods were needed as an additional tool to enable testing of in process (IP) samples...
2014: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/25483487/meningitis-caused-by-neisseria-meningitidis-hemophilus-influenzae-type-b-and-streptococcus-pneumoniae-during-2005-2012-in-turkey-a-multicenter-prospective-surveillance-study
#14
MULTICENTER STUDY
Mehmet Ceyhan, Nezahat Gürler, Yasemin Ozsurekci, Melike Keser, Ahmet Emre Aycan, Venhar Gurbuz, Nuran Salman, Yildiz Camcioglu, Ener Cagri Dinleyici, Sengul Ozkan, Gulnar Sensoy, Nursen Belet, Emre Alhan, Mustafa Hacimustafaoglu, Solmaz Celebi, Hakan Uzun, Ahmet Faik Oner, Zafer Kurugol, Mehmet Ali Tas, Denizmen Aygun, Eda Karadag Oncel, Melda Celik, Olcay Yasa, Fatih Akin, Yavuz Coşkun
Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology of bacterial meningitis. Cerebrospinal fluid (CSF) samples were obtained prospectively from children from 1 month to ≤18 years of age hospitalized with suspected meningitis, in order to determine the etiology of meningitis in Turkey. DNA evidence of Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumoniae), and Hemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR)...
2014: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/25214656/effects-of-a-pharmacy-driven-perisplenectomy-vaccination-program-on-vaccination-rates-and-adherence-to-guidelines
#15
Vanessa Meier-Stephenson, Shelly McNeil, Andrea Kew, Jennifer Sweetapple, Kara Thompson, Kathryn Slayter
BACKGROUND: Overwhelming postsplenectomy infection is a serious potential outcome for patients who have undergone resection of the spleen and is associated with a high mortality rate. The most common bacterial causes are the encapsulated organisms Streptococcus pneumoniae, Neisseria meningitidis, and Hemophilus influenzae type B, all of which are vaccine-preventable. Current guidelines recommend vaccination against these 3 bacteria, but adherence to these guidelines is less than ideal...
July 2014: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/25124395/supraglottitis-due-to-group-b-streptococcus-in-an-adult-with-igg4-and-c2-deficiency-a-case-report-and-review-of-the-literature
#16
REVIEW
Vinayak Nagaraja, Thomas E Stewart, Stuart G Mackay, Derek W Glenn, Denis Wakefield, Craig S Boutlis
Acute supraglottitis is a medical emergency as it can rapidly lead to airway compromise. With routine pediatric immunization for Hemophilus influenzae serotype b, supraglottitis is now more prevalent in adults, with a shift in the causative organisms and a change in the natural history of this disease. Here, we present a case of supraglottitis due to group B streptococcus that occurred in an adult with previously undetected immunoglobulin 4 (IgG4) and complement protein C2 deficiency.
April 2015: Laryngoscope
https://www.readbyqxmd.com/read/25087311/-infant-pain-response-according-to-vaccine-administration
#17
RANDOMIZED CONTROLLED TRIAL
María del Prado Sánchez-Molero Martín, Ana María del Cerro Gutiérrez, Herminia Galán Delgado, Juan Carlos Muñoz Camargo
OBJECTIVE: To determine if acute pain response in infants after administration of pentavalent diphtheria (polio, tetanus, acellular pertussis and B Type Hemophilus influenzae: Pentavac) and meningitis C vaccine (NeisVacC) vary according to the administration order. METHOD: A multicenter, randomized control trial, double-blind was performed in three pediatric nursing consultations of three healthcare centers between December 2010, and December 2011. Two months healthy children in subjected to a routine immunization...
June 2014: Revista de Enfermería
https://www.readbyqxmd.com/read/25044339/the-biofilm-matrix-destabilizers-edta-and-dnasei-enhance-the-susceptibility-of-nontypeable-hemophilus-influenzae-biofilms-to-treatment-with-ampicillin-and-ciprofloxacin
#18
Rosalia Cavaliere, Jessica L Ball, Lynne Turnbull, Cynthia B Whitchurch
Nontypeable Hemophilus influenzae (NTHi) is a Gram-negative bacterial pathogen that causes chronic biofilm infections of the ears and airways. The biofilm matrix provides structural integrity to the biofilm and protects biofilm cells from antibiotic exposure by reducing penetration of antimicrobial compounds into the biofilm. Extracellular DNA (eDNA) has been found to be a major matrix component of biofilms formed by many species of Gram-positive and Gram-negative bacteria, including NTHi. Interestingly, the cation chelator ethylenediaminetetra-acetic acid (EDTA) has been shown to reduce the matrix strength of biofilms of several bacterial species as well as to have bactericidal activity against various pathogens...
August 2014: MicrobiologyOpen
https://www.readbyqxmd.com/read/25023084/prevalence-of-sickle-cell-disease-in-a-pediatric-population-suffering-from-severe-infections-a-congolese-experience
#19
Diane A Kondani, Jean Lambert Gini-Ehungu, Joseph M Bodi, Pépé M Ekulu, Thomas S Kunuanunua, Michel N Aloni
Neonatal screening for sickle cell anemia is not a common practice in the Democratic Republic of Congo (DRC). Children with sickle cell disease are known to have an increased risk of infections. We conducted a pilot study to determine the prevalence of sickle cell anemia during episodes of severe infection. A prospective study was conducted from July 2009 to July 2011. The study sites included four public hospitals at Kinshasa, DRC. The study population was selected from the source population using three-stage sampling...
2014: Hemoglobin
https://www.readbyqxmd.com/read/24786644/the-capita-study-of-protein-conjugate-pneumococcal-vaccine-and-its-implications-for-use-in-adults-in-developed-countries
#20
REVIEW
Daniel M Musher, Maria C Rodriguez-Barradas
Until 1990, Hemophilus influenzae type b (HITB) was a major cause of morbidity and mortality in toddlers and young children. A vaccine consisting of purified polyribosyl ribitol phosphate (PRP), the capsular polysaccharide (CPS) of HITB, had been shown to be ineffective as an antigen in the population at risk, and this vaccine was withdrawn from the market within a few years of its introduction. By contrast, the discovery that PRP, when covalently bound to an antigenic protein, stimulated antibody production in infants and toddlers, (1) led to the development of a vaccine that has all but eradicated HITB infection and brought about a near-disappearance of this organism in the United States...
2014: Human Vaccines & Immunotherapeutics
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