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https://www.readbyqxmd.com/read/28990110/effects-of-butylphthalide-on-cognitive-decline-in-diabetic-rats
#1
Zhiyan Tian, Jinhua Wang, Yan Wang, Miao Zhang, Yuying Zhou
Butylphthalide, a component extracted from seeds of Chinese celery, is an effective neuroprotective agent used for the treatment of ischemic stroke and dementia. Diabetes may cause central nervous system damage, and diabetes is closely associated with dementia. The aim of the present study was to investigate the effects of butylphthalide on cognitive impairment in a streptozotocin‑induced diabetic rat model, and the underlying mechanisms of action. A total of 30 healthy male Sprague Dawley rats were randomly divided into the following 2 groups: Normal control (NC; n=10) and diabetes model (DM) groups (n=20)...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28926441/paine-s-celery-compound-celery-seed-bracer-or-cocaine-elixir
#2
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Anesthesiology
https://www.readbyqxmd.com/read/28798681/dl-3-n-butylphthalide-treatment-enhances-hemodynamics-and-ameliorates-memory-deficits-in-rats-with-chronic-cerebral-hypoperfusion
#3
Zhilin Xiong, Weibiao Lu, Lihui Zhu, Ling Zeng, Changzheng Shi, Zhen Jing, Yonghui Xiang, Wenxian Li, Chi Kwan Tsang, Yiwen Ruan, Li'an Huang
Our previous study has revealed that chronic cerebral hypoperfusion (CCH) activates a compensatory vascular mechanism attempting to maintain an optimal cerebral blood flow (CBF). However, this compensation fails to prevent neuronal death and cognitive impairment because neurons die prior to the restoration of normal CBF. Therefore, pharmacological invention may be critical to enhance the CBF for reducing neurodegeneration and memory deficit. Dl-3-n-butylphthalide (NBP) is a compound isolated from the seeds of Chinese celery and has been proven to be able to prevent neuronal loss, reduce inflammation and ameliorate memory deficits in acute ischemic animal models and stroke patients...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28747872/l-3-n-butylphthalide-protects-hspb8-k141n-mutation-induced-oxidative-stress-by-modulating-the-mitochondrial-apoptotic-and-nrf2-pathways
#4
Xiao-Dong Yang, Zhi-Dong Cen, Hai-Peng Cheng, Kai Shi, Jie Bai, Fei Xie, Hong-Wei Wu, Bei-Bei Li, Wei Luo
Charcot-Marie-Tooth disease (CMT), also known as hereditary motor and sensory neuropathy, is the most common inherited peripheral nerve disorder. Missense mutations, such as K141N, in the small heat shock protein HSPB8 are known to cause distal hereditary motor neuropathy 2A (dHMN2A) or Charcot-Marie-Tooth neuropathy type 2L (CMT2L). However, of critical clinical significance, very few specific therapies for this disease exist. In the present study, we investigated the impact of mutant K141N HSPB8 on mitochondrial distribution and function in a cellular model of CMT2L...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28701046/a-review-of-the-antioxidant-activity-of-celery-apium-graveolens-l
#5
Wesam Kooti, Nahid Daraei
Plants are an important source of natural active products that are different, based on mechanism and biological properties. Celery ( Apium graveolens L) is a plant from the apiaceae family and phenolic and antioxidant compounds of this plant have been studied by several scientists. The aim of this study was to review systematically the antioxidant activity of celery. Required articles were searched from databases such as Science Direct, PubMed, Scopus, and Springer. Keywords used in this study were Apium graveolens L, celery, antioxidant, free radical, leaf, and seed...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28572957/effect-of-spices-formulations-on-the-physicochemical-and-sensory-properties-of-nnam-gon-a-cameroonian-dish-prepared-with-cucurbitaceae-seeds
#6
Josiane E Manejo Djiogue, Richard M Nguimbou, Leopold N Tatsadjieu, Yannick D Mang, Nicolas Y Njintang
Nnam gon, a cake made by steam cooking a mixture of Cucurbitaceae seeds paste and others ingredients specially spices, is a highly prized dish in Central African region. A preliminary investigation conducted as part of this study highlighted that formulations used in the processing of Nnam gon vary according to the spices used. This study was carried out to determine the best formulation for the preparation of this dish. For this purpose, Nnam gon samples were produced from four formulations which differ according to the number of spices used: F0 (no spices); F1 (0...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28212313/chemoprevention-of-rat-mammary-carcinogenesis-by-apiaceae-spices
#7
Farrukh Aqil, Jeyaprakash Jeyabalan, Radha Munagala, Srivani Ravoori, Manicka V Vadhanam, David J Schultz, Ramesh C Gupta
Scientific evidence suggests that many herbs and spices have medicinal properties that alleviate symptoms or prevent disease. In this study, we examined the chemopreventive effects of the Apiaceae spices, anise, caraway, and celery seeds against 17β-estrogen (E2)-mediated mammary tumorigenesis in an ACI (August-Copenhagen Irish) rat model. Female ACI rats were given either control diet (AIN 93M) or diet supplemented with 7.5% (w/w) of anise, caraway, or celery seed powder. Two weeks later, one half of the animals in each group received subcutaneous silastic implants of E2...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27640886/dl-3-n-butylphthalide-attenuation-of-methamphetamine-induced-neurotoxicity-in-sh-sy5y-neuroblastoma-cells
#8
Jun Zhao, Jianuo Liu, Enquan Xu, Yunlin Liu, Anmu Xie, Huangui Xiong
AIMS: Methamphetamine (Meth) abuse causes neural injury in the brain. There are no efficacious therapies available to treat Meth-induce neural injury. The present study intended to test the therapeutic potential of dl-3-n-butylphthalide (NBP), a chemical compound extracted originally from the seeds of Chinese Celery, in the amelioration and prevention of Meth-induced neural injury. MAIN METHODS: Experiments were carried out on SH-SY5Y cells. Neuronal injury and apoptotic cell death were detected by MTT assay and analysis of nuclear morphology...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27439966/l-3-n-butylphthalide-rescues-hippocampal-synaptic-failure-and-attenuates-neuropathology-in-aged-app-ps1-mouse-model-of-alzheimer-s-disease
#9
Yu Zhang, Long-Jian Huang, Si Shi, Shao-Feng Xu, Xiao-Liang Wang, Ying Peng
AIMS: Our previous studies showed that L-3-n-butylphthalide (L-NBP), an extract from seeds of Apium graveolens Linn (Chinese celery), improved cognitive ability in animal models of cerebral ischemia, vascular dementia, and Alzheimer's disease (AD). It is well known that cognitive deficit of AD is caused by synaptic dysfunction. In this study, we investigated the effect of L-NBP on hippocampal synaptic function in APP/PS1 AD transgenic mice and related mechanisms. METHODS: Eighteen-month-old APP/PS1 transgenic (Tg) mice were administrated 15 mg/kg L-NBP by oral gavage for 3 months...
December 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27041871/review-of-scientific-evidence-of-medicinal-convoy-plants-in-traditional-persian-medicine
#10
REVIEW
Seyede Nargess Sadati, Mohammad Reza Shams Ardekani, Nastaran Ebadi, Maryam Yakhchali, Azadeh Raees Dana, Fatemeh Masoomi, Mahnaz Khanavi, Farid Ramezany
One concept used in traditional Persian medicine (TPM) for multidrug therapy is that of the convoy drug (Mobadregh). According to TPM texts, convoy drugs are substances (or drugs), which facilitate the access of drugs or foods to the whole body or to specific organs. This study reviewed some convoy drugs presented in TPM, their biological effects, and their probable interactions with main drugs, considering the increased absorption through inhibition of P-glycoprotein (P-gp) efflux function, bioavailability-enhancing effects, and decreased metabolism of the main drug using electronic databases including PubMed, Scopus, ScienceDirect, and Google Scholar in November and December, 2013...
January 2016: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/26968782/dl-3-n-butylphthalide-suppresses-pdgf-bb-stimulated-vascular-smooth-muscle-cells-proliferation-via-induction-of-autophagy
#11
Haijuan Hu, Bin Liu, Yabei Zuo, Demin Liu, Ruiqin Xie, Wei Cui
AIMS: Vascular smooth muscle cells (VSMCs) played an important role in vascular remodeling. dl-3-n-butylphthalide (NBP) was extracted as a pure component from seeds of Apium graveolens Linn (Chinese celery) for protecting neurons activity, but the role of NBP on VSMCs was not clearly clarified. MAIN METHODS: Cell proliferation was measured by MTS and flow cytometry. Western blot analysis and transmission electron microscopy were performed to analyze the relative protein expression and autophagosome...
April 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26940333/protective-and-hypoglycemic-effects-of-celery-seed-on-streptozotocin-induced-diabetic-rats-experimental-and-histopathological-evaluation
#12
Faezeh Tashakori-Sabzevar, Masoud Ramezani, Hossein Hosseinzadeh, Seyyed Mohammad Reza Parizadeh, Ahmad Reza Movassaghi, Ahmad Ghorbani, Seyed Ahmad Mohajeri
AIMS: Diabetes mellitus is a major manifestation of metabolic disorder which presents with hyperglycemia (high levels of serum blood sugar). In the present study, we aimed to investigate the effects of celery seed extract on different biochemical factors and histopathological changes in normal and streptozotocin (STZ)-induced diabetic rats. METHODS: A total of 35 male Wistar rats were divided into five groups (one normal and four diabetic groups). STZ was injected intraperitoneally to induce diabetes...
August 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/26633337/accurate-mass-gc-lc-quadrupole-time-of-flight-mass-spectrometry-analysis-of-fatty-acids-and-triacylglycerols-of-spicy-fruits-from-the-apiaceae-family
#13
Thao Nguyen, Mario Aparicio, Mahmoud A Saleh
The triacylglycerol (TAG) structure and the regio-stereospecific distribution of fatty acids (FA) of seed oils from most of the Apiaceae family are not well documented. The TAG structure ultimately determines the final physical properties of the oils and the position of FAs in the TAG molecule affects the digestion; absorption and metabolism; and physical and technological properties of TAGs. Fixed oils from the fruits of dill (Anethum graveolens), caraway (Carum carvi), cumin (Cuminum cyminum), coriander (Coriandrum sativum), anise (Pimpinella anisum), carrot (Daucus carota), celery (Apium graveolens), fennel (Foeniculum vulgare), and Khella (Ammi visnaga), all from the Apiaceae family, were extracted at room temperature in chloroform/methanol (2:1 v/v) using percolators...
December 2, 2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26462366/celery-seed-and-related-extracts-with-antiarthritic-antiulcer-and-antimicrobial-activities
#14
REVIEW
Michael C Powanda, Michael W Whitehouse, K D Rainsford
Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis...
2015: Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques
https://www.readbyqxmd.com/read/26327560/a-food-derived-flavonoid-luteolin-protects-against-angiotensin-ii-induced-cardiac-remodeling
#15
Atsuko Nakayama, Hiroyuki Morita, Tomoko Nakao, Toshihiro Yamaguchi, Tomokazu Sumida, Yuichi Ikeda, Hidetoshi Kumagai, Yoshihiro Motozawa, Tsukasa Takahashi, Atsushi Imaizumi, Tadashi Hashimoto, Ryozo Nagai, Issei Komuro
Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many herbal extracts including celery, green pepper, perilla leaves and seeds, and chamomile, is a known to be a potent antioxidant and was previously demonstrated to exert an antifibrotic effect in the lungs and the liver...
2015: PloS One
https://www.readbyqxmd.com/read/25916469/celery-seed-extract-blocks-peroxide-injury-in-macrophages-via-notch1-nf-%C3%AE%C2%BAb-pathway
#16
Yanhong Si, Shoudong Guo, Yongqi Fang, Shucun Qin, Furong Li, Ying Zhang, Peng Jiao, Chunduo Zhang, Linlin Gao
Oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and injury is one of the major atherogenic factors. This study is aimed to investigate the protective effect of celery seed extract (CSE) on ox-LDL-induced injury of macrophages and the underlying signaling pathway. RAW264.7 macrophages were pre-incubated with CSE for 24 h, followed by stimulation with ox-LDL. Oil red O staining and enzymatic colorimetry indicated CSE significantly lessened lipid droplets and total cholesterol (TC) content in ox-LDL-injured macrophages...
2015: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/25790672/-adjunctive-treatment-of-axial-undifferentiated-spondyloarthritis-by-qiangji-recipe-a-clinical-study
#17
RANDOMIZED CONTROLLED TRIAL
Meng-Yin He, Fu-Yuan Fan
OBJECTIVE: To evaluate the clinical efficacy and safety of Qiangji Recipe (QR) in ad- junctive treatment of axial undifferentiated spondyloarthritis (axuSpA) through a four-week open study. METHODS: Fifty-four axuSpA patients of Shen-deficiency Du-channel cold syndrome (SDDCS) in line with inclusive criteria were recruited and assigned to the treatment group and the control group according to random digit table, 27 in each group. Patients in the control group took Celecoxib Capsule (0...
January 2015: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/25352064/protective-effect-of-3-n-butylphthalide-against-hypertensive-nephropathy-in-spontaneously-hypertensive-rats
#18
Jun Zhu, Yantao Zhang, Changhai Yang
Previous studies have demonstrated that a natural product of celery seeds, 3‑n‑butylphthalide (NBP), has significant antihypertensive effects that are widely utilized in Chinese traditional medicine. The present study aimed to investigate the effects of NBP on hypertensive nephropathy, as well as the mechanisms underlying this disease in spontaneously hypertensive rats (SHRs). SHRs were treated orally with saline, NBP (15 or 30 mg/kg) or losartan (10 mg/kg) daily for 20 weeks, during which time blood pressure was measured every four weeks...
February 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25279371/larvicidal-repellent-and-irritant-potential-of-the-seed-derived-essential-oil-of-apium-graveolens-against-dengue-vector-aedes-aegypti-l-diptera-culicidae
#19
Sarita Kumar, Monika Mishra, Naim Wahab, Radhika Warikoo
Aedes aegypti L. is one of the primary disease vectors spreading various dreadful diseases throughout the world, specifically over tropics and subtropics. Keeping in view the adverse effects of chemical insecticides-based intervention measures, the eco-friendly and bio-degradable essential oil extracted from the seeds of celery, Apium graveolens were investigated for its efficacy against Ae. aegypti. Larvicidal bioassay carried out with the seed oil against early fourth instars of Ae. aegypti caused an LC50 and LC90 values of 16...
2014: Frontiers in Public Health
https://www.readbyqxmd.com/read/25270867/computer-aided-method-for-identification-of-major-flavone-flavonol-glycosides-by-high-performance-liquid-chromatography-diode-array-detection-tandem-mass-spectrometry-hplc-dad-ms-ms
#20
Zhengfang Wang, Longze Lin, James M Harnly, Peter de B Harrington, Pei Chen
A new computational tool is proposed here for tentatively identifying major (UV quantifiable) flavone/flavonol glycoside peaks of high performance liquid chromatogram (HPLC)-diode array detection (DAD)-tandem mass spectrometry (MS/MS) profiles based on a MATLAB-based script implementing an in-house algorithm. The HPLC-DAD-MS/MS profiles of red onion, Chinese lettuce, carrot leaf, and celery seed extracts were analyzed by the proposed computer-aided screening method for identifying possible flavone/flavonol glycoside peaks from the HPLC-UV and MS total ion current (TIC) chromatograms...
November 2014: Analytical and Bioanalytical Chemistry
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