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celery seed

Jun Zhao, Jianuo Liu, Enquan Xu, Yunlin Liu, Anmu Xie, Huangui Xiong
AIMS: Methamphetamine (Meth) abuse causes neural injury in the brain. There are no efficacious therapies available to treat Meth-induce neural injury. The present study intended to test the therapeutic potential of DL-3-n-Butylphthalide (NBP), a chemical compound extracted originally from the seeds of Chinese Celery, in the amelioration and prevention of Meth-induced neural injury. MAIN METHODS: Experiments were carried out on SH-SY5Y cells. Neuronal injury and apoptotic cell death were detected by MTT assay and analysis of nuclear morphology...
September 15, 2016: Life Sciences
Yu Zhang, Long-Jian Huang, Si Shi, Shao-Feng Xu, Xiao-Liang Wang, Ying Peng
AIMS: Our previous studies showed that L-3-n-butylphthalide (L-NBP), an extract from seeds of Apium graveolens Linn (Chinese celery), improved cognitive ability in animal models of cerebral ischemia, vascular dementia, and Alzheimer's disease (AD). It is well known that cognitive deficit of AD is caused by synaptic dysfunction. In this study, we investigated the effect of L-NBP on hippocampal synaptic function in APP/PS1 AD transgenic mice and related mechanisms. METHODS: Eighteen-month-old APP/PS1 transgenic (Tg) mice were administrated 15 mg/kg L-NBP by oral gavage for 3 months...
July 20, 2016: CNS Neuroscience & Therapeutics
Seyede Nargess Sadati, Mohammad Reza Shams Ardekani, Nastaran Ebadi, Maryam Yakhchali, Azadeh Raees Dana, Fatemeh Masoomi, Mahnaz Khanavi, Farid Ramezany
One concept used in traditional Persian medicine (TPM) for multidrug therapy is that of the convoy drug (Mobadregh). According to TPM texts, convoy drugs are substances (or drugs), which facilitate the access of drugs or foods to the whole body or to specific organs. This study reviewed some convoy drugs presented in TPM, their biological effects, and their probable interactions with main drugs, considering the increased absorption through inhibition of P-glycoprotein (P-gp) efflux function, bioavailability-enhancing effects, and decreased metabolism of the main drug using electronic databases including PubMed, Scopus, ScienceDirect, and Google Scholar in November and December, 2013...
January 2016: Pharmacognosy Reviews
Haijuan Hu, Bin Liu, Yabei Zuo, Demin Liu, Ruiqin Xie, Wei Cui
AIMS: Vascular smooth muscle cells (VSMCs) played an important role in vascular remodeling. dl-3-n-butylphthalide (NBP) was extracted as a pure component from seeds of Apium graveolens Linn (Chinese celery) for protecting neurons activity, but the role of NBP on VSMCs was not clearly clarified. MAIN METHODS: Cell proliferation was measured by MTS and flow cytometry. Western blot analysis and transmission electron microscopy were performed to analyze the relative protein expression and autophagosome...
April 15, 2016: Life Sciences
Faezeh Tashakori-Sabzevar, Masoud Ramezani, Hossein Hosseinzadeh, Seyyed Mohammad Reza Parizadeh, Ahmad Reza Movassaghi, Ahmad Ghorbani, Seyed Ahmad Mohajeri
AIMS: Diabetes mellitus is a major manifestation of metabolic disorder which presents with hyperglycemia (high levels of serum blood sugar). In the present study, we aimed to investigate the effects of celery seed extract on different biochemical factors and histopathological changes in normal and streptozotocin (STZ)-induced diabetic rats. METHODS: A total of 35 male Wistar rats were divided into five groups (one normal and four diabetic groups). STZ was injected intraperitoneally to induce diabetes...
August 2016: Acta Diabetologica
Thao Nguyen, Mario Aparicio, Mahmoud A Saleh
The triacylglycerol (TAG) structure and the regio-stereospecific distribution of fatty acids (FA) of seed oils from most of the Apiaceae family are not well documented. The TAG structure ultimately determines the final physical properties of the oils and the position of FAs in the TAG molecule affects the digestion; absorption and metabolism; and physical and technological properties of TAGs. Fixed oils from the fruits of dill (Anethum graveolens), caraway (Carum carvi), cumin (Cuminum cyminum), coriander (Coriandrum sativum), anise (Pimpinella anisum), carrot (Daucus carota), celery (Apium graveolens), fennel (Foeniculum vulgare), and Khella (Ammi visnaga), all from the Apiaceae family, were extracted at room temperature in chloroform/methanol (2:1 v/v) using percolators...
December 2, 2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Michael C Powanda, Michael W Whitehouse, K D Rainsford
Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis...
2015: Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques
Atsuko Nakayama, Hiroyuki Morita, Tomoko Nakao, Toshihiro Yamaguchi, Tomokazu Sumida, Yuichi Ikeda, Hidetoshi Kumagai, Yoshihiro Motozawa, Tsukasa Takahashi, Atsushi Imaizumi, Tadashi Hashimoto, Ryozo Nagai, Issei Komuro
Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many herbal extracts including celery, green pepper, perilla leaves and seeds, and chamomile, is a known to be a potent antioxidant and was previously demonstrated to exert an antifibrotic effect in the lungs and the liver...
2015: PloS One
Yanhong Si, Shoudong Guo, Yongqi Fang, Shucun Qin, Furong Li, Ying Zhang, Peng Jiao, Chunduo Zhang, Linlin Gao
Oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and injury is one of the major atherogenic factors. This study is aimed to investigate the protective effect of celery seed extract (CSE) on ox-LDL-induced injury of macrophages and the underlying signaling pathway. RAW264.7 macrophages were pre-incubated with CSE for 24 h, followed by stimulation with ox-LDL. Oil red O staining and enzymatic colorimetry indicated CSE significantly lessened lipid droplets and total cholesterol (TC) content in ox-LDL-injured macrophages...
2015: American Journal of Chinese Medicine
Meng-Yin He, Fu-Yuan Fan
OBJECTIVE: To evaluate the clinical efficacy and safety of Qiangji Recipe (QR) in ad- junctive treatment of axial undifferentiated spondyloarthritis (axuSpA) through a four-week open study. METHODS: Fifty-four axuSpA patients of Shen-deficiency Du-channel cold syndrome (SDDCS) in line with inclusive criteria were recruited and assigned to the treatment group and the control group according to random digit table, 27 in each group. Patients in the control group took Celecoxib Capsule (0...
January 2015: Chinese Journal of Integrated Traditional and Western Medicine
Jun Zhu, Yantao Zhang, Changhai Yang
Previous studies have demonstrated that a natural product of celery seeds, 3‑n‑butylphthalide (NBP), has significant antihypertensive effects that are widely utilized in Chinese traditional medicine. The present study aimed to investigate the effects of NBP on hypertensive nephropathy, as well as the mechanisms underlying this disease in spontaneously hypertensive rats (SHRs). SHRs were treated orally with saline, NBP (15 or 30 mg/kg) or losartan (10 mg/kg) daily for 20 weeks, during which time blood pressure was measured every four weeks...
February 2015: Molecular Medicine Reports
Sarita Kumar, Monika Mishra, Naim Wahab, Radhika Warikoo
Aedes aegypti L. is one of the primary disease vectors spreading various dreadful diseases throughout the world, specifically over tropics and subtropics. Keeping in view the adverse effects of chemical insecticides-based intervention measures, the eco-friendly and bio-degradable essential oil extracted from the seeds of celery, Apium graveolens were investigated for its efficacy against Ae. aegypti. Larvicidal bioassay carried out with the seed oil against early fourth instars of Ae. aegypti caused an LC50 and LC90 values of 16...
2014: Frontiers in Public Health
Zhengfang Wang, Longze Lin, James M Harnly, Peter de B Harrington, Pei Chen
A new computational tool is proposed here for tentatively identifying major (UV quantifiable) flavone/flavonol glycoside peaks of high performance liquid chromatogram (HPLC)-diode array detection (DAD)-tandem mass spectrometry (MS/MS) profiles based on a MATLAB-based script implementing an in-house algorithm. The HPLC-DAD-MS/MS profiles of red onion, Chinese lettuce, carrot leaf, and celery seed extracts were analyzed by the proposed computer-aided screening method for identifying possible flavone/flavonol glycoside peaks from the HPLC-UV and MS total ion current (TIC) chromatograms...
November 2014: Analytical and Bioanalytical Chemistry
Yaping Huai, Yanhong Dong, Jing Xu, Nan Meng, Chunfeng Song, Wenbin Li, Peiyuan Lv
As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute ischemic stroke. The activated Akt kinase pathway can prevent the death of nerve cells and exhibit neuroprotective effects in the brain after stroke. This study provides the hypothesis that l-3-n-butylphthalide has a certain therapeutic effect on vascular dementia, and its mechanism depends on the activation of the Akt kinase pathway...
July 5, 2013: Neural Regeneration Research
Zhengfang Wang, Mengliang Zhang, Peter de B Harrington
Three novel two-way baseline correction algorithms, that is, orthogonal basis (OB), fuzzy optimal associative memory (FOAM), and polynomial fitting (PF), were evaluated with high performance liquid chromatography-mass spectrometry (HPLC-MS) and gas chromatography/mass spectrometry (GC/MS) data objects. Among these algorithms, both OB and FOAM are two-way baseline correction algorithms, which reconstruct the entire two-way backgrounds from blank data objects, while the PF algorithm is a pseudo-two-way method, which models each ion chromatogram baseline with a third-order polynomial...
September 16, 2014: Analytical Chemistry
Jie Li, Songyun Zhang, Lihui Zhang, Ruiying Wang, Mian Wang
Diabetes mellitus is associated with rapid cognitive decline. Currently, there is no effective treatment for cognitive dysfunction induced by diabetes. L-3-n-Butylphthalide (L-NBP) is a nerve protective drug extracted from seeds of celery, which has been proved to improve learning and memory in vascular dementia animal models by improving microcirculation, protecting mitochondria and increasing long-term potentiation (LTP). NR2B, one of the subunits of N-methyl-D-aspartate receptor, has been proved to be an important factor for the formation of LTP...
January 2015: Cell Biochemistry and Biophysics
Jing Xiang, Jie Pan, Fujun Chen, Linlin Zheng, Yue Chen, Shutao Zhang, Wanyu Feng
L-3-n-butylphthalide (L-NBP), an extract from seeds of Apium graveolens Linn (Chinese celery), has been shown to have neuroprotective effects on cerebral ischemic, vascular dementia and amyloid-beta (Abeta)-induced animal models by inhibiting oxidative injury, neuronal apoptosis and glial activation, regulating amyloid-beta protein precursor (AbetaPP) processing and reducing Abeta generation. The objective of this study was to investigate the effects of L-3-n-butylphthalide on memory impairment and the expression of brain neurotrophic derived factor (BNDF), kinaseB (TrkB), phosphatidylinositol 3 kinase (PI3K) and Akt in APP/PS1 double transgenic mouse models...
2014: International Journal of Clinical and Experimental Medicine
Akira Morisaki, Naohiro Yamada, Shiori Yamanaka, Kenji Matsui
Among the soybean germplasm in Japan, two varieties, Nishiyamahitashi 98-5 (NH) and Shinanokurakake (SKK), have an intense seaweed-like flavor after cooking. Gas-liquid chromatography with mass spectrometry (GC-MS) indicated that a significant amount (11.5 ± 3.46 μg g(-1) for NH and 6.66 ± 0.91 μg g(-1) for SKK) of dimethyl sulfide (DMS) was formed after heat treatment. DMS is formed from S-methylmethionine (SMM, vitamin U). SMM was detected in all soybean varieties examined here, but its concentration in NH and SKK seeds was >100-fold higher than in the other varieties and ranged from 75 to 290 μg g(-1)...
August 20, 2014: Journal of Agricultural and Food Chemistry
Mandana Tavakkoli-Kakhki, Malihe Motavasselian, Mahmoud Mosaddegh, Mohammad Mahdi Esfahani, Mohammad Kamalinejad, Mohsen Nematy, Saeid Eslami
OBJECTIVES: Considering the increasing prevalence of depression in modern societies and the positive effects of omega-3 polyunsaturated fatty acids on depression, this study aims to investigate the omega-3 and omega-6 content of various foodstuffs, prescribed or prohibited by Iranian Traditional Medicine (ITM). MATERIALS AND METHODS: Firstly, reliable sources of Iranian Traditional Medicine were reviewed in order to identify the prescribed and prohibited foodstuffs for depressed patients...
July 2014: Avicenna Journal of Phytomedicine
San Nguyen, Huang Huang, Brian C Foster, Teresa W Tam, Tim Xing, Myron L Smith, John T Arnason, Humayoun Akhtar
PURPOSE: To study the effect of functional foods on human cytochrome P450 (CYP) and the gut bacterial microflora that may potentially affect drug metabolism and ultimately affect human health and wellness. METHODS: This study examined a variety of food plants from the Apiaceae, Fabaceae, and Lamiaceae families for their inhibitory potential on cytochrome 2D6-, 3A4-, 3A5-, and 3A7-mediated metabolism. The antimicrobial effects of these samples were also investigated with 7 selected bacterial surrogate species to determine potential effects on the gut microflora...
2014: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
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