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https://www.readbyqxmd.com/read/28806450/evaluation-of-combination-measles-mumps-rubella-varicella-vaccine-introduction-in-australia
#1
Kristine Macartney, Heather F Gidding, Lieu Trinh, Han Wang, Aditi Dey, Brynley Hull, Karen Orr, Jocelynne McRae, Peter Richmond, Michael Gold, Nigel Crawford, Jennifer A Kynaston, Peter McIntyre, Nicholas Wood
Importance: Incorporating combination vaccines, such as the measles-mumps-rubella-varicella (MMRV) vaccine, into immunization schedules should be evaluated from a benefit-risk perspective. Use of MMRV vaccine poses challenges due to a recognized increased risk of febrile seizures (FSs) when used as the first dose in the second year of life. Conversely, completion by age 2 years of measles, mumps, rubella, and varicella immunization may offer improved disease control. Objective: To evaluate the effect on safety and coverage of earlier (age 18 months) scheduling of MMRV vaccine as the second dose of measles-containing vaccine (MCV) in Australia...
August 14, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28803571/a-national-register-based-study-of-paediatric-varicella-hospitalizations-in-denmark-2010-2016
#2
I G Helmuth, A Poulsen, K Mølbak
Varicella, usually a mild disease of childhood, can also cause complications and hospitalization. Universal varicella immunization is implemented in several countries worldwide, but not in Denmark. Taking advantage of unique national registers, we aimed to estimate the incidence of paediatric varicella hospitalizations and assess determinants for hospitalization. For this purpose, we designed a nationwide, retrospective register study of paediatric varicella hospitalizations and applied a case-cohort design and logistic regression analysis comparing hospitalized varicella patients to a sample of the entire paediatric population in Denmark...
August 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28800522/screening-for-infectious-diseases-among-asylum-seekers-newly-arrived-in-germany-in-2015-a%C3%A2-systematic-single-centre-analysis
#3
A Z Kortas, J Polenz, J von Hayek, S Rüdiger, W Rottbauer, U Storr, T Wibmer
OBJECTIVES: During the migrant crisis in 2015, Germany was the largest single recipient of new asylum seekers in Europe. The German asylum law requires a screening examination for certain infectious diseases in asylum seekers upon arrival. The aim of this work was to analyse the rate of certain infectious diseases among asylum seekers screened at a reception centre in Southern Germany. STUDY DESIGN: Retrospective medical record review. METHODS: Medical records of 2602 asylum seekers screened by a local public health authority in Germany in 2015 were systematically analysed...
August 8, 2017: Public Health
https://www.readbyqxmd.com/read/28799957/potential-clue-to-the-pathogenesis-of-varicella-zoster-virus-stromal-keratitis
#4
Amde Selassie Shifera
No abstract text is available yet for this article.
August 9, 2017: Cornea
https://www.readbyqxmd.com/read/28795455/perceptions-of-caregivers-and-providers-regarding-the-potential-introduction-of-the-varicella-vaccine-to-the-childhood-immunisation-schedule-in-new-zealand-a-qualitative-exploratory-study
#5
Nadia A Charania, Donna G Watson, Nikki M Turner
AIM: The varicella vaccine has been proposed to be added to the childhood immunisation schedule in New Zealand as the fourth injectable at the 15-month event. We sought to understand the perceptions of caregivers and health-care providers regarding the potential introduction of routine varicella vaccination. METHODS: A qualitative exploratory study was conducted using semi-structured interviews with caregivers and providers (N = 20) in Auckland. Key themes from the interviews were identified through thematic analysis using a combination of deductive and inductive coding...
August 9, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28790794/varicella-bullosa-in-an-adult
#6
Preema Sinha, Saikat Bhattacharjee, Manas Chatterjee
No abstract text is available yet for this article.
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28783042/inborn-errors-in-rna-polymerase-iii-underlie-severe-varicella-zoster-virus-infections
#7
Benson Ogunjimi, Shen-Ying Zhang, Katrine B Sørensen, Kristian A Skipper, Madalina Carter-Timofte, Gaspard Kerner, Stefanie Luecke, Thaneas Prabakaran, Yujia Cai, Josephina Meester, Esther Bartholomeus, Nikhita Ajit Bolar, Geert Vandeweyer, Charlotte Claes, Yasmine Sillis, Lazaro Lorenzo, Raffaele A Fiorenza, Soraya Boucherit, Charlotte Dielman, Steven Heynderickx, George Elias, Andrea Kurotova, Ann Vander Auwera, Lieve Verstraete, Lieven Lagae, Helene Verhelst, Anna Jansen, Jose Ramet, Arvid Suls, Evelien Smits, Berten Ceulemans, Lut Van Laer, Genevieve Plat Wilson, Jonas Kreth, Capucine Picard, Horst Von Bernuth, Joël Fluss, Stephane Chabrier, Laurent Abel, Geert Mortier, Sebastien Fribourg, Jacob Giehm Mikkelsen, Jean-Laurent Casanova, Søren R Paludan, Trine H Mogensen
Varicella zoster virus (VZV) typically causes chickenpox upon primary infection. In rare cases, VZV can give rise to life-threatening disease in otherwise healthy people, but the immunological basis for this remains unexplained. We report 4 cases of acute severe VZV infection affecting the central nervous system or the lungs in unrelated, otherwise healthy children who are heterozygous for rare missense mutations in POLR3A (one patient), POLR3C (one patient), or both (two patients). POLR3A and POLR3C encode subunits of RNA polymerase III...
August 7, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28781838/acute-pancreatitis-in-immunocompromised-patients-beware-of-varicella-zoster-virus-primo-infection
#8
Adrien Picod, Elise Corre, Eric Maury, Paul Duriez, Nadia Hoyeau, Paul Coppo
Varicella zoster virus (VZV) primo-infection can be severe in the elderly and in immunocompromised patients. Atypical presentations are not uncommon and may mislead the diagnosis and delay adequate treatment. Valacyclovir prophylaxis should be systematically proposed in immunocompromised patients.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28780657/combination-therapy-of-rituximab-and-mycophenolate-mofetil-in-childhood-lupus-nephritis
#9
Julien Hogan, Astrid Godron, Véronique Baudouin, Theresa Kwon, Jérôme Harambat, Georges Deschênes, Olivier Niel
BACKGROUND: In clinical trials, the addition of rituximab (RTX) to the combination therapeutic regimen of mycophenolate mofetil (MMF) and corticosteroids failed to improve outcome in lupus nephritis (LN). However, recent data suggest that RTX may have steroid-sparing beneficial effects with an efficacy similar to that of conventional regimens. We report our experience with RTX in the treatment of children with LN. METHODS: Patients treated with RTX for first occurrence of LN class III to V were enrolled in the study...
August 5, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28774800/highlights-of-the-30th-international-conference-on-antiviral-research
#10
Graciela Andrei, Kara Carter, Zlatko Janeba, Aruna Sampath, Luis M Schang, E Bart Tarbet, R Anthony Vere Hodge, Mike Bray, José A Esté
The 30th International Conference on Antiviral Research (ICAR) was held in Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award lectures, invited keynote addresses and oral presentations during the meeting. The 2017 Gertrude Elion Memorial Lecture Award by Michael Sofia highlighted one of the most important accomplishments in recent drug discovery in antiviral research, the identification of the hepatitis C virus direct-acting antiviral sofosbuvir and new alternatives to combat hepatitis B virus (HBV) infection...
July 31, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28765144/comparing-optical-coherence-tomography-findings-in-different-aetiologies-of-infectious-necrotising-retinitis
#11
Alessandro Invernizzi, Aniruddha Kishandutt Agarwal, Vittoria Ravera, Chiara Mapelli, Agostino Riva, Giovanni Staurenghi, Peter J McCluskey, Francesco Viola
AIMS: To compare optical coherence tomography (OCT) features of active necrotising infectious retinitis (NIR) due to toxoplasmosis or herpesviruses and to determine distinctive OCT signs for these two causes of infectious retinitis. METHODS: OCT scans from eyes with active NIR due to varicella zoster virus (VZV), herpes simplex virus (HSV), cytomegalovirus (CMV), and toxoplasmosis (TOXO) were reviewed. All images were evaluated for the presence of previously described OCT findings in TOXO-NIR and compared with the viral group...
August 1, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28763115/design-synthesis-and-the-biological-evaluation-of-a-new-series-of-acyclic-1-2-3-triazole-nucleosides
#12
Iwona E Głowacka, Graciela Andrei, Dominique Schols, Robert Snoeck, Katarzyna Gawron
A new strategy for the synthesis of N(3) -benzoylated- and N(3) -benzylated N(1) -propargylquinazoline-2,4-diones 30a-d and 31a-d from isatoic anhydride 41 is reported. The alkynes 30a-d and 31a-d were applied in the 1,3-dipolar cycloadditions with azides 27 and 28 to synthesize acyclic 1,2,3-triazole nucleosides. The obtained alkynes and 1,2,3-triazole were evaluated for antiviral activity against a broad range of DNA and RNA viruses. The alkyne 30d showed activity against adenovirus-2 (EC50  = 8.3 μM), while compounds 37a and 37d were also active toward herpes simplex virus-1 wild-type and thymidine kinase deficient (HSV-1 TK(-) ) strains (EC50 values in the range of 4...
August 1, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28762675/major-birth-defects-after-vaccination-reported-to-the-vaccine-adverse-event-reporting-system-vaers-1990-to-2014
#13
Pedro L Moro, Janet Cragan, Paige Lewis, Lakshmi Sukumaran
BACKGROUND: Major birth defects are important infant outcomes that have not been well studied in the postmarketing surveillance of vaccines given to pregnant women. We assessed the presence of major birth defects following vaccination in the Vaccine Adverse Event Reporting System (VAERS), a national spontaneous reporting system used to monitor the safety of vaccines in the United States. METHODS: We searched VAERS for reports of major birth defects during January 1, 1990, through December 31, 2014...
July 17, 2017: Birth defects research
https://www.readbyqxmd.com/read/28758156/varicella-zoster-virus-and-large-vessel-vasculitis-the-absence-of-an-association
#14
Gary W Procop, Charis Eng, Alison Clifford, Alexandra Villa-Forte, Leonard H Calabrese, Eric Roselli, Lars Svensson, Douglas Johnston, Gosta Pettersson, Edward Soltesz, Lisa Lystad, Julian D Perry, Alexander Blandford, Deborah A Wilson, Gary S Hoffman
OBJECTIVE: It is controversial whether microorganisms play a role in the pathogenesis of large and medium vessel vasculitides (eg, giant cell arteritis [GCA], Takayasu arteritis [TAK] and focal idiopathic aortitis [FIA]). Recent studies have reported the presence of Varicella Zoster Virus (VZV) within formalin-fixed, paraffin-embedded temporal arteries and aortas of about three-quarters or more of patients with these conditions, and in a minority of controls. In a prospective study, we sought to confirm these findings using DNA extracted from vessels that were harvested under surgically aseptic conditions and snap frozen...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28757102/new-prodrugs-of-two-pyrimidine-acyclic-nucleoside-phosphonates-synthesis-and-antiviral-activity
#15
Marcela Krečmerová, Martin Dračínský, Robert Snoeck, Jan Balzarini, Karel Pomeisl, Graciela Andrei
New 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine (PMEO-DAPy) and 1-[2-(phosphonomethoxy)ethyl]-5-azacytosine (PME-5-azaC) prodrugs were prepared with a pro-moiety consisting of carbonyloxymethyl esters (POM, POC), alkoxyalkyl esters, amino acid phosphoramidates and/or tyrosine. The activity of the prodrugs was evaluated in vitro against different virus families. None of the synthesized prodrugs demonstrated activity against RNA viruses but some of them proved active against herpesviruses [including herpes simplex virus (HSV), varicella-zoster virus (VZV), and human cytomegalovirus (HCMV)]...
July 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28757060/mmr-and-mmrv-vaccines
#16
Frank Kowalzik, Jörg Faber, Markus Knuf
Measles, mumps, rubella and varicella are viral infections which can implicate seriously long-term sequelae of infected individuals or even the unborn child. Vaccines against the individual diseases have long been available. Global measles vaccination is estimated to have prevented more than 20million deaths during 2000-2015. During the same time period, measles incidence decreased from 146 to 36 cases per million populations. Today vaccinations against measles, mumps, rubella and varicella are now carried out mainly with combination vaccines...
July 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28752294/characterization-and-phylogenetic-analysis-of-varicella-zoster-virus-strains-isolated-from-korean-patients
#17
Min Ho Kim, Jeong Seon Jeon, In Kyo Kim, Ji Seon Park, Hosun Park, Ok Sarah Shin, Chan Hee Lee
Varicella-zoster virus (VZV) is a causative agent of chickenpox in primary infection and shingles after its reactivation from latency. Complete or almost-complete genomic DNA sequences for various VZV strains have been reported. Recently, clinical VZV strains were isolated from Korean patients whose genome was sequenced using high-throughput sequencing technology. In this study, we analyzed single nucleotide polymorphism (SNP) of VZV strains to genetically characterize Korean clinical isolates. Phylogenetic analyses revealed that three Korean strains, YC01, YC02, and YC03, were linked to clade 2...
August 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28751095/a-comprehensive-review-of-immunization-practices-in-solid-organ-transplant-and-hematopoietic-stem-cell-transplant-recipients
#18
REVIEW
Pearlie P Chong, Robin K Avery
BACKGROUND: Vaccine-preventable diseases, especially influenza, varicella, herpes zoster, and invasive pneumococcal infections, continue to lead to significant morbidity and mortality in solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients. METHODS: We highlight guideline recommendations for the use of key vaccines in SOT and HSCT recipients and to review the latest evidence and developments in the field. RESULTS: Physicians should vaccinate individuals with end-stage organ disease, as vaccine seroresponse rates are higher pretransplantation...
July 24, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28750305/progressive-hippocampal-sclerosis-after-viral-encephalitis-potential-role-of-nmda-receptor-antibodies
#19
Stoyan Popkirov, Fatme Seval Ismail, Wenke Grönheit, Monika Kapauer, Jörg Wellmer, Christian G Bien
PURPOSE: Survivors of viral encephalitis can develop refractory epilepsy and hippocampal sclerosis. Both the initial infectious insult and the secondary effects of recurrent seizures have been implicated in chronic disease progression. Recently, post-infectious autoimmunity, involved in acute relapses, has also been proposed as a pathomechanism for chronic disease progression. Our case series suggests a potential role of antibodies against the N-methyl-d-aspartate receptor (NMDAR) in chronic inflammatory disease beyond acute manifestations...
July 19, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28749818/fatal-septic-shock-triggered-by-donor-transmitted-varicella-zoster-virus-reinfection-3-days-after-lung-transplantation
#20
Samuel Lehingue, Romain Rambaud, Christophe Guervilly, Mélanie Adda, Jeanmarie Forel, Nadim Cassir, Christine Zandotti, Sami Hraiech, Laurent Papazian
No abstract text is available yet for this article.
July 27, 2017: Transplantation
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