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https://www.readbyqxmd.com/read/29774869/genetic-epidemiology-and-risk-factors-for-brain-tumors
#1
Xuejun Li, Hang Cao, Yanhong Liu
This report summarized current knowledge and findings relevant to environmental and genetic risk factors in brain tumors, with a particular focus on glioma. To date, the established risk factors for brain tumors are family history and ionizing radiation exposure; whereas there is an inverse association between tumors and other factors such as history of allergies, atopic conditions, chickenpox, and varicella zoster virus infection. To identify inherited genetic variants impacting susceptibility of brain tumors, large scale familial linkage-scan pedigree analysis, population-based candidate genes, and genome-wide association study were performed...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29771626/effectiveness-and-impact-of-a-single-dose-vaccine-against-chickenpox-in-the-community-of-madrid-between-2001-and-2015
#2
Pello Latasa, Angel Gil de Miguel, Maria Dolores Barranco Ordoñez, Inmaculada Rodero Garduño, Juan Carlos Sanz Moreno, María Ordobás Gavín, María Esteban-Vasallo, Macarena Garrido-Estepa, Luis García-Comas
BACKGROUND: Chickenpox is a contagious airborne disease. Immunization by varicella vaccine is an effective preventive measure. The objective of this study is to evaluate the impact and effectiveness of a single-dose vaccination against chickenpox at 15 months of age. METHODS: Observational study based on data from the Epidemiological Surveillance System of the Autonomous Community of Madrid from 2001 to 2015. The years were grouped into 4 periods according to epidemic cycles and vaccination schedule: 2001-06, 2007-10, 2011-13 and 2014-15...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29766472/epidemiology-management-and-outcome-of-varicella-in-pregnancy-a-20-year-experience-at-the-tuscany-reference-centre-for-infectious-diseases-in-pregnancy
#3
Michele Trotta, Beatrice Borchi, Alessandra Niccolai, Elisabetta Venturini, Susanna Giaché, Gaetana Sterrantino, Maria Grazia Colao, Gian Maria Rossolini, Alessandro Bartoloni, Lorenzo Zammarchi
Data from 215 pregnant women exposed to varicella and 276 with varicella observed at the Tuscany Reference Center for Infectious Diseases in Pregnancy, Florence, Italy, in the period 1997-2016 were retrospectively collected. The risk of developing varicella was lower in exposed women who received varicella zoster immunoglobulin compared with those who did not receive it [42% (21 of 50) vs 72% (13 of 18); p = 0.0263]. Typical congenital varicella syndrome was observed in 1.56% of fetuses/neonates born from pregnant women with varicella...
May 15, 2018: Infection
https://www.readbyqxmd.com/read/29763349/molar-incisor-hypomineralization-positive-correlation-with-atopic-dermatitis-and-food-allergies
#4
Miguel Hernandez, Juan Boj, Enric Espasa, Paloma Planells, Benjamin Peretz
AIM: Molar-incisor hypomineralization is a disturbance in dental development that involves first permanent molars as well as permanent incisors with a prevalence that ranges from 2.5% to 40%. The objective of this study was to investigate the etiology of molar-incisor hypomineralization among school children from two randomly selected towns in the province of Barcelona, Spain. STUDY DESIGN: A cross-sectional study was conducted with 705 children ranging in age from six years-old to 14 years and 11 months-old...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29758495/a-rapid-magnetic-particle-based-enzyme-immunoassay-for-human-cytomegalovirus-glycoprotein-b-quantification
#5
F Pires, M Julia Arcos-Martinez, A Cristina Dias-Cabral, Juan C Vidal, Juan R Castillo
Human cytomegalovirus (HCMV) is a herpes virus that can cause severe infections. Still, the available methods for its diagnostic have the main disadvantage of requiring long time to be performed. In this work, a simple magnetic particle-based enzyme immunoassay (mpEIA) for the quantification of glycoprotein B of Human cytomegalovirus (gB-HCMV) in urine samples is proposed. The immunosensor scheme is based on the analyte protein gB-HCMV sandwiched between a primary monoclonal antibody, (MBs-PrG-mAb1), and a secondary anti-gB-HCMV antibody labelled with Horseradish peroxidase (Ab2-HRP) to allow spectrophotometric detection...
April 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29754137/unusual-cause-of-brachial-palsy-with-diaphragmatic-palsy
#6
Vishal Gupta, Aakash Pandita, Astha Panghal, Neha Hassan
We report a preterm neonate born with respiratory distress. The neonate was found to have diaphragmatic palsy and brachial palsy. The neonate was born by caesarean section and there was no history of birth trauma. On examination, there was bilateral congenital talipes equinovarus and a scar was present on the forearm. The mother had a history of chickenpox during the 16 weeks of pregnancy for which no treatment was sought. On investigation, PCR for varicella was found to be positive in the neonate.
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29754069/high-resolution-vessel-wall-mri-and-vasculopathy-related-to-herpes-zoster-ophthalmicus
#7
Jae W Song, Sam Ojeda, Javier M Romero
Varicella zoster virus is a common viral infection with over 50% of patients over the age of 80 years infected with the virus. Following reactivation, some patients succumb to complications of VZV reactivation with neurologic and optic pathway pathology such as VZV vasculopathy resulting in transient ischemic attacks, strokes, aneurysms, as well as optic neuritis. We show that high resolution vessel wall magnetic resonance imaging can aid in the diagnosis of this condition with circumferential wall thickening and enhancement of the infected vessels...
May 3, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29750672/infusion-of-cytotoxic-t-lymphocytes-for-the-treatment-of-viral-infections-in-hematopoetic-stem-cell-transplant-patients
#8
Katherine A Baugh, Ifigeneia Tzannou, Ann M Leen
PURPOSE OF REVIEW: Allogeneic hematopoietic stem cell transplantation has proven curative for a range of malignant and nonmalignant disorders. However, the clinical success of this therapy is marred by the morbidity associated with viral infections, which are frequent (cytomegalovirus 15.6-28%, adenovirus 3-21%, BK virus 18.5-20.7%) post-transplant. These infections occur as a consequence of transplant conditioning regimens designed to eliminate not only malignant cells but also host immune cells that might interfere with stem cell engraftment...
May 9, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29747736/infections-in-pregnancy-and-the-role-of-vaccines
#9
REVIEW
Kimberly B Fortner, Claudia Nieuwoudt, Callie F Reeder, Geeta K Swamy
Pregnant women are at risk for infection and may have significant morbidity or mortality. Influenza, pertussis, zika, and cytomegalovirus produce mild or asymptomatic illness in the mother, but have profound implications for her fetus. Maternal immunization can prevent or mitigate infections in pregnant women and their infants. The Advisory Committee of Immunization Practices recommends 2 vaccines during pregnancy: inactivated influenza, and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis during pregnancy...
June 2018: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/29743372/-breadth-and-functionality-of-varicella-zoster-virus-glycoprotein-specific-antibodies-identified-after-zostavax-vaccination-in-humans
#10
Nicole L Sullivan, Morgan A Reuter-Monslow, Janet Sei, Eberhard Durr, Carl W Davis, Cathy Chang, Megan McCausland, Andreas Wieland, David Krah, Nadine Rouphael, Aneesh K Mehta, Mark J Mulligan, Bali Pulendran, Rafi Ahmed, Kalpit A Vora
Herpes zoster (HZ/shingles) is the clinical manifestation of varicella zoster virus (VZV) reactivation. HZ typically develops as people age due to decreased cell-mediated immunity. However, the importance of antibodies for immunity against HZ prevention remains to be understood. The goal of this study was to examine the breadth and functionality of VZV-specific antibodies after vaccination with a live attenuated HZ vaccine (Zostavax). Direct enumeration of VZV-specific antibody secreting cells (ASC) via ELISPOT showed that Zostavax can induce both IgG and IgA ASCs seven days after vaccination, but not IgM ASCs...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29743174/variation-in-practice-remains-in-the-uk-management-of-varicella-postexposure-prophylaxis-in-children-with-cancer
#11
Katharine Jarrold, Jessica Bate
No abstract text is available yet for this article.
May 9, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29738266/early-treatment-was-life-saving-in-varicella-pneumonia-of-an-immunocompetent-adult
#12
Neslihan Çelik, Onur Çelik, Onur Ünal
Chickenpox, an infection of childhood with vesicular skin rash, is caused by varicella-zoster virus (VZV). Although the infection is rare in adults, it can cause serious complications Varicella pneumonia is the most encountered complication. In this report, a VZV pneumonia case in a previously healthy adult is presented. The patient was treated with early intravenous acyclovir and both clinical and radiographic recovery has been observed.
May 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29733991/varicella-zoster-virus-infection-and-osteomyelitis-of-the-skull-a-case-report
#13
Taylor Sommer, Michael Karsy, Meghan J Driscoll, Randy L Jensen
BACKGROUND: Varicella zoster virus (VZV) is a common herpesvirus infection that can result in acute varicella/chickenpox as well as delayed activation in herpes zoster/shingles. Ramsay-Hunt syndrome is a rare presentation of VZV reactivation, involving 1% of cases and resulting in lesion formation along the 7th cranial nerve distribution. We report the first case of a patient who presented with acute calvarial osteomyelitis after VZV reactivation and Propionibacterium acnes suprainfection...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29731177/administrative-data-to-explore-the-role-of-family-history-as-a-risk-factor-for-herpes-zoster
#14
Rafael Harpaz, Rebecca M Dahl
We used administrative data to study the impact of family history on the risk of herpes zoster (HZ). Our HZ cases and our HZ family history were both ascertained on the basis of medically attended diagnoses, without reliance on self-report or recall bias. Family history was associated with HZ risk among both siblings and parents. The strength of the association differed when the index child was latently infected with vaccine-strain vs wild-type varicella zoster virus.
May 3, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29730641/peptalk2-results-of-a-pilot-randomised-controlled-trial-to-compare-vzig-and-aciclovir-as-postexposure-prophylaxis-pep-against-chickenpox-in-children-with-cancer
#15
Jessica Bate, Stephen Baker, Judith Breuer, Julia C Chisholm, Juliet Gray, Sophie Hambleton, Aimee Houlton, Mark Jit, Stephen Lowis, Guy Makin, Catherine O'Sullivan, Soonie R Patel, Robert Phillips, Neil Ransinghe, Mary Elizabeth Ramsay, Roderick Skinner, Keith Wheatley, Paul T Heath
OBJECTIVE: To determine the likely rate of patient randomisation and to facilitate sample size calculation for a full-scale phase III trial of varicella zoster immunoglobulin (VZIG) and aciclovir as postexposure prophylaxis against chickenpox in children with cancer. DESIGN: Multicentre pilot randomised controlled trial of VZIG and oral aciclovir. SETTING: England, UK. PATIENTS: Children under 16 years of age with a diagnosis of cancer: currently or within 6 months of receiving cancer treatment and with negative varicella zoster virus (VZV) serostatus at diagnosis or within the last 3 months...
May 5, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29728610/mutations-in-rna-polymerase-iii-genes-and-defective-dna-sensing-in-adults-with-varicella-zoster-virus-cns-infection
#16
Madalina E Carter-Timofte, Anders F Hansen, Mette Christiansen, Søren R Paludan, Trine H Mogensen
Recently, deficiency in the cytosolic DNA sensor RNA Polymerase III was described in children with severe primary varicella-zoster virus (VZV) infection in the CNS and lungs. In the present study we examined adult patients with VZV CNS infection caused by viral reactivation. By whole exome sequencing we identified mutations in POL III genes in two of eight patients. These mutations were located in the coding regions of the subunits POLR3A and POLR3E. In functional assays, we found impaired expression of antiviral and inflammatory cytokines in response to the POL III agonist Poly(dA:dT) as well as increased viral replication in patient cells compared to controls...
May 1, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29725187/preeruptive-unilateral-cerebellar-ataxia-in-an-immunocompetent-adult-a-rare-case-of-varicella
#17
Chen Fei Ng, Beng Hooi Ong, Hui Jan Tan
No abstract text is available yet for this article.
April 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29720077/australian-paediatric-surveillance-unit-annual-report-2016
#18
Marie Deverell, Amy Phu, Yvonne Zurynski, Elizabeth Elliott
This report summarises the cases reported to the Australian Paediatric Surveillance Unit (APSU) of rare infectious diseases or rare complications of more common infectious diseases in children. During the calendar year 2016, there were approximately 1500 paediatricians reporting to the APSU and the monthly report card return rate was 90%. APSU continued to provide unique national data on the perinatal exposure to HIV, congenital rubella, congenital cytomegalovirus, neonatal and infant herpes simplex virus, and congenital and neonatal varicella...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29720076/paediatric-active-enhanced-disease-surveillance-paeds-annual-report-2015-prospective-hospital-based-surveillance-for-serious-paediatric-conditions
#19
Jocelynne E McRae, Helen E Quinn, Kristine Macartney
Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment for selected serious childhood conditions, particularly vaccine preventable diseases and potential adverse events following immunisation (AEFI). PAEDS data is used to better understand these conditions, inform policy and practice under the National Immunisation Program, and enable rapid public health responses for certain conditions of public health importance...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29720075/surveillance-of-adverse-events-following-immunisation-in-australia-2015
#20
Aditi Dey, Han Wang, Helen Quinn, Jane Cook, Kristine Macartney
This report summarises Australian passive surveillance data for adverse events following immunisation (AEFI) for 2015 reported to the Therapeutic Goods Administration and compares them to long-term trends. There were 2,924 AEFI records for vaccines administered in 2015; an annual AEFI reporting rate of 12.3 per 100,000 population. There was a decline of 7% in the overall AEFI reporting rate in 2015 compared with 2014. This decline in reported adverse events in 2015 compared to the previous year was mainly attributable to fewer reports following the HPV vaccine and replacement of monovalent vaccines (Hib, MenCCV and varicella) with combination vaccines such as Hib-MenC, and MMRV...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
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