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https://www.readbyqxmd.com/read/28633890/universal-measles-mumps-rubella-vaccination-to-new-recruits-and-the-incidence-of-mumps-in-the-military
#1
Jong Youn Moon, Jaehun Jung, Kyungmin Huh
In response to the resurgence of mumps, the Korean Armed Forces started the measles-mumps-rubella (MMR) vaccination to all new recruits regardless of prior vaccination history. We evaluated the effectiveness of the vaccination by comparing the incidence between the military and civilian populations before and after implementation of the new policy. The standardized incidence ratio of mumps in the military was 7.06 in the prevaccine period, which declined to 0.96 in the postvaccine period. Vaccine effectiveness was estimated at 86...
June 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28633302/mumps-clinical-diagnostic-uncertainty
#2
Fabio Magurano, Melissa Baggieri, Antonella Marchi, Paola Bucci, Giovanni Rezza, Loredana Nicoletti
During recent years, various mumps outbreaks have occurred among populations vaccinated for mumps worldwide. In Italy, improving routine coverage with two doses of measles, mumps and rubella (MMR) vaccine is one of the key strategies to eliminate measles and rubella. To monitor the effect of the vaccination programme on the population, the surveillance of these vaccine-preventable diseases has been implemented. This provided the opportunity to evaluate the accuracy of the clinical diagnosis of those diseases, including mumps...
June 12, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28623030/immunogenicity-of-mumps-virus-vaccine-candidates-matching-circulating-genotypes-in-the-united-states-and-china
#3
James Zengel, Shannon I Phan, Adrian Pickar, Pei Xu, Biao He
Mumps virus (MuV) causes acute infection in humans with characteristic swelling of the parotid gland. While vaccination has greatly reduced the incidence of MuV infection, there have been multiple large outbreaks of mumps virus (MuV) in highly vaccinated populations. The most common vaccine strain, Jeryl Lynn, belongs to genotype A, which is no longer a circulating genotype. We have developed two vaccine candidates that match the circulating genotypes in the United States (genotype G) and China (genotype F)...
June 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28617262/mmr-vaccine-in-the-postpartum-does-not-expose-seronegative-women-to-untoward-effects
#4
Enrico Finale, Giuliana Leonardi, Gaetano Auletta, Roberta Amadori, Chiara Saglietti, Leonardo Pagani, Andrea Guala
BACKGROUND: The aim of this study was to assess whether rubella vaccination immediately after delivery could expose seronegative women to specific untoward effects. METHODS: 163 rubella-seronegative women received Measles-Mumps-Rubella (MMR) vaccine in the immediate postpartum period; they were evaluated at one month and at three months thereafter through telephone interviews. As controls, we matched 163 rubella-seropositive women, who might experience similar symptoms for any reason in the same timeframe...
April 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28606078/how-to-select-a-proper-early-warning-threshold-to-detect-infectious-disease-outbreaks-based-on-the-china-infectious-disease-automated-alert-and-response-system-cidars
#5
Ruiping Wang, Yonggen Jiang, Engelgau Michael, Genming Zhao
BACKGROUND: China Centre for Diseases Control and Prevention (CDC) developed the China Infectious Disease Automated Alert and Response System (CIDARS) in 2005. The CIDARS was used to strengthen infectious disease surveillance and aid in the early warning of outbreak. The CIDARS has been integrated into the routine outbreak monitoring efforts of the CDC at all levels in China. Early warning threshold is crucial for outbreak detection in the CIDARS, but CDCs at all level are currently using thresholds recommended by the China CDC, and these recommended thresholds have recognized limitations...
June 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28604255/the-effectiveness-of-measles-mumps-rubella-mmr-vaccination-in-the-prevention-of-pediatric-hospitalizations-for-targeted-and-untargeted-infections-a-retrospective-cohort-study
#6
Giuseppe La Torre, Rosella Saulle, Brigid Unim, Angela Meggiolaro, Angelo Barbato, Alice Mannocci, Antonietta Spadea
OBJECTIVES: To evaluate the effectiveness of the measles-mumps-rubella (MMR) vaccine in reducing hospitalizations for infectious disease, targeted and not targeted, as well as from respiratory diseases in children in Rome. METHODS: . The cohort was recomposed through record linkage of two archives (vaccination register and hospital discharge records. RESULTS: The analysis included 11,004 children. 20.9% did not receive the MMR vaccination, 49% and 30...
June 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28602605/vaccination-in-newly-arrived-immigrants-to-the-european-union
#7
Roman Prymula, Jana Shaw, Roman Chlibek, Ingrid Urbancikova, Karolina Prymulova
The challenge of assimilating millions of immigrants in the European region each year presents significant socioeconomic issues. Among them is the threat of vaccine preventable diseases (VPDs) disease transmission within immigrant groups and the broader population given the permeability of nation state borders. A total of 3.8 million people immigrated to the European Union (EU) in 2014, among those were 1.6 million non-EU nationals. While vaccines have markedly reduced the transmission of disease, clusters of under-vaccinated individuals potentiate the rapid transmission of once-eradicated or controlled diseases...
June 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28601688/structure-and-organization-of-paramyxovirus-particles
#8
REVIEW
Robert M Cox, Richard K Plemper
The paramyxovirus family comprises major human and animal pathogens such as measles virus (MeV), mumps virus (MuV), the parainfluenzaviruses, Newcastle disease virus (NDV), and the highly pathogenic zoonotic hendra (HeV) and nipah (NiV) viruses. Paramyxovirus particles are pleomorphic, with a lipid envelope, nonsegmented RNA genomes of negative polarity, and densely packed glycoproteins on the virion surface. A number of crystal structures of different paramyxovirus proteins and protein fragments were solved, but the available information concerning overall virion organization remains limited...
June 8, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28599044/mumps
#9
Mark W Burnett
No abstract text is available yet for this article.
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28597093/-pediatric-salivary-gland-tumors-and-tumor-like-lesions
#10
REVIEW
A Agaimy, H Iro, J Zenk
Salivary gland tumors and tumor-like lesions in the pediatric population are uncommon. They comprise a heterogeneous group of infectious/inflammatory and neoplastic conditions. Pediatric salivary neoplasms include benign tumors of mesenchymal or epithelial origin as well as malignancies of epithelial (carcinomas), mesenchymal (sarcoma) or hematolymphoid (lymphoma) derivation. Infectious/inflammatory conditions and hematolymphoid malignancies may represent either genuine parenchymal pathology or conditions involving intraglandular lymph nodes of the parotid glands (intraglandular lymphadenopathy and intraglandular nodal lymphomas)...
June 9, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28595358/reduced-antibody-response-to-infant-measles-vaccination-effects-based-on-type-and-timing-of-the-first-vaccine-dose-persist-after-the-second-dose
#11
Sara Carazo Perez, Gaston De Serres, Alexandre Bureau, Danuta M Skowronski
Background: The effect of age at first dose on the immunogenicity of a two-dose pediatric schedule of Measles-Mumps-Rubella (MMR) or MMR-Varicella (MMRV) vaccines was assessed in children born to mostly vaccinated mothers. Methods: Immunogenicity data among children given their first measles vaccine dose between 11 and 22 months of age were pooled from five randomized controlled trials conducted in Europe and the United States between 2004 and 2010. Measles antibody titers were measured by ELISA before/after each dose: geometric mean concentrations (GMCs) and the proportion sero-negative (GMC<150mIU/ml) were derived by age at first dose...
June 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28594599/genetic-variants-in-the-il-4-il-13-pathway-influence-measles-vaccine-responses-and-vaccine-failure-in-children-from-mozambique
#12
Holly D Clifford, Catherine M Hayden, Siew-Kim Khoo, Denise Naniche, Inacio M Mandomando, Guicheng Zhang, Peter Richmond, Peter N Le Souëf
Despite effective measles vaccines, measles still causes severe morbidity and mortality worldwide, particularly in developing countries. The Th2 pathway involving interleukin (IL)-4 and IL-13 cytokines, and their receptor IL-4Rα, play important roles in the Th1/Th2 balance and antibody production. A Th2 skewing of the cytokine milieu may affect vaccine responses. We investigated IL-4, IL-13, and IL-4Rα polymorphisms and their impact on measles IgG responses and measles vaccine failure, in two separate cohorts: 12-month-old Australian children immunized with measles-mumps-rubella vaccine (n = 137) and a case/control cohort of children aged 6 months-14 years from Mozambique, Africa (n = 89), some of whom were vaccinated, but still contracted measles (vaccine failure)...
June 8, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28583925/bilateral-isolated-submandibular-gland-mumps
#13
Linnea Cheung, Arthur Harry Henderson, Graham Banfield, Andrew Carswell
Isolated submandibular swellings pose a diagnostic challenge to the practising otolaryngologist. We report an unusual case of mumps isolated to bilateral submandibular glands. We discuss the case and the literature surrounding this condition and remind clinicians that mumps should be considered as a diagnosis in the presence of submandibular gland swelling in the absence of typical parotid swelling associated with mumps. Early consideration of this differential diagnosis, serological testing and a multidisciplinary approach may help to clinch the diagnosis earlier and prevent spread of the virus...
June 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28561947/modeling-the-transmission-of-measles-and-rubella-to-support-global-management-policy-analyses-and-eradication-investment-cases
#14
Kimberly M Thompson, Nima D Badizadegan
Policy makers responsible for managing measles and rubella immunization programs currently use a wide range of different vaccines formulations and immunization schedules. With endemic measles and rubella transmission interrupted in the region of the Americas, all five other regions of the World Health Organization (WHO) targeting the elimination of measles transmission by 2020, and increasing adoption of rubella vaccine globally, integrated dynamic disease, risk, decision, and economic models can help national, regional, and global health leaders manage measles and rubella population immunity...
May 31, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28558983/enhancing-global-vaccine-pharmacovigilance-proof-of-concept-study-on-aseptic-meningitis-and-immune-thrombocytopenic-purpura-following-measles-mumps-containing-vaccination
#15
Silvia Perez-Vilar, Daniel Weibel, Miriam Sturkenboom, Steven Black, Christine Maure, Jose Luis Castro, Pamela Bravo-Alcántara, Caitlin N Dodd, Silvana A Romio, Maria de Ridder, Swabra Nakato, Helvert Felipe Molina-León, Varalakshmi Elango, Patrick L F Zuber
New vaccines designed to prevent diseases endemic in low and middle-income countries (LMICs) are now being introduced without prior record of utilization in countries with robust pharmacovigilance systems. To address this deficit, our objective was to demonstrate feasibility of an international hospital-based network for the assessment of potential epidemiological associations between serious and rare adverse events and vaccines in any setting. This was done through a proof-of-concept evaluation of the risk of immune thrombocytopenic purpura (ITP) and aseptic meningitis (AM) following administration of the first dose of measles-mumps-containing vaccines using the self-controlled risk interval method in the primary analysis...
May 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28543433/mumps-outbreak-in-a-tribal-population-from-the-union-territory-of-dadra-and-nagar-haveli-india
#16
Siddharth M Tilavat, Sunil R Vaidya, Venkat S Hamde
A cluster of parotitis cases (n=13) were observed in a tribal population of Vansda village from the Union Territory of Dadra and Nagar Haveli, India between 20(th) and 22(nd) week of 2016. Primary information was received by the local Infectious Disease Surveillance Program team, and subsequently field investigations were carried out in the affected area. Active surveillance was conducted till twice the incubation period from onset of the last surveyed case. For the laboratory investigations, 19 serum samples were collected from 11-suspected cases and their close contacts (n=8)...
May 20, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28542125/notes-from-the-field-measles-outbreak-at-a-united-states-immigration-and-customs-enforcement-facility-arizona-may-june-2016
#17
Heather Venkat, Ahmed M Kassem, Chia-Ping Su, Clancey Hill, Evan Timme, Graham Briggs, Kenneth Komatsu, Susan Robinson, Rebecca Sunenshine, Manisha Patel, Diana Elson, Paul Gastañaduy, Shane Brady
HASH(0x4398d00)
May 26, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28505632/missed-opportunities-for-measles-mumps-rubella-vaccination-among-departing-u-s-adult-travelers-receiving-pretravel-health-consultations
#18
Emily P Hyle, Sowmya R Rao, Emily S Jentes, Amy Parker Fiebelkorn, Stefan H F Hagmann, Allison Taylor Walker, Rochelle P Walensky, Edward T Ryan, Regina C LaRocque
Background: Measles outbreaks continue to occur in the United States and are mostly due to infections in returning travelers. Objective: To describe how providers assessed the measles immunity status of departing U.S. adult travelers seeking pretravel consultation and to assess reasons given for nonvaccination among those considered eligible to receive the measles, mumps, rubella (MMR) vaccine. Design: Observational study in U.S. pretravel clinics...
May 16, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28501474/a-case-of-mumps-related-acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion
#19
Kyoko Hazama, Takashi Shiihara, Hiroyuki Tsukagoshi, Shunji Hasegawa, Yuri Dowa, Mio Watanabe
BACKGROUND: Mumps is a common childhood viral disease characterized by fever and swelling of the parotid gland. The prognosis is generally good, although some complications, such as encephalitis (0.1%), exist. Acute encephalopathy with biphasic seizures and late reduced diffusion is the most common type of acute encephalopathy. However, this type of encephalopathy has not been reported in association with mumps infection. PATIENT: A previously healthy 3-year-old Japanese boy had a brief convulsion after fever for 3days, and then had conscious disturbance and parotitis...
May 10, 2017: Brain & Development
https://www.readbyqxmd.com/read/28500809/investigating-mumps-outbreak-in-odisha-india-an-opportunity-to-assess-the-health-system-by-utilizing-the-essential-public-health-services-framework
#20
Sourabh Paul, Preetam B Mahajan, Jyotiranjan Sahoo, Vikas Bhatia, Sonu H Subba
AbstractMumps, a highly contagious, viral disease continues to spread in India, despite the availability of an effective vaccine. On November 24, 2014, we came across a suspected case of mumps in a 6-year-old boy in a village of Bhusandapur sector in Odisha. We initiated an outbreak investigation using standard techniques outlined by the Centers for Disease Control and Prevention, Atlanta, GA. This uncovered a silent epidemic of 94 case patients (10% of the population) over a period of 16 weeks between August and December 2014, in a single village, which had gone completely unnoticed by the existing health-care system...
May 2017: American Journal of Tropical Medicine and Hygiene
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