keyword
MENU ▼
Read by QxMD icon Read
search

Strep pneumoniae

keyword
https://www.readbyqxmd.com/read/28928442/genome-wide-association-and-hla-region-fine-mapping-studies-identify-susceptibility-loci-for-multiple-common-infections
#1
Chao Tian, Bethann S Hromatka, Amy K Kiefer, Nicholas Eriksson, Suzanne M Noble, Joyce Y Tung, David A Hinds
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28869231/how-a-mild-influenza-b-infection-can-kill-a-case-of-pulmonary-hemorrhage
#2
Nathalie Abi Hatem, Sabrina Campbell, Deepa Kuchelan, Jennifer Bowers, Edmundo Rubio
Viral influenza is a seasonal infection associated with significant morbidity and mortality. Rapidly fatal hemorrhagic pneumonia has been described in previously healthy individuals with β-hemolytic Streptococcus pneumoniae in a small series of patients, but it is not common in patients coinfected with influenza B and β-hemolytic Streptococcus, particularly since influenza B is considered less pathogenic than influenza A. However, despite being uncommon, this coinfection seems to be associated with high morbidity and mortality, particularly in healthy individuals...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28859019/age-specific-antibiotic-prescribing-and-adherence-to-guidelines-in-pediatric-patients-in-primary-care
#3
Verica Ivanovska, Karin Hek, Aukje K Mantel-Teeuwisse, Hubert G M Leufkens, Liset van Dijk
BACKGROUND: Most antibiotics in children are used to treat viral and self-limiting conditions. This study aims to compare physicians' adherence to guidelines on antibiotic prescribing in fever and in ear and respiratory infections to children in different age groups in the Netherlands. METHODS: Data were used from the NIVEL Primary Care Database. For all pediatric episodes of fever, acute otitis media (AOM), streptococcal pharyngitis (strep throat), sinusitis, acute tonsillitis, acute bronchitis/bronchiolitis and pneumonia in 2012, we determined whether national guidelines were followed in regard to whether an antibiotic was prescribed, and the type of antibiotic...
August 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28569141/disease-burden-and-antimicrobial-resistance-of-invasive-group-b-streptococcus-among-infants-in-china-a-protocol-for-a-national-prospective-observational-study
#4
Wenjing Ji, Haiying Liu, Zhengjiang Jin, Aimin Wang, Xiaoping Mu, Xiaosong Qin, Weidong Wang, Chunyan Gao, Yuning Zhu, Xiaodan Feng, Jine Lei, Shangyang She, Lan Jiang, Jing Liu, Shuhua Yang, Zeshi Liu, Gang Li, Qiuhong Li, Dawen Guo, Muhammad Majid Aziz, Ali Hassan Gillani, Yu Fang
BACKGROUND: Group B Streptococcus (GBS) is a cause of neonatal sepsis, pneumonia, and meningitis that can lead to neurological sequelae in infants less than 3 months of age. The GBS disease burden is not known in China, therefore it cannot receive major attention. The main objectives of this study are the evaluation of the incidence of neonatal GBS infection, GBS case-fatality ratio, its serotypes and genotypes, bacterial resistance, clinical treatment and outcomes in China. METHODS: We are conducting a nation-wide, population-based, multi-center, prospective, observational cohort study in China from May 2016 to December 2017...
May 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28562551/final-diagnoses-and-probability-of-new-reason-for-encounter-at-an-urban-clinic-in-japan-a-4-year-observational-study
#5
Motoharu Fukushi, Yukishige Ishibashi, Naoki Nago
Past clinical data are not currently used to calculate pretest probabilities, as they have not been put into a database in clinical settings. This observational study was designed to determine the initial reasons for utilizing home visits or visits to an outpatient urban clinic in Japan.All family medical clinic outpatients and patients visited by the clinic (total = 11,688) over 1460 days were enrolled.We used a Bayes theorem-based clinical decision support system to analyze codes for initial reason-for-encounter (examination and final diagnosis: pretest probability) and final diagnosis of patients with fever (conditional pretest probability)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28292304/design-and-implementation-of-electronic-health-record-integrated-clinical-prediction-rules-icpr-a-randomized-trial-in-diverse-primary-care-settings
#6
David A Feldstein, Rachel Hess, Thomas McGinn, Rebecca G Mishuris, Lauren McCullagh, Paul D Smith, Michael Flynn, Joseph Palmisano, Gheorghe Doros, Devin Mann
BACKGROUND: Clinical prediction rules (CPRs) represent a method of determining individual patient risk to help providers make more accurate decisions at the point of care. Well-validated CPRs are underutilized but may decrease antibiotic overuse for acute respiratory infections. The integrated clinical prediction rules (iCPR) study builds on a previous single clinic study to integrate two CPRs into the electronic health record and assess their impact on practice. This article discusses study design and implementation of a multicenter cluster randomized control trial of the iCPR clinical decision support system, including the tool adaptation, usability testing, staff training, and implementation study to disseminate iCPR at multiple clinical sites across two health care systems...
March 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28138890/adult-atopic-dermatitis-with-comorbid-atopic-disease-is-associated-with-increased-risk-of-infections-a-population-based-cross-sectional-study
#7
Saisindhu Narala, Tissa R Hata
INTRODUCTION: Atopic dermatitis (AD) is related to other atopic diseases asthma and allergic rhinitis. It is known that those with asthma or allergic rhinitis have impaired immune responses that may predispose them to infections. This study sought to determine whether adult AD is associated with systemic infections, and whether association is strengthened in those with AD plus another atopic disease. METHODS: This cross-sectional study obtained information from adults in the 2010 and the 2012 National Health Interview Survey (NHIS)...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27695674/characteristics-of-mucoid-streptococcus-pyogenes-isolated-from-two-patients-with-pneumonia-in-a-local-community
#8
Nobuaki Mori, Sakiko Hosoo, Yoshitaka Oyamada, Yasushi Sera, Yasuhiro Yamada, Momoko Sugawara, Akiko Higuchi, Yasuko Aoki, Takashi Takahashi
Streptococcus pyogenes (Group A Streptococcus, GAS) infections can develop into life-threatening disorders. However, the occurrence of some GAS pneumonia cases is relatively rare in a local community. We report here characteristics of mucoid GAS isolates obtained from the sputum of two patients with pneumonia in a local community. Although case-patients did not have contact with each other, case-patient 1's child and case-patient 2's grandchild attended the same kindergarten where a GAS pharyngitis epidemic had occurred...
2016: IDCases
https://www.readbyqxmd.com/read/26388182/novel-antimicrobial-superporous-cross-linked-chitosan-pyromellitimide-benzoyl-thiourea-hydrogels
#9
Nadia A Mohamed, Nahed A Abd El-Ghany, Mona M Fahmy
In this work, chitosan (CS) was cross-linked with different amounts of pyromellitimide benzoyl thiourea moieties. The structure of the cross-linked CS was confirmed by elemental analyses, FTIR and (1)H- NMR spectroscopy. The cross-linking process proceeds via reacting of the amino groups of CS with the isothiocyanate groups of the N,N'-bis [4-(isothiocyanate carbonyl)phenyl] pyromellitimide cross-linker. The amount of the cross-linker was varied with respect to CS to produce four new pyromellitimide benzoyl thiourea cross-linked CS (PIBTU-CS) hydrogels designated as PIBTU-CS-1, PIBTU-CS-2, PIBTU-CS-3, and PIBTU-CS-4 of increasing cross-linking degree percent of 11, 22, 44 and 88%, respectively...
January 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/26387622/pulmonary-dry-powder-vaccine-of-pneumococcal-antigen-loaded-nanoparticles
#10
Nitesh K Kunda, Iman M Alfagih, Eliane N Miyaji, Douglas B Figueiredo, Viviane M Gonçalves, Daniela M Ferreira, Sarah R Dennison, Satyanarayana Somavarapu, Gillian A Hutcheon, Imran Y Saleem
Pneumonia, caused by Streptococcus pneumoniae, mainly affects the immunocompromised, the very young and the old, and remains one of the leading causes of death. A steady rise in disease numbers from non-vaccine serotypes necessitates a new vaccine formulation that ideally has better antigen stability and integrity, does not require cold-chain and can be delivered non-invasively. In this study, a dry powder vaccine containing an important antigen of S. pneumoniae, pneumococcal surface protein A (PspA) that has shown cross-reactivity amongst serotypes to be delivered via the pulmonary route has been formulated...
November 30, 2015: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26383585/1918-pandemic-influenza-virus-and-streptococcus-pneumoniae-co-infection-results-in-activation-of-coagulation-and-widespread-pulmonary-thrombosis-in-mice-and-humans
#11
Kathie-Anne Walters, Felice D'Agnillo, Zong-Mei Sheng, Jason Kindrachuk, Louis M Schwartzman, Rolf E Kuestner, Daniel S Chertow, Basil T Golding, Jeffery K Taubenberger, John C Kash
To study bacterial co-infection following 1918 H1N1 influenza virus infection, mice were inoculated with the 1918 influenza virus, followed by Streptococcus pneumoniae (SP) 72 h later. Co-infected mice exhibited markedly more severe disease, shortened survival time and more severe lung pathology, including widespread thrombi. Transcriptional profiling revealed activation of coagulation only in co-infected mice, consistent with the extensive thrombogenesis observed. Immunohistochemistry showed extensive expression of tissue factor (F3) and prominent deposition of neutrophil elastase on endothelial and epithelial cells in co-infected mice...
January 2016: Journal of Pathology
https://www.readbyqxmd.com/read/26381422/a-reference-broth-microdilution-method-for-dalbavancin-in-vitro-susceptibility-testing-of-bacteria-that-grow-aerobically
#12
Laura M Koeth, Jeanna M DiFranco-Fisher, Sandra McCurdy
Antimicrobial susceptibility testing (AST) is performed to assess the in vitro activity of antimicrobial agents against various bacteria. The AST results, which are expressed as minimum inhibitory concentrations (MICs) are used in research for antimicrobial development and monitoring of resistance development and in the clinical setting for antimicrobial therapy guidance. Dalbavancin is a semi-synthetic lipoglycopeptide antimicrobial agent that was approved in May 2014 by the Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections caused by Gram-positive organisms...
September 9, 2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26380331/facklamia-species-and-streptococcus-pneumoniae-meningitis-a-case-report-and-review-of-the-literature
#13
Kesav C Parvataneni, Sugantha Iyer, Riad Khatib, Louis D Saravolatz
Facklamia sp are Gram-positive cocci that are often mistaken for viridans streptococci, but they rarely cause invasive disease. In this report, we describe a case of mixed Facklamia sp and Streptococcus pneumoniae meningitis in an immunocompetent host with sinusitis. This case demonstrates that Facklamia sp may be part of normal human flora but can be associated with invasive disease.
April 2015: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/26379907/molecular-analysis-of-biofilms-on-the-surface-of-neonatal-endotracheal-tubes-based-on-16s-rrna-pcr-dgge-and-species-specific-pcr
#14
Hongdong Li, Chao Song, Dong Liu, Qing Ai, Jialin Yu
Ventilator-associated pneumonia (VAP) results in considerable morbidity and mortality in neonatal intensive care units. VAP is associated with polymicrobial biofilms that form on endotracheal tubes (ETTs). We aimed to evaluate the diversity and the bacterial community in biofilms on ETTs extubated from mechanically ventilated newborns. ETTs (N = 29) and aerobic sputum cultures were obtained from 20 mechanically ventilated newborns. Denaturing gradient gel electrophoresis (DGGE) was used to characterize the bacterial species in the biofilms on the ETTs...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26379256/characterizing-the-conformational-dynamics-of-metal-free-psaa-using-molecular-dynamics-simulations-and-electron-paramagnetic-resonance-spectroscopy
#15
Evelyne Deplazes, Stephanie L Begg, Jessica H van Wonderen, Rebecca Campbell, Bostjan Kobe, James C Paton, Fraser MacMillan, Christopher A McDevitt, Megan L O'Mara
Prokaryotic metal-ion receptor proteins, or solute-binding proteins, facilitate the acquisition of metal ions from the extracellular environment. Pneumococcal surface antigen A (PsaA) is the primary Mn(2+)-recruiting protein of the human pathogen Streptococcus pneumoniae and is essential for its in vivo colonization and virulence. The recently reported high-resolution structures of metal-free and metal-bound PsaA have provided the first insights into the mechanism of PsaA-facilitated metal binding. However, the conformational dynamics of metal-free PsaA in solution remain unknown...
December 2015: Biophysical Chemistry
https://www.readbyqxmd.com/read/26379004/the-etiology-of-lower-respiratory-tract-infections-in-people-with-diabetes
#16
REVIEW
Renata Barbara Klekotka, Elżbieta Mizgała, Wojciech Król
Patients with diabetes mellitus (DM) are likely to develop many types of infections, which affect the transport of glucose into tissues. Diabetes increases the susceptibility to different kinds of respiratory infections, is often identified as an independent risk factor for developing lower respiratory tract infections. Pulmonary infections caused by Mycobacterium tuberculosis, Staphylococcus aureus, gram-negative bacteria and fungi may occur with an increased frequency, whereas infections due to Streptococcus pneumonia or influenza virus may be associated with increased morbidity and mortality...
2015: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/26378458/autophosphorylation-of-the-bacterial-tyrosine-kinase-cpsd-connects-capsule-synthesis-with-the-cell-cycle-in-streptococcus-pneumoniae
#17
Julien Nourikyan, Morten Kjos, Chryslène Mercy, Caroline Cluzel, Cécile Morlot, Marie-Francoise Noirot-Gros, Sébastien Guiral, Jean-Pierre Lavergne, Jan-Willem Veening, Christophe Grangeasse
Bacterial capsular polysaccharides (CPS) are produced by a multi-protein membrane complex, in which a particular type of tyrosine-autokinases named BY-kinases, regulate their polymerization and export. However, our understanding of the role of BY-kinases in these processes remains incomplete. In the human pathogen Streptococcus pneumoniae, the BY-kinase CpsD localizes at the division site and participates in the proper assembly of the capsule. In this study, we show that the cytoplasmic C-terminal end of the transmembrane protein CpsC is required for CpsD autophosphorylation and localization at mid-cell...
September 2015: PLoS Genetics
https://www.readbyqxmd.com/read/26377931/aromatic-esters-of-bicyclic-amines-as-antimicrobials-against-streptococcus-pneumoniae
#18
María de Gracia Retamosa, Roberto Díez-Martínez, Beatriz Maestro, Esther García-Fernández, Bas de Waal, E W Meijer, Pedro García, Jesús M Sanz
A double approach was followed in the search of novel inhibitors of the surface choline-binding proteins (CBPs) of Streptococcus pneumoniae (pneumococcus) with antimicrobial properties. First, a library of 49 rationally-designed esters of alkyl amines was screened for their specific binding to CBPs. The best binders, being esters of bicyclic amines (EBAs), were then tested for their in vitro effect on pneumococcal growth and morphology. Second, the efficiency of EBA-induced CBP inhibition was enhanced about 45,000-fold by multivalency effects upon synthesizing a poly(propylene imine) dendrimer containing eight copies of an atropine derivative...
November 9, 2015: Angewandte Chemie
https://www.readbyqxmd.com/read/26376306/the-gene-polymorphism-of-il-17-g-152a-is-associated-with-increased-colonization-of-streptococcus-pneumoniae-in-young-finnish-children
#19
Juho Vuononvirta, Ville Peltola, Jorma Ilonen, Jussi Mertsola, Qiushui He
BACKGROUND: Streptococcus pneumoniae is a common respiratory pathogen, and up to 50% of children acquire S. pneumoniae in their nasopharynx during the first 12 months of life. The cytokine interleukin-17A (IL-17A) plays an important role in host defense against extracellular bacterial pathogens. We investigated the effect of IL-17 G-152A polymorphism on pneumococcal colonization in children. METHODS: Nasopharyngeal swabs and blood samples were collected from healthy Finnish children at 2...
September 2015: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26375788/macrolides-and-respiratory-infection-in-critically-ill-patients-what-is-the-next-step
#20
Thiago Lisboa, Jorge I F Salluh, Gilberto Friedman
Several observational studies as well as experimental data suggest that the use of macrolides is associated with better outcomes in patients with severe pneumonia. In severe community acquired pneumonia (SCAP), data demonstrate a benefit of combination therapy, including a beta-lactam plus a macrolide or floroquinolone, at least in the subgroup of patients with critical disease. Such combination seems to have a more significant impact in those with increased disease severity, particularly in those presenting with shock...
February 2016: Minerva Anestesiologica
keyword
keyword
61988
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"