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https://www.readbyqxmd.com/read/28432833/cellular-and-humoral-immunity-after-vaccination-or-natural-infection-of-mumps
#1
Kihei Terada, Kimiko Hagihara, Tomohiro Oishi, Ippei Miyata, Hiroto Akaike, Satoko Ogita, Naoki Ohno, Kazunobu Ouchi
OBJECTIVE: This study measured cell-mediated immunity (CMI) and serum antibody levels to clarify the basis of breakthrough after vaccination and reinfection after mumps. METHODS: From a pool of 54 college students, 17 seronegative subjects and 14 subjects with intermediate levels of antibodies against mumps were vaccinated with a monovalent mumps vaccine and CMI was assessed using an interferon-γ release assay. RESULTS: CMI positivity in subjects classified by pre-existing antibody levels, which gave groups with titers of <2...
April 22, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28431124/childhood-vaccinations-and-risk-of-acute-lymphoblastic-leukaemia-in-children
#2
Signe Holst Søegaard, Klaus Rostgaard, Kjeld Schmiegelow, Mads Kamper-Jørgensen, Marie Hargreave, Henrik Hjalgrim, Anders Hviid
Background: It has been proposed that childhood vaccinations protect against acute lymphoblastic leukaemia (ALL) in children by modulation of future responses to common infections in childhood. However, the available studies provide inconsistent findings, and population-based cohort studies with longitudinal information on vaccinations are lacking. Methods: In a register-based cohort of all children born in Denmark from 1 January 1990 to 31 December 2008, followed up until age 15 years or 31 December 2009 ( n  = 1 225 404), we evaluated exposure to childhood vaccination and risk of childhood ALL, including information on ALL subtypes...
April 19, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28421976/-measles-after-mmr-vaccination
#3
R van Grootveld, L M Klitsie, D C M van der Kaay, A C T M Vossen, A C Dijkmans
BACKGROUND: The Dutch national vaccination program provides vaccination for mumps, measles and rubella (MMR vaccine) for all children. After vaccination with live attenuated viruses, the virus replicates on a limited scale. Replication may lead to mild symptoms occurring 5-14 days after MMR-vaccination, including fever, conjunctivitis and rash. Symptoms are comparable to those of a wildtype measles infection. CASE DESCRIPTION: A 14-month-old boy was admitted to the hospital with an impressive rash 13 days after MMR-vaccination...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28420681/mumps-in-a-27-year-old-man
#4
J Brad Wiggers, Tiffany Chan, Wayne L Gold, Derek R MacFadden
No abstract text is available yet for this article.
April 18, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28415019/recovery-of-infective-virus-particles-in-ion-exchange-and-hydrophobic-interaction-monolith-chromatography-is-influenced-by-particle-charge-and-total-to-infective-particle-ratio
#5
Dora Sviben, Dubravko Forcic, Jelena Ivancic-Jelecki, Beata Halassy, Marija Brgles
Viral particles are used in medical applications as vaccines or gene therapy vectors. In order to obtain product of high purity, potency and safety for medical use purification of virus particles is a prerequisite, and chromatography is gaining increased attention to meet this aim. Here, we report on the use of ion-exchange and hydrophobic interaction chromatography on monolithic columns for purification of mumps virus (MuV) and measles virus (MeV). Efficiency of the process was monitored by quantification of infective virus particles (by 50% cell culture infective dose assay) and total virus particles, and monitoring of their size (by Nanoparticle Tracking Analysis)...
April 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28414002/global-importation-and-population-risk-factors-for-measles-in-new-zealand-a-case-study-for-highly-immunized-populations
#6
D T S Hayman, J C Marshall, N P French, T E Carpenter, M G Roberts, T Kiedrzynski
As endemic measles is eliminated through immunization, countries must determine the risk factors for the importation of measles into highly immunized populations to target control measures. Despite eliminating endemic measles, New Zealand suffers from outbreaks after introductions from abroad, enabling us to use it as a model for measles introduction risk. We used a generalized linear model to analyze risk factors for 1137 measles cases from 2007 to June 2014, provide estimates of national immunity levels, and model measles importation risk...
April 17, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28406886/notes-from-the-field-complications-of-mumps-during-a-university-outbreak-among-students-who-had-received-2-doses-of-measles-mumps-rubella-vaccine-iowa-july-2015-may-2016
#7
Matthew Donahue, Allison Schneider, Ugochi Ukegbu, Minesh Shah, Jacob Riley, Andrew Weigel, Lisa James, Kathleen Wittich, Patricia Quinlisk, Cristina Cardemil
No abstract text is available yet for this article.
April 14, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28406739/survey-of-contraindications-in-children-routine-vaccination-in-hangzhou-china
#8
Shijun Liu, Jun Wang, Yan Liu, Yuyang Xu, Xinren Che, Wenwen Gu, Jian Du, Xiaoping Zhang, Erping Xu
Objective To describe the epidemiological characteristics of contraindications in children routine vaccination, to evaluate vaccination doctors' ability to determine contraindications. Method Using cross-section study, 34 urban and 15 suburb units were selected from 206 Community Health Center (CHC) in Hangzhou, China. Subjects were all children coming to CHCs for routine vaccination. All situations considered to be unsuitable for vaccination were recorded as contraindications. 3 experts were employed to classify these abnormal records as true or false contraindications...
April 13, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28404679/evaluation-of-taqman-array-card-tac-for-the-detection-of-central-nervous-system-infections-in-kenya
#9
Clayton O Onyango, Vladimir Loparev, Shirley Lidechi, Vinod Bhullar, D Scott Schmid, Kay Radford, Michael K Lo, Paul Rota, Barbara W Johnson, Jorge Munoz, Martina Oneko, Deron Burton, Carolyn M Black, John Neatherlin, Joel M Montgomery, Barry Fields
Infections of the central nervous system (CNS) are often acute with significant morbidity and mortality. Routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-Saharan Africa. We developed a TaqMan Array Card (TAC) that detects multiple pathogens simultaneously from cerebrospinal fluid (CSF). The 21-pathogen TAC assays include two parasites (Balamuthia mandrillaris and Acanthamoeba), six bacterial pathogens (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, and Bartonella) and 13 viruses (parechovirus, dengue, nipah, varicella zoster, mumps, measles, lyssa, herpes simplex virus 1 and 2, Epstein Barr virus, enterovirus, cytomegalovirus and chikungunya)...
April 12, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28398711/major-birth-defects-after-vaccination-reported-to-the-vaccine-adverse-event-reporting-system-vaers-1990-to-2014
#10
Pedro L Moro, Janet Cragan, Paige Lewis, Lakshmi Sukumaran
BACKGROUND: Major birth defects are important infant outcomes that have not been well studied in the postmarketing surveillance of vaccines given to pregnant women. We assessed the presence of major birth defects following vaccination in the Vaccine Adverse Event Reporting System (VAERS), a national spontaneous reporting system used to monitor the safety of vaccines in the United States. METHODS: We searched VAERS for reports of major birth defects during January 1, 1990, through December 31, 2014...
April 11, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28397866/epidemiological-characteristics-and-spatial-temporal-clusters-of-mumps-in-shandong-province-china-2005-2014
#11
Runzi Li, Shenghui Cheng, Cheng Luo, Shannon Rutherford, Jin Cao, Qinqin Xu, Xiaodong Liu, Yanxun Liu, Fuzhong Xue, Qing Xu, Xiujun Li
Mumps presents a serious threat to public health in China. We conducted a descriptive analysis to identify the epidemiological characteristics of mumps in Shandong Province. Spatial autocorrelation and space-time scan analyses were utilized to detect spatial-temporal clusters. From 2005 to 2014, 115745 mumps cases were reported in Shandong, with an average male-to-female ratio of 1.94. Mumps occurred mostly in spring (32.17% of all reported cases) and in children aged 5 to 9 (40.79% of all reported cases). The Moran's I test was significant and local indicators of spatial autocorrelation (LISA) analysis revealed significant spatial clusters with high incidence...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28397057/clinical-application-analysis-of-andrographolide-total-ester-sulfonate-injection-a-traditional-chinese-medicine-licensed-in-china
#12
Ying Zhao, Pu Huang, Zhe Chen, Si-Wei Zheng, Jin-Yang Yu, Chen Shi
Andrographolide total ester sulfonate (ATES) injection is one of the products of traditional Chinese medicine (TCM) currently used against viral infection in China. ATES injection was approved for manufacturing and marketing in January 2002. It is indicated for acute respiratory infections, tonsillitis, chronic obstructive pulmonary disease, influenza, foot and mouth disease, bronchiolitis, herpangina, mumps, infectious mononucleosis and psychosis. However, its usage also carries risk. We investigated the use of ATES at the Wuhan Union Hospital from January 2014 to December 2014 and evaluated its real-world clinical application using the hospital centralized monitoring method...
April 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28395468/-antibody-persistence-following-on-different-vaccination-strategies-of-domestic-measles-mumps-and-rubella-combined-attenuated-live-vaccine-a-3-year-follow-up-study
#13
H Q He, Q Li, R Yan, Y Zhou, X W Tang, X Deng, S Y Xie, Z P Chen
Objective: To assess the 3-year antibody persistence after vaccination of domestic measles, mumps and rubella combined attenuated live vaccine (MMR) with different program. Methods: Children from three different vaccination strategies (Group 8 m MR: 8 months and 18 months vaccinated with measles-rubella combined attenuated live vaccine and domestic MMR,respectively; Group 8 m MMR: 8 months and 18 months both vaccinated with domestic MMR; Group 12 m MMR: 12 months and 22 months both vaccinated with domestic MMR ) were followed up in Zhejiang province in July 2015...
April 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28390326/active-safety-monitoring-of-measles-mumps-rubella-vaccine-in-the-national-immunisation-programme-of-sri-lanka
#14
K Sanchayan, R Fernandopulle, A Amarasinghe, S N Thiyahiny, S Sri Ranganathan
Objectives: This study was designed to report incidence and characteristics of selected adverse events following immunisation which have consistent causal association (AEFIc) with Measles-Mumps-Rubella (MMR) vaccination given at the age of one year in the National Immunisation Programme of Sri Lanka. Methods: The data presented here were obtained from a cohort event monitoring study. It was carried out in the Jaffna Regional Directorate of Health Services area from November 2012 to December 2014...
March 31, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28379785/voluntarily-reported-immunization-registry-data-reliability-and-feasibility-to-predict-immunization-rates-san-diego-california-2013
#15
Zachary J Madewell, Robert B Wester, Wendy W Wang, Tyler C Smith, K Michael Peddecord, Jessica Morris, Heidi DeGuzman, Mark H Sawyer, Eric C McDonald
OBJECTIVES: Accurate data on immunization coverage levels are essential to public health program planning. Reliability of coverage estimates derived from immunization information systems (IISs) in states where immunization reporting by medical providers is not mandated by the state may be compromised by low rates of participation. To overcome this problem, data on coverage rates are often acquired through random-digit-dial telephone surveys, which require substantial time and resources...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28368471/effectiveness-of-early-measles-mumps-and-rubella-vaccination-among-6-14-month-old-infants-during-an-epidemic-in-the-netherlands-an-observational-cohort-study
#16
Tom Woudenberg, Nicoline A T van der Maas, Mirjam J Knol, Hester de Melker, Rob S van Binnendijk, Susan J M Hahné
Background.: Routinely, the first measles, mumps, and rubella (MMR) vaccine dose is given at 14 months of age in the Netherlands. However, during a measles epidemic in 2013-2014, MMR vaccination was also offered to 6-14-month-olds in municipalities with <90% MMR vaccination coverage. We studied the effectiveness of the early MMR vaccination schedule. Methods.: Parents of all infants targeted for early MMR vaccination were asked to participate. When parent(s) suspected measles, their infant's saliva was tested for measles-specific antibodies...
March 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28366032/etiology-of-single-sided-deafness-and-asymmetrical-hearing-loss
#17
Shin-Ichi Usami, Ryosuke Kitoh, Hideaki Moteki, Shin-Ya Nishio, Tomohiro Kitano, Masafumi Kobayashi, Jun Shinagawa, Yoh Yokota, Kenjiro Sugiyama, Kizuki Watanabe
CONCLUSIONS: The present study revealed that various etiologies are involved in single-sided deafness (SSD), and that the cause of SSD and asymmetrical hearing loss (AHL) differed greatly between congenital/early-onset cases and adult cases. Clarification of the etiology is the first step toward providing appropriate intervention. OBJECTIVES: The study aimed to clarify the etiology of SSD and AHL patients. METHODS: The etiology of a total of 527 SSD or AHL patients who visited Shinshu University Hospital between 2006 and 2016 were analyzed by imaging as well as serological tests for mumps virus, and CMV DNA testing...
April 1, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28363926/measles-outbreaks-in-the-uk-is-it-when-and-where-rather-than-if-a-database-cohort-study-of-childhood-population-susceptibility-in-liverpool-uk
#18
Alex Keenan, Sam Ghebrehewet, Roberto Vivancos, Dan Seddon, Peter MacPherson, Daniel Hungerford
OBJECTIVES: There was a large outbreak of measles in Liverpool, UK, in 2012-2013, despite measles, mumps and rubella (MMR) immunisation uptake rates that were higher than the national average. We estimated measles susceptibility of a cohort of children born in Liverpool between 1995 and 2012 to understand whether there was a change in susceptibility before and after the outbreak and to inform vaccination strategy. DESIGN: Retrospective cohort study. SETTING: The city of Liverpool, North West UK...
March 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28362871/establishing-a-small-animal-model-for-evaluating-protective-immunity-against-mumps-virus
#19
Adrian Pickar, Pei Xu, Andrew Elson, James Zengel, Christian Sauder, Steve Rubin, Biao He
Although mumps vaccines have been used for several decades, protective immune correlates have not been defined. Recently, mumps outbreaks have occurred in vaccinated populations. To better understand the causes of the outbreaks and to develop means to control outbreaks in mumps vaccine immunized populations, defining protective immune correlates will be critical. Unfortunately, no small animal model for assessing mumps immunity exists. In this study, we evaluated use of type I interferon (IFN) alpha/beta receptor knockout mice (IFN-α/βR-/-) for such a model...
2017: PloS One
https://www.readbyqxmd.com/read/28362563/immunogenicity-and-safety-of-a-novel-mmr-vaccine-live-freeze-dried-containing-the-edmonston-zagreb-measles-strain-the-hoshino-mumps-strain-and-the-ra-27-3-rubella-strain-results-of-a-randomized-comparative-active-controlled-phase-iii-clinical-trial
#20
Ashwani Sood, Monjori Mitra, Himanshu Arvind Joshi, Uma Siddhartha Nayak, Prashanth Siddaiah, T Ramesh Babu, Samarendra Mahapatro, Jayesh Sanmukhani, Gaurav Gupta, Ravindra Mittal, Reinhard Glueck
This phase III clinical trial was conducted to evaluate the immunogenicity and safety of the single-dose and multi-dose formulations of a novel MMR vaccine (live, freeze-dried) developed by M/s Cadila Healthcare Limited, India (Cadila MMR vaccine), containing the Hoshino mumps strain, compared to that of an existing MMR vaccine (live, freeze-dried) developed by M/s Serum Institute of India Limited, India (Serum MMR vaccine). These two vaccines have similar measles and rubella strains, but different mumps strains (Hoshino in Cadila MMR vaccine, and L-Zagreb in Serum MMR vaccine)...
March 31, 2017: Human Vaccines & Immunotherapeutics
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